LiteFold/InterPro · Datasets at Hugging Face

IPR010331

10,331

Exopolysaccharide synthesis, ExoD

ExoD

Family

4,470

false

Among the bacterial genes required for nodule invasion are the exo genes. These genes are involved in the production of an extracellular polysaccharide. Mutations in the exoD result in altered exopolysaccharide production and defects in nodule invasion [ ].

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06055", "PIRSF033239", "PTHR41795" ]

[ "ExoD", "ExoD", "" ]

[ 4470, 4119, 4403 ]

3

[]

0

[]

0

[ "PUB00012240" ]

[ "1987158" ]

[ "The exoD gene of Rhizobium meliloti encodes a novel function needed for alfalfa nodule invasion." ]

[ 1991 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriaceae", "unclassified sequences" ]

[ 4387, 21, 10, 52 ]

4

[]

0

true

Family

Exopolysaccharide synthesis, ExoD

ExoD

4

IPR010332

10,332

Terminase, ATPase subunit, N-terminal domain

ATPase_terminase-su_N

Domain

4,881

false

This entry represents the N-terminal domain of Terminase, ATPase subunit from Escherichia phage P2 and similar proteins from tailed bacteriophages and bacterial prophages. Terminases are viral proteins that are involved in packaging viral DNA into the capsid [ ].

[]

0

[ "PFAM" ]

[ "PF06056" ]

[ "Terminase_5" ]

[ 4881 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00012241" ]

[ "10949585" ]

[ "The terminase enzyme from bacteriophage lambda: a DNA-packaging machine." ]

[ 2000 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 34, 4587, 23, 197, 40 ]

5

[]

0

true

Domain

Terminase, ATPase subunit, N-terminal domain

ATPase_terminase-su_N

8

IPR010333

10,333

Bacterial virulence

VirJ

Domain

2,743

false

This entry contains several bacterial VirJ virulence proteins. VirJ is thought to be involved in the type IV secretion system. It is thought that the substrate proteins localised to the periplasm may associate with the pilus in a manner that is mediated by VirJ, and suggest a two-step process for type IV secretion in A...

[]

0

[ "PFAM" ]

[ "PF06057" ]

[ "VirJ" ]

[ 2743 ]

1

[]

0

[]

0

[ "PUB00012242" ]

[ "12207700" ]

[ "Agrobacterium type IV secretion is a two-step process in which export substrates associate with the virulence protein VirJ in the periplasm." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halobellus clavatus", "Plasmid Ti", "ecological metagenomes" ]

[ 2723, 7, 1, 1, 11 ]

5

[]

0

true

Domain

Bacterial virulence

VirJ

6

IPR010334

10,334

mRNA-decapping enzyme subunit 1

Dcp1

Family

6,700

false

An essential step in mRNA turnover is decapping. In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2. Dcp1 is a coactivator that binds to the decapping enzyme Dcp2 and forms a decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their deg...

[ "GO:0008047", "GO:0000290", "GO:0043085" ]

[ "enzyme activator activity", "deadenylation-dependent decapping of nuclear-transcribed mRNA", "positive regulation of catalytic activity" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06058", "PTHR16290" ]

[ "DCP1", "" ]

[ 6405, 6486 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-430039", "R-CEL-450385", "R-CEL-450513", "R-HSA-430039", "R-HSA-450385", "R-HSA-450513", "R-HSA-975957", "R-MMU-430039", "R-MMU-450385", "R-MMU-450513", "R-MMU-975957", "R-SCE-430039", "R-SCE-450385", "R-SCE-450513" ]

[ "REACTOME:R-CEL-430039", "REACTOME:R-CEL-450385", "REACTOME:R-CEL-450513", "REACTOME:R-HSA-430039", "REACTOME:R-HSA-450385", "REACTOME:R-HSA-450513", "REACTOME:R-HSA-975957", "REACTOME:R-MMU-430039", "REACTOME:R-MMU-450385", "REACTOME:R-MMU-450513", "REACTOME:R-MMU-975957", "REACTOME:R-SCE-430...

14

[ "1q67", "2lyd", "2qkl", "2qkm", "4b6h", "5j3q", "5j3t", "5j3y", "5jp4", "5kq1", "5kq4", "5lon", "5lop", "5n2v", "6am0", "6y3z" ]

16

[ "PUB00033653", "PUB00076141", "PUB00096644" ]

[ "16341225", "24510189", "32366357" ]

[ "Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe.", "The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.", "mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls devel...

[ 2006, 2014, 2020 ]

3

[]

0

null

[ "Eukaryota" ]

[ 6700 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 8, 2, 11, 6, 1, 15, 6, 1, 1, 38 ]

12

true

Family

mRNA-decapping enzyme subunit 1

Dcp1

8

IPR010335

10,335

Mesothelin

Family

2,296

false

This family consists of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, which participates in cell adhesion, tumour progression, ...

[]

0

[ "PFAM" ]

[ "PF06060" ]

[ "Mesothelin" ]

[ 2296 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-163125", "R-HSA-381426", "R-HSA-8957275", "R-MMU-163125", "R-MMU-381426", "R-MMU-8957275", "R-RNO-163125", "R-RNO-381426", "R-RNO-8957275" ]

[ "REACTOME:R-HSA-163125", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-163125", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8957275", "REACTOME:R-RNO-163125", "REACTOME:R-RNO-381426", "REACTOME:R-RNO-8957275" ]

9

[ "4f3f", "7u9j", "7ued", "8cx3", "8cxc", "8cyh", "8cz8", "8fsl", "8vm1" ]

9

[ "PUB00013403", "PUB00013404", "PUB00061605", "PUB00101012", "PUB00101013" ]

[ "10733593", "10500211", "19128473", "32983962", "33938941" ]

[ "Mesothelin is not required for normal mouse development or reproduction.", "Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma.", "Mesothelin, Stereocilin, and Otoancorin are predicted to have superhelical structures with ARM...

[ 2000, 1999, 2009, 2020, 2021 ]

5

[ "IPR026664" ]

[]

1

0

1

[ "Eumetazoa" ]

[ 2296 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 9, 4, 6 ]

4

true

Family

Mesothelin

6

IPR010339

10,339

TIP49, P-loop domain

TIP49_P-loop

Domain

10,422

false

This entry represents the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the AAA ATPase, central region domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hea...

[ "GO:0005524" ]

[ "ATP binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06068" ]

[ "TIP49" ]

[ 10422 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.4.12", "R-CEL-5689880", "R-DME-201722", "R-DME-5689603", "R-DME-5689880", "R-DME-5696394", "R-DRE-201722", "R-DRE-5689880", "R-HSA-171319", "R-HSA-201722", "R-HSA-3214847", "R-HSA-5689603", "R-HSA-5689880", "R-HSA-5696394", "R-HSA-606279", "R-MMU-201722", "R-MMU-5689603", "R-M...

[ "EC:3.6.4.12", "REACTOME:R-CEL-5689880", "REACTOME:R-DME-201722", "REACTOME:R-DME-5689603", "REACTOME:R-DME-5689880", "REACTOME:R-DME-5696394", "REACTOME:R-DRE-201722", "REACTOME:R-DRE-5689880", "REACTOME:R-HSA-171319", "REACTOME:R-HSA-201722", "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-5689603...

26

[ "2c9o", "2cqa", "2xsz", "3uk6", "4wvy", "4ww4", "5fm6", "5fm7", "5oaf", "5oun", "6fhs", "6fml", "6fo1", "6gej", "6gen", "6h7x", "6hts", "6igm", "6k0r", "6qi8", "6qi9", "7aho", "7ole", "7p6x", "7zi4", "8av6", "8ets", "8etu", "8etw", "8eu9", "8euf", "8oo7"...

71

[ "PUB00012248", "PUB00012249" ]

[ "12464178", "10902922" ]

[ "Reptin and pontin antagonistically regulate heart growth in zebrafish embryos.", "Chromosome mapping and expression of human tip49 family genes." ]

[ 2002, 2000 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "marine sediment metagenome", "uncultured Caudovirales phage" ]

[ 208, 8, 10202, 3, 1 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 2, 3, 3, 14, 11, 2, 12, 9, 2, 2, 21 ]

12

true

Domain

TIP49, P-loop domain

TIP49_P-loop

7

IPR010340

10,340

Herpesvirus UL11/UL32

Herpes_UL11/UL32

Family

217

false

The large phosphorylated protein (UL32-like) of herpes viruses is the polypeptide most frequently reactive in immuno-blotting analyses with antisera when compared with other viral proteins [ ].

[ "GO:0005198" ]

[ "structural molecule activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06070" ]

[ "Herpes_UL32" ]

[ 217 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "5vku", "6nhj", "6q1f", "7et3", "7etj", "7eto", "7liv", "7lj3", "8tep", "8tes", "8tet", "8teu", "8tew" ]

13

[ "PUB00012251" ]

[ "2455019" ]

[ "Prokaryotic expression of immunogenic polypeptides of the large phosphoprotein (pp150) of human cytomegalovirus." ]

[ 1988 ]

1

[]

0

null

[ "Herpesvirales", "Homo sapiens" ]

[ 216, 1 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus UL11/UL32

Herpes_UL11/UL32

9

IPR010341

10,341

Protein CORTICAL MICROTUBULE DISORDERING

CORD

Family

3,801

false

This entry (ex DUF936) represents Protein CORTICAL MICROTUBULE DISORDERING (CORD) proteins found in plants. CORD proteins are microtubule-associated proteins that are required, redundantly with CORD2, for the formation of the pitted secondary cell wall of metaxylem vessels [ ]. CORD1 from Arabidopsis thaliana controls ...

[]

0

[ "PANTHER" ]

[ "PTHR31928" ]

[ "" ]

[ 3801 ]

1

[]

0

[]

0

[ "PUB00163241", "PUB00163242" ]

[ "2913346", "29133465" ]

[ "The management of chronic interstitial cystitis by substitution cystoplasty.", "CORTICAL MICROTUBULE DISORDERING1 Is Required for Secondary Cell Wall Patterning in Xylem Vessels." ]

[ 1989, 2017 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3801 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 37, 25, 47 ]

3

true

Family

Protein CORTICAL MICROTUBULE DISORDERING

CORD

1

IPR010342

10,342

Protein of unknown function DUF938

DUF938

Family

5,761

false

This family consists of several hypothetical proteins from both prokaryotes and eukaryotes. Chordate members are known as 'methyltransferase-like 26'. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06080", "PTHR20974" ]

[ "DUF938", "" ]

[ 5759, 5698 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3555, 2143, 63 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 2, 8, 4, 6 ]

6

true

Family

Protein of unknown function DUF938

DUF938

5

IPR010343

10,343

Aromatic acid exporter family member 1

ArAE_1

Family

8,374

false

This family consists of bacterial proteins with three transmembrane regions that are purported to be aromatic acid exporters.

[]

0

[ "PFAM" ]

[ "PF06081" ]

[ "ArAE_1" ]

[ 8374 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 8329, 4, 41 ]

3

[]

0

true

Family

Aromatic acid exporter family member 1

ArAE_1

2

IPR010345

10,345

Interleukin-17 family

IL-17_fam

Family

5,849

false

Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-17 (IL-17) is a potent proinflammatory cytokine produced by activated memory T cells [ ]. The I...

[ "GO:0005125", "GO:0005576" ]

[ "cytokine activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF06083" ]

[ "IL17" ]

[ 5849 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-448424", "R-HSA-6785807", "R-HSA-9705671" ]

[ "REACTOME:R-HSA-448424", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-9705671" ]

3

[ "1jpy", "2vxs", "3jvf", "4hr9", "4hsa", "4qhu", "5hhv", "5hhx", "5hi3", "5hi4", "5hi5", "5n7w", "5n92", "5nan", "5vb9", "6hg4", "6hg9", "6hgo", "6ppg", "6wio", "6wir", "7ama", "7amg", "7uwj", "7uwk", "7uwl", "7uwm", "7uwn", "7wkx", "7z2m", "7zan", "8b7w"...

51

[ "PUB00012254", "PUB00046068", "PUB00090974" ]

[ "11781375", "15485625", "28099418" ]

[ "IL-17: prototype member of an emerging cytokine family.", "Interleukin-17 family members and inflammation.", "IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses." ]

[ 2002, 2004, 2017 ]

3

[]

[ "IPR020440" ]

0

1

0

[ "Metazoa", "Saimiriine herpesvirus 2" ]

[ 5846, 3 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 8, 10, 13, 17 ]

5

true

Family

Interleukin-17 family

IL-17_fam

6

IPR010347

10,347

Tyrosyl-DNA phosphodiesterase I

Tdp1

Family

7,360

false

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate [ , ].

[ "GO:0008081", "GO:0006281", "GO:0005634" ]

[ "phosphoric diester hydrolase activity", "DNA repair", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06087", "PTHR12415" ]

[ "Tyr-DNA_phospho", "" ]

[ 7304, 7097 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.4.-", "PWY-5978", "PWY-6129", "PWY-6689", "PWY-7119", "PWY-7366", "R-HSA-5693571", "R-MMU-5693571", "R-RNO-5693571" ]

[ "EC:3.1.4.-", "METACYC:PWY-5978", "METACYC:PWY-6129", "METACYC:PWY-6689", "METACYC:PWY-7119", "METACYC:PWY-7366", "REACTOME:R-HSA-5693571", "REACTOME:R-MMU-5693571", "REACTOME:R-RNO-5693571" ]

9

[ "1jy1", "1mu7", "1mu9", "1nop", "1q32", "1qzq", "1rff", "1rfi", "1rg1", "1rg2", "1rgt", "1rgu", "1rh0", "3sq3", "3sq5", "3sq7", "3sq8", "5nw9", "5nwa", "6dhu", "6die", "6dih", "6dim", "6djd", "6dje", "6djf", "6djg", "6djh", "6dji", "6djj", "6mj5", "6myz"...

53

[ "PUB00069456", "PUB00069457", "PUB00069458" ]

[ "12023295", "19505854", "16141202" ]

[ "Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1.", "Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.", "Human Tdp1 cleaves a broad spectrum of substrates, inc...

[ 2002, 2009, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota" ]

[ 10, 7348, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 2, 1, 1, 12, 3, 2, 6, 8, 1, 1, 15 ]

12

true

Family

Tyrosyl-DNA phosphodiesterase I

Tdp1

2

IPR010349

10,349

L-asparaginase II

Asparaginase_II

Family

7,984

false

This family consists of several bacterial L-asparaginase II proteins. L-asparaginase ( ) catalyses the hydrolysis of L-asparagine to L-aspartate and ammonium. Rhizobium etli possesses two asparaginases: asparaginase I, which is thermostable and constitutive, and asparaginase II, which is thermolabile, induced by aspara...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06089", "PTHR42110" ]

[ "Asparaginase_II", "" ]

[ 7983, 7937 ]

2

[]

0

[ "7os3", "7os5", "7os6", "7ou1", "7oz6", "8cly", "8clz", "8col", "8ori", "8osw", "8rua", "8rud", "8rue", "8ruf", "8rug", "9g66", "9g67", "9g68", "9qct", "9qcu", "9qcw", "9qcy", "9qcz" ]

23

[ "PUB00012260" ]

[ "10930734" ]

[ "The L-asparagine operon of Rhizobium etli contains a gene encoding an atypical asparaginase." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 7200, 558, 25, 201 ]

4

[]

0

true

Family

L-asparaginase II

Asparaginase_II

1

IPR010350

10,350

Thioredoxin-like ferredoxin, bacteria

Aim32/Apd1-like_bac

Family

1,415

false

This entry include a group of bacteria proteins that contain a ferredoxin-like fold and show protein sequence similarity to yeast Aim32/Apd1.

[]

0

[ "PIRSF" ]

[ "PIRSF035042" ]

[ "UCP035042_thirdx" ]

[ 1415 ]

1

[]

0

[]

0

[]

0

[ "IPR009737" ]

[]

1

0

1

[ "Bacteria", "freshwater metagenome" ]

[ 1403, 12 ]

2

[]

0

true

Family

Thioredoxin-like ferredoxin, bacteria

Aim32/Apd1-like_bac

6

IPR010351

10,351

Protein of unknown function DUF943

DUF943

Family

1,108

false

This family consists of several hypothetical membrane proteins mainly from Enterobacteria. Recently, it was proposed that members of this family along with members of [ ] should be recognised as a putative toxin-antitoxin pair in which [ ] is a homologue of Colicin M and [ ] acts as its cognate immunity protein [ ].

[]

0

[ "PFAM" ]

[ "PF06092" ]

[ "DUF943" ]

[ 1108 ]

1

[]

0

[]

0

[ "PUB00154362" ]

[ "38658795" ]

[ "Identification of type VI secretion system effector-immunity pairs using structural bioinformatics." ]

[ 2024 ]

1

[]

0

null

[ "Myoviridae sp. ct4xW4", "Pseudomonadota", "human gut metagenome" ]

[ 1, 1104, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF943

DUF943

8

IPR010353

10,353

Phenol 2-monooxygenase, auxiliary component DmpK

DmpK

Family

629

false

This family consists of several bacterial phenol hydroxylase subunit proteins, which are part of a multicomponent phenol hydroxylase, including Phenol 2-monooxygenase, auxiliary component DmpK from Pseudomonas sp. DmpK may be involved in the post-translational incorporation of iron into the oxygenase component of the p...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06099", "PIRSF000039" ]

[ "Phenol_hyd_sub", "Phenol_monooxy_K" ]

[ 629, 363 ]

2

[]

0

[]

0

[ "PUB00012263", "PUB00100322" ]

[ "7753034", "8995386" ]

[ "Localization and organization of phenol degradation genes of Pseudomonas putida strain H.", "On the role of DmpK, an auxiliary protein associated with multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600." ]

[ 1995, 1997 ]

2

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 619, 10 ]

2

[]

0

true

Family

Phenol 2-monooxygenase, auxiliary component DmpK

DmpK

8

IPR010354

10,354

Oleate hydratase

Oleate_hydratase

Family

5,099

false

Oleate hydratase catalyses the hydration of oleate at its cis-9-double bond to yield 10-hydroxyoctadecanoate. The hydration of unsaturated fatty acids is suggested to be a detoxification mechanism and a survival strategy for living in fatty acid-rich environments [ , ]. It also appears to play a role in bacterial virul...

[ "GO:0050151", "GO:0071949", "GO:0006631" ]

[ "oleate hydratase activity", "FAD binding", "fatty acid metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06100", "PTHR37417" ]

[ "MCRA", "" ]

[ 5099, 5044 ]

2

[ "EC" ]

[ "4.2.1.53" ]

[ "EC:4.2.1.53" ]

1

[ "4ia5", "4ia6", "4uir", "5odo", "5z70", "7kav", "7kaw", "7kax", "7kay", "7kaz", "8ur3", "8ur6", "8ur8", "9axe", "9iqa", "9iqi", "9iqj" ]

17

[ "PUB00062997", "PUB00062998", "PUB00062999" ]

[ "19465645", "22203098", "20145247" ]

[ "Oleate hydratase catalyzes the hydration of a nonactivated carbon-carbon bond.", "Biochemical characterization and FAD-binding analysis of oleate hydratase from Macrococcus caseolyticus.", "Myosin cross-reactive antigen of Streptococcus pyogenes M49 encodes a fatty acid double bond hydratase that plays a role ...

[ 2009, 2012, 2010 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 4147, 856, 65, 31 ]

4

[]

0

true

Family

Oleate hydratase

Oleate_hydratase

8

IPR010357

10,357

Thioredoxin domain-containing protein 17-like domain

TXNDC17_dom

Domain

3,932

false

This domain can be found in thioredoxin domain-containing protein 17 (also known as TRP14), which is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways. TXNDC17 has been shown to efficiently reduce l-cystine and can directly reactivate oxidized pro...

[]

0

[ "PFAM" ]

[ "PF06110" ]

[ "TXD17-like_Trx" ]

[ 3932 ]

1

[]

0

[ "1v9w", "1wou", "7xpw", "7xq3" ]

4

[ "PUB00098049" ]

[ "30129655" ]

[ "Thioredoxin-related protein of 14 kDa as a modulator of redox signalling pathways." ]

[ 2019 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3932 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 1, 2, 12, 5, 1, 1, 3, 1, 5 ]

10

true

Domain

Thioredoxin domain-containing protein 17-like domain

TXNDC17_dom

6

IPR010358

10,358

BRCA1-A complex subunit BRE

BRE

Family

2,468

false

Brain and reproductive organ-expressed (BRE, also known as BRCC45) is a component of the BRCA1-A complex, a complex that specifically recognises 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) [...

[ "GO:0070531", "GO:0070552" ]

[ "BRCA1-A complex", "BRISC complex" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06113", "PTHR15189" ]

[ "BRE", "" ]

[ 2373, 2423 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-5689901", "R-BTA-5693565", "R-BTA-5693571", "R-BTA-5693607", "R-BTA-69473", "R-GGA-5689901", "R-GGA-5693565", "R-GGA-5693571", "R-GGA-5693607", "R-GGA-69473", "R-HSA-5689901", "R-HSA-5693565", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-69473", "R-MMU-5689901", "R-MMU-5693565", ...

[ "REACTOME:R-BTA-5689901", "REACTOME:R-BTA-5693565", "REACTOME:R-BTA-5693571", "REACTOME:R-BTA-5693607", "REACTOME:R-BTA-69473", "REACTOME:R-GGA-5689901", "REACTOME:R-GGA-5693565", "REACTOME:R-GGA-5693571", "REACTOME:R-GGA-5693607", "REACTOME:R-GGA-69473", "REACTOME:R-HSA-5689901", "REACTOME:R-...

26

[ "6gvw", "6h3c", "6r8f", "8pvy", "8py2" ]

5

[ "PUB00054087", "PUB00060076", "PUB00081453", "PUB00081742", "PUB00081743", "PUB00084981", "PUB00084982" ]

[ "19214193", "19261748", "14636569", "26195665", "21282113", "24075985", "25283148" ]

[ "K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.", "MERIT40 facilitates BRCA1 localization and DNA damage repair.", "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.", "The deu...

[ 2009, 2009, 2003, 2015, 2011, 2013, 2014 ]

7

[]

0

null

[ "Eukaryota" ]

[ 2468 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 2, 6, 5, 2, 6, 8 ]

7

true

Family

BRCA1-A complex subunit BRE

BRE

8

IPR010359

10,359

IrrE N-terminal-like domain

IrrE_HExxH

Domain

30,544

false

This entry includes the catalytic domain of the protein ImmA (MEROPS identifier M78.001), which is a metallopeptidase containing an HEXXH zinc-binding motif. ImmA is encoded on a conjugative transposon. Conjugating bacteria are able to transfer conjugative transposons that can, for example, confer resistance to antibio...

[]

0

[ "PFAM" ]

[ "PF06114" ]

[ "Peptidase_M78" ]

[ 30544 ]

1

[]

0

[ "3dte", "3dti", "3dtk", "6cyj", "6cyy", "6cz6", "6d2s", "7t5t", "8slm", "8sln" ]

10

[ "PUB00051490", "PUB00066798", "PUB00074928", "PUB00074929" ]

[ "19150362", "18761623", "15090522", "22916289" ]

[ "Crystal structure of the IrrE protein, a central regulator of DNA damage repair in deinococcaceae.", "A conserved anti-repressor controls horizontal gene transfer by proteolysis.", "RamB, a novel transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum.", "A novel role ...

[ 2009, 2008, 2004, 2012 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 126, 29730, 18, 346, 324 ]

5

[]

0

true

Domain

IrrE N-terminal-like domain

IrrE_HExxH

7

IPR010360

10,360

Protein of unknown function DUF956

DUF956

Family

1,612

false

This is a family of bacterial sequences with undetermined function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06115", "PIRSF021265" ]

[ "DUF956", "DUF956" ]

[ 1612, 1370 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1608, 4 ]

2

[]

0

true

Family

Protein of unknown function DUF956

DUF956

2

IPR010363

10,363

Domain of unknown function DUF959, collagen XVIII, N-terminal

DUF959_COL18_N

Domain

338

false

The function of this collagen XVIII N-terminal domain has not been characterised. It is not expressed in the 'short' isoform of collagen XVIII [ ].

[]

0

[ "PFAM" ]

[ "PF06121" ]

[ "DUF959" ]

[ 338 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1442490", "R-HSA-1592389", "R-HSA-1650814", "R-HSA-2022090", "R-HSA-216083", "R-HSA-3000157", "R-HSA-8948216", "R-MMU-1442490", "R-MMU-1592389", "R-MMU-1650814", "R-MMU-2022090", "R-MMU-216083", "R-MMU-8948216" ]

[ "REACTOME:R-HSA-1442490", "REACTOME:R-HSA-1592389", "REACTOME:R-HSA-1650814", "REACTOME:R-HSA-2022090", "REACTOME:R-HSA-216083", "REACTOME:R-HSA-3000157", "REACTOME:R-HSA-8948216", "REACTOME:R-MMU-1442490", "REACTOME:R-MMU-1592389", "REACTOME:R-MMU-1650814", "REACTOME:R-MMU-2022090", "REACTOME...

13

[]

0

[ "PUB00012268" ]

[ "9503365" ]

[ "Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific differences in the expression of the corresponding transcripts." ]

[ 1998 ]

1

[]

0

null

[ "Euteleostomi" ]

[ 338 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 2 ]

3

true

Domain

Domain of unknown function DUF959, collagen XVIII, N-terminal

DUF959_COL18_N

8

IPR010364

10,364

Uncharacterised protein family, inner membrane CreD

Uncharacterised_IM_CreD

Family

4,595

false

This family consists of several bacterial CreD or Cet inner membrane proteins. Dominant mutations of the cet gene of Escherichia coli result in tolerance to colicin E2 and increased amounts of an inner membrane protein with a Mr of 42,000. The cet gene is shown to be in the same operon as the phoM gene, which is requir...

[]

0

[ "NCBIFAM", "PFAM", "PIRSF", "PANTHER" ]

[ "NF008712", "PF06123", "PIRSF004548", "PTHR30092" ]

[ "PRK11715.1-1", "CreD", "CreD", "" ]

[ 4226, 4595, 4096, 4534 ]

4

[]

0

[]

0

[ "PUB00012269", "PUB00104759" ]

[ "2835585", "31451505" ]

[ "Identification and sequencing of the Escherichia coli cet gene which codes for an inner membrane protein, mutation of which causes tolerance to colicin E2.", "CreC Sensor Kinase Activation Enhances Growth of Escherichia coli in the Presence of Cephalosporins and Carbapenems." ]

[ 1988, 2019 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4545, 9, 41 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family, inner membrane CreD

Uncharacterised_IM_CreD

2

IPR010365

10,365

Protein of unknown function DUF961

DUF961

Family

1,986

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06125" ]

[ "DUF961" ]

[ 1986 ]

1

[]

0

[ "2k5d" ]

1

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 1974, 4, 8 ]

3

[]

0

true

Family

Protein of unknown function DUF961

DUF961

5

IPR010366

10,366

Arginine ADP-riboxanase OspC1-4

OspC1-4

Family

139

false

This family represents Arginine ADP-riboxanase OspC1-4, found in Proteobacteria. OspC1-4 are ADP-riboxanase effectors that inhibit host cell pyroptosis [ , , ].

[]

0

[ "PFAM" ]

[ "PF06128" ]

[ "Shigella_OspC" ]

[ 139 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "4.3.99.-", "PWY-8106", "PWY-8337" ]

[ "EC:4.3.99.-", "METACYC:PWY-8106", "METACYC:PWY-8337" ]

3

[ "7wr1", "7wr2", "7wr3", "7wr4", "7wr5", "7wzs", "7xn4", "7xn5", "7xn6", "8j6k" ]

10

[ "PUB00100323", "PUB00100324", "PUB00101362" ]

[ "34409271", "34671164", "35338844" ]

[ "Shigella OspC3 suppresses murine cytosolic LPS sensing.", "Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11.", "Pathogen hijacks programmed cell death signaling by arginine ADPR-deacylization of caspases." ]

[ 2021, 2021, 2022 ]

3

[]

0

null

[ "Pseudomonadota", "viral metagenome" ]

[ 138, 1 ]

2

[]

0

true

Family

Arginine ADP-riboxanase OspC1-4

OspC1-4

8

IPR010367

10,367

Poxvirus G3

Poxvirus_G3

Family

113

false

This entry represents G3 from Vaccinia virus, also called Entry-fusion complex protein OPG086, and similar proteins from poxvirus. G3 is a component of the entry fusion complex (EFC), which consists of 11 proteins. During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-st...

[]

0

[ "PFAM" ]

[ "PF06129" ]

[ "Chordopox_G3" ]

[ 113 ]

1

[]

0

[ "7ytt", "7ytu" ]

2

[ "PUB00034709", "PUB00103595" ]

[ "16339313", "34076488" ]

[ "Poxvirus multiprotein entry-fusion complex.", "Insights into the Organization of the Poxvirus Multicomponent Entry-Fusion Complex from Proximity Analyses in Living Infected Cells." ]

[ 2005, 2021 ]

2

[]

0

null

[ "Chitinophaga niabensis", "Poxviridae" ]

[ 1, 112 ]

2

[]

0

true

Family

Poxvirus G3

Poxvirus_G3

2

IPR010368

10,368

Control of competence regulator ComK, YlbF/YmcA

Com_YlbF

Family

8,498

false

This entry consists of several relatively short bacterial and archaeal hypothetical sequences. It also includes YlbF and YmcA proteins which are involved in the formation of biofilms [ ]. YlbF Is a family of short Gram-positive and archaeal proteins that includes both YlbF and YmcA which may interact synergistically. T...

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_01526", "PF06133" ]

[ "UPF0342", "Com_YlbF" ]

[ 2729, 8498 ]

2

[]

0

[ "2iaz", "2oee", "2oeq", "2pih", "6prh", "6prk" ]

6

[ "PUB00043614", "PUB00075458", "PUB00075459" ]

[ "15175311", "23490197", "19202088" ]

[ "Genes involved in formation of structured multicellular communities by Bacillus subtilis.", "A complex of YlbF, YmcA and YaaT regulates sporulation, competence and biofilm formation by accelerating the phosphorylation of Spo0A.", "Identification of genes required for different stages of dendritic swarming in B...

[ 2004, 2013, 2009 ]

3

[]

[ "IPR016783" ]

0

1

0

[ "Bacteria", "Methanobacteriati", "Phytophthora", "metagenomes" ]

[ 8111, 342, 2, 43 ]

4

[]

0

true

Family

Control of competence regulator ComK, YlbF/YmcA

Com_YlbF

5

IPR010369

10,369

Protein SOSEKI

SOK

Family

3,796

false

This entry represents a group of plant-specific proteins, including protein SOSEKI 1-5 from Arabidopsis thaliana and Physcomitrium patens. SOSEKI proteins (SOK1-5) integrate apical-basal and radial organismal axes to localize to polar cell edges and contain a DIX oligomerization domain that resembles that in the animal...

[]

0

[ "PANTHER" ]

[ "PTHR31083" ]

[ "" ]

[ 3796 ]

1

[]

0

[ "6rsn" ]

1

[ "PUB00096646", "PUB00096647" ]

[ "32004461", "30737509" ]

[ "DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes.", "A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis." ]

[ 2020, 2019 ]

2

[]

[ "IPR021182" ]

0

1

0

[ "Embryophyta" ]

[ 3796 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 27, 22, 46 ]

3

true

Family

Protein SOSEKI

SOK

9

IPR010371

10,371

YBR137W-like

Family

5,230

false

This entry represents a family of proteins from bacteria and some fungal species, including YBR137W from Saccharomyces cerevisiae ( ). This protein may play a role in the regulation of tail-anchored (TA) protein targeting. It shows an antiparallel β-sheet made of four β-strands surrounded by seven α-helices [ , ].

[]

0

[ "HAMAP", "PIRSF", "PANTHER" ]

[ "MF_00761", "PIRSF008757", "PTHR28255" ]

[ "UPF0303", "UCP008757", "" ]

[ 2442, 3760, 5228 ]

3

[]

0

[ "4clc" ]

1

[ "PUB00100961", "PUB00100962" ]

[ "20850366", "25288638" ]

[ "A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum.", "Structural and functional characterization of ybr137wp implicates its involvement in the targeting of tail-anchored proteins to membranes." ]

[ 2010, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3649, 1522, 59 ]

3

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

YBR137W-like

7

IPR010374

10,374

Protein of unknown function DUF969

DUF969

Family

3,320

false

This is a family of uncharacterised bacterial membrane proteins.

[]

0

[ "PFAM" ]

[ "PF06149" ]

[ "DUF969" ]

[ 3320 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Linnemannia gamsii", "Thermococcus aggregans", "metagenomes" ]

[ 3307, 1, 1, 11 ]

4

[]

0

true

Family

Protein of unknown function DUF969

DUF969

5

IPR010375

10,375

Cyclic-di-AMP receptor

CdAMP_rec

Family

3,534

false

CdAMP is a family of bacterial cyclic-di-AMP receptor proteins. Cyclic-di-AMP (c-di-AMP) is a bacterial secondary messenger involved in various processes, including sensing of DNA-integrity, cell wall metabolism and potassium transport. CdAMP_rec has a ferredoxin-like fold and is structurally related to Pii-signal tran...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06153", "PTHR38456" ]

[ "CdAMP_rec", "" ]

[ 3534, 3508 ]

2

[]

0

[ "3m05", "4d3g", "4d3h", "4rle", "4rww", "4rwx", "4wk1", "4wk3" ]

8

[ "PUB00075460" ]

[ "25435171" ]

[ "c-di-AMP recognition by Staphylococcus aureus PstA." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "unclassified sequences" ]

[ 3505, 1, 28 ]

3

[]

0

true

Family

Cyclic-di-AMP receptor

CdAMP_rec

3

IPR010376

10,376

Gamma-butyrobetaine hydroxylase-like, N-terminal

GBBH-like_N

Domain

14,342

false

Gamma-butyrobetaine hydroxylase (GBBH/BBOX) is an alpha-ketoglutarate-dependent dioxygenase that catalyses the biosynthesis of L-carnitine by hydroxylation of gamma-butyrobetaine (GBB). GBBH is a dimeric enzyme. The monomer consists of a catalytic double-stranded β-helix domain and a smaller N-terminal domain. The N-te...

[]

0

[ "PFAM" ]

[ "PF06155" ]

[ "GBBH-like_N" ]

[ 14342 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.11", "R-BTA-71262", "R-GGA-71262", "R-HSA-71262", "R-MMU-71262", "R-RNO-71262" ]

[ "EC:1.14.11", "REACTOME:R-BTA-71262", "REACTOME:R-GGA-71262", "REACTOME:R-HSA-71262", "REACTOME:R-MMU-71262", "REACTOME:R-RNO-71262" ]

6

[ "2l6n", "2l6p", "3luu", "3ms5", "3n6w", "3o2g", "4bg1", "4bgk", "4bgm", "4bhf", "4bhg", "4bhi", "4c5w", "4c8r", "4cwd", "6npb", "6npc", "6npd", "9j0j" ]

19

[ "PUB00075680", "PUB00103931" ]

[ "20599753", "30789718" ]

[ "Crystal structure of human gamma-butyrobetaine hydroxylase.", "A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases." ]

[ 2010, 2019 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Mimiviridae", "unclassified sequences" ]

[ 16, 7156, 6932, 2, 236 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 10, 1, 3, 9, 4, 3, 2, 8, 5, 13 ]

10

true

Domain

Gamma-butyrobetaine hydroxylase-like, N-terminal

GBBH-like_N

1

IPR010377

10,377

Replication initiation control protein YabA

YabA

Family

2,895

false

YabA is involved in initiation control of chromosome replication [ ]. It interacts with both DnaA and DnaN, acting as a bridge between these two proteins [ ].

[ "GO:0006260" ]

[ "DNA replication" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM", "PIRSF" ]

[ "MF_01159", "PF06156", "PIRSF021439" ]

[ "YabA", "YabA", "DUF972" ]

[ 1921, 2895, 2818 ]

3

[]

0

[ "5dol" ]

1

[ "PUB00056588", "PUB00070825" ]

[ "12060778", "18506095" ]

[ "An expanded view of bacterial DNA replication.", "The functional analysis of YabA, which interacts with DnaA and regulates initiation of chromosome replication in Bacillus subtils." ]

[ 2002, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Thermococcus", "metagenomes" ]

[ 2881, 6, 4, 4 ]

4

[]

0

true

Family

Replication initiation control protein YabA

YabA

3

IPR010378

10,378

Trafficking protein particle complex subunit 13

TRAPPC13

Family

5,634

false

Three transport protein particle (TRAPP) complexes exist in yeast (TRAPPI-TRAPPIII), which share a common core in addition to unique subunits. TRAPPI-TRAPPIII regulate endoplasmic reticulum (ER)-to-Golgi transport, intra-Golgi transport and autophagy, respectively. TRAPPC composition seems to be more complex in higher ...

[]

0

[ "PANTHER" ]

[ "PTHR13134" ]

[ "" ]

[ 5634 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-8876198", "R-CEL-8876198", "R-DDI-8876198", "R-DME-8876198", "R-HSA-8876198", "R-MMU-8876198", "R-RNO-8876198" ]

[ "REACTOME:R-BTA-8876198", "REACTOME:R-CEL-8876198", "REACTOME:R-DDI-8876198", "REACTOME:R-DME-8876198", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-8876198", "REACTOME:R-RNO-8876198" ]

7

[]

0

[ "PUB00090991", "PUB00090992" ]

[ "28536105", "21453443" ]

[ "TRAPPC13 modulates autophagy and the response to Golgi stress.", "Organization and assembly of the TRAPPII complex." ]

[ 2017, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5634 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 4, 1, 4, 2, 1, 5, 6, 7 ]

10

true

Family

Trafficking protein particle complex subunit 13

TRAPPC13

6

IPR010379

10,379

Septation ring formation regulator EzrA

EzrA

Family

3,149

false

During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerises into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation [ ].

[ "GO:0000921", "GO:0005940", "GO:0016020" ]

[ "septin ring assembly", "septin ring", "membrane" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "HAMAP", "PFAM" ]

[ "MF_00728", "PF06160" ]

[ "EzrA", "EzrA" ]

[ 2656, 3149 ]

2

[]

0

[ "4uxv", "4uy3" ]

2

[ "PUB00012275" ]

[ "10449747" ]

[ "Identification and characterization of a negative regulator of FtsZ ring formation in Bacillus subtilis." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 3135, 6, 8 ]

3

[]

0

true

Family

Septation ring formation regulator EzrA

EzrA

7

IPR010380

10,380

Protein of unknown function DUF975

DUF975

Family

6,260

false

Family of uncharacterised bacterial proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06161", "PTHR40076" ]

[ "DUF975", "" ]

[ 4773, 6150 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 6147, 11, 23, 3, 76 ]

5

[]

0

true

Family

Protein of unknown function DUF975

DUF975

6

IPR010382

10,382

Protein of unknown function DUF977

DUF977

Family

1,427

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06163" ]

[ "DUF977" ]

[ 1427 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Anoplophora glabripennis", "Bacteria", "Methanobacteriota", "Viruses", "metagenomes" ]

[ 1, 1415, 3, 3, 5 ]

5

[]

0

true

Family

Protein of unknown function DUF977

DUF977

7

IPR010383

10,383

Glycosyl hydrolase 94, supersandwich domain

Glyco_hydrolase_94_b-supersand

Domain

6,327

false

This entry represents a β-supersandwich domain found in the superfamily of enzymes referred to as GH94, formerly known as glycosyltransferase family GT36 [ ]. Family 94 of glycoside hydrolases exclusively contains phosphorylases that cleave beta-glycosidic bonds. The substrate specificities found in this family are: ce...

[]

0

[ "PFAM" ]

[ "PF06165" ]

[ "GH94_b-supersand" ]

[ 6327 ]

1

[ "CAZY" ]

[ "GT36" ]

[ "CAZY:GT36" ]

1

[ "1v7v", "1v7w", "1v7x", "2cqs", "2cqt", "3acs", "3act", "3afj", "3qde", "3qfy", "3qfz", "3qg0", "3rrs", "3rsy", "3s4a", "3s4b", "3s4c", "3s4d", "4zle", "4zlf", "4zlg", "4zli", "5nz7", "5nz8", "6ggy", "6gh2", "6gh3", "8bou", "8h6h", "8hnu", "8ho7", "8ho8"...

43

[ "PUB00032019" ]

[ "15274915" ]

[ "Chitobiose phosphorylase from Vibrio proteolyticus, a member of glycosyl transferase family 36, has a clan GH-L-like (alpha/alpha)(6) barrel fold." ]

[ 2004 ]

1

[]

[ "IPR037814", "IPR037820", "IPR037824", "IPR037825", "IPR037828" ]

0

5

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 25, 5960, 259, 83 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Glycosyl hydrolase 94, supersandwich domain

Glyco_hydrolase_94_b-supersand

4

IPR010384

10,384

MtfA family

MtfA_fam

Family

6,676

false

Mlc titration factor A (MtfA, previously known as YeeI) is a transcription factor A that binds Mlc (make large colonies), itself a repressor of glucose and hence a protein important in regulation of the phosphoenolpyruvate:glucose-phosphotransferase (ptsG) system, the major glucose transporter in E. coli. Mlc is a repr...

[]

0

[ "PFAM", "PANTHER", "CDD" ]

[ "PF06167", "PTHR30164", "cd20169" ]

[ "Peptidase_M90", "", "Peptidase_M90_mtfA" ]

[ 6675, 6632, 5904 ]

3

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.4.11.-", "PWY-6423", "PWY-7694", "PWY-7954" ]

[ "EC:3.4.11.-", "METACYC:PWY-6423", "METACYC:PWY-7694", "METACYC:PWY-7954" ]

4

[ "3dl1", "3khi" ]

2

[ "PUB00054592", "PUB00066805" ]

[ "16855233", "22178967" ]

[ "YeeI, a novel protein involved in modulation of the activity of the glucose-phosphotransferase system in Escherichia coli K-12.", "Characterization of MtfA, a novel regulatory output signal protein of the glucose-phosphotransferase system in Escherichia coli K-12." ]

[ 2006, 2012 ]

2

[]

[ "IPR057256" ]

0

1

0

[ "Bacteria", "Eukaryota", "Rhodovirinae", "unclassified sequences" ]

[ 6572, 14, 2, 88 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

MtfA family

MtfA_fam

4

IPR010385

10,385

Protein of unknown function DUF982

DUF982

Family

4,468

false

This family consists of several hypothetical proteins from Proteobacterial species. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06169" ]

[ "DUF982" ]

[ 4468 ]

1

[]

0

[ "2kpq" ]

1

[]

0

[]

0

null

[ "Alphaproteobacteria", "Viruses", "metagenomes" ]

[ 4464, 2, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF982

DUF982

3

IPR010387

10,387

Queuosine precursor transporter QueT

QueT

Family

3,703

false

This family includes the queT gene encoding a hypothetical integral membrane protein with 5 predicted transmembrane regions. The queT genes in Firmicutes are often preceded by the PreQ1 (7-aminomethyl-7-deazaguanine) riboswitches of two distinct classes [ , ], suggesting involvement of the QueT transporters in uptake o...

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06177", "PIRSF031501", "PTHR40044" ]

[ "QueT", "QueT", "" ]

[ 3701, 3295, 3558 ]

3

[ "GP" ]

[ "GenProp1094" ]

[ "GP:GenProp1094" ]

1

[]

0

[ "PUB00044767", "PUB00044768" ]

[ "17384645", "18305186" ]

[ "A riboswitch selective for the queuosine precursor preQ1 contains an unusually small aptamer domain.", "Confirmation of a second natural preQ1 aptamer class in Streptococcaceae bacteria." ]

[ 2007, 2008 ]

2

[]

0

null

[ "Archaea", "Bacteria", "metagenomes", "unclassified Caudoviricetes" ]

[ 96, 3553, 51, 3 ]

4

[]

0

true

Family

Queuosine precursor transporter QueT

QueT

1

IPR010389

10,389

Urate oxidase N-terminal

Urate_ox_N

Domain

5,161

false

Cytochrome c urate oxidase (Uox) PuuD is involved in purine degradation. In contrast with soluble Uox it is a membrane protein with an 8-helix transmembrane N-terminal domain and a C-terminal cytochrome c [ ].

[]

0

[ "PFAM" ]

[ "PF06181" ]

[ "Urate_ox_N" ]

[ 5161 ]

1

[]

0

[]

0

[ "PUB00081215" ]

[ "26349049" ]

[ "The identification of an integral membrane, cytochrome c urate oxidase completes the catalytic repertoire of a therapeutic enzyme." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4973, 7, 181 ]

3

[]

0

true

Domain

Urate oxidase N-terminal

Urate_ox_N

2

IPR010390

10,390

ABC-2 transporter-like

ABC-2_transporter-like

Family

14,018

false

This entry represents a family that acts as the transmembrane domain (TMD) of ABC transporters [ , ]. The family includes proteins responsible for the transport of herbicides [ ].

[]

0

[ "PFAM" ]

[ "PF06182" ]

[ "ABC2_membrane_6" ]

[ 14018 ]

1

[]

0

[]

0

[ "PUB00101288", "PUB00101289" ]

[ "19594831", "20030718" ]

[ "A novel ATP-binding cassette transporter is responsible for resistance to viologen herbicides in the cyanobacterium Synechocystis sp. PCC 6803.", "Identification of a novel ABC transporter required for desiccation tolerance, and biofilm formation in Rhizobium leguminosarum bv. viciae 3841." ]

[ 2009, 2010 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Sar", "unclassified sequences" ]

[ 10, 13942, 3, 63 ]

4

[]

0

true

Family

ABC-2 transporter-like

ABC-2_transporter-like

7

IPR010391

10,391

DNA damage-inducible protein DinI-like

DNA_damage-inducible_DinI-like

Family

4,980

false

This family of short proteins includes DNA-damage-inducible protein I (DinI) and related proteins. The SOS response, a set of cellular phenomena exhibited by eubacteria, is initiated by various causes that include DNA damage-induced replication arrest, and is positively regulated by the co- protease activity of RecA. E...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06183", "PTHR36572" ]

[ "DinI", "" ]

[ 4794, 4762 ]

2

[]

0

[ "1ghh", "7ywa" ]

2

[ "PUB00012280", "PUB00012281" ]

[ "12626715", "11152126" ]

[ "An NMR study on the interaction of Escherichia coli DinI with RecA-ssDNA complexes.", "Solution structure of DinI provides insight into its mode of RecA inactivation." ]

[ 2003, 2000 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 4931, 7, 37, 5 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA damage-inducible protein DinI-like

DNA_damage-inducible_DinI-like

1

IPR010392

10,392

Satellite virus coat

Satellite_virus_coat

Family

254

false

This entry represents coat proteins found in several satellite viruses, including satellite panicum mosaic virus [ ], satellite tobacco necrosis virus, and satellite St. Augustine decline virus. The coat proteins of satellite viruses consist of a β-sandwich jelly-roll fold, with usually eight strands making up the two ...

[ "GO:0005198", "GO:0019028" ]

[ "structural molecule activity", "viral capsid" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PFAM" ]

[ "PF03898", "PF06184" ]

[ "TNV_CP", "Potex_coat" ]

[ 38, 216 ]

2

[]

0

[ "1stm", "2buk", "3s4g", "4bcu", "4v4m", "5cvz", "5cw0", "8qkm", "9qve" ]

9

[ "PUB00007874", "PUB00020147" ]

[ "8553559", "7552713" ]

[ "Structural comparison of the plant satellite viruses.", "The structure of satellite panicum mosaic virus at 1.9 A resolution." ]

[ 1995, 1995 ]

2

[]

[ "IPR005597" ]

0

1

0

[ "Antarctic circular DNA molecule", "Candidatus Magnetobacterium casense", "Ecdysozoa", "Viruses" ]

[ 4, 1, 4, 245 ]

4

[]

0

true

Family

Satellite virus coat

Satellite_virus_coat

7

IPR010393

10,393

Protein of unknown function DUF991, YecM-like

DUF991_YecM-like

Family

2,282

false

This family incudes Protein YecM from Escherichia coli and similar proteins predominantly found in gammaproteobacteria. YecM shows a pseudo-twofold axis with eight β-strands forming a curved sheet that wraps around C-terminal α-helix and a presumed active site, forming a deep groove, and two α-helices on each side of t...

[]

0

[ "PFAM", "PANTHER", "CDD" ]

[ "PF06185", "PTHR37519", "cd07268" ]

[ "YecM", "", "VOC_EcYecM_like" ]

[ 2282, 2253, 1042 ]

3

[]

0

[ "1k4n" ]

1

[ "PUB00021075", "PUB00087014" ]

[ "12660999", "21820381" ]

[ "Conserved protein YecM from Escherichia coli shows structural homology to metal-binding isomerases and oxygenases.", "Structural and mechanistic comparisons of the metal-binding members of the vicinal oxygen chelate (VOC) superfamily." ]

[ 2003, 2011 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2210, 68, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF991, YecM-like

DUF991_YecM-like

7

IPR010394

10,394

5-nucleotidase

Family

6,469

false

This family consists of both eukaryotic and prokaryotic 5'-nucleotidase sequences ( ), including cytosolic 5'-nucleotidase 1A and 1B (NT5C1A/NT5C1B) from mammals. NT5C1A/NT5C1B dephosphorylate the 5' and 2'(3')-phosphates of deoxyribonucleotides and help to regulate adenosine levels [ ].

[ "GO:0000166", "GO:0000287", "GO:0008253", "GO:0009117", "GO:0005737" ]

[ "nucleotide binding", "magnesium ion binding", "5'-nucleotidase activity", "nucleotide metabolic process", "cytoplasm" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PFAM", "PANTHER" ]

[ "PF06189", "PTHR31367" ]

[ "5-nucleotidase", "" ]

[ 6468, 6424 ]

2

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3.5", "GenProp1255", "PWY-5381", "PWY-5695", "PWY-6596", "PWY-6606", "PWY-6607", "PWY-6608", "PWY-7185", "PWY-7821", "R-HSA-73621", "R-HSA-74259", "R-MMU-73621", "R-MMU-74259" ]

[ "EC:3.1.3.5", "GP:GenProp1255", "METACYC:PWY-5381", "METACYC:PWY-5695", "METACYC:PWY-6596", "METACYC:PWY-6606", "METACYC:PWY-6607", "METACYC:PWY-6608", "METACYC:PWY-7185", "METACYC:PWY-7821", "REACTOME:R-HSA-73621", "REACTOME:R-HSA-74259", "REACTOME:R-MMU-73621", "REACTOME:R-MMU-74259" ]

14

[]

0

[ "PUB00086689" ]

[ "11133996" ]

[ "Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3209, 3193, 67 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 9, 17, 7 ]

4

true

Family

5-nucleotidase

3

IPR010396

10,396

Poxvirus A4L

Poxvirus_A4L

Family

176

false

This entry represents A4L from Vaccinia virus, also called 39kDa core protein OPG130 (p39), and similar proteins predominantly found in orthopoxvirus. A4L is a component of the virion core that participates in virion assembly [ , ].

[]

0

[ "PFAM" ]

[ "PF06193" ]

[ "Orthopox_A5L" ]

[ 176 ]

1

[]

0

[ "8r5i" ]

1

[ "PUB00012284", "PUB00103669", "PUB00103670" ]

[ "10233918", "11799179", "10600608" ]

[ "Vaccinia virus WR gene A5L is required for morphogenesis of mature virions.", "Endoplasmic reticulum-Golgi intermediate compartment membranes and vimentin filaments participate in vaccinia virus assembly.", "The vaccinia virus 39-kDa protein forms a stable complex with the p4a/4a major core protein early in mo...

[ 1999, 2002, 1999 ]

3

[]

0

null

[ "Chordopoxvirinae", "Kushneria pakistanensis" ]

[ 175, 1 ]

2

[]

0

true

Family

Poxvirus A4L

Poxvirus_A4L

1

IPR010397

10,397

Protein of unknown function DUF996

DUF996

Family

233

false

This is a family of uncharacterised bacterial and archaeal proteins. This entry includes Uncharacterized protein MJ1644 from Methanocaldococcus jannaschi.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06195", "PIRSF019678" ]

[ "DUF996", "UCP019678" ]

[ 233, 26 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "marine sediment metagenome" ]

[ 146, 84, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF996

DUF996

5

IPR010399

10,399

Tify domain

Tify_dom

Domain

12,033

false

The tify domain is a 36-amino acid domain only found among Embryophyta (land plants). It has been named after the most conserved amino acid pattern (TIF[F/Y]XG) it contains, but was previously known as the Zim domain. As the use of uppercase characters (TIFY) might imply that the domain is fully conserved across protei...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF06200", "PS51320", "SM00979" ]

[ "tify", "TIFY", "TIFY" ]

[ 11827, 11970, 11503 ]

3

[]

0

[ "8t2i" ]

1

[ "PUB00020596", "PUB00043675", "PUB00043676", "PUB00043677" ]

[ "10945256", "17499004", "14966217", "16916932" ]

[ "Characterization of a novel gene encoding a putative single zinc-finger protein, ZIM, expressed during the reproductive phase in Arabidopsis thaliana.", "The tify family previously known as ZIM.", "Characterization of Arabidopsis ZIM, a member of a novel plant-specific GATA factor gene family.", "PEAPOD regu...

[ 2000, 2007, 2004, 2006 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 19, 12014 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 103, 41, 185 ]

3

true

Domain

Tify domain

Tify_dom

9

IPR010400

10,400

PITH domain

PITH_dom

Domain

9,297

false

This entry represents the PITH domain (derived from Proteasome-Interacting THioredoxin). The protein Txnl1, which is a probable component of the 32kDa 26S proteasome, uses its C-terminal PITH domain to associate specifically with the 26S proteasome [ ]. The PITH domain is dominated by a jelly roll β-sandwich structure....

[]

0

[ "PFAM", "PROFILE" ]

[ "PF06201", "PS51532" ]

[ "PITH", "PITH" ]

[ 9272, 9235 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-9013418", "R-HSA-9013420", "R-HSA-9013422", "R-HSA-9013424", "R-HSA-9696264", "R-HSA-9696270", "R-HSA-9696273", "R-MMU-9013418", "R-MMU-9013420", "R-MMU-9013422", "R-MMU-9013424", "R-MMU-9696264", "R-MMU-9696270", "R-MMU-9696273", "R-RNO-9013418", "R-RNO-9013420", "R-RNO-90134...

[ "REACTOME:R-HSA-9013418", "REACTOME:R-HSA-9013420", "REACTOME:R-HSA-9013422", "REACTOME:R-HSA-9013424", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9696270", "REACTOME:R-HSA-9696273", "REACTOME:R-MMU-9013418", "REACTOME:R-MMU-9013420", "REACTOME:R-MMU-9013422", "REACTOME:R-MMU-9013424", "REACTOM...

25

[ "1wwy", "1xoy", "9bw4", "9e8g", "9e8h", "9e8i", "9e8j", "9e8l", "9e8o" ]

9

[ "PUB00038340", "PUB00053806", "PUB00057965" ]

[ "15741346", "19349277", "20455272" ]

[ "Solution structure of At3g04780.1-des15, an Arabidopsis thaliana ortholog of the C-terminal domain of human thioredoxin-like protein.", "Thioredoxin Txnl1/TRP32 is a redox-active cofactor of the 26 S proteasome.", "Solution structure of the C-terminal DUF1000 domain of the human thioredoxin-like 1 protein." ]

[ 2005, 2009, 2010 ]

3

[]

0

null

[ "Eukaryota" ]

[ 9297 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 8, 2, 3, 4, 12, 11, 2, 6, 11, 2, 22 ]

11

true

Domain

PITH domain

PITH_dom

4

IPR010401

10,401

Glycogen debranching enzyme

AGL/Gdb1

Family

7,986

false

This family includes human glycogen branching enzyme AGL [ ] and yeast Gdb1 [ ]. This enzyme contains a number of distinct catalytic activities. In Saccharomyces cerevisiae, Gdb1 is a multifunctional enzyme that acts as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in gly...

[ "GO:0004134", "GO:0004135", "GO:0005980" ]

[ "4-alpha-glucanotransferase activity", "amylo-alpha-1,6-glucosidase activity", "glycogen catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PANTHER" ]

[ "PTHR10569" ]

[ "" ]

[ 7986 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.1.25", "3.2.1.33", "PWY-5941", "PWY-6724", "PWY-6737", "PWY-7238", "R-HSA-6798695", "R-HSA-70221", "R-SCE-6798695", "R-SCE-70221" ]

[ "EC:2.4.1.25", "EC:3.2.1.33", "METACYC:PWY-5941", "METACYC:PWY-6724", "METACYC:PWY-6737", "METACYC:PWY-7238", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-70221", "REACTOME:R-SCE-6798695", "REACTOME:R-SCE-70221" ]

10

[ "5d06", "5d0f", "7eim", "7ejp", "7ejt", "7eku", "7ekw", "7ekx", "8zeq" ]

9

[ "PUB00068064", "PUB00068065", "PUB00068066" ]

[ "17908927", "21585652", "11094287" ]

[ "A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.", "The Saccharomyces cerevisiae fermentation stress response protein Igd1p/Yfr017p regulates glycogen levels by inhibiting the glycogen debranching enzyme.", "The Saccharomyces cerevisiae YPR184w gene encodes the glyc...

[ 2007, 2011, 2000 ]

3

[]

[ "IPR006421", "IPR006451" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 191, 2706, 5026, 63 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 14, 9, 4, 7, 1, 2, 1 ]

8

true

Family

Glycogen debranching enzyme

AGL/Gdb1

3

IPR010402

10,402

CCT domain

CCT_domain

Domain

23,318

false

The CCT (CONSTANS, CO-like, and TOC1) domain is a highly conserved basic module of ~43 amino acids, which is found near the C terminus of plant proteins often involved in light signal transduction. The CCT domain is found in association with other domains, such as the B-box zinc finger, the GATA-type zinc finger, the Z...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF06203", "PS51017" ]

[ "CCT", "CCT" ]

[ 23236, 23051 ]

2

[ "PROSITEDOC" ]

[ "PDOC51017" ]

[ "PROSITEDOC:PDOC51017" ]

1

[ "7c9o", "7cvo", "7cvq" ]

3

[ "PUB00012285" ]

[ "10926537" ]

[ "Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota", "viral metagenome" ]

[ 23317, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 201, 161, 291 ]

3

true

Domain

CCT domain

CCT_domain

1

IPR010404

10,404

Chromophore lyase CpcT/CpeT

CpcT/CpeT

Family

2,046

false

This entry represents the CpcT/CpeT biliprotein lyase, which has been shown to covalently attach chromophores to cystiene residue(s) of phycobiliproteins [ , ]. These proteins contain a conserved motif PYR in the amino terminal half of the protein that may be functionally important. In the chromatically adapting cyanob...

[ "GO:0016829", "GO:0017009" ]

[ "lyase activity", "protein-phycocyanobilin linkage" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PANTHER", "CDD" ]

[ "MF_01460", "PF06206", "PTHR35137", "cd16338" ]

[ "Chrphore_lyase_CpxT", "CpeT", "", "CpcT" ]

[ 807, 2024, 1722, 1729 ]

4

[]

0

[ "4o4o", "4o4s", "5hi8", "6lix", "6liy" ]

5

[ "PUB00053876", "PUB00056794", "PUB00056796" ]

[ "12067341", "17895251", "16644722" ]

[ "CpeR is an activator required for expression of the phycoerythrin operon (cpeBA) in the cyanobacterium Fremyella diplosiphon and is encoded in the phycoerythrin linker-polypeptide operon (cpeCDESTR).", "Lyase activities of CpcS- and CpcT-like proteins from Nostoc PCC7120 and sequential reconstitution of binding ...

[ 2002, 2007, 2006 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "ecological metagenomes" ]

[ 1073, 74, 897, 2 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 3, 7 ]

3

true

Family

Chromophore lyase CpcT/CpeT

CpcT/CpeT

8

IPR010405

10,405

Cofactor of BRCA1

COBRA1

Family

2,178

false

This family consists of several cofactor of BRCA1 (COBRA1) proteins (also known as negative elongation factor B). It is thought that COBRA1 along with BRCA1 is involved in chromatin unfolding. COBRA1 is recruited to the chromosome site by the first BRCT repeat of BRCA1, and is itself sufficient to induce chromatin unfo...

[ "GO:0045892", "GO:0005634" ]

[ "negative regulation of DNA-templated transcription", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06209", "PTHR13503" ]

[ "COBRA1", "" ]

[ 2072, 2160 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-112382", "R-DME-113418", "R-DME-674695", "R-DME-6796648", "R-DME-75955", "R-HSA-112382", "R-HSA-113418", "R-HSA-167152", "R-HSA-167158", "R-HSA-167200", "R-HSA-167238", "R-HSA-167242", "R-HSA-167243", "R-HSA-167246", "R-HSA-167287", "R-HSA-167290", "R-HSA-674695", "R-HSA-679...

[ "REACTOME:R-DME-112382", "REACTOME:R-DME-113418", "REACTOME:R-DME-674695", "REACTOME:R-DME-6796648", "REACTOME:R-DME-75955", "REACTOME:R-HSA-112382", "REACTOME:R-HSA-113418", "REACTOME:R-HSA-167152", "REACTOME:R-HSA-167158", "REACTOME:R-HSA-167200", "REACTOME:R-HSA-167238", "REACTOME:R-HSA-167...

25

[ "6gml", "7pks", "7ycx", "8jj6", "8rbx", "8uha", "8uhd", "8uhg", "8ui0", "8w8e", "9j0n", "9j0o", "9j0p", "9vd9" ]

14

[ "PUB00012287" ]

[ "11739404" ]

[ "BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2178 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 4, 3 ]

5

true

Family

Cofactor of BRCA1

COBRA1

7

IPR010406

10,406

Protein of unknown function DUF1003

DUF1003

Family

9,050

false

This entry consists of several hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06210", "PTHR41386" ]

[ "DUF1003", "" ]

[ 9046, 8167 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "uncultured Caudovirales phage" ]

[ 10, 8808, 25, 206, 1 ]

5

[]

0

true

Family

Protein of unknown function DUF1003

DUF1003

4

IPR010407

10,407

Signaling lymphocytic activation molecule, N-terminal

Sig_lymph_act_molc_N

Domain

350

false

This entry is found in several mammalian signalling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70kDa co-stimulatory molecule belonging to the Ig superfamily, is defined ...

[ "GO:0038023", "GO:0046649", "GO:0009986", "GO:0016020" ]

[ "signaling receptor activity", "lymphocyte activation", "cell surface", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF06214" ]

[ "SLAM" ]

[ 350 ]

1

[]

0

[ "3alw", "3alx", "3alz" ]

3

[ "PUB00012290", "PUB00012291" ]

[ "10570270", "12610126" ]

[ "Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells.", "Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule...

[ 1999, 2003 ]

2

[]

0

null

[ "Amniota" ]

[ 350 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 6, 2 ]

3

true

Domain

Signaling lymphocytic activation molecule, N-terminal

Sig_lymph_act_molc_N

1

IPR010408

10,408

Haemagglutinin-esterase glycoprotein, infectious salmon anaemia virus-type

Hemagglutn-estrase_ISAV-type

Family

865

false

This entry represents the haemagglutinin-esterase fusion glycoprotein (HEF) found specifically in infectious anaemia virus (ISAV), an orthomyxovirus-type virus that is an important fish pathogen in marine aquaculture [ , ]. Other viruses, such as influenza C virus, coronaviruses and toroviruses, also contain surface HE...

[]

0

[ "PFAM" ]

[ "PF06215" ]

[ "ISAV_HA" ]

[ 865 ]

1

[]

0

[ "5t96", "5t9y" ]

2

[ "PUB00012292", "PUB00033181", "PUB00033182" ]

[ "11714961", "14990724", "15824888" ]

[ "Antigenic variation among isolates of infectious salmon anaemia virus correlates with genetic variation of the viral haemagglutinin gene.", "Infectious salmon anemia virus specifically binds to and hydrolyzes 4-O-acetylated sialic acids.", "Expression, antigenicity and studies on cell receptor binding of the h...

[ 2001, 2004, 2005 ]

3

[]

0

null

[ "Viruses" ]

[ 865 ]

1

[]

0

true

Family

Haemagglutinin-esterase glycoprotein, infectious salmon anaemia virus-type

Hemagglutn-estrase_ISAV-type

1

IPR010409

10,409

GAGA-binding transcriptional activator

GAGA-bd_tscrpt_act

Family

3,171

false

This family includes GAGA-binding protein protein (gbp) from Soybean that binds to GAGA element dinucleotide repeat DNA [ ]. It seems likely that the region which defines this family mediates DNA binding. This putative domain contains several conserved cysteines and a histidine suggesting this may be a zinc-binding DNA...

[]

0

[ "PFAM", "PANTHER", "SMART" ]

[ "PF06217", "PTHR31421", "SM01226" ]

[ "GAGA_bind", "", "GAGA_bind" ]

[ 3169, 3055, 3098 ]

3

[]

0

[]

0

[ "PUB00013455" ]

[ "12177492" ]

[ "Identification of a soybean protein that interacts with GAGA element dinucleotide repeat DNA." ]

[ 2002 ]

1

[]

0

null

[ "Betaproteobacteria", "Eukaryota" ]

[ 2, 3169 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 30, 8, 12 ]

3

true

Family

GAGA-binding transcriptional activator

GAGA-bd_tscrpt_act

1

IPR010411

10,411

Phage tail assembly chaperone Gp13-like

TAC_Gp13-like

Family

631

false

Tail assembly chaperones (TACs) are required for the morphogenesis of all long-tailed phages. Gp13, a TAC from bacteriophage HK97, is required for tail tube assembly and is thought to be a TAC. The gp13 monomer comprises a single domain consisting of a small three-stranded twisted β-sheet connected to a helical bundle....

[]

0

[ "PFAM" ]

[ "PF06222" ]

[ "Phage_TAC_1" ]

[ 631 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "2ob9" ]

1

[ "PUB00075454" ]

[ "23542344" ]

[ "A conserved spiral structure for highly diverged phage tail assembly chaperones." ]

[ 2013 ]

1

[]

0

null

[ "Anopheles maculatus", "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 1, 580, 41, 9 ]

4

[]

0

true

Family

Phage tail assembly chaperone Gp13-like

TAC_Gp13-like

4

IPR010412

10,412

Protein of unknown function DUF1007

DUF1007

Family

3,903

false

This is a family of conserved bacterial proteins with unknown function.

[]

0

[ "PFAM" ]

[ "PF06226" ]

[ "DUF1007" ]

[ 3903 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR016537" ]

0

1

0

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3875, 4, 24 ]

3

[]

0

true

Family

Protein of unknown function DUF1007

DUF1007

6

IPR010413

10,413

Intracellular heme transport protein HutX-like

HutX-like

Family

1,932

false

This entry represents the homologues of intracellular heme transport protein HutX. HutX is a member of the conserved heme utilization operon from pathogenic E. coli, and includes ChuS, HutX, HuvX, HugX, and ShuX in proteobacteria, among others. It forms a dimer which displays a very similar fold and organization to the...

[]

0

[ "PFAM", "PIRSF", "NCBIFAM", "CDD" ]

[ "PF06228", "PIRSF030840", "TIGR04108", "cd16829" ]

[ "ChuX_HutX", "DUF1008", "HutX", "ChuX_HutX-like" ]

[ 1932, 1248, 1423, 1371 ]

4

[ "GP" ]

[ "GenProp0961" ]

[ "GP:GenProp0961" ]

1

[ "2hqv", "2ovi", "2ph0", "3fm2", "5exv", "6u9j" ]

6

[ "PUB00037855", "PUB00041480", "PUB00048554", "PUB00092780", "PUB00092781" ]

[ "16275907", "17322535", "19319934", "25664785", "26807477" ]

[ "Identification of an Escherichia coli O157:H7 heme oxygenase with tandem functional repeats.", "Crystal structure of AGR_C_4470p from Agrobacterium tumefaciens.", "Structure and heme binding properties of Escherichia coli O157:H7 ChuX.", "Expression, purification and preliminary crystallographic analysis of ...

[ 2005, 2007, 2009, 2015, 2016 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1893, 26, 13 ]

3

[]

0

true

Family

Intracellular heme transport protein HutX-like

HutX-like

3

IPR010414

10,414

Protein FRG1

FRG1

Family

4,347

false

This entry represents Frg1 (FSHD region gene 1), a protein that is considered to be a candidate for facioscapulohumeral muscular dystrophy (FSHD). FSHD is a dominant neuromuscular disorder caused by deletions in a number of tandem repeat units (called D4Z4) located on chromosome 4q35. D4Z4 contains a transcriptional si...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06229", "PTHR12928" ]

[ "FRG1", "" ]

[ 4249, 4145 ]

2

[]

0

[ "2yug", "6zym", "7a5p", "7zoh", "7zoi", "7zon", "7zoo", "7zop", "8i0w" ]

9

[ "PUB00012295", "PUB00035977", "PUB00035978", "PUB00081392" ]

[ "9714712", "16341202", "17103222", "23720823" ]

[ "FRG1, a gene in the FSH muscular dystrophy region on human chromosome 4q35, is highly conserved in vertebrates and invertebrates.", "Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1.", "FRG1P-mediated aggregation of proteins involved in pre-mRNA processing.", "FSHD muscular dystrophy region...

[ 1998, 2006, 2007, 2013 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Methanolobus vulcani", "unclassified dsDNA viruses" ]

[ 75, 4189, 1, 82 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1, 8, 3, 1, 6, 1 ]

8

true

Family

Protein FRG1

FRG1

3

IPR010415

10,415

LpxI, C-terminal

LpxI_C

Domain

3,537

false

This entry represents the catalytic C-terminal domain of the LpxI enzyme that is involved in biosynthesis of lipid A. LpxI hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to form 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the beta-P atom [ ].

[]

0

[ "PFAM" ]

[ "PF06230" ]

[ "LpxI_C" ]

[ 3537 ]

1

[ "GP" ]

[ "GenProp0204" ]

[ "GP:GenProp0204" ]

1

[ "4ggm", "4j6e" ]

2

[ "PUB00086024" ]

[ "20608695" ]

[ "An alternative route for UDP-diacylglucosamine hydrolysis in bacterial lipid A biosynthesis." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3465, 6, 66 ]

3

[]

0

true

Domain

LpxI, C-terminal

LpxI_C

2

IPR010416

10,416

Protein of unknown function DUF1010

DUF1010

Family

289

false

This is a family of plasmid encoded proteins with unknown function.

[]

0

[ "PFAM" ]

[ "PF06231" ]

[ "DUF1010" ]

[ 289 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "plasmids" ]

[ 286, 3 ]

2

[]

0

true

Family

Protein of unknown function DUF1010

DUF1010

7

IPR010418

10,418

ECSIT

Family

1,543

false

Activation of NF-kappaB as a consequence of signalling through the Toll and IL-1 receptors is a major element of innate immune responses. ECSIT (Evolutionarily conserved signaling intermediate in Toll pathway) plays an important role in signalling to NF-kappaB, functioning as an adapter protein of the Toll-like and IL-...

[]

0

[ "PANTHER" ]

[ "PTHR13113" ]

[ "" ]

[ 1543 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-166058", "R-BTA-6799198", "R-BTA-975138", "R-BTA-975871", "R-DME-6799198", "R-HSA-166058", "R-HSA-6799198", "R-HSA-975138", "R-HSA-975871", "R-MMU-166058", "R-MMU-6799198", "R-MMU-975138", "R-MMU-975871", "R-RNO-166058", "R-RNO-6799198", "R-RNO-975138", "R-RNO-975871", "R-XT...

[ "REACTOME:R-BTA-166058", "REACTOME:R-BTA-6799198", "REACTOME:R-BTA-975138", "REACTOME:R-BTA-975871", "REACTOME:R-DME-6799198", "REACTOME:R-HSA-166058", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-975138", "REACTOME:R-HSA-975871", "REACTOME:R-MMU-166058", "REACTOME:R-MMU-6799198", "REACTOME:R-MMU...

21

[ "8phe" ]

1

[ "PUB00012299", "PUB00100985" ]

[ "10465784", "32320651" ]

[ "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.", "Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I." ]

[ 1999, 2020 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1543 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 2, 8, 3, 4 ]

6

true

Family

ECSIT

9

IPR010419

10,419

Carbon monoxide dehydrogenase subunit G

CO_DH_gsu

Family

9,317

false

The CO dehydrogenase structural genes coxMSL are flanked by nine accessory genes arranged as the cox gene cluster. The cox genes are specifically and coordinately transcribed under chemolithoautotrophic conditions in the presence of CO as carbon and energy source [ ].

[]

0

[ "PFAM", "PANTHER", "CDD" ]

[ "PF06240", "PTHR38588", "cd05018" ]

[ "COXG", "", "CoxG" ]

[ 8885, 8063, 4291 ]

3

[]

0

[ "2ns9", "2pcs", "8uds" ]

3

[ "PUB00011525" ]

[ "10433972" ]

[ "Sequence analysis, characterization and CO-specific transcription of the cox gene cluster on the megaplasmid pHCG3 of Oligotropha carboxidovorans." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 386, 8697, 16, 218 ]

4

[]

0

true

Family

Carbon monoxide dehydrogenase subunit G

CO_DH_gsu

5

IPR010420

10,420

CASTOR/POLLUX/SYM8 ion channel, conserved domain

CASTOR/POLLUX/SYM8_dom

Domain

4,116

false

This entry represents a short region in the middle of proteins that belong to the CASTOR/POLLUX/SYM8 family of ion channels, which are found in plants. They have been implicated in modulating the nuclear membrane envelope potential [ ]. Proteins containing this domain also include uncharacterised bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF06241" ]

[ "Castor_Poll_mid" ]

[ 4116 ]

1

[]

0

[ "6o6j", "6o7a", "6o7c", "7vm8" ]

4

[ "PUB00053904" ]

[ "19106374" ]

[ "Lotus japonicus CASTOR and POLLUX are ion channels essential for perinuclear calcium spiking in legume root endosymbiosis." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1089, 2973, 54 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 10, 22 ]

3

true

Domain

CASTOR/POLLUX/SYM8 ion channel, conserved domain

CASTOR/POLLUX/SYM8_dom

8

IPR010421

10,421

Transcriptional cell cycle regulator TrcR

TrcR

Family

2,985

false

This family represents a transcriptional cell cycle regulator (TrcR) found in Proteobacteria, mainly Alphaproteobacteria. TrcR associates with promoters and coding sequences in vivo in a rifampicin-dependent manner and interacts physically and genetically with RNA polymerase, resulting in the integration of cell cycle ...

[]

0

[ "PFAM" ]

[ "PF06242" ]

[ "TrcR" ]

[ 2985 ]

1

[]

0

[]

0

[ "PUB00098048" ]

[ "33602809" ]

[ "The DUF1013 protein TrcR tracks with RNA polymerase to control the bacterial cell cycle and protect against antibiotics." ]

[ 2021 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2931, 12, 42 ]

3

[]

0

true

Family

Transcriptional cell cycle regulator TrcR

TrcR

8

IPR010422

10,422

Coiled-coil domain-containing protein 124/Oxs1

Ccdc124/Oxs1

Family

4,449

false

This entry includes coiled-coil domain-containing protein 124 (Ccdc124) from animals and Oxs1 from fission yeasts. Ccdc124 is a centrosome and midbody protein involved in cytokinesis [ ]. Oxs1 (SPBC29A10.12) is part of the Pap1-Oxs1 complex that regulates transcription when cells are exposed to diamide or Cd that cause...

[]

0

[ "PANTHER" ]

[ "PTHR21680" ]

[ "" ]

[ 4449 ]

1

[]

0

[ "6z6l", "6zm7", "6zme", "8k2c", "8xsy" ]

5

[ "PUB00073830", "PUB00091062" ]

[ "23894443", "27664222" ]

[ "Coiled-coil domain containing protein 124 is a novel centrosome and midbody protein that interacts with the Ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis.", "A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe." ]

[ 2013, 2017 ]

2

[]

0

null

[ "Eukaryota", "viral metagenome" ]

[ 4448, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 5, 2, 1, 1, 2, 1, 2, 5, 3, 1, 3 ]

11

true

Family

Coiled-coil domain-containing protein 124/Oxs1

Ccdc124/Oxs1

8

IPR010423

10,423

Ookinete surface antigen, EGF domain

Pvs25/Psv28_EGF

Domain

457

false

Pvs25 and Pvs28 are expressed on the surface of ookinetes from several species of Plasmodium. These proteins are potential candidates for vaccine and induce antibodies that block the infectivity of Plasmodium vivax in immunised animals [ ]. The structure of these protein shows they are composed of four EGF domains [ ].

[ "GO:0009986", "GO:0016020" ]

[ "cell surface", "membrane" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF06247" ]

[ "Plasmod_Pvs28" ]

[ 457 ]

1

[]

0

[ "1z1y", "1z27", "1z3g", "6azz", "6b08", "6b0a", "6b0e", "6b0g", "6b0h", "6phb", "6phc", "6phd", "6phf", "7txw", "8e1z", "8ezk", "8ezl", "8ezm" ]

18

[ "PUB00012301", "PUB00038712" ]

[ "11738740", "16327807" ]

[ "Antibodies to Plasmodium vivax transmission-blocking vaccine candidate antigens Pvs25 and Pvs28 do not show synergism.", "The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms." ]

[ 2001, 2006 ]

2

[]

0

null

[ "Eukaryota" ]

[ 457 ]

1

[ "Homo sapiens" ]

[ 1 ]

1

true

Domain

Ookinete surface antigen, EGF domain

Pvs25/Psv28_EGF

6

IPR010424

10,424

Acetate kinase EutQ

EutQ

Family

4,232

false

The eut operon of Salmonella typhimurium encodes proteins involved in ethanolamine degradation and is essential during anoxic growth on ethanolamine and tetrathionate [ , ]. EutQ is an acetate kinase necessary to drive flux through the pathway under physiological conditions, preventing a buildup of acetaldehyde. The AT...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06249", "PTHR36169" ]

[ "EutQ", "" ]

[ 3428, 3470 ]

2

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.2.1", "GenProp0292", "GenProp1762", "PWY-5482", "PWY-5485", "PWY-5497", "PWY-8015", "PWY-8086", "PWY-8303", "PWY-8377" ]

[ "EC:2.7.2.1", "GP:GenProp0292", "GP:GenProp1762", "METACYC:PWY-5482", "METACYC:PWY-5485", "METACYC:PWY-5497", "METACYC:PWY-8015", "METACYC:PWY-8086", "METACYC:PWY-8303", "METACYC:PWY-8377" ]

10

[ "2pyt", "3lwc", "4axo" ]

3

[ "PUB00009955", "PUB00063996", "PUB00096913" ]

[ "10464203", "23144756", "26448059" ]

[ "The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins.", "Structural insight into the Clostridium difficile ethanolamine utilisation microcompartment.", "The EutQ and EutP proteins are novel acetate kinases involved in ethanolamine catabolism: phy...

[ 1999, 2012, 2016 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 2553, 1622, 4, 53 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Acetate kinase EutQ

EutQ

9

IPR010425

10,425

Capsule biosynthesis GfcC-like, C-terminal

Caps_synth_GfcC-like_C

Domain

2,256

false

Many bacteria are covered in a layer of surface-associated polysaccharide called the capsule. These capsules can be divided into four groups depending upon the organisation of genes responsible for capsule assembly, the assembly pathway and regulation [ ]. This family plays a role in group 4 capsule biosynthesis [ ]. T...

[]

0

[ "PFAM" ]

[ "PF06251" ]

[ "Caps_syn_GfcC_C" ]

[ 2256 ]

1

[]

0

[ "3p42" ]

1

[ "PUB00044948", "PUB00062058", "PUB00066719", "PUB00099551" ]

[ "17250770", "10200953", "16030220", "21449614" ]

[ "A novel superfamily containing the beta-grasp fold involved in binding diverse soluble ligands.", "Structure, assembly and regulation of expression of capsules in Escherichia coli.", "Identification of an Escherichia coli operon required for formation of the O-antigen capsule.", "The crystal structure of Esc...

[ 2007, 1999, 2005, 2011 ]

4

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 2243, 4, 9 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Capsule biosynthesis GfcC-like, C-terminal

Caps_synth_GfcC-like_C

4

IPR010426

10,426

Trimethylamine methyltransferase

MTTB_MeTrfase

Family

5,647

false

This family consists of several trimethylamine methyltransferase (MTTB) proteins. This enzyme, which catalyses the transfer of a methyl group from trimethylamine to a trimethylamine-specific corrinoid protein (MttC), is involved in methanogenesis from trimethylamine [ ]. This family also includes MtgB, a glycine betain...

[ "GO:0008168", "GO:0015948" ]

[ "methyltransferase activity", "methanogenesis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF" ]

[ "PF06253", "PIRSF037567" ]

[ "MTTB", "MTTB_MeTrfase" ]

[ 5647, 3639 ]

2

[ "EC", "METACYC" ]

[ "2.1.1.250", "PWY-5250" ]

[ "EC:2.1.1.250", "METACYC:PWY-5250" ]

2

[ "2qne", "4yyc", "7xcl", "7xcm", "7xcn" ]

5

[ "PUB00017766", "PUB00086416", "PUB00103671", "PUB00103672" ]

[ "10762254", "25313086", "31341018", "32571881" ]

[ "The trimethylamine methyltransferase gene and multiple dimethylamine methyltransferase genes of Methanosarcina barkeri contain in-frame and read-through amber codons.", "A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase.", "MtpB, a ...

[ 2000, 2014, 2019, 2020 ]

4

[]

[ "IPR012740" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 168, 4786, 4, 689 ]

4

[]

0

true

Family

Trimethylamine methyltransferase

MTTB_MeTrfase

7

IPR010427

10,427

Domain of unknown function DUF1023

DUF1023

Domain

6,607

false

This entry represents a domain found in uncharacterised proteins mainly from Actinobacteria. It covers the full length of the protein in some sequences such as MT0992 and is found associated with in others like MT2140 from Mycobacterium tuberculosis. Computational analysis suggests that they may belong to the α-β hydro...

[]

0

[ "PFAM" ]

[ "PF06259" ]

[ "Abhydrolase_8" ]

[ 6607 ]

1

[]

0

[]

0

[ "PUB00033394" ]

[ "15688435" ]

[ "Protein domain of unknown function DUF1023 is an alpha/beta hydrolase." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6578, 16, 13 ]

3

[]

0

true

Domain

Domain of unknown function DUF1023

DUF1023

4

IPR010428

10,428

Zincin-like metallopeptidase

Zincin_1

Family

11,028

false

This family of proteins has a conserved HEXXH motif, suggesting they are putative peptidases of zincin fold [ ]. The structure of this family is a minimal version of the metalloprotease fold ( ).

[]

0

[ "PFAM" ]

[ "PF06262" ]

[ "Zincin_1" ]

[ 11028 ]

1

[]

0

[ "2ejq", "3e11" ]

2

[ "PUB00075429" ]

[ "23671590" ]

[ "CLCAs - a family of metalloproteases of intriguing phylogenetic distribution and with cases of substituted catalytic sites." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Candidatus Methanophaga sp. ANME-1 ERB7", "Eukaryota", "unclassified sequences" ]

[ 10913, 1, 5, 109 ]

4

[]

0

true

Family

Zincin-like metallopeptidase

Zincin_1

6

IPR010430

10,430

Protein of unknown function DUF1028

DUF1028

Family

5,798

false

This is a family of bacterial and archaeal proteins with unknown function.

[]

0

[ "PFAM" ]

[ "PF06267" ]

[ "DUF1028" ]

[ 5798 ]

1

[]

0

[ "2imh" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 510, 5113, 14, 161 ]

4

[]

0

true

Family

Protein of unknown function DUF1028

DUF1028

8

IPR010431

10,431

Fascin

Family

5,530

false

This entry represents fascin (FSCN) and its homologues, including FSCN1/2/3 from mammals and protein singed from fruit flies. Fascin is a globular actin cross-linking protein, which functions in forming parallel actin bundles in cell protrusions that are key specialisations of the plasma membrane for environmental guid...

[ "GO:0051015", "GO:0007015" ]

[ "actin filament binding", "actin filament organization" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER" ]

[ "PTHR10551" ]

[ "" ]

[ 5530 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6785807", "R-HSA-9662360", "R-HSA-9662361" ]

[ "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-9662360", "REACTOME:R-HSA-9662361" ]

3

[ "1dfc", "3llp", "3p53", "4gov", "4goy", "4gp0", "4gp3", "6b0t", "6i0z", "6i10", "6i11", "6i12", "6i13", "6i14", "6i15", "6i16", "6i17", "6i18", "7zau", "7zoi", "8vo5", "8vo6", "8vo7", "8vo8", "8vo9", "8voa", "9fn6", "9gs6", "9gxi" ]

29

[ "PUB00071711" ]

[ "16002322" ]

[ "Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker?" ]

[ 2005 ]

1

[]

[ "IPR024703" ]

0

1

0

[ "Bacteria", "Eukaryota", "Pandoravirus", "metagenomes" ]

[ 341, 5176, 10, 3 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 3, 7, 5, 15, 10, 13 ]

7

true

Family

Fascin

8

IPR010432

10,432

RDD

Domain

40,849

false

This domain contains three highly conserved amino acids: one arginine and two aspartates, hence the name of RDD domain. This region contains two predicted transmembrane regions. The arginine occurs at the N terminus of the first helix and the first aspartate occurs in the middle of this helix. In Halobacillus andaensis...

[]

0

[ "PFAM" ]

[ "PF06271" ]

[ "RDD" ]

[ 40849 ]

1

[]

0

[]

0

[ "PUB00092688" ]

[ "29922240" ]

[ "Characterization of a Functionally Unknown Arginine-Aspartate-Aspartate Family Protein From Halobacillus andaensis and Functional Analysis of Its Conserved Arginine/Aspartate Residues." ]

[ 2018 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 534, 38119, 1663, 533 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 2, 2, 2 ]

6

true

Domain

RDD

3

IPR010433

10,433

Plant specific eukaryotic initiation factor 4B

EIF-4B_pln

Family

2,890

false

This family consists of several plant specific eukaryotic initiation factor 4B proteins [ ].

[ "GO:0003743" ]

[ "translation initiation factor activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06273", "PTHR32091" ]

[ "eIF-4B", "" ]

[ 2129, 2674 ]

2

[]

0

[]

0

[ "PUB00019501" ]

[ "10600500" ]

[ "Eukaryotic initiation factor 4B from wheat and Arabidopsis thaliana is a member of a multigene family." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2890 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 16, 17, 51 ]

3

true

Family

Plant specific eukaryotic initiation factor 4B

EIF-4B_pln

4

IPR010434

10,434

Protein of unknown function DUF1033

DUF1033

Family

1,083

false

This family consists of several hypothetical bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF06279" ]

[ "DUF1033" ]

[ 1083 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Stephanstirmvirinae", "metagenomes" ]

[ 1076, 3, 4 ]

3

[]

0

true

Family

Protein of unknown function DUF1033

DUF1033

2

IPR010435

10,435

C5a peptidase/Subtilisin-like protease SBT2-like, Fn3-like domain

C5a/SBT2-like_Fn3

Domain

7,130

false

This is a Fn3-like domain found as the first of three on streptococcal C5a peptidase (SCP), a subtilisin-like, highly specific protease and adhesin/invasin that acts as an essential GAS virulence factor for the rapid dissemination of bacteria in soft tissues [ , , ]. This domain is also found at the C-terminal of subti...

[ "GO:0004252", "GO:0005618", "GO:0016020" ]

[ "serine-type endopeptidase activity", "cell wall", "membrane" ]

[ "molecular_function", "cellular_component", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06280" ]

[ "fn3_5" ]

[ 7130 ]

1

[ "EC" ]

[ "3.4.21" ]

[ "EC:3.4.21" ]

1

[ "1xf1", "3eif", "5xxz", "5xya", "5xyr", "6vjb", "7bj3", "7edd", "7yzx", "8bty" ]

10

[ "PUB00046871", "PUB00154367", "PUB00154368" ]

[ "16344483", "30049896", "32257048" ]

[ "Structure of the streptococcal cell wall C5a peptidase.", "Structure of ScpC, a virulence protease from Streptococcus pyogenes, reveals the functional domains and maturation mechanism.", "Structure, dynamics and immunogenicity of a catalytically inactive CXC chemokine-degrading protease SpyCEP fr...

[ 2005, 2018, 2020 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 7, 2392, 4730, 1 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 1, 3, 1 ]

4

true

Domain

C5a peptidase/Subtilisin-like protease SBT2-like, Fn3-like domain

C5a/SBT2-like_Fn3

3

IPR010436

10,436

Herpesvirus UL84

Herpes_UL84

Family

100

false

This family consists of several Cytomegalovirus UL84 proteins. The open reading frame UL84 of human cytomegalovirus encodes a multifunctional regulatory protein which is required for viral DNA replication and binds with high affinity to the immediate-early transactivator IE2-p86 [ ]. This protein interacts with DNA seq...

[]

0

[ "PFAM" ]

[ "PF06284" ]

[ "Cytomega_UL84" ]

[ 100 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[]

0

[ "PUB00012307", "PUB00100070" ]

[ "12610148", "19631360" ]

[ "A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.", "Interaction of HCMV UL84 with C/EBPalpha transcription factor binding sites within oriLyt is essential for lytic DNA replication." ]

[ 2003, 2009 ]

2

[]

0

null

[ "Betaherpesvirinae" ]

[ 100 ]

1

[]

0

true

Family

Herpesvirus UL84

Herpes_UL84

5

IPR010437

10,437

Type III secretion system SsaH/EsaH

T3SS_SsaH/EsaH

Family

635

false

This family describes a small protein, always smaller than 100 amino acids, encoded in pathogenicity islands for bacterial type III secretion systems in various strains of Yersinia, Salmonella, and enteropathogenic Escherichia coli, as well as Chromobacterium violaceum and Citrobacter rodentium, which are part of the E...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF06287", "TIGR02498" ]

[ "DUF1039", "type_III_ssaH" ]

[ 635, 578 ]

2

[]

0

[ "7y6b", "7y6c" ]

2

[ "PUB00106879", "PUB00106881" ]

[ "35861543", "30651351" ]

[ "Secreted in a Type III Secretion System-Dependent Manner, EsaH and EscE Are the Cochaperones of the T3SS Needle Protein EsaG of Edwardsiella piscicida.", "Chaperone-mediated secretion switching from early to middle substrates in the type III secretion system encoded by Salmonella pathogenicity island 2." ...

[ 2022, 2019 ]

2

[]

0

null

[ "Bacteria" ]

[ 635 ]

1

[]

0

true

Family

Type III secretion system SsaH/EsaH

T3SS_SsaH/EsaH

4

IPR010438

10,438

Bor

Lambda_Bor

Family

1,126

false

This family consists of several Bacteriophage lambda Bor and Escherichia coli Iss proteins. Expression of bor significantly increases the survival of the E. coli host cell in animal serum. This property is a well known bacterial virulence determinant. Indeed, bor and its adjacent sequences are highly homologous to the ...

[]

0

[ "PFAM" ]

[ "PF06291" ]

[ "Lambda_Bor" ]

[ 1126 ]

1

[]

0

[]

0

[ "PUB00012311", "PUB00056866" ]

[ "2144037", "17309614" ]

[ "A bacterial virulence determinant encoded by lysogenic coliphage lambda.", "Detection of Iss and Bor on the surface of Escherichia coli." ]

[ 1990, 2007 ]

2

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 1030, 59, 16, 21 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bor

Lambda_Bor

5

IPR010439

10,439

MUN domain

MUN_dom

Domain

19,775

false

This entry corresponds to the MUN domain [ ] found in Munc13 proteins. These constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholip...

[]

0

[ "PFAM", "SMART" ]

[ "PF06292", "SM01145" ]

[ "MUN", "DUF1041" ]

[ 19773, 14229 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-181429", "R-CEL-181430", "R-CEL-210500", "R-CEL-212676", "R-CEL-264642", "R-HSA-181429", "R-HSA-181430", "R-HSA-210500", "R-HSA-212676", "R-HSA-264642", "R-HSA-6798695", "R-MMU-181429", "R-MMU-181430", "R-MMU-210500", "R-MMU-212676", "R-MMU-264642", "R-MMU-6798695", "R-RNO-1...

[ "REACTOME:R-CEL-181429", "REACTOME:R-CEL-181430", "REACTOME:R-CEL-210500", "REACTOME:R-CEL-212676", "REACTOME:R-CEL-264642", "REACTOME:R-HSA-181429", "REACTOME:R-HSA-181430", "REACTOME:R-HSA-210500", "REACTOME:R-HSA-212676", "REACTOME:R-HSA-264642", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-18...

23

[ "3swh", "4y21", "5ue8", "5uf7", "6a30", "6a68", "7t7c", "7t7r", "7t7v", "7t7x", "7t81", "9la9" ]

12

[ "PUB00097712" ]

[ "28177287" ]

[ "Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN." ]

[ 2017 ]

1

[]

0

null

[ "Eukaryota" ]

[ 19775 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 20, 141, 13, 43, 28, 1, 53, 1 ]

8

true

Domain

MUN domain

MUN_dom

2

IPR010441

10,441

CH-like domain in sperm protein

CH_2

Domain

4,772

false

This entry represents a domain known as Spef, which is a region of sperm flagellar proteins. It probably exerts a role in spermatogenesis in that the protein is expressed predominantly in adult tissue. It is present in the tails of developing and epididymal sperm internal to the fibrous sheath and around the dense oute...

[]

0

[ "PFAM" ]

[ "PF06294" ]

[ "CH_2" ]

[ 4772 ]

1

[]

0

[ "2ee7", "7n61", "7n6g", "7som", "7sqc", "9ijj", "9ntm", "9nw3" ]

8

[ "PUB00044949", "PUB00044950" ]

[ "15979255", "16549801" ]

[ "Spef1, a conserved novel testis protein found in mouse sperm flagella.", "An intronic insertion in KPL2 results in aberrant splicing and causes the immotile short-tail sperm defect in the pig." ]

[ 2005, 2006 ]

2

[ "IPR001715" ]

[]

1

0

1

[ "Eukaryota", "bird metagenome" ]

[ 4771, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 8, 11, 9 ]

5

true

Domain

CH-like domain in sperm protein

CH_2

2

IPR010443

10,443

Restriction endonuclease, type II, Tsp45I

Restrct_endonuc_II_Tsp45I

Family

162

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06300", "PIRSF020467" ]

[ "Tsp45I", "Restrict_endonuc_II_Tsp45I" ]

[ 162, 37 ]

2

[]

0

[]

0

[ "PUB00020501", "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "9427549", "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "The Tsp45I restriction-modification system is plasmid-borne within its thermophilic host.", "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restri...

[ 1997, 2005, 2003, 2002, 2001, 2004, 2003 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Potamilus streckersoni", "metagenomes" ]

[ 6, 146, 1, 9 ]

4

[]

0

true

Family

Restriction endonuclease, type II, Tsp45I

Restrct_endonuc_II_Tsp45I

7

IPR010444

10,444

Bacteriophage lambda Kil

Phage_lambda_Kil

Family

471

false

This family consists of several Bacteriophage lambda Kil protein like sequences and prophages mainly found in proteobacteria. A cessation of division, followed by one or two fairly synchronous cell divisions in Escherichia coli is due to two genetically separable events: a temporary block of cell division and, at the s...

[]

0

[ "PFAM" ]

[ "PF06301" ]

[ "Lambda_Kil" ]

[ 471 ]

1

[]

0

[]

0

[ "PUB00012314", "PUB00043652", "PUB00043653" ]

[ "11470529", "12441108", "8460474" ]

[ "Cell toxicity caused by products of the p(L) operon of bacteriophage lambda.", "E.coli cell-cycle regulation by bacteriophage lambda.", "Lambda kil-mediated lysis requires the phage context." ]

[ 2001, 2002, 1993 ]

3

[]

0

null

[ "Bacteria", "Viruses" ]

[ 377, 94 ]

2

[]

0

true

Family

Bacteriophage lambda Kil

Phage_lambda_Kil

4

IPR010445

10,445

Lipopolysaccharide assembly protein A domain

LapA_dom

Domain

12,540

false

This entry represents a domain found in lipopolysaccharide assembly protein A (LapA). LabA and LapB function together in the assembly of lipopolysaccharide (LPS) [ ]. This domain is also found in some uncharacterised proteins, such as Rv3760 from Mycobacterium tuberculosis.

[ "GO:0005886" ]

[ "plasma membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF06305" ]

[ "LapA_dom" ]

[ 12540 ]

1

[]

0

[]

0

[ "PUB00074284" ]

[ "24722986" ]

[ "Assembly of lipopolysaccharide in Escherichia coli requires the essential LapB heat shock protein." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12388, 5, 147 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Lipopolysaccharide assembly protein A domain

LapA_dom

9

IPR010446

10,446

Beta-1,4-N-acetylgalactosaminyltransferase

GalNAc_Trfase_b

Family

317

false

This family consists of several beta-1,4-N-acetylgalactosaminyltransferase proteins [ ].

[]

0

[ "PFAM" ]

[ "PF06306" ]

[ "CgtA" ]

[ 317 ]

1

[]

0

[]

0

[ "PUB00012315" ]

[ "10660542" ]

[ "Biosynthesis of ganglioside mimics in Campylobacter jejuni OH4384. Identification of the glycosyltransferase genes, enzymatic synthesis of model compounds, and characterization of nanomole amounts by 600-mhz (1)h and (13)c NMR analysis." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Parabasalia" ]

[ 313, 4 ]

2

[]

0

true

Family

Beta-1,4-N-acetylgalactosaminyltransferase

GalNAc_Trfase_b

6

IPR010447

10,447

Herpesvirus IR6

Herpes_IR6

Family

70

false

This family consists of several Herpesvirus IR6 proteins. The equine herpesvirus 1 (EHV-1) IR6 protein forms typical rod-like structures in infected cells, influences virus growth at elevated temperatures, and determines the virulence of EHV-1 Rac strains [ ].

[]

0

[ "PFAM" ]

[ "PF06307" ]

[ "Herpes_IR6" ]

[ 70 ]

1

[]

0

[]

0

[ "PUB00012316" ]

[ "9811716" ]

[ "The equine herpesvirus 1 IR6 protein that colocalizes with nuclear lamins is involved in nucleocapsid egress and migrates from cell to cell independently of virus infection." ]

[ 1998 ]

1

[]

0

null

[ "Varicellovirus" ]

[ 70 ]

1

[]

0

true

Family

Herpesvirus IR6

Herpes_IR6

5

IPR010449

10,449

NUMB domain

Numb_domain

Domain

3,028

false

This entry represents a domain found in the cell-fate determinant Numb, and in related proteins. In Drosophila, two signalling pathways, one mediated by Numb and the other by Notch, play essential but antagonistic roles in enabling the two daughters to adopt different fates after a wide variety of asymmetric cell divis...

[]

0

[ "PFAM" ]

[ "PF06311" ]

[ "NumbF" ]

[ 3028 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2122948", "R-HSA-437239", "R-HSA-5610780", "R-HSA-5632684", "R-HSA-9725554", "R-MMU-437239", "R-MMU-5610780", "R-MMU-5632684", "R-RNO-437239", "R-RNO-5610780", "R-RNO-5632684" ]

[ "REACTOME:R-HSA-2122948", "REACTOME:R-HSA-437239", "REACTOME:R-HSA-5610780", "REACTOME:R-HSA-5632684", "REACTOME:R-HSA-9725554", "REACTOME:R-MMU-437239", "REACTOME:R-MMU-5610780", "REACTOME:R-MMU-5632684", "REACTOME:R-RNO-437239", "REACTOME:R-RNO-5610780", "REACTOME:R-RNO-5632684" ]

11

[ "5yqg" ]

1

[ "PUB00035856", "PUB00035857", "PUB00035858" ]

[ "16508312", "17116748", "16508311" ]

[ "The enigma of the numb-Notch relationship during mammalian embryogenesis.", "High levels of Notch signaling down-regulate Numb and Numblike.", "Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain." ]

[ 2006, 2006, 2006 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3028 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 10, 4, 15 ]

5

true

Domain

NUMB domain

Numb_domain

9

IPR010450

10,450

Neurexophilin

Nxph

Family

3,704

false

Neurexophilins (Nxphs) comprise a family of glycoproteins (Nxph1-4) that exhibit characteristics of secreted, preproprotein-derived molecules [ ]. The structure and characteristics of neurexophilins indicate that they function as neuropeptides that may signal via alpha-neurexins [ ]. Nxph1 plays an instructive role in ...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF038019", "PTHR17103" ]

[ "Neurexophilin", "" ]

[ 2242, 3704 ]

2

[]

0

[ "6pnp", "6pnq" ]

2

[ "PUB00012319", "PUB00077049", "PUB00077050", "PUB00077051" ]

[ "9570794", "25157101", "26041738", "24639499" ]

[ "Neurexophilins form a conserved family of neuropeptide-like glycoproteins.", "Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain.", "Identification of Neurexophilin 3 as a Novel Supportive Factor for Survival of Induced Pluripotent Stem Cell-Derived Dopaminergic Progen...

[ 1998, 2014, 2015, 2014 ]

4

[ "IPR026845" ]

[]

1

0

1

[ "Vertebrata", "bird metagenome" ]

[ 3703, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 13, 8, 13 ]

4

true

Family

Neurexophilin

Nxph

3

IPR010451

10,451

Acetoacetate decarboxylase

Acetoacetate_decarboxylase

Family

7,878

false

Acetoacetate decarboxylase (ADC) is involved in solventogenesis in certain bacteria, which occurs at the end of the exponential growth phase when there is a metabolic switch from classical sugar fermentation with the production of acetate and butyrate to the re-internalisation and oxidation of these acids to acetate an...

[ "GO:0016829" ]

[ "lyase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06314" ]

[ "ADC" ]

[ 7878 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "4.1.1.4", "PWY-6588", "PWY-6876" ]

[ "EC:4.1.1.4", "METACYC:PWY-6588", "METACYC:PWY-6876" ]

3

[ "3bgt", "3bh2", "3bh3", "3c8w", "3cmb", "4jm3", "4jmc", "4jmd", "4jme", "4zbo", "4zbt", "5upb", "6eej" ]

13

[ "PUB00014916", "PUB00014917", "PUB00014918" ]

[ "11824611", "10972834", "12236595" ]

[ "Changes in protein synthesis and identification of proteins specifically induced during solventogenesis in Clostridium acetobutylicum.", "Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia.", "A decarboxylase encoded at the Cochliobolus heterostrophus translocation...

[ 2002, 2000, 2002 ]

3

[]

[ "IPR023653", "IPR031022" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes", "uncultured virus" ]

[ 252, 6002, 1479, 144, 1 ]

5

[]

0

true

Family

Acetoacetate decarboxylase

Acetoacetate_decarboxylase

5

IPR010452

10,452

Isocitrate dehydrogenase kinasephosphatase

Isocitrate_DH_AceK

Family

4,665

false

This family consists of several bacterial isocitrate dehydrogenase kinase/phosphatase (ICDH kinase/phosphatase) proteins. The enzyme has no activating compound but is specific for its substrate. It is a bifunctional enzyme that catalyses the reversible phosphorylation of isocitrate dehydrogenase (IDH, ) on a seryl resi...

[ "GO:0008772", "GO:0016791", "GO:0006006", "GO:0005737" ]

[ "[isocitrate dehydrogenase (NADP+)] kinase activity", "phosphatase activity", "glucose metabolic process", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "HAMAP", "NCBIFAM", "PIRSF", "PANTHER" ]

[ "MF_00747", "NF002804", "PIRSF000719", "PTHR39559" ]

[ "AceK", "PRK02946.1", "AceK", "" ]

[ 4396, 4446, 4383, 4665 ]

4

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.7.11.5", "3.1.3.-", "PWY-4702", "PWY-5491", "PWY-6148", "PWY-6352", "PWY-6365", "PWY-6366", "PWY-6368", "PWY-6456", "PWY-6575", "PWY-6627", "PWY-6664", "PWY-6686", "PWY-6720", "PWY-6724", "PWY-6955", "PWY-6990", "PWY-6991", "PWY-7018", "PWY-7119", "PWY-7321", "PWY-7531...

[ "EC:2.7.11.5", "EC:3.1.3.-", "METACYC:PWY-4702", "METACYC:PWY-5491", "METACYC:PWY-6148", "METACYC:PWY-6352", "METACYC:PWY-6365", "METACYC:PWY-6366", "METACYC:PWY-6368", "METACYC:PWY-6456", "METACYC:PWY-6575", "METACYC:PWY-6627", "METACYC:PWY-6664", "METACYC:PWY-6686", "METACYC:PWY-6720",...

37

[ "3eps", "3lc6", "3lcb", "4p69", "6k5l" ]

5

[ "PUB00043362", "PUB00043363", "PUB00043364" ]

[ "11258918", "11751849", "16415587" ]

[ "The \"catalytic\" triad of isocitrate dehydrogenase kinase/phosphatase from E. coli and its relationship with that found in eukaryotic protein kinases.", "Bacillus subtilis isocitrate dehydrogenase. A substrate analogue for Escherichia coli isocitrate dehydrogenase kinase/phosphatase.", "Control of isocitrate ...

[ 2001, 2002, 2005 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 4616, 9, 40 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Isocitrate dehydrogenase kinasephosphatase

Isocitrate_DH_AceK

8

IPR010453

10,453

RNA polymerase, arenaviral

RNA_pol_arenavir

Family

1,306

false

This family consists of several Arenavirus RNA polymerase proteins ( ) [ ].

[ "GO:0003968", "GO:0019079" ]

[ "RNA-directed RNA polymerase activity", "viral genome replication" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PIRSF" ]

[ "MF_04086", "PF06317", "PIRSF000836" ]

[ "ARENA_L", "Arena_RNA_pol", "L_ArenaV" ]

[ 647, 1306, 717 ]

3

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[ "6klc", "6kld", "6kle", "6klh", "7ckl", "7ckm", "7eju", "7el9", "7ela", "7elb", "7elc", "7och", "7oe3", "7oe7", "7oea", "7oeb", "7ojj", "7ojk", "7ojl", "7ojn", "7vgq", "7vh1", "7vh2", "7vh3", "7x6s", "7x6v", "8xpo" ]

27

[ "PUB00012322" ]

[ "2705303" ]

[ "The primary structure of the lymphocytic choriomeningitis virus L gene encodes a putative RNA polymerase." ]

[ 1989 ]

1

[]

0

null

[ "Riboviria" ]

[ 1306 ]

1

[]

0

true

Family

RNA polymerase, arenaviral

RNA_pol_arenavir

2

IPR010454

10,454

Bacteriophage NinH

Phage_NinH

Family

598

false

This entry includes NinH from Bacteriophage 933W. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

[]

0

[ "PFAM" ]

[ "PF06322" ]

[ "Phage_NinH" ]

[ 598 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses" ]

[ 490, 108 ]

2

[]

0

true

Family

Bacteriophage NinH

Phage_NinH

4

IPR010455

10,455

Bacteriophage 82, GpQ

Phage_82_GpQ

Family

1,391

false

This entry is represented by Bacteriophage 82, GpQ. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of several phage antitermination protein Q and related bacterial sequences. Phage 82 gene Q encodes a phage-specific positive regulator of l...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06323", "PIRSF004417" ]

[ "Phage_antiter_Q", "Anti_term_Q" ]

[ 1391, 731 ]

2

[]

0

[]

0

[ "PUB00012323" ]

[ "3624233" ]

[ "Bacteriophage 82 gene Q and Q protein. Sequence, overproduction, and activity as a transcription antiterminator in vitro." ]

[ 1987 ]

1

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 1376, 13, 2 ]

3

[]

0

true

Family

Bacteriophage 82, GpQ

Phage_82_GpQ

6

IPR010457

10,457

Immunoglobulin C2-set-like, ligand-binding

IgC2-like_lig-bd

Domain

4,297

false

This entry represents a ligand-binding domain that displays similarity to C2-set immunoglobulin domains (antibody constant domain 2) [ ]. The two cysteine residues form a disulphide bridge.

[]

0

[ "PFAM" ]

[ "PF06328" ]

[ "Lep_receptor_Ig" ]

[ 4297 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-1059683", "R-HSA-110056", "R-HSA-112411", "R-HSA-2586552", "R-HSA-449836", "R-HSA-6788467", "R-HSA-8984722", "R-HSA-9020591", "R-HSA-9020956", "R-HSA-9616222", "R-HSA-9674555", "R-HSA-9705462", "R-MMU-1059683", "R-MMU-110056", "R-MMU-112411", "R-MMU-6788467", "R-MMU-8984722", ...

[ "REACTOME:R-HSA-1059683", "REACTOME:R-HSA-110056", "REACTOME:R-HSA-112411", "REACTOME:R-HSA-2586552", "REACTOME:R-HSA-449836", "REACTOME:R-HSA-6788467", "REACTOME:R-HSA-8984722", "REACTOME:R-HSA-9020591", "REACTOME:R-HSA-9020956", "REACTOME:R-HSA-9616222", "REACTOME:R-HSA-9674555", "REACTOME:R...

25

[ "1i1r", "1p9m", "2d9q", "3l5h", "7u7n", "7z0l", "7z3r", "8avb", "8avc", "8avd", "8ave", "8avf", "8avo", "8b7q", "8d6a", "8d74", "8d7r", "8d82", "8d85", "8dh8", "8dh9", "8dha", "8dps", "8dpt", "8dpu", "8odz", "8oe0", "8pb1", "8qy4", "8qy5", "8qy6", "8v29"...

40

[ "PUB00012326" ]

[ "9501088" ]

[ "Crystal structure of a cytokine-binding region of gp130." ]

[ 1998 ]

1

[]

0

null

[ "Bilateria" ]

[ 4297 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 18, 28, 16, 24 ]

4

true

Domain

Immunoglobulin C2-set-like, ligand-binding

IgC2-like_lig-bd

5