id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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5,915 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Patient with GERD resistant to medical treatment, or requiring daily long-term medical
treatment
Exclusion Criteria:
- Contraindications to the realization of a upper GI endoscopy
- Achalasia or other esophageal motor disorders
-... | Endoscopic Resection in Gastro-Esophageal Reflux Disease | NCT03357809 | Contradiction |
4,922 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
Patients diagnosed with ET and/or ET-plus by the Consensus Statement on the Classification
of Tremors, from the Task Force on Tremor of the International Parkinson and Movement
Disorder Society.
Exclusion Criteria:
Lack of capacity to consent to participate... | National Survey of Essential Tremor Plus in China | NCT04837079 | Entailment |
2,602 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Patients with primary bilateral inguinal hernias in patients aged from 20 to 60 years
Exclusion Criteria:
1. - Immune compromised patients,
2. - Morbid obesity (BMI > 35 kg/m2)
3. - Chronic liver or renal disease
4. - Coagulopathy
... | Laparoscopic Versus Open Repair of Bilateral Primary Inguinal Hernia | NCT04357665 | Contradiction |
6,632 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Healthy male and female subjects, 18-50 years of age, in good health as determined by
past medical history, physical examination, vital signs, electrocardiogram, and
laboratory tests at screening.
- Vital signs within the following parameters:
... | Safety, Tolerability and Pharmacokinetic Study of Single and Multiple Intravenous Doses of RSV604 in Healthy Subjects. | NCT00416442 | Contradiction |
1,596 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Between 20 and 75 years old.
- No significant upper extremity joint pain or nerve palsy.(patients with tennis elbow
typical of lateral elbow pain)
- Never received surgical treatment of upper limb joints
- No significant history of cardi... | An Intelligent Evaluation of Wrist Strength for the Elderly People and Its Clinical Application | NCT02190812 | Contradiction |
940 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Knee osteoarthritis
- Moderate radiographic evidence by Kellgren and Lawrence grade 2-4
- Knee pain > 20 on VAS pain scale
Exclusion Criteria:
- Bilateral knee replacements
- Unwillingness to take acetaminophen for pain relief
No... | Toward Better Outcomes in Osteoarthritis | NCT00000425 | Entailment |
2,911 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Clinical diagnosis of ALS classified as definite, or probable with or without
additional laboratory evidence, according to the revised World Federation of Neurology
(WFN) El Escorial criteria.
- If patients are being treated with riluzole, they mus... | A Safety Study of sNN0029 Administration Via Intracerebroventricular Route to Patients With ALS | NCT01999803 | Entailment |
1,042 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- ACR criteria for knee will be over age 50 less than 30 minutes of morning stiffness,
crepitus on active motion, Tenderness Enlargment No palpable warmth of synovium.
Osteoarthritis grade 1 and 2 by Kelly-green and Lawrence method.
Exclusion Criteria:
... | Mulligan Mobilization With Movement Versus Macquarie Injury Management Group in Function and Pain of Knee Osteoarthritis | NCT04818307 | Entailment |
110 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. History of TBI as defined as "damage to brain tissue caused by an external mechanical
force as evidenced by loss of consciousness or post traumatic amnesia (PTA) due to
brain trauma or by objective neurological findings that can be reasonably attributed
... | Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy | NCT01201863 | Contradiction |
3,853 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Female
2. Age 40-85 years
3. One or more of the following:
1. Knee symptoms (pain, aching, or stiffness) on most of the last 30 days;
categorically defined, so all severity of symptoms ok, but must have knee
symp... | Combined Application of Electrical Stimulation and Volitional Contractions for Muscle Strengthening and Knee Pain Inhibition (Seated Study) | NCT02802878 | Entailment |
290 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion criteria :
- Infertile patients associated with multiple implantation failures.
- Signatures consent and non-opposition letter.
- Patients with a standard infertility assessment.
- Patients with a monitored cycle (ultrasound, hormonal markers) during the mock fr... | Prospective Study of an Human Endometrial Receptivity Test | NCT04192396 | Contradiction |
1,386 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Patients eligible for enrollment will include all pediatric patients suffering from HD
at an age of 12 months or younger. All patients will require consent by either parent
or adult guardian
Exclusion Criteria:
- Patients will be excluded ... | Probiotic Prophylaxis of Hirschprung's Disease Associated Enterocolitis (HAEC) | NCT00630838 | Entailment |
5,121 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Men and women aged > 18 years who/se:
- Present at the ER with a possible hip fracture and
- Have a negative x-ray for a hip fracture
- Physician has a high clinical suspicion of a hip fracture
- Provide provision of informed consent
... | Tomosynthesis Use in Detecting Subtle Occult Hip Fractures | NCT02133794 | Contradiction |
6,045 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Confirmed symptom history of heartburn, acid regurgitation, or epigastric pain of at
least 3 months, while treating with gastric acid modulating therapy (antacids, H2
receptor antagonists (H2RAs) and/or PPIs).
- Heartburn symptoms that average 3 ti... | Pilot Study To Investigate The Association Between Acid Control And Heartburn Symptoms After Proton Pump Inhibitor Treatment | NCT02708355 | Entailment |
298 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Primary or secondary infertility designated for IUI treatment.
- Age of candidates: 20-40 years.
- Normal uterus x-ray.
- Women suffering from infertility on a background of non-ovulation.
- Infertility on a background of male problems (o... | Effects of Intra-uterine Slow-Release Insemination on Pregnancy Rate in Women Designated for Artificial Insemination | NCT00745563 | Contradiction |
5,547 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
1. A diagnosis of newly diagnosed or relapsing GCA. Diagnostic criteria for GCA
A patient will be said to have GCA by meeting 3 of 5 of the following modified ACR
criteria for the classification of GCA in which 1 of the 3 must consist of criteria 4
... | Abatacept for the Treatment of Giant Cell Arteritis | NCT04474847 | Entailment |
6,600 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Severe hemophilia A (FVIII:C </=1%)
- No history of FVIII inhibitor formation and no current evidence of inhibitor antibody
(Bethesda Assay < 0.6 BU)
- Elective major surgery requiring at least 6 days of rFVIII-FS therapy
- Subjects shou... | BAY14-2222 Continuous Infusion in Surgeries | NCT00606060 | Contradiction |
5,173 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- VCF on X-ray of the spine (minimal 15% loss of height)
- level of VCF Th5 or lower
- back pain ≥ 12 weeks at time of X-ray
- ≥ 50 years of age
- bone edema on MRI of the fractured vertebral body
- focal tenderness on VCF level... | A Trial of Vertebroplasty for Painful Chronic Osteoporotic Vertebral Fractures (Vertos V) | NCT01963039 | Entailment |
1,875 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- carcinoma located in the lower 1/3 of gastric body or antrum of stomach
- diagnosed by endoscopy ,endoscopic ultrasonography and abdominal CT scan
- diameter of the tumor <3cm
- no pyloric obstruction
Exclusion Criteria:
- diamet... | Comparison of Delta-Shaped and Billroth II After TLDG | NCT02372747 | Entailment |
1,477 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Patient has primary Type II hyperlipidemia or mixed dyslipidemia.
- If the patient is currently taking a lipid modifying medication other than Zocor &
he/she is willing to discontinue this medication
- LDL-C levels and/or non HDL-C levels above norm... | Evaluation of the Safety & Efficacy of a Combination of Niacin ER & Simvastatin in Patients With Dyslipidemia (OCEANS) | NCT00080275 | Entailment |
6,517 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients scheduled for dental extraction and treated with edoxaban, apixaban,
rivaroxaban or dabigatran
- Not having taken the direct oral anticoagulant on the day of the extraction
- Provision of signed and dated informed consent form
- ... | Tranexamic Acid To Reduce Bleeding in Patients Treated With New Oral Anticoagulants Undergoing Dental Extraction | NCT03413891 | Contradiction |
3,971 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Adult Chinese subjects, at age≥18, either gender, diagnosed with osteoarthritis of the
target knee and Kellgren-Lawrence (KL) classification Grade 1~3, as evidenced by X-ray
examination in the last 3 months (mild to moderate narrowing of joint space and / or
... | Clinical Study of Artz in the Treatment of Knee Osteoarthritis | NCT02826031 | Entailment |
4,354 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Volunteer subject, , willing to follow the protocol and able to read, comprehend and
sign the informed consent form,
- Age between 17 and 23 years
Exclusion Criteria:
- Vulnerability of the subject,
- Participation in another st... | The Incidence and Progression of Myopia: Cohort Study | NCT03244670 | Entailment |
3,506 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Age >=18 years
- Diagnosis of cirrhosis
- Admission to hospital
Exclusion Criteria:
- Age < 18 years
- Prior enrollment in study (i.e. readmission)
- Prisoner
- Pregnancy
- Prednisone or Hydroc... | Is Adrenal Insufficiency Under-diagnosed in Hospitalized Cirrhosis Patients? | NCT03368066 | Contradiction |
5,141 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Women who are 60 to 90 years of age may be eligible to participate
- Bone mineral density (BMD) T-Score at hip or spine must be less than -2.5
Exclusion Criteria:
- BMD T-Score at the hip or the spine of less than -4.0
- Patients with any se... | A Study to Evaluate Denosumab in the Treatment of Postmenopausal Osteoporosis | NCT00089791 | Contradiction |
804 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Hong Kong permanent residents aged on or above 50, both male and female;
- meet the Clinical Classification Criteria for Osteoarthritis of the Knee by history,
physical examination and radiographic findings (recommended by the American College of
R... | Sinew Acupuncture for Knee Osteoarthritis | NCT03099317 | Entailment |
578 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Pregnant patients with nonviable pregnancy document by ultrasound
- Gestation at or less than 13 weeks by ultrasound measurements
- Clinically stable as determined by provider
- Afebrile
- Hematocrit > 30
- Over 18 years of ag... | Misoprostol for Non-Viable Pregnancies | NCT00426491 | Entailment |
3,919 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria
- Has diagnosis of osteoarthritis of the knee (tibio-femoral joint) for >6 months based
on clinical and radiographic criteria;
- Has a diagnosis of American Rheumatology Association (ARA) functional Class I, II, or
III;
- The knee designat... | The Single Dose Pharmacokinetics of Two and Proof of Efficacy of One New Etoricoxib Gel Formulation in Participants With Osteoarthritis (MK-0663-168) | NCT01980940 | Entailment |
92 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- 18 years or over male patients;
- Absent or incomplete puberty development;
- Serum testosterone values below 3.47 nmol/L by low or normal serum LH and FSH
concentrations.
- at least two or more pituitary hormone deficiencies
... | Efficacy of Pulsatile GnRH Therapy on Male Patients With Pituitary Stalk Interruption Syndrome | NCT02705014 | Contradiction |
3,066 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
1. Intellectual disabilities (ID) group:
- children with mild to moderate intellectual disabilities.
- able to walk independently
- can follow simple commands
2. Typical developed children:
- age-matched TD chi... | Development and Application-Smart Football for Movement Evaluation and Training in the Special Education Population | NCT02486081 | Entailment |
4,154 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
Healthy volunteers
- Able and willing to give written informed consent.
- Healthy male and female subjects, aged 18-80 years for the initial part and 40-80
years for the main part, inclusive. Women will be considered for inclusion if they
ar... | Activation of Apoptosis-related Receptors on Alveolar Macrophages | NCT04775394 | Contradiction |
1,584 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- right handed adults
- no known physical or neurological abnormalities
Exclusion Criteria:
- patients with:
- cardiac pacemaker
- surgical clips or values on the heart
- implants
- metal or metallic fragmen... | Contribution of the Somatosensory System to Speech Perceptual Processing | NCT04818021 | Contradiction |
4,272 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Age: 25-35 years.
- trained male caucasian cyclists
- Non-smokers
- Each subject completed an approved informed consent form and detailed health
questionnaire before testing.
Exclusion Criteria:
- Smokers.
... | Feel Breathe, Restriction Device Ventilatory Nasal | NCT01608529 | Entailment |
78 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- T2DM
- male sex
- HbA1c >=7,5% -11%
- Age >=18 -75 years
- BMI>=30kg/m²
- Hypogonadism assessed by laboratory testing (testosterone < 3,5ng/ml (=12nmol/l)
- Metformin, SGLT2 inhibitors, DPP4 inhibitors and long act... | Effects of Testosterone Undecanoate vs Placebo on Intrahepatic Fat Content in Obese Men With T2DM and Hypogonadism | NCT03851627 | Contradiction |
2,199 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- diagnosis of gout based on the ACR/EULAR 2015 criteria
- uricemia ≥6 mg/dL
- warranted introduction of urate-lowering therapy according to the ACR 2012 or EULAR
2016 criteria
- signature of the informed consent
- social insur... | Study of the Correlation Between UltraSonography and Dual-Energy Computed Tomography Assessment of Urate Deposit | NCT03162341 | Contradiction |
2,203 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Subject is able to understand the study procedures, the risks involved and willing to
provide written informed consent before the first study related activity.
- Subject meets the diagnosis of gout as per the American Rheumatism Association
Criteri... | Combining Lesinurad With Allopurinol in Inadequate Responders | NCT01493531 | Contradiction |
6,353 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Work Stream A (in-hospital; Group 1 and Group 2):
Group 1 Inclusion Criteria:
We will include participants (patients or staff):
1. That are 18 years or older
2. That will require testing for COVID-19 in the opinion of the treating clinician
3. That may have presented w... | Facilitating AcceLerated Clinical Validation Of Novel Diagnostics for COVID-19 (FALCON-C19) | NCT04408170 | Entailment |
729 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
Subjects will include those for whom a discontinuation trial of NSAIDs is most appropriate:
1) Veterans with knee pain despite NSAID use and/or 2) Veterans at relatively higher risk
of NSAID toxicity 55-59 as ascertained by meeting 1 or more of the following 4 criteria:
... | Discontinuing NSAIDs in Veterans With Knee Osteoarthritis | NCT01799213 | Contradiction |
1,863 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Eligible criteria :
- Patient having endoscopic oesogastroduodenal endoscopy for suspicion of
oesogastro-duodenal adenocarcinoma.
- Benefiting from the social security system
Inclusion Criteria:
- Patient having endoscopy biopsies in front of a suspicious lesion... | Evaluation of the Reliability of the Determination of MisMatch Repair Deficiency Status by Endoscopic Biopsies in Oesophagus and Gastric Adenocarcinoma. | NCT04774367 | Entailment |
4,814 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Patients referred to an otorhinolaryngological university clinic due to suspected
vestibular disorders (dizziness)
- Patients must be bothered with dizziness at the time of consultation
Exclusion Criteria:
- Patients uable to fill in questi... | Musculoskeletal Pain in Long-term Dizziness | NCT04241822 | Entailment |
5,264 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Patients with established osteoporosis according to standard clinical criteria.
- Patients who give their written informed consent to participate in the study consent.
- Meet all the inclusion criteria
Exclusion Criteria:
- Patients with con... | Clinical Trial of Intravenous Infusion of Fucosylated Bone Marrow Mesenchyme Cells in Patients With Osteoporosis | NCT02566655 | Entailment |
5,374 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Have completed Study CSLCT-BIO-08-52 (Assessment of Efficacy and Safety of Biostate in
Paediatric Subjects with Von Willebrand Disease) or Study CSLCT-BIO-08-54 (Assessment
of Efficacy and Safety of Biostate in Adolescent or Adult Subjects with Von Willebrand
... | Extension Study of Biostate in Subjects With Von Willebrand Disease | NCT01224808 | Entailment |
4,642 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion criteria:
- - Adult patient
- Patient benefiting from the routine management of a programmed hysterectomy by
vaginal, laparoscopic or laparotomy for benign pathologies (fibroma, adenomyosis,
genital prolapse,...) within the CMCO
- Patient consentin... | Study Of The Metabolic Parameters Of Uterine Muscle Cells | NCT03784157 | Entailment |
2,212 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- from 18yrs to 80yrs , man and women
- the patient who are taking allopurinol
- On screening, the patient shows that the level of protein/creatinine ratio is over 3.0
- On screening, the patient shows that MDRD GFR >= 30 ml/min and <= 60 ml/min
... | A Pilot Study for Pharmacokinetic/Pharmacodynamic (PK/PD) Parameter of Allopurinol and Its Metabolite-oxypurinol After Once-daily Allopurinol in Chronic Kidney Disease Patient | NCT01145274 | Contradiction |
5,133 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal women, aged ≥ 55 to ≤ 90.
- Received oral bisphosphonate therapy for at least 3 years immediately prior to
screening
- BMD T-score ≤ -2.50 at the lumbar spine, total hip or femoral neck
- History of nonvertebral fracture a... | An Open-label Study to Evaluate the Effect of Treatment With Romosozumab or Teriparatide in Postmenopausal Women | NCT01796301 | Contradiction |
5,962 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Had a hiatal hernia repair with MIROMESH greater than 6 months prior to study
Exclusion Criteria:
- N/A
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH | NCT03735862 | Contradiction |
616 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women aged 18 years or older with an undesired pregnancy < 6 weeks gestation
- Women with a positive urine pregnancy test
- Proficiency in English
- Working phone and subject willing to be contacted by phone.
- Agreeing to surveys regardi... | The Role of a Semi-Quantitative Urine Pregnancy Test and Pregnancy Questionnaire After Uterine Evacuation for Undesired Pregnancy of Uncertain Location | NCT01596972 | Entailment |
3,587 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Healthy male and female subjects, aged 18 to 45 years.
- A body mass index (BMI, or Quetlet index) in the range of 18.0 to 30.0 kg/m2, and
weighing between 50 and 100 kg at screening.
- Male subjects have to agree to contraception (condom with sperm... | DS1040b/Aspirin Drug/Drug Interaction Study | NCT02071004 | Contradiction |
5,109 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- females 60 - 75 years old
- caucasian race
Exclusion Criteria:
- CHD-diseases
- thrombosis, embolism
- fractures at lumbar spine or hip
- secondary osteoporosis
- hyperparathyroidism
- medicati... | Effects of Whole Body Vibration on Postmenopausal Risk-factors in Elderly Women | NCT00667667 | Contradiction |
5,821 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Age over 18 years.
2. GERD symptoms lasting more than 6 months, not necessarily consecutive. They should at
least have a typical GERD symptom (heartburn or regurgitation).
3. Total acid exposure time> 6% in pH measurement study without PPI treatment.
... | Antireflux Ablation of the Cardia Mucosa vs Placebo for the Treatment of Gastroesophageal Reflux Disease | NCT04711655 | Contradiction |
3,814 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- those with medical diagnosis (providing written evidence from a physician, physician
assistant, or nurse practitioner) of knee OA unilaterally or bilaterally.
Exclusion Criteria:
- bilateral total knee arthroplasty, requirement of an assistive device o... | Effect of TA Contraction on Gait in Patients With Knee OA | NCT03513094 | Entailment |
370 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | - INCLUSION CRITERIA:
Healthy volunteers will be in excellent health.
Only women with regular menstrual cycles (every 26-35 days) using mechanical (condoms,
diaphragm) or sterilization methods of contraception will be included.
Only women with a negative pregnancy test, normal physic... | Hormonal Effects on the Uterus and Endometrium | NCT00001454 | Contradiction |
2,151 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Adults aged over 18 years old
- Gout confirmed by identification of urate crystals by joint fluid or tophus analysis
or by ultrasound of the affected joint or
- Gout according to Nijmegen criteria (presence of a score ≥ 8/13) depending on the
... | Anakinra vs Prednisone to Treat Gout Flare in Patients With Chronic Kidney Disease Stage 4/5 or Renal Transplantation | NCT04844814 | Contradiction |
1,757 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- No history of benign and malignant tumors (including carcinoma and adenoma) of upper
GI (including esophagus, stomach and duodenum)
- undergo gastroscopy with intravenous anesthesia (or conscious sedation)
Exclusion Criteria:
- Subjects wit... | Setting the Shortest Examination Time of Gastroscopy to Improve the Detection Rate of Upper Gastrointestinal Tumors | NCT04602299 | Contradiction |
6,383 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Any adult with the following:
- Symptoms compatible with COVID-19 disease (Fever >37.8oC on at least one occasion
AND either cough and/ or anosmia) within the first 5 days of symptom onset
- OR ANY symptoms compatible with COVID-19 di... | FLARE: Favipiravir +/- Lopinavir: A RCT of Early Antivirals | NCT04499677 | Entailment |
6,256 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Primary bariatric surgery;
2. Compensated DMT2;
3. Controlled hypertension;
4. Patients with OSAS can only be admitted if therapy with home CPAP is effective
5. Laparoscopic standard bariatric procedure;
6. Procedure duration less ... | Obesity Surgery During 2020 Italian Pandemic | NCT04480034 | Contradiction |
403 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women undergoing IVF/ICSI treatment with expected poor ovarian response according to
the Bologna criteria
Exclusion Criteria:
- Women with BMI >35 Kg/m2
- Women with a single ovary
- Known allergy to DHEA
- Diabetic ... | DHEA Versus Placebo in Women With Poor Ovarian Response | NCT02561793 | Contradiction |
3,413 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- chronic tympanic membrane perforation
- dry ear at least 4 weeks before the procedure
- no evidence of cholesteatoma
- hearing test in the last 3 months
- signing informed consent
Exclusion Criteria:
- age under 18 ye... | Repair of Tympanic Membrane Perforation Using Tachosil Under Local Anesthesia | NCT04428463 | Contradiction |
1,332 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
1. Height of at least 2.0 standard deviations below the mean height for chronological age
and sex according to the 2000 standards from the Centers for Disease Control and
Prevention (CDC).
2. Children that have one of the following short stature pathol... | Effects of Growth Hormone (GH) Treatment on Eating Regulation | NCT00562705 | Contradiction |
3,403 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Serous Otitis Media for More Then 3 months
- Conductive Hearing Loss of More Then 15 decibels.
- Tympanometry type B or C.
Exclusion Criteria:
- No History of Tympanostomy Tube Insertion or Adenoidectomy
- No Cranio or Facial Mal... | The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children | NCT00393159 | Contradiction |
3,127 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Women ages 18-35 years who live with their husbands or partners within the
pre-selected study clusters
- Consent from husband/partner as well as eligible woman
- Women in polygynous unions, if the wife co-resides with her husband
Exclusion ... | Promoting Female Empowerment at the Household Level Among Couples in Ibadan, Nigeria | NCT03888495 | Contradiction |
4,052 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Primary diagnosis of Functional Class I-III osteoarthritis (OA) of the hip or knee
- Chronic user of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or acetaminophen for
OA pain
- Discontinued all analgesic therapy at Screening
- For w... | Meloxicam SoluMatrix® Capsules vs Meloxicam Tablets to Treat Osteoarthritis Pain | NCT02405793 | Entailment |
4,701 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | INCLUSION CRITERIA:
General inclusion criteria:
Female gender--to evaluate effects in the target population for clinical trials.
In good health. Chronic medication use is acceptable except for glucocorticoid use. Other
chronic medication use may be acceptable at discretion of the prin... | Comparison of Blood Levels of Two Formulations of the Selective Hormone Receptor Modulator CDB-2914 | NCT00041899 | Entailment |
6,702 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
Control group and hepatically impaired groups:
- Male and/or female subjects between 18 and 65 years of age. Female subjects must be
surgically sterilized or postmenopausal (Postmenopausal women must have no regular
menstrual bleeding for at least 2 yea... | Effect of Moderate Hepatic Impairment on the Pharmacokinetics and Metabolism of a Single Dose of Licarbazepine | NCT00424671 | Contradiction |
4,353 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
1. Age from 7 to 17 years old or from 18 to 45 years old;
2. Meet the diagnostic criteria for patients with simple low or moderate myopia, with
diopter < -6.0d and eye axis < 26.0mm;
3. Transparent refractive stroma, no other eye diseases except nearsigh... | Effects of 650nm Low Energy Light on Human Retina and Choroid Microcirculation | NCT04604405 | Entailment |
3,709 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
Or at least two of criteria 2-6 established by the American College of Rheumatology (ACR):
1. Kellgren and Lawrence (K/L) grade ≥II
2. morning stiffness <30 min in duration
3. crepitus on movement of the knee joint
4. bony tenderness at the knee j... | The Effects of Joint Effusion on Proprioception | NCT01060215 | Contradiction |
3,315 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion:
- 2-6 years old
- complete ophthalmic examination including cycloplegic refraction conducted on the same
day or within 3 months
- strabismic, anisometropic, or normal (normal eye examination and refractive error
according to AAPOS guidelines)
... | Amblyopia and Strabismus Detection Using a Pediatric Vision Scanner | NCT01726842 | Entailment |
4,685 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women, diagnosed with benign gynecologic conditions, undergoing open abdominal surgery
Exclusion Criteria:
- Surgeries performed for cancer
- Intraoperative accidental injury to urinary or gastrointestinal organs
- Postoperative admission to... | Elastic Abdominal Binder After Open Abdominal Surgery for Benign Gynecologic Conditions | NCT03820115 | Entailment |
3,858 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Adult male and female in-patients with vital signs considered 'stable' by clinical
caregivers.
Exclusion Criteria:
- Pediatric patients
- Female patients who are pregnant
- Patients with internal or external defibrillators
... | Vital Signs Patch Early Feasibility and Usability Study | NCT02521922 | Entailment |
2,801 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Patients with Primary Ventral or Incisional Hernias
- Scheduled to undergo hernia repair through an open approach
- Hernia repair performed in an elective setting
- Hernia repair performed through a midline incision
- Hernia repair perfor... | Exparel vs. Bupivacaine Hydrochloride vs. Placebo for Hernia Repair | NCT03541941 | Entailment |
1,809 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Subjects showing at least one of the 4 symptoms (upper abdominal pain, upper abdominal
discomfort, epigastric pain, epigastric burning) for at least 6 months before
obtaining informed consent
- Subjects showing two or more of the following symptoms... | To Verify the Efficacy of Z-338 in Subjects With Functional Dyspepsia | NCT00761358 | Contradiction |
4,786 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Adult males/females, 18-75 years of age at the time of enrollment.
- Diagnosis of definite Meniere's Disease by AAO-HNS Amended 2015 Criteria.
- Hearing loss of ≥30 dB at 250, 500, or 1000 Hz at study enrollment.
- At least two of three active sympto... | SPI-1005 for the Treatment of Meniere's Disease | NCT04677972 | Entailment |
6,239 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Have given informed consent by signing the informed consent form (ICF) before
initiation of any trial-specific procedures.
- They must be willing and able to comply with scheduled visits, treatment schedule,
laboratory tests, lifestyle restrictions... | A Trial Investigating the Safety and Effects of One BNT162 Vaccine Against COVID-19 in Healthy Adults | NCT04537949 | Contradiction |
6,368 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- the patient has a recent mild or moderate COVID-19 with no or low-grade fever 99.5-
100.94 °F (37.5-38.3 °C). Mild COVID-19 included that the patient has symptoms of
acute upper respiratory tract infection (fever, cough, myalgia, runny nose, fatigue,
... | The Effect of Aerobic Exercise on Immune Biomarkers and Symptoms Severity and Progression in Patients With COVID-19: A Pilot Randomized Control Trial | NCT04581291 | Entailment |
485 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Female subjects of childbearing age, who are being screened for pregnancy and who have
signed the informed consent
Exclusion Criteria:
- Subject is post-menopausal.
- Subject within the past six weeks has experienced any of the following: d... | Sofia hCG FIA Field Study | NCT01803113 | Contradiction |
1,705 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion criteria:
1. Between the ages of 15-49 years;
2. Consent to participation;
3. Resident of at least 6 months in study community;
4. Enrollment into RCCS at baseline (2005-06);
5. Report of sexual activity or being in a partnership in the year prior to the ... | Assessing the Impact of an Intervention to Prevent Intimate Partner Violence and HIV in Uganda | NCT02050763 | Entailment |
2,574 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Male and female children aged 2 - 8 years
- physical status classification system (ASA) score I or II
- Undergoing surgical interventions in the groin (hernia repair, funiculocele ectomy)
Exclusion Criteria:
- Hypersensitivity to Levobupivac... | Transversus Abdominis Plane Block for Pain Relieve in Children Undergoing Groin Surgery | NCT00970086 | Contradiction |
4,596 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
Healthy women who meet the following criteria:
- Aged 18-<40 years who wish to use a combined hormonal contraceptive.
- Women not intending to become pregnant for 13 months.
- Intact uterus and both ovaries.
- Prior history of regular menstrua... | Safety and Efficacy of a Contraceptive Vaginal Ring Delivering Nestorone® and Ethinyl Estradiol | NCT00263341 | Contradiction |
1,341 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- a diagnosis of achondroplasia or hypochondroplasia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Months old.
| C-Type Natriuretic Peptide and Achondroplasia | NCT01541306 | Entailment |
5,855 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Male and female patients over the age of 18 years.
- Women in the follicular phase of the menstrual cycle (visits will be arranged so that
in menstruating women, the study will be started in the follicular phase of the
menstrual cycle to standardis... | The Effect of Autonomic Modulation on Symptoms in Patients With Reflux Hypersensitivity | NCT04253444 | Contradiction |
2,548 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Male and female children aged ≥6 months to ≤6 years
- Baseline PEST score of 3- 4
- Diagnosis of mild to moderate atopic dermatitis, with grading of 3 to11, as per the
NESS
- Diagnosis of current flare (increased dryness, itching, rednes... | Correlation Study Between PEST and SCORAD in Management of Atopic Dermatitis With Ceradan® Regimen | NCT02073591 | Entailment |
1,351 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Patients and their families with known or suspected genetic disorders within the following
categories will be recruited:
Hereditary connective tissue disorders;
Phacomatoses;
Chromosomal disorders;
Dysmorphic syndromes;
Neuromuscular or neurological disorders;
... | Study of Clinical and Molecular Manifestations of Genetic Disorders | NCT00001466 | Entailment |
508 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Willing and able to use OCs or DMPA
- General good health (by volunteer history and investigator assessment) without any
clinically significant systemic disease
- Currently having regular menstrual cycles of 25 to 35 days by volunteer report
... | Contraception and Menstrual Cycle Effect on Pharmacokinetics, Pharmacodynamics and Safety in Tenofovir Vaginal Gel Use | NCT01421368 | Contradiction |
1,108 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | No eligibility criteria
Male
No healthy subjects accepted to join the trial.
Subject must be at most 100 Years | Identifying High Risk Patients With Syncope | NCT00005202 | Entailment |
2,890 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Clinical diagnosis of laboratory-supported probable, probable, or definite ALS
according to EI Escorial diagnostic criteria
- Age: 18-70 years
Exclusion Criteria:
- Refuse to cooperate or reject the informed consent
No condition on gender t... | Registration Study of Amyotrophic Lateral Sclerosis (ALS) in Mainland China | NCT04328675 | Entailment |
1,678 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- patients with common hand conditions
Exclusion Criteria:
-
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Question Prompt List for Common Hand Conditions | NCT03868449 | Entailment |
2,527 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Pediatric subjects aged ≥ 2 to 17 years, inclusive
- Subjects diagnosed with AD as defined by the Hanifin and Rajka criteria.
- Subjects with active inflammation associated with AD.
- Subjects with an Investigator's Global Assessment (IGA) score of a... | A Pharmacokinetic Study of Ruxolitinib Phosphate Cream in Pediatric Subjects With Atopic Dermatitis | NCT03257644 | Entailment |
5,944 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- willingness to participate (based on the signed informed consent form);
- presence of gastroesophageal reflux disease, based on the following: a) typical
symptoms, like heartburn and/or regurgitation (for primary selection, symptoms should
be prese... | Real-life Study of Changes of Gastroesophageal Reflux Disease Manifestations Due to Behavioural and Diet Adherence | NCT04255693 | Contradiction |
2,374 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Patients 8 - 16 years of age at time of enrolment
- Male
- Presence of cardiac involvement/dysfunction, defined by abnormal peak systolic strain
in left ventricle (LV) inferolateral wall
- Confirmed diagnosis of DMD (out of frame dystrop... | Efficacy and Tolerability of Idebenone in Boys With Cardiac Dysfunction Associated With Duchenne Muscular Dystrophy | NCT00654784 | Entailment |
2,907 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Subject has the ability to understand the purpose and risks of the study and provide a
signed and dated informed consent and authorization to collect and use protected
health information (PHI) in accordance with national and local subject privacy
... | Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Amyotrophic Lateral Sclerosis (ALS) | NCT02478450 | Entailment |
1,381 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
Hirschsprung Disease, surgery
Exclusion Criteria:
-
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at most 18 Years | Registry for Hirschsprung Disease of the BELAPS | NCT04622410 | Entailment |
4,740 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- all patient presented by thyroid nodules either discovered clinically or incidentally.
Exclusion Criteria:
- no
No condition on gender to be admitted to the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years | Clinical Diagnostic Approach for Cases of Thyroid Nodules | NCT03884140 | Contradiction |
5,220 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Female: 50 years of age or older
- >5 years since last menses natural or surgical
- have lumbar spine or total hip BMD more that 2.5 SD below the young adult mean, or
have lumbar spine or total hip BMD more than 2.0 SD below the young adult female m... | A Study of a 35 mg Delayed Release Formulation of Risedronate for Osteoporosis | NCT00541658 | Entailment |
4,744 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- 18 years of age or older with the ability to provide informed consent
- English as the primary language
- Medically and psychologically suitable
- Willing to receive/have received meningitis vaccinations
- Able to pay for all care receive... | Cochlear Implantation for Treatment of Single-sided Deafness | NCT02532972 | Contradiction |
3,590 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
1. When subject signs the informed contest, 18≤ age ≤ 40, Male or female;
2. Body weight: male ≥50 kg, female ≥45 kg. Body mass index (BMI) of 19.0 to 26.0 kg/m²,
inclusive;
3. Subject's with normal or or abnormity without clinical significance judged by... | Phase I Study of Direct Coagulation Factor Xa Inhibitor SYHA136 Tablets in Chinese Healthy Volunteers | NCT04036656 | Contradiction |
2,077 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
prior asbestos exposure at least 20 years ago and/or documented pleural plaques (chest
x-ray evidence)
Resident of Ontario, Canada
Exclusion Criteria:
prior cancer (except non-melanotic skin cancer)
No condition on gender to be admitted to the trial.
Accep... | Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers | NCT00188890 | Entailment |
4,211 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- 30 Moderate COPD (GOLD classification) , AGE 45-70, both sexes.
- Treated with inhaled steroids and long acting beta agonists.
Exclusion Criteria:
- Active ischemic heart disease, heart failure, orthopedic problems that preclude
ergometric ... | The Effect of N-Acetylcystein on Quality of Life and Air Trapping During Rest and After Exercise | NCT00476736 | Contradiction |
4,239 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Patients with non-obstructive Azoospermia
- Patients between 25 - 60 years old.
Exclusion Criteria:
- Patients with obstructive Azoospermia
- Men with previous surgery in testis
- Men with infectious genital diseases and anatomic... | Testicular Injection of Autologous Stem Cells for Treatment of Patients With Azoospermia | NCT02041910 | Contradiction |
6,537 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. Male adults or children > 4 months of age.
2. Severe hemophilia A (FVIII < 0.01 U/ml).
3. Current or past high-responding inhibitor, anti-FVIII >= 5.0 B.U., ITI-refractory or
ITI-naive.
Exclusion Criteria:
1. Acquired hemophilia or... | The Hemophilia Inhibitor Eradication Trial | NCT04303572 | Contradiction |
58 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Has total serum testosterone (ST) levels less than 300 ng/dL at Screening.
2. Has a body mass index (BMI) between 20.0 and 40.0 kg/m^2, inclusive at Screening.
3. A male participant who is nonsterilized and sexually active with a female partner of
chi... | Effects of TAK-448 in Middle-aged and Older Men With Low Testosterone | NCT02381288 | Contradiction |
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