id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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630 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Iron overloaded male or female patients with primary or secondary hemochromatosis
- Age: 4 years and older
- Patients with desferrioxamine toxicity or allergy (e.g. visual or hearing defects,
bone abnormalities, reactions at injection site)
... | Study Using Deferiprone Alone or in Combination With Desferrioxamine in Iron Overloaded Transfusion-dependent Patients | NCT00349453 | Contradiction |
4,485 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. B-ultrasound or magnetic resonance imaging (MRI) examination confirmed that the
subject has adenomyosis, and the uterus is less than 10 weeks of pregnancy;
2. Visual analogue scale (VAS) of adenomyosis-associated pain> 0 points; with or without
meno... | Evaluation of Therapeutic Effect and Safety of Mifepristone in the Treatment of Adenomyosis | NCT03520439 | Contradiction |
1,790 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Early gastric cancer with biopsy confirmed high grade dysplasia or adenocarcinoma
(intestinal type)
2. Preoperative investigation with magnifying endoscopy and / or EUS predicted to be
mucosal lesion
3. Any tumor size if the early gastric... | Prospective Randomized Trial Comparing Endoscopic Submucosal Dissection Against Laparoscopic Assisted Gastrectomy for Treatment of Early Gastric Cancer | NCT03136354 | Contradiction |
1,223 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. Patients with recurrent symptomatic pleural effusion, the diagnosis was obtained by :
- positive cytology for malignant cells in the fluid.
- patients well known for malignancy, with exudative pleural effusion with no
alternative diagnosi... | Management of Malignant Pleural Effusion - Indwelling Pleural Catheter or Talc Pleurodesis | NCT02825095 | Entailment |
229 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. RIF patients (RIF is defined as the absence of a gestational sac on ultrasound at 5 or
more weeks after 3 embryo transfers with high quality embryos or after the transfer of
≥10 embryos in multiple transfers);
2. Out of phase dating patients;
... | Personalized FET in RIF Patients With Displaced Dating | NCT03910582 | Contradiction |
876 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
Inclusion Criteria for Erosive Hand OA
- Subject is a male or female between 40-80 years of age (inclusive) at the time of
signing the informed consent form.
- Subject meets the American College of Rheumatology (ACR) classification of
osteoa... | Subject Insights to Understand the Hand Osteoarthritis (HOA) | NCT03271203 | Entailment |
4,162 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Patients (including obstructive azoospermia and non-obstructive azoospermia) in need
of sperm retrieval (PESA, TESE) for ICSI.
Exclusion Criteria:
- Have not finished the process of sperm retrieval techniques.
- Malformation of genital orga... | The Acceptance, Safety, and Efficacy of MadaJet Versus Needle Injection for Sperm Retrieval in Patients With Azoospermia | NCT03181243 | Contradiction |
6,472 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Male or female research participants aged 18 or higher.
2. Patients with chronic persistent facial erythema (at least 1 month before baseline
[Day 1 hour 0]) of rosacea (with no restrictions to subtypes of rosacea), or
originated from other dermatol... | A Multicenter, Open-label Clinical Trial to Evaluate the Efficacy and Safety of Once Daily Mirvaso® Gel in Patients With Chronic Persistent Vascular Facial Erythema. | NCT02856919 | Entailment |
4,476 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
1. Participant in the Discovery Elbow Multi-center Study
2. Consent to participate in the Discovery Elbow Long-Term Survivorship Study
Exclusion Criteria:
1. Patient is not a Discovery Elbow Multi-center Participant
2. Patient does not provide con... | Discovery Elbow Long-Term Survivorship | NCT01308463 | Entailment |
283 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- A positive pregnancy test result.
- Single intrauterine pregnancy.
- Gestational age by last menstrual period of 6-10 weeks in patients with regular cycles
and sure of her last menstrual period date.
- History of recurrent pregnancy loss... | Ultrasound Predictors of Early Pregnancy Failure in Patients With Recurrent Pregnancy Loss | NCT03178682 | Contradiction |
3,443 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Age 18-70
- Body weight recorded in EHR in the prior month from a primary care setting.
- Last BMI in EHR either ≥30 kg/m2 or between 25.0-29.9 kg/m2 with documented
weight-related comorbidity (hypertension, type II diabetes, pre-diabetes,
... | Preventing Weight Gain Among Those Who Decline Behavioral Weight Loss Treatment (STEADY) | NCT04751656 | Entailment |
3,367 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Participants aged 18 to 74 years (inclusive) at screening.
2. Provision of signed and dated written informed consent (with the exception of consent
for genetic and non-genetic research) prior to any study specific procedures.
3. Body mass index (BMI) ... | A Study to Evaluate the Safety and Tolerability of MEDI0382 in Overweight and Obese Participants With Type 2 Diabetes Mellitus | NCT03745937 | Contradiction |
4,799 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
1. Persistent subjective peripheral tinnitus (unilateral or bilateral) following
traumatic cochlear injury (acute acoustic trauma, blast trauma, middle ear surgery,
inner ear barotrauma, tympanic membrane trauma) or otitis media with onset no longer
... | AM-101 in the Treatment of Acute Tinnitus 2 | NCT01803646 | Entailment |
5,014 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Patients diagnosed with ET by the Consensus Statement on the Classification of
Tremors,From the Task Force on Tremor of the International Parkinson and Movement
Disorder Society.
Exclusion Criteria:
- Lack of capacity to consent to partici... | Chinese ET Registry (CETR) | NCT04198246 | Entailment |
5,571 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Both sexes, more than 20 years and less than 70 years old patients with overweight
(BMI>27) or obesity (BMI<35). Available for a spa treatment during 18 days, and a
follow-up period of 14 months
- Voluntary to participate to the study,informed cons... | Maâthermes: Spa Treatment for Overweight and Obesity | NCT01258114 | Contradiction |
4,063 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- people aged 45 years or more
- subjects diagnosed with knee OA according to the clinical criteria of the American
College of Rheumatology
- subjects diagnosed with grade II or III OA during radiologicalexamination as defined
by the radi... | Radial Versus Focused Extracorporeal Shock Wave in the Treatment of Knee Osteoarthritis | NCT03921749 | Entailment |
6,723 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patient must be above 21 and below 60 years of age
- Patient must be of ASA I or ASA II classification
- Patient who requires single tooth extraction
- Patient whose tooth to be extracted is bounded by adjacent teeth
- ... | 3D Printed Scaffold Device for Ridge Preservation After Tooth Extraction | NCT03735199 | Contradiction |
3,317 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | - ELIGIBILITY CRITERIA:
To participate in this screening study, a patient must have a history of anterior segment
disease. Patients of all ages are eligible.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Screening for Research Subjects With Anterior Segment Diseases | NCT00088348 | Entailment |
2,997 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
Inclusion criteria for 3RP intervention:
1. Being the parent of at least one elementary school aged child with a diagnosed
specific learning disability
2. Age 18 or older
Exclusion Criteria:
Exclusion criteria for participation in 3RP gro... | Development of a Resiliency Training Program for Parents of Children With Specific Learning Disabilities | NCT02772432 | Contradiction |
6,780 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Adult patients (≥ 18 years of age) suffering from mild (FVIII or IX >5 %), moderate
(FVIII or IX 1-5 %) or severe (FVIII or IX <1 %) haemophilia A or B
- Submitted written consent to participate in the study
Exclusion Criteria:
- Patients s... | Osteoporosis and Haemophilia | NCT04524481 | Entailment |
6,213 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patient with clinical symptomatology suspecting COVID-19, that is to say: severe
dyspnea, and/or serious extra pulmonary signs (myalgia, diarrhea, etc.) OR
- Patient with clinical symptomatology (cough or dyspnea or fever with ENT signs) AND at
lea... | Risk Factors Worsening COVID19 for Out-patient With Home Monitoring | NCT04380662 | Contradiction |
1,853 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- age = 18 years old
- patients carrying a adenocarcinoma of the stomach or cardia histologically proven
- locally advanced tumour which may not be treated surgically or metastatic tumour
- the patients having a stenosante tumour responsible for a disp... | Metastatic Gastric Cancer FFCD 03-07 | NCT00374036 | Entailment |
1,176 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Clinical diagnosis of pleural effusion
- Pleural effusion proved by chest sonography
Exclusion Criteria:
- Conditions for which thoracentesis are contraindicated
- Pregnancy
No condition on gender to be admitted to the trial.
No healthy subj... | Use of Procalcitonin in the Diagnosis of Pleural Effusion | NCT00172835 | Entailment |
810 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- ACR criteria: knee pain and one of the tree following conditions: Age > 50 years,
Morning stiffness< 30 minutes and articular crackling.
- osteophytes visible on knee radiography.
- knee radiography less than 3 years old: face, schuss, axial of knee... | THERMARTHROSE: Gonarthrosis and Water Cure | NCT00348777 | Entailment |
223 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Documented diagnosis of primary hypogonadism (congenital or acquired) or
hypogonadotropic hypogonadism (congenital or acquired).
2. Serum total testosterone < 300 ng/dL based on 2 consecutive blood samples
Exclusion Criteria:
A subject will not... | Safety and Efficacy of Oral LPCN 1021 in Men With Low Testosterone or Hypogonadism | NCT02081300 | Entailment |
1,821 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Histologically confirmed primary adenocarcinoma, poorly differentiated carcinoma, or
carcinoma not otherwise specified, of stomach or gastro-esophageal junction.
2. T2-4 N0-3 M0. T1 tumors are eligible if T1N1-3
3. Disease must be clinically limited t... | Perioperative Chemoradiotherapy for Potentially Resectable Gastric Cancer | NCT00420394 | Entailment |
3,364 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Adult patients (male or female) aged over 16 years of age presenting to NHS ENT and
hearing services with SSNHL AND
- Diagnosed with a hearing loss in one or both ears of 30 dB HL or more, over at least 3
contiguous frequencies, between 250, 500, 1... | The SeaSHeL National Prospective Cohort Study | NCT04108598 | Contradiction |
3,435 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- patients with type 2 or type 1 diabetes or stress hyperglycemia
Exclusion Criteria:
- age <18,
- patients hospitalized for diabetic complications: ketoacidosis, hyperosmolar syndrome,
hypoglycemic coma, pregnant diabetics or gestational dia... | Governance of Diabetes Management in Non-specialistic Hospital Settings | NCT02640768 | Entailment |
6,018 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
The patients to be included will be outpatients who meet all of the following criteria. No
specific gender is asked.
<For the observation period>
1. Patients who have "heartburn" 2 days a week or more during consecutive 3 weeks* prior
to pre-observat... | A Study of E3810 With Pre- and Post-Treatment pH Monitoring in Patients With Non-Erosive Gastroesophageal Reflux Disease | NCT00165672 | Entailment |
4,728 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- women with indication for hysterectomy for a supposed benign uterine disease
- women with an age of 18 years or older
- women who were not pregnant at the time of presentation
- women who were appropriated medical status for laparoscopic surgery (Ame... | LESS-TLH Versus LESS-LAVH | NCT01861067 | Entailment |
242 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- at least one previous failed IVF cycle in which three or fewer follicles with a mean
diameter of 16 mm were achieved, and/or
- serum E2 level measured on the day of hCG administration was ≤500 pg/ml
Exclusion Criteria:
- day 3 serum FSH lev... | Antagonist/Letrozole in Poor Responders | NCT00823004 | Contradiction |
118 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Subject must be a male between the ages of 18 and 50 years.
- Subject must have localization-related epilepsy with complex partial and/or secondary
generalized seizures.
- Subject will meet criteria for hypogonadism (abnormally low bioactive testost... | Treatment of Sexual Dysfunction in Hypogonadal Men With Epilepsy With Testosterone and Either Anastrozole or Placebo | NCT00179517 | Contradiction |
6,869 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Age 55 or greater
- Good physical health
- Memory impairment with a diagnosis of mild cognitive impairment (MCI) or Alzheimer's
disease (AD)
- Participants on stable doses of Memantine (Namenda) or cholinesterase inhibitors will
... | SNIFF 120: Study of Nasal Insulin to Fight Forgetfulness (120 Days) | NCT00438568 | Contradiction |
6,164 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:s
1. Recipients:
We will use the confirmed case definition of SARS-CoV-2 infection (COVID-19) with
POSITIVE rRT PCR test for SARS-CoV-2 "using one of the SFDA approved kit used in KSA"
as per current MOH / SCDPC (Waqayah) guidelines (derived from WHO... | Potential Efficacy of Convalescent Plasma to Treat Severe COVID-19 and Patients at High Risk of Developing Severe COVID-19 | NCT04347681 | Contradiction |
4,374 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Subjects with normal eyes who are not using any ocular medications.
- Be of legal age of consent and sign Informed Consent document. If under legal age of
consent, legally authorized representative must sign Informed Consent document and
subject mu... | Prospective Study of an Investigational Daily Disposable Contact Lens | NCT01295905 | Entailment |
147 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Abnormal serum ALT on >2 occasions over at least 3 months, despite standard lifestyle
advice when appropriate, in regard to moderation of alcohol intake, weight reduction
and exercise.
- Negative serological tests for hepatitis Bs ag and C antibody... | Testosterone Replacement in Non-alcoholic Steatohepatitis (TEREPINS) | NCT01919294 | Contradiction |
4,429 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Men or women aged 16 to 60 years of age
- Displaced, distal humerus fracture (OTA 13A or 13C) as seen in radiographs
- Fractures ≤ 28 days post injury
- Closed fractures
- No history of previous ulnar neuropathy or elbow pathology
... | Simple Decompression Versus Anterior Transposition of the Ulnar Nerve | NCT01051869 | Contradiction |
939 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Patients must consent in writing to participate in the study by signing and dating an
informed consent document
2. Patients who can communicate (exclusion of anyone who cannot understand the
questionnaire)
3. between 20 years and 80 years... | Investigator Initiated Trial to Evaluate the Efficacy and Safety of Intra-articular Injection of ADMSC Comared to Negative Control After High Tibial Osteotomy in the Osteoarthritis Patients. | NCT03000712 | Entailment |
1,423 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Older adults living independently;
- medical approval.
Exclusion Criteria:
- Non-smokers;
- Non-morbidly obese;
- No history of severe hypertension;
- No history of falls;
- No orthopaedic, neurological, p... | Study of the Long-term Effects of Exercise on Heath Indicators in Older People | NCT01874132 | Contradiction |
873 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Postmenopausal women.
2. WOMAC pain score ≥ 50 on at least 1 of the 5 questions in pain subscale (range of 0 to
100, with higher scores indicating greater pain.
3. English literacy.
4. Able to undergo an MRI scan
5. Diagnosed Hav... | Tai Chi for Knee OA Pain Management: a Mechanistic Study | NCT04046003 | Entailment |
4,417 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Clinical diagnosis of lateral epicondylitis
- be aged ≥18 at the time of diagnosis
- be give informed consent
Exclusion Criteria:
- be have not completed the assessment process.
- elbow deformity
- psychological illne... | The Effects of Radial and Focused Extracorporeal Shock Wave Therapies on Lateral Epicondylitis | NCT04838002 | Contradiction |
709 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Male & female aged ≥ 40 to ≤ 65 years suffering from knee joint pain for at least 3
months prior to screening.
- BMI ≥ 18.5 and ≤ 29.9 kg/m2.
- Non-vegetarians (Regardless of whether they eat chicken, fish, goat mutton, pork, beef
or eg... | To Assess the Efficacy of Collagen Supplement in Osteoarthritis | NCT04470336 | Contradiction |
6,540 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients with diagnosis of hemophilia A, independent of age, treated with KOGENATE FS
as their only source of FVIII, decision taken by the investigator to administer
KOGENATE FS. For pretreated patients with more than 100 exposure days an inhibitor
... | EffeKt Taiwan- Efficacy and Safety of Long-term Treatment With KOGENATE® FS in Taiwan | NCT00932555 | Contradiction |
5,597 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion criteria
- Attending grade 9 or 10 in one of the 35 state-run school of the Vosges department and
be in a general, technological or vocational course,
- Aged ≤ 18 years old,
- not giving written refusal to participate in the trial,
- able to complet... | Overweight Management and Social Inequalities | NCT01688453 | Contradiction |
2,302 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Established clinical diagnosis of DMD and documented dystrophin gene mutation of DMD
phenotype.
- Indication of symptomatic muscular dystrophy by protocol-specified criteria.
- Ability to cooperate with motor assessment testing.
- Stable... | A Randomized, Double-blind, Placebo-controlled Study of SRP-9001 for Duchenne Muscular Dystrophy (DMD) | NCT03769116 | Contradiction |
3,749 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. age between 50~75 years old
2. diagnosis of osteoarthritis: The Clinical/Radiographic classification criteria of
American College of Rheumatology, ACR
3. chronic knee pain over 3 months.
Exclusion Criteria:
1. the past history with... | The Efficacy of TGF for Treating Osteoarthritis of the Knee | NCT03562429 | Contradiction |
2,638 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Male patients with a primary symptomatic unilateral inguinal hernia.
- Patients eligible to undergo hernia repair either by minimally invasive (TEP, TAPP) or
open techniques (e.g. Lichtenstein) as judged by the treating surgeon
- Written informed co... | Mesh Position and Outcomes Following Inguinal Hernia Repair Using an MRI Visible Hernia Mesh | NCT02770703 | Entailment |
1,148 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | INCLUSION CRITERIA:
Children of either gender, aged 4 to 18 years.
Obstructive HCM defined as LV hypertrophy, and an LV intra-cavitary pressure gradient
measured at cardiac catheterization of greater than or equal to 30 mm Hg at rest or greater
than or equal to 50 mm Hg following isopr... | Studying the Effectiveness of Pacemaker Therapy in Children Who Have Thickened Heart Muscle | NCT00001960 | Entailment |
3,660 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- lumber pain, pain radiating to leg, motor deficits in legs, , dural signs and
symptoms, impaired nerve root mobility(straight leg raise and L3 stretch), back pain
effecting Quality of life, ODI score less than 30 and Limited range of motion .
Exclusio... | Cyriax Manipulation in Lumbar Derangement Syndrome | NCT04082065 | Contradiction |
3,662 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
1. Being 18 years or older;
2. Having current acute or sub-acute low back pain defined as pain that has not lasted
more than 16 weeks;
3. Minimum score of 30mm on a 100mm visual analog pain scale.
Exclusion Criteria:
Exclusion criteria ... | Comparison of Activator Manipulation Versus Manual Side Posture Manipulation in Patients With Low Back Pain | NCT00497861 | Contradiction |
4,792 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- tinnitus for more than 6 months
- sensorineural hearing loss
- normal otoscopy
Exclusion Criteria:
- conductive or mixed hearing losses
- A-r, A-d, B and C tympanograms
- tinnitus treatment in the last 6 months
... | Correlation Analysis of Hearing Thresholds, Validated Questionnaires and Psychoacoustic Measurements in Tinnitus Patients | NCT00976547 | Entailment |
3,600 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Women with menorrhagia
- 18-49 years of age
- Regularly occurring menstrual periods
Exclusion Criteria:
- History or presence of clinically significant disease or abnormalities that may
confound the study
- History o... | Efficacy and Safety Study of XP12B in Women With Menorrhagia | NCT00386308 | Contradiction |
3,882 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Knee pain on most days of the previous month
- At least moderate pain on two of the five WOMAC knee pain domains in the most painful
knee
- Knee pain present for longer than 3 months
Exclusion Criteria:• House-bound or care home resident
... | Knee Pain Nurse Led Package of CareTrial | NCT03670706 | Entailment |
2,971 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Sporadic or familial ALS diagnosed as clinically possible, probable, lab-supported
probable, or definite ALS defined by revised El Escorial criteria.
2. Age 18 years or older.
3. Capable of providing informed consent and complying with study procedure... | HEALEY ALS Platform Trial - Master Protocol | NCT04297683 | Entailment |
6,064 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Post-prandial heartburn (e.g. after a high-fat meal) in at least 2 months prior to the
study (at least 2 times a week)
- Not receiving prescribed treatment for heartburn, reflux or upper gastrointestinal
disorders
- Written informed con... | Safety and Efficacy of IQP-LH-101 in Postprandial Heartburn | NCT01718639 | Entailment |
818 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Males and females between 40 and 75 years of age, inclusive
2. BMI between 18.5 to 29.9 kg/m2, inclusive
3. Female participant is not of child-bearing potential, defined as females who have
undergone a sterilization procedure (e.g. hysterectomy, bilat... | Safety and Efficacy of JointAlive™ on the Knee-joint Function in Adults With Knee Arthritis | NCT04395547 | Entailment |
1,243 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | DISEASE CHARACTERISTICS: Unilateral malignant pleural effusion requiring sclerosis (as
judged by the attending surgeon) At least 3 months since treatment of contralateral
effusion No chylous effusion
PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy:
... | Talc in Treating Patients With Malignant Pleural Effusion | NCT00002622 | Entailment |
1,327 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Adult individuals of either gender with achondroplasia and their first degree relatives
(both short and average statured) of all ethnic and cultural backgrounds.
No short-statured persons with conditions other than achondroplasia.
No average-statured family members of short statured persons wi... | Issues Surrounding Prenatal Genetic Testing for Achondroplasia | NCT00001536 | Contradiction |
137 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Men who are 65-90 years of age
- Total serum IGF-1 (insulin-like growth factor) in the lower tertile for adults (56-167
ug/dl)
- Total serum testosterone of 150-550 ng/dL
Exclusion Criteria:
- BMI (Body Mass Index) 35 kg/m2 or g... | HORMA: Hormonal Regulators of Muscle and Metabolism in Aging | NCT00183040 | Contradiction |
3,194 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. Patients with Sjögren's syndrome (Revised Japanese criteria for Sjögren's syndrome
(1999): 1998 research report on immunological intractable diseases specified by the
Japanese Ministry of Health and Welfare)
2. Patients aged 20 years or older at tim... | Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome | NCT00233363 | Entailment |
4,127 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
For all patients:
1. The patient understands the study procedures and agrees to participate by signing the
consent form.
2. The patient is male or female, at least 18 years of age but no more than 80 years of
age at the entry into the study (s... | Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease | NCT00555607 | Contradiction |
5,460 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- The study enrolled subjects who had completed the double-blind therapy in either the
XP12B-MR-301 or XP12B-MR-303 study, including scheduled evaluations, with no major
protocol violations and no study events that, in the opinion of the investigator,
... | A Study of Tranexamic Acid (XP12B) in Women With Heavy Menstrual Bleeding | NCT01280981 | Entailment |
65 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. Agrees to written as well as audio-visual informed consent.
2. Ability to understand the risks/benefits of the protocol
3. Male between 35-65 years of age.
4. Diagnosed with Symptomatic hypogonadism
Exclusion Criteria:
1. Uncooperati... | Evaluation of Furosap in Human Volunteers | NCT02748005 | Contradiction |
5,137 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Women
- Age ≥ 60 years
- Bone mineral density T-score of either the spine (L1-L4), total hip or femoral neck of
≤ - 2.0, or has a history of an osteoporotic fracture
Exclusion Criteria:
- Previous treatment with pamidronate, iba... | µMRI of Therapeutic Intervention in Postmenopausal Osteoporosis | NCT01153425 | Contradiction |
3,476 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Gender: men and women
2. Ethnicity: all ethnic groups
3. Age: ≥18, < 75 years
4. Diagnosis of T2D -A1C within the last 90 days must be >7.5%
5. Obesity, BMI ≥30
6. An Employee, or the significant other of an employee, that is cover... | EMI-EHP Weight Management and Type 2 Diabetes Pragmatic Trial | NCT04531176 | Entailment |
6,007 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Experiencing heartburn at least 2 days per week over the past month.
2. Having heartburn that responds to heartburn medication.
3. Be willing to discontinue the use of heartburn treatment for 7 days prior to inclusion
in the study.
Exclusion ... | Efficacy/Safety of Lansoprazole in Patients With Frequent Heartburn | NCT00390390 | Entailment |
3,256 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Sexually active 18-40 year old heterosexual couple
- Subject willing to take Mircette birth control pills for at least one cycle (one pack)
- Willing to have intercourse at the defined times (at least weekly within a 3 week
interval, and draw blood ... | Sexual Absorption of Vaginal Progesterone | NCT01959464 | Entailment |
792 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Age 19-65
- Grade I or II knee Osteoarthritis confirmed by radiographs or other imaging and at
least one of the following:
- Age > 50 years old
- Morning stiffness < 30 minutes
- Crepitus
- Meet at ... | Corticospinal Excitability and Rehab in Knee Osteoarthritis | NCT02036866 | Entailment |
5,742 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Of any gender, 18 years or older.
- With a diagnosis of oral lichen planus previously proven on biopsy.
- With at least one erosion at baseline (baseline IGA of 2 or greater).
- Signed written informed consent.
- Willingness and ability t... | Pimecrolimus Cream for Oral Lichen Planus | NCT00297037 | Contradiction |
1,183 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Male or female, at least 18 years of age, inclusive
- Subject has a symptomatic malignant pleural effusion requiring intervention. For an
effusion to be defined as malignant, at least one of the following must be true
- There is cytological con... | Management of Malignant Pleural Effusions Using an Indwelling Tunneled Pleural Catheter and Non-Vacuum Collection System | NCT03414905 | Entailment |
624 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
Left ventricular ejection fraction <40% assessed by transthoracic echocardiography or
cardiac magnetic resonance with at least 3 months.
- Serum ferritin < 100µg/L or 100-299µg/L with transferrin saturation < 20%
- clinical stability during last 3 months
... | Ferric Carboximaltose on Intra-myocardial Iron Load in Patients With Heart Failure | NCT03871699 | Contradiction |
915 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | No eligibility criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at most 100 Years | HYPGENE-Genetics Fitness Obesity & Risk of Hypertension | NCT00083811 | Entailment |
2,135 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
All participants who were allocated to the study all had a history of taking tolerable and
adequate dose of urate lowering therapy including febuxostat 40-80mg daily or allopurinol
200-300 mg daily for at least 4 weeks and were defined as difficult to treat or refractory
... | Immune Molecular and Inflammatory Cytokines Dysfunction Analysis in Gout Patients With Different Urate Levels | NCT02060552 | Contradiction |
2,579 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Bilateral congenital inguinal hernia Unilateral congenital inguinal hernia Hernia
defect siameter less than 1.5 mm
Exclusion Criteria:
- Recurrent hernia age less than 6 Month Contraindication to laparoscopy
Female
No healthy subjects accepted to join ... | Needlescopic Inversion and Snaring of Hernia in Girls | NCT04628455 | Contradiction |
5,413 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Women aged 18-50.
- Heavy menstrual bleeding, defined as self-report of bothersome periods with
subjectively heavy flow or frequency greater than 7 bleeding days per month.
- Anemia with hgb <11.5 g/dL
Exclusion Criteria:
- Susp... | IV Iron vs Oral Iron for Treatment of Anemia in Women With Abnormal Uterine Bleeding | NCT04205266 | Entailment |
3,215 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
Clinical Diagnosis of pSS healthy females who presented to the gynecology outpatient clinic
for reasons other than sexual dysfunction -
Exclusion Criteria:
Pregnancy hepatic, renal, interstitial lung, gynecological oncological diseases,
psychiatric disorder... | Effects of Primary Sjögren's Syndrome on Female Genitalia and Sexual Functions | NCT04816370 | Entailment |
4,001 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Adult > or = 55 years.
- Being monitored by a rheumatologist in private practice or in a hospital.
- Presenting nociceptive pain:
- chronic (for at least 3 months),
- secondary to knee osteoarthritis confirmed by x-ray: stage 2 ... | Comparison of the Efficacy, Tolerability and Safety of actiTENS to Those of Level 2 Analgesic Treatments. | NCT03902340 | Entailment |
3,812 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Willing and able to give full consent;
2. According with classification of "Clinical Image" of 1986 American college of
rheumatology criteria in osteoarthritis of the knee ;
3. Grade II-III of Kellgren-Lawrence (KL) grading system, revealing synovial ... | Efficacy of Intra-Articular Injection of Etanercept for Moderate and Severe Knee Osteoarthritis | NCT02722772 | Entailment |
4,187 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Men with azoospermia (Group 1) and proven fertile men undergoing vasectomy (Group 2)
Exclusion Criteria:
- Men with testicular abnormalities (Group 2)
- Men who do not understand the purpose and possible consequences of the study (both
grou... | HPV as a Possible Cause of Azoospermia | NCT02329275 | Contradiction |
5,801 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Healthy adults
- Age: 18-65 years
- Dutch-speaking
- Caucasian
Exclusion Criteria:
- Pregnancy or lactating
- Using ointment, crème, or gels based on corticoids
- Suffering from skin diseases (psoriasis, b... | Echographic Measurement of Skin Thickness | NCT02363465 | Entailment |
6,983 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria: Cohort 1: Older adults with memory impairment: must have a physician or
primary caregiver report of memory loss and must be between 50 and 100 years old.
cohort 2: Older adults who test normally on neuropsychologic testing and have no history of
neurologic disorders.
... | Diagnosis of Alzheimer's Disease Using Event Related Potentials | NCT02957227 | Entailment |
4,832 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:Children aged 4-16 years. Healthy population from selected kindergarten
and Schools, and patients refered to the obesity clinic Haukeland University Hospital, for
examination and optionally treatment.
-
Exclusion Criteria:Use of any kind of steroids ( oral, liniments... | Saliva Cortisol Measurement as a Screening Test for Suspicious Cushings Syndrome in Children. | NCT02646553 | Contradiction |
3,346 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Singleton uncomplicated pregnancy
- Reside in Darwin, the Tiwi Islands, or other remote community where consent has been
obtained
- Intends to deliver child at the Royal Darwin Hospital or other designated hospital
where consent has bee... | PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers | NCT00714064 | Contradiction |
5,557 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Female
- Bone age <12 years
- Karyotype: 45, X; 45, X / 46, XXqi; 45, X / 46, XXr; 45, X / 46, XX; 46, XXqi; 46,
XXpi; 45, X / 47, XXX; 46, XXp-; 45, X / 46, XXp-; 46, XXq-; 45X / 46, XXq-; 45, X /
46, XX / 47, XXX, etc. (count 50 or mo... | A Study of PEG-somatropin Injection to Treat Children of Turner Syndrome | NCT03189160 | Contradiction |
2,923 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- A diagnosis of familial or sporadic ALS (defined as meeting the possible,
laboratory-supported probable, probable, or definite criteria for a diagnosis of ALS
according to the World Federation of Neurology El Escorial criteria) ≤ 24 months prior
t... | Ventilatory Investigation of Tirasemtiv and Assessment of Longitudinal Indices After Treatment for a Year | NCT02496767 | Entailment |
4,813 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Age: 18≤ years ≤85
- Clinical diagnosis of chronic dizziness primary or secondary to vestibular disorder.
- Stable symptoms for more than one month and less than a year.
- Ability to perform all tests (including computerized test) and interviews.
... | Study to Assess the Efficacy and Safety of SpotOn Specs™ for the Treatment of Chronic Dizziness | NCT01460121 | Entailment |
4,148 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- age > 40 years; smoking history of 30 pack-years or more; normal organ function;
sputum atypia
Exclusion Criteria:
- general debility that would prevent completion of 6 month follow-up; existing cancer
diagnosis
No condition on gender to b... | A Phase IIb Trial of Pulmicort Turbuhaler (Budesonide) | NCT00175747 | Contradiction |
5,595 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Patients with extreme short stature will qualify for inclusion under this protocol if they
meet the following criteria:
Age 9 through 15.99 years at the start of treatment.
Tanner II-V pubertal development.
Height at least 2.25 S.D. below the median for chronologic age at the time of ... | Study of Luteinizing Hormone-Releasing Hormone Analog (LHRHa) in Pubertal Patients With Extreme Short Stature | NCT00001190 | Contradiction |
2,543 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | - INCLUSION CRITERIA:
Males and females, age 3 months to 19 years old, (less than 18 years old).
Individuals referred to the NIH with a diagnosis of asthma, rhinitis, anaphylaxis,
urticaria, atopic dermatitis, food allergy, stinging insect allergy or other
allergic/inflammatory diseas... | Clinical and Immunological Evaluation of Children With Allergies | NCT00102570 | Entailment |
4,077 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- Male and female subjects 18 to 65 years of age included.
- Confirmed diagnosis of SWD according to ICSD-3 criteria at Screening.
- Subjects who are at least moderately ill with respect to sleepiness on work nights,
including commute to and from work... | A Study to Assess the Wakefulness Promoting Effect, Safety, Tolerability, and Pharmacokinetics (PK) of LML134 in Shift Work Disorder | NCT03141086 | Contradiction |
5,647 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Have a chronological age > 4.0 years and < 8.0 years for girls and < 10.0 years for
boys.
- Have a minimum body weight of 17 kg at the time of screening.
- Have a bone age examination at screening or within the 6 months prior to screening
... | PK and PD Study of LUM-201 in Children With Growth Hormone Deficiency | NCT04806854 | Contradiction |
6,524 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Hemophilia A or B, with or without inhibitor, with unilateral or bilateral ankle pain
Exclusion Criteria:
- None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
| Comparison of Two Types of Ankle Braces in the Management of Ankle Pain in Hemophilia | NCT00972296 | Contradiction |
6,085 | 45 | A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is o... | My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor dia... | Inclusion Criteria:
Anyone 6 months to 89 years old who:
1. has Down syndrome (any type)
2. does not have Down syndrome
Exclusion Criteria:
1. Prisoners
2. Wards of the state
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subj... | The Crnic Institute Human Trisome Project Biobank | NCT02864108 | Contradiction |
1,920 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Histologically confirmed, resectable adenocarcinoma of the gastroesophageal junction
(AEG/GEJ-type II-III) or the stomach (uT2, uT3, uT4, any N category, M0), or any T N+
M0 patient, with the following specifications:
1. Medical and technical o... | FLOT vs. FLOT/Ramucirumab for Perioperative Therapy of Gastric or GEJ Cancer (RAMSES) | NCT02661971 | Entailment |
6,096 | 45 | A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is o... | My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor dia... | Inclusion Criteria:
- Down syndrome with psychological test results
Exclusion Criteria:
- Comorbidity of severe Autism or visual/auditory impairment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Months old.... | Trends in Intellectual Development in Down Syndrome | NCT00954382 | Entailment |
3,104 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
Ocular foreign body sensation, burning or stinging, complaints more pronounced in winter,
windy conditions, during computer work, being bilateral, of the duration longer than three
months, visual acuity fluctuations depending on blinking after longer reading or computer
... | The Effect of Ocular Lubricant Eyedrops on Lid Parallel Conjunctival Folds and Other Signs and Symptoms of Dry Eye | NCT01268735 | Contradiction |
2,088 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
1. Clinical symptoms consistent with idiopathic pulmonary fibrosis (IPF) of > 3 months
duration (insidious onset of otherwise unexplained dyspnea on exertion and bibasilar
inspiratory crackles)
2. Age 20 through 79, inclusive. Patients ages 20-34 must ... | Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study | NCT00203697 | Entailment |
675 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Age over 18
- Signed written informed consent
- Ferritin ≥ 450 µg/L and ≤ 1500 µg/L
- Hepatic iron overload proved by MRI or histological biochemical measurement (Iron
hepatic concentration ≥ 50 μmol/g)
- At least one of the ... | Phlebotomy and Lifestyle and Diet Advices vs Lifestyle and Diet Advices Only in Patients With Dysmetabolic Liversiderosis | NCT01045525 | Contradiction |
1,392 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Patient admitted for rectal biopsy, by clinical decision, so that Hirschsprungs
disease may be diagnosed or ruled out
Exclusion Criteria:
None
-
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
S... | Electrophysiological Activity of the Anorectum in Children Suspected of Hirschsprung Disease | NCT02342457 | Entailment |
6,719 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- 5-17 years of age, has a diagnosis of Hemophilia A or B.
Exclusion Criteria:
- Muscle or joint bleed within 4 weeks of study.
- Pre-existing co-morbidities that would affect physical activity participation.
- Unable to cooperate with study p... | An Institutional Pilot Study to Investigate Physical Activity Patterns in Boys With Hemophilia | NCT02199717 | Contradiction |
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