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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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944 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Male or female patient, older than 40 years of age, with knee osteoarthritis, based on
clinical and radiological criteria (Kellgren-Lawrence grade 2 - 3), as specified:
1. Pain on movement of the affected knee for more than 15 days in the previous month
... | Efficacy and Safety of Glucosamine Sulfate and Chondroitin Sulfate Combination in Treatment of Knee Osteoarthritis | NCT02010918 | Entailment |
3,576 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | Inclusion Criteria:
- solitary erythema migrans in patients > 15 years
Exclusion Criteria:
- a history of Lyme borreliosis in the past
- pregnancy or lactation
- immunocompromised status
- serious adverse event to doxycycline
- taking anti... | Duration of Antibiotic Treatment of Erythema Migrans | NCT00910715 | Entailment |
3,915 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- History of osteoarthritis (OA) of the knee joint and meeting American College of
Rheumatology (ACR) Clinical and Radiographic criteria,
- Currently taking nonsteroidal anti-inflammatory drugs (NSAIDs) and still experiencing
pain as per the protocol... | A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee | NCT01444365 | Entailment |
1,434 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Age: 40 to 70 years old.
- Untreated patients or those on monotherapy of antihypertensive drugs but with
uncontrolled blood pressure in the ranges of 140-160/90-100 mmHg.
- Patients on antihypertensive medication should discontinue their antihyperte... | Amlodipine Prevents Morning Blood Pressure Surge Study | NCT01030081 | Contradiction |
5,458 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
1. Regularly menstruating women before CIUD insertion.
2. Age between 18 and 35 years.
3. Hormonal treatment has not been taken at least two months before the study.
4. Non steroidal anti-inflammatory drugs has not been taken 24 hours before the
... | Study About Patients Using Copper Intrauterine Device | NCT01541241 | Entailment |
3,503 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Healthy volunteers
Exclusion Criteria:
- Know history of pituitary or adrenal disease. Current or recent use of glucocorticoids,
and use of oral estrogen, pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at ... | Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers | NCT03752190 | Contradiction |
3,421 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Subject is informed and has been given ample time and opportunity to think about
his/her participation and has given his/her written informed consent
2. Subject is ≥18 years of age
3. Subject's health status: individual is considered to be healthy (hy... | A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application | NCT03998098 | Entailment |
2,171 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Male or female patients, age between 18 to 60 years
- With the data of serum uric acid level more than 8.0 mg/dl within 2 weeks before the
initiation of study
- Signed informed consent obtained prior to inclusion into the study
Exclusion Cr... | A Clinical Double Blind, Randomized Study of the Efficacy of Hyperuricemia Treatment With Anserine Product. | NCT00208000 | Contradiction |
2,246 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Acute gouty arthritis meeting the American College of Rheumatology (ACR) criteria for
acute arthritis of primary gout;
- Onset of pain from an acute gouty arthritis attack within 48 hours prior to
Screening/Baseline (Visit 1);
- A ratin... | Celebrex In Acute Gouty Arthritis Study | NCT00549549 | Entailment |
4,715 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Volunteer,
- Between the Ages of 18-45,
- Least Primary School Graduate,
- Not Using Drugs That May Affect Cognitive Functions,
- Non-Alcohol Substance Use,
- Patients Without Psychiatric and Neurological Disease.
-... | Mü-opioid Receptor Level and Postoperative Pain in Patients With Gynecological Laparoscopy | NCT04690491 | Entailment |
6,554 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion criteria:
1. Male and aged 18 to 80 years old
2. Patients who were enrolled and treated in one of the following clinical trials:
- AGT4HB (EudraCT No 2005-005711-17) - FIX AAV gene therapy trial (Sponsor: St Jude
Children's Research Hospital)
... | Liver Biopsy In Haemophilia Gene Therapy | NCT04817462 | Contradiction |
3,502 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Primary adrenal insufficiency under stable glucocorticoid replacement therapy (15-30
mg of Hydrocortisone stable dose the last 3 months) due to autoimmune adrenalitis
(disease diagnosed at least 12 months before inclusion), age 20-60 years, BMI 20-30
... | Biomarker(s) for Glucocorticoids | NCT02152553 | Contradiction |
6,187 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Ages 18-65, Male or Female
- Normal exercise tolerance without dyspnea or clinically important limitation of
exercise tolerance.
Exclusion Criteria:
- Complicated heart or lung disease
- Pregnancy
- Complex arrhythmi... | The Effects of Filter During CPET on WOB and Aerosol Particle Concentrations | NCT04526925 | Contradiction |
6,800 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Hemophilia A
- Able and willing to comply with pharmacokinetic testing schedule
- Either overweight or obese BMI using CDC definitions by age
Exclusion Criteria:
- Inhibitor of > 0.6 BU twice in the past, or documented abnormal recovery of l... | Comparison of Ideal vs. Actual Weight Base Factor Dosing | NCT03286153 | Entailment |
661 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Male patients aged from 18 to 70 years
- Hepatic iron overload measured by magnetic resonance imaging [MRI] (> 36 µmol/g and <
200 µmol/L)
- Homozygosity for the C282Y mutation of the HFE or dysmetabolic iron overload syndrome
(DIOS) ba... | Cytochrome P450 2E1 and Iron Overload | NCT00138684 | Contradiction |
3,841 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Age 45-75 years old, male or female;
2. Single / bilateral knee pain, duration of more than 6 months;
3. KL (Kellgren-Lawrence) grade Ⅱ or Ⅲ in recent 6 months;
4. NRS ≥ 40mm;
5. Signed informed consent
Exclusion Criteria:
... | Electro-acupuncture in Knee Osteoarthritis | NCT03359603 | Entailment |
2,288 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Age 10-18 years
- Non-ambulatory (primary mode of transportation is via wheelchair for 3 years or less)
- Confirmed DMD diagnosis
- Steroid-naive for the 6 months prior to screening
- Stable dose of b-blocker or ACE inhibitor medication f... | CoQ10 and Prednisone in Non-Ambulatory DMD | NCT00308113 | Contradiction |
7,001 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Diagnosis of early-onset Alzheimer's disease based on the NIA-AA diagnostic criteria
as determined by the clinician. (Those patients with severe dementia due to
Alzheimer's disease or who have impaired decisional capacity, may participate only if
... | Early Onset Alzheimer's Disease Genomic Study | NCT03645993 | Entailment |
1,167 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- To have a diagnosis of lung cancer
- Complete chemotherapy
- Complete radiotherapy
- Coopere,
- Accepts participation in the study will be included in the study
Exclusion Criteria:
- Neurological, cognitive or orthope... | Multidimensional Evaluation Of Daily Living Activities And Quality Of Life In Lung Cancer Patients | NCT03881046 | Contradiction |
359 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- (1) Less than 6mm endometrial thickness before, (2) at least two failed implantations
before
Exclusion Criteria:
- Abnormal uterine cavity in Hysteroscopy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Sub... | HCG (Human Chorionic Gonadotropin) Priming for Thin Endometrium in IVF (in Vitro Fertilization) | NCT01768247 | Contradiction |
2,846 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Definite/probable ALS according to El Escorial criteria
- Aged > 40, < 85 years
- Progression from onset
- Disease duration ≤3 years
- Treatment with Riluzole
Exclusion Criteria:
- Rapid disease progression in the fir... | Growth Hormone in Amyotrophic Lateral Sclerosis | NCT00635960 | Entailment |
3,748 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Community-dwelling older adults aged 65 years and above with primary knee OA diagnosed
according to the ACR criteria for diagnosis of primary OA of the knee
Exclusion Criteria:
- Any inflammatory or serious medical condition
No condition on gender to b... | Prednisolone for Pain Reduction in Knee OA | NCT01619163 | Contradiction |
2,140 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion criteria:
- Confirmed diagnosis of gouty arthritis History of ≥ 3 gouty arthritis flares within
the previous 12 months
- Confirmed diagnosis/ documented history of chronic kidney disease (CKD) Stages 3or4
- Onset of current acute gouty arthritis flare within 3 ... | Canakinumab in the Treatment of Gouty Arthritis Flare(s) and Prevention of New Flares in Patients With Chronic Kidney Disease | NCT01593527 | Contradiction |
396 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women undergoing embryo transfer in either fresh or frozen cycles.
- Women whose endometrial cavity can be visualised adequately via US
Exclusion Criteria:
- Women aged >42 years
- Women whose endometrial cavity cannot be visualised adequate... | Three-dimensional Versus Two-dimensional Ultrasound Guided Embryo Transfer in Women Undergoing ART Treatment | NCT02413697 | Contradiction |
973 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Diagnosed with mild to moderate osteoarthritis based on Kellgren-Lawrence radiographic
classification
- Has a history of joint swelling, pain, stiffness, altered gait and loss of motion due
to degenerative cartilage
Exclusion Criteria:
... | Intra-Articular Autologous Bone Marrow Mesenchymal Stem Cells Transplantation to Treat Mild to Moderate Osteoarthritis | NCT01459640 | Entailment |
5,408 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- the patients who had undergone tooth extraction within the previous 3 months
Exclusion Criteria:
- those who required bone augmentation simultaneously with implant insertion, and
patients with any systemic disease
No condition on gender to be admitted ... | Evaluation of the Related Factors Influencing the Stability of Dental Implants | NCT02733861 | Entailment |
4,760 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Subject with conductive hearing loss or mixed hearing loss in the ear to be implanted.
Bone conduction thresholds with pure tone average (PTA4; mean of 0.5, 1, 2 and 4 kHz)
of ≤ 55 dB sensorineural hearing loss.
OR Subject with single-sided sensorineu... | Clinical Performance, Safety and Patient Reported Outcomes of an Active Osseointegrated Steady-State Implant System | NCT04041700 | Entailment |
6,769 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients with severe or moderately severe hemophilia A (HA) who have since birth been
treated with only a single Factor VIII product (i.e., FVIII protein molecules
containing only one primary amino acid sequence).
Exclusion Criteria:
- HA ... | Personalized Prediction of Tolerance and Immunogenicity in Hemophilia | NCT01626105 | Entailment |
1,892 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Histological diagnosis of gastric adenocarcinoma;
- Early stage GC without lymph node and distal metastasis;
- Availability of frozen, fresh GC and corresponding surgical margin samples;
- Available of methylation status of gene CpG island in the ext... | DNA Methylation Biomarkers and Metastasis of Gastric Carcinoma | NCT02159339 | Entailment |
1,387 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Patients from 0 to 16 years ;
- With rectosigmoid Hirschsprung's disease confirmed by rectal biopsies and at surgery;
- Already operated on, whatever the surgical technique was ;
- With a health care insurance;
- Clear information and sig... | MICROPRUNG : Intestinal Microbiota Analysis in Patients With or Without Hirschsprung's Associated EnteroColitis | NCT02857205 | Entailment |
6,900 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
1. Willingness to participate, as indicated by written informed consent of the patient.
The competence of the participating patient has to be assessed by a physician who is
not involved in this trial.
2. Male or postmenopausal female outpatients.
... | The Efficacy of a Combination Regimen in Patients With Mild to Moderate Probable Alzheimer's Disease | NCT01921972 | Entailment |
2,684 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Clinical diagnose of a primary groin hernia that requires surgical intervention.
- Eligible for procedure performed under general anesthesia
Exclusion Criteria:
- Not able to understand Danish, written and spoken.
- Emergency procedures
... | Onstep Versus Lichtenstein, the Onli Trial. | NCT01753219 | Entailment |
1,635 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | General: Age equal to or greater than 18.
Access to a primary medical care provider outside of the NIH.
Able to give informed consent.
No history of malignancy or autoimmune disease such as rheumatoid arthritis, vasculitis,
pyoderma gangrenosum, psoriasis.
No use of systemic ... | Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals | NCT00001760 | Entailment |
1,741 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- healthy subjects
- sporadic cigarette smoking (<9 cigarettes per month)
Exclusion Criteria:
- Any form of cardiovascular disease
- Any form of pulmonary disease like asthma or COPD
- Any form of systemic or chronic disorder like ... | Effects of E-smoke on Levels of Endothelial Progenitor Cells and Microparticles in Healthy Volunteers | NCT02532894 | Entailment |
2,428 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- (1)patients with diagnosed sarcoidosis, the skin pathology showed non necrotic
granuloma and negative staining of fungi and atypical mycobacterium; (2)No
corticosteroids and immunosuppressants were used for nearly 1 months.
Exclusion Criteria:
... | A Clinical Study of Tranilast in the Treatment of Sarcoidosis | NCT03528070 | Contradiction |
208 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Low T males 18 - 80 years of age
Exclusion Criteria:
- Normal T levels
- Elevated Prostatic Specific Antigen (PSA)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years | Testosterone Treatment for Hypogonadal Men | NCT00433199 | Entailment |
5,698 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Must be able to donate at least 10 mL of whole blood
- Must be able to provide consent, or parental consent and patient assent (if
applicable)
- Must be currently followed as a patient of a genetic clinic or counselor at one of the
recr... | Reproducibility of the Array-Based Comparative Genomic Hybridization (aCGH) System Using Whole Blood Samples | NCT00214448 | Entailment |
3,433 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- adults 18-50 years of age
- have unilateral or bilateral holes in the eardrums/patent tympanostomy tubes
- otherwise healthy
- ability to read and comprehend English
Exclusion Criteria:
- drainage through either tube or hole in t... | Gas Supply, Demand and Middle Ear Gas Balance -- Preliminary Protocol | NCT01955486 | Entailment |
5,861 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Male and female GERD patients aged 18-70 years with GERD symptoms.
- Prior long-term treatment with PPI with minimum duration of 1 year with expected
future duration of at least 2 more years.
- Controlled on 20-40mg/day maintenance PPI therapy prior... | A Randomized Controlled Trial of Laparoscopic Nissen Fundoplication Treatment of Patients With Chronic GERD | NCT00182260 | Contradiction |
1,737 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- ASA-Status 1
- Complete permanent dentition
- Bitewing radiography already existing (< 4 months)
- Minimum of one cavitation-free approximal surface, symptomless, interproximal enamel
or dentin caries lesion in the posterior teeth withou... | Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection | NCT02657538 | Entailment |
4,074 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- Idiopathic REM sleep behavior disorder
Exclusion Criteria:
- REM sleep behavior disorder secondary to another cause (ex: narcolepsy, dementia,
Parkinson's Disease, etc)
- Other neurological disorder
No condition on gender to be admitted to ... | North American Prodromal Synucleinopathy Consortium | NCT03623672 | Contradiction |
1,307 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- adult medical or surgical ICU patients who have preexisting central venous
(jugular/subclavian only) catheters.
Exclusion Criteria:
- subjects with only a femoral venous catheter.
- subjects whose CVP measurement by the indwelling catheter ... | Central Venous Pressure (CVP) Assessment by Ultrasound and Physical Examination | NCT01099241 | Contradiction |
807 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Patients ≥40 and ≤ 80years of age.
2. Patients who meet the American College of Rheumatology clinical plus radiographic
classification criteria for idiopathic osteoarthritis of the knee, which are defined
as follow:
a patient who had k... | Active Drug Comparative, Multi-center, phase3 Clinical Study to Evaluate the Efficacy and Safety of PG201 in Osteoarthritis Patients | NCT01576419 | Entailment |
527 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- women age < 45years
- BMI < 35 kg/m2
- at least one of good quality embryo in embryo transfer cycle by Istanbul consensus
workshop morphologic grading Day3 : Grade 1-2, Day4 : Grade 1-2 , Day5 : stage of
development grade 2-4
E... | Comparison of Uterine Peristaltic Wave Frequencies Between Pregnant and Non-pregnant Women in Embryo Transfer Cycles | NCT03587246 | Contradiction |
5,616 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
1. Pre-pubertal child aged ≥ 3 years old, and not yet 10 years for girls (9 years and 364
days) or not yet 11 years for boys (10 years and 364 days), on the date of ICF
signature, with either isolated GHD, or GH insufficiency as part of multiple pituitary
... | Safety and Efficacy Study of MOD-4023 to Treat Children With Growth Hormone Deficiency | NCT03874013 | Contradiction |
2,552 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
1. Children with a diagnosis of atopic dermatitis that meet Hanifin and Rajka criteria
2. SCORAD ( SCORing Atopic Dermatitis) index 15- 50 at the time of enrollment
Exclusion Criteria:
1. SCORAD (SCORing Atopic Dermatitis) index <15 or >50.
2. Chi... | Efficacy of Oral Supplementation of Probiotics in Children With Atopic Dermatitis | NCT04706559 | Entailment |
1,470 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Osteoarthritis of the hand, hip, knee or spine
- High blood pressure (<140/ 90 mmHg) which is controlled by antihypertensive
medication(s).
Exclusion criteria
• Evidence or history of any cardiac and cerebral thrombotic/ ischemic diseases and/... | Safety and Efficacy of Lumiracoxib in Patients With Osteoarthritis and With Controlled Hypertension | NCT00267176 | Entailment |
2,488 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- Healthy female subjects of non childbearing potential and male subjects.
- Body Mass Index (BMI) of 17.5 to 30.5 kg/m2 (32 kg/m2 for healthy elderly); and a
total body weight >50 kg (110 lbs) at Screening.
- Evidence of a personally signed and dated... | Clinical Trial In Healthy Volunteers And Health Elderly Volunteers To Evaluate The Safety, Tolerability And Blood Concentration After Single And Multiple Escalating Oral Doses Of PF-06751979. | NCT02793232 | Entailment |
5,485 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria: for the cohort study
1. A clinical suspicion of new diagnosis of GCA e.g. patients with a new onset of
headache, scalp tenderness, with or without elevated CRP or ESR, jaw or tongue
claudication with or without visual loss.
2. The clinician decides tha... | Temporal Artery Biopsy vs ULtrasound in Diagnosis of GCA (TABUL) | NCT00974883 | Contradiction |
5,808 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- All patients over 18 years old
- All non pregnant women
Exclusion Criteria:
-
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
| Comparison of Triamcinolone Acetonide Mucoadhesive Film and Licorice Mucoadhesive Film Effect on Lichen Planus | NCT02453503 | Entailment |
4,675 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Patients receive laparoscopic-assisted vaginal hysterectomy (LAVH)
- American Society of Anesthesiologists (ASA) physical status of patient: classification
I-II
Exclusion Criteria:
- The procedure will be required to conversion to laparotom... | Single-port Access Laparoscopic-assisted Vaginal Hysterectomy | NCT01048931 | Entailment |
2,671 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- patients scheduled for laparoscopic primary inguinal hernia repair
- uni- or bilateral patients with recurrent hernias after anterior surgical technique
- written informed consent
Exclusion Criteria:
- general contradictions for laparoscopy
... | Stapler Versus Glue for Laparoscopic Groin Hernia Repair | NCT00793286 | Entailment |
2,946 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Key Inclusion Criteria:
- Diagnosis of clinically possible, clinically probable (with or without laboratory
support), or clinically definite ALS (using the revised El Escorial Criteria)
- Forced vital capacity greater than or equal to 65% of that predicted for age and
h... | Safety and Efficacy Study of NP001 in Patients With Amyotrophic Lateral Sclerosis (ALS) and Systemic Inflammation | NCT02794857 | Entailment |
2,063 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | - INCLUSION CRITERIA:
Individuals who are 18 years of age or older with any of the following:
1. Idiopathic pulmonary fibrosis [defined by the American Thoracic Society/European
Respiratory Society guidelines],
2. Familial pulmonary fibrosis [defined as idiopathic pulmonary ... | Analysis of Specimens From Individuals With Pulmonary Fibrosis | NCT00084305 | Entailment |
3,226 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion criteria:
1. Positive diagnosis of Sjogrens syndrome, defined by meeting two or more of the
following three criteria:
- Positive serum anti-SS-A/Ro and/or anti-SS-B/La (or positive rheumatoid factor
and ANA ≥ 1:320)
- Labial salivary ... | Fecal Microbial Transplant (FMT) for Sjogrens Syndrome | NCT03926286 | Entailment |
2,040 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients with radically resected adenocarcinoma of the stomach and/or gastroesophageal
junction with histologic proof of adenocarcinoma, pathologically staged T2-3, any N,
M0
- No prior radiation therapy to the stomach or immunotherapy or chemother... | Postoperative Chemotherapy and Chemo-radiotherapy for Resected Gastric Cancer | NCT00718913 | Entailment |
4,226 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- age 20-50 years
- idiopathic male factor infertility for at least one year;
- homozygous FSHR allele at codon 680 (wild type: Asn/Asn or Ser/Ser);
- sperm DFI > 15%;
- normal serum FSH levels (< 8 IU/L)
- normal serum LH, test... | FSH Receptor Polymorphism p.N680S and Efficacy of FSH Therapy | NCT02349945 | Contradiction |
2,633 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Primary, unilateral or bilateral, inguinal hernia patients
- Informed consent
Exclusion Criteria:
- Sterilized patients
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years | Effects of Lightweight Meshes in Laparoscopic Inguinal Hernia Repair on Quality of Life and Male Fertility Aspects | NCT00925067 | Entailment |
844 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Patients with either a pragmatic diagnosis of osteoarthritis of the knee, with no
other known rheumatological condition and who report the following clinical features
(based on the ACR classification for knee OA1):
- knee pain on most days of ... | Trial Evaluating Devil's Claw for the Treatment of Hip and Knee Osteoarthritis | NCT00295490 | Entailment |
4,273 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Men with azoospermia at reproductive age .
Exclusion Criteria:
- Pyospermia.
- Previous trial of cryopreservation.
- Systemic diseases.
- Cryptorchidism history.
- Smoking
Male
Subject must be at least 14 Years old.
Sub... | Oxidative Stress in Testicular Tissue Before and After Cryopreservation | NCT03621995 | Entailment |
5,168 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Ambulatory postmenopausal Korean women, ≥ 55 to ≤ 90 years of age at enrollment.
- Postmenopause is defined as no spontaneous vaginal bleeding or spotting for 12 or more
consecutive months prior to screening.
- BMD T-score </= -2.50 at the lumbar sp... | A Safety and Efficacy Study to Evaluate Romosozumab (AMG 785) in South Korean Women With Osteoporosis | NCT02791516 | Contradiction |
6,820 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients between the ages of 18 and 60 years
- American Society of Anesthesiologists (ASA) physical status I-III
- Superficial subcutaneous lipoma excision surgery (sized from 5 to 7 cm)
- Able to provide informed consent
- Consent to par... | Ultra-sounded Guided Regional Blockade for Lipoma Excision | NCT02753361 | Entailment |
1,549 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Patients presenting to the emergency outpatient unit of Geneva University Hospital
- Patients suffering from symptoms localized to the superior or inferior member, the
back, hand the chest wall.
Exclusion Criteria:
- Strictly dermatologic c... | DD Assessment With Diaana #2 | NCT03901495 | Contradiction |
5,843 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- long history of GERD symptoms
- persistent or recurrent symptoms despite optimal medical treatment
- persistent or recurrent complications of GERD
- reduced quality of life owing to increasing esophageal exposure to gastric juice
- pathol... | Laparoscopic Antireflux Surgery Versus Endoscopic Full-thickness Gastroplication for Gastroesophageal Reflux Disease (GERD) | NCT01324791 | Contradiction |
6,803 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. Hemophilia A.
2. FVIII:C <1%. 3）12 and 65 years old.
4）Has received FVIII treatment and the treatment exposure days ≥100. 5）Has bleeding
treatment records of at least 3 months before randomization. 6）FVIII inhibitor assay
results is negative. 7） Subj... | Safety, Efficacy Evaluation of Recombinant Coagulation Factor VIII Injection in Subjects With Hemophilia A. | NCT04061109 | Entailment |
1,633 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- healthy and non-smokers
Exclusion Criteria:
- unhealthy smokers
- subjects unable to understand/sign informed consent unable to understand/perform
spirometric measurements
No condition on gender to be admitted to the trial.
Accepts Healthy ... | Spirometric Predicted Values in Bolivia | NCT03660111 | Entailment |
5,204 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal women with osteoporosis, defined as low bone mineral density (BMD T-score
at the total hip or femoral neck of ≤ -2.50)
Exclusion Criteria:
- BMD T-score of ≤ -3.50 at the total hip or femoral neck
- History of hip fracture
... | Efficacy and Safety of Romosozumab Treatment in Postmenopausal Women With Osteoporosis | NCT01575834 | Entailment |
3,135 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Aged 30 years-old or over;
- Both sexes
- Affiliated to a social security scheme
Exclusion Criteria:
- severe disease compromising life expectancy at 5 years;
- Deprived of their liberty by administrative or judicial decision, or... | The Inspire Bio-resource Research Platform for Healthy Aging INSPIRE Platform | NCT04224038 | Contradiction |
693 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Hereditary haemochromatosis patients
Exclusion Criteria:
- Malignancies, severe arrhythmias, congestive heart failure and/or recent angina,
severe liver disease, epileptic seizures preceding in last 3 months before planned
treatment
No con... | Haemochromatosis:Phlebotomy Versus Erythrocytapheresis Therapy | NCT00202436 | Entailment |
2,659 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- primary inguinal hernia
- male adults
- signed informed consent
- god condition of external oblique aponeurosis (assessed during the operation)
Exclusion Criteria:
- age < 18
- recurrent hernia
- incarcera... | The Desarda and Lichtenstein Techniques in Inguinal Hernia Treatment. | NCT01237470 | Entailment |
5,520 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | PROTOCOL ENTRY CRITERIA:
--Disease Characteristics--
Diagnosis of giant cell arteritis (GCA) by at least one of the following:
- Temporal artery biopsy confirming GCA Symptoms of GCA (including new onset (within 6
months) symptoms of headaches, tenderness of the scalp or the t... | Phase II Randomized Study of Glucocorticoids With or Without Methotrexate for Treatment of Giant Cell Arteritis | NCT00004686 | Entailment |
5,870 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- • Patients (between 18 to 60 years of age) with PPI dependent GERD and pathologic
esophageal acid exposure as documented by percentage time esophageal PH less than 4 of
more than 4.2% on PH-metry during 24-hrs period while off PPI
- Patients w... | ANTI REFLUX MUCOSAL ABLATION THERAPHY (ARMA) | NCT04243668 | Contradiction |
2,183 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Age 18 years
- History of gout - crystal proven or historical as defined by ACR criteria listed above
- Serum urate level 6.8 mg/dl
Exclusion Criteria:
- Stage 4 or 5 Chronic Kidney Disease (CKD) - defined as eGFR of <30 ml/min
- ... | CSP594 Comparative Effectiveness in Gout: Allopurinol vs. Febuxostat | NCT02579096 | Contradiction |
4,069 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Key Inclusion Criteria:
Healthy Subjects:
- With habitual time in bed > 7 hours, with lights out 2200 to 2400 and lights on 0600
to 0800
- Who report typical sleep latency of </= 30 minutes
- With typical total sleep time (TST) >/= 420 minutes
Primary I... | A 2-Part Single Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of E2006 | NCT01463098 | Contradiction |
6,829 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:To be eligible for this study, patients must meet all of the following
inclusion criteria:
1. Hereditary bleeding disorder:
- Congenital hemophilia A without inhibitors with a prophylactic treatment regime
- Heterozygous carriers of hemophilia A wi... | BT200 in Hereditary Bleeding Disorders | NCT04677803 | Entailment |
498 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Women ≥18 to ≤ 40 years of age, with one or more years infertility history, desirous
of conceiving, regularly ovulating (defined as 9 or more menses per year), at
initiation of participation.
2. BMI ≥ 30 kg/m2.
3. Normal uterine cavity an... | Improving Reproductive Fitness Through Pretreatment With Lifestyle Modification in Obese Women With Unexplained Infertility | NCT02432209 | Contradiction |
2,305 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- 4 to 10 years of age
- Ambulant
- Confirmed DMD Diagnosis
- Steroid naive
- Evidence of muscle weakness by MRC score or clinical functional evaluation
- Ability to provide reproducible QMT bicep score
Exclusion Criter... | High-dose Prednisone in Duchenne Muscular Dystrophy | NCT00110669 | Entailment |
3,195 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Dry eye patients with Sjögren's syndrome finished KCT1301 study
Exclusion Criteria:
- Patients with poor adherence to medication of study drug in KCT1301 study
No condition on gender to be admitted to the trial.
Subject must be at least 20 Years old.
| An Extension Study of KCT-0809 in Dry Eye Patients With Sjögren's Syndrome | NCT02503176 | Entailment |
1,587 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
Smokers: Subjects who smoked commercial cigarettes exclusively (less than or equal to 10 mg
ISO tar yield in Germany and the UK; less than or equal to 12 mg ISO tar yield in
Switzerland) with a regular consumption of at least 1 cigarette per day over the last 12
mont... | European Exposure Study | NCT01237912 | Contradiction |
888 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Male or female patients at least 19 years of age
2. Patients diagnosed with degenerative arthritis
3. Patients with IKDC(Knee Documentation Committee subjective score) score of 60 or below
4. Patients with 100 mm VAS(Visual Analog Scale) score of 40 or ... | Efficacy and Safety Study of TissueGene-C to Degenerative Arthritis | NCT02072070 | Entailment |
3,498 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Aged 18 years or older and able to understand and sign the informed consent form.
- Patients diagnosed with hyperlipidemia and a very high risk developing
cardiovascular disease prescribed statin treatment according to clinical praxis
... | Compliance With Treatment For Patients With Hyperlipidemia | NCT00828945 | Entailment |
1,396 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- 18 years of age or older
- have diagnosed but uncontrolled hypertension
- Most recent measurement and one other measurement of the 3 most recent blood pressure
measurements in the past 2 years have a systolic pressure >140mmHg or a diastolic
... | Improving Blood Pressure in Colorado | NCT00520988 | Contradiction |
4,856 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- an endogenous hypercortisolism (group 1)
- a disease justifying the next start of glucocorticoid therapy (group 2)
- chronic adrenal insufficiency (group 3)
- subjects with either diabetes, hypertension or osteoporosis, but without
gluco... | Genomic and Metabolomic Markers Reflecting the Complications of Hypercortisolism (CUSHINGOMICS) | NCT04840693 | Entailment |
2,068 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- more than 18 years-old
- diagnosis of IPF validated in a multidisciplinary consultation meeting (RCP) according
to French recommendations
Exclusion Criteria:
- pregnant or lactating women
- exacerbation of fibrosis on inclusion
... | ThOracic Ultrasound in Idiopathic Pulmonary Fibrosis Evolution | NCT03944928 | Entailment |
5,320 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Bleeding patients.
Exclusion Criteria:
- Coagulation defects, and those on anti-platelet drugs.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
| Platelet Glycoproteins in Inherited Thrombocytopathy: Association With Aggregation Studies and Bleeding Severity | NCT03648190 | Contradiction |
3,868 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Primary knee Osteoarthritis
- Stage 2 -3 according to Kellgren - Lawrence Classification
Exclusion Criteria:
- Previous surgery in the lower extremity
- Neuromuscular disease
- Vestibular pathology
- Physiotherapy int... | Effects of Body Awareness Therapy in Knee Osteoarthritis | NCT04165187 | Entailment |
2,747 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria: inguinal hernia repair -
Exclusion Criteria: uncontrolled diabetes mellitus,
-
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years | Antibiotic Prophylaxis in Mesh Repair of Inguinal Hernias | NCT01264003 | Entailment |
3,036 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
1. Boys diagnosed with fragile X syndrome
2. Boys with intellectual disability who do not have FXS or other known genetic disorder
associated with intellectual disability
3. Age 8 to 18 years inclusive
4. Ability to travel to Stanford
... | Effects of Social Gaze Training on Brain and Behavior in Fragile X Syndrome | NCT02616796 | Entailment |
3,362 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- HV aged between 18 - 60 years
Exclusion Criteria:
- history of psychiatric disease or a positive first degree psychiatric family history
- pregnancy or lactation
- concomitant administration of any centrally activating medication (anti-depre... | Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers | NCT04355455 | Contradiction |
5,326 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- • Age ≥ 18 and < 49 years. We are including a wide range of ages because women of all
ages request TCu380A. While we recognize that some women approaching menopause (median
age = 51.4 years) may have changes in their baseline menstruation, we trust that
... | Copper IUD Treatment Observation Study | NCT02519231 | Contradiction |
670 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Male or female subjects ≥ to 18 years of age and able to give informed consent.
- Diagnosis of Iron Deficiency Anemia (IDA).
- Hemoglobin (Hgb) ≤ to 11 g/dL.
- Ferritin ≤ to 100 ng/mL or ≤ 300 when Transferrin Saturation (TSAT) was ≤ 30%.
... | Efficacy and Safety of Intravenous Ferric Carboxymaltose (FCM) in Patients With Iron Deficiency Anemia (IDA) | NCT00982007 | Contradiction |
40 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Adult male subject aged 18 to 65 years inclusive
- BMI > 30 kg/m2 and < 50 kg/m2
- Serum total testosterone concentration below the normal range
- LH levels below the upper limit of normal
- Oestradiol levels within or above the normal ra... | Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism | NCT02730169 | Contradiction |
562 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
Women must meet all the following criteria to be eligible for inclusion in the study:
1. Age 18 through 45 years (inclusive) at screening
2. Able and willing to provide written informed consent to be screened for and to take
part in the study.
3... | A Study of the Safety and Acceptability of a Placebo Vaginal Film: FAME101 | NCT03537092 | Contradiction |
3,767 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Knee pain and osteophytes on radiographs OR
- Knee pain plus patient age of 40 years or older, morning stiffness lasting 30 minutes
or less, and crepitus (cracking sound) during motion
- Experiences chronic pain for 6 months or longer
- ... | Milnacipran for Chronic Pain in Knee Osteoarthritis | NCT01510457 | Entailment |
674 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Male or female subjects > or = to 18 years of age.
- Chronically impaired renal function.
- Screening visit central laboratory hemoglobin < or = to 11.5 g/dL.
- Screening ferritin < or = to 100 ng/mL or < or = to 300 when transferrin saturation
... | Evaluation of Efficacy and Safety of Ferric Carboxymaltose (FCM) in Patients With Iron Deficiency Anemia and Impaired Renal Function | NCT00981045 | Contradiction |
6,463 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Healthy male or non-pregnant female ≥18 years-of-age with a clinical diagnosis of
moderate facial rosacea.
- Patient must have at least eight and not more than fifty inflammatory facial lesions
(i.e., papules/pustules) and ≤2 nodules on the face. F... | A Study to Evaluate the Safety and Clinical Study of Azelaic Acid Gel 15% in Patients With Moderate Facial Rosacea | NCT02120924 | Entailment |
3,617 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- All adult (18 years or older) patients presenting to the ED
- All adult (18 years or older) patients transferred from the ward to ED for upgrading
of care
Exclusion Criteria:
- All patients who died on arrival in the ED
- Patien... | Emergency Department Crowding in Relation to In-hospital Adverse Medical Events | NCT01116323 | Entailment |
6,925 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- 1. Male or female subject aged 55 to 85 y at Screening (V1). 2. Has mild to moderate
AD as defined by all of the following criteria:
1. Meets the National Institute on Aging and Alzheimer's Association (NIA-AA, 2011)
criteria of all cause ... | A Phase 3 Study of NE3107 in Alzheimer's Disease | NCT04669028 | Entailment |
985 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Being diagnosed with knee osteoarthritis
- To be in the age range of 40-70
- No lower extremity surgery in the last 6 months.
- Agree to participate in the study
Exclusion Criteria:
- Having had hip-knee replacement surgery
... | Effectiveness of Mulligan Mobilization Technique and Core Stabilization Exercise With Knee Osteoarthritis | NCT04540341 | Entailment |
4,217 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | - INCLUSION CRITERIA:
All volunteer subjects, employees and non-employees, must 18 to 40 years of age and must be
able to provide informed, written consent for participation in this study. We will not
directly advertise the study to employees to avoid the potential for coercion. Eligibility
... | Carbon Monoxide to Prevent Lung Inflammation | NCT00094406 | Contradiction |
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