prompt
stringlengths 120
209
| completion
stringlengths 15
103
| input_smiles
stringlengths 14
103
| output_smiles
stringlengths 15
103
| task_id
int64 102
102
| winner_action
dict |
|---|---|---|---|---|---|
Can you make molecule COc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
|
COc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
|
COCc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
|
COc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
|
COCSc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
|
COc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
|
CC(=O)Sc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CS)c1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
|
COc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
|
O=C(CS)c1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CI)c1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
|
COc1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
|
O=C(CI)c1ccc(OC(=O)[C@H]2SCCc3sccc32)cc1F
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
Can you make molecule Cc1nc(-c2ccc(Br)cc2)[nH]c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(Br)cc2I)[nH]c1C
|
Cc1nc(-c2ccc(Br)cc2)[nH]c1C
|
Cc1nc(-c2ccc(Br)cc2I)[nH]c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)cc1I",
"old_substring": "c13ccc(Br)cc1"
}
|
Can you make molecule Cc1nc(-c2ccc(Br)cc2)[nH]c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(Br)cc2Br)[nH]c1C
|
Cc1nc(-c2ccc(Br)cc2)[nH]c1C
|
Cc1nc(-c2ccc(Br)cc2Br)[nH]c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)cc1Br",
"old_substring": "c13ccc(Br)cc1"
}
|
Can you make molecule Cc1nc(-c2ccc(Br)cc2)[nH]c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2cc(Br)ccc2I)[nH]c1C
|
Cc1nc(-c2ccc(Br)cc2)[nH]c1C
|
Cc1nc(-c2cc(Br)ccc2I)[nH]c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccc1I",
"old_substring": "c13ccc(Br)cc1"
}
|
Can you make molecule Cc1nc(-c2ccc(Br)cc2)[nH]c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2ccc(Br)c(Cl)c2F)[nH]c1C
|
Cc1nc(-c2ccc(Br)cc2)[nH]c1C
|
Cc1nc(-c2ccc(Br)c(Cl)c2F)[nH]c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)c(Cl)c1F",
"old_substring": "c13ccc(Br)cc1"
}
|
Can you make molecule Cc1nc(-c2ccc(Br)cc2)[nH]c1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1nc(-c2cc(Br)ccc2Cl)[nH]c1C
|
Cc1nc(-c2ccc(Br)cc2)[nH]c1C
|
Cc1nc(-c2cc(Br)ccc2Cl)[nH]c1C
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Br)ccc1Cl",
"old_substring": "c13ccc(Br)cc1"
}
|
Can you make molecule C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Cl)c1Cl
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Br)c1
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(Cl)c1Cl",
"old_substring": "c13ccc(Cl)c(Br)c1"
}
|
Can you make molecule C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1c(Br)cc(Cl)cc1Br
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Br)c1
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1c(Br)cc(Cl)cc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(Br)cc(Cl)cc1Br",
"old_substring": "c13ccc(Cl)c(Br)c1"
}
|
Can you make molecule C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1c(Cl)cc(Br)cc1Cl
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Br)c1
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1c(Cl)cc(Br)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(Cl)cc(Br)cc1Cl",
"old_substring": "c13ccc(Cl)c(Br)c1"
}
|
Can you make molecule C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1cc(Cl)cc(Cl)c1Br
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Br)c1
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1cc(Cl)cc(Cl)c1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(Cl)cc(Cl)c1Br",
"old_substring": "c13ccc(Cl)c(Br)c1"
}
|
Can you make molecule C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Br)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1c(Cl)ccc(Cl)c1Cl
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1ccc(Cl)c(Br)c1
|
C[NH+]1CCC2(CC1)CNC(=N)N2c1c(Cl)ccc(Cl)c1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&c(Cl)ccc(Cl)c1Cl",
"old_substring": "c13ccc(Cl)c(Br)c1"
}
|
Can you make molecule Cc1ccc(CNC(=O)N[C@H](C)CN2CCOCC2)n1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCCC2)n1C
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCOCC2)n1C
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCCC2)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCC1",
"old_substring": "N17CCOCC1"
}
|
Can you make molecule Cc1ccc(CNC(=O)N[C@H](C)CN2CCOCC2)n1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCCCC2)n1C
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCOCC2)n1C
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCCCC2)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCCCC1",
"old_substring": "N17CCOCC1"
}
|
Can you make molecule Cc1ccc(CNC(=O)N[C@H](C)CN2CCOCC2)n1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCSCC2)n1C
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCOCC2)n1C
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCSCC2)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCSCC1",
"old_substring": "N17CCOCC1"
}
|
Can you make molecule Cc1ccc(CNC(=O)N[C@H](C)CN2CCOCC2)n1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CC=CC2)n1C
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCOCC2)n1C
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CC=CC2)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CC=CC1",
"old_substring": "N17CCOCC1"
}
|
Can you make molecule Cc1ccc(CNC(=O)N[C@H](C)CN2CCOCC2)n1C less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(CNC(=O)N[C@H](C)CSSN2CCOCC2)n1C
|
Cc1ccc(CNC(=O)N[C@H](C)CN2CCOCC2)n1C
|
Cc1ccc(CNC(=O)N[C@H](C)CSSN2CCOCC2)n1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&SN1CCOCC1",
"old_substring": "N17CCOCC1"
}
|
Can you make molecule C#Cc1cccc(N(Cc2ccco2)C(=O)COCC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(N(Cc2ccc(I)o2)C(=O)COCC)c1
|
C#Cc1cccc(N(Cc2ccco2)C(=O)COCC)c1
|
C#Cc1cccc(N(Cc2ccc(I)o2)C(=O)COCC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)o1",
"old_substring": "c18ccco1"
}
|
Can you make molecule C#Cc1cccc(N(Cc2ccco2)C(=O)COCC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(N(Cc2ccc(Br)o2)C(=O)COCC)c1
|
C#Cc1cccc(N(Cc2ccco2)C(=O)COCC)c1
|
C#Cc1cccc(N(Cc2ccc(Br)o2)C(=O)COCC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Br)o1",
"old_substring": "c18ccco1"
}
|
Can you make molecule C#Cc1cccc(N(Cc2ccco2)C(=O)COCC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(N(Cc2ccc(Cl)o2)C(=O)COCC)c1
|
C#Cc1cccc(N(Cc2ccco2)C(=O)COCC)c1
|
C#Cc1cccc(N(Cc2ccc(Cl)o2)C(=O)COCC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)o1",
"old_substring": "c18ccco1"
}
|
Can you make molecule C#Cc1cccc(N(Cc2ccco2)C(=O)COCC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(N(Cc2occc2Br)C(=O)COCC)c1
|
C#Cc1cccc(N(Cc2ccco2)C(=O)COCC)c1
|
C#Cc1cccc(N(Cc2occc2Br)C(=O)COCC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&occc1Br",
"old_substring": "c18ccco1"
}
|
Can you make molecule C#Cc1cccc(N(Cc2ccco2)C(=O)COCC)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
C#Cc1cccc(N(Cc2sccc2C)C(=O)COCC)c1
|
C#Cc1cccc(N(Cc2ccco2)C(=O)COCC)c1
|
C#Cc1cccc(N(Cc2sccc2C)C(=O)COCC)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&sccc1C",
"old_substring": "c18ccco1"
}
|
Can you make molecule C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)Cc1n[nH]c(=O)c2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)CCN(Cc1ccc(F)cc1Cl)C(=O)Cc1n[nH]c(=O)c2ccccc12
|
C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)Cc1n[nH]c(=O)c2ccccc12
|
C[NH+](C)CCN(Cc1ccc(F)cc1Cl)C(=O)Cc1n[nH]c(=O)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c18ccc(F)cc1"
}
|
Can you make molecule C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)Cc1n[nH]c(=O)c2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)CCN(Cc1ccc(F)cc1Br)C(=O)Cc1n[nH]c(=O)c2ccccc12
|
C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)Cc1n[nH]c(=O)c2ccccc12
|
C[NH+](C)CCN(Cc1ccc(F)cc1Br)C(=O)Cc1n[nH]c(=O)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Br",
"old_substring": "c18ccc(F)cc1"
}
|
Can you make molecule C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)Cc1n[nH]c(=O)c2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)CCN(Cc1ccc(F)c(Cl)c1)C(=O)Cc1n[nH]c(=O)c2ccccc12
|
C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)Cc1n[nH]c(=O)c2ccccc12
|
C[NH+](C)CCN(Cc1ccc(F)c(Cl)c1)C(=O)Cc1n[nH]c(=O)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)c(Cl)c1",
"old_substring": "c18ccc(F)cc1"
}
|
Can you make molecule C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)Cc1n[nH]c(=O)c2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)CCN(Cc1ccc(I)cc1F)C(=O)Cc1n[nH]c(=O)c2ccccc12
|
C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)Cc1n[nH]c(=O)c2ccccc12
|
C[NH+](C)CCN(Cc1ccc(I)cc1F)C(=O)Cc1n[nH]c(=O)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1F",
"old_substring": "c18ccc(F)cc1"
}
|
Can you make molecule C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)Cc1n[nH]c(=O)c2ccccc12 less soluble in water? The output molecule should be similar to the input molecule.
|
C[NH+](C)CCN(Cc1cc2c(F)cccc2s1)C(=O)Cc1n[nH]c(=O)c2ccccc12
|
C[NH+](C)CCN(Cc1ccc(F)cc1)C(=O)Cc1n[nH]c(=O)c2ccccc12
|
C[NH+](C)CCN(Cc1cc2c(F)cccc2s1)C(=O)Cc1n[nH]c(=O)c2ccccc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2c(F)cccc2s1",
"old_substring": "c18ccc(F)cc1"
}
|
Can you make molecule Nc1nc(-c2cccc(F)c2)c(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nc1nc(-c2cc3cc(F)ccc3s2)c(Br)s1
|
Nc1nc(-c2cccc(F)c2)c(Br)s1
|
Nc1nc(-c2cc3cc(F)ccc3s2)c(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc2cc(F)ccc2s1",
"old_substring": "c13cccc(F)c1"
}
|
Can you make molecule Nc1nc(-c2cccc(F)c2)c(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(Br)cccc1-c1nc(N)sc1Br
|
Nc1nc(-c2cccc(F)c2)c(Br)s1
|
Cc1c(Br)cccc1-c1nc(N)sc1Br
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(Br)c1C",
"old_substring": "c13cccc(F)c1"
}
|
Can you make molecule Nc1nc(-c2cccc(F)c2)c(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1c(-c2nc(N)sc2Br)oc2ccc(F)cc12
|
Nc1nc(-c2cccc(F)c2)c(Br)s1
|
Cc1c(-c2nc(N)sc2Br)oc2ccc(F)cc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&oc2ccc(F)cc2c1C",
"old_substring": "c13cccc(F)c1"
}
|
Can you make molecule Nc1nc(-c2cccc(F)c2)c(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nc1nc(-c2cc(F)ccc2Br)c(Br)s1
|
Nc1nc(-c2cccc(F)c2)c(Br)s1
|
Nc1nc(-c2cc(F)ccc2Br)c(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc(F)ccc1Br",
"old_substring": "c13cccc(F)c1"
}
|
Can you make molecule Nc1nc(-c2cccc(F)c2)c(Br)s1 less soluble in water? The output molecule should be similar to the input molecule.
|
Nc1nc(-c2ccc(F)cc2Cl)c(Br)s1
|
Nc1nc(-c2cccc(F)c2)c(Br)s1
|
Nc1nc(-c2ccc(F)cc2Cl)c(Br)s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(F)cc1Cl",
"old_substring": "c13cccc(F)c1"
}
|
Can you make molecule CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)F)cc2)NC(=O)N1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(SC(F)(F)F)cc2)NC(=O)N1C
|
CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)F)cc2)NC(=O)N1C
|
CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(SC(F)(F)F)cc2)NC(=O)N1C
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)F)cc2)NC(=O)N1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(CCCC(F)(F)F)cc2)NC(=O)N1C
|
CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)F)cc2)NC(=O)N1C
|
CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(CCCC(F)(F)F)cc2)NC(=O)N1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCC(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)F)cc2)NC(=O)N1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(CCCCC(F)(F)F)cc2)NC(=O)N1C
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CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)F)cc2)NC(=O)N1C
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CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(CCCCC(F)(F)F)cc2)NC(=O)N1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&CCCC(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)F)cc2)NC(=O)N1C less soluble in water? The output molecule should be similar to the input molecule.
|
CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)C(F)(F)F)cc2)NC(=O)N1C
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CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)F)cc2)NC(=O)N1C
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CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)C(F)(F)F)cc2)NC(=O)N1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(F)(F)C(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)F)cc2)NC(=O)N1C less soluble in water? The output molecule should be similar to the input molecule.
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CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(CC(F)(F)C(F)(F)F)cc2)NC(=O)N1C
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CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(C(F)(F)F)cc2)NC(=O)N1C
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CC1=C(C(=O)OC[C@H]2CCCO2)[C@H](c2ccc(CC(F)(F)C(F)(F)F)cc2)NC(=O)N1C
| 102
|
{
"fragment_index": 0,
"new_substring": "C&C(F)(F)C(F)(F)F",
"old_substring": "C6(F)(F)F"
}
|
Can you make molecule Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1I
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Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1
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Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1I
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "Cc1ccc4cc1"
}
|
Can you make molecule Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1Cl
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Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1
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Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1Cl
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1Cl",
"old_substring": "Cc1ccc4cc1"
}
|
Can you make molecule Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1cc(I)ccc1SC/C([O-])=N/S(=O)(=O)c1ccccc1C
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Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1
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Cc1cc(I)ccc1SC/C([O-])=N/S(=O)(=O)c1ccccc1C
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc(I)ccc1&",
"old_substring": "Cc1ccc4cc1"
}
|
Can you make molecule Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1ccc(I)c(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)c1
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Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1
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Cc1ccc(I)c(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(I)c&c1",
"old_substring": "Cc1ccc4cc1"
}
|
Can you make molecule Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1ccc(Br)c(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)c1
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Cc1ccc(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)cc1
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Cc1ccc(Br)c(SC/C([O-])=N/S(=O)(=O)c2ccccc2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc(Br)c&c1",
"old_substring": "Cc1ccc4cc1"
}
|
Can you make molecule Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1n[nH]c(-c2cccc(CNSC(=O)Cc3cccc(OC(C)C)c3)c2)n1
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Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1
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Cc1n[nH]c(-c2cccc(CNSC(=O)Cc3cccc(OC(C)C)c3)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C4(=O)C9"
}
|
Can you make molecule Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1n[nH]c(-c2cccc(CNC(=O)CCCC(=O)c3cccc(OC(C)C)c3)c2)n1
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Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1
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Cc1n[nH]c(-c2cccc(CNC(=O)CCCC(=O)c3cccc(OC(C)C)c3)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C4(=O)C9"
}
|
Can you make molecule Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1 less soluble in water? The output molecule should be similar to the input molecule.
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Cc1n[nH]c(-c2cccc(CNC(=O)CC(C)(C)c3cccc(OC(C)C)c3)c2)n1
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Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1
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Cc1n[nH]c(-c2cccc(CNC(=O)CC(C)(C)c3cccc(OC(C)C)c3)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C4(=O)C9"
}
|
Can you make molecule Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1n[nH]c(-c2cccc(CNC[S@+]([O-])CCCc3cccc(OC(C)C)c3)c2)n1
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Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1
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Cc1n[nH]c(-c2cccc(CNC[S@+]([O-])CCCc3cccc(OC(C)C)c3)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C4(=O)C9"
}
|
Can you make molecule Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1 less soluble in water? The output molecule should be similar to the input molecule.
|
Cc1n[nH]c(-c2cccc(CNC(=O)CCC(C)(C)c3cccc(OC(C)C)c3)c2)n1
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Cc1n[nH]c(-c2cccc(CNC(=O)Cc3cccc(OC(C)C)c3)c2)n1
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Cc1n[nH]c(-c2cccc(CNC(=O)CCC(C)(C)c3cccc(OC(C)C)c3)c2)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C4(=O)C9"
}
|
Can you make molecule CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2I)cc1
|
CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2)cc1
|
CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2I)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1I",
"old_substring": "c18ccc6cc1"
}
|
Can you make molecule CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2cc(OC)ccc2Br)cc1
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CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2)cc1
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CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2cc(OC)ccc2Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&ccc1Br",
"old_substring": "c18ccc6cc1"
}
|
Can you make molecule CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
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CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2Cl)cc1
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CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2)cc1
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CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc&cc1Cl",
"old_substring": "c18ccc6cc1"
}
|
Can you make molecule CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2cccc(OC)c2Br)cc1
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CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2)cc1
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CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2cccc(OC)c2Br)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Br",
"old_substring": "c18ccc6cc1"
}
|
Can you make molecule CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2cccc(OC)c2Cl)cc1
|
CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2ccc(OC)cc2)cc1
|
CCC(=O)c1ccc(OCC(=O)N2CCC[C@H]2c2cccc(OC)c2Cl)cc1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc&c1Cl",
"old_substring": "c18ccc6cc1"
}
|
Can you make molecule CC(C)(C)[C@H](NC(=O)c1ccc(C#N)cn1)C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)[C@H](NSC(=O)Cc1ccc(C#N)cn1)C(N)=O
|
CC(C)(C)[C@H](NC(=O)c1ccc(C#N)cn1)C(N)=O
|
CC(C)(C)[C@H](NSC(=O)Cc1ccc(C#N)cn1)C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C24=O"
}
|
Can you make molecule CC(C)(C)[C@H](NC(=O)c1ccc(C#N)cn1)C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)[C@H](NC(=O)CCCC(=O)c1ccc(C#N)cn1)C(N)=O
|
CC(C)(C)[C@H](NC(=O)c1ccc(C#N)cn1)C(N)=O
|
CC(C)(C)[C@H](NC(=O)CCCC(=O)c1ccc(C#N)cn1)C(N)=O
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C24=O"
}
|
Can you make molecule CC(C)(C)[C@H](NC(=O)c1ccc(C#N)cn1)C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CC(=O)N[C@H](C(N)=O)C(C)(C)C)c1ccc(C#N)cn1
|
CC(C)(C)[C@H](NC(=O)c1ccc(C#N)cn1)C(N)=O
|
CC(C)(CC(=O)N[C@H](C(N)=O)C(C)(C)C)c1ccc(C#N)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule CC(C)(C)[C@H](NC(=O)c1ccc(C#N)cn1)C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC(=O)N[C@H](C(N)=O)C(C)(C)C)c1ccc(C#N)cn1
|
CC(C)(C)[C@H](NC(=O)c1ccc(C#N)cn1)C(N)=O
|
CC(C)(CCC(=O)N[C@H](C(N)=O)C(C)(C)C)c1ccc(C#N)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C24=O"
}
|
Can you make molecule CC(C)(C)[C@H](NC(=O)c1ccc(C#N)cn1)C(N)=O less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](C(=O)SN[C@H](C(N)=O)C(C)(C)C)c1ccc(C#N)cn1
|
CC(C)(C)[C@H](NC(=O)c1ccc(C#N)cn1)C(N)=O
|
C[C@H](C(=O)SN[C@H](C(N)=O)C(C)(C)C)c1ccc(C#N)cn1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)[C@H]&C",
"old_substring": "C24=O"
}
|
Can you make molecule COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C[NH2+][C@@H]1C[C@H]1c1ccccc1)C(=O)C1OCc2ccccc2CO1
|
COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1
|
CC(C)(C[NH2+][C@@H]1C[C@H]1c1ccccc1)C(=O)C1OCc2ccccc2CO1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&OCc2ccccc2CO1",
"old_substring": "CO2"
}
|
Can you make molecule COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C[NH2+][C@@H]1C[C@H]1c1ccccc1)C(=O)C1(O)Cc2ccccc2C1
|
COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1
|
CC(C)(C[NH2+][C@@H]1C[C@H]1c1ccccc1)C(=O)C1(O)Cc2ccccc2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C1&(O)Cc2ccccc2C1",
"old_substring": "CO2"
}
|
Can you make molecule COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1COC(C(=O)C(C)(C)C[NH2+][C@@H]2C[C@H]2c2ccccc2)=CC2=NN2C1
|
COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1
|
C[C@H]1COC(C(=O)C(C)(C)C[NH2+][C@@H]2C[C@H]2c2ccccc2)=CC2=NN2C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C[C@H]1COc2cc&nn2C1",
"old_substring": "CO2"
}
|
Can you make molecule COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C[NH2+][C@@H]1C[C@H]1c1ccccc1)C(=O)N1CCOC12CCCCC2
|
COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1
|
CC(C)(C[NH2+][C@@H]1C[C@H]1c1ccccc1)C(=O)N1CCOC12CCCCC2
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOC12CCCCC2",
"old_substring": "CO2"
}
|
Can you make molecule COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C[NH2+][C@@H]1C[C@H]1c1ccccc1)C(=O)N1CCOC2(CCC2)C1
|
COC(=O)C(C)(C)C[NH2+][C@@H]1C[C@H]1c1ccccc1
|
CC(C)(C[NH2+][C@@H]1C[C@H]1c1ccccc1)C(=O)N1CCOC2(CCC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "N1&CCOC2(CCC2)C1",
"old_substring": "CO2"
}
|
Can you make molecule CC(C)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)C(C(C)C)[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
|
CC(C)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
|
CC(C)C(C(C)C)[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)C&C(C)C",
"old_substring": "CC(C)C7"
}
|
Can you make molecule CC(C)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(CCC#N)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
|
CC(C)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
|
CC(C)(CCC#N)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)(C&)CCC#N",
"old_substring": "CC(C)C7"
}
|
Can you make molecule CC(C)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)[C@H](CI)[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
|
CC(C)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
|
CC(C)[C@H](CI)[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)[C@@H]&CI",
"old_substring": "CC(C)C7"
}
|
Can you make molecule CC(C)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)(C)NC(=O)NC(=O)CN1CCOC[C@@H]1C(C)(C)CCBr
|
CC(C)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
|
CC(C)(C)NC(=O)NC(=O)CN1CCOC[C@@H]1C(C)(C)CCBr
| 102
|
{
"fragment_index": 0,
"new_substring": "CC&(C)CCBr",
"old_substring": "CC(C)C7"
}
|
Can you make molecule CC(C)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C less soluble in water? The output molecule should be similar to the input molecule.
|
CC(C)CC[C@H](C)[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
|
CC(C)C[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
|
CC(C)CC[C@H](C)[C@H]1COCCN1CC(=O)NC(=O)NC(C)(C)C
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(C)CC[C@@H]&C",
"old_substring": "CC(C)C7"
}
|
Can you make molecule CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3Cl)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3Cl)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccccc1Cl",
"old_substring": "c16ccccc1"
}
|
Can you make molecule CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccc(I)cc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccc(I)cc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(I)cc1",
"old_substring": "c16ccccc1"
}
|
Can you make molecule CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccc(C)c(I)c3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccc(C)c(I)c3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1ccc&cc1I",
"old_substring": "c16ccccc1"
}
|
Can you make molecule CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N1NC(=C2C(=O)N(Cc3cccc(Br)c3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
|
CCC(=O)N1NC(=C2C(=O)N(Cc3cccc(Br)c3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "Brc1cccc&c1",
"old_substring": "c16ccccc1"
}
|
Can you make molecule CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2 less soluble in water? The output molecule should be similar to the input molecule.
|
CCC(=O)N1NC(=C2C(=O)N(Cc3cccc(C)c3C)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
|
CCC(=O)N1NC(=C2C(=O)N(Cc3ccccc3)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
|
CCC(=O)N1NC(=C2C(=O)N(Cc3cccc(C)c3C)C(=O)N=C2[O-])C[C@H]1c1ccc2c(c1)OCO2
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cccc(C)c1C",
"old_substring": "c16ccccc1"
}
|
Can you make molecule C[C@H]1CCC[C@H](NC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCC[C@H](NSC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
|
C[C@H]1CCC[C@H](NC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
|
C[C@H]1CCC[C@H](NSC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "S&C(=O)C&",
"old_substring": "C4(=O)C7"
}
|
Can you make molecule C[C@H]1CCC[C@H](NC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCC[C@H](NC(=O)CCCC(=O)N2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
|
C[C@H]1CCC[C@H](NC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
|
C[C@H]1CCC[C@H](NC(=O)CCCC(=O)N2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCCC&=O",
"old_substring": "C4(=O)C7"
}
|
Can you make molecule C[C@H]1CCC[C@H](NC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCC[C@H](NC(=O)CC(C)(C)N2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
|
C[C@H]1CCC[C@H](NC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
|
C[C@H]1CCC[C@H](NC(=O)CC(C)(C)N2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CC&(C)C",
"old_substring": "C4(=O)C7"
}
|
Can you make molecule C[C@H]1CCC[C@H](NC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCC[C@H](NC[S@+]([O-])CCCN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
|
C[C@H]1CCC[C@H](NC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
|
C[C@H]1CCC[C@H](NC[S@+]([O-])CCCN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&[S@](=O)CCC&",
"old_substring": "C4(=O)C7"
}
|
Can you make molecule C[C@H]1CCC[C@H](NC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H]1CCC[C@H](NC(=O)CCC(C)(C)N2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
|
C[C@H]1CCC[C@H](NC(=O)CN2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
|
C[C@H]1CCC[C@H](NC(=O)CCC(C)(C)N2CCN(C(=O)N[C@@H](C)Cn3cncn3)CC2)C1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CCC&(C)C",
"old_substring": "C4(=O)C7"
}
|
Can you make molecule COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1cc(Br)c(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)n1
|
COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1
|
COCCn1cc(Br)c(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)n1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc(Br)c&n1",
"old_substring": "n17cc6cn1"
}
|
Can you make molecule COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1ccn(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)c1=S
|
COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1
|
COCCn1ccn(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)c1=S
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccn&c1=S",
"old_substring": "n17cc6cn1"
}
|
Can you make molecule COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1cc2cc(NC(=O)CSc3nc(C)c(C)c(C)c3C#N)ccc2n1
|
COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1
|
COCCn1cc2cc(NC(=O)CSc3nc(C)c(C)c(C)c3C#N)ccc2n1
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc2cc&ccc2n1",
"old_substring": "n17cc6cn1"
}
|
Can you make molecule COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)c2cccnc21
|
COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1
|
COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)c2cccnc21
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&cc&c2cccnc21",
"old_substring": "n17cc6cn1"
}
|
Can you make molecule COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCCn1ccc2nc(NC(=O)CSc3nc(C)c(C)c(C)c3C#N)ccc21
|
COCCn1cc(NC(=O)CSc2nc(C)c(C)c(C)c2C#N)cn1
|
COCCn1ccc2nc(NC(=O)CSc3nc(C)c(C)c(C)c3C#N)ccc21
| 102
|
{
"fragment_index": 0,
"new_substring": "n1&ccc2nc&ccc21",
"old_substring": "n17cc6cn1"
}
|
Can you make molecule C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nnnn1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nn2c(C3CC3)nnc2s1
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nnnn1C1CC1
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nn2c(C3CC3)nnc2s1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&nn2c&nnc2s1",
"old_substring": "c12nnnn14"
}
|
Can you make molecule C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nnnn1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1cc(C2CC2)nc2ncnn12
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nnnn1C1CC1
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1cc(C2CC2)nc2ncnn12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&nc2ncnn12",
"old_substring": "c12nnnn14"
}
|
Can you make molecule C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nnnn1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1cc(C2CC2)nn2cnnc12
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nnnn1C1CC1
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1cc(C2CC2)nn2cnnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&nn2cnnc12",
"old_substring": "c12nnnn14"
}
|
Can you make molecule C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nnnn1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1cc(C2CC2)nc2nncn12
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nnnn1C1CC1
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1cc(C2CC2)nc2nncn12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&nc2nncn12",
"old_substring": "c12nnnn14"
}
|
Can you make molecule C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nnnn1C1CC1 less soluble in water? The output molecule should be similar to the input molecule.
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1cc(C2CC2)cn2nnnc12
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1nnnn1C1CC1
|
C[C@H](c1ccc(F)c(F)c1)[S@+]([O-])Cc1cc(C2CC2)cn2nnnc12
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&cc&cn2nnnc12",
"old_substring": "c12nnnn14"
}
|
Can you make molecule COc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
|
COc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
|
COCc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COC&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
COCSc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
|
COc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
|
COCSc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "COCS&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CC(=O)Sc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
|
COc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
|
CC(=O)Sc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "CC(=O)S&",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CS)c1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
|
COc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
|
O=C(CS)c1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CS",
"old_substring": "CO5"
}
|
Can you make molecule COc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1 less soluble in water? The output molecule should be similar to the input molecule.
|
O=C(CI)c1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
|
COc1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
|
O=C(CI)c1ccc2cc(C[NH+]3CCC[C@H](Cn4ccnn4)C3)ccc2c1
| 102
|
{
"fragment_index": 0,
"new_substring": "C&(=O)CI",
"old_substring": "CO5"
}
|
Can you make molecule CSc1cccc(NC(=O)NCc2ccc(C)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSc1cccc(NC(=O)NCc2ccc(C)cc2Cl)c1
|
CSc1cccc(NC(=O)NCc2ccc(C)cc2)c1
|
CSc1cccc(NC(=O)NCc2ccc(C)cc2Cl)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(C)cc1Cl",
"old_substring": "c17ccc(C)cc1"
}
|
Can you make molecule CSc1cccc(NC(=O)NCc2ccc(C)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSc1cccc(NC(=O)NCc2ccc(Cl)cc2I)c1
|
CSc1cccc(NC(=O)NCc2ccc(C)cc2)c1
|
CSc1cccc(NC(=O)NCc2ccc(Cl)cc2I)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1I",
"old_substring": "c17ccc(C)cc1"
}
|
Can you make molecule CSc1cccc(NC(=O)NCc2ccc(C)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSc1cccc(NC(=O)NCc2ccc(Cl)cc2Br)c1
|
CSc1cccc(NC(=O)NCc2ccc(C)cc2)c1
|
CSc1cccc(NC(=O)NCc2ccc(Cl)cc2Br)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)cc1Br",
"old_substring": "c17ccc(C)cc1"
}
|
Can you make molecule CSc1cccc(NC(=O)NCc2ccc(C)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSc1cccc(NC(=O)NCc2cc(C)c(I)cc2C)c1
|
CSc1cccc(NC(=O)NCc2ccc(C)cc2)c1
|
CSc1cccc(NC(=O)NCc2cc(C)c(I)cc2C)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "Cc1cc&c(C)cc1I",
"old_substring": "c17ccc(C)cc1"
}
|
Can you make molecule CSc1cccc(NC(=O)NCc2ccc(C)cc2)c1 less soluble in water? The output molecule should be similar to the input molecule.
|
CSc1cccc(NC(=O)NCc2ccc(Cl)c(I)c2)c1
|
CSc1cccc(NC(=O)NCc2ccc(C)cc2)c1
|
CSc1cccc(NC(=O)NCc2ccc(Cl)c(I)c2)c1
| 102
|
{
"fragment_index": 0,
"new_substring": "c1&ccc(Cl)c(I)c1",
"old_substring": "c17ccc(C)cc1"
}
|
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