prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of ARHGEF11 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | ARHGEF11 | cell proliferation | Ovarian Cancer Cell Line | Gene: ARHGEF11 (Rho guanine nucleotide exchange factor 11)
Type: protein-coding
Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins an... |
Does Knockout of BIN1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | BIN1 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: BIN1 (bridging integrator 1)
Type: protein-coding
Summary: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system ma... |
Does Knockout of CORO6 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | CORO6 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: CORO6 (coronin 6)
Type: protein-coding
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: actin filament organization, cell migrat... |
Does Knockout of CLEC2A in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | CLEC2A | cell proliferation | Gastric Cancer Cell Line | Gene: CLEC2A (C-type lectin domain family 2 member A)
Type: protein-coding
Summary: CLEC2A belongs to the CLEC2 family of activation-induced, natural killer gene complex-encoded C-type lectin-like receptors (Spreu et al., 2007 [PubMed 18046548]).[supplied by OMIM, May 2008]
Gene Ontology: MF: c... |
Does Knockout of RAB11FIP1 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | RAB11FIP1 | cell proliferation | T-lymphoma cell line | Gene: RAB11FIP1 (RAB11 family interacting protein 1)
Type: protein-coding
Summary: This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of protein... |
Does Knockout of SON in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | SON | cell proliferation | Colorectal Cancer Cell Line | Gene: SON (SON DNA and RNA binding protein)
Type: protein-coding
Summary: This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequen... |
Does Activation of MAF in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | MAF | response to virus | Hepatoma Cell Line | Gene: MAF (MAF bZIP transcription factor)
Type: protein-coding
Summary: The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcri... |
Does Knockout of BRD4 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | BRD4 | cell proliferation | Endometrial Cancer Cell Line | Gene: BRD4 (bromodomain containing 4)
Type: protein-coding
Summary: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a ... |
Does Knockout of SLC8A2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | SLC8A2 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SLC8A2 (solute carrier family 8 member A2)
Type: protein-coding
Summary: Predicted to enable calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Predicted to be involved in several processes, includin... |
Does Knockout of MCCD1 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | MCCD1 | cell proliferation | Glioblastoma Cell Line | Gene: MCCD1 (mitochondrial coiled-coil domain 1)
Type: protein-coding
Summary: Predicted to be located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: mitochondrion
Pathways:
UniProt: P59942
Entrez ID: 401250 |
Does Knockout of PPA1 in Neuroblastoma Cell Line causally result in cell proliferation? | 1 | 824 | Knockout | PPA1 | cell proliferation | Neuroblastoma Cell Line | Gene: PPA1 (inorganic pyrophosphatase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the inorganic pyrophosphatase (PPase) family. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Studies o... |
Does Knockout of SAMD4B in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | SAMD4B | cell proliferation | Endometrial Cancer Cell Line | Gene: SAMD4B (sterile alpha motif domain containing 4B)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cerebellar neuron development. Located in cytosol. [provided by Allianc... |
Does Knockout of IL6ST in Hepatoma Cell Line causally result in response to virus? | 1 | 2,437 | Knockout | IL6ST | response to virus | Hepatoma Cell Line | Gene: IL6ST (interleukin 6 cytokine family signal transducer)
Type: protein-coding
Summary: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This ... |
Does Knockout of TGS1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | TGS1 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: TGS1 (trimethylguanosine synthase 1)
Type: protein-coding
Summary: Enables RNA trimethylguanosine synthase activity. Involved in 7-methylguanosine cap hypermethylation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: 7-methylguanosin... |
Does Knockout of FYB1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | FYB1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: FYB1 (FYN binding protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encod... |
Does Knockout of ARHGAP10 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | ARHGAP10 | cell proliferation | Medulloblastoma Cell Line | Gene: ARHGAP10 (Rho GTPase activating protein 10)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in cytoskeleton organization and negative regulation of apoptotic process. Predicted to be located in perinuclear region of cytoplasm and plasma membran... |
Does Knockout of ACTR1A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | ACTR1A | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: ACTR1A (actin related protein 1A)
Type: protein-coding
Summary: This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of... |
Does Knockout of IL5 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 787 | Knockout | IL5 | cell proliferation | Gastric Cancer Cell Line | Gene: IL5 (interleukin 5)
Type: protein-coding
Summary: This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased p... |
Does Knockout of TRIM49D1 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | TRIM49D1 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: TRIM49D1 (tripartite motif containing 49D1)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance... |
Does Knockout of NKD1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | NKD1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: NKD1 (NKD inhibitor of Wnt signaling pathway 1)
Type: protein-coding
Summary: In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[sup... |
Does Knockout of B3GNT5 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 0 | 1,397 | Knockout | B3GNT5 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: B3GNT5 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5)
Type: protein-coding
Summary: This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II membrane protein. It exhibits strong activity to transfer GlcNAc to glycolipid substrates... |
Does Knockout of MRAP in Prostate Cancer Cell Line causally result in cell proliferation? | 0 | 843 | Knockout | MRAP | cell proliferation | Prostate Cancer Cell Line | Gene: MRAP (melanocortin 2 receptor accessory protein)
Type: protein-coding
Summary: This gene encodes a melanocortin receptor-interacting protein. The encoded protein regulates trafficking and function of the melanocortin 2 receptor in the adrenal gland. The encoded protein can also modulate signaling ... |
Does Knockout of NPIPB5 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | NPIPB5 | cell proliferation | Monocytic Leukemia Cell Line | Gene: NPIPB5 (nuclear pore complex interacting protein family member B5)
Type: protein-coding
Summary: Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: A8MRT5
Entrez ID: 100132247 |
Does Knockout of MYO10 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | MYO10 | response to virus | Hepatoma Cell Line | Gene: MYO10 (myosin X)
Type: protein-coding
Summary: This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosi... |
Does Knockout of STIL in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | STIL | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: STIL (STIL centriolar assembly protein)
Type: protein-coding
Summary: This gene encodes a cytoplasmic protein implicated in regulation of the mitotic spindle checkpoint, a regulatory pathway that monitors chromosome segregation during cell division to ensure the proper distribution of chromosomes ... |
Does Knockout of GFRA2 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | GFRA2 | response to chemicals | Melanoma Cell Line | Gene: GFRA2 (GDNF family receptor alpha 2)
Type: protein-coding
Summary: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this... |
Does Knockout of SLC5A8 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | SLC5A8 | cell proliferation | Colorectal Cancer Cell Line | Gene: SLC5A8 (solute carrier family 5 member 8)
Type: protein-coding
Summary: SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]).... |
Does Knockout of TUBA3E in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | TUBA3E | cell proliferation | Breast Cancer Cell Line | Gene: TUBA3E (tubulin alpha 3e)
Type: protein-coding
Summary: Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is c... |
Does Knockout of KDM6B in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | KDM6B | cell proliferation | Cancer Cell Line | Gene: KDM6B (lysine demethylase 6B)
Type: protein-coding
Summary: The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chroma... |
Does Knockout of DHRS11 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | DHRS11 | cell proliferation | Glioblastoma Cell Line | Gene: DHRS11 (dehydrogenase/reductase 11)
Type: protein-coding
Summary: Enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; and 3-keto sterol reductase activity. Involved in steroid biosynthetic process. Predicted to be located in extracellular region. ... |
Does Knockout of SYT11 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | SYT11 | response to chemicals | Glioblastoma Cell Line | Gene: SYT11 (synaptotagmin 11)
Type: protein-coding
Summary: This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded ... |
Does Knockout of SENP5 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | SENP5 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: SENP5 (SUMO specific peptidase 5)
Type: protein-coding
Summary: The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsib... |
Does Knockout of SNU13 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | SNU13 | cell proliferation | Glioblastoma Cell Line | Gene: SNU13 (small nuclear ribonucleoprotein 13)
Type: protein-coding
Summary: Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. ... |
Does Knockout of ATF7 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | ATF7 | cell proliferation | Colorectal Cancer Cell Line | Gene: ATF7 (activating transcription factor 7)
Type: protein-coding
Summary: Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negat... |
Does Knockout of MTFMT in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | MTFMT | cell proliferation | T-lymphoma cell line | Gene: MTFMT (mitochondrial methionyl-tRNA formyltransferase)
Type: protein-coding
Summary: The protein encoded by this nuclear gene localizes to the mitochondrion, where it catalyzes the formylation of methionyl-tRNA. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: conversion of methionyl-tR... |
Does Knockout of ERGIC3 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 1 | 1,480 | Knockout | ERGIC3 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: ERGIC3 (ERGIC and golgi 3)
Type: protein-coding
Summary: Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of CDK2AP1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | CDK2AP1 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CDK2AP1 (cyclin dependent kinase 2 associated protein 1)
Type: protein-coding
Summary: The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis... |
Does Knockout of NDC80 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | NDC80 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: NDC80 (NDC80 kinetochore complex component)
Type: protein-coding
Summary: This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the compl... |
Does Knockout of ADAR in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | ADAR | cell proliferation | Ewing's Sarcoma Cell Line | Gene: ADAR (adenosine deaminase RNA specific)
Type: protein-coding
Summary: This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been assoc... |
Does Knockout of NOL8 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | NOL8 | cell proliferation | Gastric Cancer Cell Line | Gene: NOL8 (nucleolar protein 8)
Type: protein-coding
Summary: NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: protein localization to nucleolus, rRNA process... |
Does Knockout of DPYSL5 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | DPYSL5 | cell proliferation | Cancer Cell Line | Gene: DPYSL5 (dihydropyrimidinase like 5)
Type: protein-coding
Summary: This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had parane... |
Does Knockout of ZMAT2 in Hepatoma Cell Line causally result in response to virus? | 0 | 2,437 | Knockout | ZMAT2 | response to virus | Hepatoma Cell Line | Gene: ZMAT2 (zinc finger matrin-type 2)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and zinc ion binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of ETNK2 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,352 | Knockout | ETNK2 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: ETNK2 (ethanolamine kinase 2)
Type: protein-coding
Summary: The protein encoded by this gene is a member of choline/ethanolamine kinase family which catalyzes the first step of phosphatidylethanolamine (PtdEtn) biosynthesis via the cytidine diphosphate (CDP) ethanolamine pathway. Alternative splic... |
Does Knockout of USP17L25 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | USP17L25 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: USP17L25 (ubiquitin specific peptidase 17 like family member 25)
Type: protein-coding
Summary: Enables RNA binding activity; hyaluronic acid binding activity; and thiol-dependent deubiquitinase. Involved in positive regulation of epithelial cell apoptotic process and protein deubiquitination invol... |
Does Knockout of PSMA1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 1 | 1,996 | Knockout | PSMA1 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: PSMA1 (proteasome 20S subunit alpha 1)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 ri... |
Does Knockout of GPR157 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | GPR157 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: GPR157 (G protein-coupled receptor 157)
Type: protein-coding
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway and radia... |
Does Knockout of MSMP in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | MSMP | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: MSMP (microseminoprotein, prostate associated)
Type: protein-coding
Summary: This gene encodes a member of the beta-microseminoprotein family. Members of this protein family contain ten conserved cysteine residues that form intra-molecular disulfide bonds. The encoded protein may play a role in pr... |
Does Knockout of PFN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | PFN1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PFN1 (profilin 1)
Type: protein-coding
Summary: This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associa... |
Does Knockout of RPL26 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | RPL26 | cell proliferation | Bladder Carcinoma | Gene: RPL26 (ribosomal protein L26)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of WARS2 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | WARS2 | cell proliferation | Cancer Cell Line | Gene: WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial)
Type: protein-coding
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetas... |
Does Knockout of RPF1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | RPF1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RPF1 (ribosome production factor 1 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation ... |
Does Knockout of KLHL12 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | KLHL12 | cell proliferation | Hepatoma Cell Line | Gene: KLHL12 (kelch like family member 12)
Type: protein-coding
Summary: This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This... |
Does Knockout of SBSPON in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | SBSPON | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: SBSPON (somatomedin B and thrombospondin type 1 domain containing)
Type: protein-coding
Summary: Predicted to be an extracellular matrix structural constituent. Colocalizes with collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: C... |
Does Knockout of ZBTB8OS in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | ZBTB8OS | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: ZBTB8OS (zinc finger and BTB domain containing 8 opposite strand)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Involved in tRNA splicing, via endonucleolytic cleavage and ligation. Part of tRNA-splicing ligase complex. [provided by Alliance of Genome Resources, Apr... |
Does Knockout of QSER1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | QSER1 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: QSER1 (glutamine and serine rich 1)
Type: protein-coding
Summary: Predicted to be located in chromosome. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: Q2KHR3
Entrez ID: 79832 |
Does Knockout of EIF2B3 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | EIF2B3 | cell proliferation | Cancer Cell Line | Gene: EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma)
Type: protein-coding
Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function ... |
Does Knockout of RPS9 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | RPS9 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: RPS9 (ribosomal protein S9)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of MFAP1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | MFAP1 | cell proliferation | Endometrial Cancer Cell Line | Gene: MFAP1 (microfibril associated protein 1)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Located in centrosome; microfibril; and nucleoplasm. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of ICOSLG in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | ICOSLG | cell proliferation | Renal Cancer Cell Line | Gene: ICOSLG (inducible T cell costimulator ligand)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be involved in T cell receptor signaling pathway and positive regulation of interleukin-4 production. Located in cytoplasmic ribonucleoprotein granule and plasma mem... |
Does Activation of RRM2 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | RRM2 | response to virus | Hepatoma Cell Line | Gene: RRM2 (ribonucleotide reductase regulatory subunit M2)
Type: protein-coding
Summary: This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regula... |
Does Knockout of NUP88 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | NUP88 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: NUP88 (nucleoporin 88)
Type: protein-coding
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the ma... |
Does Knockout of HOXD13 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | HOXD13 | cell proliferation | Medulloblastoma Cell Line | Gene: HOXD13 (homeobox D13)
Type: protein-coding
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gen... |
Does Knockout of RHOA in T-lymphoma cell line causally result in cell proliferation? | 1 | 478 | Knockout | RHOA | cell proliferation | T-lymphoma cell line | Gene: RHOA (ras homolog family member A)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization... |
Does Knockout of THG1L in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | THG1L | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: THG1L (tRNA-histidine guanylyltransferase 1 like)
Type: protein-coding
Summary: The protein encoded by this gene is a mitochondrial protein that is induced by high levels of glucose and is associated with diabetic nephropathy. The encoded protein appears to increase mitochondrial biogenesis, which... |
Does Knockout of PDE4DIP in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | PDE4DIP | cell proliferation | Renal Cancer Cell Line | Gene: PDE4DIP (phosphodiesterase 4D interacting protein)
Type: protein-coding
Summary: The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia.... |
Does Knockout of CSMD1 in Renal Cancer Cell Line causally result in cell proliferation? | 0 | 319 | Knockout | CSMD1 | cell proliferation | Renal Cancer Cell Line | Gene: CSMD1 (CUB and Sushi multiple domains 1)
Type: protein-coding
Summary: Predicted to act upstream of or within several processes, including learning or memory; mammary gland branching involved in pregnancy; and reproductive structure development. Predicted to be integral component of membrane. [pro... |
Does Activation of SMARCAD1 in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | SMARCAD1 | protein/peptide accumulation | T cell | Gene: SMARCAD1 (SNF2 related chromatin remodeling ATPase with DExD box 1)
Type: protein-coding
Summary: This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic pattern... |
Does Knockout of RAB33B in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | RAB33B | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: RAB33B (RAB33B, member RAS oncogene family)
Type: protein-coding
Summary: This gene encodes a small GTP-binding protein of the Rab GTPase family, whose members function in vesicle transport during protein secretion and endocytosis. Rab GTPases are active, membrane-associated proteins that recruit ... |
Does Knockout of TRNT1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,032 | Knockout | TRNT1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: TRNT1 (tRNA nucleotidyl transferase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a CCA-adding enzyme which belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. This essential enzyme functions by catalyzing the addition of the conserved nucleotide triplet CC... |
Does Knockout of DNMT3A in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | DNMT3A | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: DNMT3A (DNA methyltransferase 3 alpha)
Type: protein-coding
Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. T... |
Does Knockout of OPA3 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | OPA3 | cell proliferation | Colonic Cancer Cell Line | Gene: OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3)
Type: protein-coding
Summary: The mouse ortholog of this protein co-purifies with the mitochondrial inner membrane. Mutations in this gene have been shown to result in 3-methylglutaconic aciduria type III and autosomal dominant op... |
Does Knockout of ADRA1D in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | ADRA1D | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: ADRA1D (adrenoceptor alpha 1D)
Type: protein-coding
Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B a... |
Does Knockout of EXOSC10 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 80 | Knockout | EXOSC10 | cell proliferation | Monocytic Leukemia Cell Line | Gene: EXOSC10 (exosome component 10)
Type: protein-coding
Summary: Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via telomerase. Located in cytosol; nuclear lumen; and trans... |
Does Knockout of MICU2 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | MICU2 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: MICU2 (mitochondrial calcium uptake 2)
Type: protein-coding
Summary: Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermem... |
Does Knockout of PSMD4 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | PSMD4 | cell proliferation | Endometrial Cancer Cell Line | Gene: PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical s... |
Does Knockout of HNRNPL in Prostate Cancer Cell Line causally result in cell proliferation? | 1 | 843 | Knockout | HNRNPL | cell proliferation | Prostate Cancer Cell Line | Gene: HNRNPL (heterogeneous nuclear ribonucleoprotein L)
Type: protein-coding
Summary: Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotei... |
Does Knockout of WNT7B in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,119 | Knockout | WNT7B | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: WNT7B (Wnt family member 7B)
Type: protein-coding
Summary: This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regula... |
Does Knockout of LMX1A in Lung Cancer Cell Line causally result in response to virus? | 0 | 1,433 | Knockout | LMX1A | response to virus | Lung Cancer Cell Line | Gene: LMX1A (LIM homeobox transcription factor 1 alpha)
Type: protein-coding
Summary: This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the devel... |
Does Knockout of ARSJ in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | ARSJ | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: ARSJ (arylsulfatase family member J)
Type: protein-coding
Summary: Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macr... |
Does Knockout of USP19 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | USP19 | cell proliferation | Endometrial Cancer Cell Line | Gene: USP19 (ubiquitin specific peptidase 19)
Type: protein-coding
Summary: Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinat... |
Does Knockout of RICTOR in Cancer Cell Line causally result in cell proliferation? | 0 | 193 | Knockout | RICTOR | cell proliferation | Cancer Cell Line | Gene: RICTOR (RPTOR independent companion of MTOR complex 2)
Type: protein-coding
Summary: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by O... |
Does Knockout of GLIPR1L1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 0 | 699 | Knockout | GLIPR1L1 | cell proliferation | Ovarian Cancer Cell Line | Gene: GLIPR1L1 (GLIPR1 like 1)
Type: protein-coding
Summary: Predicted to be involved in single fertilization. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in sperm connecting piece. Predicted to be active in extracellular space. [provided b... |
Does Knockout of RTF1 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | RTF1 | cell proliferation | Medulloblastoma Cell Line | Gene: RTF1 (RTF1 homolog, Paf1/RNA polymerase II complex component)
Type: protein-coding
Summary: This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stra... |
Does Knockout of NADK2 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | NADK2 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: NADK2 (NAD kinase 2, mitochondrial)
Type: protein-coding
Summary: This gene encodes a mitochondrial kinase that catalyzes the phosphorylation of NAD to yield NADP. Mutations in this gene result in 2,4-dienoyl-CoA reductase deficiency. Alternative splicing results in multiple transcript variants. [... |
Does Knockout of OR4S2 in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | OR4S2 | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: OR4S2 (olfactory receptor family 4 subfamily S member 2)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protei... |
Does Knockout of PPIE in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | PPIE | cell proliferation | Mammary Gland Tumor Cell Line | Gene: PPIE (peptidylprolyl isomerase E)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of prote... |
Does Knockout of TUBGCP6 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | TUBGCP6 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: TUBGCP6 (tubulin gamma complex component 6)
Type: protein-coding
Summary: The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic microtubule organization... |
Does Knockout of MRE11 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | MRE11 | cell proliferation | Medulloblastoma Cell Line | Gene: MRE11 (MRE11 double strand break repair nuclease)
Type: protein-coding
Summary: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activ... |
Does Knockout of TMED6 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | TMED6 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: TMED6 (transmembrane p24 trafficking protein 6)
Type: protein-coding
Summary: Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be i... |
Does Knockout of NHP2 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | NHP2 | cell proliferation | Colonic Cancer Cell Line | Gene: NHP2 (NHP2 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA ... |
Does Knockout of RBX1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | RBX1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: RBX1 (ring-box 1)
Type: protein-coding
Summary: This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnove... |
Does Knockout of TANK in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | TANK | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: TANK (TRAF family member associated NFKB activator)
Type: protein-coding
Summary: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is ... |
Does Activation of TAB3 in T cell causally result in protein/peptide accumulation? | 1 | 2,426 | Activation | TAB3 | protein/peptide accumulation | T cell | Gene: TAB3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3)
Type: protein-coding
Summary: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the prot... |
Does Knockout of ZCCHC13 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 1,246 | Knockout | ZCCHC13 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ZCCHC13 (zinc finger CCHC-type containing 13)
Type: protein-coding
Summary: This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 3. However, the CDS of this intronless gene remains relatively intact, it is conserved in other mammalian species, i... |
Does Knockout of KRTCAP2 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | KRTCAP2 | cell proliferation | Glioblastoma Cell Line | Gene: KRTCAP2 (keratinocyte associated protein 2)
Type: protein-coding
Summary: Enables enzyme activator activity. Involved in protein N-linked glycosylation via arginine. Is active in oligosaccharyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: pro... |
Does Knockout of LYSMD2 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | LYSMD2 | response to chemicals | Melanoma Cell Line | Gene: LYSMD2 (LysM domain containing 2)
Type: protein-coding
Summary: LysM domain containing 2
Gene Ontology:
Pathways:
UniProt: Q8IV50
Entrez ID: 256586 |
Does Knockout of SYMPK in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | SYMPK | cell proliferation | Mammary Gland Tumor Cell Line | Gene: SYMPK (symplekin scaffold protein)
Type: protein-coding
Summary: This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought t... |
Does Knockout of WEE2 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | WEE2 | cell proliferation | Multiple Myeloma Cell Line | Gene: WEE2 (WEE2 oocyte meiosis inhibiting kinase)
Type: protein-coding
Summary: Predicted to enable protein tyrosine kinase activity. Predicted to be involved in several processes, including female pronucleus assembly; negative regulation of oocyte maturation; and regulation of meiosis I. Located in cy... |
Does Knockout of NOP10 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | NOP10 | cell proliferation | Colonic Cancer Cell Line | Gene: NOP10 (NOP10 ribonucleoprotein)
Type: protein-coding
Summary: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/AC... |
Does Knockout of PTBP1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | PTBP1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: PTBP1 (polypyrimidine tract binding protein 1)
Type: protein-coding
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins a... |
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