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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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1,279 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Signed informed consent
- Male or female subjects ≥ 18 years of age
- ECOG PS (Eastern Cooperative Oncology Group Performance Status) of 0 or 1
- Patients with advanced malignant epithelioid mesothelioma or advanced recurrent serous
ovar... | First-in-human Study of BAY2287411 Injection, a Thorium-227 Labeled Antibody-chelator Conjugate, in Patients With Tumors Known to Express Mesothelin | NCT03507452 | Entailment |
6,210 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Medical doctor, Nurse ,Respiratory therapist or nurse assistant who work in the
emergency room, general covid ward or intensive care unit
- Age : between 18-70 years
- RT-PCR and serology tests for SARS-CoV-2 negative at baseline evaluation
... | Daily Regimen of Tenofovir/Emtricitabine as Prevention for COVID-19 in Health Care Personnel in Colombia | NCT04519125 | Contradiction |
502 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. History of 2 or more unexplained recurrent miscarriage.
2. Child bearing period (18-35 years old).
3. Non pregnant state.
4. Regular menstrual cycles for the previous three months before the study.
5. No hormonal contraception or intrauterine... | Effect of Sildenafil Citrate on Mid Luteal Phase Uterine Artery Blood Flow in Patients With Recurrent Pregnancy Loss | NCT04718233 | Contradiction |
90 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | - Healthy Men Ages 18-80
- All ethnicities eligible
- Men with indeterminate erectile dysfunction eligible with normal serum gonadotropin,
total testosterone, prolactin and TSH concentrations and documented integrity of the
neurovascular, cardiovascular, hepatorenal sy... | Steady-State Feedback Actions of Testosterone on Luteinizing Hormone Secretion in Young and Older Men | NCT00431197 | Contradiction |
6,547 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male patients less than 6 years of age with moderately severe to severe hemophilia A
(FVIII less than or equal to 2%).
- Treatment history of less than 50 exposure days to prior recombinant or plasma-derived
FVIII replacement products.
-... | Study Evaluating The Efficacy And Safety Of Xyntha In Children Less Than 6 Years Of Age | NCT00759655 | Contradiction |
1,158 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. Patients with recurrent pleural effusion of unknown origin after a first pleural tap
according to BTS guidelines.
2. Indication for thoracoscopy according to BTS guidelines.
3. Patients accept further investigation according to Danish and BTS guidelin... | Rational Approach to a Unilateral Pleural Effusion2 | NCT02834455 | Contradiction |
4,757 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Satisfy diagnostic criteria for persistent positional perceptual dizziness (PPPS) or
satisfy criteria with a duration of <3 months
- Vertigo symptom scale (VSS-SF) >12
Exclusion Criteria:
- Cognitive dysfunction that is so pronounced that i... | Internet-based Self-help Program for Vestibular Rehabilitation in Chronic Dizziness | NCT04458376 | Entailment |
5,995 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Ability to provide informed consent, preferably in writing or, failing that, orally in
front of a witness, before any study procedure is performed.
- Male and female patients aged 18 to 75 years old (inclusive).
- Patients with symptoms of functiona... | Mipolixin® Compared to Poliprotect® in Moderate Functional Dyspepsia and Heartburn. | NCT03531372 | Entailment |
4,100 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
• Adolescents (≥14 years old) and adults with a diagnosis of narcolepsy according to ICSD-3
criteria at their first ("incident") or with established diagnosis ("prevalent" subjects),
able to provide consent
Exclusion Criteria:
- inability to read, write,... | TElemedicine for NARcolepsy | NCT04316286 | Entailment |
6,456 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria for subjects:
- Aged 18 and older
- Subjects that meet one of the following criteria:
- Healthy subjects without an inflammatory facial rash or an inflammatory eye
condition
- Subjects diagnosed with ocular rosacea or cutaneo... | Lipidome and Microbiome Profile of the Eye in Rosacea | NCT03655197 | Entailment |
1,944 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Have signed the informed consent and can comply with the visit and related procedures
stipulated in the program
- Age ≥18 years old and ≤75 years old
- D2 radical resection was performed within 21-60 days before the beginning of the first
... | A Clinical Trial of Two Adjuvant Chemotherapy Regimens for Postoperative Gastric Cancer | NCT04351867 | Entailment |
4,014 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- symptomatic early knee OA
- full weight-bearing status
- have elected to receive PRP treatment
- Male veterans
- Female veterans or non-veterans
Exclusion Criteria:
- inflammatory arthritis, gout or recurrent pseudogo... | Precision Assessment of Platelet Rich Plasma for Joint Preservation | NCT03460236 | Entailment |
1,451 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- who have dysphagia symptoms and verified deglutition disorder by video fluoro
swallowing study
Exclusion Criteria:
- who reject the checkup their deglutition function by high resolution manometry
- who reject apply "Synchronized Electrical ... | Treatment of Dysphagia by Using a Synchronized Electrical Stimulation Device | NCT02718963 | Entailment |
4,293 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Healthy volunteers
Exclusion Criteria:
- Use of regular medication except the oral contraceptive pill
- Current smokers
- Significant occupation exposure to air pollution
- Intercurrent illness
No condition on gender to be admitt... | Woodsmoke Exposure and Cardiovascular Function | NCT01488500 | Entailment |
2,010 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patient consent
- Adequate tissue including adequate tumour burden
- Diagnosis of adenocarcinoma in this biopsy
Exclusion Criteria:
- No patient consent
- Inadequate tissue or block not present in archive
- No adenoca... | A Retrospective Validations Microsatellite Instability (MSI) Testing v Mismatch Repair (MMR) in Gastric Adenocarcinoma | NCT04232020 | Entailment |
4,022 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Clinical and radiological osteoarthritis of the knee and referred to physiotherapists.
2. Symptomatic daily during the last month.
3. Symptomatic for more than one year.
4. Able to walk up and down a flight of 10 stairs with or without walking aids.
... | Strongest Predictors of a Positive Outcome After Physiotherapy for Knee Osteoarthritis | NCT03113149 | Entailment |
6,344 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- 3 days or less with clinical COVID-19 symptoms (fever, cough, sour throat, headache,
body ache, anosmia, diarrhoea, vomiting).
- sign inform consent.
- >50% risk developing a severe clinical presentation of COVID-19 according to risk
ca... | Suloexide in the Treatment of Early Stages of COVID-19 | NCT04483830 | Entailment |
3,598 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
1. Menstruating females with menorrhagia or menometrorrhagia referred to hematology or
gynecology clinics at Texas Childrens Hospital. Menorrhagia is defined as regular
periods with heavy menstrual bleeding with a PBAC score greater than 100;
menomet... | Tranexamic Acid (TA) vs Combined Oral Contraceptive (COCP) Pilot Study | NCT01428713 | Contradiction |
783 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Clinical diagnosis of Osteoarthritis Disease
Exclusion Criteria:
- Others Disease orthopedics
Female
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 80 Years | Postural Analysis in Patients With Knee Osteoarthritis | NCT01031576 | Entailment |
4,371 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Being either male or female
- Being from 5 to 80 years of age
- Being considered normal weight, overweight, or obese based on specified BMI ranges
- Having a bodyweight of less than 440 pounds
- Being willing to comply with the study proc... | Tanita BIA System Validation | NCT02118675 | Entailment |
4,423 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
Invitations to participate in the study will be extended to male and female patients, 18
years and above, referred to the Orthopaedic Departments who receive a diagnosis of Lateral
Epicondyle Tendinosis (with or without degenerative changes) with symptoms present for > 3
... | Comparing Injection Treatments for Tennis Elbow | NCT03984955 | Contradiction |
1,397 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Post-menopausal females aged greater 55 years
- Prescribed alendronate 70 mg tablets for a therapeutic indication throughout the
previous 3 months and expected to continue on this treatment for the duration of the
study
- Willing to abs... | Upper GI Handling of Branded vs. Generic Alendronate | NCT00400530 | Contradiction |
4,130 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Adult male or female same or older than age of 40
- Severity of acute exacerbation of Chronic obstructive pulmonary disease(COPD) must
suit oral administration treatment
- Diagnosed as COPD before receiving written informed consent and outcome measu... | A Study to Evaluate Efficacy and Safety Profile of Zabofloxacin Tablet 400mg and Moxifloxacin Tablet 400mg | NCT01658020 | Contradiction |
5,434 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Males and females 18 years of age or older
- Confirmed VWD by 2 of 4 VWD coagulation tests abnormal
- A past bleeding history
- No hormone, oral contraceptive, estrogen use in past 8 weeks
- Willingness to have blood drawn
- W... | Phase II Study of IL-11 (Neumega) in Von Willebrand Disease | NCT00151125 | Entailment |
3,677 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- Patients with suspected CES
- Minimum age 18 years.
- Both sexes
- Able to provide informed consent for their data to be included in the study
Exclusion Criteria:
- Patients with pre-existing urinary tract pathologies (neuropathi... | Post-void Bladder Scanning in Acute Cauda Equina Syndrome | NCT02806167 | Entailment |
4,735 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Must be female
- Aged 18 to 50 years, with regular menstrual cycles.
- Healthy volunteers and women with von Willebrand's disorder are both being recruited.
Exclusion Criteria:
- Pregnancy
- Use of hormonal therapy including birt... | Changes in Bleeding and Clotting During the Menstrual Cycle | NCT00480545 | Entailment |
4,902 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Participant has been implanted with the DBS for ET
- Participant has significant voice tremor as determined by our
laryngology/speech-language pathology team
Exclusion Criteria:
- Participant does not have history of aphasia or other speech... | Deep Brain Stimulation for Voice Tremor: Left, Right, or Both Hemispheres? | NCT02960243 | Contradiction |
6,666 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
Part A (PTPs):
- Chinese participants with severe hemophilia A (defined as Factor VIII (FVIII): C < 1%
with one- stage clotting assay documented at the time of screening)
- Currently receiving on-demand or any type of prophylaxis treatment regimen with a... | A Post Approval Commitment Study to Gain More Information on How Safe and Effective KOVALTRY is in Chinese Children, Adolescents /Adults With Severe Hemophilia A | NCT04565236 | Contradiction |
5,122 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- aged ≥ 65
- Functional Ambulation Category (FAC) score ≥ 3
- able to walk for ≥ 10 meters
- living in the community
- Montreal Cognitive Assessment-5-minute protocol score ≥ the 16th percentile of the age
and education adjust... | Effects of FRAX+SARC-F Pre-screening on Preventing Fragility Fracture and Fall in Community-dwelling Older Adults | NCT04709393 | Contradiction |
4,731 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Key Inclusion Criteria:
- Healthy male and female subjects between 18 to 65 years of age.
- Subjects' weight ≥ 50 kg and BMI within the range of 19 - 29 kg/m2.
- Physical examination and vital signs are within normal range or slightly abnormal.
Key Exclusion Criteria:
... | Study to Evaluate Safety, Tolerability and Pharmacokinetics and Pharmacodynamics of ASC42 in Healthy Subjects | NCT04679129 | Entailment |
6,941 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion criteria
- Subjects aged 60 or over
- Subjects with Alzheimer's disease, according to the NINCDS/ADRDA diagnostic criteria
71
- MMSE > 18
- Subjects with at least one VRF (whether treated or not): arterial hypertension
(defined as SBP/D... | Impact of Controlling Vascular Risk Factors on the Progression of Alzheimer's Disease | NCT01423396 | Entailment |
5,770 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- 1. Male or female patients aged ≥18 years old with severe primary RAS resistant to
colchicine prescribed at a dose of 1mg/day or more for at least 3 months, or
intolerant to colchicine
Severity of primary oral aphtous ulcer is defined by the presence ... | Randomized Double Blind Controlled Trial Comparing the Safety and Efficacy of Apremilast Versus Placebo in Severe Forms of Recurrent Aphthous Stomatitis | NCT04227314 | Contradiction |
1,007 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Able and willing to give informed consent and to comply with the study protocol and
follow-up instructions.
- Symptomatic OA of the knee, as defined by the American College of Rheumatology's
Clinical Criteria for Classification and Reporting of OA ... | The Effects of Specialized Footwear in Osteoarthritis | NCT01597830 | Entailment |
4,558 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Willing to provide informed consent
- Willing to take COCs and follow all study requirements
- Has regular menstrual cycles every 21-35 days (when not taking hormonal contraception)
- Last menstrual period (LMP) <35 days before study entry
... | Interactions Between Antiretrovirals (ARVs) and Combined Oral Contraceptives (COCs) | NCT00829114 | Contradiction |
5,600 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Adolescents between 13 and 19 years old.
- Obese or overweight according to the IOTF.
- No physical or medical impediment for performing physical activity.
- No risk for eating disorders (SCOFF questionnaire).
- Report less than 20 minute... | Use of Facebook as a Motivating Factor in a Weight-reduction Program for Obese and Overweight Adolescents | NCT01819376 | Contradiction |
3,931 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Individuals diagnosed with knee osteoarthritis II-III level according to the results
of radiological evaluation by Kellgren and Lawrence
- Individuals aged between 40 and 65 years
- Individuals who have pain in his/her either of the knees in 3 month... | The Validity, Reliability and Responsiveness of the Fullerton Advanced Balance Scale in Osteoarthritis | NCT03728387 | Entailment |
4,087 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
1. Patients diagnosed with narcolepsy type 1 or type 2 based on the International
Classification of Sleep Disorders, third edition (ICSD-3) criteria for at least 6
months - diagnosis for at least 6 months will ensure that initial fluctuations due to
... | 'A Profile of Physical Performance Variables in an Out-patient Adult Population With Narcolepsy' | NCT04419792 | Entailment |
6,189 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients who are admitted to Hospital Centers with a positive RT-qPCR SARS-CoV-2 test
or a CT scan compatible with a diagnosis of COVID-19 pneumonia, in addition to one of
the following two criteria:
1. Severe respiratory failure [respiratory r... | Convalescent Plasma vs Human Immunoglobulin to Treat COVID-19 Pneumonia | NCT04381858 | Contradiction |
3,280 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- aged of 18 years or more
- Primary Sjögren's Syndrome Patients who have already participated to the study ASSESS
Exclusion Criteria:
- secondary Sjögren's Syndrome (SJ) associated with other autoimmune diseases
No condition on gender to be admitted to t... | The ASSESS National Multi-center Prospective Cohort | NCT03040583 | Entailment |
1,315 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | - ELIGIBILITY CRITERIA FOR ALL PARTICIPANTS:
All study participants must be of self-described African or African American ancestry. They
will be at least 18 years old and must be able to provide informed, written consent for
participation.
INCLUSION CRITERIA:
Inclusion Criter... | Genetics and Pain Severity in Sickle Cell Disease | NCT01441141 | Contradiction |
3,445 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Adult male and female in-patients with vital signs considered 'stable' by clinical
caregivers.
Exclusion Criteria:
- Pediatric patients
- Female patients who are pregnant
- Patients with internal or external defibrillators
... | Vital Signs Patch Early Feasibility and Usability Study | NCT02521922 | Entailment |
4,938 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | INCLUSION CRITERIA:
- Patients with alcohol-responsive Essential Tremor
- Limb involvement should be a prominent feature of the Essential tremor
- Patients must be willing and able to safely stop and remain off any medications used
to treat essential tremor for at least ... | Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor | NCT00102596 | Entailment |
4,213 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Age between 18-45 years old;
- Male body weight not less than 50kg; Female body weight not less than 45kg; BMI in the
range of 19~28kg/m2
- Healthy men or women based on history, physical examination, laboratory examination
and ECG.
... | Pharmacokinetics and Safety of ASC16 Tablets in Healthy Volunteers in China | NCT03288636 | Contradiction |
6,116 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Age at least 18 years
2. Ability and willingness of participant or Legally Authorized Representative (LAR) to
give written informed consent.
3. Laboratory confirmed diagnosis of infection with SARS-CoV-2 by PCR
4. Hospitalized for COVID-19 ... | COVID-19 Antibody Plasma Research Study in Hospitalized Patients | NCT04524507 | Contradiction |
5,493 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Patients suspected of temporal arteritis and referred by their physicians to biopsy of
a temporal artery.
Exclusion Criteria:
- Pregnancy; age > 80 or < 18; unable to answer study questions
No condition on gender to be admitted to the trial.
No healthy... | Diagnostic Study of Temporal Arteritis | NCT01130857 | Contradiction |
6,406 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. - Probable COVID-19 based on presence of at least 5 of the following symptoms of acute
onset within the prior 4 days: fever, cough, sore throat, fatigue, episodic chest pain
or shortness of breath with exercise, muscle or body aches, headache, loss of smell or... | Remotely-conducted Trial of Famotidine vs Placebo for Patients at Home With Coronavirus (COVID) of 2019 (COVID-19) | NCT04565392 | Entailment |
3,890 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Is male or female ≥ 40 years of age
- If a participant in the previous MEL3-12-02 study, completed the study and did not
discontinue for lack of efficacy or safety
- Has a diagnosis of OA of the hip or knee with ongoing knee and/or articular hip pai... | Study of Meloxicam Capsules in Subjects With Osteoarthritis of the Knee or Hip | NCT01801735 | Entailment |
4,789 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Subject has subjective unilateral tinnitus and is consistently aware of their tinnitus
throughout much of the waking day.
- Subject is able to use the electronic diary to complete their daily tinnitus ratings
- Subject's tinnitus is likely of cochle... | OTO-313 in Subjects With Subjective Tinnitus | NCT03918109 | Entailment |
5,388 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Employee or dependent of an intervention or control employer
Exclusion criteria:
- Not continuously enrolled in health plan and therefore some claims may be missing
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subjec... | The Effect of Financial Incentives on Utilization of Low-cost Providers | NCT02249156 | Entailment |
4,527 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Body Mass Index between 20-30 Kg/m2
- regular menstrual cycles
- sedentary lifestyle (physical activity not more than 30 minutes per day three times a
week)
Exclusion Criteria:
- Fasting blood sugar greater than 110 mg/dL
... | Menstrual Cycle Hormones and Eating Behavior | NCT01407692 | Contradiction |
1,791 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion criteria:
- Apparently healthy; no medical conditions that might affect the study measurements (as
determined by the study physician)
- No use of medication that would interfere with the study measurements (as determined
by the study physician)
- N... | MRI Study of Stomach Volumes and Satiety | NCT01690182 | Contradiction |
4,120 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- All Non obstructive Azoospermic Patients.
- Azoospermic Patients due to Administration of Chemo/Radiotherapy.
Exclusion Criteria:
- Patients with Testicular Cancer.
- Patients with Complete Deletion of Chromosome Y AZF (a,b,c) Regions.
Male
... | MSCs For Treatment of Azoospermic Patients | NCT02025270 | Contradiction |
230 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- 1-Aged 20-35 yr, male factor, 2-Tubal or unexplained infertility, 3-regular
menstruation cycle between 21 and 35 days, 4-Normal function of uterus according to
hysterosalpingography, hysteroscopy or transvaginal ultrasonography, 5-Normal ovaries
a... | Controlled Ovarian Hyperstimulation (COH) With Sequential HPFSH & HMG Versus Rec-F.S.H Alone in ICSI Cycle | NCT04539613 | Contradiction |
4,656 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
Premenopausal women aged 30 - 50 years old scheduled for vaginal, abdominal or laparoscopic
total hysterectomy one or more of the following clinical symptoms:
- bleeding disorders (menorrhagia, irregular bleeding, hypermenorrhoea),
- chronic pelvic pain,
... | Norwegian Adenomyosis Study II: Gene Expression Profiling of Adenomyosis | NCT02197923 | Entailment |
6,965 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria for Alzheimer patient group:
- Signed Informed Consent.
- Male or female subject, between 55 and 85 years inclusive.
- Specific clinical phenotype of AD: Presence of an early and significant episodic
memory impairment (isolated or associated with other... | ADDIA Chronobiological Study | NCT02973971 | Entailment |
1,696 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Adults over 18, capable of informed consent
Exclusion Criteria:
- History of arrhythmia. Has implanted pacemaker or defibrillator, right
wrist-to-sternum distance of less than 60 centimeters, visible tattoos of the right
hand or wrist, or ... | Sensory Effects of Rapidly-Changing Magnetic Fields | NCT01632800 | Entailment |
1,637 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- be an amateur practitioner of the Crossfit modality with at least 6 months of regular
sports practice (at least 4 times a week)
- between 18-40 years old
- agree to participate in the study and sign the informed consent form (ICF).
Exclusio... | Influence of Wrist Taping on Handgrip Strength in Crossfit Athletes | NCT04780906 | Entailment |
845 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Hand OA
- Age over 40
- Visual analogic scale (VAS) for pain at rest between 3-8cm
- Signed informed consent term
Exclusion Criteria:
- Change in the use of oral corticosteroid or nonsteroidal antiinflammatory (NSAID) in
... | Corticosteroid Intra-articular Injection in Hands Osteoarthritis | NCT02102620 | Entailment |
475 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age 18-50 years, inclusive
- General good health (by volunteer history and investigator judgment)
- Currently having regular menstrual cycles of 21 - 35 days by volunteer report
- Protected from pregnancy, meaning one of the following: Sexually absti... | Assessing the Disintegration, Safety, and Acceptability of Placebo Vaginal Inserts for the Delivery of Vaginal Products | NCT02534779 | Contradiction |
6,419 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Subjects must have a Fitzpatrick skin type of I-IV and have Rosacea as evaluated by
the treating physician.
- Subjects must have visible telangiectasia on the side of the face.
- Subjects must be willing and able to comply with all follow-up require... | EVALUATION OF THE EFFECT OF THE PERFECTA V-BEAM LASER ON ROSACEA | NCT03211585 | Entailment |
6,787 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male subjects 18 to <65 years old with severe hemophilia A or B with or without
inhibitors to FVIII or FIX.
- Subjects is willing and able to comply with the mandatory washout periods prior to
screening and prior to dosing and through 48 hours post... | Phase 1 Safety, Pharmacokinetics And Pharmacodynamics Study Of Recombinant Factor VIIa Variant (813d) In Adult Subjects With Hemophilia | NCT01439971 | Entailment |
176 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
Low testosterone
Exclusion Criteria:
- Normal testosterone levels
- Elevated Prostatic Specific Antigen (PSA)
- History of breast or prostate cancer
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subje... | An Efficacy and Safety Study of ABT-SLV176 for the Treatment of Hypogonadal Men | NCT02082197 | Entailment |
3,788 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
Patient must be willing and able to give informed consent for participation in the study
- Age 18-80 years
- Knee Pain
- WOMAC Pain Subscale ≥ 5 during screening
- Mean Visual Analogue Scale (VAS) ≥ 5 during 1 week of screening.
- ... | Efficacy of Cannabidiol in Knee Osteoarthritis | NCT04607603 | Entailment |
3,586 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Healthy male or female subjects between the ages of 18 and 55 years
- Negative urine pregnancy test on Day1 for females of childbearing potential
- Weight within +/- 20 percent of ideal weight according to the Metropolitan Life Height
and Weight cha... | Effect of Meloxicam Tablets on Bleeding Time in Healthy Subjects | NCT02183155 | Contradiction |
4,333 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- HV aged between 18 - 60 years
Exclusion Criteria:
- history of psychiatric disease or a positive first degree psychiatric family history
- pregnancy or lactation
- concomitant administration of any centrally activating medication (anti-depre... | Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers | NCT04355455 | Contradiction |
1,474 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
1. Male and female patients between 20 to 80 years old
2. Patients with at least one condition below
- Systolic blood pressure is 140mmHg or higher, or diastolic pressure is 90mmHg or
higher, and 2 or more cardiovascular risk factor, and low-d... | Clinical Study to Evaluate Adherence Improvement Fixed-dose Combination of Olostar Tab. in Patients With Hypertension and Dyslipidemia | NCT04061824 | Entailment |
5,331 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Healthy female nonsmoking subjects, ages 18 to 40 years, inclusive with a body mass
index of 18.0 kg/m2 to 32.0 kg/m2, inclusive
- Women of child bearing potential with intact ovarian function by medical history and
history of regular menstrual cyc... | A Drug-drug Interaction Study Between BMS-663068 and Oral Contraceptives in Healthy Female Volunteers (DDI) | NCT02480881 | Contradiction |
2,872 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- ALS diagnosed as possible, laboratory-supported probable, probable, or definite as
defined by revised El Escorial criteria
- Age 18 years or older
- Exhibits bulbar dysfunction manifested by dysarthria and/or dysphagia, according to PI
... | Clinical Trial Nuedexta in Subjects With ALS | NCT01806857 | Entailment |
1,207 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. > 18 years of age
2. Recurrent pleural effusion due malignancy Malignant pleural effusions are defined as
either Fluid in the context of histocytologically confirmed pleural malignancy, or
pleural fluid in the context of histocytologically confirmed... | Investigation Into the Automated Drainage of Recurrent Effusions From the Pleural Space in Thoracic Malignancy. | NCT01952327 | Entailment |
5,619 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Adult height prediction below -2.5 SD : 151 cm for girls and 164 cm for boys based on
the vlaamse groeicurve 2004 (vub.ac.be/groeicurven)
- Pubertal: breast development at least M2 for girls and at least 4 ml of testicular
volume for boys
... | A 4 Year Combination Therapy of Growth Hormone and (GnRH) Agonist in Children With a Short Predicted Height | NCT00840944 | Contradiction |
1,979 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Biopsy proven adenocarcinoma of the stomach
- Treated with palliative intent
- At least one index symptom such as bleeding, obstruction or pain
- No prior abdominal radiotherapy
- Not on chemotherapy
Exclusion Criteria:
... | Palliative Radiotherapy for Symptomatic Locally Advanced Gastric Cancer: A Phase II Trial | NCT01341756 | Entailment |
3,585 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Bleeding patients.
Exclusion Criteria:
- Coagulation defects, and those on anti-platelet drugs.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
| Platelet Glycoproteins in Inherited Thrombocytopathy: Association With Aggregation Studies and Bleeding Severity | NCT03648190 | Contradiction |
1,954 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Age≥18 years;
2. Pathologically diagnosed with advanced gastric adenocarcinoma (including
gastroesophageal junction) with measurable metastases outside the stomach (≥10mm on
spiral CT scan, and meet the criteria of Response Evaluation Criteria in So... | Apatinib as Maintenance Therapy After First Line Treatment in Locally Advanced or Metastatic Gastric Cancer | NCT02537171 | Entailment |
332 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- 3- On antagonist protocol 4- Poor responder according to ESHRE consensus; in which at
least 2 of the following should be present:
- Advanced maternal age (≥ 40 years old) or any other risk factor
- A previous poor ovarian response (cycles cancelled ... | Prediction of Metaphase II Oocytes According to Different Levels of Serum AMH in Poor Responders Using the Antagonist Protocol | NCT03484611 | Contradiction |
4,724 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Signed informed consent before any trial related activities
- Female of 18 - 50 years of age
- Subjects suspected with cystic endometriosis or adenomyosis confirmed by transvaginal
ultrasonography (or transrectal ultrasonography for unmarried subjec... | DLBS1442 for The Treatment of Pain in Patients Suspected Endometriosis | NCT01942122 | Entailment |
75 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Male
- In good health
- Aged 18-35
Exclusion Criteria:
- Female
- Known carcinoma of the breast or prostate
- Known sensitivity to alcohol or soy products
- Preexisting cardiac, renal, or hepatic diseases
... | Study on the Effects of Exogenous Testosterone on Threat Perception and Behavioral Avoidance | NCT01408498 | Contradiction |
4,648 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Patient who undergo laparoscopic assisted vaginal hysterectomy due to following
gynecologic disease
1. uterine leiomyoma
2. uterine adenomyosis
3. Endometrial hyperplasia
4. cervical intraepithelial neoplasia ... | Study of Laparoendoscopic Single Site Hysterectomy in Benign and Preinvasive Uterine Disease | NCT01679548 | Entailment |
3,846 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Men and women diagnosed with primary or secondary osteoarthritis of the
knees,classified as grades I to IV Kelgreen and Lawrence (KL), ie, any degree of knee
osteoarthritis
Exclusion Criteria:
- Patients who have psychiatric or neurologica... | Project Osteoarthritis: Recovering Quality of Life Through Education | NCT01572051 | Entailment |
4,736 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women with benign conditions such as uterine fibroids, menorrhagia, adenomyosis,
pelvic pain, abnormal uterine bleeding
Exclusion Criteria:
- None
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years | Does 3D Laparoscopy Improve Vaginal Cuff Suture Time? | NCT02192606 | Entailment |
14 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Men age 18 through 69 years old
- Men who are distressed by their low libido as defined by SDI-2, and SCI-M
questionnaires. (Appendices A,C)
- Men who are not depressed as defined by PHQ-9 (Patient Health Questionnaire) score of
9 or le... | Hypoactive Sexual Desire Disorder in Males (10-18-40-13) | NCT04002661 | Contradiction |
2,469 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- Main diagnosis: previously diagnosed sarcoidosis according to the latest ATS/ERS/WASOG
statement on sarcoidosis (AJRCCM 1999)
Exclusion Criteria:
- A history of neurosarcoidosis
- Undergoing structured exercise training at the time of enrol... | Exercise Training in Sarcoidosis (EXTRAS Study) | NCT00099424 | Entailment |
4,112 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Adult subjects with COPD, 40 - 75 years of age
- All subjects must have a diagnosis of COPD and must have airway obstruction with a
post-bronchodilator Forced Expiratory Volume in 1 sec (FEV1) of >/= 30% and <= 80% of
predicted and a post-bronchodi... | Study in COPD (Chronic Obstructive Pulmonary Disease) Subjects to Investigate Safety, Tolerability, and Pharmacokinetics of Ciprofloxacin After Single Dose Inhalations of 50 mg and 75 mg Ciprofloxacin Inhalation Powder | NCT01168895 | Contradiction |
4,547 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Normal menstrual cycles of 25-35 days in length for at least previous 3 cycles
- 21-40 years of age
- BMI > 18, < 30
- Serum P4 > 9 ng/ml on single sample collected between days 18-25 of self-reported
menstrual cycle
- Flexib... | Relationship Between the Menstrual Cycle and Heart Disease in Women | NCT01546454 | Contradiction |
307 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age >/= 18 years
- Female gender
- >/= Stage II pelvic organ prolapse
- Clinical diagnosis of pelvic organ prolapse and desiring non-surgical management with
pessary
- Ability to provide informed consent and complete all stud... | Vaginal Creams to Reduce Vaginal Erosion in Pessary Users | NCT02316249 | Contradiction |
2,335 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
For non-ambulant patients:
1. Children and teenagers aged between 5 and 18 years with DMD, who have lost the ability
to walk 10 meters with no support
2. The diagnosis of DMD must be documented by genetic testing. If a muscle biopsy is
availab... | Outcome Measures in Duchenne Muscular Dystrophy: A Natural History Study | NCT02780492 | Entailment |
5,123 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Females
- Postmenopausal women
- Outpatients screened for osteoporosis
- Women > 45 years
- Women < 45 years under menopause
- Women obtained their consent to be measured
Exclusion Criteria:
- Premenopausa... | Osteoporosis Screening Trial | NCT01677637 | Contradiction |
2,549 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Diagnosis of AD by physician at birth-15 years old
- Diagnosed by physician by Hanifin and Rajka criteria: itching, dry skin, chronic
dermatitis : at face, extensor area (infant), flexor area (children and adult), with
or with out history of atopy ... | The Natural History of Atopic Disease in Thai Children and Association With Atopic March | NCT02532920 | Entailment |
5,488 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Decreased visual acuity (BVA) <5 days, regardless of degree of severity, abrupt onset
in the context of newly diagnosed or suspected Horton's disease at this loss of visual
acuity
- Able to sign the consent
- Affiliated to the social se... | Study of the Benefit of Early Treatment With an Endothelin Inhibitor (Bosentan) in Patients With Sudden Blindness Due to Giant Cell Arteritis: CECIBO | NCT03841734 | Contradiction |
5,336 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
1. Voluntarily signed the informed consent as applicable to participate in the study, age
18-55, inclusive, male: female=1:1;
2. Body mass index between 18.5-26 kg/m², inclusive, with a body weight ≥50 kg (male),
≥45 kg (female);
3. Consider... | A Phase I Study of TACI-antibody Fusion Protein Injection (RC18) in Healthy Adult Chinese Subjects | NCT04235933 | Contradiction |
4,463 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- age 18 to 65 years
- confirmed lateral epicondylitis
- had not received any treatment prior to enrolment
Exclusion Criteria:
- symptoms lasting less than 6 weeks
- history of acute trauma, fracture, and/or surgery within 12 month... | Effectiveness of Steroid Injection in Treating Patients With Lateral Epicondylitis | NCT01986465 | Contradiction |
224 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Adult men ≥18 and ≤75 years of age with a documented history of hypogonadism
- Total testosterone levels < 300 ng/dL at two qualification visits
- Patients in good general health
Exclusion Criteria:
- Allergy to sesame or testosterone produc... | Subcutaneous Testosterone Enanthate Safety in Adult Men Diagnosed With Hypogonadism | NCT02504541 | Entailment |
914 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Ages 45 and older
Joint pain inclusion will be considered with a mild [Mild pain (0-44)] to moderate pain
level [Moderate pain (45-74 mm)] (Hawker, Mian, Kendzerska, & French, 2011) not completely
relieved by medications.
Measured decreased range of motio... | Horses and Education as Arthritis Therapy | NCT03141853 | Entailment |
6,153 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
-Healthy healthcare workers
Exclusion Criteria:
- Healthy healthcare workers' refusal.
- Pregnancy and lactation.
- Confirmed acute cases of SARS-CoV-2 Infection
- Having a history of SARS-CoV-2 infection in the past 3 months.
... | Safety and Immunogenicity of Inactivated Vaccine Against COVID-19 Infection | NCT04756271 | Contradiction |
4,529 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Informed consent: signed written informed consent before inclusion in the study;
2. Sex and Age: healthy pre-menopausal women, 20-45 years old inclusive;
3. Body Mass Index: 18.5-30 kg/m2 inclusive;
4. Vital signs: systolic blood pressure 100-139 mmHg, ... | Comparative Bioavailability Study of Human Chorionic Gonadotropin (hCG)-IBSA Versus a Marketed hCG Formulation | NCT03735030 | Contradiction |
2,697 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- healthy males, who are not taking Tamsulosin regularly who are undergoing elective
inguinal hernia repair (laparoscopic, open, and robotic assisted)
Exclusion Criteria:
- Patients who are already taking tamsulosin, terazosin (alpha blocker treatement f... | Preoperative Administration of Tamsulosin for Prevention of Post Operative Urinary Retention in Males Undergoing Elective Inguinal Hernia Repair | NCT02958878 | Entailment |
3,705 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Age 50-85
- Diagnosed with Knee Osteoarthritis by a physician or by ACR clinical criteria
Exclusion Criteria:
- sensory dysfunction due to injury (i.e. known nerve damage)
- neurological diagnosis affecting sensory or motor function (e.g. st... | Pain Phenotypes in Knee Osteoarthritis | NCT02664896 | Contradiction |
2,349 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
1. Boys aged between 5 and 16 years inclusive.
2. Duchenne muscular dystrophy resulting from a mutation correctable by treatment with
PRO044.
3. Life expectancy of at least 6 months.
4. No previous treatment with investigational medicinal trea... | Phase I/II Study of PRO044 in Duchenne Muscular Dystrophy (DMD) | NCT01037309 | Entailment |
6,564 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients with hemophilia A who have been treated with factor VIII on demand or on
prophylaxis and who have developed inhibitors to factor VIII
- ≤ 2 years from the time of first inhibitor detection.
- High-responding inhibitors (historical peak > 5 ... | rFVIIa Prophylaxis in Children With Hemophilia A and Inhibitors | NCT01105546 | Contradiction |
6,215 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Symptomatic with COVID illness (either RT-PCR test confirmed or highly suspect
clinical symptoms)
- Call into office within the first 7 days of illness
- Have any of the following high risk conditions:
- Age >60
- H... | Hydroxychloroquine Treatment of Healthcare Workers With COVID19 Illness at Montefiore | NCT04350450 | Contradiction |
4,841 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Aged 18 years old or over
- Patient with a diagnosed Cushing's disease according to the French "protocole national
de diagnostic et de soins (PNDS)"
- Patient who underwent a MRI pituitary for diagnostic purposes
- Patient who have under... | Impact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's Disease | NCT03346954 | Contradiction |
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