prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule Cc1nc(CN2CCOC[C@H]2C2CC2)oc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CN2CCOC[C@H]2C2CCCCC2)oc1C
|
Cc1nc(CN2CCOC[C@H]2C2CC2)oc1C
|
Cc1nc(CN2CCOC[C@H]2C2CCCCC2)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCC1",
"old_substring": "C15CC1"
}
|
Can you make molecule Cc1nc(CN2CCOC[C@H]2C2CC2)oc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CN2CCOC[C@H]2C2SCCCS2)oc1C
|
Cc1nc(CN2CCOC[C@H]2C2CC2)oc1C
|
Cc1nc(CN2CCOC[C@H]2C2SCCCS2)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCCCS1",
"old_substring": "C15CC1"
}
|
Can you make molecule Cc1nc(CN2CCOC[C@H]2C2CC2)oc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CN2CCOC[C@H]2C2SCSCS2)oc1C
|
Cc1nc(CN2CCOC[C@H]2C2CC2)oc1C
|
Cc1nc(CN2CCOC[C@H]2C2SCSCS2)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&SCSCS1",
"old_substring": "C15CC1"
}
|
Can you make molecule Cc1nc(CN2CCOC[C@H]2C2CC2)oc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CN2CCOC[C@H]2C2CCCCCC2)oc1C
|
Cc1nc(CN2CCOC[C@H]2C2CC2)oc1C
|
Cc1nc(CN2CCOC[C@H]2C2CCCCCC2)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CCCCCC1",
"old_substring": "C15CC1"
}
|
Can you make molecule Cc1nc(CN2CCOC[C@H]2C2CC2)oc1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(CN2CCOC[C@H]2C2CSCCSC2)oc1C
|
Cc1nc(CN2CCOC[C@H]2C2CC2)oc1C
|
Cc1nc(CN2CCOC[C@H]2C2CSCCSC2)oc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&CSCCSC1",
"old_substring": "C15CC1"
}
|
Can you make molecule CC(C)(c1ccccc1)[C@H](OC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(c1ccccc1)[C@H](OSC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F
|
CC(C)(c1ccccc1)[C@H](OC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F
|
CC(C)(c1ccccc1)[C@H](OSC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule CC(C)(c1ccccc1)[C@H](OC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)O[C@H](C(F)(F)F)C(C)(C)c1ccccc1)[C@@H]1COC(=O)C1
|
CC(C)(c1ccccc1)[C@H](OC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F
|
CC(C)(CC(=O)O[C@H](C(F)(F)F)C(C)(C)c1ccccc1)[C@@H]1COC(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule CC(C)(c1ccccc1)[C@H](OC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(c1ccccc1)[C@H](OC[S@+]([O-])CCC[C@@H]1COC(=O)C1)C(F)(F)F
|
CC(C)(c1ccccc1)[C@H](OC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F
|
CC(C)(c1ccccc1)[C@H](OC[S@+]([O-])CCC[C@@H]1COC(=O)C1)C(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule CC(C)(c1ccccc1)[C@H](OC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)O[C@H](C(F)(F)F)C(C)(C)c1ccccc1)[C@@H]1COC(=O)C1
|
CC(C)(c1ccccc1)[C@H](OC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F
|
CC(C)(CCC(=O)O[C@H](C(F)(F)F)C(C)(C)c1ccccc1)[C@@H]1COC(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule CC(C)(c1ccccc1)[C@H](OC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@@H](CC(=O)O[C@H](C(F)(F)F)C(C)(C)c1ccccc1)[C@@H]1COC(=O)C1
|
CC(C)(c1ccccc1)[C@H](OC(=O)C[C@@H]1COC(=O)C1)C(F)(F)F
|
C[C@@H](CC(=O)O[C@H](C(F)(F)F)C(C)(C)c1ccccc1)[C@@H]1COC(=O)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C[C@@H]&C",
"old_substring": "C2(=O)C4"
}
|
Can you make molecule CC(=O)CCc1ccc(OCC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)CCc1ccc(OC/C(C)=N\ON2CCO[C@@H]3CCCC[C@H]32)cc1
|
CC(=O)CCc1ccc(OCC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1
|
CC(=O)CCc1ccc(OC/C(C)=N\ON2CCO[C@@H]3CCCC[C@H]32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C5C4=O"
}
|
Can you make molecule CC(=O)CCc1ccc(OCC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(Oc1ccc(CCC(C)=O)cc1)C(=O)CN1CCO[C@@H]2CCCC[C@H]21
|
CC(=O)CCc1ccc(OCC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1
|
CCC(CC)(Oc1ccc(CCC(C)=O)cc1)C(=O)CN1CCO[C@@H]2CCCC[C@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C5C4=O"
}
|
Can you make molecule CC(=O)CCc1ccc(OCC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)CCc1ccc(OSSC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1
|
CC(=O)CCc1ccc(OCC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1
|
CC(=O)CCc1ccc(OSSC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C5C4=O"
}
|
Can you make molecule CC(=O)CCc1ccc(OCC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)(Oc1ccc(CCC(C)=O)cc1)C(=O)CCN1CCO[C@@H]2CCCC[C@H]21
|
CC(=O)CCc1ccc(OCC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1
|
CCC(CC)(Oc1ccc(CCC(C)=O)cc1)C(=O)CCN1CCO[C@@H]2CCCC[C@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C5C4=O"
}
|
Can you make molecule CC(=O)CCc1ccc(OCC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC[C@H](C(=O)Oc1ccc(CCC(C)=O)cc1)C(=O)N1CCO[C@@H]2CCCC[C@H]21
|
CC(=O)CCc1ccc(OCC(=O)N2CCO[C@@H]3CCCC[C@H]32)cc1
|
CC[C@H](C(=O)Oc1ccc(CCC(C)=O)cc1)C(=O)N1CCO[C@@H]2CCCC[C@H]21
| 102
|
{
"fragment_index": 0,
"new_substring": "CC[C@H](C&=O)C&=O",
"old_substring": "C5C4=O"
}
|
Can you make molecule CNC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNSC(=O)Cc1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
|
CNC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
|
CNSC(=O)Cc1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C37=O"
}
|
Can you make molecule CNC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)CCCC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
|
CNC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
|
CNC(=O)CCCC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C37=O"
}
|
Can you make molecule CNC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)CC(C)(C)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
|
CNC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
|
CNC(=O)CC(C)(C)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule CNC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNC(=O)CCC(C)(C)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
|
CNC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
|
CNC(=O)CCC(C)(C)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C37=O"
}
|
Can you make molecule CNC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CNSC(=O)[C@@H](C)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
|
CNC(=O)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
|
CNSC(=O)[C@@H](C)c1ccc(CNC(=O)C(=Cc2ccccc2)NC(C)=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C37=O"
}
|
Can you make molecule COC(=O)[C@@H](N)CC(=O)OC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)OC(=O)C[C@H](N)C(=O)C(=O)C1=CCC1
|
COC(=O)[C@@H](N)CC(=O)OC(C)(C)C
|
CC(C)(C)OC(=O)C[C@H](N)C(=O)C(=O)C1=CCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C1=CCC1",
"old_substring": "CO1"
}
|
Can you make molecule COC(=O)[C@@H](N)CC(=O)OC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)OC(=O)C[C@H](N)C(=O)C(=O)C1=CSCCO1
|
COC(=O)[C@@H](N)CC(=O)OC(C)(C)C
|
CC(C)(C)OC(=O)C[C@H](N)C(=O)C(=O)C1=CSCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C1=CSCCO1",
"old_substring": "CO1"
}
|
Can you make molecule COC(=O)[C@@H](N)CC(=O)OC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)OC(=O)C[C@H](N)C(=O)C(=O)C1=COCCC1
|
COC(=O)[C@@H](N)CC(=O)OC(C)(C)C
|
CC(C)(C)OC(=O)C[C@H](N)C(=O)C(=O)C1=COCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C1=COCCC1",
"old_substring": "CO1"
}
|
Can you make molecule COC(=O)[C@@H](N)CC(=O)OC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)OC(=O)C[C@H](N)C(=O)C(=O)C1=CCCCC1
|
COC(=O)[C@@H](N)CC(=O)OC(C)(C)C
|
CC(C)(C)OC(=O)C[C@H](N)C(=O)C(=O)C1=CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)C1=CCCCC1",
"old_substring": "CO1"
}
|
Can you make molecule COC(=O)[C@@H](N)CC(=O)OC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)OC(=O)C[C@H](N)C(=O)C(=O)CC1=CCCCC1
|
COC(=O)[C@@H](N)CC(=O)OC(C)(C)C
|
CC(C)(C)OC(=O)C[C@H](N)C(=O)C(=O)CC1=CCCCC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC1=CCCCC1",
"old_substring": "CO1"
}
|
Can you make molecule CCC(CC)[C@@H](O)[C@H]1CCc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)[C@@H](C)[C@H]1CCc2ccccc2C1
|
CCC(CC)[C@@H](O)[C@H]1CCc2ccccc2C1
|
CCC(CC)[C@@H](C)[C@H]1CCc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(CC)[C@H]&C",
"old_substring": "CCC(CC)[C@H]3O"
}
|
Can you make molecule CCC(CC)[C@@H](O)[C@H]1CCc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)[C@@H](CO)C[C@H]1CCc2ccccc2C1
|
CCC(CC)[C@@H](O)[C@H]1CCc2ccccc2C1
|
CCC(CC)[C@@H](CO)C[C@H]1CCc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(CC)[C@H](C&)CO",
"old_substring": "CCC(CC)[C@H]3O"
}
|
Can you make molecule CCC(CC)[C@@H](O)[C@H]1CCc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)[C@H](CO)C[C@H]1CCc2ccccc2C1
|
CCC(CC)[C@@H](O)[C@H]1CCc2ccccc2C1
|
CCC(CC)[C@H](CO)C[C@H]1CCc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC(CC)[C@@H](C&)CO",
"old_substring": "CCC(CC)[C@H]3O"
}
|
Can you make molecule CCC(CC)[C@@H](O)[C@H]1CCc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC[C@@H](C)[C@H]1CCc2ccccc2C1
|
CCC(CC)[C@@H](O)[C@H]1CCc2ccccc2C1
|
CCCCC[C@@H](C)[C@H]1CCc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC[C@H]&C",
"old_substring": "CCC(CC)[C@H]3O"
}
|
Can you make molecule CCC(CC)[C@@H](O)[C@H]1CCc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCCC[C@H](O)[C@H]1CCc2ccccc2C1
|
CCC(CC)[C@@H](O)[C@H]1CCc2ccccc2C1
|
CCCCCC[C@H](O)[C@H]1CCc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCCC[C@@H]&O",
"old_substring": "CCC(CC)[C@H]3O"
}
|
Can you make molecule CC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CO)=Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
|
CC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
|
CCC(CO)=Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&CO",
"old_substring": "CC4=O"
}
|
Can you make molecule CC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
|
CC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
|
CCCC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCC&=O",
"old_substring": "CC4=O"
}
|
Can you make molecule CC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)SNc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
|
CC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
|
CC(=O)SNc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CC4=O"
}
|
Can you make molecule CC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCCCC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
|
CC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
|
CCCCC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCCCC&=O",
"old_substring": "CC4=O"
}
|
Can you make molecule CC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(C=O)=Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
|
CC(=O)Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
|
CCC(C=O)=Nc1ccc(S(=O)(=O)N[C@@H]2CC(=O)N(c3ccc(F)cc3)C2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC=&C=O",
"old_substring": "CC4=O"
}
|
Can you make molecule COc1ccc2c(c1)C=C(C(=O)N1C[C@@H]3CC[C@H]1C3)CO2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc2c(c1)C=C(C(=O)[C@@H]1CCCS[C@H]1C)CO2
|
COc1ccc2c(c1)C=C(C(=O)N1C[C@@H]3CC[C@H]1C3)CO2
|
COc1ccc2c(c1)C=C(C(=O)[C@@H]1CCCS[C@H]1C)CO2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCCS[C@H]1C",
"old_substring": "N14C[C@@H]2CC[C@H]1C2"
}
|
Can you make molecule COc1ccc2c(c1)C=C(C(=O)N1C[C@@H]3CC[C@H]1C3)CO2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc2c(c1)C=C(C(=O)[C@H]1CCCC[C@@H]1I)CO2
|
COc1ccc2c(c1)C=C(C(=O)N1C[C@@H]3CC[C@H]1C3)CO2
|
COc1ccc2c(c1)C=C(C(=O)[C@H]1CCCC[C@@H]1I)CO2
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CCCC[C@@H]1I",
"old_substring": "N14C[C@@H]2CC[C@H]1C2"
}
|
Can you make molecule COc1ccc2c(c1)C=C(C(=O)N1C[C@@H]3CC[C@H]1C3)CO2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc2c(c1)C=C(C(=O)N1CC13CCCCC3)CO2
|
COc1ccc2c(c1)C=C(C(=O)N1C[C@@H]3CC[C@H]1C3)CO2
|
COc1ccc2c(c1)C=C(C(=O)N1CC13CCCCC3)CO2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC12CCCCC2",
"old_substring": "N14C[C@@H]2CC[C@H]1C2"
}
|
Can you make molecule COc1ccc2c(c1)C=C(C(=O)N1C[C@@H]3CC[C@H]1C3)CO2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc2c(c1)C=C(C(=O)[C@@H](C#N)CCCCl)CO2
|
COc1ccc2c(c1)C=C(C(=O)N1C[C@@H]3CC[C@H]1C3)CO2
|
COc1ccc2c(c1)C=C(C(=O)[C@@H](C#N)CCCCl)CO2
| 102
|
{
"fragment_index": 0,
"new_substring": "N#C[C@H]&CCCCl",
"old_substring": "N14C[C@@H]2CC[C@H]1C2"
}
|
Can you make molecule COc1ccc2c(c1)C=C(C(=O)N1C[C@@H]3CC[C@H]1C3)CO2 less soluble in water? The output molecule should be similar to the input molecule.
|
COc1ccc2c(c1)C=C(C(=O)[C@H](C)CCCCl)CO2
|
COc1ccc2c(c1)C=C(C(=O)N1C[C@@H]3CC[C@H]1C3)CO2
|
COc1ccc2c(c1)C=C(C(=O)[C@H](C)CCCCl)CO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CCCCl",
"old_substring": "N14C[C@@H]2CC[C@H]1C2"
}
|
Can you make molecule O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1)NCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1I)NCC(F)(F)F
|
O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1)NCC(F)(F)F
|
O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1I)NCC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c19ccc7cc1"
}
|
Can you make molecule O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1)NCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cc1cc(NC(=O)c2ccc3ncsc3c2)ccc1Br)NCC(F)(F)F
|
O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1)NCC(F)(F)F
|
O=C(Cc1cc(NC(=O)c2ccc3ncsc3c2)ccc1Br)NCC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c19ccc7cc1"
}
|
Can you make molecule O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1)NCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1Cl)NCC(F)(F)F
|
O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1)NCC(F)(F)F
|
O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1Cl)NCC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c19ccc7cc1"
}
|
Can you make molecule O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1)NCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cc1cccc(NC(=O)c2ccc3ncsc3c2)c1Br)NCC(F)(F)F
|
O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1)NCC(F)(F)F
|
O=C(Cc1cccc(NC(=O)c2ccc3ncsc3c2)c1Br)NCC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c19ccc7cc1"
}
|
Can you make molecule O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1)NCC(F)(F)F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(Cc1cccc(NC(=O)c2ccc3ncsc3c2)c1Cl)NCC(F)(F)F
|
O=C(Cc1ccc(NC(=O)c2ccc3ncsc3c2)cc1)NCC(F)(F)F
|
O=C(Cc1cccc(NC(=O)c2ccc3ncsc3c2)c1Cl)NCC(F)(F)F
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c19ccc7cc1"
}
|
Can you make molecule CC(C)Oc1cccc(C(=O)[C@@H]2CCCN(C(=O)CCc3ccccn3)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Oc1cccc(C(=O)[C@@H]2N=NC=C2CCC(=O)CCc2ccccn2)c1
|
CC(C)Oc1cccc(C(=O)[C@@H]2CCCN(C(=O)CCc3ccccn3)C2)c1
|
CC(C)Oc1cccc(C(=O)[C@@H]2N=NC=C2CCC(=O)CCc2ccccn2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&N=NC=C1CC&",
"old_substring": "[C@@H]17CCCN4C1"
}
|
Can you make molecule CC(C)Oc1cccc(C(=O)[C@@H]2CCCN(C(=O)CCc3ccccn3)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Oc1cccc(C(=O)[C@@H]2CC[C@@H](C(=O)CCc3ccccn3)C2)c1
|
CC(C)Oc1cccc(C(=O)[C@@H]2CCCN(C(=O)CCc3ccccn3)C2)c1
|
CC(C)Oc1cccc(C(=O)[C@@H]2CC[C@@H](C(=O)CCc3ccccn3)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC[C@@H]&C1",
"old_substring": "[C@@H]17CCCN4C1"
}
|
Can you make molecule CC(C)Oc1cccc(C(=O)[C@@H]2CCCN(C(=O)CCc3ccccn3)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=NC=C(CC(=O)CCc2ccccn2)[C@@H]1C(=O)c1cccc(OC(C)C)c1
|
CC(C)Oc1cccc(C(=O)[C@@H]2CCCN(C(=O)CCc3ccccn3)C2)c1
|
CC1=NC=C(CC(=O)CCc2ccccn2)[C@@H]1C(=O)c1cccc(OC(C)C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C(C&)=CN=C1C",
"old_substring": "[C@@H]17CCCN4C1"
}
|
Can you make molecule CC(C)Oc1cccc(C(=O)[C@@H]2CCCN(C(=O)CCc3ccccn3)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Oc1cccc(C(=O)[C@H](CCl)CCCC(=O)CCc2ccccn2)c1
|
CC(C)Oc1cccc(C(=O)[C@@H]2CCCN(C(=O)CCc3ccccn3)C2)c1
|
CC(C)Oc1cccc(C(=O)[C@H](CCl)CCCC(=O)CCc2ccccn2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]&(CCl)CCC&",
"old_substring": "[C@@H]17CCCN4C1"
}
|
Can you make molecule CC(C)Oc1cccc(C(=O)[C@@H]2CCCN(C(=O)CCc3ccccn3)C2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)Oc1cccc(C(=O)[C@H]2C=C[C@H](C(=O)CCc3ccccn3)C2)c1
|
CC(C)Oc1cccc(C(=O)[C@@H]2CCCN(C(=O)CCc3ccccn3)C2)c1
|
CC(C)Oc1cccc(C(=O)[C@H]2C=C[C@H](C(=O)CCc3ccccn3)C2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&C=C[C@H]&C1",
"old_substring": "[C@@H]17CCCN4C1"
}
|
Can you make molecule C[NH+](CC(=O)NC(C)(C)C)C1CCC2(CC1)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](CCC(=O)NC(C)(C)C)CC1CCC2(CC1)OCCO2
|
C[NH+](CC(=O)NC(C)(C)C)C1CCC2(CC1)OCCO2
|
C[NH+](CCC(=O)NC(C)(C)C)CC1CCC2(CC1)OCCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "C[NH+](C&)C&",
"old_substring": "C[NH+]46"
}
|
Can you make molecule C[NH+](CC(=O)NC(C)(C)C)C1CCC2(CC1)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)NC(=O)CC[NH+]1CCC(C2CCC3(CC2)OCCO3)CC1
|
C[NH+](CC(=O)NC(C)(C)C)C1CCC2(CC1)OCCO2
|
CC(C)(C)NC(=O)CC[NH+]1CCC(C2CCC3(CC2)OCCO3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&CC1",
"old_substring": "C[NH+]46"
}
|
Can you make molecule C[NH+](CC(=O)NC(C)(C)C)C1CCC2(CC1)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)NC(=O)CCC1=CCC[NH+](C2CCC3(CC2)OCCO3)C1
|
C[NH+](CC(=O)NC(C)(C)C)C1CCC2(CC1)OCCO2
|
CC(C)(C)NC(=O)CCC1=CCC[NH+](C2CCC3(CC2)OCCO3)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C1=CCC[NH+]&C1",
"old_substring": "C[NH+]46"
}
|
Can you make molecule C[NH+](CC(=O)NC(C)(C)C)C1CCC2(CC1)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC1(CC(=O)NC(C)(C)C)CC[NH+](C2CCC3(CC2)OCCO3)CC1
|
C[NH+](CC(=O)NC(C)(C)C)C1CCC2(CC1)OCCO2
|
CC1(CC(=O)NC(C)(C)C)CC[NH+](C2CCC3(CC2)OCCO3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(C)CC[NH+]&CC1",
"old_substring": "C[NH+]46"
}
|
Can you make molecule C[NH+](CC(=O)NC(C)(C)C)C1CCC2(CC1)OCCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)NC(=O)CC[NH+]1CCC(C)(C2CCC3(CC2)OCCO3)CC1
|
C[NH+](CC(=O)NC(C)(C)C)C1CCC2(CC1)OCCO2
|
CC(C)(C)NC(=O)CC[NH+]1CCC(C)(C2CCC3(CC2)OCCO3)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[NH+]1CCC&(C)CC1",
"old_substring": "C[NH+]46"
}
|
Can you make molecule CCC(CC)C(=O)[C@H](C)OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)C(=O)[C@H](C)N(CCC1CC1)N=O
|
CCC(CC)C(=O)[C@H](C)OC
|
CCC(CC)C(=O)[C@H](C)N(CCC1CC1)N=O
| 102
|
{
"fragment_index": 0,
"new_substring": "O=NN1CCC&CC1",
"old_substring": "O1C"
}
|
Can you make molecule CCC(CC)C(=O)[C@H](C)OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)C(=O)[C@H](C)S(=O)(=O)CCC1CC1
|
CCC(CC)C(=O)[C@H](C)OC
|
CCC(CC)C(=O)[C@H](C)S(=O)(=O)CCC1CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "O=S1(=O)CCC&CC1",
"old_substring": "O1C"
}
|
Can you make molecule CCC(CC)C(=O)[C@H](C)OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)C(=O)[C@H](C)OP1OCCN1C(C)(C)C
|
CCC(CC)C(=O)[C@H](C)OC
|
CCC(CC)C(=O)[C@H](C)OP1OCCN1C(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "O&P1OCCN1C(C)(C)C",
"old_substring": "O1C"
}
|
Can you make molecule CCC(CC)C(=O)[C@H](C)OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)C(=O)[C@H](C)SCOC
|
CCC(CC)C(=O)[C@H](C)OC
|
CCC(CC)C(=O)[C@H](C)SCOC
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "O1C"
}
|
Can you make molecule CCC(CC)C(=O)[C@H](C)OC less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(CC)C(=O)[C@H](C)OCCl
|
CCC(CC)C(=O)[C@H](C)OC
|
CCC(CC)C(=O)[C@H](C)OCCl
| 102
|
{
"fragment_index": 0,
"new_substring": "O&CCl",
"old_substring": "O1C"
}
|
Can you make molecule CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCC2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCCCCC2=O)cc1
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCC2=O)cc1
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCCCCC2=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCCC1=O",
"old_substring": "N16CCCC1=O"
}
|
Can you make molecule CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCC2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCCC2)cc1
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCC2=O)cc1
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCC1",
"old_substring": "N16CCCC1=O"
}
|
Can you make molecule CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCC2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CC=CCC2)cc1
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCC2=O)cc1
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CC=CCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC=CCC1",
"old_substring": "N16CCCC1=O"
}
|
Can you make molecule CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCC2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCc3sccc3C2=O)cc1
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCC2=O)cc1
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCc3sccc3C2=O)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCc2sccc2C1=O",
"old_substring": "N16CCCC1=O"
}
|
Can you make molecule CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCC2=O)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCCCC2)cc1
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCC2=O)cc1
|
CSc1ccc([C@@H]2[C@@H]3[NH+]=c4ccccc4=C3CCN2C(=O)CCCN2CCCCCC2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCCC1",
"old_substring": "N16CCCC1=O"
}
|
Can you make molecule COc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
|
COc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
|
COCc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO4"
}
|
Can you make molecule COc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
|
COc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
|
COCSc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO4"
}
|
Can you make molecule COc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
|
COc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
|
CC(=O)Sc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO4"
}
|
Can you make molecule COc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)NCc1ccc(OC[C@@H]2CCCO2)c(C(=O)CS)c1
|
COc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
|
CC(C)C(=O)NCc1ccc(OC[C@@H]2CCCO2)c(C(=O)CS)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO4"
}
|
Can you make molecule COc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(=O)NCc1ccc(OC[C@@H]2CCCO2)c(C(=O)CI)c1
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COc1cc(CNC(=O)C(C)C)ccc1OC[C@@H]1CCCO1
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CC(C)C(=O)NCc1ccc(OC[C@@H]2CCCO2)c(C(=O)CI)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO4"
}
|
Can you make molecule Cc1nc2[nH]n(C)c(=O)c2c(C)c1CC(=O)Nc1cncc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1nc2[nH]n(C)c(=O)c2c(C)c1CCC(CO)=Nc1cncc2ccccc12
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Cc1nc2[nH]n(C)c(=O)c2c(C)c1CC(=O)Nc1cncc2ccccc12
|
Cc1nc2[nH]n(C)c(=O)c2c(C)c1CCC(CO)=Nc1cncc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CC=&CO",
"old_substring": "C5C3=O"
}
|
Can you make molecule Cc1nc2[nH]n(C)c(=O)c2c(C)c1CC(=O)Nc1cncc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
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C/C(Cc1c(C)nc2[nH]n(C)c(=O)c2c1C)=N/ONc1cncc2ccccc12
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Cc1nc2[nH]n(C)c(=O)c2c(C)c1CC(=O)Nc1cncc2ccccc12
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C/C(Cc1c(C)nc2[nH]n(C)c(=O)c2c1C)=N/ONc1cncc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "C/C(C&)=N/O&",
"old_substring": "C5C3=O"
}
|
Can you make molecule Cc1nc2[nH]n(C)c(=O)c2c(C)c1CC(=O)Nc1cncc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(CC)(C(=O)CNc1cncc2ccccc12)c1c(C)nc2[nH]n(C)c(=O)c2c1C
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Cc1nc2[nH]n(C)c(=O)c2c(C)c1CC(=O)Nc1cncc2ccccc12
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CCC(CC)(C(=O)CNc1cncc2ccccc12)c1c(C)nc2[nH]n(C)c(=O)c2c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)C&",
"old_substring": "C5C3=O"
}
|
Can you make molecule Cc1nc2[nH]n(C)c(=O)c2c(C)c1CC(=O)Nc1cncc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1nc2[nH]n(C)c(=O)c2c(C)c1SSC(=O)Nc1cncc2ccccc12
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Cc1nc2[nH]n(C)c(=O)c2c(C)c1CC(=O)Nc1cncc2ccccc12
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Cc1nc2[nH]n(C)c(=O)c2c(C)c1SSC(=O)Nc1cncc2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SC&=O",
"old_substring": "C5C3=O"
}
|
Can you make molecule Cc1nc2[nH]n(C)c(=O)c2c(C)c1CC(=O)Nc1cncc2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(CC)(C(=O)CCNc1cncc2ccccc12)c1c(C)nc2[nH]n(C)c(=O)c2c1C
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Cc1nc2[nH]n(C)c(=O)c2c(C)c1CC(=O)Nc1cncc2ccccc12
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CCC(CC)(C(=O)CCNc1cncc2ccccc12)c1c(C)nc2[nH]n(C)c(=O)c2c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "CCC&(CC)C(=O)CC&",
"old_substring": "C5C3=O"
}
|
Can you make molecule O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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O=C1C=CO[C@@H](NC(=O)c2ccc(CNS(=O)(=O)c3ccccc3)cc2)C1
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O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
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O=C1C=CO[C@@H](NC(=O)c2ccc(CNS(=O)(=O)c3ccccc3)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CC(=O)C=CO1",
"old_substring": "[C@@H]16CCS(=O)(=O)C1"
}
|
Can you make molecule O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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O=C1C[C@@H](NC(=O)c2ccc(CNS(=O)(=O)c3ccccc3)cc2)CS1
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O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
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O=C1C[C@@H](NC(=O)c2ccc(CNS(=O)(=O)c3ccccc3)cc2)CS1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@H]1&CSC(=O)C1",
"old_substring": "[C@@H]16CCS(=O)(=O)C1"
}
|
Can you make molecule O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(N[C@@H]1CC(F)(F)CN1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
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O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
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O=C(N[C@@H]1CC(F)(F)CN1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CC(F)(F)CN1",
"old_substring": "[C@@H]16CCS(=O)(=O)C1"
}
|
Can you make molecule O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(N[C@@H]1CCSC1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
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O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
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O=C(N[C@@H]1CCSC1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&CCSC1",
"old_substring": "[C@@H]16CCS(=O)(=O)C1"
}
|
Can you make molecule O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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O=C(N[C@@H]1C=C(O)N=N1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
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O=C(N[C@@H]1CCS(=O)(=O)C1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
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O=C(N[C@@H]1C=C(O)N=N1)c1ccc(CNS(=O)(=O)c2ccccc2)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "[C@@H]1&C=C(O)N=N1",
"old_substring": "[C@@H]16CCS(=O)(=O)C1"
}
|
Can you make molecule CNC(=O)c1ccc(Cl)cc1[N-]S(=O)(=O)c1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
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CN1CCC(C(=O)c2ccc(Cl)cc2[N-]S(=O)(=O)c2ccccc2Cl)=CC2=CC=C21
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CNC(=O)c1ccc(Cl)cc1[N-]S(=O)(=O)c1ccccc1Cl
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CN1CCC(C(=O)c2ccc(Cl)cc2[N-]S(=O)(=O)c2ccccc2Cl)=CC2=CC=C21
| 102
|
{
"fragment_index": 0,
"new_substring": "CN1CCc2cc&ccc21",
"old_substring": "CN2"
}
|
Can you make molecule CNC(=O)c1ccc(Cl)cc1[N-]S(=O)(=O)c1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
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CN1CCC(C(=O)c2ccc(Cl)cc2[N-]S(=O)(=O)c2ccccc2Cl)=NC2=C(C1)S2
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CNC(=O)c1ccc(Cl)cc1[N-]S(=O)(=O)c1ccccc1Cl
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CN1CCC(C(=O)c2ccc(Cl)cc2[N-]S(=O)(=O)c2ccccc2Cl)=NC2=C(C1)S2
| 102
|
{
"fragment_index": 0,
"new_substring": "CN1CCc2nc&sc2C1",
"old_substring": "CN2"
}
|
Can you make molecule CNC(=O)c1ccc(Cl)cc1[N-]S(=O)(=O)c1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
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CN1CCCC(C(=O)c2ccc(Cl)cc2[N-]S(=O)(=O)c2ccccc2Cl)=CC2=C1S2
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CNC(=O)c1ccc(Cl)cc1[N-]S(=O)(=O)c1ccccc1Cl
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CN1CCCC(C(=O)c2ccc(Cl)cc2[N-]S(=O)(=O)c2ccccc2Cl)=CC2=C1S2
| 102
|
{
"fragment_index": 0,
"new_substring": "CN1CCCc2cc&sc21",
"old_substring": "CN2"
}
|
Can you make molecule CNC(=O)c1ccc(Cl)cc1[N-]S(=O)(=O)c1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
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CN1CCC(C(=O)c2ccc(Cl)cc2[N-]S(=O)(=O)c2ccccc2Cl)=CC=C2C=C2C1=O
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CNC(=O)c1ccc(Cl)cc1[N-]S(=O)(=O)c1ccccc1Cl
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CN1CCC(C(=O)c2ccc(Cl)cc2[N-]S(=O)(=O)c2ccccc2Cl)=CC=C2C=C2C1=O
| 102
|
{
"fragment_index": 0,
"new_substring": "CN1CCc2ccc&cc2C1=O",
"old_substring": "CN2"
}
|
Can you make molecule CNC(=O)c1ccc(Cl)cc1[N-]S(=O)(=O)c1ccccc1Cl less soluble in water? The output molecule should be similar to the input molecule.
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CN1C(C(=O)c2ccc(Cl)cc2[N-]S(=O)(=O)c2ccccc2Cl)=CC=CC=C2C1N2C
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CNC(=O)c1ccc(Cl)cc1[N-]S(=O)(=O)c1ccccc1Cl
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CN1C(C(=O)c2ccc(Cl)cc2[N-]S(=O)(=O)c2ccccc2Cl)=CC=CC=C2C1N2C
| 102
|
{
"fragment_index": 0,
"new_substring": "CN1c2ccccc2N(C)C1&",
"old_substring": "CN2"
}
|
Can you make molecule CCC(=O)Nc1cccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(OC)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)Nc1cccc(C(=O)N(C)C(=S)Sc2ccccc2C(=O)Nc2ccc(OC)cc2)c1
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CCC(=O)Nc1cccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(OC)cc2)c1
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CCC(=O)Nc1cccc(C(=O)N(C)C(=S)Sc2ccccc2C(=O)Nc2ccc(OC)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CN&C(=S)S&",
"old_substring": "N48"
}
|
Can you make molecule CCC(=O)Nc1cccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(OC)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(=O)Nc1cccc(C(=O)N2CCN=C2Sc2ccccc2C(=O)Nc2ccc(OC)cc2)c1
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CCC(=O)Nc1cccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(OC)cc2)c1
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CCC(=O)Nc1cccc(C(=O)N2CCN=C2Sc2ccccc2C(=O)Nc2ccc(OC)cc2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCN=C1S&",
"old_substring": "N48"
}
|
Can you make molecule CCC(=O)Nc1cccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(OC)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(=O)Nc1cccc(C(=O)CN2CCC(c3ccccc3C(=O)Nc3ccc(OC)cc3)CC2)c1
|
CCC(=O)Nc1cccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(OC)cc2)c1
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CCC(=O)Nc1cccc(C(=O)CN2CCC(c3ccccc3C(=O)Nc3ccc(OC)cc3)CC2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&N1CCC&CC1",
"old_substring": "N48"
}
|
Can you make molecule CCC(=O)Nc1cccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(OC)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(=O)Nc1cccc(C(=O)c2cccc(-c3ccccc3C(=O)Nc3ccc(OC)cc3)c2N)c1
|
CCC(=O)Nc1cccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(OC)cc2)c1
|
CCC(=O)Nc1cccc(C(=O)c2cccc(-c3ccccc3C(=O)Nc3ccc(OC)cc3)c2N)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1c&cccc1&",
"old_substring": "N48"
}
|
Can you make molecule CCC(=O)Nc1cccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(OC)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(=O)Nc1cccc(C(=O)c2cc(N)cc(-c3ccccc3C(=O)Nc3ccc(OC)cc3)c2)c1
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CCC(=O)Nc1cccc(C(=O)Nc2ccccc2C(=O)Nc2ccc(OC)cc2)c1
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CCC(=O)Nc1cccc(C(=O)c2cc(N)cc(-c3ccccc3C(=O)Nc3ccc(OC)cc3)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Nc1cc&cc&c1",
"old_substring": "N48"
}
|
Can you make molecule C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
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C[C@H](CCNC(=O)c1ccoc1)CC(=O)N1CCN(Cc2ccsc2)CC1
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C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1
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C[C@H](CCNC(=O)c1ccoc1)CC(=O)N1CCN(Cc2ccsc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H](CC&)CC&=O",
"old_substring": "C[C@H]5C4=O"
}
|
Can you make molecule C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
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C[C@@H](CCNC(=O)c1ccoc1)CC(=O)N1CCN(Cc2ccsc2)CC1
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C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1
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C[C@@H](CCNC(=O)c1ccoc1)CC(=O)N1CCN(Cc2ccsc2)CC1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H](CC&)CC&=O",
"old_substring": "C[C@H]5C4=O"
}
|
Can you make molecule C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
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C[C@@H](CCN1CCN(Cc2ccsc2)CC1)NC(=O)c1ccoc1
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C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1
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C[C@@H](CCN1CCN(Cc2ccsc2)CC1)NC(=O)c1ccoc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]&CC&",
"old_substring": "C[C@H]5C4=O"
}
|
Can you make molecule C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@](CO)(CCCN1CCN(Cc2ccsc2)CC1)NC(=O)c1ccoc1
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C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1
|
C[C@](CO)(CCCN1CCN(Cc2ccsc2)CC1)NC(=O)c1ccoc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@]&(CO)CCC&",
"old_substring": "C[C@H]5C4=O"
}
|
Can you make molecule C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](CC(C)(C)N1CCN(Cc2ccsc2)CC1)NC(=O)c1ccoc1
|
C[C@H](NC(=O)c1ccoc1)C(=O)N1CCN(Cc2ccsc2)CC1
|
C[C@H](CC(C)(C)N1CCN(Cc2ccsc2)CC1)NC(=O)c1ccoc1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@@H]&CC&(C)C",
"old_substring": "C[C@H]5C4=O"
}
|
Can you make molecule O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2Cl)C1
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2)C1
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2Cl)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c19ccccc1"
}
|
Can you make molecule O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccc(I)cc2)C1
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2)C1
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccc(I)cc2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c19ccccc1"
}
|
Can you make molecule O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(N2C[C@@H](C(=O)NCC[NH+]3CCN(C(=O)c4ccccc4[N+](=O)[O-])CC3)CC2=O)cc1I
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2)C1
|
Cc1ccc(N2C[C@@H](C(=O)NCC[NH+]3CCN(C(=O)c4ccccc4[N+](=O)[O-])CC3)CC2=O)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c19ccccc1"
}
|
Can you make molecule O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2cccc(Br)c2)C1
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2)C1
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2cccc(Br)c2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c19ccccc1"
}
|
Can you make molecule O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1cccc(N2C[C@@H](C(=O)NCC[NH+]3CCN(C(=O)c4ccccc4[N+](=O)[O-])CC3)CC2=O)c1C
|
O=C(NCC[NH+]1CCN(C(=O)c2ccccc2[N+](=O)[O-])CC1)[C@H]1CC(=O)N(c2ccccc2)C1
|
Cc1cccc(N2C[C@@H](C(=O)NCC[NH+]3CCN(C(=O)c4ccccc4[N+](=O)[O-])CC3)CC2=O)c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c19ccccc1"
}
|
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