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age 11 predicted more likely alcohol abuse at age 27 in a study of Swedish children (Hawkins et al. 1997). Evidence of alcohol abuse was based on registration with the
Swedish Temperance Board, arrests for drunkenness, driving-while-intoxicated charges, or treatment for alcoholism. Measures of (poor) motor development in the first year of life related to the diagnosis of alcohol dependence
at age 30 in the Danish Longitudinal Study of Alcoholism (Manzardo et al. 2005). Motor development was measured by muscle tone at age 5 days, an inability to sit without
support at age 7 months, and the inability to walk at 1 year. Lower math achievement scores in 1st grade, lower ratings of shyness (boys only), and mother’s regular alcohol
use (both genders) predicted a diagnosis of adult alcohol abuse or dependence at age 42 in a followup of African-American children initially studied in the 1st grade as part of
the Woodlawn Study (Crum et al. 2006). Psychologist ratings of extroversion/aggression at age 4 correlated with frequency of intoxication at age 25, and ratings of extroversion/ outgoing correlated with lifetime
alcohol problems at age 36 in a Stockholm prenatal study (Wennberg and Bohman 2002). A conceptual model that integrates the following factors predicted DSM–IV alcohol abuse and dependence at age
21: internalizing disorders, externalizing disorders, male gender, delinquency, unclear family rules, poor family monitoring, less bonding to school, living in a neighborhood with more troublemakers, having antisocial friends, having friends
who drink frequently, bonding to antisocial friends, higher intentions to use alcohol, and more favorable attitudes toward alcohol at age 10 (Guo et al. 2001). ALCOHOL-SPECIFIC RISK FACTORS IN CHILDHOOD
FOR FUTURE ALCOHOL INVOLVEMENT A multilevel, dynamic interplay of biological, psychological, and social processes shapes normal development as well as risk for alcohol use. Research has identified a number of
factors in the 0–10 age-group that specifically predict risk for later alcohol use and alcohol use disorders (as compared with nonspecific risk factors that predict a spectrum of problems, including
alcohol use). A significant alcohol-specific risk factor is the age of initiation, especially of binge drinking. Childhood and early adolescent onset of alcohol use increases the likelihood of developing both
problem drinking in adolescence (Ellickson et al. 2003; Fergusson et al. 1994; Gruber et al. 1996; Hawkins et al. 1997) and alcohol abuse or dependence in adulthood (Grant and Dawson
1997; Hingson et al. 2006; Pitkanen et al. 2005). It is not yet clear, however, whether childhood alcohol use (i.e., at age 12 and under) or early adolescent alcohol use
(i.e., at age 13 or 14) is the greater risk factor. Early-onset drinking is related to a variety of problematic outcomes in addition to later alcohol involvement. Onset of drinking
by ages 10–12, for example, is correlated with absences from school, as well as marijuana and other illicit drug use in grade 12 (Gruber et al. 1996). Onset by ages
12–13 (7th grade) is related to more delinquent behavior, school problems, smoking, and illicit drug use in grade 12 and to smoking, illicit drug use, drug selling, and criminal behavior
at age 23 (Ellickson et al. 2003). A follow-up study in grade 10 found that those who initiated drinking by the fall of 7th grade reported more recent drinking, drunkenness,
and alcohol or drug problems and were more likely to have initiated sexual intercourse, to have had more than two sexual partners, and to have become pregnant or gotten someone
pregnant compared with those who had not started drinking (Stueve and O’Donnell 2005). Development of Children’s Beliefs and Expectancies1 About Alcohol[1Expectancy is a term commonly used in the alcohol research
literature to mean expectations.] As children develop, they become aware of alcohol as an object in their social environment through a variety of means. They observe alcohol use by parents
and other adults in the immediate social environment, they see drinking paraphernalia (i.e., bottles, cans, six-packs, special glasses for wine and cocktails, etc.) and experience the smell of alcohol in
its different forms. They also make observational contact via the media, seeing adolescent and adult actors on television, in movies, magazines, newspapers, advertising, and other forms of media. In the
absence of the actual drinking experience, observational learning about alcohol is the major influence in determining children’s attitudes toward alcohol and the expectations they have about the effects of drinking.
A number of studies show this influence is not inconsequential. As children grow older, they learn that alcohol produces changes in thinking, feeling, and behavior and that it has a
role in social relationships. They discover who uses it and why and, ultimately, develop expectations about its use. To a significant degree, these cognitive variables influence when they will consume
alcohol, how much they will drink, and when they will consider it appropriate to decline use. By preschool, children have learned certain norms about alcohol use, namely, that adults drink
alcoholic beverages, children do not, and men drink more than women (Zucker et al. 1995). By ages 6.5–7.5, children understand the concept of alcohol (Fossey 1994). Their attitude toward adults
depicted drinking alcohol basically is neutral at age 6 but becomes more negative through age 10 (Fossey 1994; Jahoda and Cramond 1972). Between ages 10 and 14, these attitudes shift
to become more positive (Aitken 1978). Children also learn about the behavioral effects of drinking and hold definite beliefs about it by age 10 (Fossey 1994; Gaines et al. 1988;
Miller et al. 1990). These expectations about the effects of alcohol on drinkers generally are negative in childhood (Noll et al. 1990), but they become more positive as the children
get older (Miller et al. 1990) and as they enter adolescence (Dunn and Goldman 1998). Childhood Social Contexts That Influence Drinking In this age-group, parents are the major source of
children’s exposure to alcohol use. Research over four decades consistently indicates that children are more likely to become drinkers at some point in their lives if their parents are drinkers.
Self-reports of alcohol use among children correlate significantly with their perceptions of parental drinking (Jackson 1997). In fact, even preschool children are aware in some way of their parents’ level
of drinking; this awareness translates into perceptions of the world as more or less peopled by adults who drink, such that 3- to 5-year-olds from heavier drinking homes are more
likely to think that, when adults drink, they will be drinking alcoholic beverages (Zucker et. al., 1995). The fact that these preschoolers see men as drinking more than women, implying
a personal knowledge of adult-cultural norms, suggests that even at very young ages, children have an acute understanding of the level of drinking around them. Thus, parents increase the likelihood
of their child’s drinking by modeling alcohol use, by making alcohol accessible in the home, by actively encouraging their child’s experimentation with alcohol, and also by covertly teaching them that
alcohol use is an acceptable, possibly even desirable, behavior. When children are asked to name the source of their first drink, they overwhelmingly cite their parents or their home. For
example, the 1993–1994 Bogalusa Heart Study found that 78 percent of the children in grades 3 through 6 who had ever tried alcohol took their first drink with someone in
the family (Johnson et al. 1997). A recent community survey of children in Oregon (Andrews et al. 2003) found that few of the children who had ever tried alcohol had
done so without their parents’ knowledge, especially in grades 1 through 4. Children, like adolescents, also learn about alcohol use and its effects through their exposure to its portrayed use
in movies, television, and advertisements. The alcohol industry spends over $1.6 billion a year on advertising, which it places in a variety of media, including radio, television, magazines, newspapers, and
billboards (Bonnie and O’Connell 2004). Because magazine and radio audience data do not include children under age 12, it is not possible to measure childhood exposure to alcohol advertisements in
these media. However, it appears likely that children under age 12 are less exposed to magazine ads because of their reading levels and their choice in reading materials. Generally, children
favor books over magazines, or if they read magazines they prefer those with advertising restrictions. The same situation appears to exist for television advertising. A July 2005 Center on Alcohol
Marketing and Youth report indicates that children ages 2–11 are exposed to less than half as many television alcohol advertisements as adolescents ages 12–20. As a result, they are underexposed
relative to their prevalence in the overall population (Center on Alcohol Marketing and Youth 2005). Nonetheless, they still are exposed to some television advertising of alcohol products. Children ages 2–11
saw an average of 99.4 alcohol advertisements on television between January and October of 2004. Of those advertisements, 81 percent were for beer and ale, 11 percent for spirits, 5
percent for alcopops, and 3 percent for wine. Assuming a similar exposure rate across the years, the average child would have seen almost 1,200 television advertisements for alcohol products before
the age of 12. In addition to alcohol advertisements, children are exposed to portrayals of alcohol use in G- and PG-rated movies and on television shows in which characters use
alcohol, often without apparent consequences. These programs are pervasive in primetime (8–11 p.m.) television when children may be watching. An estimated 71 percent of sampled primetime episodes from the 1998–1999
season portrayed alcohol use (Christenson et al. 2000). Approximately 38 percent of the TV-G–rated programs considered appropriate for most children depicted alcohol use. The majority of episodes characterized drinking as
a positive experience rather than a negative one, with adverse consequences portrayed or mentioned in only 23 percent of the episodes. Is childhood exposure to alcohol use in the media
important? Significantly more research is necessary to determine the relationship between media exposure to drinking and children’s initiation of alcohol use. However, a greater awareness of beer advertisements was significantly
related to greater intentions to drink as an adult in a study of 5th/6th-grade students (Grube and Wallach 1994). Awareness was defined as the ability to correctly identify brand names
of still photographs from current television commercials. A study of 10- to 14-year-old nondrinkers found that their level of exposure to alcohol use in motion pictures predicted whether they were
drinkers 1 to 2 years later (Sargent et al. 2006). Children in Alcoholic Families: A Special Early-Risk Population Approximately 9.7 million children age 17 or younger were living in households
with one or more adults who were classified as having a diagnosis of alcohol abuse or dependence within the past year, according to data from the National Longitudinal Alcohol Epidemiologic
Survey (NLAES) (Grant 2000). Approximately 70 percent of these children were biological, foster, adopted, or stepchildren. Therefore, 6.8 million children, or about 15 percent of children aged 17 or younger,
meet the formal definition of children of alcoholics (COAs). From the standpoint of socialization risk, these numbers reflect only acute exposure (i.e., within the past year) to at least one
alcoholic adult. According to additional data from the NLAES survey, 43 percent of the under-18 population, or slightly less than half of all children, were exposed to either a current
or previously alcoholic adult in their household at some time in their childhood. Approximately 30 percent of COAs under the age of 18 were similarly exposed, but even this represents
an enormous population at high risk.2 [2The apparent discrepancy between 43 percent of all children and 30 percent of children of alcoholics being exposed to an alcoholic adult in their
household is accounted for by a variety of factors, including parental divorce where the child lives with the nonalcoholic parent or child placement outside the home because of parental alcoholism.]
COAs have an increased risk for earlier drinking onset (Donovan 2004) and earlier progression into drinking problems (Grant and Dawson 1997). They are between 4 and 10 times as likely
as non-COAs to become alcoholics themselves (Russell 1990). Genetic Risk Factors. Studies of children with an alcoholic biological parent who were raised by nonalcoholic adoptive parents (e.g., Sigvardsson et al.
1996) make it possible to separate genetic and environmental influences on the development of alcoholism. In such studies, the adopted children with a biological alcoholic parent were significantly more likely
to develop alcoholism later in life than were control children without a genetic risk for alcoholism even though alcohol abuse had not been modeled in their home. Such studies indicate
a genetic risk for alcoholism. Additional research will be required to isolate the specific aspects of genetic risk that result in alcoholism and to identify environmental factors that moderate that
risk. Factors Involved in Familial Transmission. The increased risk of alcohol involvement experienced by COAs is attributable to the following: Genetically transmitted differences in response to alcohol that make drinking
more pleasurable and/or less aversive; The socialization effects of living in an alcoholic household; and Higher transmission of risky temperamental and behavioral traits that lead the COAs into greater contact
with earlier and heavier drinking peers. Thus, familial alcoholism is a proxy for multiple risk factors, not all of which may be present for a given child. High divorce rates
in alcoholic families makes evaluating the level of socialization risk a complex task. Quantification of that risk requires not only knowledge of the length of exposure to the actively alcoholic
parent but also the developmental period during which that exposure took place. Some developmental periods have the potential to produce greater vulnerability than others (Caspi et al. 1996). In addition,
a substantial number of alcoholic men marry alcoholic women (Schuckit et al. 2002). In such cases, risk exposure is multiplied and includes, in addition to genetic risk, increased socialization risk
associated with each parent and with the risk created by impaired marital interactions (Fuller et al. 2003). Indirect socialization effects also play a role because parental psychopathology is a risk
factor for poorer parental monitoring (Chilcoat and Anthony 1996), which, in turn, increases the probability of the COA’s involvement with a deviant peer group, including earlier exposure to alcohol- and
other drug-using peers. The offspring of alcoholics have an increased risk for psychiatric comorbidities as well as for the development of an alcohol use disorder. Hence, COA status is a
marker of increased risk for a variety of behavioral and cognitive problems. These include attention deficit disorder, behavioral undercontrol/conduct disorder, delinquency, lower IQ, poor school performance, low self-esteem, and others
(West and Prinz 1987). Research strongly suggests that some of these non–alcohol-specific characteristics lead to both problem alcohol use and elevated risk for alcohol use disorders (Caspi et al. 2002;
Donovan and Jessor 1985). For example, one community study of high-risk families (Wong et al. 2004) found that parental alcoholism was a significant predictor of early-onset alcohol use and drunkenness
(both by age 14). Fetal Alcohol Exposure. Prenatal exposure to alcohol is a potential risk factor for early-onset drinking and for later alcohol problems. Research shows that even relatively modest
levels of alcohol intake can have negative effects on the developing fetus. The effects of alcohol exposure on fetal development are referred to as teratogenic effects. Unfortunately, it is not
yet clear what, if any, level of alcohol intake is safe during pregnancy, but it is known that teratogenic risks can occur at levels of alcohol intake during pregnancy that
are not symptomatic of maternal alcoholism. Depending on the level and timing of alcohol exposure and other factors, such as nutrition and genetic vulnerability, these effects can be growth related,
neurological, structural, and behavioral, and can reflect a spectrum of alcohol-related neurodevelopmental disorders called fetal alcohol spectrum disorders (FASD). The developmental effects of prenatal alcohol exposure have been extensively studied
in both humans and animals (Brown et al. 1991; Donovan and Jessor 1985; Goldschmidt et al. 2004; Jacobson and Jacobson 2002; Mattson and Riley 1998; Olson et al. 1992; Rasmussen
2005; Streissguth et al. 1995). They include effects on response inhibition, attention, executive functioning, behavior, and school achievement, all of which are risk factors for later alcohol problems. In a
1989–1990 study involving children from 464 families in which the mothers’ drinking during pregnancy reflected a spectrum of consumption levels, the researchers followed up with the children when they were
age 14. The mothers’ alcohol intake during pregnancy significantly predicted negative consequences of alcohol use in adolescence defined as personal and social difficulties such as fighting and neglecting responsibilities. These
findings held even when controlling for family history of alcoholism, current parental drinking, and several parenting variables. When prenatal alcohol exposure was controlled for statistically, a family history of alcoholism
was not a significant predictor. A later followup of this sample found that prenatal exposure to alcohol and a family history of alcoholism predicted young adult (ages 21–24) scores on
the Alcohol Dependence Scale (Baer et al. 2003). DEVELOPMENTAL UNFOLDING OF RISK AND RESILIENCE Developmental pathways lead toward underage drinking and related problems of adolescence (risk), as well as away
from them (resilience). Substantial evidence indicates that developmental patterns evident well before 10 years of age can be used to predict both later alcohol use and alcohol problems, suggesting that
some children already have started down developmental paths leading toward early use and abuse of alcohol (Chilcoat and Anthony 1996; Donovan 2007; Zucker 2006). In some cases, high-risk pathways are
so well-established that preventive interventions should be undertaken (Biglan et al. 2004). Even so, all “predictions” about the future alcohol involvement of children and adolescents more closely resemble probabilities. The
actual pathway a given child or adolescent will take toward or away from problematic alcohol use is not certain. Many factors can intervene to change the pathway. In fact, there
are children who appear to be on the same pathways who diverge in their decision to drink. Likewise, there are those on a developmental pathway away from problematic alcohol use
who ultimately become involved in it. To better address underage drinking, it is important to understand the pathways that lead toward it as well as those that lead away from