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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of ARHGEF11 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
ARHGEF11
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: ARHGEF11 (Rho guanine nucleotide exchange factor 11)
Type: protein-coding
Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Rho protein signal transduction, actin cytoskeleton organization, establishment of cell polarity, positive regulation of DNA-templated transcription, regulation of cell growth, regulation of small GTPase mediated signal transduction, striated muscle contraction; MF: G protein-coupled receptor binding, GTPase activator activity, guanyl-nucleotide exchange factor activity, protein binding; CC: cytoplasm, cytosol, membrane, nucleoplasm, plasma membrane
Pathways: Human cytomegalovirus infection - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Regulation of RhoA activity, Signaling events mediated by focal adhesion kinase, Vascular smooth muscle contraction - Homo sapiens (human)
UniProt: O15085
Entrez ID: 9826
|
Does Knockout of BIN1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
BIN1
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: BIN1 (bridging integrator 1)
Type: protein-coding
Summary: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: T-tubule organization, cell differentiation, cytoskeleton organization, endocytosis, endosome to lysosome transport, establishment of localization in cell, lipid tube assembly, negative regulation of amyloid-beta formation, negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, negative regulation of potassium ion transmembrane transport, negative regulation of transcription by RNA polymerase II, negative regulation of ventricular cardiac muscle cell action potential, nucleus organization, positive regulation of actin filament polymerization, positive regulation of apoptotic process, positive regulation of astrocyte differentiation, positive regulation of endocytosis, regulation of cell cycle process, regulation of endocytosis, regulation of heart rate by cardiac conduction, regulation of neuron differentiation, synaptic vesicle endocytosis; MF: GTPase binding, RNA polymerase binding, actin filament binding, aspartic-type endopeptidase inhibitor activity, clathrin binding, identical protein binding, lipid binding, phospholipid binding, protease binding, protein binding, protein-containing complex binding, protein-folding chaperone binding, tau protein binding; CC: I band, RNA polymerase II transcription repressor complex, T-tubule, Z disc, actin cytoskeleton, axon, axon initial segment, axon terminus, cerebellar mossy fiber, cytoplasm, cytoskeleton, cytosol, dendrite, endosome, extrinsic component of synaptic vesicle membrane, glutamatergic synapse, lipid tube, membrane, node of Ranvier, nucleus, plasma membrane, synaptic vesicle, varicosity, vesicle
Pathways: Arf6 trafficking events, Endocytosis - Homo sapiens (human), Fc gamma R-mediated phagocytosis - Homo sapiens (human), IL-18 signaling pathway, VEGFA-VEGFR2 Signaling Pathway, endocytotic role of ndk phosphins and dynamin, p73 transcription factor network
UniProt: O00499
Entrez ID: 274
|
Does Knockout of CORO6 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
CORO6
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: CORO6 (coronin 6)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin filament organization, cell migration, negative regulation of cellular component organization; MF: actin filament binding, protein binding
Pathways:
UniProt: Q6QEF8
Entrez ID: 84940
|
Does Knockout of CLEC2A in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
CLEC2A
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CLEC2A (C-type lectin domain family 2 member A)
Type: protein-coding
Summary: CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]
Gene Ontology: MF: carbohydrate binding, identical protein binding, protein binding, protein homodimerization activity; CC: external side of plasma membrane, membrane, plasma membrane
Pathways:
UniProt: Q6UVW9
Entrez ID: 387836
|
Does Knockout of RAB11FIP1 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
RAB11FIP1
|
cell proliferation
|
T-lymphoma cell line
|
Gene: RAB11FIP1 (RAB11 family interacting protein 1)
Type: protein-coding
Summary: This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013].
Gene Ontology: BP: negative regulation of adiponectin secretion, protein transport, regulated exocytosis; MF: protein binding, small GTPase binding; CC: cytoplasm, cytoplasmic vesicle, cytosol, endosome, intracellular membrane-bounded organelle, membrane, phagocytic vesicle membrane, recycling endosome
Pathways: Endocytosis - Homo sapiens (human)
UniProt: Q6WKZ4
Entrez ID: 80223
|
Does Knockout of SON in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
SON
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: SON (SON DNA and RNA binding protein)
Type: protein-coding
Summary: This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: RNA splicing, mRNA processing, microtubule cytoskeleton organization, mitotic cytokinesis, negative regulation of apoptotic process, regulation of RNA splicing, regulation of cell cycle, regulation of mRNA splicing, via spliceosome; MF: DNA binding, RNA binding, nucleic acid binding, protein binding; CC: nuclear speck, nucleus
Pathways:
UniProt: P18583
Entrez ID: 6651
|
Does Activation of MAF in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
MAF
|
response to virus
|
Hepatoma Cell Line
|
Gene: MAF (MAF bZIP transcription factor)
Type: protein-coding
Summary: The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
Gene Ontology: BP: cell development, gene expression, in utero embryonic development, inner ear development, integrated stress response signaling, lens development in camera-type eye, lens fiber cell differentiation, megakaryocyte differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of chondrocyte differentiation, regulation of transcription by RNA polymerase II, response to nutrient, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: RNA polymerase II transcription regulator complex, chromatin, cytoplasm, nucleus
Pathways: AP-1 transcription factor network, C-MYB transcription factor network, CAMKK2 Pathway, Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Gene expression (Transcription), Generic Transcription Pathway, Inflammatory bowel disease - Homo sapiens (human), NRF2-ARE regulation, Phytochemical activity on NRF2 transcriptional activation, RNA Polymerase II Transcription, RUNX2 regulates bone development, RUNX2 regulates osteoblast differentiation, TYROBP causal network in microglia, Th1 and Th2 cell differentiation - Homo sapiens (human), Transcriptional misregulation in cancer - Homo sapiens (human), Transcriptional regulation by RUNX2, gata3 participate in activating the th2 cytokine genes expression
UniProt: O75444
Entrez ID: 4094
|
Does Knockout of BRD4 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
BRD4
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: BRD4 (bromodomain containing 4)
Type: protein-coding
Summary: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, chromatin organization, chromatin remodeling, host-mediated suppression of viral transcription, negative regulation of DNA damage checkpoint, positive regulation of DNA-templated transcription, positive regulation of G2/M transition of mitotic cell cycle, positive regulation of T-helper 17 cell lineage commitment, positive regulation of canonical NF-kappaB signal transduction, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of DNA-templated transcription, regulation of inflammatory response, regulation of transcription by RNA polymerase II; MF: P-TEFb complex binding, RNA polymerase II C-terminal domain binding, RNA polymerase II CTD heptapeptide repeat kinase activity, chromatin binding, enzyme binding, histone H3K27ac reader activity, histone H3K9ac reader activity, histone H4 reader activity, histone H4K12ac reader activity, histone H4K16ac reader activity, histone H4K5ac reader activity, histone H4K8ac reader activity, histone binding, p53 binding, protein binding, protein serine/threonine kinase activity, protein-macromolecule adaptor activity, transcription cis-regulatory region binding, transcription coactivator activity, transcription coregulator activity; CC: chromatin, chromosome, condensed nuclear chromosome, nucleoplasm, nucleus
Pathways: VEGFA-VEGFR2 Signaling Pathway
UniProt: O60885
Entrez ID: 23476
|
Does Knockout of SLC8A2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
SLC8A2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SLC8A2 (solute carrier family 8 member A2)
Type: protein-coding
Summary: Predicted to enable calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Predicted to be involved in several processes, including inorganic cation transmembrane transport; learning or memory; and regulation of short-term neuronal synaptic plasticity. Predicted to act upstream of or within several processes, including modulation of chemical synaptic transmission; regulation of action potential firing pattern; and response to ischemia. Part of presynapse. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: calcium ion export across plasma membrane, calcium ion import across plasma membrane, calcium ion transmembrane transport, calcium ion transport, cell communication, cognition, intracellular calcium ion homeostasis, learning, learning or memory, long-term synaptic potentiation, memory, modulation of excitatory postsynaptic potential, monoatomic ion transport, neuron cellular homeostasis, positive regulation of intracellular signal transduction, regulation of action potential firing pattern, regulation of calcineurin-mediated signaling, regulation of cardiac conduction, regulation of cytosolic calcium ion concentration, regulation of gene expression, regulation of postsynaptic cytosolic calcium ion concentration, regulation of short-term neuronal synaptic plasticity, response to ischemia, sodium ion transmembrane transport, sodium ion transport, synapse organization, transmembrane transport, transport across blood-brain barrier; MF: antiporter activity, calcium ion transmembrane transporter activity, calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration, calcium:sodium antiporter activity, calmodulin binding, metal ion binding, sodium ion transmembrane transporter activity; CC: axon, axon terminus, basolateral plasma membrane, cell projection, dendrite, dendritic spine, membrane, neuronal cell body, perikaryon, plasma membrane, postsynapse, postsynaptic density, presynapse, sarcolemma, synapse
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Apelin signaling pathway - Homo sapiens (human), Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Calcium signaling pathway - Homo sapiens (human), Cardiac conduction, Cardiac muscle contraction - Homo sapiens (human), Dilated cardiomyopathy - Homo sapiens (human), Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Hemostasis, Hypertrophic cardiomyopathy - Homo sapiens (human), Ion homeostasis, Metal ion SLC transporters, Mineral absorption - Homo sapiens (human), Muscle contraction, Olfactory transduction - Homo sapiens (human), Platelet calcium homeostasis, Platelet homeostasis, Protein digestion and absorption - Homo sapiens (human), Reduction of cytosolic Ca++ levels, SLC-mediated transmembrane transport, Sodium/Calcium exchangers, Transport of small molecules, cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: Q9UPR5
Entrez ID: 6543
|
Does Knockout of MCCD1 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
MCCD1
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: MCCD1 (mitochondrial coiled-coil domain 1)
Type: protein-coding
Summary: Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: P59942
Entrez ID: 401250
|
Does Knockout of PPA1 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
PPA1
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: PPA1 (inorganic pyrophosphatase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies of a similar protein in bovine suggested a cytoplasmic localization of this enzyme. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: phosphate-containing compound metabolic process; MF: hydrolase activity, inorganic diphosphate phosphatase activity, magnesium ion binding, metal ion binding, pyrophosphatase activity; CC: cytoplasm, cytosol, extracellular exosome
Pathways: Cytosolic tRNA aminoacylation, Metabolism, Metabolism of proteins, Oxidative phosphorylation - Homo sapiens (human), Pyrophosphate hydrolysis, Translation, tRNA Aminoacylation
UniProt: Q15181
Entrez ID: 5464
|
Does Knockout of SAMD4B in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
SAMD4B
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: SAMD4B (sterile alpha motif domain containing 4B)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cerebellar neuron development. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of translation, nuclear-transcribed mRNA poly(A) tail shortening, regulation of mRNA stability; MF: RNA binding, mRNA binding, protein binding, translation repressor activity; CC: P-body, cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q5PRF9
Entrez ID: 55095
|
Does Knockout of IL6ST in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
IL6ST
|
response to virus
|
Hepatoma Cell Line
|
Gene: IL6ST (interleukin 6 cytokine family signal transducer)
Type: protein-coding
Summary: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014].
Gene Ontology: BP: T-helper 17 cell lineage commitment, cell differentiation, cell surface receptor signaling pathway via JAK-STAT, cell surface receptor signaling pathway via STAT, ciliary neurotrophic factor-mediated signaling pathway, cytokine-mediated signaling pathway, glycogen metabolic process, interleukin-11-mediated signaling pathway, interleukin-27-mediated signaling pathway, interleukin-6-mediated signaling pathway, intestinal epithelial cell development, leukemia inhibitory factor signaling pathway, negative regulation of apoptotic process, negative regulation of interleukin-6-mediated signaling pathway, negative regulation of neuron apoptotic process, oncostatin-M-mediated signaling pathway, positive regulation of Notch signaling pathway, positive regulation of T cell proliferation, positive regulation of acute inflammatory response, positive regulation of adaptive immune response, positive regulation of astrocyte differentiation, positive regulation of cardiac muscle hypertrophy, positive regulation of cell population proliferation, positive regulation of osteoblast differentiation, positive regulation of platelet aggregation, positive regulation of vascular endothelial growth factor production, regulation of Notch signaling pathway, response to cytokine, signal transduction; MF: ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, coreceptor activity, cytokine binding, cytokine receptor activity, growth factor binding, identical protein binding, interleukin-11 binding, interleukin-11 receptor activity, interleukin-27 receptor activity, interleukin-6 binding, interleukin-6 receptor activity, interleukin-6 receptor binding, leukemia inhibitory factor receptor activity, oncostatin-M receptor activity, protein binding, protein tyrosine kinase activator activity, scaffold protein binding; CC: cell body, ciliary neurotrophic factor receptor complex, dendrite, external side of plasma membrane, extracellular exosome, extracellular region, extracellular space, interleukin-6 receptor complex, membrane, membrane raft, neuronal cell body, oncostatin-M receptor complex, plasma membrane, receptor complex
Pathways: Adipogenesis, AndrogenReceptor, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), ESC Pluripotency Pathways, FOXP3 in COVID-19, IL-6 signaling pathway, IL11, IL27-mediated signaling events, IL6, IL6-mediated signaling events, Immune System, Interleukin-11 Signaling Pathway, Interleukin-6 family signaling, Interleukin-6 signaling, JAK-STAT signaling pathway - Homo sapiens (human), Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Mammary gland development pathway - Involution (Stage 4 of 4), MicroRNAs in cardiomyocyte hypertrophy, Oncostatin M Signaling Pathway, Oncostatin_M, Pathways in cancer - Homo sapiens (human), Physiological and pathological hypertrophy of the heart, Regulatory circuits of the STAT3 signaling pathway, SHP2 signaling, Senescence and Autophagy in Cancer, Signaling by Interleukins, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Th17 cell differentiation - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human), ncRNAs involved in STAT3 signaling in hepatocellular carcinoma
UniProt: P40189
Entrez ID: 3572
|
Does Knockout of TGS1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
TGS1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: TGS1 (trimethylguanosine synthase 1)
Type: protein-coding
Summary: Enables RNA trimethylguanosine synthase activity. Involved in 7-methylguanosine cap hypermethylation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA methylation, methylation, ribonucleoprotein complex biogenesis, spliceosomal snRNP assembly; MF: RNA cap trimethylguanosine synthase activity, RNA methyltransferase activity, methyltransferase activity, protein binding, transferase activity; CC: Cajal body, cytoplasm, cytosol, extracellular space, nucleolus, nucleoplasm, nucleus, small nuclear ribonucleoprotein complex
Pathways: Activation of gene expression by SREBF (SREBP), Adipogenesis, BMAL1:CLOCK,NPAS2 activates circadian expression, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Cytoprotection by HMOX1, Developmental Biology, Expression of BMAL (ARNTL), CLOCK, and NPAS2, Heme signaling, Metabolism, Metabolism of RNA, Metabolism of lipids, Metabolism of non-coding RNA, Metabolism of steroids, Mitochondrial biogenesis, Organelle biogenesis and maintenance, PPARA activates gene expression, RNA transport - Homo sapiens (human), RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of lipid metabolism by PPARalpha, Transcriptional activation of mitochondrial biogenesis, Transcriptional regulation of white adipocyte differentiation, snRNP Assembly
UniProt: Q96RS0
Entrez ID: 96764
|
Does Knockout of FYB1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
FYB1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: FYB1 (FYN binding protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
Gene Ontology: BP: T cell receptor signaling pathway, immune response, integrin-mediated signaling pathway, protein localization to plasma membrane; MF: lipid binding, protein binding, signaling receptor binding; CC: actin cytoskeleton, anchoring junction, cytoplasm, cytosol, nucleus, plasma membrane, protein-containing complex
Pathways: Adaptive Immune System, Cell-Cell communication, Generation of second messenger molecules, Immune System, Overview of leukocyte-intrinsic Hippo pathway functions, Rap1 signaling pathway - Homo sapiens (human), Signal regulatory protein family interactions, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling, TCR signaling in naïve CD4+ T cells, Yersinia infection - Homo sapiens (human)
UniProt: O15117
Entrez ID: 2533
|
Does Knockout of ARHGAP10 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
ARHGAP10
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: ARHGAP10 (Rho GTPase activating protein 10)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in cytoskeleton organization and negative regulation of apoptotic process. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoskeleton organization, negative regulation of apoptotic process, regulation of small GTPase mediated signal transduction, signal transduction; MF: GTPase activator activity, protein binding; CC: cytoplasm, cytosol, endosome, endosome membrane, membrane, perinuclear region of cytoplasm, plasma membrane
Pathways: Arf1 pathway, Bacterial invasion of epithelial cells - Homo sapiens (human), Ectoderm Differentiation
UniProt: A1A4S6
Entrez ID: 79658
|
Does Knockout of ACTR1A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
ACTR1A
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ACTR1A (actin related protein 1A)
Type: protein-coding
Summary: This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: ATP binding, nucleotide binding, protein binding; CC: cell cortex, centrosome, cytoplasm, cytoskeleton, cytosol, dynactin complex, extracellular exosome, microtubule associated complex, microtubule organizing center
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Amyotrophic lateral sclerosis - Homo sapiens (human), Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Homo sapiens (human), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Salmonella infection - Homo sapiens (human), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: P61163
Entrez ID: 10121
|
Does Knockout of IL5 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 787
|
Knockout
|
IL5
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: IL5 (interleukin 5)
Type: protein-coding
Summary: This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: cytokine-mediated signaling pathway, eosinophil differentiation, immune response, inflammatory response, interleukin-5-mediated signaling pathway, positive regulation of B cell proliferation, positive regulation of cell population proliferation, positive regulation of eosinophil differentiation, positive regulation of immunoglobulin production, positive regulation of podosome assembly, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of transcription by RNA polymerase II; MF: cytokine activity, growth factor activity, interleukin-5 receptor binding, protein binding; CC: extracellular region, extracellular space
Pathways: AP-1 transcription factor network, Allograft Rejection, Allograft rejection - Homo sapiens (human), Asthma - Homo sapiens (human), Autoimmune thyroid disease - Homo sapiens (human), Calcineurin-regulated NFAT-dependent transcription in lymphocytes, Control of immune tolerance by vasoactive intestinal peptide, Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Cytokines and Inflammatory Response, Development and heterogeneity of the ILC family, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Glucocorticoid receptor regulatory network, Hematopoietic cell lineage - Homo sapiens (human), IL-17 signaling pathway - Homo sapiens (human), IL4-mediated signaling events, IL5, IL5-mediated signaling events, Immune System, Inflammatory Response Pathway, Inflammatory bowel disease - Homo sapiens (human), Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intestinal immune network for IgA production - Homo sapiens (human), JAK-STAT signaling pathway - Homo sapiens (human), Lung fibrosis, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Pathways in cancer - Homo sapiens (human), RAF/MAP kinase cascade, Regulation of nuclear SMAD2/3 signaling, Selective expression of chemokine receptors during T-cell polarization, Signal Transduction, Signaling by Interleukins, T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, Th1 and Th2 cell differentiation - Homo sapiens (human), gata3 participate in activating the th2 cytokine genes expression
UniProt: P05113
Entrez ID: 3567
|
Does Knockout of TRIM49D1 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
TRIM49D1
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: TRIM49D1 (tripartite motif containing 49D1)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: innate immune response, regulation of gene expression; MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: C9J1S8
Entrez ID: 399939
|
Does Knockout of NKD1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
NKD1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: NKD1 (NKD inhibitor of Wnt signaling pathway 1)
Type: protein-coding
Summary: In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003].
Gene Ontology: BP: Wnt signaling pathway, axis elongation, convergent extension, eye photoreceptor cell differentiation, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, positive regulation of MAPK cascade, positive regulation of Wnt signaling pathway, planar cell polarity pathway, positive regulation of non-canonical Wnt signaling pathway, positive regulation of protein catabolic process, regulation of cell migration involved in somitogenic axis elongation, somatic muscle development; MF: PDZ domain binding, calcium ion binding, metal ion binding, protein binding; CC: cytoplasm, membrane, plasma membrane, protein phosphatase type 2A complex
Pathways: Hippo signaling pathway - Homo sapiens (human), LncRNA involvement in canonical Wnt signaling and colorectal cancer, Presenilin action in Notch and Wnt signaling, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages, multi-step regulation of transcription by pitx2, ncRNAs involved in Wnt signaling in hepatocellular carcinoma, segmentation clock, wnt signaling pathway
UniProt: Q969G9
Entrez ID: 85407
|
Does Knockout of B3GNT5 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
B3GNT5
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5)
Type: protein-coding
Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates and is identified as the most likely candidate for lactotriaosylceramide synthase. This enzyme is essential for the expression of Lewis X epitopes on glycolipids. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate derivative biosynthetic process, central nervous system development, glycolipid biosynthetic process, glycosphingolipid biosynthetic process, lipid metabolic process, protein O-linked glycosylation, protein O-linked glycosylation via N-acetyl-galactosamine, protein glycosylation, sphingolipid biosynthetic process; MF: N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity, glycosyltransferase activity, hexosyltransferase activity, lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity, protein binding, transferase activity; CC: Golgi apparatus, Golgi membrane, membrane
Pathways: Glucocorticoid Receptor Pathway, Glycosphingolipid biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human), Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Metabolism of proteins, Nuclear Receptors Meta-Pathway, O-linked glycosylation, O-linked glycosylation of mucins, Post-translational protein modification, Sphingolipid metabolism
UniProt: Q9BYG0
Entrez ID: 84002
|
Does Knockout of MRAP in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
MRAP
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: MRAP (melanocortin 2 receptor accessory protein)
Type: protein-coding
Summary: This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling of other melanocortin receptors. Mutations in this gene have been associated with familial glucocorticoid deficiency type 2. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009].
Gene Ontology: BP: negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, negative regulation of protein localization to plasma membrane, positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, protein localization to plasma membrane, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; MF: corticotropin hormone receptor binding, identical protein binding, protein binding, signaling receptor regulator activity, type 1 melanocortin receptor binding, type 3 melanocortin receptor binding, type 4 melanocortin receptor binding, type 5 melanocortin receptor binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Cortisol synthesis and secretion - Homo sapiens (human), Cushing syndrome - Homo sapiens (human)
UniProt: Q8TCY5
Entrez ID: 56246
|
Does Knockout of NPIPB5 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
NPIPB5
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NPIPB5 (nuclear pore complex interacting protein family member B5)
Type: protein-coding
Summary: Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: A8MRT5
Entrez ID: 100132247
|
Does Knockout of MYO10 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
MYO10
|
response to virus
|
Hepatoma Cell Line
|
Gene: MYO10 (myosin X)
Type: protein-coding
Summary: This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: cytoskeleton-dependent intracellular transport, positive regulation of cell-cell adhesion, regulation of cell shape, regulation of filopodium assembly, signal transduction; MF: ATP binding, actin binding, actin filament binding, calmodulin binding, cytoskeletal motor activity, cytoskeletal protein binding, microfilament motor activity, nucleotide binding, phosphatidylinositol-3,4,5-trisphosphate binding, plus-end directed microfilament motor activity, protein binding, protein-containing complex binding, spectrin binding; CC: cell cortex, cell projection, cytoplasm, cytoskeleton, cytosol, filopodium, filopodium membrane, filopodium tip, lamellipodium, membrane, myosin complex, neuron projection, neuronal cell body, nucleolus, plasma membrane, ruffle
Pathways: Axon guidance, Developmental Biology, Disease, FCGR3A-mediated phagocytosis, Fc gamma R-mediated phagocytosis - Homo sapiens (human), Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Infectious disease, Innate Immune System, Leishmania infection, Leishmania phagocytosis, Nervous system development, Netrin-1 signaling, Netrin-mediated signaling events, Parasite infection, Parasitic Infection Pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), Regulation of actin dynamics for phagocytic cup formation
UniProt: Q9HD67
Entrez ID: 4651
|
Does Knockout of STIL in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
STIL
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: STIL (STIL centriolar assembly protein)
Type: protein-coding
Summary: This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes to daughter cells. The protein is phosphorylated in mitosis and in response to activation of the spindle checkpoint, and disappears when cells transition to G1 phase. It interacts with a mitotic regulator, and its expression is required to efficiently activate the spindle checkpoint. It is proposed to regulate Cdc2 kinase activity during spindle checkpoint arrest. Chromosomal deletions that fuse this gene and the adjacent locus commonly occur in T cell leukemias, and are thought to arise through illegitimate V-(D)-J recombination events. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: centrosome duplication, determination of left/right symmetry, embryonic axis specification, floor plate development, forebrain development, heart looping, in utero embryonic development, microtubule organizing center organization, mitotic spindle organization, multicellular organism growth, negative regulation of apoptotic process, neural tube closure, neural tube development, notochord development, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of centriole replication, positive regulation of spindle assembly, protein localization to centrosome, regulation of centriole replication, regulation of mitotic spindle organization, smoothened signaling pathway; MF: identical protein binding, protein binding; CC: cell cortex, centriole, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, microtubule organizing center, nucleoplasm, procentriole replication complex
Pathways: Signaling events mediated by the Hedgehog family
UniProt: Q15468
Entrez ID: 6491
|
Does Knockout of GFRA2 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
GFRA2
|
response to chemicals
|
Melanoma Cell Line
|
Gene: GFRA2 (GDNF family receptor alpha 2)
Type: protein-coding
Summary: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cell surface receptor protein tyrosine kinase signaling pathway, glial cell-derived neurotrophic factor receptor signaling pathway, nervous system development; MF: glial cell-derived neurotrophic factor receptor activity, heparan sulfate binding, signaling receptor activity; CC: external side of plasma membrane, extrinsic component of membrane, membrane, plasma membrane, receptor complex, side of membrane
Pathways: Axon guidance, Developmental Biology, MAPK family signaling cascades, MAPK1/MAPK3 signaling, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, RAF/MAP kinase cascade, RET signaling, Signal Transduction
UniProt: O00451
Entrez ID: 2675
|
Does Knockout of SLC5A8 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
SLC5A8
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: SLC5A8 (solute carrier family 5 member 8)
Type: protein-coding
Summary: SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).[supplied by OMIM, Dec 2008].
Gene Ontology: BP: NAD+ biosynthetic process via the salvage pathway, acetate transport, apoptotic process, chloride transport, iodide transport, lactate transmembrane transport, lactate transport, monoatomic ion transport, monocarboxylic acid transport, nicotinate transport, nitrate transmembrane transport, propanoate transmembrane transport, pyruvate transport, short-chain fatty acid transmembrane transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: iodide channel activity, lactate transmembrane transporter activity, monocarboxylate:sodium symporter activity, monocarboxylic acid transmembrane transporter activity, organic acid:sodium symporter activity, propionate transmembrane transporter activity, protein binding, short-chain fatty acid transmembrane transporter activity, solute:sodium symporter activity, symporter activity, transmembrane transporter activity; CC: GINS complex, apical plasma membrane, extracellular exosome, membrane, plasma membrane
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, NRF2 pathway, Nicotinate metabolism, Nuclear Receptors Meta-Pathway, Organic anion transport by SLC5/17/25 transporters, Proximal tubule transport, SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: Q8N695
Entrez ID: 160728
|
Does Knockout of TUBA3E in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
TUBA3E
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: TUBA3E (tubulin alpha 3e)
Type: protein-coding
Summary: Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. This gene encodes an alpha tubulin that highly conserved among species. A missense mutation in this gene has been potentially linked to microlissencephaly and global developmental delay. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, hydrolase activity, metal ion binding, nucleotide binding, protein binding, structural constituent of cytoskeleton; CC: cilium, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, nucleus
Pathways: Activation of AMPK downstream of NMDARs, Activation of NMDA receptors and postsynaptic events, Adaptive Immune System, Aggrephagy, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Homo sapiens (human), Asparagine N-linked glycosylation, Assembly and cell surface presentation of NMDA receptors, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Chaperonin-mediated protein folding, Cilium Assembly, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Cytokine Signaling in Immune system, Developmental Biology, Disease, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, Formation of tubulin folding intermediates by CCT/TriC, G2/M Transition, Gap junction - Homo sapiens (human), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HCMV Early Events, HCMV Infection, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hemostasis, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phagosome - Homo sapiens (human), Post NMDA receptor activation events, Post-chaperonin tubulin folding pathway, Post-translational protein modification, Prion disease - Homo sapiens (human), Protein folding, RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Homo sapiens (human), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, Transmission across Chemical Synapses, Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, Viral Infection Pathways
UniProt: Q6PEY2
Entrez ID: 112714
|
Does Knockout of KDM6B in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
KDM6B
|
cell proliferation
|
Cancer Cell Line
|
Gene: KDM6B (lysine demethylase 6B)
Type: protein-coding
Summary: The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017].
Gene Ontology: BP: cardiac muscle cell differentiation, cell fate commitment, cellular response to hydrogen peroxide, chromatin organization, chromatin remodeling, endothelial cell differentiation, heart development, hippocampus development, inflammatory response, inflammatory response to antigenic stimulus, mesodermal cell differentiation, positive regulation of cold-induced thermogenesis, positive regulation of transcription by RNA polymerase II, regulation of gene expression, response to activity, response to fungicide; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, beta-catenin binding, chromatin DNA binding, chromatin binding, dioxygenase activity, histone H3K27me2/H3K27me3 demethylase activity, histone demethylase activity, metal ion binding, oxidoreductase activity, protein binding, sequence-specific DNA binding; CC: MLL3/4 complex, nucleoplasm, nucleus
Pathways: Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifications during the maternal to zygotic transition (MZT), Chromatin modifying enzymes, Chromatin organization, Developmental Biology, HDMs demethylate histones, Maternal to zygotic transition (MZT), Oxidative Stress Induced Senescence, Pathways affected in adenoid cystic carcinoma, Vitamin D-sensitive calcium signaling in depression
UniProt: O15054
Entrez ID: 23135
|
Does Knockout of DHRS11 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
DHRS11
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: DHRS11 (dehydrogenase/reductase 11)
Type: protein-coding
Summary: Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; and 3-keto sterol reductase activity. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: estrogen biosynthetic process, lipid metabolic process, steroid biosynthetic process, steroid metabolic process; MF: 17-beta-hydroxysteroid dehydrogenase (NADP+) activity, 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, nucleotide binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding
Pathways: Steroid hormone biosynthesis - Homo sapiens (human)
UniProt: Q6UWP2
Entrez ID: 79154
|
Does Knockout of SYT11 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
SYT11
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: SYT11 (synaptotagmin 11)
Type: protein-coding
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010].
Gene Ontology: BP: autophagy, calcium ion regulated lysosome exocytosis, calcium-dependent activation of synaptic vesicle fusion, establishment of vesicle localization, learning, memory, negative regulation of cytokine production, negative regulation of dopamine secretion, negative regulation of endocytosis, negative regulation of interleukin-6 production, negative regulation of microglial cell activation, negative regulation of neurotransmitter secretion, negative regulation of phagocytosis, negative regulation of secretion by cell, negative regulation of tumor necrosis factor production, plasma membrane repair, positive regulation of protein localization to phagocytic vesicle, regulation of calcium ion-dependent exocytosis, regulation of defense response to bacterium, regulation of phagosome maturation, regulation of synaptic vesicle endocytosis, response to wounding, vesicle fusion, vesicle-mediated transport; MF: SNARE binding, beta-tubulin binding, calcium ion binding, calcium ion sensor activity, calcium-dependent phospholipid binding, identical protein binding, metal ion binding, protein binding, translation initiation factor binding, ubiquitin protein ligase binding; CC: Golgi apparatus, axon, cell projection, clathrin-coated vesicle membrane, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, dendrite, dendritic spine, dopaminergic synapse, early phagosome, endosome, excitatory synapse, exocytic vesicle, inhibitory synapse, lysosomal membrane, lysosome, membrane, neuron projection, perikaryon, phagocytic cup, phagocytic vesicle, plasma membrane, postsynaptic density, presynapse, presynaptic active zone membrane, recycling endosome, recycling endosome membrane, synapse, synaptic vesicle, trans-Golgi network, vesicle
Pathways: Cargo recognition for clathrin-mediated endocytosis, Clathrin-mediated endocytosis, Membrane Trafficking, Parkinson,s disease pathway, Vesicle-mediated transport
UniProt: Q9BT88
Entrez ID: 23208
|
Does Knockout of SENP5 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
SENP5
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: SENP5 (SUMO specific peptidase 5)
Type: protein-coding
Summary: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009].
Gene Ontology: BP: cell division, protein desumoylation, protein sumoylation, proteolysis; MF: SUMO-specific endopeptidase activity, cysteine-type peptidase activity, deSUMOylase activity, hydrolase activity, peptidase activity, protein binding; CC: nucleolus, nucleoplasm, nucleus, postsynaptic cytosol, presynaptic cytosol
Pathways: 3q29 copy number variation syndrome, Metabolism of proteins, Post-translational protein modification, Processing and activation of SUMO, SUMO is proteolytically processed, SUMOylation
UniProt: Q96HI0
Entrez ID: 205564
|
Does Knockout of SNU13 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
SNU13
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: SNU13 (small nuclear ribonucleoprotein 13)
Type: protein-coding
Summary: Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, box C/D snoRNP assembly, mRNA processing, mRNA splicing, via spliceosome, maturation of SSU-rRNA, ribosomal small subunit biogenesis, ribosome biogenesis, single fertilization; MF: ATPase binding, RNA binding, U3 snoRNA binding, U4 snRNA binding, U4atac snRNA binding, box C/D sno(s)RNA binding, protein binding, snoRNA binding; CC: U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U4atac snRNP, box C/D methylation guide snoRNP complex, dense fibrillar component, nucleolus, nucleoplasm, nucleus, precatalytic spliceosome, protein-containing complex, ribonucleoprotein complex, small-subunit processome, spliceosomal complex
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P55769
Entrez ID: 4809
|
Does Knockout of ATF7 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
ATF7
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: ATF7 (activating transcription factor 7)
Type: protein-coding
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, cAMP response element binding, enzyme binding, metal ion binding, mitogen-activated protein kinase binding, protein binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coactivator binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, chromatin, chromosome, chromosome, telomeric region, cytoplasm, nucleoplasm, nucleus
Pathways: Regulation of retinoblastoma protein
UniProt: P17544
Entrez ID: 11016
|
Does Knockout of MTFMT in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
MTFMT
|
cell proliferation
|
T-lymphoma cell line
|
Gene: MTFMT (mitochondrial methionyl-tRNA formyltransferase)
Type: protein-coding
Summary: The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA, translation, translational initiation; MF: catalytic activity, methionyl-tRNA formyltransferase activity, transferase activity; CC: mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Cystathionine Beta-Synthase Deficiency, Folate Metabolism, Folate malabsorption, hereditary, Glycine N-methyltransferase Deficiency, Homocystinuria-megaloblastic anemia due to defect in cobalamin metabolism, cblG complementation type, Hypermethioninemia, Metabolism of proteins, Methionine Adenosyltransferase Deficiency, Methionine Metabolism, Methotrexate Action Pathway, Methylenetetrahydrofolate Reductase Deficiency (MTHFRD), Mitochondrial translation, Mitochondrial translation initiation, One carbon pool by folate - Homo sapiens (human), One-carbon metabolism, S-Adenosylhomocysteine (SAH) Hydrolase Deficiency, Translation
UniProt: Q96DP5
Entrez ID: 123263
|
Does Knockout of ERGIC3 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
ERGIC3
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: ERGIC3 (ERGIC and golgi 3)
Type: protein-coding
Summary: Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, positive regulation of intracellular protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; CC: COPII-coated ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, retrograde transporter complex, Golgi to ER, transporter complex
Pathways:
UniProt: Q9Y282
Entrez ID: 51614
|
Does Knockout of CDK2AP1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
CDK2AP1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CDK2AP1 (cyclin dependent kinase 2 associated protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: DNA-templated DNA replication, positive regulation of protein phosphorylation, regulation of transcription by RNA polymerase II; MF: DNA polymerase binding, protein binding; CC: NuRD complex, chromatin, chromosome, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: O14519
Entrez ID: 8099
|
Does Knockout of NDC80 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
NDC80
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: NDC80 (NDC80 kinetochore complex component)
Type: protein-coding
Summary: This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011].
Gene Ontology: BP: G2/MI transition of meiotic cell cycle, attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, centrosome duplication, chromosome organization, chromosome segregation, establishment of mitotic spindle orientation, kinetochore organization, metaphase chromosome alignment, mitotic cell cycle, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization, nuclear chromosome segregation, nuclear division, positive regulation of mitotic cell cycle spindle assembly checkpoint, regulation of protein stability, skeletal muscle satellite cell proliferation, spindle assembly involved in female meiosis I, spindle organization; MF: cyclin binding, identical protein binding, kinetochore adaptor activity, microtubule binding, protein binding; CC: Ndc80 complex, centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytosol, kinetochore, membrane, nuclear speck, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Aurora B signaling, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, PLK1 signaling events, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O14777
Entrez ID: 10403
|
Does Knockout of ADAR in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
ADAR
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: ADAR (adenosine deaminase RNA specific)
Type: protein-coding
Summary: This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010].
Gene Ontology: BP: RISC complex assembly, RNA processing, adenosine to inosine editing, apoptotic process, base conversion or substitution editing, cellular response to virus, defense response to virus, definitive hemopoiesis, erythrocyte differentiation, hematopoietic progenitor cell differentiation, hematopoietic stem cell homeostasis, hepatocyte apoptotic process, immune system process, innate immune response, mRNA processing, miRNA processing, negative regulation of hepatocyte apoptotic process, negative regulation of post-transcriptional gene silencing by regulatory ncRNA, negative regulation of protein kinase activity by regulation of protein phosphorylation, negative regulation of type I interferon-mediated signaling pathway, osteoblast differentiation, positive regulation of viral genome replication, pre-miRNA processing, protein export from nucleus, protein import into nucleus, regulatory ncRNA-mediated gene silencing, response to interferon-alpha, response to virus, somatic diversification of immune receptors via somatic mutation; MF: DNA binding, RNA binding, adenosine deaminase activity, double-stranded RNA adenosine deaminase activity, double-stranded RNA binding, hydrolase activity, metal ion binding, protein binding, tRNA-specific adenosine deaminase activity; CC: cytoplasm, cytosol, membrane, mitochondrion, nuclear lumen, nucleolus, nucleoplasm, nucleus, supraspliceosomal complex
Pathways: Coronavirus disease - COVID-19 - Homo sapiens (human), Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Influenza A - Homo sapiens (human), Measles - Homo sapiens (human), antisense pathway
UniProt: P55265
Entrez ID: 103
|
Does Knockout of NOL8 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
NOL8
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: NOL8 (nucleolar protein 8)
Type: protein-coding
Summary: NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: protein localization to nucleolus, rRNA processing; MF: RNA binding, nucleic acid binding, protein binding; CC: chromosome, nucleolus, nucleus
Pathways:
UniProt: Q76FK4
Entrez ID: 55035
|
Does Knockout of DPYSL5 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
DPYSL5
|
cell proliferation
|
Cancer Cell Line
|
Gene: DPYSL5 (dihydropyrimidinase like 5)
Type: protein-coding
Summary: This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: axon guidance, negative regulation of dendrite morphogenesis, nervous system development, neuron differentiation, pyrimidine nucleobase catabolic process, signal transduction; MF: dihydropyrimidinase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides, protein binding; CC: cytoplasm, cytosol, dendrite, glutamatergic synapse, neuronal cell body, protein-containing complex, synapse
Pathways: Axon guidance, Axon guidance - Homo sapiens (human), CRMPs in Sema3A signaling, Developmental Biology, Nervous system development, Semaphorin interactions
UniProt: Q9BPU6
Entrez ID: 56896
|
Does Knockout of ZMAT2 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
ZMAT2
|
response to virus
|
Hepatoma Cell Line
|
Gene: ZMAT2 (zinc finger matrin-type 2)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and zinc ion binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: DNA binding, metal ion binding, nucleic acid binding, protein binding, zinc ion binding; CC: U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q96NC0
Entrez ID: 153527
|
Does Knockout of ETNK2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
ETNK2
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: ETNK2 (ethanolamine kinase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
Gene Ontology: BP: in utero embryonic development, lipid metabolic process, multicellular organism growth, phosphatidylethanolamine biosynthetic process, phospholipid biosynthetic process, placenta development, post-embryonic development; MF: ATP binding, ethanolamine kinase activity, kinase activity, nucleotide binding, protein binding, transferase activity; CC: cytoplasm, cytosol
Pathways: Glucocorticoid Receptor Pathway, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Kennedy pathway from sphingolipids, Metabolism, Metabolism of lipids, Nuclear Receptors Meta-Pathway, One-carbon metabolism and related pathways, Phospholipid metabolism, Synthesis of PE, phosphatidylethanolamine biosynthesis II
UniProt: Q9NVF9
Entrez ID: 55224
|
Does Knockout of USP17L25 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
USP17L25
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: USP17L25 (ubiquitin specific peptidase 17 like family member 25)
Type: protein-coding
Summary: Enables RNA binding activity; hyaluronic acid binding activity; and thiol-dependent deubiquitinase. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q0WX57
Entrez ID: 728373
|
Does Knockout of PSMA1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,996
|
Knockout
|
PSMA1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: PSMA1 (proteasome 20S subunit alpha 1)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009].
Gene Ontology: BP: immune system process, negative regulation of inflammatory response to antigenic stimulus, proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: lipopolysaccharide binding, protein binding; CC: centrosome, cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), proteasome complex
UniProt: P25786
Entrez ID: 5682
|
Does Knockout of GPR157 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
GPR157
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: GPR157 (G protein-coupled receptor 157)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway and radial glial cell differentiation. Predicted to be located in ciliary membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cell differentiation, cell surface receptor signaling pathway, circadian behavior, phospholipase C-activating G protein-coupled receptor signaling pathway, radial glial cell differentiation, signal transduction; MF: G protein-coupled receptor activity, transmembrane signaling receptor activity; CC: cell projection, ciliary membrane, membrane, plasma membrane
Pathways:
UniProt: Q5UAW9
Entrez ID: 80045
|
Does Knockout of MSMP in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
MSMP
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: MSMP (microseminoprotein, prostate associated)
Type: protein-coding
Summary: This gene encodes a member of the beta-microseminoprotein family. Members of this protein family contain ten conserved cysteine residues that form intra-molecular disulfide bonds. The encoded protein may play a role in prostate cancer tumorigenesis. [provided by RefSeq, Jan 2011].
Gene Ontology: BP: chemotaxis, inflammatory response, lymphocyte chemotaxis, monocyte chemotaxis, signal transduction; MF: CCR2 chemokine receptor binding, cytokine activity; CC: cytoplasm, extracellular region, extracellular space
Pathways: Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors
UniProt: Q1L6U9
Entrez ID: 692094
|
Does Knockout of PFN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
PFN1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PFN1 (profilin 1)
Type: protein-coding
Summary: This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: actin cytoskeleton organization, modification of postsynaptic actin cytoskeleton, modulation of chemical synaptic transmission, negative regulation of actin filament bundle assembly, negative regulation of stress fiber assembly, neural tube closure, positive regulation of actin filament bundle assembly, positive regulation of actin filament polymerization, positive regulation of epithelial cell migration, positive regulation of ruffle assembly, protein stabilization, regulation of actin filament organization, regulation of actin filament polymerization, regulation of transcription by RNA polymerase II, synapse maturation; MF: RNA binding, actin binding, actin monomer binding, adenyl-nucleotide exchange factor activity, cadherin binding, phosphatidylinositol-4,5-bisphosphate binding, phosphotyrosine residue binding, proline-rich region binding, protein binding, small GTPase binding; CC: blood microparticle, cell cortex, cytoplasm, cytoskeleton, cytosol, extracellular exosome, focal adhesion, glutamatergic synapse, membrane, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Association Between Physico-Chemical Features and Toxicity Associated Pathways, Axon guidance, Beta-catenin independent WNT signaling, Developmental Biology, EGFR1, G13 Signaling Pathway, Hemostasis, Nervous system development, PCP/CE pathway, Platelet activation, signaling and aggregation, Platelet degranulation , RHO GTPase Effectors, RHO GTPases Activate Formins, Rap1 signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), Response to elevated platelet cytosolic Ca2+, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by ROBO receptors, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by WNT, VEGFA-VEGFR2 Signaling Pathway, erk and pi-3 kinase are necessary for collagen binding in corneal epithelia, rho cell motility signaling pathway
UniProt: P07737
Entrez ID: 5216
|
Does Knockout of RPL26 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
RPL26
|
cell proliferation
|
Bladder Carcinoma
|
Gene: RPL26 (ribosomal protein L26)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, cellular response to UV, cellular response to gamma radiation, cytoplasmic translation, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, positive regulation of translation, rRNA processing, regulation of translation involved in cellular response to UV, ribosomal large subunit biogenesis, translation; MF: RNA binding, mRNA 5'-UTR binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, extracellular exosome, large ribosomal subunit, membrane, nucleolus, nucleoplasm, ribonucleoprotein complex, ribosome
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, VEGFA-VEGFR2 Signaling Pathway, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P61254
Entrez ID: 6154
|
Does Knockout of WARS2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
WARS2
|
cell proliferation
|
Cancer Cell Line
|
Gene: WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial tryptophanyl-tRNA aminoacylation, positive regulation of angiogenesis, tRNA aminoacylation for protein translation, translation, tryptophanyl-tRNA aminoacylation, vasculogenesis; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, tryptophan-tRNA ligase activity; CC: mitochondrial matrix, mitochondrion, nucleoplasm, plasma membrane
Pathways: Aminoacyl-tRNA biosynthesis - Homo sapiens (human), Metabolism of proteins, Mitochondrial tRNA aminoacylation, Translation, Tryptophan Metabolism, tRNA Aminoacylation, tRNA charging
UniProt: Q9UGM6
Entrez ID: 10352
|
Does Knockout of RPF1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
RPF1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RPF1 (ribosome production factor 1 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing, ribosome biogenesis; MF: RNA binding, protein binding, rRNA binding, rRNA primary transcript binding; CC: nucleolus, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q9H9Y2
Entrez ID: 80135
|
Does Knockout of KLHL12 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
KLHL12
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: KLHL12 (kelch like family member 12)
Type: protein-coding
Summary: This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: COPII vesicle coating, Wnt signaling pathway, anatomical structure morphogenesis, endoplasmic reticulum to Golgi vesicle-mediated transport, neural crest cell development, neural crest formation, proteasome-mediated ubiquitin-dependent protein catabolic process, protein monoubiquitination, protein ubiquitination, tissue development, vesicle-mediated transport; MF: identical protein binding, protein binding, ubiquitin-like ligase-substrate adaptor activity; CC: COPII vesicle coat, COPII-coated ER to Golgi transport vesicle, Cul3-RING ubiquitin ligase complex, centriolar satellite, cytoplasm, cytoplasmic vesicle, cytosol
Pathways: Canonical Wnt signaling pathway, Degradation of DVL, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q53G59
Entrez ID: 59349
|
Does Knockout of SBSPON in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
SBSPON
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SBSPON (somatomedin B and thrombospondin type 1 domain containing)
Type: protein-coding
Summary: Predicted to be an extracellular matrix structural constituent. Colocalizes with collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: extracellular matrix, extracellular region
Pathways: Defective B3GALTL causes PpS, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification
UniProt: Q8IVN8
Entrez ID: 157869
|
Does Knockout of ZBTB8OS in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
ZBTB8OS
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: ZBTB8OS (zinc finger and BTB domain containing 8 opposite strand)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: tRNA processing, tRNA splicing, via endonucleolytic cleavage and ligation; MF: metal ion binding, protein binding; CC: cytoplasm, nucleoplasm, nucleus, tRNA-splicing ligase complex
Pathways:
UniProt: Q8IWT0
Entrez ID: 339487
|
Does Knockout of QSER1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
QSER1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: QSER1 (glutamine and serine rich 1)
Type: protein-coding
Summary: Predicted to be located in chromosome. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q2KHR3
Entrez ID: 79832
|
Does Knockout of EIF2B3 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
EIF2B3
|
cell proliferation
|
Cancer Cell Line
|
Gene: EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)
Type: protein-coding
Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: T cell receptor signaling pathway, central nervous system development, cytoplasmic translational initiation, oligodendrocyte development, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, protein binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Homo sapiens (human), Metabolism of proteins, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Translation, Translation Factors
UniProt: Q9NR50
Entrez ID: 8891
|
Does Knockout of RPS9 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
RPS9
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: RPS9 (ribosomal protein S9)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S4P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, multiple processed pseudogenes derived from this gene are dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, ribosomal small subunit biogenesis, translation; MF: RNA binding, protein binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, extracellular exosome, focal adhesion, membrane, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P46781
Entrez ID: 6203
|
Does Knockout of MFAP1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
MFAP1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: MFAP1 (microfibril associated protein 1)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in centrosome; microfibril; and nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2-type precatalytic spliceosome, U2-type spliceosomal complex, centrosome, microfibril, nucleoplasm, nucleus, spliceosomal complex
Pathways: Canonical and non-canonical Notch signaling, Ciliary landscape, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P55081
Entrez ID: 4236
|
Does Knockout of ICOSLG in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
ICOSLG
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: ICOSLG (inducible T cell costimulator ligand)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-4 production. Located in cytoplasmic ribonucleoprotein granule and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: B cell activation, T cell activation, T cell receptor signaling pathway, T follicular helper cell differentiation, adaptive immune response, defense response, hyperosmotic response, immune system process, positive regulation of activated T cell proliferation, regulation of cytokine production, signal transduction; MF: identical protein binding, protein binding, receptor ligand activity, signaling receptor binding; CC: external side of plasma membrane, extracellular exosome, membrane, plasma membrane
Pathways: Adaptive Immune System, Cell adhesion molecules - Homo sapiens (human), Co-stimulation by ICOS, Immune System, Intestinal immune network for IgA production - Homo sapiens (human), Regulation of T cell activation by CD28 family, the co-stimulatory signal during t-cell activation
UniProt: O75144
Entrez ID: 23308
|
Does Activation of RRM2 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
RRM2
|
response to virus
|
Hepatoma Cell Line
|
Gene: RRM2 (ribonucleotide reductase regulatory subunit M2)
Type: protein-coding
Summary: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: 2'-deoxyribonucleotide biosynthetic process, blastocyst development, deoxyribonucleotide biosynthetic process, deoxyribonucleotide metabolic process, positive regulation of G1/S transition of mitotic cell cycle, positive regulation of mitotic cell cycle phase transition, protein heterotetramerization, ribonucleoside diphosphate metabolic process; MF: ferric iron binding, identical protein binding, metal ion binding, oxidoreductase activity, protein binding, protein homodimerization activity, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; CC: cytoplasm, cytosol, nucleoplasm, nucleus, ribonucleoside-diphosphate reductase complex
Pathways: AICA-Ribosiduria, Adenine phosphoribosyltransferase deficiency (APRT), Adenosine Deaminase Deficiency, Adenylosuccinate Lyase Deficiency, Azathioprine Action Pathway, Beta Ureidopropionase Deficiency, Cell Cycle, Cell Cycle, Mitotic, Dihydropyrimidinase Deficiency, Drug metabolism - other enzymes - Homo sapiens (human), E2F transcription factor network, Fluoropyrimidine Activity, G1/S Transition, G1/S-Specific Transcription, Gemcitabine Action Pathway, Gemcitabine Metabolism Pathway, Gene expression (Transcription), Generic Transcription Pathway, Glutathione metabolism - Homo sapiens (human), Gout or Kelley-Seegmiller Syndrome, Hepatitis C and Hepatocellular Carcinoma, Interconversion of nucleotide di- and triphosphates, Lesch-Nyhan Syndrome (LNS), MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy), Mercaptopurine Action Pathway, Metabolism, Metabolism of nucleotides, Mitochondrial DNA depletion syndrome, Mitotic G1 phase and G1/S transition, Molybdenum Cofactor Deficiency, Myoadenylate deaminase deficiency, Nucleotide metabolism, Purine Metabolism, Purine Nucleoside Phosphorylase Deficiency, Purine metabolism - Homo sapiens (human), Pyrimidine Metabolism, Pyrimidine metabolism, Pyrimidine metabolism - Homo sapiens (human), RNA Polymerase II Transcription, Retinoblastoma gene in cancer, Thioguanine Action Pathway, Transcriptional Regulation by E2F6, UMP Synthase Deiciency (Orotic Aciduria), Xanthine Dehydrogenase Deficiency (Xanthinuria), Xanthinuria type I, Xanthinuria type II, adenosine deoxyribonucleotides <i>de novo</i> biosynthesis, guanosine deoxyribonucleotides <i>de novo</i> biosynthesis, guanosine nucleotides <i>de novo</i> biosynthesis, p53 signaling pathway - Homo sapiens (human), purine nucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis, pyrimidine deoxyribonucleotides biosynthesis from CTP, superpathway of purine nucleotide salvage, superpathway of pyrimidine deoxyribonucleotides <i>de novo</i> biosynthesis
UniProt: P31350
Entrez ID: 6241
|
Does Knockout of NUP88 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
NUP88
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: NUP88 (nucleoporin 88)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, protein import into nucleus, protein transport, ribosomal large subunit export from nucleus, ribosomal small subunit export from nucleus; MF: protein binding, structural constituent of nuclear pore; CC: cytosol, nuclear envelope, nuclear pore, nucleoplasm, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Ciliary landscape, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q99567
Entrez ID: 4927
|
Does Knockout of HOXD13 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
HOXD13
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: HOXD13 (homeobox D13)
Type: protein-coding
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anterior/posterior pattern specification, branch elongation of an epithelium, embryonic digit morphogenesis, embryonic hindgut morphogenesis, embryonic limb morphogenesis, gland morphogenesis, limb morphogenesis, male genitalia development, morphogenesis of an epithelial fold, pattern specification process, positive regulation of transcription by RNA polymerase II, prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis, prostate gland development, regulation of DNA-templated transcription, regulation of branching involved in prostate gland morphogenesis, regulation of cell population proliferation, regulation of transcription by RNA polymerase II, response to testosterone, skeletal system development, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways:
UniProt: P35453
Entrez ID: 3239
|
Does Knockout of RHOA in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
RHOA
|
cell proliferation
|
T-lymphoma cell line
|
Gene: RHOA (ras homolog family member A)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: Rho protein signal transduction, Roundabout signaling pathway, Wnt signaling pathway, planar cell polarity pathway, actin cytoskeleton organization, alpha-beta T cell lineage commitment, androgen receptor signaling pathway, angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure, aortic valve formation, apical junction assembly, apolipoprotein A-I-mediated signaling pathway, beta selection, bone trabecula morphogenesis, cell adhesion, cell differentiation, cell division, cell junction assembly, cell migration, cell morphogenesis, cell-matrix adhesion, cellular response to chemokine, cellular response to cytokine stimulus, cellular response to lipopolysaccharide, cerebral cortex cell migration, cleavage furrow formation, cytoplasmic microtubule organization, cytoskeleton organization, endothelial cell migration, endothelial tube lumen extension, establishment of epithelial cell apical/basal polarity, forebrain radial glial cell differentiation, kidney development, mitotic cleavage furrow formation, mitotic cytokinesis, mitotic spindle assembly, motor neuron apoptotic process, negative chemotaxis, negative regulation of cell migration involved in sprouting angiogenesis, negative regulation of cell size, negative regulation of cell-substrate adhesion, negative regulation of intracellular steroid hormone receptor signaling pathway, negative regulation of motor neuron apoptotic process, negative regulation of oxidative phosphorylation, negative regulation of reactive oxygen species biosynthetic process, neuron migration, odontogenesis, ossification involved in bone maturation, positive regulation of T cell migration, positive regulation of alpha-beta T cell differentiation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cell migration, positive regulation of cytokinesis, positive regulation of leukocyte adhesion to vascular endothelial cell, positive regulation of lipase activity, positive regulation of neuron differentiation, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of podosome assembly, positive regulation of protein serine/threonine kinase activity, positive regulation of stress fiber assembly, positive regulation of vascular associated smooth muscle contraction, regulation of actin cytoskeleton organization, regulation of cell migration, regulation of focal adhesion assembly, regulation of microtubule cytoskeleton organization, regulation of modification of postsynaptic actin cytoskeleton, regulation of modification of postsynaptic structure, regulation of neural precursor cell proliferation, regulation of neuron projection development, regulation of osteoblast proliferation, regulation of systemic arterial blood pressure by endothelin, regulation of transcription by RNA polymerase II, semaphorin-plexin signaling pathway, skeletal muscle satellite cell migration, skeletal muscle tissue development, small GTPase-mediated signal transduction, stress fiber assembly, substantia nigra development, substrate adhesion-dependent cell spreading, wound healing, spreading of cells; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, myosin binding, nucleotide binding, protein binding, protein kinase binding; CC: apical junction complex, cell cortex, cell junction, cell periphery, cell projection, cleavage furrow, cytoplasm, cytoplasmic side of plasma membrane, cytoskeleton, cytosol, dendrite, dendritic spine, endoplasmic reticulum membrane, endosome, extracellular exosome, ficolin-1-rich granule membrane, focal adhesion, glutamatergic synapse, lamellipodium, membrane, midbody, nucleus, plasma membrane, postsynapse, ruffle membrane, secretory granule membrane, vesicle
Pathways: AGE-RAGE pathway, Adherens junction - Homo sapiens (human), Airway smooth muscle cell contraction, Alpha 6 Beta 4 signaling pathway, Alpha6Beta4Integrin, Androgen receptor signaling pathway, Arf6 downstream pathway, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Aurora B signaling, Axon guidance, Axon guidance - Homo sapiens (human), Axonal growth inhibition (RHOA activation), Axonal growth stimulation, Bacterial invasion of epithelial cells - Homo sapiens (human), Beta-catenin independent WNT signaling, C-type lectin receptor signaling pathway - Homo sapiens (human), CXCR4-mediated signaling events, Cell migration and invasion through p75NTR, Chemokine signaling pathway - Homo sapiens (human), Chromosomal and microsatellite instability in colorectal cancer, Class I PI3K signaling events, Colorectal cancer - Homo sapiens (human), Corticotropin-releasing hormone signaling pathway, DNA damage response (only ATM dependent), Death Receptor Signaling, Deubiquitination, Developmental Biology, E-cadherin signaling in keratinocytes, E-cadherin signaling in the nascent adherens junction, EGFR1, EPH-Ephrin signaling, EPHA forward signaling, EPHA-mediated growth cone collapse, EPHA2 forward signaling, EPHB-mediated forward signaling, ERBB2 Regulates Cell Motility, Ebola Virus Pathway on Host, Endocytosis - Homo sapiens (human), Endogenous TLR signaling, Endothelins, Envelope proteins and their potential roles in EDMD physiopathology, Fibrin Complement Receptor 3 Signaling Pathway, Fluid shear stress and atherosclerosis - Homo sapiens (human), Focal Adhesion, Focal adhesion - Homo sapiens (human), G Protein Signaling Pathways, G alpha (12/13) signalling events, G beta:gamma signalling through PI3Kgamma, G-protein beta:gamma signalling, G13 Signaling Pathway, GPCR downstream signalling, GPVI-mediated activation cascade, Gastrin signaling pathway, Hemostasis, Human cytomegalovirus infection - Homo sapiens (human), Hypothetical Craniofacial Development Pathway, IL2-mediated signaling events, Immune System, Innate Immune System, Integrins in angiogenesis, Joubert Syndrome, LPA receptor mediated events, Leptin signaling pathway, Leukocyte transendothelial migration - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), Lissencephaly gene (LIS1) in neuronal migration and development, MAP3K1 role in promoting and blocking gonadal determination, Metabolism of proteins, MicroRNAs in cancer - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, N-cadherin signaling events, NOD-like receptor signaling pathway - Homo sapiens (human), Nervous system development, Netrin-UNC5B signaling pathway, Netrin-mediated signaling events, Neural Crest Cell Migration during Development, Neural Crest Cell Migration in Cancer, Neurotrophic factor-mediated Trk receptor signaling, Neurotrophin signaling pathway - Homo sapiens (human), Neutrophil degranulation, Noncanonical Wnt signaling pathway, Osteopontin-mediated events, Ovarian tumor domain proteases, Overview of leukocyte-intrinsic Hippo pathway functions, Oxytocin signaling pathway - Homo sapiens (human), PAR1-mediated thrombin signaling events, PAR4-mediated thrombin signaling events, PCP/CE pathway, PDGFR-beta signaling pathway, PI3K/AKT activation, PLK1 signaling events, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, Pancreatic adenocarcinoma pathway, Pancreatic secretion - Homo sapiens (human), Parathyroid hormone synthesis, secretion and action - Homo sapiens (human), Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways Regulating Hippo Signaling, Pathways in cancer - Homo sapiens (human), Pertussis - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Physiological and pathological hypertrophy of the heart, Plasma membrane estrogen receptor signaling, Platelet activation - Homo sapiens (human), Platelet activation, signaling and aggregation, Post-translational protein modification, Proteoglycans in cancer - Homo sapiens (human), RAGE, RAS and bradykinin pathways in COVID-19, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RHO GTPases Activate ROCKs, RHO GTPases Activate Rhotekin and Rhophilins, RHO GTPases activate CIT, RHO GTPases activate KTN1, RHO GTPases activate PKNs, RHOA GTPase cycle, RHOC GTPase cycle, Rap1 signaling pathway - Homo sapiens (human), Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of RhoA activity, Regulation of actin cytoskeleton - Homo sapiens (human), RhoA signaling pathway, S1P1 pathway, S1P2 pathway, S1P3 pathway, S1P4 pathway, S1P5 pathway, SHP2 signaling, SLIT2:ROBO1 increases RHOA activity, Salmonella infection - Homo sapiens (human), Sema4D in semaphorin signaling, Sema4D induced cell migration and growth-cone collapse, Sema4D mediated inhibition of cell attachment and migration, Semaphorin interactions, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by ERBB2, Signaling by GPCR, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by VEGF, Signaling by WNT, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by PRL, Signaling events mediated by PTP1B, Signaling events mediated by VEGFR1 and VEGFR2, Signaling events mediated by focal adhesion kinase, Signaling events regulated by Ret tyrosine kinase, Sphingolipid signaling pathway - Homo sapiens (human), Spinal Cord Injury, Stabilization and expansion of the E-cadherin adherens junction, Syndecan-2-mediated signaling events, Syndecan-4-mediated signaling events, T cell receptor signaling pathway - Homo sapiens (human), TGF-beta Signaling Pathway, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, Thromboxane A2 receptor signaling, Tight junction - Homo sapiens (human), Tuberculosis - Homo sapiens (human), VEGFA-VEGFR2 Pathway, VEGFA-VEGFR2 Signaling Pathway, Vascular smooth muscle contraction - Homo sapiens (human), Viral carcinogenesis - Homo sapiens (human), Wnt, Wnt Signaling Pathway, Wnt signaling, Wnt signaling in kidney disease, Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, Yersinia infection - Homo sapiens (human), a4b7 Integrin signaling, amb2 Integrin signaling, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human), ccr3 signaling in eosinophils, d4gdi signaling pathway, erk and pi-3 kinase are necessary for collagen binding in corneal epithelia, influence of ras and rho proteins on g1 to s transition, integrin signaling pathway, mBDNF and proBDNF regulation of GABA neurotransmission, mTOR signaling pathway - Homo sapiens (human), p75 NTR receptor-mediated signalling, p75(NTR)-mediated signaling, p75NTR regulates axonogenesis, protein kinase a at the centrosome, ras signaling pathway, rho cell motility signaling pathway, rho-selective guanine exchange factor akap13 mediates stress fiber formation, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, role of mal in rho-mediated activation of srf, role of pi3k subunit p85 in regulation of actin organization and cell migration, thrombin signaling and protease-activated receptors, trefoil factors initiate mucosal healing, ucalpain and friends in cell spread
UniProt: P61586
Entrez ID: 387
|
Does Knockout of THG1L in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
THG1L
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: THG1L (tRNA-histidine guanylyltransferase 1 like)
Type: protein-coding
Summary: The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which could lead to renal fibrosis. Another function of this protein is that of a guanyltransferase, adding GMP to the 5' end of tRNA(His). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: mitochondrial fusion, protein homotetramerization, response to oxidative stress, stress-induced mitochondrial fusion, tRNA 5'-end processing, tRNA modification, tRNA processing; MF: ATP binding, GTP binding, guanyl-nucleotide exchange factor activity, identical protein binding, magnesium ion binding, metal ion binding, nucleotide binding, nucleotidyltransferase activity, protein binding, tRNA binding, tRNA guanylyltransferase activity, transferase activity; CC: cytoplasm, cytosol, membrane, mitochondrial outer membrane, mitochondrion, transferase complex
Pathways: Metabolism of RNA, tRNA modification in the nucleus and cytosol, tRNA processing
UniProt: Q9NWX6
Entrez ID: 54974
|
Does Knockout of PDE4DIP in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
PDE4DIP
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: PDE4DIP (phosphodiesterase 4D interacting protein)
Type: protein-coding
Summary: The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: astral microtubule organization, centrosome cycle, positive regulation of microtubule nucleation, protein-containing complex assembly, regulation of Golgi organization; MF: enzyme binding, molecular adaptor activity, protein binding; CC: Golgi apparatus, centrosome, cortical microtubule plus-end, cytoplasm, cytoskeleton, microtubule organizing center, myofibril, nucleus
Pathways: VEGFA-VEGFR2 Signaling Pathway
UniProt: Q5VU43
Entrez ID: 9659
|
Does Knockout of CSMD1 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
CSMD1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: CSMD1 (CUB and Sushi multiple domains 1)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including learning or memory; mammary gland branching involved in pregnancy; and reproductive structure development. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: conditioned place preference, female gonad development, gene expression, glucose homeostasis, male gonad development, mammary gland branching involved in pregnancy, mammary gland development, mammary gland duct morphogenesis, memory, oviduct epithelium development, startle response
Pathways:
UniProt: Q96PZ7
Entrez ID: 64478
|
Does Activation of SMARCAD1 in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
SMARCAD1
|
protein/peptide accumulation
|
T cell
|
Gene: SMARCAD1 (SNF2 related chromatin remodeling ATPase with DExD box 1)
Type: protein-coding
Summary: This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA repair, chromatin organization, chromatin remodeling, chromosome separation, heterochromatin formation, positive regulation of transcription by RNA polymerase II, regulation of DNA recombination; MF: ATP binding, ATP hydrolysis activity, ATP-dependent chromatin remodeler activity, DNA binding, chromatin binding, helicase activity, hydrolase activity, nucleosome array spacer activity, nucleotide binding, protein binding, ubiquitin binding; CC: chromatin, chromosome, heterochromatin, nuclear replication fork, nucleoplasm, nucleus, site of double-strand break
Pathways: Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
UniProt: Q9H4L7
Entrez ID: 56916
|
Does Knockout of RAB33B in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
RAB33B
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: RAB33B (RAB33B, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit effector proteins in the GTP-bound state and inactive cytosolic proteins when in a GDP-bound state. The protein encoded by this gene is ubiquitously expressed and has been implicated in Golgi to endoplasmic reticulum cycling of Golgi enzymes. In addition, this protein regulates Golgi homeostasis and coordinates intra-Golgi retrograde trafficking. Allelic variants in this gene have been associated with Dyggve-Melchior-Clausen syndrome and Smith-McCort dysplasia 2, which are autosomal recessive spondyloepimetaphyseal dysplasias characterized by skeletal abnormalities. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: Rab protein signal transduction, autophagosome assembly, autophagy, intra-Golgi vesicle-mediated transport, negative regulation of constitutive secretory pathway, protein localization to Golgi apparatus, protein localization to phagophore assembly site, protein transport, regulation of Golgi organization, regulation of cell growth, regulation of epithelial cell proliferation, regulation of exocytosis, regulation of retrograde vesicle-mediated transport, Golgi to ER, skeletal system morphogenesis; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi lumen, Golgi membrane, endosome, membrane, phagophore assembly site membrane, presynapse
Pathways: Autophagy - animal - Homo sapiens (human), Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB geranylgeranylation, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q9H082
Entrez ID: 83452
|
Does Knockout of TRNT1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
TRNT1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TRNT1 (tRNA nucleotidyl transferase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CCA to the 3' terminus of tRNA molecules. Mutations in this gene result in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014].
Gene Ontology: BP: RNA processing, mitochondrial tRNA 3'-end processing, rescue of stalled ribosome, tRNA 3'-end processing, tRNA 3'-terminal CCA addition, tRNA processing, tRNA surveillance; MF: 5'-3' RNA polymerase activity, ATP binding, CCA tRNA nucleotidyltransferase activity, CCACCA tRNA nucleotidyltransferase activity, RNA binding, metal ion binding, nucleotide binding, nucleotidyltransferase activity, protein binding, protein homodimerization activity, tRNA binding, transferase activity; CC: cytoplasm, cytosol, mitochondrial matrix, mitochondrion, nucleoplasm, nucleus
Pathways: RNA transport - Homo sapiens (human)
UniProt: Q96Q11
Entrez ID: 51095
|
Does Knockout of DNMT3A in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
DNMT3A
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: DNMT3A (DNA methyltransferase 3 alpha)
Type: protein-coding
Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, autosome genomic imprinting, cellular response to amino acid stimulus, cellular response to bisphenol A, cellular response to ethanol, cellular response to hypoxia, chromatin organization, epigenetic programming of gene expression, genomic imprinting, hepatocyte apoptotic process, heterochromatin formation, methylation, negative regulation of DNA-templated transcription, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, neuron differentiation, positive regulation of cellular response to hypoxia, post-embryonic development, regulation of gene expression, regulatory ncRNA-mediated heterochromatin formation, response to cocaine, response to estradiol, response to ethanol, response to ionizing radiation, response to lead ion, response to nutrient levels, response to toxic substance, response to vitamin A, response to xenobiotic stimulus, spermatogenesis, transposable element silencing by piRNA-mediated DNA methylation; MF: DNA (cytosine-5-)-methyltransferase activity, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, identical protein binding, lncRNA binding, metal ion binding, methyltransferase activity, protein binding, protein-cysteine methyltransferase activity, transcription corepressor activity, transferase activity, unmethylated CpG binding, zinc ion binding; CC: XY body, catalytic complex, chromosome, chromosome, centromeric region, cytoplasm, euchromatin, heterochromatin, nuclear matrix, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, Cysteine and methionine metabolism - Homo sapiens (human), DNA methylation, Defective pyroptosis, Disease, Diseases of programmed cell death, Epigenetic regulation of gene expression, Gene expression (Transcription), Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex, MTHFR deficiency, Metabolism of proteins, MicroRNAs in cancer - Homo sapiens (human), One-carbon metabolism, One-carbon metabolism and related pathways, PRC2 methylates histones and DNA, Post-translational protein modification, RMTs methylate histone arginines, Regulation of endogenous retroelements, Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs), SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA methylation proteins, Trans-sulfuration and one-carbon metabolism, Validated targets of C-MYC transcriptional repression
UniProt: Q9Y6K1
Entrez ID: 1788
|
Does Knockout of OPA3 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
OPA3
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3)
Type: protein-coding
Summary: The mouse ortholog of this protein co-purifies with the mitochondrial inner membrane. Mutations in this gene have been shown to result in 3-methylglutaconic aciduria type III and autosomal dominant optic atrophy and cataract. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: bone development, fat cell differentiation, mitochondrion organization, neuromuscular process, regulation of growth, regulation of lipid metabolic process, visual perception; CC: mitochondrion
Pathways:
UniProt: Q9H6K4
Entrez ID: 80207
|
Does Knockout of ADRA1D in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
ADRA1D
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ADRA1D (adrenoceptor alpha 1D)
Type: protein-coding
Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenylate cyclase-activating adrenergic receptor signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, cell-cell signaling, neuron-glial cell signaling, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of cell population proliferation, positive regulation of cytosolic calcium ion concentration, positive regulation of vasoconstriction, signal transduction; MF: G protein-coupled receptor activity, adrenergic receptor activity, alpha1-adrenergic receptor activity, identical protein binding, protein binding; CC: membrane, plasma membrane
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Adrenoceptors, Amine ligand-binding receptors, Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Class A/1 (Rhodopsin-like receptors), G alpha (12/13) signalling events, G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, GPCRs, Other, Monoamine GPCRs, Neuroactive ligand-receptor interaction - Homo sapiens (human), Salivary secretion - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Vascular smooth muscle contraction - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: P25100
Entrez ID: 146
|
Does Knockout of EXOSC10 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
EXOSC10
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: EXOSC10 (exosome component 10)
Type: protein-coding
Summary: Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via telomerase. Located in cytosol; nuclear lumen; and transcriptionally active chromatin. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CUT catabolic process, DNA damage response, DNA repair, RNA catabolic process, RNA processing, TRAMP-dependent tRNA surveillance pathway, exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), histone mRNA catabolic process, maturation of 5.8S rRNA, negative regulation of telomere maintenance via telomerase, nuclear mRNA surveillance, nuclear polyadenylation-dependent CUT catabolic process, nuclear polyadenylation-dependent antisense transcript catabolic process, nuclear polyadenylation-dependent rRNA catabolic process, nuclear polyadenylation-dependent snRNA catabolic process, nuclear polyadenylation-dependent snoRNA catabolic process, nuclear-transcribed mRNA catabolic process, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, nucleobase-containing compound metabolic process, poly(A)-dependent snoRNA 3'-end processing, positive regulation of mRNA cis splicing, via spliceosome, rRNA processing, regulation of gene expression, regulation of nucleobase-containing compound metabolic process, regulation of telomerase RNA localization to Cajal body, ribosomal small subunit biogenesis; MF: 3'-5' exonuclease activity, 3'-5'-RNA exonuclease activity, RNA binding, RNA exonuclease activity, exonuclease activity, hydrolase activity, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, protein binding, single-stranded RNA binding, telomerase RNA binding; CC: cytoplasm, cytoplasmic exosome (RNase complex), cytosol, euchromatin, exosome (RNase complex), membrane, nuclear exosome (RNase complex), nucleolar exosome (RNase complex), nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Nuclear RNA decay, RNA degradation - Homo sapiens (human), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q01780
Entrez ID: 5394
|
Does Knockout of MICU2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
MICU2
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: MICU2 (mitochondrial calcium uptake 2)
Type: protein-coding
Summary: Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: calcium import into the mitochondrion, cellular response to calcium ion, mitochondrial calcium ion homeostasis, mitochondrial calcium ion transmembrane transport, negative regulation of mitochondrial calcium ion concentration, positive regulation of mitochondrial calcium ion concentration; MF: calcium channel regulator activity, calcium ion binding, calcium ion sensor activity, protein binding, protein heterodimerization activity; CC: calcium channel complex, membrane, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrion, uniplex complex
Pathways: Metabolism of proteins, Mitochondrial calcium ion transport, Mitochondrial protein degradation, Processing of SMDT1, Transport of small molecules
UniProt: Q8IYU8
Entrez ID: 221154
|
Does Knockout of PSMD4 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
PSMD4
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process; MF: RNA binding, identical protein binding, molecular adaptor activity, polyubiquitin modification-dependent protein binding, protein binding; CC: cytosol, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, base subcomplex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), ID, Metabolism of proteins, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Proteasome assembly, Spinocerebellar ataxia - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, proteasome complex
UniProt: P55036
Entrez ID: 5710
|
Does Knockout of HNRNPL in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
HNRNPL
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: HNRNPL (heterogeneous nuclear ribonucleoprotein L)
Type: protein-coding
Summary: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA processing, mRNA processing, negative regulation of DNA-templated transcription, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, pre-mRNA intronic binding, protein binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, extracellular exosome, membrane, nucleoplasm, nucleus, pronucleus, ribonucleoprotein complex, ribonucleoprotein granule, synapse
Pathways: mRNA Processing
UniProt: P14866
Entrez ID: 3191
|
Does Knockout of WNT7B in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
WNT7B
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: WNT7B (Wnt family member 7B)
Type: protein-coding
Summary: This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, animal organ development, canonical Wnt signaling pathway, cell differentiation, cell fate commitment, cellular response to retinoic acid, central nervous system vasculogenesis, chemoattraction of dopaminergic neuron axon, chorio-allantoic fusion, developmental growth involved in morphogenesis, embryonic organ development, embryonic placenta morphogenesis, establishment or maintenance of polarity of embryonic epithelium, fibroblast proliferation, forebrain regionalization, homeostatic process, in utero embryonic development, inner medullary collecting duct development, intracellular oxygen homeostasis, lens fiber cell development, lobar bronchus development, lung development, lung epithelium development, lung morphogenesis, mammary gland epithelium development, metanephric collecting duct development, metanephric epithelium development, metanephric loop of Henle development, metanephros morphogenesis, neuron differentiation, neuron projection development, neuron projection morphogenesis, outer medullary collecting duct development, positive regulation of JNK cascade, positive regulation of osteoblast differentiation, regulation of cell projection size, renal inner medulla development, renal outer medulla development, response to glucocorticoid, stem cell proliferation, synapse organization, system development, tissue development, trachea cartilage morphogenesis; MF: cytokine activity, frizzled binding, protein binding, receptor ligand activity, signaling receptor binding; CC: Golgi lumen, endocytic vesicle membrane, endoplasmic reticulum lumen, extracellular exosome, extracellular region, extracellular space, plasma membrane
Pathways: Alzheimer disease - Homo sapiens (human), Basal cell carcinoma - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, Class B/2 (Secretin family receptors), Cushing syndrome - Homo sapiens (human), DNA damage response (only ATM dependent), Differentiation Pathway, ESC Pluripotency Pathways, Epithelial to mesenchymal transition in colorectal cancer, GPCR ligand binding, Gastric cancer - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), LncRNA involvement in canonical Wnt signaling and colorectal cancer, Melanogenesis - Homo sapiens (human), Osteoblast differentiation, Pathways in cancer - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), Signal Transduction, Signaling by GPCR, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), The Overlap Between Signal Transduction Pathways that Contribute to a Range of LMNA Laminopathies, WNT ligand biogenesis and trafficking, Wnt signaling, Wnt signaling in kidney disease, Wnt signaling network, Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, mTOR signaling pathway - Homo sapiens (human), ncRNAs involved in Wnt signaling in hepatocellular carcinoma
UniProt: P56706
Entrez ID: 7477
|
Does Knockout of LMX1A in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
LMX1A
|
response to virus
|
Lung Cancer Cell Line
|
Gene: LMX1A (LIM homeobox transcription factor 1 alpha)
Type: protein-coding
Summary: This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: axon guidance, central nervous system development, central nervous system neuron differentiation, cerebellum development, dentate gyrus development, dopaminergic neuron differentiation, hippocampus development, locomotory behavior, memory, midbrain development, midbrain dopaminergic neuron differentiation, negative regulation of neuron differentiation, neuron differentiation, olfactory behavior, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell growth, regulation of gene expression, regulation of transcription by RNA polymerase II, synapse organization; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways: Dopaminergic Neurogenesis
UniProt: Q8TE12
Entrez ID: 4009
|
Does Knockout of ARSJ in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
ARSJ
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ARSJ (arylsulfatase family member J)
Type: protein-coding
Summary: Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008].
Gene Ontology: MF: arylsulfatase activity, hydrolase activity, metal ion binding, sulfuric ester hydrolase activity; CC: actin cytoskeleton, endoplasmic reticulum lumen, extracellular region
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Metabolism of proteins, Post-translational protein modification, Sphingolipid metabolism, The activation of arylsulfatases
UniProt: Q5FYB0
Entrez ID: 79642
|
Does Knockout of USP19 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
USP19
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: USP19 (ubiquitin specific peptidase 19)
Type: protein-coding
Summary: Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017].
Gene Ontology: BP: ERAD pathway, negative regulation of skeletal muscle tissue development, positive regulation of cell cycle process, protein deubiquitination, protein stabilization, proteolysis, regulation of ERAD pathway, regulation of cellular response to hypoxia, regulation of protein stability, response to endoplasmic reticulum stress; MF: Hsp90 protein binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity, protein binding, zinc ion binding; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: O94966
Entrez ID: 10869
|
Does Knockout of RICTOR in Cancer Cell Line causally result in cell proliferation?
| 0
| 193
|
Knockout
|
RICTOR
|
cell proliferation
|
Cancer Cell Line
|
Gene: RICTOR (RPTOR independent companion of MTOR complex 2)
Type: protein-coding
Summary: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: TOR signaling, TORC2 signaling, actin cytoskeleton organization, cGAS/STING signaling pathway, cellular response to nutrient levels, cytoskeleton organization, embryo development ending in birth or egg hatching, lipid biosynthetic process, negative regulation of apoptotic process, negative regulation of cGAS/STING signaling pathway, phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of TOR signaling, positive regulation of actin filament polymerization, positive regulation of cell growth, positive regulation of cell migration, positive regulation of endothelial cell proliferation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, regulation of actin cytoskeleton organization, regulation of establishment of cell polarity, regulation of gene expression, regulation of inflammatory response, regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; MF: ATP binding, enzyme-substrate adaptor activity, molecular adaptor activity, nucleotide binding, protein binding, protein kinase binding, protein serine/threonine kinase activator activity, ribosome binding, zinc ion binding; CC: Golgi apparatus, TORC2 complex, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, lysosomal membrane, lysosome, membrane, plasma membrane, serine/threonine protein kinase complex
Pathways: Adaptive Immune System, Angiopoietin Like Protein 8 Regulatory Pathway, CD28 dependent PI3K/Akt signaling, CXCR3-mediated signaling events, CXCR4-mediated signaling events, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Class I PI3K signaling events mediated by Akt, Co-stimulation by CD28, Constitutive Signaling by AKT1 E17K in Cancer, Disease, Diseases of signal transduction by growth factor receptors and second messengers, EGF-EGFR signaling pathway, EGFR1, ErbB1 downstream signaling, Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling, Gene expression (Transcription), Generic Transcription Pathway, Ghrelin, Head and Neck Squamous Cell Carcinoma, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Immune System, Integrin-linked kinase signaling, Intracellular signaling by second messengers, Oncostatin M Signaling Pathway, Oncostatin_M, PI3K-AKT-mTOR signaling pathway and therapeutic opportunities, PI3K/AKT Signaling in Cancer, PIP3 activates AKT signaling, RNA Polymerase II Transcription, Regulation of T cell activation by CD28 family, Regulation of TP53 Activity, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulatory circuits of the STAT3 signaling pathway, Response of endothelial cells to shear stress, Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by VEGF, Target Of Rapamycin (TOR) Signaling, Transcriptional Regulation by TP53, VEGFA-VEGFR2 Pathway, VEGFA-VEGFR2 Signaling Pathway, VEGFR2 mediated vascular permeability, mTOR signaling pathway, mTOR signaling pathway - Homo sapiens (human)
UniProt: Q6R327
Entrez ID: 253260
|
Does Knockout of GLIPR1L1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
GLIPR1L1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: GLIPR1L1 (GLIPR1 like 1)
Type: protein-coding
Summary: Predicted to be involved in single fertilization. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in sperm connecting piece. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: fusion of sperm to egg plasma membrane involved in single fertilization, sexual reproduction, single fertilization; CC: acrosomal vesicle, cytoplasmic vesicle, extracellular region, extracellular space, membrane, membrane raft, plasma membrane, protein complex involved in cell-cell adhesion, side of membrane
Pathways:
UniProt: Q6UWM5
Entrez ID: 256710
|
Does Knockout of RTF1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
RTF1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: RTF1 (RTF1 homolog, Paf1/RNA polymerase II complex component)
Type: protein-coding
Summary: This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: Wnt signaling pathway, blastocyst growth, chromatin organization, endodermal cell fate commitment, negative regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: DNA binding, RNA binding, protein binding, single-stranded DNA binding; CC: Cdc73/Paf1 complex, nucleolus, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Endoderm differentiation, Formation of RNA Pol II elongation complex , Gene expression (Transcription), Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation
UniProt: Q92541
Entrez ID: 23168
|
Does Knockout of NADK2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
NADK2
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: NADK2 (NAD kinase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: NAD+ metabolic process, NADP+ biosynthetic process; MF: ATP binding, NAD+ kinase activity, kinase activity, nucleotide binding, phosphotransferase activity, alcohol group as acceptor, protein homodimerization activity, transferase activity; CC: mitochondrial matrix, mitochondrion
Pathways: Metabolism, Metabolism of proteins, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Mitochondrial protein degradation, Nicotinate and nicotinamide metabolism - Homo sapiens (human), Nicotinate metabolism
UniProt: Q4G0N4
Entrez ID: 133686
|
Does Knockout of OR4S2 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
OR4S2
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: OR4S2 (olfactory receptor family 4 subfamily S member 2)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NH73
Entrez ID: 219431
|
Does Knockout of PPIE in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
PPIE
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: PPIE (peptidylprolyl isomerase E)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, positive regulation of viral genome replication, protein folding, regulation of DNA-templated transcription; MF: RNA binding, cyclosporin A binding, isomerase activity, mRNA binding, nucleic acid binding, peptidyl-prolyl cis-trans isomerase activity, poly(A) binding, protein binding; CC: U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, cytoplasm, cytosol, extracellular region, ficolin-1-rich granule lumen, intracellular membrane-bounded organelle, nuclear speck, nucleoplasm, nucleus, protein-containing complex, secretory granule lumen, spliceosomal complex
Pathways: DNA Repair, Dual incision in TC-NER, Formation of TC-NER Pre-Incision Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Immune System, Innate Immune System, Metabolism of RNA, Neutrophil degranulation, Nucleotide Excision Repair, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), Transcription-Coupled Nucleotide Excision Repair (TC-NER), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9UNP9
Entrez ID: 10450
|
Does Knockout of TUBGCP6 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
TUBGCP6
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: TUBGCP6 (tubulin gamma complex component 6)
Type: protein-coding
Summary: The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic microtubule organization, meiotic cell cycle, microtubule cytoskeleton organization, microtubule nucleation, mitotic cell cycle, spindle assembly; MF: gamma-tubulin binding, microtubule binding, microtubule minus-end binding; CC: centrosome, cytoplasm, cytoskeleton, cytosol, gamma-tubulin complex, gamma-tubulin ring complex, membrane, microtubule, microtubule organizing center, spindle pole
Pathways: 15q11.2 copy number variation syndrome, Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: Q96RT7
Entrez ID: 85378
|
Does Knockout of MRE11 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
MRE11
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: MRE11 (MRE11 double strand break repair nuclease)
Type: protein-coding
Summary: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA double-strand break processing, DNA recombination, DNA repair, DNA strand resection involved in replication fork processing, R-loop processing, cell population proliferation, chromosome organization, double-strand break repair, double-strand break repair via homologous recombination, double-strand break repair via nonhomologous end joining, homologous chromosome pairing at meiosis, homologous recombination, meiotic DNA double-strand break formation, meiotic cell cycle, mitochondrial double-strand break repair via homologous recombination, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, mitotic intra-S DNA damage checkpoint signaling, negative regulation of apoptotic process, negative regulation of double-strand break repair via nonhomologous end joining, positive regulation of double-strand break repair, positive regulation of telomere maintenance, reciprocal meiotic recombination, regulation of mitotic recombination, sister chromatid cohesion, telomere maintenance, telomere maintenance via telomerase, telomeric 3' overhang formation; MF: 3'-5' exonuclease activity, 3'-5'-DNA exonuclease activity, DNA binding, DNA endonuclease activity, DNA helicase activity, cadherin binding, double-stranded DNA binding, endonuclease activity, exonuclease activity, hydrolase activity, identical protein binding, manganese ion binding, nuclease activity, protein binding, single-stranded DNA endodeoxyribonuclease activity; CC: BRCA1-C complex, Mre11 complex, PML body, chromosomal region, chromosome, chromosome, telomeric region, cytoplasm, cytosol, nucleoplasm, nucleus, replication fork, site of double-strand break
Pathways: ATM Signaling Network in Development and Disease, ATM pathway, BARD1 signaling events, Breast cancer pathway, Cell Cycle, Cell Cycle Checkpoints, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , DDX1 as a regulatory component of the Drosha microprocessor, DNA Damage/Telomere Stress Induced Senescence, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, DNA Repair Pathways Full Network, DNA damage response, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function, Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function, Defective homologous recombination repair (HRR) due to BRCA1 loss of function, Defective homologous recombination repair (HRR) due to BRCA2 loss of function, Defective homologous recombination repair (HRR) due to PALB2 loss of function, Disease, Diseases of DNA Double-Strand Break Repair, Diseases of DNA repair, Fanconi anemia pathway, G2/M Checkpoints, G2/M DNA damage checkpoint, Gene expression (Transcription), Generic Transcription Pathway, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through MMEJ (alt-NHEJ), HDR through Single Strand Annealing (SSA), Homologous DNA Pairing and Strand Exchange, Homologous recombination, Homologous recombination - Homo sapiens (human), Homology Directed Repair, IRF3-mediated induction of type I IFN, Immune System, Impaired BRCA2 binding to PALB2, Impaired BRCA2 binding to RAD51, Innate Immune System, Joubert Syndrome, Meiosis, Meiotic recombination, Non-homologous end-joining - Homo sapiens (human), Nonhomologous End-Joining (NHEJ), Presynaptic phase of homologous DNA pairing and strand exchange, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Regulation of Telomerase, Reproduction, Resolution of D-Loop Structures, Resolution of D-loop Structures through Holliday Junction Intermediates, Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA), STING mediated induction of host immune responses, Sensing of DNA Double Strand Breaks, Transcriptional Regulation by TP53, Validated transcriptional targets of deltaNp63 isoforms, miRNA regulation of DNA damage response, role of brca1 brca2 and atr in cancer susceptibility
UniProt: P49959
Entrez ID: 4361
|
Does Knockout of TMED6 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
TMED6
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: TMED6 (transmembrane p24 trafficking protein 6)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: Golgi organization, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport; CC: COPII-coated ER to Golgi transport vesicle, Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, membrane
Pathways:
UniProt: Q8WW62
Entrez ID: 146456
|
Does Knockout of NHP2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
NHP2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: NHP2 (NHP2 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis, snoRNA guided rRNA pseudouridine synthesis, telomerase RNA localization to Cajal body, telomere maintenance via telomerase; MF: RNA binding, U3 snoRNA binding, box H/ACA snoRNA binding, mRNA 3'-UTR binding, protein binding, telomerase RNA binding; CC: Cajal body, box H/ACA scaRNP complex, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, chromosome, telomeric region, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Telomere Extension By Telomerase, Telomere Maintenance, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NX24
Entrez ID: 55651
|
Does Knockout of RBX1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
RBX1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: RBX1 (ring-box 1)
Type: protein-coding
Summary: This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010].
Gene Ontology: BP: DNA damage response, DNA damage response, signal transduction by p53 class mediator, DNA repair, G1/S transition of mitotic cell cycle, MAPK cascade, RNA polymerase II transcription initiation surveillance, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, T cell activation, TORC1 signaling, apoptotic process, autophagosome assembly, base-excision repair, AP site formation via deaminated base removal, cellular response to UV, cellular response to amino acid starvation, cellular response to amino acid stimulus, cellular response to chemical stress, cellular response to insulin stimulus, cellular response to nutrient levels, cellular response to oxidative stress, cytokine-mediated signaling pathway, epithelial to mesenchymal transition, insulin receptor signaling pathway, lysosome organization, miRNA-mediated gene silencing by mRNA destabilization, mitophagy, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of canonical NF-kappaB signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of insulin receptor signaling pathway, negative regulation of mitophagy, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, negative regulation of response to oxidative stress, negative regulation of signal transduction by p53 class mediator, negative regulation of type I interferon production, negative regulation of ubiquitin-dependent protein catabolic process, p38MAPK cascade, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of canonical NF-kappaB signal transduction, positive regulation of epithelial cell apoptotic process, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein autoubiquitination, positive regulation of protein catabolic process, positive regulation of transcription by RNA polymerase II, positive regulation of translation, positive regulation of type I interferon production, post-translational protein modification, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein catabolic process, protein monoubiquitination, protein neddylation, protein polyubiquitination, protein ubiquitination, regulation of cellular response to insulin stimulus, regulation of mitotic cell cycle, renal sodium ion absorption, response to oxidative stress, signal transduction in response to DNA damage, spermatogenesis, transcription by RNA polymerase II, transcription elongation by RNA polymerase II, transcription-coupled nucleotide-excision repair, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the C-end degron rule pathway; MF: NEDD8 ligase activity, NEDD8 transferase activity, RNA polymerase II-specific DNA-binding transcription factor binding, cullin family protein binding, metal ion binding, molecular adaptor activity, protein binding, protein-containing complex binding, transferase activity, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, ubiquitin-ubiquitin ligase activity, zinc ion binding; CC: Cul2-RING ubiquitin ligase complex, Cul3-RING ubiquitin ligase complex, Cul4-RING E3 ubiquitin ligase complex, Cul4A-RING E3 ubiquitin ligase complex, Cul4B-RING E3 ubiquitin ligase complex, Cul5-RING ubiquitin ligase complex, Cul7-RING ubiquitin ligase complex, SCF ubiquitin ligase complex, VCB complex, cullin-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus, site of DNA damage
Pathways: 22q11.2 copy number variation syndrome, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Axon guidance, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular response to chemical stress, Cellular response to hypoxia, Cellular responses to stimuli, Cellular responses to stress, Circadian clock, Circadian rhythm - Homo sapiens (human), Class I MHC mediated antigen processing & presentation, Co-inhibition by PD-1, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Cytokine Signaling in Immune system, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Repair, DNA Repair Pathways Full Network, DNA Replication, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual Incision in GG-NER, Dual hijack model of Vif in HIV infection, Dual incision in TC-NER, Evasion by RSV of host interferon responses, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FBXW7 Mutants and NOTCH1 in Cancer, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, G1/S DNA Damage Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIF-1 signaling pathway - Homo sapiens (human), HIV Infection, Hedgehog 'off' state, Hedgehog 'on' state, Hijack of ubiquitination by SARS-CoV-2, Hippo-Merlin Signaling Dysregulation, Host Interactions of HIV factors, Human immunodeficiency virus 1 infection - Homo sapiens (human), Hypoxic and oxygen homeostasis regulation of HIF-1-alpha, Immune System, Infectious disease, Interleukin-1 family signaling, Interleukin-1 signaling, KEAP1-NFE2L2 pathway, Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Metabolism of proteins, Mitotic G2-G2/M phases, NOTCH1 Intracellular Domain Regulates Transcription, NRF2-ARE regulation, Neddylation, Negative regulation of NOTCH4 signaling, Nervous system development, Notch, Nuclear events mediated by NFE2L2, Nuclear events stimulated by ALK signaling in cancer, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Orc1 removal from chromatin, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, Pathways in cancer - Homo sapiens (human), Post-translational protein modification, Potential therapeutics for SARS, Prolactin receptor signaling, Protein processing in endoplasmic reticulum - Homo sapiens (human), RAF/MAP kinase cascade, RNA Polymerase II Transcription, RSV-host interactions, Recognition of DNA damage by PCNA-containing replication complex, Regulation of BACH1 activity, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of T cell activation by CD28 family, Regulation of expression of SLITs and ROBOs, Renal cell carcinoma - Homo sapiens (human), Respiratory Syncytial Virus Infection Pathway, Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SARS-CoV Infections, SPOP-mediated proteasomal degradation of PD-L1(CD274), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Hedgehog, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH4, Signaling by ROBO receptors, Signaling by WNT, Switching of origins to a post-replicative state, Synthesis of DNA, TCF dependent signaling in response to WNT, TGF-beta Signaling Pathway, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional regulation by RUNX2, Translation, Type 2 papillary renal cell carcinoma, Ubiquitin mediated proteolysis - Homo sapiens (human), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Wnt signaling pathway - Homo sapiens (human), er associated degradation (erad) pathway, p53-Independent G1/S DNA Damage Checkpoint, regulation of p27 phosphorylation during cell cycle progression
UniProt: P62877
Entrez ID: 9978
|
Does Knockout of TANK in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
TANK
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TANK (TRAF family member associated NFKB activator)
Type: protein-coding
Summary: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: DNA damage response, cellular response to interleukin-1, cellular response to ionizing radiation, cellular response to tumor necrosis factor, defense response to virus, negative regulation of canonical NF-kappaB signal transduction, negative regulation of tumor necrosis factor-mediated signaling pathway, positive regulation of protein deubiquitination, positive regulation of type I interferon production, positive regulation of ubiquitin-specific protease activity, signal transduction, type I interferon-mediated signaling pathway; MF: cysteine-type deubiquitinase activity, deubiquitinase activator activity, metal ion binding, molecular adaptor activity, molecular function inhibitor activity, protein binding, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, cytosol, protein-containing complex, serine/threonine protein kinase complex
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Autophagy - animal - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), Novel intracellular components of RIG-I-like receptor (RLR) pathway, Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), RIG-I-like receptor signaling pathway - Homo sapiens (human), SARS-CoV-2 innate immunity evasion and cell-specific immune response, Structural Pathway of Interleukin 1 (IL-1), TNF-alpha signaling pathway, TNFalpha, tnf/stress related signaling, tnfr2 signaling pathway
UniProt: Q92844
Entrez ID: 10010
|
Does Activation of TAB3 in T cell causally result in protein/peptide accumulation?
| 1
| 2,426
|
Activation
|
TAB3
|
protein/peptide accumulation
|
T cell
|
Gene: TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3)
Type: protein-coding
Summary: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: canonical NF-kappaB signal transduction, defense response to bacterium, negative regulation of autophagy, negative regulation of canonical NF-kappaB signal transduction, non-canonical NF-kappaB signal transduction, p38MAPK cascade, positive regulation of canonical NF-kappaB signal transduction, response to bacterium; MF: K63-linked polyubiquitin modification-dependent protein binding, metal ion binding, molecular adaptor activity, protein binding, ubiquitin binding, zinc ion binding; CC: cytosol, endoplasmic reticulum, endosome membrane, extracellular exosome, plasma membrane
Pathways: Alpha-protein kinase 1 signaling pathway, C-type lectin receptors (CLRs), CLEC7A (Dectin-1) signaling, Cytokine Signaling in Immune system, Death Receptor Signaling, Disease, FCERI mediated NF-kB activation, Fc epsilon receptor (FCERI) signaling, IL-1 signaling pathway, IL-17 signaling pathway - Homo sapiens (human), IL1, IRAK2 mediated activation of TAK1 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, Immune System, Infectious disease, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, MAP kinase activation, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Homo sapiens (human), NOD-like receptor signaling pathway - Homo sapiens (human), NOD1/2 Signaling Pathway, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Pathogenic Escherichia coli infection - Homo sapiens (human), Regulation of toll-like receptor signaling pathway, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, Salmonella infection - Homo sapiens (human), Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by Interleukins, Structural Pathway of Interleukin 1 (IL-1), TAK1-dependent IKK and NF-kappa-B activation , TICAM1,TRAF6-dependent induction of TAK1 complex, TNF signaling, TNF signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, TNFR1-induced NF-kappa-B signaling pathway, TNFalpha, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like Receptor Signaling Pathway, Viral Infection Pathways, activated TAK1 mediates p38 MAPK activation
UniProt: Q8N5C8
Entrez ID: 257397
|
Does Knockout of ZCCHC13 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 1,246
|
Knockout
|
ZCCHC13
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ZCCHC13 (zinc finger CCHC-type containing 13)
Type: protein-coding
Summary: This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 3. However, the CDS of this intronless gene remains relatively intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. The encoded protein contains six CCHC-type zinc fingers, and is thus thought to function as a transcription factor. [provided by RefSeq, May 2010].
Gene Ontology: MF: mRNA binding, metal ion binding, nucleic acid binding, protein binding, single-stranded RNA binding, translation regulator activity, zinc ion binding
Pathways:
UniProt: Q8WW36
Entrez ID: 389874
|
Does Knockout of KRTCAP2 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
KRTCAP2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: KRTCAP2 (keratinocyte associated protein 2)
Type: protein-coding
Summary: Enables enzyme activator activity. Involved in protein N-linked glycosylation via arginine. Is active in oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; MF: enzyme activator activity, protein-macromolecule adaptor activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A
Pathways:
UniProt: Q8N6L1
Entrez ID: 200185
|
Does Knockout of LYSMD2 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
LYSMD2
|
response to chemicals
|
Melanoma Cell Line
|
Gene: LYSMD2 (LysM domain containing 2)
Type: protein-coding
Summary: LysM domain containing 2
Gene Ontology:
Pathways:
UniProt: Q8IV50
Entrez ID: 256586
|
Does Knockout of SYMPK in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
SYMPK
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: SYMPK (symplekin scaffold protein)
Type: protein-coding
Summary: This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, mRNA processing, negative regulation of protein binding; CC: anchoring junction, bicellular tight junction, cytoplasm, cytoskeleton, cytosol, mRNA cleavage and polyadenylation specificity factor complex, membrane, nuclear body, nuclear stress granule, nucleoplasm, nucleus, plasma membrane
Pathways: Tight junction - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q92797
Entrez ID: 8189
|
Does Knockout of WEE2 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
WEE2
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: WEE2 (WEE2 oocyte meiosis inhibiting kinase)
Type: protein-coding
Summary: Predicted to enable protein tyrosine kinase activity. Predicted to be involved in several processes, including female pronucleus assembly; negative regulation of oocyte maturation; and regulation of meiosis I. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: female meiotic nuclear division, female pronucleus assembly, meiotic cell cycle, mitotic cell cycle, negative regulation of oocyte maturation, positive regulation of phosphorylation, regulation of fertilization, regulation of meiosis I; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, plasma membrane
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human)
UniProt: P0C1S8
Entrez ID: 494551
|
Does Knockout of NOP10 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
NOP10
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: NOP10 (NOP10 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: pseudouridine synthesis, rRNA processing, rRNA pseudouridine synthesis, ribosome biogenesis, snRNA pseudouridine synthesis, telomerase RNA localization to Cajal body, telomere maintenance via telomerase; MF: RNA binding, box H/ACA snoRNA binding, protein binding, snoRNA binding, telomerase RNA binding; CC: Cajal body, box H/ACA scaRNP complex, box H/ACA snoRNP complex, box H/ACA telomerase RNP complex, nuclear body, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, sno(s)RNA-containing ribonucleoprotein complex, telomerase holoenzyme complex
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), Telomere Extension By Telomerase, Telomere Maintenance, rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9NPE3
Entrez ID: 55505
|
Does Knockout of PTBP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
PTBP1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PTBP1 (polypyrimidine tract binding protein 1)
Type: protein-coding
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: IRES-dependent viral translational initiation, RNA splicing, gene expression, mRNA processing, negative regulation of RNA splicing, negative regulation of mRNA metabolic process, negative regulation of mRNA splicing, via spliceosome, negative regulation of muscle cell differentiation, negative regulation of neuron differentiation, neurogenesis, positive regulation of calcineurin-NFAT signaling cascade, positive regulation of transcription by RNA polymerase II, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, regulation of cell differentiation; MF: RNA binding, mRNA binding, nucleic acid binding, poly-pyrimidine tract binding, pre-mRNA binding, protein binding; CC: extracellular exosome, membrane, nucleolus, nucleoplasm, nucleus
Pathways: FGFR2 alternative splicing, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Signal Transduction, Signaling by FGFR, Signaling by FGFR2, Signaling by Receptor Tyrosine Kinases, internal ribosome entry pathway, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mir-124 predicted interactions with cell cycle and differentiation
UniProt: P26599
Entrez ID: 5725
|
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