id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
values | statement_pol stringclasses 50
values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
values |
|---|---|---|---|---|---|---|---|
2,080 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Individuals over the age of 18 with a diagnosis of definite or probable IPF or
definite or probable fibrotic NSIP as defined by the ATS/ERS consensus classification
Exclusion Criteria:
- Patients with co-existent conditions known to be associated with ... | Prospective Observation of Fibrosis in the Lung Clinical Endpoints Study | NCT01110694 | Entailment |
6,795 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Severe hemophilia A
- Previously treated patients with at least 150 exposure days to any Factor VIII product
Exclusion Criteria:
- Hypersensitivity to any recombinant Factor VIII product
- History of or current Factor VIII inhibitor
... | Study Comparing Blood Levels of ReFacto and Advante in Hemophilia A | NCT00168051 | Entailment |
5,221 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion criteria：
- Age>=50
- New hip fracture from orthopedic ward
- Newly identified vertebral fracture (either morphological or clinical)/ old hip
fracture without osteoporosis treatment referred by team physicians either inpatients
or outpatients
... | Randomized Fracture Liaison Services | NCT03178799 | Entailment |
6,735 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Study population will include: adult males ≥18 years of age with a diagnosis of severe
hemophilia A and currently active high titer FVIII inhibitors (>5 BU). Females will be
excluded because hemophilia A is an X-linked disorder that is extremely rare in
... | Gene Therapy Trial for Platelet Derived Factor VIII Production in Hemophilia A | NCT03818763 | Contradiction |
1,227 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. Patients undergoing investigation or treatment for thoracic cancers with
oncogene-targeted therapies
2. Aged 18 years or older
3. Either a) have suspected tumor progression or other condition that dictates a
standard-of-care palliative, t... | Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung Cancer | NCT01580982 | Entailment |
2,190 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- The participant, or the participant's legally acceptable representative, signs a
written informed consent form/Health Insurance Portability & Accountability Act
(HIPAA) Authorization prior to the initiation of any study procedures.
- Must have a hi... | Effect of Febuxostat on Joint Damage in Hyperuricemic Subjects With Early Gout | NCT01078389 | Contradiction |
2,913 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Male or female between the ages of 18 and 85 with clinical diagnosis of ALS
- Forced Vital Capacity (FVC) > 60% of predicted
- Less than 3 years of ALS since the onset of the first symptom with clinical evidence
of limb muscle atrophy and weakness.
... | Clinical Trial of SB-509 in Subjects With Amyotrophic Lateral Sclerosis (ALS) | NCT00748501 | Entailment |
2,736 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Primary unilateral groin hernia in adult
Exclusion Criteria:
- recurrence warfarin treatment bilateral groin hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject mu... | A Multi-site Trial Comparing Lichtensteins Operation and Prolene Hernia System in Inguinal HErnia Repair | NCT00184483 | Entailment |
6,884 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Intact activities of daily living
- Fluent in German
- Normal/corrected-to-normal vision
- Written informed consent
Exclusion Criteria:
- Dementia
- Current/lifetime severe psychiatric or neurological disorder
... | Real-time fMRI Neurofeedback in Patients With MCI | NCT04020744 | Contradiction |
5,800 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Individuals with dermatological condition (including conditions that affect the skin,
hair and/or nails). This includes, but is not limited to, acne, eczema, alopecia,
psoriasis, vitiligo, rosacea, dermatitis, hyperpigmentation, hidradenitis suppurativa
... | Testing a Body-functionality Intervention for Body Image in Individuals With Skin Conditions | NCT04445974 | Entailment |
1,448 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Females of childbearing potential who are sexually active must agree to use adequate
contraception from screening throughout the duration of the study and for 30 days
following the last dose.
- Has a documented history of dyslipidemia with or witho... | Efficacy of Lapaquistat Acetate Alone and With Ezetimibe in Subjects With Primary Dyslipidemia. | NCT00268697 | Entailment |
4,915 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
1. You provide informed consent.
2. You are over 21 years of age.
3. You are diagnosed with a postural-intention (essential) tremor for at least 3 years
and meet strict diagnostic criteria and have been seen and examined by a movement
disord... | Responsive Deep Brain Stimulator for Essential Tremor | NCT02649166 | Entailment |
2,526 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Diagnosis of moderate or severe atopic dermatitis based on Eczema Area and Severity
Index (EASI) score (moderate=6-22.9; severe=23-72)
- At least one active patch of atopic dermatitis at time of study
- Parent/guardian able to give informed consent
... | Tencel vs. Standard Cotton Therapeutic Garments as an Adjunct Treatment for Moderate to Severe Atopic Dermatitis in Children | NCT03843437 | Entailment |
701 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- 18 years old and over
- Written consent.
- For DIOS Group : at least one criteria of the metabolic syndrome as defined by the
International Diabetes Federation, associated with hepatic iron overload measured by
MRI (at least 50 µmol/g) ... | Effects of Polyphenols on Iron Absorption in Iron Overload Disorders. | NCT03453918 | Entailment |
4,193 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
non-smoker
- no history of pulmonary disease
- absence of dyspnoea, cough, thoracic pain
- no self-reported smoking history
- normal lung function testing
- normal shape of flow-volume curve
- normal shape of ... | Multiple Breath Washout (MBW) Using Sulfur Hexafluoride Reference Values and Influence of Anthropometric Parameters | NCT04099225 | Contradiction |
5,069 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- All the patients received vertebroplasty treatment between 2005.01-2011.12 with 2nd
fracture in the vertebral column.
Exclusion Criteria:
- No image available
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the ... | Imaging Parameters to Predict Future Vertebral Fracture in Osteoporosis | NCT01653873 | Contradiction |
5,196 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Be sedentary (less than 2 hours physical activity of low intensity per week)
- Fracture risk Densitometry Risk factors (FRAX) index between 3 and 10%
- Consent form signed
Exclusion Criteria:
- Bone concomitant disease (such as Paget's disea... | Effects of Whole Body Vibration (WBV) on Musculoskeletal System of Aged Women | NCT01982214 | Entailment |
5,349 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Subject is at least 18 years of age but no more than 75 years of age.
- Subject has a posterior (molar or premolar) socket created by atraumatic extraction
with a post extraction socket of a minimum of 5 mm in both the mesial-distal (M-D) and
bucca... | Safety Study of Gintuit™ in Subjects Requiring Socket Grafting | NCT01929954 | Contradiction |
183 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Ages 18-65
- History of hypogonadism
- In good health based on medical history, physical examination and clinical laboratory
tests
- Screening morning serum testosterone ≤ 297 ng/dL
- One or more symptoms of testosterone defi... | Efficacy, Pharmacokinetics and Safety of Testosterone | NCT01370369 | Entailment |
4,132 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Candidate patients will have evidence of an acute lower respiratory tract infection
(pneumonia or acute exacerbation of chronic bronchitis) as defined as follows:
o NEW onset within past 28 days
- At least one respiratory symptom: cough, sputum pr... | Procalcitonin for Stewardship in Respiratory Infections A Stewardship Project | NCT03109106 | Contradiction |
1,372 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
Patients with large rotator cuff tears (Type 1B or Type 2) determined by clinical
examination and diagnostic imaging. Criteria described by Harryman et al (1991) will guide
the classification of rotator cuff tears defined and reassessed at the time of surgery
(Type 0... | An RCT to Compare the Outcomes of Patients With Large Rotator Cuff Repair That Undergo Repair With or Without SIS | NCT00182299 | Contradiction |
3,551 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- chronic primary or secondary adrenal insufficiency requiring glucocorticoid
substitution therapy
Exclusion Criteria:
- adrenocortical carcinoma
- long term glucocorticoid treatment above 7.5 mg prednisone equivalent dose for other
... | Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency | NCT01184209 | Entailment |
1,955 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- All out-patients > 19 years old presenting for capsule endoscopy
Exclusion Criteria:
- Patients on narcotics
- Patients on motility enhancing and/or slowing drugs should stop these at least 5 days
prior to the procedure or be excluded from ... | The Effect of Chewing Gum on Small Bowel Transit Time | NCT01241825 | Entailment |
4,864 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Age over 18 years
- Under investigation for hypercortisolism
- Able and willing to make informed consent
Exclusion Criteria:
- Use of systemic or local glucocorticoids
No condition on gender to be admitted to the trial.
No healthy subjects a... | Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome? | NCT01504555 | Entailment |
2,561 | 19 | A 7-year-old girl is brought to the emergency department by her parents for generalized rash. The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll. Her mother suspects that something had stung her. The patient's blood pressure ... | I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. Th... | Inclusion Criteria:
- Cases with severe insect sting allergy reactions
Exclusion Criteria:
- Without other severe systemic diseases
- Not pregnant or lactation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| The Causative Insects in Severe Insect Sting Allergy | NCT02764242 | Entailment |
4,243 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
-azoospermic patients
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
| Obtaining Undifferentiated Cells From Testis Biopsy | NCT01375062 | Entailment |
5,533 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Healthy volunteer or
- Patient with a suspected diagnosis of GCA but found not to have GCA
- Recent diagnosis of GCA within 1 month or
- Suspected flare of GCA within one month
- Ability to provide written informed consent
Exclus... | Giant Cell Arteritis: Improving Use of Ultrasound Evaluation | NCT02523625 | Entailment |
3,200 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Diagnosis of primary Sjögren's syndrome (pSS)
- ESSDAI score ≥ 6 at screening visit
Exclusion Criteria:
- Secondary Sjögren's syndrome
Other protocol-defined inclusion/exclusion criteria may apply.
No condition on gender to be admitted to the t... | Safety, Pharmacokinetics, and Preliminary Efficacy Study of CDZ173 in Patients With Primary Sjögren's Syndrome | NCT02775916 | Entailment |
1,233 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- • All adult patients aged between18- 70 years presenting with pleural effusion in
association with a malignant disease.
- Patients with documented malignant pleural effusion ( i.e positive pleural fluid
for malignant cells on pleural flui... | Comparison of the Effectiveness of Povidone-Iodine Alone to Povidone-Iodine-Tetracycline Combination | NCT04039126 | Entailment |
3,335 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Women and men aged 18-60 years.
2. For women, having a BMI between 18.5 and 35 kg/m2 (both included); for men having a
BMI between 18.5 and 25 kg/m2 (both included).
3. Healthy as determined from the self-reported medical history or when a clinical
... | Effect of Tableware Visual Cues on Portion Control and Eating Rate | NCT03610776 | Contradiction |
2,607 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Age between 1 and 6 year-old
- ASA class 1 and 2
- Pediatric Inguinal hernia patients who are scheduled for elective laparoscopic
inguinal hernia repair
Exclusion Criteria:
- Allergy to local anesthetics or contraindication to u... | The Effect of Systemic Lidocaine Infusion to Postoperative Pain and Quality of Recovery After Laparoscopic Hernia Repair in Children | NCT02007330 | Contradiction |
2,970 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Possible, probable (clinically or laboratory) or definite ALS according to the revised
version of the El Escorial World Federation of Neurology criteria
- Disease duration more than 6 months and less than 3 years (inclusive). Disease onset
defined ... | Study of Rasagiline in Patients With Amyotrophic Lateral Sclerosis | NCT01879241 | Entailment |
6,778 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male; 12-65 years of age
- Subjects with severe hemophilia A
- Previously treated with factor VIII for a minimum of 150 exposure days
Exclusion Criteria:
- Inhibitors to FVIII (current evidence or history)
- Any other inherited o... | A Trial Investigating Safety and Efficacy of Treatment With BAY94-9027 in Severe Hemophilia A | NCT01580293 | Entailment |
4,212 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Male or Female between 55 and 80 years of age
- 30 year pack-history of smoking and are either current smokers or who quit during the
past 15 years.
- Individuals who are members of the World Trade Center General Responder Cohort or
Sub... | The Liver in the World Trade Center Health Program General Responder Cohort and Controls | NCT03858920 | Contradiction |
3,333 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. They are 55 years old or above, with no gender restriction. They are permanent
residents of Da-jie town and Jiu-zhi Township in Da-ming County.
2. Patients who meet one of the following:
A. Hypertension project group:
Primary hyperten... | A Real World Research: Comparison of Precision and Experience Therapy for Hypertension, Diabetes or Hyperlipidemias | NCT04660630 | Contradiction |
5,418 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Working at Covid 19 Pandemic Hospital
- Being at between 18 and 47 years old
- Having menstruation
Exclusion Criteria:
- Oral contraceptive users
- Pregnants
- Having malignancy
- Having primary amenorrhea... | Menstrual Cycle Characteristics of Healthcare Professionals | NCT04413058 | Entailment |
5,146 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Women aged 50 and older
- Lumbar spine BMD (L1 to L4) T score between 0 and -2.0
- At least 3 years postmenopausal
Exclusion Criteria:
- Prior low trauma hip or vertebral fracture
- Total hip or femoral neck T score of <-2.0
... | The Nitrate and Bone Study: Effects of Nitrates on Osteoporosis | NCT00252421 | Contradiction |
541 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Subject must be 18 to 50 years of age inclusive, at the time of signing the informed
consent.
- Subjects who are healthy as determined by the investigator or medically qualified
designee based on a medical evaluation including medical history, phys... | Effect of GSK3640254 on the Pharmacokinetics of a Combination Oral Contraceptive | NCT03984825 | Contradiction |
1,623 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
Both phases (includes focus groups- Phase 1)
- Black (race)
- Heterosexual
- Currently enrolled in high school
Pilot Test (Phase 2)
- Ability to participate in web-based videogame
- Willing to sit for at least 60 minutes (... | A Digital Intervention for HIV Prevention in Black Adolescent Girls | NCT04108988 | Contradiction |
2,170 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
1. Subjects who are at least 18 years of age but younger than or equal to 99 years of
age.
2. Subjects with gouty arthritis as determined by the ACR 1977 classification criteria
for gouty arthritis.
3. Subjects with one palpable tophus detec... | Elastography as Gouty Arthropathy Outcome (EGO) | NCT02471261 | Contradiction |
1,073 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
1. Index patients:
- Age ≤18 years
- written informed consent of parents/legal guardians
- diagnosis of primary cardiomypathy:
- DCM: left ventricular (LV) systolic dysfunction and dilatation greater than two
... | Risk Stratification in Children and Adolescents With Primary Cardiomyopathy | NCT03572569 | Contradiction |
3,156 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. Adult females and males between the ages of 18 -75, seeking treatments for Dry Eye
Disease Due to Meibomian Gland Dysfunction
2. Tear breakup time (TBUT) ≤10 s;
3. Evidence of meibomian gland (MG) obstruction, based on total MGS of ≤12 in lower
... | Clinical Evaluation of Safety and Efficacy of Radio Frequency (Forma Eye) Treatment for Dry Eye Disease Due to Meibomian Gland Dysfunction | NCT04120584 | Contradiction |
5,587 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
1. Male and female participants with the age of ≥18 and ≤ 60 years of age.
2. BMI of ≥25 - ≤ 35 kg/m2
3. Waist circumference:India: Men: > 94 cm (37 inches), Women: >80 cm (31.5 inches) USA:
Men: > 102 cm (40 inches), Women: >89 cm (35 inches)
... | To Assess the Efficacy of CitruSlim® on Body Composition as Well as Metabolic and Hormonal Factors in Overweight and Obese Individuals | NCT03973086 | Contradiction |
854 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Patients with osteoarthrosis of the PIP joints.
- Patients with sufficient bone quality for implantation of a non-cemented prosthesis.
This is estimated by the surgeon preoperatively.
- Informed written patient consent.
- Patients must r... | An RSA and DEXA Study on Migration of Proximal Interphalangeal (PIP) Joint Prostheses of the Hand | NCT00175188 | Entailment |
479 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Unexplained infertility (UI)
Exclusion Criteria:
- body mass index (BMI) ≥35 kg/m2,
- Follicle Stimulating Hormone >10 International Unit /Litter in early follicular phase,
- diagnosed cause of infertility, menstrual cycle irregularity,
... | Uterine Flushing With Human Chorionic Gonadotrophin and Unexplained Infertility | NCT03461601 | Contradiction |
5,378 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
1. Participant has a documented diagnosis of severe von Willebrand disease (VWD)
(baseline Von Willebrand factor: Ristocetin cofactor activity (VWF:RCo) less than (<)
20 International Units/Deciliter [IU/dL]) with a history of requiring substitution
... | rVWF IN PROPHYLAXIS | NCT02973087 | Entailment |
5,931 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Patients with typical symptoms of heartburn sensation, or acid regurgitation,or both
for at least 6 months.The symptoms were moderate or severe and at least three days a
week in 7 days prior to the enrollment,which can complicate with Atypical and
... | Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole | NCT02986685 | Contradiction |
2,963 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Age between 18 and 75 years
- Signed informed consent prior to the initiation of any study-specific procedures
- Familial or sporadic ALS/MND, defined as clinically possible, probable, or definite as
per the El Escorial criteria
- Relati... | Targeting Metabolic Flexibility in Amyotrophic Lateral Sclerosis (ALS) | NCT04788745 | Entailment |
789 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- primary osteoarthritis in the distal interphalangeal joint
- require surgical treatment
- patient aged 18 years and over
- signed written informed consent
Exclusion Criteria:
- posttraumatic osteoarthritis
- rheumatoi... | Silicone Arthroplasty vs. Arthrodesis in the Distal Interphalangeal Joint | NCT01740999 | Entailment |
4,879 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
1. Cases
- Healthy Volunteers
- Men and women> 18 years
- No known chronic treatment or pathology
- Absence of tobacco or alcohol
- Normal bone mineral density for age (Z-score> -2 and T-score> -2.5) and ... | Cushing's Osteoporosis Specificities | NCT03162068 | Entailment |
2,852 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- ALS and controls(lumbar puncture at our department)
Exclusion Criteria:
- <18 years
- Other CNS disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject mu... | sCD163 in ALS Patients | NCT02325375 | Entailment |
2,618 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Male athlete (performing sports ≥ 1x/week) with sports-related groin pain ≥ 4 weeks
- Age: 18 - 40 years
Exclusion Criteria:
- Prior assessment/treatment of one of the two examiners for the same complaint (<6
months)
- Prior sur... | Inter-examiner Reproducibility of Clinical Examination Tests for Athletes With Longstanding Groin Pain | NCT03842826 | Contradiction |
4,288 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
Part 1
- Male; healthy according to complete medical history, including the physical
examination, vital signs (blood pressure, pulse rate), 12 lead ECG, clinical
laboratory tests.
- Age: 18-45 years (inclusive) at the first screening visit
... | Repeat Doses of BAY 1817080 in Healthy Males & Proof of Concept in Chronic Cough Patients | NCT03310645 | Entailment |
2,715 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion criteria;
- Age > 18 years
- BMI (body mass index) 20-35
- ASA (American Association of Anesthesiologists Classification system for physical
status) I-III.
- Scheduled for elective laparoscopic inguinal hernia operation
Exclusion criteria:
... | Effectiveness of a Transmuscular Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair | NCT03023462 | Entailment |
6,480 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
-Moderate to severe persistent facial erythema associated with rosacea.
Exclusion Criteria:
- Greater than 3 inflammatory lesions on the face
- Current treatment with monoamine oxidase (MAO) inhibitors
- Raynaud's syndrome, narrow angle glaucoma,... | Efficacy and Safety of AGN-199201 in Patients With Persistent Erythema Associated With Rosacea | NCT02131636 | Entailment |
665 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- homozygous for C282Y
- currently treated with phlebotomy as maintenance therapy for at least 6 month
- ferritin level between 30-50 micog/L
- age 18 years an older
- weight more than 50 kg
- signed informed consent
... | Erythrocytapheresis Versus Phlebotomy as Maintenance Therapy in Hereditary Hemochromatosis (HH) Patients | NCT01398644 | Contradiction |
2,933 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
Main inclusion criteria:
1. Familial or sporadic ALS
2. Patient diagnosed with probable of definite ALS
3. Patient treated with a stable dose of riluzole (100 mg/day) for at least 30 days prior
to screening
Exclusion Criteria:
... | Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS) | NCT02588677 | Entailment |
1,080 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | - Children and adolescents (less than or equal to 21 years) with HCM who had been
evaluated in the Cardiology Branch, National Heart Lung and Blood Institute between
1977 and 2002. HCM was diagnosed by echocardiographic demonstration of a hypertrophied
non-dilated left ventricle ... | Identification of Risk Factors for Arrhythmia in Children and Adolescents With Hypertrophic Cardiomyopathy | NCT00753233 | Contradiction |
1,750 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Men and women 18 years and older
- Diagnosis of FD with either PDS or EPS as measured by Rome III Criteria
- Patients describing inadequate relief of dyspepsia symptoms
- Endoscopy performed in the last 3 years and negative for an organic cause for
... | Study to Evaluate Dietary Modification in Patients With Functional Dyspepsia. | NCT02863822 | Contradiction |
452 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Fresh IVF/ICSI cycle
- Antagonist down-regulation
- Signed informed consent
Exclusion Criteria:
- Other known reasons for impaired implantation (i.e. hydrosalpinx, fibroid distorting
the endometrial cavity, Asherman's syndrome, ... | REFRESH: Receptivity Enhancement by Follicular-phase Renewal After Endometrial ScratcHing | NCT02061228 | Contradiction |
893 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- patients age 50 or older who present with symptomatic primary osteoarthritis of the
knee
- daily pain for the previous 3 months
- analgesics usage at least once a week
- less than 30 minutes of morning stiffness
- WOMAC score... | Intra-articular Injection in the Knee of Adipose Derived Stromal Cells and Platelet Rich Plasma for Osteoarthritis | NCT03089762 | Entailment |
5,094 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Generally healthy, community-dwelling ambulatory post-menopausal women.
- Able and willing to sign informed consent.
- Age 60 to 89.
- Have osteoporosis defined as follows:
- BMD T-score of the lumbar spine, femur neck, total proximal fem... | Enhancing Osteoporosis Therapy: Can We Open the Anabolic Window? | NCT01166958 | Contradiction |
2,104 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- any patient referred to the Interstitial Lund Disease clinic who is undergoing
evaluation and or treatment for a new diagnosis of ILD. This can include patients
referred for presumed pulmonary fibrosis/interstitial pneumonitis (IPF, UIP, NSIP),
sa... | Idiopathic Pulmonary Fibrosis Registry for Future Studies | NCT00815711 | Entailment |
3,944 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Voluntary signature of the IRB approved Informed Consent
2. Unilateral or bilateral osteoarthritic male or female ages 35-85
3. Pain, swelling, and/or functional disability in the affected knee consistent with
osteoarthritis in the knee joint
... | Correlating the Osteoarthritic Knee Microenvironment to Clinical Outcome After Treatment With Regenexx®SD Treatment | NCT02848027 | Entailment |
2,663 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Informed consent
- Age 18 years or older
- Diagnosis of reducible incisional hernias up to 200 cm²
- Medically fit for general anesthesia
- Comprehension and use of French language
- Installed in the geographical region withou... | Functional Outcome After Incisional Hernia Repair: Open Versus Laparoscopic Repair | NCT00625053 | Entailment |
5,082 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Members of the Henry Ford Health System
Exclusion Criteria:
- Individuals who are not members of the Henry Ford Health System
Female
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.
Subject must be at most 89 Years | Osteoporosis Disease Management Demonstration Project (0000-037) | NCT00139425 | Contradiction |
4,311 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Severe male factor infertility, Average response to COH,
Exclusion Criteria:
- Poor responders,
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years | Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility? | NCT02992665 | Entailment |
2,259 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Body weight ≥7.5 kilograms (kg)
- No clinically significant abnormality based upon laboratory assessments during the
screening period, in the opinion of the Investigator; good general health, as
determined during the screening period by medical his... | A Study to Evaluate the Safety and Pharmacokinetics of Ataluren in Participants From ≥6 Months to <2 Years of Age With Nonsense Mutation Duchenne Muscular Dystrophy (nmDMD) | NCT04336826 | Contradiction |
897 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Able and willing to give informed consent and comply with the study protocol.
- Symptomatic OA of the knee greater than 3 months, as defined by the American College
of Rheumatology's Clinical Criteria for Classification and Reporting of OA of the
K... | Using Pressure Detecting Insoles to Reduce Knee Loading | NCT02955225 | Entailment |
2,645 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- All laparoscopic TEP and TAPP repairs that have been registered in the SHR from
January 1, 2005 until December 31, 2017.
Exclusion Criteria:
- Open repairs.
- Hernioplasties that were converted from laparoscopic to open surgery.
... | Mesh and Mesh Fixation in Laparoscopic Groin Hernia Surgery | NCT03755219 | Entailment |
300 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
The inclusion criteria for RIF group were:
•unexplained repeated implantation failure (RIF) which is defined as the absence of a
gestational sac on ultrasound at 5 or more weeks after embryo transfer (ET) after 3 embryo
transfers with high quality embryos or after t... | Personal FET in RIF Patients According to Histological Dating of Endometrial of Natural/ Hormone Replacement Cycle | NCT03312309 | Contradiction |
2,385 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Subject Inclusion Criteria
1. Age: 5 - 11 years old
2. Ambulant
3. Diagnosis of DMD confirmed by at least one the following:
- Positive X-linked family history for typical Duchenne muscular dystrophy in older
male relatives (onset by age 5 yr., wheelch... | An Open-label Pilot Study of Coenzyme Q10 in Steroid-Treated Duchenne Muscular Dystrophy | NCT00033189 | Entailment |
2,931 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Have the ability to understand the requirements of the study, provide written informed
consent, understand and provide written authorization for the use and disclosure of
Protected Health Information (PHI) [per Health Insurance Portability and
Acc... | Dose Escalation and Safety Study of Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis | NCT01730716 | Entailment |
6,546 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Able to provide informed consent and comply with requirements of the study
- Males ≥18 y.o. with confirmed diagnosis of hemophilia B (≤2 IU/dL or ≤2% endogenous
factor IX)
- Received ≥50 exposure days to factor IX products
- A minimum av... | A Gene Therapy Study for Hemophilia B | NCT02484092 | Contradiction |
3,051 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
1. Confirmed genetic diagnosis of Fragile X (FraX) (full mutation).
2. Male (who have more serious effects due to the X chromosome nature of the disorder)
3. Age 13-29 years.
4. Parent of adolescent must be willing to sign informed consent.
5. I... | Double-blind Placebo Controlled Study of Oxytocin in Fragile X Syndrome | NCT01254045 | Entailment |
4,878 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Key Inclusion Criteria:
1. Male or female ≥18 years of age
2. Able to provide written informed consent prior to any study procedures being
performed; eligible subjects must be able to understand the informed consent form
prior to inclusion into the study.
3. Co... | Treatment for Endogenous Cushing's Syndrome | NCT01838551 | Entailment |
6,482 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. The subject has papulopustular rosacea with an Investigator Global Assessment (IGA)
score rated 3 (moderate) or 4 (severe),
2. The subject has at least 15 but not more than 70 inflammatory lesions (papules and
pustules) on the face.
Exclusi... | Phase 3 Papulopustular Rosacea Study | NCT01494467 | Entailment |
5,889 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Subject is between 18 - 80 years of age.
2. Subject underwent a sleeve gastrectomy minimum one year prior to enrollment (in order
to have reached a stable weight loss plateau).
3. Subject has a history of heartburn, regurgitation or both for >6 month ... | An Investigation of Electrical Stimulation on Gastroesophageal Reflux Disease (GERD) in Patients After Sleeve Gastrectomy | NCT02210975 | Contradiction |
3,402 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
Inclusion criteria for enrolment at birth
- Written informed consent obtained from the parents or guardians of the subject.
- A male or female infant born after a normal gestation period (between 36 and 42
weeks).
- Born to a mother seronegat... | Immunogenicity and Safety of Primary and Booster Vaccination With DTPa-HBV-IPV/Hib Vaccine | NCT00880477 | Contradiction |
2,389 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Young man ou woman (5 to 17 years old) with Duchenne Muscular Dystrophy (confirmed by
immunohistochimy on the muscular biopsy and/or mutation in the dystrophin confirmed by
molecular biology)
- Time more than 7 secondes to test of 10 m and/or dista... | Biomechanical and Morphological Changes in Dystrophic Muscle | NCT02472990 | Entailment |
6,149 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Age ≥50 years old OR primary healthcare professional (defined as having a job that has
had direct patient contact during the COVID-19 pandemic) and ≥18 years old
- No symptoms of COVID-19 (a fever of 100.0o F or greater, OR a new cough, OR new
shor... | Zinc Versus Multivitamin Micronutrient Supplementation in the Setting of COVID-19 | NCT04551339 | Contradiction |
1,379 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Less than 2 per week defecation
- Fecal incontinence
- Retentive behavior
- Pain at defecation and
- Hard stools
Exclusion Criteria:
- Medication use (calcium, antacid, diuretic and hematinic)
- Organic ca... | Physiotherapeutic Intervention in Children With Chronic Functional Constipation | NCT00906971 | Contradiction |
1,390 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
1. Age<14 years
2. Hirschsprung's disease diagnosed by biopsy
3. Surgical indication
Exclusion Criteria:
1. Age>14 years
2. Not Hirschsprung's disease
3. Surgical contraindication
No condition on gender to be admitted to the ... | Comparison of Circular(Soave) and Heart-shaped Anastomosis in Hirschsprung's Disease: A Prospective Multicenter Randomized Controlled Trial | NCT02234219 | Entailment |
4,523 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Healthy female volunteers
- Age: 18 - 35 years (inclusive), smokers must not be older than 30 years at inclusion
- History of regular cyclic menstrual periods (with a cycle length between 25 and 35
days)
- Willingness to use barrier meth... | Cycle Control and Safety of E2-DRSP | NCT00653614 | Contradiction |
1,561 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Age > 18 years
- Post-operative cardiac surgery patients on the ICU floors at the Cleveland Clinic Main
Campus
- Wrist size range ranging from 16 cm to 19 cm
Exclusion Criteria:
- Wrist size range smaller than 16 cm or larger th... | A Pilot Study to Assess the Accuracy of Blood Pressure Assessment by the Omron HeartGuide Smartwatch | NCT03986281 | Contradiction |
4,870 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
1. Has a confirmed diagnosis of endogenous Cushing's syndrome.
2. Requires medical treatment of hypercortisolemia.
3. Meets at least one of the following criteria:
1. Has type 2 diabetes mellitus.
2. Has impaired glucose tolerance.
... | Study to Evaluate CORT125134 in Participants With Cushing's Syndrome | NCT02804750 | Entailment |
4,103 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | INCLUSION CRITERIA
- Have signed & dated informed consent before beginning protocol procedures.
- Willing & able to complete entire trial as described in protocol.
- 16 years of age or older.
- Have a history and presenting symptoms of excessive daytime sleepiness.
... | Safety and Efficacy of Xyrem Oral Solution (Sodium Oxybate) Compared With Placebo in Narcoleptic Patients | NCT00049803 | Entailment |
3,311 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
- Age 3 to 60 years with albinism
Exclusion Criteria:
- Glaucoma or at increased risk of glaucoma
- History of dystonia
- History of melanoma
- Planning to undergo eye muscle surgery during study time frame
- Undergoing... | Trial of L-DOPA as a Treatment to Improve Vision in Albinism | NCT01176435 | Entailment |
5,618 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Obese or overweight at screening defined as: BMI greater than or equal to 30 kg/m2 and
<50 kg/m2 or BMI greater than or equal to 27 kg/m2 and <50 kg/m2 in the presence of
controlled hypertension and/or treated or untreated dyslipidemia. For patients
... | A Study of the Safety and Effectiveness of JNJ-16269110 (R256918) in Overweight and Obese Patients | NCT00622765 | Contradiction |
6,103 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Age >18 at the time of informed consent
2. Able to understand and provide informed consent in either English or Spanish
3. At high risk for COVID-19 disease progression by fulfilling at least ONE of the
following criteria at Screening:
... | Phase 2 Trial to Evaluate Safety and Efficacy of CYTO-205 in Mild COVID-19 | NCT04708327 | Contradiction |
6,056 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- 18 years of age
- Capable of giving informed consents.
- Cases of NERD will be recruited on the basis of presence of heartburn and/or
regurgitation using two validated GERD questionnaires in conjunction with an abnormal
esophageal pH re... | Diagnosis of Acid Reflux Disease Using Novel Imaging: A Prospective Study | NCT02081404 | Entailment |
3,110 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. Age: 40-85 years, visual acuity better than logMAR of 1.0
2. Chief complaint should be dry eye
3. Symptoms:
3.1. SPEED score > 6
3.2. TCM score satisfies lung-kidney yin deficiency profile
4. Signs:
4.1. TBUT (<10s) ... | Randomised Research Comparing Acupuncture, Herbal Treatment and Artificial Tear Eye Drops in Dry Eye | NCT02219204 | Contradiction |
5,127 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- They were required to have reduced bone density but no evidence of osteoporosis or
osteopenia by Dual-emission X-ray absorptiometry (DEXA) scan (T ≥ -1.0 in the lumbar
spine).
- Perimenopausal women : aged 40-70
Exclusion Criteria:
... | A 12-week Human Trial to Compare the Efficacy and Safety of Polycan on Bone Metabolism | NCT01402115 | Contradiction |
5,387 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Women 18 years or older
- And with a diagnosis of dysfunctional uterine bleeding without organic pathology
- And with at least one of the following symptoms: prolonged, frequent or excessive
bleeding.
Exclusion Criteria:
- The u... | Efficacy and Safety Study for the Treatment of Dysfunctional Uterine Bleeding | NCT00307801 | Entailment |
5,593 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria (physicians):
- Consenting physicians from the Northwestern Memorial General Internal Medicine (NMFF
GIM) practice
Exclusion Criteria (physicians):
- Study investigators will be excluded from participation (Dr. David Baker, Dr. Joyce
Tang)
... | Electronic Tools to Assist With Identification of and Counseling for Overweight Patients | NCT00973661 | Contradiction |
4,383 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Eligible subjects must have one of the conditions listed below and be enrolled in-person at
one of the participating clinical centers.Contact the study coordinator at the location
nearest you for more information about participation.
- Marfan syndrome
- Turner syndrome
... | National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions | NCT01322165 | Entailment |
6,174 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- patients presented by fever, myalgia or respiratory symptoms
- Close contact with a confirmed COVID-19 patient
Exclusion Criteria:
- pediatric patients
- patients refuse any of the following: MSCT chest, taking of nasopharyngeal swabs or
... | MSCT Chest in Suspected COVID-19 Patients | NCT04492865 | Contradiction |
4,940 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- A tremor syndrome of bilateral upper limb action tremor with at least 3 years'
duration
Exclusion Criteria:
- Patients who have decided not to receive DBS for control of their
medication-refractory essential tremor.
- Patients ... | Directional Versus Nondirectional DBS for ET | NCT04828798 | Entailment |
6,301 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Adult subjects (> 18 years old) with COVID 19 infection.The patients will be
classified on the basis of the severity of the disease.
Exclusion Criteria:
- -patients have symptoms of fever and /or respiratory with negative PCR for COVID-19.
No condition... | Immunogenetics Predictors With COVID-19 | NCT04390269 | Entailment |
4,979 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
1. Diagnosis of Essential Tremor based on the Tremor Investigational Group criteria for
definite or probable Essential Tremor.
2. Age: 18 years or over.
3. Willingness and ability to comply with the study requirements and give informed
conse... | Zonisamide in the Treatment of Essential Tremor | NCT00616343 | Entailment |
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