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Does Knockout of NUP98 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
NUP98
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: NUP98 (nucleoporin 98 and 96 precursor)
Type: protein-coding
Summary: Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: RNA export from nucleus, mRNA transport, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, positive regulation of DNA-templated transcription, positive regulation of mRNA splicing, via spliceosome, post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery, protein import into nucleus, protein transport, proteolysis, telomere tethering at nuclear periphery; MF: RNA binding, hydrolase activity, mRNA binding, molecular condensate scaffold activity, nuclear localization sequence binding, peptidase activity, peptide binding, promoter-specific chromatin binding, protein binding, serine-type peptidase activity, structural constituent of nuclear pore, transcription coactivator activity; CC: cytosol, kinetochore, membrane, nuclear body, nuclear envelope, nuclear inclusion body, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore cytoplasmic filaments, nuclear pore nuclear basket, nuclear pore outer ring, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Influenza A - Homo sapiens (human), RNA transport - Homo sapiens (human), SARS-CoV-2 innate immunity evasion and cell-specific immune response
UniProt: P52948
Entrez ID: 4928
|
Does Knockout of SMAD4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,032
|
Knockout
|
SMAD4
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SMAD4 (SMAD family member 4)
Type: protein-coding
Summary: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasing blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, May 2022].
Gene Ontology: BP: BMP signaling pathway, DNA-templated transcription, ERK1 and ERK2 cascade, SMAD protein signal transduction, activin receptor signaling pathway, adrenal gland development, anatomical structure morphogenesis, anterior/posterior pattern specification, atrioventricular canal development, atrioventricular valve formation, axon guidance, brainstem development, branching involved in ureteric bud morphogenesis, cardiac conduction system development, cardiac muscle hypertrophy in response to stress, cardiac septum development, cell differentiation, cell population proliferation, cellular response to BMP stimulus, cellular response to glucose stimulus, cellular response to growth factor stimulus, cellular response to transforming growth factor beta stimulus, developmental growth, embryonic digit morphogenesis, endocardial cell differentiation, endoderm development, endothelial cell activation, epithelial cell migration, epithelial to mesenchymal transition, epithelial to mesenchymal transition involved in endocardial cushion formation, extrinsic apoptotic signaling pathway, female gonad development, female gonad morphogenesis, formation of anatomical boundary, gastrulation, gastrulation with mouth forming second, in utero embryonic development, interleukin-6-mediated signaling pathway, intracellular iron ion homeostasis, intracellular signal transduction, kidney development, left ventricular cardiac muscle tissue morphogenesis, male gonad development, mesendoderm development, mesoderm development, metanephric mesenchyme morphogenesis, negative regulation of DNA-templated transcription, negative regulation of ERK1 and ERK2 cascade, negative regulation of canonical Wnt signaling pathway, negative regulation of cardiac muscle hypertrophy, negative regulation of cardiac myofibril assembly, negative regulation of cell growth, negative regulation of cell population proliferation, negative regulation of protein catabolic process, negative regulation of transcription by RNA polymerase II, nephrogenic mesenchyme morphogenesis, neural crest cell differentiation, neuron fate commitment, neuron fate specification, osteoblast differentiation, outflow tract septum morphogenesis, ovarian follicle development, positive regulation of DNA-templated transcription, positive regulation of SMAD protein signal transduction, positive regulation of cardiac muscle cell apoptotic process, positive regulation of cell proliferation involved in heart valve morphogenesis, positive regulation of epithelial to mesenchymal transition, positive regulation of extracellular matrix assembly, positive regulation of follicle-stimulating hormone secretion, positive regulation of gene expression, positive regulation of luteinizing hormone secretion, positive regulation of miRNA transcription, positive regulation of transcription by RNA polymerase II, positive regulation of transforming growth factor beta receptor signaling pathway, regulation of DNA-templated transcription, regulation of cell population proliferation, regulation of gene expression, regulation of hair follicle development, regulation of primary metabolic process, regulation of transcription by RNA polymerase II, regulation of transforming growth factor beta2 production, response to hypoxia, response to transforming growth factor beta, sebaceous gland development, secondary palate development, seminiferous tubule development, single fertilization, somite rostral/caudal axis specification, spermatogenesis, tissue morphogenesis, transcription by RNA polymerase II, transforming growth factor beta receptor signaling pathway, transforming growth factor beta receptor superfamily signaling pathway, uterus development, ventricular septum morphogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, I-SMAD binding, R-SMAD binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, SMAD binding, chromatin binding, collagen binding, filamin binding, identical protein binding, metal ion binding, protein binding, protein homodimerization activity, protein-containing complex binding, sequence-specific DNA binding, sulfate binding, transcription cis-regulatory region binding, transcription coactivator binding, transcription corepressor binding; CC: RNA polymerase II transcription regulator complex, SMAD protein complex, activin responsive factor complex, centrosome, chromatin, ciliary basal body, cytoplasm, cytosol, heteromeric SMAD protein complex, nucleoplasm, nucleus, protein-containing complex, transcription regulator complex
Pathways: AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human), ALK1 signaling events, ALK2 signaling events, Adherens junction - Homo sapiens (human), Adipogenesis, Androgen receptor signaling pathway, Apelin signaling pathway - Homo sapiens (human), BMP Signaling Pathway in Eyelid Development, BMP Signalling Pathway, BMP receptor signaling, Bone morphogenic protein (BMP) signaling and regulation, Canonical and non-canonical TGF-B signaling, Cardiogenesis, Cell cycle, Cell cycle - Homo sapiens (human), Chromosomal and microsatellite instability in colorectal cancer, Chronic myeloid leukemia - Homo sapiens (human), Colorectal cancer - Homo sapiens (human), DNA damage response (only ATM dependent), Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downregulation of SMAD2/3:SMAD4 transcriptional activity, ESC Pluripotency Pathways, Ectoderm Differentiation, Endoderm differentiation, Envelope proteins and their potential roles in EDMD physiopathology, Epithelial to mesenchymal transition in colorectal cancer, Extracellular vesicle-mediated signaling in recipient cells, FOXO-mediated transcription, FOXO-mediated transcription of cell cycle genes, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes, Formation of definitive endoderm, FoxO signaling pathway - Homo sapiens (human), Gastric cancer - Homo sapiens (human), Gastrulation, Gene expression (Transcription), Generic Transcription Pathway, Germ layer formation at gastrulation, HIF-1-alpha transcription factor network, Head and Neck Squamous Cell Carcinoma, Heart Development, Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C and Hepatocellular Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), Hypothesized Pathways in Pathogenesis of Cardiovascular Disease, Infectious disease, LKB1 signaling events, Loss of Function of SMAD2/3 in Cancer, Loss of Function of SMAD4 in Cancer, Mesodermal commitment pathway, Metabolism of proteins, Osteoblast differentiation, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Post-translational protein modification, RNA Polymerase II Transcription, RUNX2 regulates bone development, RUNX3 regulates BCL2L11 (BIM) transcription, RUNX3 regulates CDKN1A transcription, Regucalcin in proximal tubule epithelial kidney cells, Regulation of cytoplasmic and nuclear SMAD2/3 signaling, Regulation of nuclear SMAD2/3 signaling, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 targets host intracellular signalling and regulatory pathways, SARS-CoV-1-host interactions, SMAD2/3 MH2 Domain Mutants in Cancer, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, SMAD4 MH2 Domain Mutants in Cancer, Senescence and Autophagy in Cancer, Signal Transduction, Signaling by Activin, Signaling by BMP, Signaling by NODAL, Signaling by TGF-beta Receptor Complex, Signaling by TGF-beta Receptor Complex in Cancer, Signaling by TGFB family members, Signaling by TGFBR3, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition, TGF-beta Receptor Signaling, TGF-beta Signaling Pathway, TGF-beta receptor signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in skeletal dysplasias, TGF-beta signaling pathway - Homo sapiens (human), TGFBR3 expression, TGF_beta_Receptor, Th17 cell differentiation - Homo sapiens (human), Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Transcriptional regulation of brown and beige adipocyte differentiation, Transcriptional regulation of brown and beige adipocyte differentiation by EBF2, Transcriptional regulation of pluripotent stem cells, Ub-specific processing proteases, Validated nuclear estrogen receptor alpha network, Validated targets of C-MYC transcriptional activation, Validated targets of C-MYC transcriptional repression, Viral Infection Pathways, Vitamin D in inflammatory diseases, Wnt signaling pathway - Homo sapiens (human), alk in cardiac myocytes, cell cycle: g1/s check point, ctcf: first multivalent nuclear factor, nfkb activation by nontypeable hemophilus influenzae, tgf beta signaling pathway, wnt signaling pathway
UniProt: Q13485
Entrez ID: 4089
|
Does Knockout of PSMD1 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
PSMD1
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: PSMD1 (proteasome 26S subunit, non-ATPase 1)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. There is evidence that this proteasome and its subunits interact with viral proteins, including those of coronaviruses. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2020].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, regulation of protein catabolic process; MF: enzyme regulator activity, protein binding, ubiquitin protein ligase binding; CC: azurophil granule lumen, cytosol, extracellular region, membrane, nucleoplasm, nucleus, proteasome accessory complex, proteasome complex, proteasome regulatory particle, proteasome regulatory particle, base subcomplex, proteasome storage granule
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), Huntington disease - Homo sapiens (human), Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), TNFalpha
UniProt: Q99460
Entrez ID: 5707
|
Does Knockout of PRIMPOL in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
PRIMPOL
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: PRIMPOL (primase and DNA directed polymerase)
Type: protein-coding
Summary: This gene encodes a DNA primase-polymerase that belongs to a superfamily of archaeao-eukaryotic primases. Members of this family have primase activity, catalyzing the synthesis of short RNA primers that serve as starting points for DNA synthesis, as well as DNA polymerase activity. The encoded protein facilitates DNA damage tolerance by mediating uninterrupted fork progression after UV irradiation and reinitiating DNA synthesis. An allelic variant in this gene is associated with myopia 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, synthesis of primer, DNA-templated DNA replication, R-loop processing, error-prone translesion synthesis, mitochondrial DNA repair, mitochondrial DNA replication, replication fork processing, response to UV, translesion synthesis; MF: DNA polymerase activity, DNA-directed DNA polymerase activity, DNA-directed RNA polymerase activity, chromatin binding, manganese ion binding, metal ion binding, nucleotidyltransferase activity, protein binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, chromosome, mitochondrial matrix, mitochondrion, nucleus, replication fork
Pathways:
UniProt: Q96LW4
Entrez ID: 201973
|
Does Knockout of SLC4A11 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
SLC4A11
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SLC4A11 (solute carrier family 4 member 11)
Type: protein-coding
Summary: This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: bicarbonate transport, borate transmembrane transport, borate transport, cellular hypotonic response, cellular response to oxidative stress, fluid transport, intracellular monoatomic cation homeostasis, monoatomic anion transport, monoatomic ion homeostasis, monoatomic ion transport, proton transmembrane transport, regulation of mesenchymal stem cell differentiation, regulation of mitochondrial membrane potential, sodium ion transmembrane transport, sodium ion transport, transmembrane transport, water transport; MF: active borate transmembrane transporter activity, antiporter activity, bicarbonate transmembrane transporter activity, protein dimerization activity, proton channel activity, proton transmembrane transporter activity, sodium channel activity, solute:inorganic anion antiporter activity, symporter activity, transmembrane transporter activity, water transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, plasma membrane, vesicle membrane
Pathways:
UniProt: Q8NBS3
Entrez ID: 83959
|
Does Knockout of YIF1A in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
YIF1A
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: YIF1A (Yip1 interacting factor homolog A, membrane trafficking protein)
Type: protein-coding
Summary: Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in Golgi apparatus and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle-mediated transport; CC: COPII-coated ER to Golgi transport vesicle, Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane
Pathways: Cellular responses to stimuli, Cellular responses to stress, IRE1alpha activates chaperones, Unfolded Protein Response (UPR), XBP1(S) activates chaperone genes
UniProt: O95070
Entrez ID: 10897
|
Does Knockout of RFX2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 220
|
Knockout
|
RFX2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: RFX2 (regulatory factor X2)
Type: protein-coding
Summary: This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: acrosome assembly, cell differentiation, cell projection organization, cellular response to leukemia inhibitory factor, cilium assembly, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermatid development, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, cytoplasm, nucleus
Pathways:
UniProt: P48378
Entrez ID: 5990
|
Does Knockout of POLR2H in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
POLR2H
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: POLR2H (RNA polymerase II, I and III subunit H)
Type: protein-coding
Summary: The three eukaryotic RNA polymerases are complex multisubunit enzymes that play a central role in the transcription of nuclear genes. This gene encodes an essential and highly conserved subunit of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: DNA-templated transcription, transcription by RNA polymerase II; MF: DNA binding, DNA-directed RNA polymerase activity, single-stranded DNA binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, RNA polymerase II, core complex, RNA polymerase III complex, cytosol, nucleolus, nucleoplasm, nucleus, protein-DNA complex
Pathways: Abortive elongation of HIV-1 transcript in the absence of Tat, Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, B-WICH complex positively regulates rRNA expression, Cell Cycle, Chromosome Maintenance, Cytosolic DNA-sensing pathway, Cytosolic DNA-sensing pathway - Homo sapiens (human), Cytosolic sensors of pathogen-associated DNA , DNA Repair, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dual incision in TC-NER, ESR-mediated signaling, Epigenetic regulation of gene expression, Estrogen-dependent gene expression, Eukaryotic Transcription Initiation, FGFR2 alternative splicing, FGFR2 mutant receptor activation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene Silencing by RNA, Gene expression (Transcription), Generic Transcription Pathway, HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, HIV elongation arrest and recovery, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inhibition of DNA recombination at telomere, Innate Immune System, Late Phase of HIV Life Cycle, Metabolism of RNA, MicroRNA (miRNA) biogenesis, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, PIWI-interacting RNA (piRNA) biogenesis, Pausing and recovery of HIV elongation, Pausing and recovery of Tat-mediated HIV elongation, Positive epigenetic regulation of rRNA expression, Processing of Capped Intron-Containing Pre-mRNA, Pyrimidine metabolism, RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA Polymerase III Abortive And Retractive Initiation, RNA Polymerase III Chain Elongation, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 1 Promoter, RNA Polymerase III Transcription Initiation From Type 2 Promoter, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA Polymerase III Transcription Termination, RNA polymerase - Homo sapiens (human), RNA polymerase II transcribes snRNA genes, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR2, Signaling by FGFR2 IIIa TM, Signaling by FGFR2 in disease, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, TNFalpha, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated HIV elongation arrest and recovery, Tat-mediated elongation of the HIV-1 transcript, Telomere Maintenance, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional regulation by small RNAs, Viral Infection Pathways, Viral Messenger RNA Synthesis, mRNA Capping, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P52434
Entrez ID: 5437
|
Does Knockout of PMAIP1 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
PMAIP1
|
cell proliferation
|
Cancer Cell Line
|
Gene: PMAIP1 (phorbol-12-myristate-13-acetate-induced protein 1)
Type: protein-coding
Summary: This gene belongs to a pro-apoptotic subfamily within the BCL-2 protein family, referred to as the BCL-2 homology domain 3 (BH3)-only subfamily, which determine whether a cell commits to apoptosis. In response to death-inducing stimuli, BH3-only members inhibit the anti-apoptotic BCL-2 family members, which under steady-state conditions keep the multi-BH domain proteins BAX and BAK, in an inactive state. [provided by RefSeq, Aug 2020].
Gene Ontology: BP: DNA damage response, T cell homeostasis, apoptotic process, cellular response to glucose starvation, cellular response to hypoxia, defense response to virus, intrinsic apoptotic signaling pathway, intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of mitochondrial membrane potential, positive regulation of DNA damage response, signal transduction by p53 class mediator, positive regulation of apoptotic process, positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, positive regulation of extrinsic apoptotic signaling pathway via death domain receptors, positive regulation of glucose metabolic process, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of release of cytochrome c from mitochondria, proteasomal protein catabolic process, reactive oxygen species metabolic process, regulation of mitochondrial membrane permeability, release of cytochrome c from mitochondria, response to dsRNA; CC: Bcl-2 family protein complex, cytosol, mitochondrial outer membrane, mitochondrion, nucleus
Pathways: Activation of BH3-only proteins, Activation of NOXA and translocation to mitochondria, Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis - multiple species - Homo sapiens (human), Apoptosis Modulation and Signaling, BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, Chromosomal and microsatellite instability in colorectal cancer, Colorectal cancer - Homo sapiens (human), DNA damage response, DNA damage response (only ATM dependent), Direct p53 effectors, Gene expression (Transcription), Generic Transcription Pathway, H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity, Intrinsic Pathway for Apoptosis, Pathways in cancer - Homo sapiens (human), Photodynamic therapy-induced HIF-1 survival signaling, Programmed Cell Death, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Death Genes, TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, TP53 network, Transcriptional Regulation by TP53, Unfolded protein response, Validated targets of C-MYC transcriptional activation, Validated transcriptional targets of TAp63 isoforms, Viral carcinogenesis - Homo sapiens (human), miRNA regulation of DNA damage response, miRNA regulation of p53 pathway in prostate cancer, p53 signaling pathway - Homo sapiens (human), p53 transcriptional gene network
UniProt: Q13794
Entrez ID: 5366
|
Does Knockout of MTG2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
MTG2
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: MTG2 (mitochondrial ribosome associated GTPase 2)
Type: protein-coding
Summary: Small G proteins, such as GTPBP5, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: mitochondrial large ribosomal subunit assembly, regulation of mitochondrial translation, regulation of respiratory system process, regulation of translation, ribosome biogenesis; MF: GTP binding, GTPase activity, magnesium ion binding, metal ion binding, nucleotide binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial ribosome, mitochondrion
Pathways:
UniProt: Q9H4K7
Entrez ID: 26164
|
Does Knockout of SLC30A7 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
SLC30A7
|
cell proliferation
|
T-lymphoma cell line
|
Gene: SLC30A7 (solute carrier family 30 member 7)
Type: protein-coding
Summary: Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: intracellular zinc ion homeostasis, monoatomic cation transport, monoatomic ion transport, transmembrane transport, zinc ion import into Golgi lumen, zinc ion transmembrane transport, zinc ion transport; MF: identical protein binding, monoatomic cation transmembrane transporter activity, zinc ion transmembrane transporter activity; CC: Golgi apparatus, Golgi cis cisterna membrane, Golgi membrane, cytoplasm, cytoplasmic vesicle, membrane, mitochondrion, perinuclear region of cytoplasm, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, vesicle
Pathways: Zinc homeostasis
UniProt: Q8NEW0
Entrez ID: 148867
|
Does Knockout of CARM1 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
CARM1
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: CARM1 (coactivator associated arginine methyltransferase 1)
Type: protein-coding
Summary: This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated proteins and is involved in regulation of gene expression. The enzyme may act in association with other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: apoptotic process, chromatin organization, chromatin remodeling, methylation, negative regulation of dendrite development, positive regulation of cell population proliferation, positive regulation of epithelial cell apoptotic process, positive regulation of fat cell differentiation, positive regulation of transcription by RNA polymerase I, regulation of DNA-templated transcription, regulation of intracellular estrogen receptor signaling pathway, replication fork reversal, response to cAMP; MF: DNA-binding transcription factor binding, beta-catenin binding, histone H3R17 methyltransferase activity, histone H3R2 methyltransferase activity, histone arginine N-methyltransferase activity, histone methyltransferase activity, methyltransferase activity, protein binding, protein methyltransferase activity, protein-arginine N-methyltransferase activity, protein-arginine omega-N asymmetric methyltransferase activity, transcription cis-regulatory region binding, transcription coactivator activity, transferase activity; CC: chromosome, cytoplasm, cytosol, nuclear replication fork, nucleoplasm, nucleus
Pathways: Activation of gene expression by SREBF (SREBP), Adipogenesis, Androgen receptor signaling pathway, BMAL1:CLOCK,NPAS2 activates circadian expression, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Chromatin modifying enzymes, Chromatin organization, Circadian clock, Coregulation of Androgen receptor activity, Cytoprotection by HMOX1, Developmental Biology, Direct p53 effectors, ESR-mediated signaling, Estrogen-dependent gene expression, Expression of BMAL (ARNTL), CLOCK, and NPAS2, Gene expression (Transcription), Generic Transcription Pathway, Heme signaling, Metabolism, Metabolism of lipids, Metabolism of steroids, Mitochondrial biogenesis, NO metabolism in cystic fibrosis, Organelle biogenesis and maintenance, PPARA activates gene expression, RMTs methylate histone arginines, RNA Polymerase II Transcription, RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression, Regulation of Androgen receptor activity, Regulation of cholesterol biosynthesis by SREBP (SREBF), Regulation of lipid metabolism by PPARalpha, Signal Transduction, Signaling by Nuclear Receptors, TP53 Regulates Transcription of Cell Cycle Genes, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Transcriptional Regulation by TP53, Transcriptional activation of mitochondrial biogenesis, Transcriptional regulation of white adipocyte differentiation, carm1 and regulation of the estrogen receptor, role of erbb2 in signal transduction and oncology, transcription regulation by methyltransferase of carm1
UniProt: Q86X55
Entrez ID: 10498
|
Does Knockout of OR13C5 in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 1
| 2,222
|
Knockout
|
OR13C5
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: OR13C5 (olfactory receptor family 13 subfamily C member 5)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, nucleoplasm, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGS8
Entrez ID: 138799
|
Does Knockout of TRIP6 in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
TRIP6
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: TRIP6 (thyroid hormone receptor interactor 6)
Type: protein-coding
Summary: This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, chordate embryonic development, focal adhesion assembly, positive regulation of cell migration, positive regulation of non-canonical NF-kappaB signal transduction, signal transduction; MF: RNA binding, interleukin-1 receptor binding, kinase binding, metal ion binding, nuclear thyroid hormone receptor binding, protein binding; CC: anchoring junction, cytoplasm, cytoskeleton, cytosol, focal adhesion, nucleus, plasma membrane, stress fiber
Pathways: AP-1 transcription factor network, EGFR1, LPA receptor mediated events, NOD-like receptor signaling pathway - Homo sapiens (human)
UniProt: Q15654
Entrez ID: 7205
|
Does Knockout of PRIM1 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
PRIM1
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: PRIM1 (DNA primase subunit 1)
Type: protein-coding
Summary: The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA replication initiation, DNA replication, synthesis of primer; MF: DNA-directed RNA polymerase activity, magnesium ion binding, metal ion binding, nucleotidyltransferase activity, protein binding, ribonucleotide binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, alpha DNA polymerase:primase complex, membrane, nucleoplasm
Pathways: Activation of the pre-replicative complex, Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA replication initiation, DNA strand elongation, Defective pyroptosis, Disease, Diseases of programmed cell death, E2F mediated regulation of DNA replication, Extension of Telomeres, G1 to S cell cycle control, G1/S Transition, Inhibition of replication initiation of damaged DNA by RB1/E2F1, Lagging Strand Synthesis, Leading Strand Synthesis, Mitotic G1 phase and G1/S transition, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processive synthesis on the lagging strand, Pyrimidine metabolism, Removal of the Flap Intermediate, Retinoblastoma gene in cancer, S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere C-strand synthesis initiation, Telomere Maintenance
UniProt: P49642
Entrez ID: 5557
|
Does Knockout of TICRR in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
TICRR
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: TICRR (TOPBP1 interacting checkpoint and replication regulator)
Type: protein-coding
Summary: Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, mitotic DNA replication checkpoint signaling, mitotic G2 DNA damage checkpoint signaling, regulation of DNA-templated DNA replication initiation, response to ionizing radiation; MF: chromatin binding, protein binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Cyclin A/B1/B2 associated events during G2/M transition, G2/M Transition, Mitotic G2-G2/M phases
UniProt: Q7Z2Z1
Entrez ID: 90381
|
Does Knockout of PRSS54 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
PRSS54
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: PRSS54 (serine protease 54)
Type: protein-coding
Summary: This gene encodes a putative serine-type endopeptidase containing the peptidase S1 domain. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: proteolysis; MF: serine-type endopeptidase activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q6PEW0
Entrez ID: 221191
|
Does Knockout of ARCN1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
ARCN1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: ARCN1 (archain 1 coat protein complex I subunit delta)
Type: protein-coding
Summary: This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or trafficking. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: Golgi localization, Golgi vesicle transport, adult locomotory behavior, cerebellar Purkinje cell layer maturation, endoplasmic reticulum to Golgi vesicle-mediated transport, establishment of localization in cell, intracellular protein transport, pigmentation, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: RNA binding, protein binding; CC: COPI vesicle coat, COPI-coated vesicle, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, transport vesicle
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, miR-517 relationship with ARCN1 and USP1
UniProt: P48444
Entrez ID: 372
|
Does Knockout of MYC in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
MYC
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: MYC (MYC proto-oncogene, bHLH transcription factor)
Type: protein-coding
Summary: This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: B cell apoptotic process, DNA damage response, ERK1 and ERK2 cascade, G1/S transition of mitotic cell cycle, MAPK cascade, NK T cell proliferation, Wnt signaling pathway, acinar cell proliferation, branching involved in ureteric bud morphogenesis, cell population proliferation, cellular response to UV, cellular response to hypoxia, cellular response to interferon-alpha, cellular response to xenobiotic stimulus, chromatin remodeling, chromosome organization, detection of mechanical stimulus involved in sensory perception of sound, fibroblast apoptotic process, intracellular iron ion homeostasis, intrinsic apoptotic signaling pathway in response to DNA damage, middle ear morphogenesis, myotube differentiation, negative regulation of apoptotic process, negative regulation of cell division, negative regulation of fibroblast proliferation, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of monocyte differentiation, negative regulation of stress-activated MAPK cascade, negative regulation of transcription by RNA polymerase II, negative regulation of transcription initiation by RNA polymerase II, pigmentation, positive regulation of B cell apoptotic process, positive regulation of DNA-templated transcription, positive regulation of acinar cell proliferation, positive regulation of apoptotic signaling pathway, positive regulation of cell population proliferation, positive regulation of epithelial cell proliferation, positive regulation of fibroblast proliferation, positive regulation of gene expression, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of mesenchymal cell proliferation, positive regulation of metanephric cap mesenchymal cell proliferation, positive regulation of miRNA transcription, positive regulation of telomere maintenance, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, proteasome-mediated ubiquitin-dependent protein catabolic process, protein processing, protein-DNA complex disassembly, rRNA metabolic process, regulation of DNA-templated transcription, regulation of apoptotic process, regulation of cell cycle process, regulation of gene expression, regulation of somatic stem cell population maintenance, regulation of telomere maintenance, regulation of transcription by RNA polymerase II, response to alkaloid, response to growth factor, response to radiation, response to xenobiotic stimulus, skeletal muscle cell differentiation, skeletal system morphogenesis, transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SCF ubiquitin ligase complex binding, cis-regulatory region sequence-specific DNA binding, core promoter sequence-specific DNA binding, identical protein binding, protein binding, protein dimerization activity, protein-containing complex binding, transcription coregulator binding, ubiquitin protein ligase binding; CC: Myc-Max complex, RNA polymerase II transcription repressor complex, axon, chromatin, chromosome, cytoplasm, euchromatin, nuclear body, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, protein-containing complex, spindle
Pathways: 3q29 copy number variation syndrome, AP-1 transcription factor network, Acute myeloid leukemia - Homo sapiens (human), Adaptive Immune System, Adherens junctions interactions, Apoptosis, Aryl Hydrocarbon Receptor Netpath, Association Between Physico-Chemical Features and Toxicity Associated Pathways, B Cell Receptor Signaling Pathway, Binding of TCF/LEF:CTNNB1 to target gene promoters, Bladder cancer, Bladder cancer - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, C-MYB transcription factor network, C-MYC pathway, CD40/CD40L signaling, Cell Cycle, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cellular senescence - Homo sapiens (human), Central carbon metabolism in cancer - Homo sapiens (human), Ceramide signaling pathway, Chromosomal and microsatellite instability in colorectal cancer, Chronic myeloid leukemia - Homo sapiens (human), Co-inhibition by PD-1, Colorectal cancer - Homo sapiens (human), Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Cyclin A:Cdk2-associated events at S phase entry, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, DNA damage response, DNA damage response (only ATM dependent), Deubiquitination, Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, E2F transcription factor network, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR1, ESR-mediated signaling, Ectoderm Differentiation, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Epstein-Barr virus infection - Homo sapiens (human), ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), Estrogen-dependent gene expression, FOXM1 transcription factor network, Formation of the beta-catenin:TCF transactivating complex, G0 and Early G1, G1 to S cell cycle control, G1/S Transition, Gastric Cancer Network 2, Gastric cancer - Homo sapiens (human), Gastrin signaling pathway, Gene expression (Transcription), Generic Transcription Pathway, Glutaminolysis and Cancer, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatitis C and Hepatocellular Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), IL-2 signaling pathway, IL-5 signaling pathway, IL-7 signaling pathway, IL2 signaling events mediated by PI3K, IL2 signaling events mediated by STAT5, IL2-mediated signaling events, IL6-mediated signaling events, Imatinib and Chronic Myeloid Leukemia, Immune System, Integrated Cancer Pathway, Integrated breast cancer pathway, Interleukin-4 and Interleukin-13 signaling, JAK-STAT signaling pathway - Homo sapiens (human), KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), LKB1 signaling events, LncRNA involvement in canonical Wnt signaling and colorectal cancer, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK pathway in congenital thyroid cancer, MAPK signaling pathway - Homo sapiens (human), MAPK6/MAPK4 signaling, Mammary gland development pathway - Embryonic development (Stage 1 of 4), Mammary gland development pathway - Involution (Stage 4 of 4), Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4), Mammary gland development pathway - Puberty (Stage 2 of 4), Metabolism of proteins, Metastatic brain tumor, MicroRNAs in cancer - Homo sapiens (human), Mitotic G1 phase and G1/S transition, NOTCH1 Intracellular Domain Regulates Transcription, Neural Crest Differentiation, Notch Signaling Pathway Netpath, Notch signaling pathway, Nuclear Receptors Meta-Pathway, Nuclear events mediated by NFE2L2, PDGFR-beta signaling pathway, PI3K-AKT-mTOR - VitD3 signaling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PPAR-alpha pathway, Pathways affected in adenoid cystic carcinoma, Pathways in cancer - Homo sapiens (human), Post-translational protein modification, Presenilin action in Notch and Wnt signaling, Prolactin Signaling Pathway, Proteoglycans in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, RNA Polymerase II Transcription, RUNX3 regulates WNT signaling, Regulation of CDH1 Expression and Function, Regulation of CDH1 mRNA translation by microRNAs, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of NFE2L2 gene expression, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Regulation of Telomerase, Regulation of apoptosis by parathyroid hormone-related protein, Regulation of nuclear SMAD2/3 signaling, Regulation of nuclear beta catenin signaling and target gene transcription, Retinoblastoma gene in cancer, S Phase, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, Salmonella infection - Homo sapiens (human), Signal Transduction, Signaling by ALK, Signaling by Interleukins, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Spinal Cord Injury, Structural Pathway of Interleukin 1 (IL-1), TCF dependent signaling in response to WNT, TFAP2 (AP-2) family regulates transcription of cell cycle factors, TGF-beta Signaling Pathway, TGF-beta signaling pathway - Homo sapiens (human), TGF_beta_Receptor, TP53 network, Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, Thyroid cancer - Homo sapiens (human), Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid stimulating hormone (TSH) signaling pathway, Transcription of E2F targets under negative control by DREAM complex, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional misregulation in cancer - Homo sapiens (human), Transcriptional regulation by RUNX3, Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors, Transcriptional regulation of granulopoiesis, Ub-specific processing proteases, Validated nuclear estrogen receptor alpha network, Validated targets of C-MYC transcriptional activation, Validated targets of C-MYC transcriptional repression, Vitamin D Receptor Pathway, Wnt Signaling Pathway, Wnt signaling, Wnt signaling pathway - Homo sapiens (human), Wnt signaling pathway and pluripotency, Wnt-beta-catenin signaling pathway in leukemia, cadmium induces dna synthesis and proliferation in macrophages, ctcf: first multivalent nuclear factor, erk1/erk2 mapk signaling pathway, inhibition of cellular proliferation by gleevec, let-7 inhibition of ES cell reprogramming, mapkinase signaling pathway, mechanism of gene regulation by peroxisome proliferators via ppara, miRNA regulation of DNA damage response, miRNAs involved in DNA damage response, ncRNAs involved in Wnt signaling in hepatocellular carcinoma, overview of telomerase protein component gene htert transcriptional regulation, p38 MAPK Signaling Pathway, p38 mapk signaling pathway, p73 transcription factor network, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, telomeres telomerase cellular aging and immortality, tumor suppressor arf inhibits ribosomal biogenesis, wnt signaling pathway
UniProt: P01106
Entrez ID: 4609
|
Does Knockout of TSPAN6 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
TSPAN6
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: TSPAN6 (tetraspanin 6)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: negative regulation of canonical NF-kappaB signal transduction, negative regulation of cytoplasmic pattern recognition receptor signaling pathway, positive regulation of canonical NF-kappaB signal transduction; CC: extracellular exosome, membrane, plasma membrane
Pathways:
UniProt: O43657
Entrez ID: 7105
|
Does Knockout of PRPF6 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
PRPF6
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PRPF6 (pre-mRNA processing factor 6)
Type: protein-coding
Summary: The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA localization, RNA processing, RNA splicing, RNA splicing, via transesterification reactions, mRNA processing, mRNA splicing, via spliceosome, positive regulation of transcription by RNA polymerase II, spliceosomal complex assembly, spliceosomal tri-snRNP complex assembly; MF: RNA binding, identical protein binding, protein binding, protein-macromolecule adaptor activity, ribonucleoprotein complex binding; CC: U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, centrosome, ciliary basal body, cytosol, membrane, nuclear speck, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: O94906
Entrez ID: 24148
|
Does Knockout of GTF2E2 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
GTF2E2
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: GTF2E2 (general transcription factor IIE subunit 2)
Type: protein-coding
Summary: The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA binding, RNA polymerase II general transcription initiation factor activity, TFIIH-class transcription factor complex binding, protein binding; CC: cytosol, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIE complex
Pathways: Basal transcription factors - Homo sapiens (human), Disease, Eukaryotic Transcription Initiation, Gene expression (Transcription), HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, RNA polymerase II transcribes snRNA genes, Transcription of the HIV genome, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human)
UniProt: P29084
Entrez ID: 2961
|
Does Knockout of BHMT2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
BHMT2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: BHMT2 (betaine--homocysteine S-methyltransferase 2)
Type: protein-coding
Summary: Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
Gene Ontology: BP: L-methionine salvage, S-adenosylmethionine metabolic process, S-methylmethionine metabolic process, amino-acid betaine metabolic process, methionine biosynthetic process, methylation, modified amino acid metabolic process; MF: S-methylmethionine-homocysteine S-methyltransferase activity, S-methyltransferase activity, betaine-homocysteine S-methyltransferase activity, metal ion binding, methyltransferase activity, transferase activity, zinc ion binding; CC: cytosol, extracellular exosome
Pathways: Allograft Rejection, Cysteine and methionine metabolism - Homo sapiens (human), Metabolism, Metabolism of amino acids and derivatives, One-carbon metabolism and related pathways, Sulfur amino acid metabolism, methionine salvage
UniProt: Q9H2M3
Entrez ID: 23743
|
Does Knockout of GEMIN8 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
GEMIN8
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GEMIN8 (gem nuclear organelle associated protein 8)
Type: protein-coding
Summary: The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010].
Gene Ontology: BP: RNA splicing, mRNA processing, spliceosomal snRNP assembly; CC: Gemini of Cajal bodies, SMN complex, SMN-Sm protein complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Disease, Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, RNA transport - Homo sapiens (human), SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, Viral Infection Pathways, snRNP Assembly
UniProt: Q9NWZ8
Entrez ID: 54960
|
Does Knockout of MAP2K4 in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
MAP2K4
|
response to virus
|
Hepatoma Cell Line
|
Gene: MAP2K4 (mitogen-activated protein kinase kinase 4)
Type: protein-coding
Summary: This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: Fc-epsilon receptor signaling pathway, JNK cascade, MAPK cascade, apoptotic process, cellular response to mechanical stimulus, cellular response to stress, cellular senescence, intrinsic apoptotic signaling pathway in response to hydrogen peroxide, negative regulation of motor neuron apoptotic process, response to wounding, signal transduction, smooth muscle cell apoptotic process; MF: ATP binding, JUN kinase kinase activity, MAP kinase kinase activity, kinase activity, molecular adaptor activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleus
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, Apoptosis, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Bacterial Infection Pathways, CD40/CD40L signaling, CDC42 signaling events, Cardiac Hypertrophic Response, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Cellular roles of Anthrax toxin, Ceramide signaling pathway, Chagas disease - Homo sapiens (human), Cytokine Signaling in Immune system, Disease, Ephrin B reverse signaling, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Epithelial to mesenchymal transition in colorectal cancer, Epstein-Barr virus infection - Homo sapiens (human), ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), ErbB1 downstream signaling, FCERI mediated MAPK activation, Fas ligand pathway and stress induction of heat shock proteins, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc epsilon receptor (FCERI) signaling, Fc-epsilon receptor I signaling in mast cells, Fluid shear stress and atherosclerosis - Homo sapiens (human), Glioblastoma signaling pathways, GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hepatitis B - Homo sapiens (human), Hepatitis B infection, Host-pathogen interaction of human coronaviruses - MAPK signaling, Human T-cell leukemia virus 1 infection - Homo sapiens (human), IL-1 signaling pathway, IL-6 signaling pathway, IL1, IL6, IL6-mediated signaling events, Immune System, Infectious disease, Innate Immune System, Insulin Signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, JNK signaling in the CD4+ TCR pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Lipid and atherosclerosis - Homo sapiens (human), MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK Cascade, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), MicroRNAs in cardiomyocyte hypertrophy, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Nephrin/Neph1 signaling in the kidney podocyte, Oxidative Damage, Oxidative Stress Induced Senescence, PDGF Pathway, PDGFR-beta signaling pathway, RAC1 signaling pathway, Regulation of Androgen receptor activity, Regulation of p38-alpha and p38-beta, Regulation of toll-like receptor signaling pathway, Relaxin signaling pathway - Homo sapiens (human), RhoA signaling pathway, Salmonella infection - Homo sapiens (human), Signaling by Interleukins, Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by focal adhesion kinase, Structural Pathway of Interleukin 1 (IL-1), TGF-beta Signaling Pathway, TNF signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAIL signaling pathway, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like Receptor Signaling Pathway, Toll-like receptor signaling pathway - Homo sapiens (human), Translation inhibitors in chronically activated PDGFRA cells, Uptake and actions of bacterial toxins, Uptake and function of anthrax toxins, VEGFA-VEGFR2 Signaling Pathway, VEGFR3 signaling in lymphatic endothelium, Wnt signaling pathway and pluripotency, Yersinia infection - Homo sapiens (human), angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling, ceramide signaling pathway, egf signaling pathway, fas signaling pathway (cd95), fc epsilon receptor i signaling in mast cells, inhibition of cellular proliferation by gleevec, keratinocyte differentiation, links between pyk2 and map kinases, map kinase inactivation of smrt corepressor, mapkinase signaling pathway, p38 MAPK Signaling Pathway, p38 mapk signaling pathway, pdgf signaling pathway, t cell receptor signaling pathway, tnf/stress related signaling, tnfr1 signaling pathway, toll-like receptor pathway
UniProt: P45985
Entrez ID: 6416
|
Does Knockout of DMRTA2 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
DMRTA2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: DMRTA2 (DMRT like family A2)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and sex differentiation. Predicted to act upstream of or within nervous system development and skeletal muscle cell differentiation. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cerebral cortex regionalization, dopaminergic neuron differentiation, neuroblast proliferation, neuron fate specification, positive regulation of neuroblast proliferation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, sex differentiation, skeletal muscle cell differentiation, stem cell differentiation, stem cell fate specification; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: Q96SC8
Entrez ID: 63950
|
Does Knockout of ACO1 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
ACO1
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: ACO1 (aconitase 1)
Type: protein-coding
Summary: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014].
Gene Ontology: BP: NADPH regeneration, citrate metabolic process, intestinal absorption, intracellular iron ion homeostasis, negative regulation of translation, post-embryonic development, regulation of gene expression, regulation of translation, response to iron(II) ion, tricarboxylic acid cycle; MF: 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, RNA binding, aconitate hydratase activity, iron-responsive element binding, iron-sulfur cluster binding, lyase activity, mRNA regulatory element binding translation repressor activity, metal ion binding, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, endoplasmic reticulum, extracellular exosome, mitochondrion
Pathways: Citrate cycle (TCA cycle) - Homo sapiens (human), Glyoxylate and dicarboxylate metabolism - Homo sapiens (human), Iron metabolism in placenta, Iron uptake and transport, Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, NADPH regeneration, TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc), TCA cycle, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate, Transport of small molecules, Warburg Effect, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P21399
Entrez ID: 48
|
Does Knockout of ABT1 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
ABT1
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: ABT1 (activator of basal transcription 1)
Type: protein-coding
Summary: Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, small-subunit processome assembly, spinal cord motor neuron differentiation, transcription by RNA polymerase II; MF: DNA binding, RNA binding, nucleic acid binding, protein binding, transcription coactivator activity; CC: nucleolus, nucleus, transcription regulator complex
Pathways:
UniProt: Q9ULW3
Entrez ID: 29777
|
Does Knockout of SMIM10L1 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
SMIM10L1
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: SMIM10L1 (small integral membrane protein 10 like 1)
Type: protein-coding
Summary: Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology:
Pathways:
UniProt: P0DMW3
Entrez ID: 100129361
|
Does Knockout of GRK5 in Bladder Carcinoma causally result in cell proliferation?
| 0
| 489
|
Knockout
|
GRK5
|
cell proliferation
|
Bladder Carcinoma
|
Gene: GRK5 (G protein-coupled receptor kinase 5)
Type: protein-coding
Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, Wnt signaling pathway, adenylate cyclase-modulating G protein-coupled receptor signaling pathway, apoptotic process, fat cell differentiation, negative regulation of apoptotic process, positive regulation of cell population proliferation, protein autophosphorylation, regulation of G protein-coupled receptor signaling pathway, regulation of cell cycle, regulation of signal transduction, signal transduction, tachykinin receptor signaling pathway; MF: ATP binding, G protein-coupled receptor kinase activity, beta-adrenergic receptor kinase activity, kinase activity, lipid binding, nucleotide binding, phospholipid binding, protein binding, protein kinase C binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, membrane, nuclear membrane, nuclear speck, nucleus, plasma membrane
Pathways: Alpha-synuclein signaling, Calcium Regulation in the Cardiac Cell, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Endocytosis - Homo sapiens (human), G alpha (q) signalling events, G alpha (s) signalling events, GPCR downstream signalling, Morphine addiction - Homo sapiens (human), Myometrial relaxation and contraction pathways, Signal Transduction, Signaling by GPCR
UniProt: P34947
Entrez ID: 2869
|
Does Knockout of DDX11 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
DDX11
|
cell proliferation
|
Bladder Carcinoma
|
Gene: DDX11 (DEAD/H-box helicase 11)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, cellular response to bleomycin, cellular response to cisplatin, cellular response to hydroxyurea, establishment of sister chromatid cohesion, negative regulation of protein binding, nucleobase-containing compound metabolic process, nucleolar chromatin organization, positive regulation of chromatin binding, positive regulation of double-strand break repair, positive regulation of sister chromatid cohesion, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, replication fork processing, sister chromatid cohesion; MF: 4 iron, 4 sulfur cluster binding, 5'-3' DNA helicase activity, ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, ATP-dependent activity, acting on RNA, DNA binding, DNA helicase activity, DNA replication origin binding, G-quadruplex DNA binding, RNA binding, catalytic activity, acting on a nucleic acid, chromatin binding, double-stranded DNA binding, helicase activity, hydrolase activity, hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, iron-sulfur cluster binding, isomerase activity, metal ion binding, nucleic acid binding, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded RNA binding, triplex DNA binding; CC: centrosome, chromatin, chromosome, cytoplasm, cytoskeleton, extracellular exosome, midbody, mitotic cohesin complex, nucleolus, nucleoplasm, nucleus, spindle pole
Pathways: Cellular responses to stimuli, Cellular responses to stress, IRE1alpha activates chaperones, Unfolded Protein Response (UPR), XBP1(S) activates chaperone genes
UniProt: Q96FC9
Entrez ID: 1663
|
Does Knockout of DDOST in Lung Cancer Cell Line causally result in response to virus?
| 0
| 1,433
|
Knockout
|
DDOST
|
response to virus
|
Lung Cancer Cell Line
|
Gene: DDOST (dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit)
Type: protein-coding
Summary: This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell activation, protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation, regulation of protein stability, response to cytokine; MF: enzyme activator activity, protein binding; CC: azurophil granule membrane, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B, plasma membrane
Pathways: AGE-RAGE pathway, Adaptive Immune System, Adherens junctions interactions, Advanced glycosylation endproduct receptor signaling, Asparagine N-linked glycosylation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Innate Immune System, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, N-Glycan biosynthesis - Homo sapiens (human), Neutrophil degranulation, PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation of Structural Proteins, Various types of N-glycan biosynthesis - Homo sapiens (human), Viral Infection Pathways
UniProt: P39656
Entrez ID: 1650
|
Does Knockout of POLR1B in Hepatoma Cell Line causally result in response to virus?
| 1
| 2,437
|
Knockout
|
POLR1B
|
response to virus
|
Hepatoma Cell Line
|
Gene: POLR1B (RNA polymerase I subunit B)
Type: protein-coding
Summary: Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: DNA-templated transcription, embryo implantation, neural crest formation, nucleologenesis, rRNA transcription; MF: 5'-3' RNA polymerase activity, DNA binding, DNA-directed RNA polymerase activity, DNA/RNA hybrid binding, metal ion binding, nucleotidyltransferase activity, protein binding, ribonucleoside binding, transferase activity, zinc ion binding; CC: DNA-directed RNA polymerase complex, RNA polymerase I complex, chromosome, cytosol, fibrillar center, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, Pyrimidine metabolism, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA polymerase - Homo sapiens (human), TNFalpha, tumor suppressor arf inhibits ribosomal biogenesis
UniProt: Q9H9Y6
Entrez ID: 84172
|
Does Knockout of TUBAL3 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
TUBAL3
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: TUBAL3 (tubulin alpha like 3)
Type: protein-coding
Summary: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be active in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cytoskeleton organization, microtubule cytoskeleton organization, microtubule-based process, mitotic cell cycle; MF: GTP binding, hydrolase activity, metal ion binding, nucleotide binding, structural constituent of cytoskeleton; CC: cytoplasm, cytoskeleton, microtubule
Pathways: Activation of AMPK downstream of NMDARs, Activation of NMDA receptors and postsynaptic events, Adaptive Immune System, Aggrephagy, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Apoptosis - Homo sapiens (human), Asparagine N-linked glycosylation, Assembly and cell surface presentation of NMDA receptors, Autophagy, Axon guidance, COPI-dependent Golgi-to-ER retrograde traffic, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Carboxyterminal post-translational modifications of tubulin, Cargo trafficking to the periciliary membrane, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Chaperonin-mediated protein folding, Cilium Assembly, Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding, Cytokine Signaling in Immune system, Developmental Biology, Disease, EML4 and NUDC in mitotic spindle formation, ER to Golgi Anterograde Transport, Factors involved in megakaryocyte development and platelet production, Formation of tubulin folding intermediates by CCT/TriC, G2/M Transition, Gap junction - Homo sapiens (human), Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Golgi-to-ER retrograde transport, HCMV Early Events, HCMV Infection, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Hemostasis, Huntington disease - Homo sapiens (human), Immune System, Infectious disease, Interferon Signaling, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, L1CAM interactions, M Phase, MHC class II antigen presentation, Macroautophagy, Membrane Trafficking, Metabolism of proteins, Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Nervous system development, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Nuclear Envelope (NE) Reassembly, Organelle biogenesis and maintenance, PKR-mediated signaling, Parkin-Ubiquitin Proteasomal System pathway, Parkinson disease - Homo sapiens (human), Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Phagosome - Homo sapiens (human), Post NMDA receptor activation events, Post-chaperonin tubulin folding pathway, Post-translational protein modification, Prion disease - Homo sapiens (human), Protein folding, RHO GTPase Effectors, RHO GTPases Activate Formins, RHO GTPases activate IQGAPs, Recruitment of NuMA to mitotic centrosomes, Recycling pathway of L1, Resolution of Sister Chromatid Cohesion, Salmonella infection - Homo sapiens (human), Sealing of the nuclear envelope (NE) by ESCRT-III, Selective autophagy, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, The role of GTSE1 in G2/M progression after G2 checkpoint, Tight junction - Homo sapiens (human), Translocation of SLC2A4 (GLUT4) to the plasma membrane, Transmission across Chemical Synapses, Transport of connexons to the plasma membrane, Transport to the Golgi and subsequent modification, Vesicle-mediated transport, Viral Infection Pathways
UniProt: A6NHL2
Entrez ID: 79861
|
Does Knockout of CEP89 in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
CEP89
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: CEP89 (centrosomal protein 89)
Type: protein-coding
Summary: Involved in non-motile cilium assembly. Acts upstream of or within cilium assembly. Located in several cellular components, including cytosol; microtubule cytoskeleton; and non-motile cilium. Part of ciliary transition fiber. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell projection organization, chemical synaptic transmission, cilium assembly, mitochondrial cytochrome c oxidase assembly, mitochondrion organization, non-motile cilium assembly; CC: centriole, centrosome, ciliary basal body, ciliary transition fiber, cilium, cytoplasm, cytoskeleton, cytosol, mitochondrial intermembrane space, mitochondrion, motile cilium, non-motile cilium, nuclear body, spindle pole, synapse
Pathways:
UniProt: Q96ST8
Entrez ID: 84902
|
Does Knockout of DSC2 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
DSC2
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DSC2 (desmocollin 2)
Type: protein-coding
Summary: This gene encodes a member of the desmocollin protein subfamily. Desmocollins, along with desmogleins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmocollin family members on chromosome 18. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11, and reduced protein expression has been described in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: bundle of His cell-Purkinje myocyte adhesion involved in cell communication, cardiac muscle cell-cardiac muscle cell adhesion, cell adhesion, cell-cell adhesion, cellular response to starvation, homophilic cell adhesion via plasma membrane adhesion molecules, positive regulation of p38MAPK cascade, regulation of heart rate by cardiac conduction, regulation of ventricular cardiac muscle cell action potential; MF: calcium ion binding, cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication, metal ion binding, protein binding; CC: adherens junction, anchoring junction, cell junction, cornified envelope, cytoplasmic vesicle, desmosome, endoplasmic reticulum, extracellular exosome, intercalated disc, membrane, plasma membrane
Pathways: Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q02487
Entrez ID: 1824
|
Does Knockout of ITGA6 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
ITGA6
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: ITGA6 (integrin subunit alpha 6)
Type: protein-coding
Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: cell adhesion, cell-cell adhesion, cell-matrix adhesion, cell-substrate adhesion, cell-substrate junction assembly, ectodermal cell differentiation, integrin-mediated signaling pathway, leukocyte migration, nail development, negative regulation of extrinsic apoptotic signaling pathway, positive regulation of GTPase activity, positive regulation of apoptotic process, positive regulation of cell migration, positive regulation of neuron projection development, positive regulation of transcription by RNA polymerase II, skin morphogenesis; MF: cadherin binding, insulin-like growth factor I binding, metal ion binding, neuregulin binding, protein binding, signaling receptor activity; CC: cell surface, focal adhesion, integrin alpha6-beta1 complex, integrin alpha6-beta4 complex, integrin complex, membrane, plasma membrane
Pathways: Alpha 6 Beta 4 signaling pathway, Alpha6 beta4 integrin-ligand interactions, Alpha6Beta4Integrin, Arf6 trafficking events, Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human), Assembly of collagen fibrils and other multimeric structures, Basigin interactions, Beta1 integrin cell surface interactions, Cell adhesion molecules - Homo sapiens (human), Cell junction organization, Cell surface interactions at the vascular wall, Cell-Cell communication, Collagen formation, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Integumentary System, Developmental Lineage of Mammary Gland Alveolar Cells, Developmental Lineage of Mammary Gland Luminal Epithelial Cells, Developmental Lineage of Mammary Gland Myoepithelial Cells, Developmental Lineage of Mammary Stem Cells, Developmental Lineages of the Mammary Gland, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin, Dilated cardiomyopathy - Homo sapiens (human), ECM-receptor interaction - Homo sapiens (human), Ebola Virus Pathway on Host, Extracellular matrix organization, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), Hematopoietic cell lineage - Homo sapiens (human), Hemostasis, Hippo-Merlin Signaling Dysregulation, Human papillomavirus infection - Homo sapiens (human), Hypertrophic cardiomyopathy - Homo sapiens (human), Integrin cell surface interactions, Integrin-mediated Cell Adhesion, Laminin interactions, Mammary gland development pathway - Embryonic development (Stage 1 of 4), Non-integrin membrane-ECM interactions, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Plexin-D1 Signaling, Regulation of actin cytoskeleton - Homo sapiens (human), Regulation of apoptosis by parathyroid hormone-related protein, Small cell lung cancer, Small cell lung cancer - Homo sapiens (human), Syndecan interactions, Toxoplasmosis - Homo sapiens (human), Type I hemidesmosome assembly, Validated targets of C-MYC transcriptional repression, a6b1 and a6b4 Integrin signaling
UniProt: P23229
Entrez ID: 3655
|
Does Knockout of CDT1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
CDT1
|
cell proliferation
|
Cancer Cell Line
|
Gene: CDT1 (chromatin licensing and DNA replication factor 1)
Type: protein-coding
Summary: The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011].
Gene Ontology: BP: DNA replication, DNA replication checkpoint signaling, DNA replication preinitiation complex assembly, attachment of mitotic spindle microtubules to kinetochore, cell division, mitotic cell cycle, negative regulation of DNA-templated DNA replication, negative regulation of cell cycle, positive regulation of DNA replication, positive regulation of DNA-templated DNA replication, positive regulation of chromatin binding, regulation of DNA-templated DNA replication initiation, regulation of nuclear cell cycle DNA replication, response to sorbitol; MF: DNA binding, DNA polymerase binding, chromatin binding, protein binding; CC: chromosome, chromosome, centromeric region, kinetochore, nuclear body, nucleoplasm, nucleus
Pathways: Activation of the pre-replicative complex, Assembly of the pre-replicative complex, Cell Cycle, Cell Cycle, Mitotic, DNA Replication, DNA Replication Pre-Initiation, G1/S Transition, G1/S-Specific Transcription, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Retinoblastoma gene in cancer, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, cdk regulation of dna replication
UniProt: Q9H211
Entrez ID: 81620
|
Does Knockout of ANAPC4 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
ANAPC4
|
cell proliferation
|
Cancer Cell Line
|
Gene: ANAPC4 (anaphase promoting complex subunit 4)
Type: protein-coding
Summary: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle, regulation of mitotic metaphase/anaphase transition; MF: protein binding, protein phosphatase binding, ubiquitin-protein transferase activity; CC: anaphase-promoting complex, cytosol, nuclear periphery, nucleoplasm, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9UJX5
Entrez ID: 29945
|
Does Knockout of PAX6 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
PAX6
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: PAX6 (paired box 6)
Type: protein-coding
Summary: This gene encodes paired box protein Pax-6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to a conserved paired box domain, a hallmark feature of this gene family, the encoded protein also contains a homeobox domain. Both domains are known to bind DNA and function as regulators of gene transcription. Activity of this protein is key in the development of neural tissues, particularly the eye. This gene is regulated by multiple enhancers located up to hundreds of kilobases distant from this locus. Mutations in this gene or in the enhancer regions can cause ocular disorders such as aniridia and Peter's anomaly. Use of alternate promoters and alternative splicing results in multiple transcript variants encoding different isoforms. Interestingly, inclusion of a particular alternate coding exon has been shown to increase the length of the paired box domain and alter its DNA binding specificity. Consequently, isoforms that carry the shorter paired box domain regulate a different set of genes compared to the isoforms carrying the longer paired box domain. [provided by RefSeq, Mar 2019].
Gene Ontology: BP: anatomical structure morphogenesis, animal organ morphogenesis, anterior/posterior pattern specification, astrocyte differentiation, axon guidance, axonogenesis, blood vessel development, brain development, camera-type eye development, cell differentiation, cell fate commitment, cell fate determination, cell population proliferation, cellular response to leukemia inhibitory factor, central nervous system development, cerebral cortex development, cerebral cortex regionalization, chromatin remodeling, commitment of neuronal cell to specific neuron type in forebrain, cornea development in camera-type eye, dorsal/ventral axis specification, dorsal/ventral pattern formation, embryonic camera-type eye morphogenesis, epithelial cell differentiation, establishment of mitotic spindle orientation, eye development, eye photoreceptor cell development, forebrain development, forebrain dorsal/ventral pattern formation, forebrain-midbrain boundary formation, gene expression, glucose homeostasis, habenula development, iris morphogenesis, keratinocyte differentiation, lacrimal gland development, lens development in camera-type eye, negative regulation of epithelial cell proliferation, negative regulation of neural precursor cell proliferation, negative regulation of neuroblast proliferation, negative regulation of neurogenesis, negative regulation of neuron differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, nervous system process, neural precursor cell proliferation, neuroblast proliferation, neuron differentiation, neuron fate commitment, neuron migration, oligodendrocyte cell fate specification, pallium development, pancreatic A cell development, pituitary gland development, positive regulation of DNA-templated transcription, positive regulation of epithelial cell differentiation, positive regulation of gene expression, positive regulation of miRNA transcription, positive regulation of neuroblast proliferation, positive regulation of transcription by RNA polymerase II, protein localization to organelle, regionalization, regulation of DNA-templated transcription, regulation of asymmetric cell division, regulation of cell migration, regulation of gene expression, regulation of neurogenesis, regulation of neuron differentiation, regulation of timing of cell differentiation, regulation of transcription by RNA polymerase II, response to wounding, retina development in camera-type eye, salivary gland morphogenesis, sensory organ development, signal transduction involved in regulation of gene expression, smoothened signaling pathway, telencephalon regionalization, transcription by RNA polymerase II, type B pancreatic cell differentiation, ventral spinal cord development, visual perception; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, HMG box domain binding, R-SMAD binding, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, chromatin DNA binding, chromatin binding, co-SMAD binding, histone acetyltransferase binding, protein binding, protein kinase binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription coregulator binding, ubiquitin protein ligase binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Activation of HOX genes during differentiation, Activation of anterior HOX genes in hindbrain development during early embryogenesis, CDC42 signaling events, Cardiac Progenitor Differentiation, Developmental Biology, Ectoderm Differentiation, Formation of the anterior neural plate, Gastrulation, Incretin synthesis, secretion, and inactivation, Maturity onset diabetes of the young - Homo sapiens (human), Mesodermal commitment pathway, Metabolism of proteins, Peptide hormone metabolism, Regulation of beta-cell development, Regulation of gene expression in beta cells, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
UniProt: P26367
Entrez ID: 5080
|
Does Knockout of MRPL4 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
MRPL4
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: MRPL4 (mitochondrial ribosomal protein L4)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9BYD3
Entrez ID: 51073
|
Does Knockout of HSD17B11 in Monocytic Leukemia Cell Line causally result in RNA accumulation?
| 0
| 1,968
|
Knockout
|
HSD17B11
|
RNA accumulation
|
Monocytic Leukemia Cell Line
|
Gene: HSD17B11 (hydroxysteroid 17-beta dehydrogenase 11)
Type: protein-coding
Summary: Short-chain alcohol dehydrogenases, such as HSD17B11, metabolize secondary alcohols and ketones (Brereton et al., 2001 [PubMed 11165019]).[supplied by OMIM, Jun 2009].
Gene Ontology: BP: androgen catabolic process, estrogen biosynthetic process, lipid metabolic process, steroid biosynthetic process; MF: estradiol 17-beta-dehydrogenase [NAD(P)+] activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding, steroid dehydrogenase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, lipid droplet
Pathways: Estrogen biosynthesis, Metabolism, Metabolism of lipids, Metabolism of steroid hormones, Metabolism of steroids, estradiol biosynthesis I, superpathway of steroid hormone biosynthesis
UniProt: Q8NBQ5
Entrez ID: 51170
|
Does Knockout of TNFSF14 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
TNFSF14
|
cell proliferation
|
Cancer Cell Line
|
Gene: TNFSF14 (TNF superfamily member 14)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell activation, T cell chemotaxis, T cell costimulation, T cell homeostasis, T cell proliferation, apoptotic process, cell communication, cell surface receptor signaling pathway, cellular response to mechanical stimulus, immune response, positive regulation of T cell chemotaxis, positive regulation of canonical NF-kappaB signal transduction, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of myoblast differentiation, positive regulation of myoblast fusion, positive regulation of non-canonical NF-kappaB signal transduction, signal transduction, signaling; MF: cysteine-type endopeptidase inhibitor activity involved in apoptotic process, cytokine activity, identical protein binding, protein binding, signaling receptor binding, tumor necrosis factor receptor binding; CC: cytoplasm, extracellular region, extracellular space, membrane, plasma membrane
Pathways: Cytokine-cytokine receptor interaction - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), NF-kappa B signaling pathway - Homo sapiens (human), Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
UniProt: O43557
Entrez ID: 8740
|
Does Knockout of EVPL in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 0
| 1,397
|
Knockout
|
EVPL
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: EVPL (envoplakin)
Type: protein-coding
Summary: This gene encodes a member of the plakin family of proteins that forms a component of desmosomes and the epidermal cornified envelope. This gene is located in the tylosis oesophageal cancer locus on chromosome 17q25, and its deletion is associated with both familial and sporadic forms of oesophageal squamous cell carcinoma. Patients suffering from the autoimmune mucocutaneous disorder, paraneoplastic pemphigus, develop antibodies against the encoded protein. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: epidermis development, intermediate filament cytoskeleton organization, keratinization, keratinocyte differentiation, peptide cross-linking, regulation of antibacterial peptide production, wound healing; MF: cadherin binding, structural molecule activity; CC: anchoring junction, cornified envelope, cytoplasm, cytoskeleton, cytosol, desmosome, extracellular exosome, intermediate filament, intermediate filament cytoskeleton, membrane
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization, Validated transcriptional targets of TAp63 isoforms
UniProt: Q92817
Entrez ID: 2125
|
Does Knockout of PRKCSH in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,032
|
Knockout
|
PRKCSH
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PRKCSH (PRKCSH beta subunit of glucosidase II)
Type: protein-coding
Summary: This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
Gene Ontology: BP: N-glycan processing, intracellular signal transduction, liver development; MF: calcium ion binding, metal ion binding, phosphoprotein binding, protein binding, protein kinase C binding, transmembrane transporter binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen, glucosidase II complex, intracellular membrane-bounded organelle
Pathways: Adherens junctions interactions, Advanced glycosylation endproduct receptor signaling, Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Disease, Fibroblast growth factor-1, Immune System, Infectious disease, Innate Immune System, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Post-translational protein modification, Post-translational protein phosphorylation, Protein processing in endoplasmic reticulum - Homo sapiens (human), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-2 Infection, Translation of Structural Proteins, Viral Infection Pathways
UniProt: P14314
Entrez ID: 5589
|
Does Knockout of TM4SF4 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
TM4SF4
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: TM4SF4 (transmembrane 4 L six family member 4)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011].
Gene Ontology: CC: membrane
Pathways:
UniProt: P48230
Entrez ID: 7104
|
Does Knockout of TFAP4 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
TFAP4
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: TFAP4 (transcription factor AP-4)
Type: protein-coding
Summary: Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009].
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, cellular response to dexamethasone stimulus, host-mediated activation of viral transcription, host-mediated suppression of viral transcription, negative regulation of DNA binding, negative regulation of DNA-templated transcription, negative regulation of cell population proliferation, negative regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of gene expression, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of transcription by RNA polymerase II, protein-containing complex assembly, regulation of mitotic cell cycle phase transition, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, histone deacetylase binding, protein binding, protein dimerization activity, protein homodimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding; CC: chromatin, mitochondrion, nucleoplasm, nucleus, transcription repressor complex
Pathways: Proteoglycans in cancer - Homo sapiens (human)
UniProt: Q01664
Entrez ID: 7023
|
Does Knockout of RIOK2 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
RIOK2
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: RIOK2 (RIO kinase 2)
Type: protein-coding
Summary: Predicted to enable protein kinase activity. Involved in several processes, including positive regulation of rRNA processing; positive regulation of ribosomal small subunit export from nucleus; and regulation of mitotic metaphase/anaphase transition. Located in cytoplasm. Part of preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of SSU-rRNA, positive regulation of rRNA processing, positive regulation of ribosomal small subunit export from nucleus, protein autophosphorylation, regulation of mitotic metaphase/anaphase transition, ribosomal small subunit biogenesis, ribosome biogenesis; MF: ATP binding, catalytic activity, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9BVS4
Entrez ID: 55781
|
Does Knockout of FH in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
FH
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: FH (fumarate hydratase)
Type: protein-coding
Summary: The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA damage response, DNA repair, arginine metabolic process, fumarate metabolic process, homeostasis of number of cells within a tissue, malate metabolic process, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair via nonhomologous end joining, regulation of arginine metabolic process, tricarboxylic acid cycle, urea cycle; MF: catalytic activity, fumarate hydratase activity, histone binding, lyase activity, protein binding; CC: chromosome, cytoplasm, cytosol, extracellular exosome, mitochondrial matrix, mitochondrion, nucleus, site of double-strand break
Pathways: 2-ketoglutarate dehydrogenase complex deficiency, Aerobic respiration and respiratory electron transport, Amino Acid metabolism, Citrate cycle (TCA cycle) - Homo sapiens (human), Citric Acid Cycle, Citric acid cycle (TCA cycle), Congenital lactic acidosis, Cushing syndrome - Homo sapiens (human), Disorders of the Krebs cycle, Fumarase deficiency, Glutaminolysis and Cancer, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of proteins, Mitochondrial complex II deficiency, Mitochondrial protein degradation, Pathways in cancer - Homo sapiens (human), Pyruvate dehydrogenase deficiency (E2), Pyruvate dehydrogenase deficiency (E3), Pyruvate metabolism - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), TCA Cycle (aka Krebs or citric acid cycle), TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc), TCA cycle, TCA cycle in senescence, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate, Type 2 papillary renal cell carcinoma, Warburg Effect, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P07954
Entrez ID: 2271
|
Does Knockout of NPIPB6 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 80
|
Knockout
|
NPIPB6
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: NPIPB6 (nuclear pore complex interacting protein family member B6)
Type: protein-coding
Summary: Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: E9PJ23
Entrez ID: 728741
|
Does Knockout of OR5A2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
OR5A2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: OR5A2 (olfactory receptor family 5 subfamily A member 2)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, odorant binding, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGI9
Entrez ID: 219981
|
Does Knockout of DDX51 in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
DDX51
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: DDX51 (DEAD-box helicase 51)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in rRNA processing. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: rRNA processing, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding; CC: membrane, nucleolus, nucleus
Pathways:
UniProt: Q8N8A6
Entrez ID: 317781
|
Does Knockout of IL31 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,119
|
Knockout
|
IL31
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: IL31 (interleukin 31)
Type: protein-coding
Summary: IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: immune system process, signal transduction; MF: cytokine activity, cytokine receptor binding, protein binding; CC: extracellular region, extracellular space
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), IL-6-type cytokine receptor ligand interactions, Immune System, Interleukin-6 family signaling, Signaling by Interleukins
UniProt: Q6EBC2
Entrez ID: 386653
|
Does Knockout of KLHL13 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
KLHL13
|
response to virus
|
Hepatoma Cell Line
|
Gene: KLHL13 (kelch like family member 13)
Type: protein-coding
Summary: This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: cell division, protein ubiquitination, regulation of cytokinesis; MF: cullin family protein binding, protein binding, ubiquitin-protein transferase activity; CC: Cul3-RING ubiquitin ligase complex, cytosol
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Aurora B signaling, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Neddylation, Post-translational protein modification, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9P2N7
Entrez ID: 90293
|
Does Knockout of TNNI2 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
TNNI2
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: TNNI2 (troponin I2, fast skeletal type)
Type: protein-coding
Summary: This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: cardiac muscle contraction, positive regulation of DNA-templated transcription, skeletal muscle contraction; MF: actin binding, protein binding, troponin T binding; CC: cytosol, nucleus, troponin complex
Pathways: Acebutolol Action Pathway, Alprenolol Action Pathway, Amiodarone Action Pathway, Amlodipine Action Pathway, Arbutamine Action Pathway, Atenolol Action Pathway, Betaxolol Action Pathway, Bevantolol Action Pathway, Bisoprolol Action Pathway, Bopindolol Action Pathway, Bupranolol Action Pathway, Carteolol Action Pathway, Carvedilol Action Pathway, Diltiazem Action Pathway, Disopyramide Action Pathway, Dobutamine Action Pathway, Epinephrine Action Pathway, Esmolol Action Pathway, Felodipine Action Pathway, Flecainide Action Pathway, Fosphenytoin (Antiarrhythmic) Action Pathway, Ibutilide Action Pathway, Isoprenaline Action Pathway, Isradipine Action Pathway, Labetalol Action Pathway, Levobunolol Action Pathway, Lidocaine (Antiarrhythmic) Action Pathway, Metipranolol Action Pathway, Metoprolol Action Pathway, Mexiletine Action Pathway, Muscle contraction, Muscle/Heart Contraction, Nadolol Action Pathway, Nebivolol Action Pathway, Nifedipine Action Pathway, Nimodipine Action Pathway, Nisoldipine Action Pathway, Nitrendipine Action Pathway, Oxprenolol Action Pathway, Penbutolol Action Pathway, Phenytoin (Antiarrhythmic) Action Pathway, Pindolol Action Pathway, Practolol Action Pathway, Procainamide (Antiarrhythmic) Action Pathway, Propranolol Action Pathway, Quinidine Action Pathway, Sotalol Action Pathway, Striated Muscle Contraction, Striated Muscle Contraction Pathway, Timolol Action Pathway, Tocainide Action Pathway, Verapamil Action Pathway
UniProt: P48788
Entrez ID: 7136
|
Does Knockout of ARID3B in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
ARID3B
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: ARID3B (AT-rich interaction domain 3B)
Type: protein-coding
Summary: This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, protein binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q8IVW6
Entrez ID: 10620
|
Does Knockout of PLEKHF1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,437
|
Knockout
|
PLEKHF1
|
response to virus
|
Hepatoma Cell Line
|
Gene: PLEKHF1 (pleckstrin homology and FYVE domain containing 1)
Type: protein-coding
Summary: Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in endosome organization; positive regulation of autophagy; and protein localization to plasma membrane. Located in lysosome. Colocalizes with endosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: apoptotic process, endosome organization, endosome to lysosome transport, positive regulation of autophagy, protein localization to plasma membrane, vesicle organization; MF: metal ion binding, phosphatidylinositol binding, phosphatidylinositol-3-phosphate binding, phosphatidylinositol-4-phosphate binding, phosphatidylinositol-5-phosphate binding, protein binding, zinc ion binding; CC: cytoplasm, early endosome, endosome, endosome membrane, lysosomal membrane, lysosome, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q96S99
Entrez ID: 79156
|
Does Knockout of CD70 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 0
| 699
|
Knockout
|
CD70
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: CD70 (CD70 molecule)
Type: protein-coding
Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell mediated immunity, B cell proliferation, CD27 signaling pathway, T cell activation, T cell mediated immunity, T cell proliferation, adaptive immune memory response involving T cells and B cells, extrinsic apoptotic signaling pathway, immune response, lymphocyte proliferation, positive regulation of T cell proliferation, tumor necrosis factor-mediated signaling pathway; MF: protein binding, receptor ligand activity, tumor necrosis factor receptor binding; CC: extracellular exosome, membrane, plasma membrane
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Immune System, TNFR2 non-canonical NF-kB pathway, TNFs bind their physiological receptors
UniProt: P32970
Entrez ID: 970
|
Does Knockout of CABS1 in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
CABS1
|
response to virus
|
Hepatoma Cell Line
|
Gene: CABS1 (calcium binding protein, spermatid associated 1)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in flagellated sperm motility and spermatogenesis. Predicted to be located in acrosomal vesicle and sperm principal piece. Predicted to be active in mitochondrial inner membrane and motile cilium. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: flagellated sperm motility, spermatogenesis; MF: calcium ion binding; CC: acrosomal vesicle, cell projection, cilium, cytoplasm, cytoplasmic vesicle, membrane, mitochondrial inner membrane, mitochondrion, motile cilium, sperm principal piece
Pathways:
UniProt: Q96KC9
Entrez ID: 85438
|
Does Knockout of ZNF835 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
ZNF835
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: ZNF835 (zinc finger protein 835)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q9Y2P0
Entrez ID: 90485
|
Does Knockout of OR2W3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
OR2W3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: OR2W3 (olfactory receptor family 2 subfamily W member 3)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Male infertility, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q7Z3T1
Entrez ID: 343171
|
Does Knockout of ZNF484 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
ZNF484
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: ZNF484 (zinc finger protein 484)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q5JVG2
Entrez ID: 83744
|
Does Knockout of PRDX5 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
PRDX5
|
response to virus
|
Huh-7 Cell
|
Gene: PRDX5 (peroxiredoxin 5)
Type: protein-coding
Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein interacts with peroxisome receptor 1 and plays an antioxidant protective role in different tissues under normal conditions and during inflammatory processes. The use of alternate transcription start sites is thought to result in transcript variants that use different in-frame translational start codons to generate isoforms that are targeted to the mitochondrion (isoform L) or peroxisome/cytoplasm (isoform S). Multiple related pseudogenes have been defined for this gene. [provided by RefSeq, Nov 2017].
Gene Ontology: BP: cell redox homeostasis, cellular oxidant detoxification, cellular response to oxidative stress, cellular response to reactive oxygen species, hydrogen peroxide catabolic process, inflammatory response, negative regulation of apoptotic process, negative regulation of oxidoreductase activity, negative regulation of transcription by RNA polymerase III, positive regulation of collagen biosynthetic process, reactive nitrogen species metabolic process, regulation of apoptosis involved in tissue homeostasis, response to oxidative stress; MF: RNA polymerase III transcription regulatory region sequence-specific DNA binding, antioxidant activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, identical protein binding, oxidoreductase activity, peroxidase activity, peroxynitrite reductase activity, protein binding, signaling receptor binding, thioredoxin peroxidase activity, thioredoxin-dependent peroxiredoxin activity; CC: cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, extracellular space, intracellular membrane-bounded organelle, mitochondrial matrix, mitochondrion, nucleus, perinuclear region of cytoplasm, peroxisomal matrix, peroxisome
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Detoxification of Reactive Oxygen Species, Peroxisome - Homo sapiens (human), Selenium Micronutrient Network, thioredoxin pathway
UniProt: P30044
Entrez ID: 25824
|
Does Knockout of FOXD4L6 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 69
|
Knockout
|
FOXD4L6
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FOXD4L6 (forkhead box D4 like 6)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: anatomical structure morphogenesis, cell differentiation, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific DNA binding; CC: chromatin, nucleus
Pathways:
UniProt: Q3SYB3
Entrez ID: 653404
|
Does Knockout of RNF139 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
RNF139
|
cell proliferation
|
Cancer Cell Line
|
Gene: RNF139 (ring finger protein 139)
Type: protein-coding
Summary: The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ERAD pathway, endoplasmic reticulum mannose trimming, negative regulation of cell population proliferation, negative regulation of translation, positive regulation of ubiquitin-dependent protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein destabilization, protein ubiquitination, regulation of ER to Golgi vesicle-mediated transport, regulation of protein processing; MF: metal ion binding, protease binding, protein binding, signaling receptor activity, transferase activity, ubiquitin protein ligase activity, ubiquitin-like protein transferase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: Derlin-1 retrotranslocation complex, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum quality control compartment, membrane
Pathways: Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, ER Quality Control Compartment (ERQC), Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Post-translational protein modification, Sterol regulatory element-binding proteins (SREBP) signaling
UniProt: Q8WU17
Entrez ID: 11236
|
Does Knockout of LSM7 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
LSM7
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: LSM7 (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, nuclear-transcribed mRNA catabolic process; MF: RNA binding, U6 snRNA binding, protein binding; CC: Lsm1-7-Pat1 complex, Lsm2-8 complex, U12-type spliceosomal complex, U2-type precatalytic spliceosome, U2-type prespliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, catalytic step 2 spliceosome, cytosol, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Homo sapiens (human), Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: Q9UK45
Entrez ID: 51690
|
Does Knockout of SNRPB2 in Prostate Cancer Cell Line causally result in cell proliferation?
| 1
| 843
|
Knockout
|
SNRPB2
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: SNRPB2 (small nuclear ribonucleoprotein polypeptide B2)
Type: protein-coding
Summary: The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, U1 snRNA binding, nucleic acid binding, protein binding; CC: U1 snRNP, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, cytoplasmic ribonucleoprotein granule, fibrillar center, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex, spliceosomal snRNP complex
Pathways: Ciliary landscape, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, spliceosomal assembly
UniProt: P08579
Entrez ID: 6629
|
Does Knockout of ATP2B2 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
ATP2B2
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ATP2B2 (ATPase plasma membrane Ca2+ transporting 2)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion transmembrane transport, calcium ion transport, monoatomic ion transmembrane transport, monoatomic ion transport, neuron differentiation, regulation of cardiac conduction, regulation of cytosolic calcium ion concentration, regulation of postsynaptic cytosolic calcium ion concentration, sensory perception of sound; MF: ATP binding, ATP hydrolysis activity, P-type calcium transporter activity, P-type calcium transporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration, PDZ domain binding, calcium ion binding, calmodulin binding, metal ion binding, nucleotide binding, protein binding; CC: GABA-ergic synapse, apical plasma membrane, basolateral plasma membrane, cytoplasm, dendritic spine membrane, extracellular exosome, glutamatergic synapse, intracellular membrane-bounded organelle, membrane, plasma membrane, postsynaptic density membrane, synapse
Pathways: Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Aldosterone synthesis and secretion - Homo sapiens (human), Calcium Regulation in the Cardiac Cell, Calcium signaling pathway - Homo sapiens (human), Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human), Mineral absorption - Homo sapiens (human), PKC-gamma calcium signaling pathway in ataxia, Pancreatic secretion - Homo sapiens (human), Salivary secretion - Homo sapiens (human), Sensory Perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Sensory processing of sound by outer hair cells of the cochlea, Vitamin D-sensitive calcium signaling in depression, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: Q01814
Entrez ID: 491
|
Does Knockout of ZSCAN30 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
ZSCAN30
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: ZSCAN30 (zinc finger and SCAN domain containing 30)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q86W11
Entrez ID: 100101467
|
Does Knockout of NCL in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
NCL
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: NCL (nucleolin)
Type: protein-coding
Summary: Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: angiogenesis, cellular response to epidermal growth factor stimulus, cellular response to leukemia inhibitory factor, negative regulation of insulin receptor signaling pathway, negative regulation of translation, positive regulation of mRNA splicing, via spliceosome, positive regulation of macromolecule biosynthetic process, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, regulation of RNA metabolic process, regulation of gene expression; MF: DNA binding, DNA topoisomerase binding, PH domain binding, RNA binding, identical protein binding, insulin receptor substrate binding, mRNA 5'-UTR binding, nucleic acid binding, protein binding, telomeric DNA binding; CC: cell cortex, chromosome, cornified envelope, cytoplasm, cytoplasmic ribonucleoprotein granule, extracellular exosome, macropinosome membrane, membrane, nucleolus, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, spliceosomal complex
Pathways: Aurora B signaling, Disease, Infectious disease, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Pathogenic Escherichia coli infection, Pathogenic Escherichia coli infection - Homo sapiens (human), Regulation of Telomerase, Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) attachment and entry, TCR, Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling, VEGFA-VEGFR2 Signaling Pathway, Validated targets of C-MYC transcriptional activation, Viral Infection Pathways, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P19338
Entrez ID: 4691
|
Does Knockout of MRPL45 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
MRPL45
|
cell proliferation
|
Melanoma Cell Line
|
Gene: MRPL45 (mitochondrial ribosomal protein L45)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. [provided by RefSeq, May 2013].
Gene Ontology: BP: mitochondrial translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways:
UniProt: A0A087WU62, A0A087X2D5, B4DEF8
Entrez ID: 84311
|
Does Knockout of C22orf23 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
C22orf23
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: C22orf23 (chromosome 22 open reading frame 23)
Type: protein-coding
Summary: chromosome 22 open reading frame 23
Gene Ontology:
Pathways:
UniProt: Q9BZE7
Entrez ID: 84645
|
Does Knockout of TAF10 in T-lymphoma cell line causally result in cell proliferation?
| 1
| 478
|
Knockout
|
TAF10
|
cell proliferation
|
T-lymphoma cell line
|
Gene: TAF10 (TATA-box binding protein associated factor 10)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription initiation, G1/S transition of mitotic cell cycle, RNA polymerase II preinitiation complex assembly, SAGA complex assembly, allantois development, apoptotic process, chromatin remodeling, embryonic placenta development, gene expression, hepatocyte differentiation, in utero embryonic development, lateral mesodermal cell differentiation, limb development, liver development, mRNA transcription by RNA polymerase II, multicellular organism growth, positive regulation of DNA-templated transcription, positive regulation of transcription initiation by RNA polymerase II, protein-containing complex assembly, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of gene expression, regulation of transcription by RNA polymerase II, somitogenesis, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase binding, enzyme binding, histone acetyltransferase activity, identical protein binding, nuclear estrogen receptor binding, promoter-specific chromatin binding, protein binding; CC: SAGA complex, cytoplasm, male germ cell nucleus, nucleoplasm, nucleus, perinuclear region of cytoplasm, transcription factor TFIID complex, transcription factor TFTC complex, transcription preinitiation complex
Pathways: Basal transcription factors - Homo sapiens (human), C-MYC pathway, Chromatin modifying enzymes, Chromatin organization, Deubiquitination, Disease, Gene expression (Transcription), Generic Transcription Pathway, HATs acetylate histones, HIV Infection, HIV Life Cycle, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of proteins, Post-translational protein modification, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Transcription of the HIV genome, Transcriptional Regulation by TP53, Ub-specific processing proteases, Validated targets of C-MYC transcriptional activation, Viral Infection Pathways
UniProt: Q12962
Entrez ID: 6881
|
Does Activation of COMMD4 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
COMMD4
|
protein/peptide accumulation
|
T cell
|
Gene: COMMD4 (COMM domain containing 4)
Type: protein-coding
Summary: Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasm, cytosol, nucleus, plasma membrane
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q9H0A8
Entrez ID: 54939
|
Does Knockout of FGF18 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 0
| 80
|
Knockout
|
FGF18
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: FGF18 (fibroblast growth factor 18)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: ERK1 and ERK2 cascade, anatomical structure morphogenesis, angiogenesis, cell population proliferation, cell-cell signaling, chondrocyte development, chondrocyte differentiation, endochondral ossification, fibroblast growth factor receptor signaling pathway, intramembranous ossification, lung development, neurogenesis, ossification, positive regulation of ERK1 and ERK2 cascade, positive regulation of MAP kinase activity, positive regulation of MAPK cascade, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of cell population proliferation, positive regulation of chondrocyte differentiation, positive regulation of endothelial cell chemotaxis to fibroblast growth factor, positive regulation of vascular endothelial growth factor receptor signaling pathway, regulation of cell migration, regulation of endothelial cell proliferation, regulation of sprouting angiogenesis, signal transduction, vascular endothelial growth factor receptor signaling pathway; MF: growth factor activity, type 1 fibroblast growth factor receptor binding, type 2 fibroblast growth factor receptor binding; CC: cytoplasm, extracellular region, extracellular space, nucleolus
Pathways: Activated point mutants of FGFR2, Breast cancer - Homo sapiens (human), Breast cancer pathway, Calcium signaling pathway - Homo sapiens (human), Constitutive Signaling by Aberrant PI3K in Cancer, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, ESC Pluripotency Pathways, Endochondral Ossification, Endochondral Ossification with Skeletal Dysplasias, FGFR2 ligand binding and activation, FGFR2 mutant receptor activation, FGFR2c ligand binding and activation, FGFR3 ligand binding and activation, FGFR3 mutant receptor activation, FGFR3 signaling in chondrocyte proliferation and terminal differentiation, FGFR3b ligand binding and activation, FGFR3c ligand binding and activation, FGFR4 ligand binding and activation, FGFRL1 modulation of FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Gastric cancer - Homo sapiens (human), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, Melanoma - Homo sapiens (human), Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, Osteoblast differentiation, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Pathways in cancer - Homo sapiens (human), Phospholipase C-mediated cascade; FGFR2, Phospholipase C-mediated cascade; FGFR3, Phospholipase C-mediated cascade; FGFR4, RAF/MAP kinase cascade, Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of actin cytoskeleton - Homo sapiens (human), SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR2 in disease, Signaling by FGFR3, Signaling by FGFR3 in disease, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by activated point mutants of FGFR3
UniProt: O76093
Entrez ID: 8817
|
Does Knockout of JARID2 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
JARID2
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: JARID2 (jumonji and AT-rich interaction domain containing 2)
Type: protein-coding
Summary: This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012].
Gene Ontology: BP: cardiac muscle cell proliferation, cell differentiation, cell population proliferation, cellular response to leukemia inhibitory factor, central nervous system development, chromatin organization, chromatin remodeling, facultative heterochromatin formation, liver development, negative regulation of DNA-templated transcription, negative regulation of cardiac muscle cell proliferation, negative regulation of transcription by RNA polymerase II, protein localization to pericentric heterochromatin, random inactivation of X chromosome, regulation of cell population proliferation, regulation of gene expression, spleen development, stem cell differentiation, system development, thymus development; MF: DNA binding, chromatin binding, histone H3K27 methyltransferase activity, histone demethylase activity, protein binding, ubiquitin binding, ubiquitin-modified histone reader activity; CC: ESC/E(Z) complex, chromatin, histone methyltransferase complex, mitochondrion, nucleoplasm, nucleus
Pathways: Endoderm differentiation, Interactome of polycomb repressive complex 2 (PRC2), Mesodermal commitment pathway, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
UniProt: Q92833
Entrez ID: 3720
|
Does Knockout of CDC73 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
CDC73
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CDC73 (cell division cycle 73)
Type: protein-coding
Summary: This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009].
Gene Ontology: BP: Wnt signaling pathway, cellular response to lipopolysaccharide, endodermal cell fate commitment, mRNA 3'-end processing, negative regulation of G1/S transition of mitotic cell cycle, negative regulation of apoptotic process, negative regulation of cell population proliferation, negative regulation of epithelial cell proliferation, negative regulation of fibroblast proliferation, negative regulation of myeloid cell differentiation, negative regulation of transcription by RNA polymerase II, positive regulation of Wnt signaling pathway, positive regulation of cell cycle G1/S phase transition, positive regulation of mRNA 3'-end processing, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, protein destabilization, regulation of cell growth, regulation of transcription by RNA polymerase II, stem cell population maintenance, transcription elongation by RNA polymerase II; MF: RNA polymerase II complex binding, protein binding; CC: Cdc73/Paf1 complex, chromosome, telomeric region, cytosol, nucleoplasm, nucleus
Pathways: E3 ubiquitin ligases ubiquitinate target proteins, Endoderm differentiation, Formation of RNA Pol II elongation complex , Formation of the beta-catenin:TCF transactivating complex, Gene expression (Transcription), Hedgehog 'on' state, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, Signal Transduction, Signaling by Hedgehog, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: Q6P1J9
Entrez ID: 79577
|
Does Knockout of GHRHR in Prostate Cancer Cell Line causally result in cell proliferation?
| 0
| 843
|
Knockout
|
GHRHR
|
cell proliferation
|
Prostate Cancer Cell Line
|
Gene: GHRHR (growth hormone releasing hormone receptor)
Type: protein-coding
Summary: This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, adenohypophysis development, adenylate cyclase-activating G protein-coupled receptor signaling pathway, cAMP/PKA signal transduction, cell maturation, cell surface receptor signaling pathway, cellular response to glucose stimulus, cellular response to insulin stimulus, determination of adult lifespan, establishment of localization in cell, growth hormone secretion, hormone metabolic process, hormone secretion, lactation, mammary gland development, positive regulation of cell population proliferation, positive regulation of circadian sleep/wake cycle, non-REM sleep, positive regulation of growth hormone secretion, positive regulation of hormone secretion, positive regulation of insulin-like growth factor receptor signaling pathway, positive regulation of multicellular organism growth, regulation of insulin-like growth factor receptor signaling pathway, regulation of intracellular steroid hormone receptor signaling pathway, regulation of protein metabolic process, response to estrogen, response to glucocorticoid, response to insulin, signal transduction, somatotropin secreting cell development; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, growth factor binding, growth hormone-releasing hormone receptor activity, peptide hormone binding, protein binding, transmembrane signaling receptor activity; CC: cell surface, cytoplasm, membrane, nuclear inner membrane, nuclear matrix, nuclear outer membrane, plasma membrane, sarcolemma, secretory granule
Pathways: Class B/2 (Secretin family receptors), G alpha (s) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class B Secretin-like, GPCRs, Other, Glucagon-type ligand receptors, Growth hormone synthesis, secretion and action - Homo sapiens (human), Neuroactive ligand-receptor interaction - Homo sapiens (human), Signal Transduction, Signaling by GPCR
UniProt: Q02643
Entrez ID: 2692
|
Does Knockout of ASZ1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 527
|
Knockout
|
ASZ1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: ASZ1 (ankyrin repeat, SAM and basic leucine zipper domain containing 1)
Type: protein-coding
Summary: Predicted to be involved in gamete generation and piRNA metabolic process. Predicted to be located in cytoplasm. Predicted to be active in pi-body. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell differentiation, male meiotic nuclear division, meiotic cell cycle, regulatory ncRNA-mediated gene silencing, spermatogenesis, transposable element silencing; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, pi-body
Pathways: Gene Silencing by RNA, Gene expression (Transcription), PIWI-interacting RNA (piRNA) biogenesis
UniProt: Q8WWH4
Entrez ID: 136991
|
Does Knockout of NDUFAB1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
NDUFAB1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: NDUFAB1 (NADH:ubiquinone oxidoreductase subunit AB1)
Type: protein-coding
Summary: Predicted to enable acyl binding activity; acyl carrier activity; and fatty acid binding activity. Involved in mitochondrial respiratory chain complex I assembly and protein lipoylation. Located in mitochondrion and nucleoplasm. Part of mitochondrial respiratory chain complex I. Colocalizes with mitochondrial large ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: [2Fe-2S] cluster assembly, aerobic respiration, fatty acid biosynthetic process, fatty acid metabolic process, iron-sulfur cluster assembly, lipid metabolic process, mitochondrial electron transport, NADH to ubiquinone, protein lipoylation, proton motive force-driven mitochondrial ATP synthesis; MF: acyl binding, acyl carrier activity, calcium ion binding, fatty acid binding, mitochondrial large ribosomal subunit binding, protein binding, structural molecule activity; CC: iron-sulfur cluster assembly complex, mitochondrial [2Fe-2S] assembly complex, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion, nucleoplasm, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Complex I biogenesis, Diabetic cardiomyopathy - Homo sapiens (human), Electron Transport Chain (OXPHOS system in mitochondria), Fatty acid metabolism, Huntington disease - Homo sapiens (human), Metabolism, Metabolism of lipids, Metabolism of proteins, Mitochondrial Fatty Acid Beta-Oxidation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Non-alcoholic fatty liver disease - Homo sapiens (human), Nonalcoholic fatty liver disease, Oxidative phosphorylation, Oxidative phosphorylation - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Post-translational protein modification, Prion disease - Homo sapiens (human), Protein lipoylation, Respiratory electron transport, Retrograde endocannabinoid signaling - Homo sapiens (human), Thermogenesis - Homo sapiens (human), Translation
UniProt: O14561
Entrez ID: 4706
|
Does Knockout of PPA2 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
PPA2
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: PPA2 (inorganic pyrophosphatase 2)
Type: protein-coding
Summary: The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: diphosphate metabolic process, phosphate-containing compound metabolic process, regulation of mitochondrial membrane potential; MF: hydrolase activity, inorganic diphosphate phosphatase activity, magnesium ion binding, metal ion binding, protein binding, protein serine/threonine phosphatase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion, synapse
Pathways: Oxidative phosphorylation - Homo sapiens (human)
UniProt: Q9H2U2
Entrez ID: 27068
|
Does Knockout of CDC16 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
CDC16
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CDC16 (cell division cycle 16)
Type: protein-coding
Summary: The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, positive regulation of mitotic metaphase/anaphase transition, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; CC: anaphase-promoting complex, centrosome, cytoplasm, cytoskeleton, cytosol, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q13042
Entrez ID: 8881
|
Does Knockout of TGM6 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
TGM6
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: TGM6 (transglutaminase 6)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the transglutaminase superfamily. It catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Mutations in this gene are associated with spinocerebellar ataxia type 35 (SCA35). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
Gene Ontology: MF: acyltransferase activity, metal ion binding, protein-glutamine gamma-glutamyltransferase activity, transferase activity; CC: cytoplasm
Pathways:
UniProt: O95932
Entrez ID: 343641
|
Does Knockout of WWC1 in Renal Cancer Cell Line causally result in cell proliferation?
| 0
| 319
|
Knockout
|
WWC1
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: WWC1 (WW and C2 domain containing 1)
Type: protein-coding
Summary: The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: cell migration, establishment of cell polarity, hippo signaling, negative regulation of cell population proliferation, negative regulation of hippo signaling, negative regulation of organ growth, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of hippo signaling, regulation of DNA-templated transcription, regulation of hippo signaling; MF: kinase binding, molecular adaptor activity, protein binding, signaling adaptor activity, transcription coactivator activity; CC: cell projection, cytoplasm, cytosol, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle membrane
Pathways: Hippo signaling pathway - Homo sapiens (human), Hippo signaling pathway - multiple species - Homo sapiens (human)
UniProt: Q8IX03
Entrez ID: 23286
|
Does Knockout of MLLT10 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,352
|
Knockout
|
MLLT10
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor)
Type: protein-coding
Summary: This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, chromatin binding, histone binding, metal ion binding, nucleosome binding, protein binding, zinc ion binding; CC: nucleoplasm, nucleus, protein-containing complex
Pathways:
UniProt: P55197
Entrez ID: 8028
|
Does Knockout of XAB2 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
XAB2
|
cell proliferation
|
Bladder Carcinoma
|
Gene: XAB2 (XPA binding protein 2)
Type: protein-coding
Summary: Involved in mRNA splicing, via spliceosome; transcription, DNA-templated; and transcription-coupled nucleotide-excision repair. Located in nucleoplasm. Part of U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, RNA processing, RNA splicing, blastocyst development, cerebral cortex development, generation of catalytic spliceosome for first transesterification step, mRNA processing, mRNA splicing, via spliceosome, transcription-coupled nucleotide-excision repair; CC: Prp19 complex, U2-type catalytic step 2 spliceosome, catalytic step 2 spliceosome, membrane, nucleoplasm, nucleus, post-mRNA release spliceosomal complex, spliceosomal complex
Pathways: DNA Repair, Dual incision in TC-NER, Formation of TC-NER Pre-Incision Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Metabolism of RNA, Nucleotide Excision Repair, Processing of Capped Intron-Containing Pre-mRNA, Rett syndrome causing genes, Spliceosome - Homo sapiens (human), Transcription-Coupled Nucleotide Excision Repair (TC-NER), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q9HCS7
Entrez ID: 56949
|
Does Knockout of CADM4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 897
|
Knockout
|
CADM4
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: CADM4 (cell adhesion molecule 4)
Type: protein-coding
Summary: Enables vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of protein phosphorylation; regulation of Rac protein signal transduction; and regulation of wound healing. Located in cell leading edge and cell-cell contact zone. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of peptidyl-threonine phosphorylation, negative regulation of peptidyl-tyrosine phosphorylation, negative regulation of protein phosphorylation, negative regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of vascular endothelial growth factor signaling pathway, regulation of Rac protein signal transduction, regulation of cell motility, regulation of cell population proliferation, regulation of protein phosphorylation, regulation of wound healing; MF: protein binding, protein phosphatase binding, receptor tyrosine kinase binding, vascular endothelial growth factor receptor 1 binding, vascular endothelial growth factor receptor 2 binding; CC: cell leading edge, cell-cell contact zone, membrane
Pathways:
UniProt: Q8NFZ8
Entrez ID: 199731
|
Does Knockout of UBA52 in Neuroblastoma Cell Line causally result in cell proliferation?
| 1
| 824
|
Knockout
|
UBA52
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1)
Type: protein-coding
Summary: Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, modification-dependent protein catabolic process, protein modification process, protein ubiquitination, response to insecticide, translation; MF: protein binding, protein tag activity, structural constituent of ribosome, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endocytic vesicle membrane, endoplasmic reticulum membrane, endosome membrane, extracellular exosome, extracellular space, large ribosomal subunit, lysosomal membrane, mitochondrial outer membrane, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, ribosome, vesicle
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activated NOTCH1 Transmits Signal to the Nucleus, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Aerobic respiration and respiratory electron transport, Aggrephagy, Alpha-protein kinase 1 signaling pathway, Amyloid fiber formation, Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Antiviral mechanism by IFN-stimulated genes, Apoptosis, Asparagine N-linked glycosylation, Assembly Of The HIV Virion, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Autophagy, Axon guidance, Bacterial Infection Pathways, Beta-catenin independent WNT signaling, Budding and maturation of HIV virion, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Calnexin/calreticulin cycle, Cap-dependent Translation Initiation, Cargo recognition for clathrin-mediated endocytosis, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell death signalling via NRAGE, NRIF and NADE, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular response to chemical stress, Cellular response to hypoxia, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Chaperone Mediated Autophagy, Circadian clock, Class I MHC mediated antigen processing & presentation, Clathrin-mediated endocytosis, Co-inhibition by PD-1, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Coronavirus disease - COVID-19 - Homo sapiens (human), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, Cytoplasmic Ribosomal Proteins, Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, Deactivation of the beta-catenin transactivating complex, Death Receptor Signaling, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of carbohydrate metabolism, Diseases of metabolism, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downregulation of ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, Downregulation of ERBB4 signaling, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Downregulation of TGF-beta receptor signaling, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, EGFR downregulation, ER Quality Control Compartment (ERQC), ER-Phagosome pathway, Endosomal Sorting Complex Required For Transport (ESCRT), Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Evasion by RSV of host interferon responses, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, FLT3 Signaling, FLT3 signaling by CBL mutants, FLT3 signaling in disease, Fanconi Anemia Pathway, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, Formation of a pool of free 40S subunits, G1 Phase, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), GTP hydrolysis and joining of the 60S ribosomal subunit, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Glycogen metabolism, Glycogen storage diseases, Glycogen synthesis, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HIV Infection, HIV Life Cycle, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Homology Directed Repair, Host Interactions of HIV factors, IKK complex recruitment mediated by RIP1, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, IRAK2 mediated activation of TAK1 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, ISG15 antiviral mechanism, Immune System, Inactivation of CSF3 (G-CSF) signaling, Infection with Mycobacterium tuberculosis, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, InlA-mediated entry of Listeria monocytogenes into host cells, InlB-mediated entry of Listeria monocytogenes into host cell, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Ion channel transport, Iron uptake and transport, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), L13a-mediated translational silencing of Ceruloplasmin expression, Late Phase of HIV Life Cycle, Late SARS-CoV-2 Infection Events, Late endosomal microautophagy, Listeria monocytogenes entry into host cells, M Phase, MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Macroautophagy, Major pathway of rRNA processing in the nucleolus and cytosol, Maturation of protein E, Membrane Trafficking, Membrane binding and targetting of GAG proteins, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, Metalloprotease DUBs, Mitophagy, Mitophagy - animal - Homo sapiens (human), Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Modulation by Mtb of host immune system, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Myoclonic epilepsy of Lafora, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, NF-kB is activated and signals survival, NIK-->noncanonical NF-kB signaling, NOD1/2 Signaling Pathway, NOTCH1 Intracellular Domain Regulates Transcription, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Neddylation, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of FLT3, Negative regulation of MAPK pathway, Negative regulation of MET activity, Negative regulation of NOTCH4 signaling, Negative regulators of DDX58/IFIH1 signaling, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear events mediated by NFE2L2, Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oncogene Induced Senescence, Orc1 removal from chromatin, Ovarian tumor domain proteases, Oxidative Stress Induced Senescence, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PD-L1(CD274) glycosylation and translocation to plasma membrane, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, PINK1-PRKN Mediated Mitophagy, PIP3 activates AKT signaling, PTEN Regulation, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Peptide chain elongation, Peroxisomal protein import, Pexophagy, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Post-translational protein modification, Prevention of phagosomal-lysosomal fusion, Processing of DNA double-strand break ends, Programmed Cell Death, Protein localization, Protein ubiquitination, Pyruvate metabolism, RAF/MAP kinase cascade, RAS processing, RIPK1-mediated regulated necrosis, RNA Polymerase II Transcription, RSV-host interactions, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Recognition of DNA damage by PCNA-containing replication complex, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulated Necrosis, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of BACH1 activity, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of FZD by ubiquitination, Regulation of Homotypic Cell-Cell Adhesion, Regulation of NF-kappa B signaling, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PLK1 Activity at G2/M Transition, Regulation of PTEN localization, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation, Regulation of TNFR1 signaling, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of innate immune responses to cytosolic DNA, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of necroptotic cell death, Regulation of pyruvate metabolism, Regulation of signaling by CBL, Respiratory Syncytial Virus Infection Pathway, Response of EIF2AK4 (GCN2) to amino acid deficiency, Response of Mtb to phagocytosis, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 activates/modulates innate immune responses, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, SPOP-mediated proteasomal degradation of PD-L1(CD274), SRP-dependent cotranslational protein targeting to membrane, Selective autophagy, Selenoamino acid metabolism, Selenocysteine synthesis, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by CSF1 (M-CSF) in myeloid cells, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by EGFR in Cancer, Signaling by ERBB2, Signaling by ERBB4, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Hedgehog, Signaling by Interleukins, Signaling by Ligand-Responsive EGFR Variants in Cancer, Signaling by MET, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD Domain Mutants in Cancer, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spry regulation of FGF signaling, Stabilization of p53, Stimuli-sensing channels, Suppression of phagosomal maturation, Switching of origins to a post-replicative state, Synthesis And Processing Of GAG, GAGPOL Polyproteins, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, TAK1-dependent IKK and NF-kappa-B activation , TCF dependent signaling in response to WNT, TCR signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), TICAM1, RIP1-mediated IKK complex recruitment, TICAM1,TRAF6-dependent induction of TAK1 complex, TICAM1-dependent activation of IRF3/IRF7, TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , Termination of translesion DNA synthesis, The role of GTSE1 in G2/M progression after G2 checkpoint, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Translation of Structural Proteins, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Homo sapiens (human), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, VLDLR internalisation and degradation, Vesicle-mediated transport, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Viral mRNA Translation, Vpu mediated degradation of CD4, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, activated TAK1 mediates p38 MAPK activation, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, p75 NTR receptor-mediated signalling, p75NTR recruits signalling complexes, p75NTR signals via NF-kB, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62987
Entrez ID: 7311
|
Does Knockout of PPP1CB in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
PPP1CB
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: PPP1CB (protein phosphatase 1 catalytic subunit beta)
Type: protein-coding
Summary: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: MAPK cascade, cell division, circadian regulation of gene expression, entrainment of circadian clock by photoperiod, glycogen metabolic process, protein dephosphorylation, regulation of cell adhesion, regulation of circadian rhythm, rhythmic process; MF: hydrolase activity, metal ion binding, myosin phosphatase activity, myosin-light-chain-phosphatase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein kinase binding, protein serine/threonine phosphatase activity; CC: PTW/PP1 phosphatase complex, chromosome, telomeric region, cytoplasm, cytosol, extracellular exosome, focal adhesion, nucleolus, nucleoplasm, nucleus
Pathways: 22q11.2 copy number variation syndrome, Adrenergic signaling in cardiomyocytes - Homo sapiens (human), Airway smooth muscle cell contraction, Alcoholism - Homo sapiens (human), Amphetamine addiction - Homo sapiens (human), Cell Cycle, Cell Cycle, Mitotic, Cellular senescence - Homo sapiens (human), Circadian clock, Common Pathways Underlying Drug Addiction, Diabetic cardiomyopathy - Homo sapiens (human), Disease, Diseases of signal transduction by growth factor receptors and second messengers, Dopaminergic synapse - Homo sapiens (human), Downregulation of TGF-beta receptor signaling, Focal Adhesion, Focal adhesion - Homo sapiens (human), G13 Signaling Pathway, G2/M Transition, Gain-of-function MRAS complexes activate RAF signaling, Herpes simplex virus 1 infection - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Hippo-Merlin Signaling Dysregulation, Infectious disease, Inflammatory mediator regulation of TRP channels - Homo sapiens (human), Insulin resistance - Homo sapiens (human), Insulin signaling pathway - Homo sapiens (human), Long-term potentiation - Homo sapiens (human), MAPK family signaling cascades, MAPK1/MAPK3 signaling, Maturation of hRSV A proteins, Metabolism, Metabolism of lipids, Mitotic G2-G2/M phases, Oncogenic MAPK signaling, Oocyte meiosis - Homo sapiens (human), Oxytocin signaling pathway - Homo sapiens (human), PLK1 signaling events, Phosphorylation and nuclear translocation of the CRY:PER:kinase complex, Platelet activation - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAF activation, RAF/MAP kinase cascade, RHO GTPase Effectors, RHO GTPases Activate ROCKs, RHO GTPases activate CIT, RHO GTPases activate PAKs, RHO GTPases activate PKNs, Regulation of PLK1 Activity at G2/M Transition, Regulation of actin cytoskeleton - Homo sapiens (human), Respiratory Syncytial Virus Infection Pathway, Respiratory syncytial virus (RSV) genome replication, transcription and translation, SHOC2 M1731 mutant abolishes MRAS complex function, Signal Transduction, Signaling by MRAS-complex mutants, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, TGF-beta receptor signaling activates SMADs, Triglyceride catabolism, Triglyceride metabolism, Vascular smooth muscle contraction - Homo sapiens (human), Viral Infection Pathways, cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: P62140
Entrez ID: 5500
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Does Knockout of PPP1R12A in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
PPP1R12A
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: PPP1R12A (protein phosphatase 1 regulatory subunit 12A)
Type: protein-coding
Summary: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].
Gene Ontology: BP: cellular response to xenobiotic stimulus, centrosome cycle, mitotic cell cycle, negative regulation of catalytic activity, neuron projection morphogenesis, positive regulation of transcription by RNA polymerase II, protein dephosphorylation, regulation of cell adhesion, regulation of establishment of endothelial barrier, regulation of nucleocytoplasmic transport, signal transduction; MF: 14-3-3 protein binding, enzyme inhibitor activity, myosin phosphatase regulator activity, phosphatase regulator activity, protein binding, protein kinase binding; CC: A band, PTW/PP1 phosphatase complex, Z disc, actin cytoskeleton, centrosome, contractile muscle fiber, cytoplasm, cytoskeleton, cytosol, focal adhesion, kinetochore, nucleolus, nucleoplasm, plasma membrane, stress fiber
Pathways: Cell Cycle, Cell Cycle, Mitotic, Focal Adhesion, Focal adhesion - Homo sapiens (human), G2/M Transition, Hippo-Merlin Signaling Dysregulation, Integrin-linked kinase signaling, Mitotic G2-G2/M phases, Oxytocin signaling pathway - Homo sapiens (human), PLK1 signaling events, Platelet activation - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RHO GTPase Effectors, RHO GTPases Activate ROCKs, RHO GTPases activate CIT, RHO GTPases activate PAKs, RHO GTPases activate PKNs, Regulation of Actin Cytoskeleton, Regulation of PLK1 Activity at G2/M Transition, Regulation of actin cytoskeleton - Homo sapiens (human), RhoA signaling pathway, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, TNFalpha, Vascular smooth muscle contraction - Homo sapiens (human), cAMP signaling pathway - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human)
UniProt: O14974
Entrez ID: 4659
|
Does Knockout of SMIM3 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
SMIM3
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SMIM3 (small integral membrane protein 3)
Type: protein-coding
Summary: Enables identical protein binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: identical protein binding, protein binding
Pathways:
UniProt: Q9BZL3
Entrez ID: 85027
|
Does Knockout of ZNHIT6 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
ZNHIT6
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: ZNHIT6 (zinc finger HIT-type containing 6)
Type: protein-coding
Summary: Enables ATPase binding activity; TFIID-class transcription factor complex binding activity; and identical protein binding activity. Involved in box C/D snoRNP assembly; protein complex oligomerization; and snoRNA localization. Located in extracellular exosome. Part of pre-snoRNP complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: box C/D snoRNP assembly, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), protein complex oligomerization, ribosome biogenesis, snoRNA localization; MF: ATPase binding, TFIID-class transcription factor complex binding, enzyme binding, identical protein binding, metal ion binding, protein binding, zinc ion binding; CC: extracellular exosome, nucleus, pre-snoRNP complex
Pathways:
UniProt: Q9NWK9
Entrez ID: 54680
|
Does Knockout of CNPY4 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
CNPY4
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: CNPY4 (canopy FGF signaling regulator 4)
Type: protein-coding
Summary: Predicted to enable signaling receptor binding activity. Involved in positive regulation of protein localization to plasma membrane. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: protein binding, signaling receptor binding
Pathways:
UniProt: Q8N129
Entrez ID: 245812
|
Does Knockout of LSG1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
LSG1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: LSG1 (large 60S subunit nuclear export GTPase 1)
Type: protein-coding
Summary: This gene encodes a protein related to the yeast large subunit GTPase 1. The encoded protein is necessary for cell viability and may localize in the endoplasmic reticulum, nucleus and cytoplasm.[provided by RefSeq, Feb 2009].
Gene Ontology: BP: nuclear export, protein transport, ribosomal subunit export from nucleus; MF: GTP binding, GTPase activity, hydrolase activity, nucleotide binding; CC: Cajal body, cytoplasm, cytosol, endoplasmic reticulum, membrane, nuclear body, nucleoplasm, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q9H089
Entrez ID: 55341
|
Does Knockout of CD180 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
CD180
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: CD180 (CD180 molecule)
Type: protein-coding
Summary: CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell proliferation, B cell proliferation involved in immune response, cellular response to lipopolysaccharide, immune system process, inflammatory response, innate immune response, lipopolysaccharide-mediated signaling pathway, positive regulation of lipopolysaccharide-mediated signaling pathway; MF: lipopolysaccharide immune receptor activity, protein binding, signaling receptor activity; CC: membrane, mitotic spindle, nucleolus, nucleoplasm, plasma membrane
Pathways: Immune System, Innate Immune System, Regulation of toll-like receptor signaling pathway, Toll Like Receptor 4 (TLR4) Cascade, Toll-like Receptor Cascades
UniProt: Q99467
Entrez ID: 4064
|
Does Knockout of NUP205 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
NUP205
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: NUP205 (nucleoporin 205)
Type: protein-coding
Summary: This gene encodes a nucleoporin, which is a subunit of the nuclear pore complex that functions in active transport of proteins, RNAs and ribonucleoprotein particles between the nucleus and cytoplasm. Mutations in this gene are associated with steroid-resistant nephrotic syndrome. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: mRNA transport, nuclear pore complex assembly, nuclear pore organization, nucleocytoplasmic transport, protein transport; MF: protein binding, structural constituent of nuclear pore; CC: cytosol, membrane, nuclear envelope, nuclear membrane, nuclear periphery, nuclear pore, nuclear pore inner ring, nucleus
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Antiviral mechanism by IFN-stimulated genes, Cell Cycle, Cell Cycle, Mitotic, Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC), Disease, Disorders of transmembrane transporters, Export of Viral Ribonucleoproteins from Nucleus, Gene Silencing by RNA, Gene expression (Transcription), Glucose metabolism, Glycolysis, HCMV Early Events, HCMV Infection, HCMV Late Events, HIV Infection, HIV Life Cycle, Host Interactions of HIV factors, IP3 and IP4 transport between cytosol and nucleus, IP6 and IP7 transport between cytosol and nucleus, IPs transport between nucleus and cytosol, ISG15 antiviral mechanism, Immune System, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, Inositol phosphate metabolism, Interactions of Rev with host cellular proteins, Interactions of Vpr with host cellular proteins, Interferon Signaling, Late Phase of HIV Life Cycle, M Phase, Metabolism, Metabolism of RNA, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of non-coding RNA, Metabolism of proteins, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prophase, NEP/NS2 Interacts with the Cellular Export Machinery, NS1 Mediated Effects on Host Pathways, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Nuclear import of Rev protein, Post-translational protein modification, Postmitotic nuclear pore complex (NPC) reformation, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Regulation of Glucokinase by Glucokinase Regulatory Protein, Regulation of HSF1-mediated heat shock response, Rev-mediated nuclear export of HIV RNA, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SLC transporter disorders, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins, SUMOylation of DNA replication proteins, SUMOylation of RNA binding proteins, SUMOylation of SUMOylation proteins, SUMOylation of chromatin organization proteins, SUMOylation of ubiquitinylation proteins, Transcriptional regulation by small RNAs, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of Ribonucleoproteins into the Host Nucleus, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, Viral Infection Pathways, Viral Messenger RNA Synthesis, Vpr-mediated nuclear import of PICs, snRNP Assembly, tRNA processing, tRNA processing in the nucleus
UniProt: Q92621
Entrez ID: 23165
|
Does Knockout of SPTSSA in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
SPTSSA
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: SPTSSA (serine palmitoyltransferase small subunit A)
Type: protein-coding
Summary: Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010].
Gene Ontology: BP: ceramide biosynthetic process, intracellular protein localization, lipid metabolic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingosine biosynthetic process; MF: protein binding, serine C-palmitoyltransferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism, ceramide <i>de novo</i> biosynthesis
UniProt: Q969W0
Entrez ID: 171546
|
Does Knockout of EXPH5 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
EXPH5
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: EXPH5 (exophilin 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the synaptotagmin-like protein (Slp) family lacking a C2 domain. It contains an N-terminal synaptotagmin-like homology domain (SHD), and is a ras-related protein Rab-27B effector protein. This protein is thought to be involved in exosome secretion and intracellular vesicle trafficking. Reduced expression of this gene results in keratin filament defects. Mutations in this gene have been associated with some cases of epidermolysis bullosa, an inherited skin fragility disorder. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
Gene Ontology: BP: intracellular protein transport, keratinocyte development, multivesicular body sorting pathway, positive regulation of exocytosis, positive regulation of protein secretion; MF: small GTPase binding; CC: endosome
Pathways: Deregulation of Rab and Rab Effector Genes in Bladder Cancer
UniProt: Q8NEV8
Entrez ID: 23086
|
Does Knockout of SLC9A7 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
SLC9A7
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: SLC9A7 (solute carrier family 9 member A7)
Type: protein-coding
Summary: This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: monoatomic cation transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport, proton transmembrane transport, regulation of Golgi lumen acidification, regulation of intracellular pH, regulation of pH, sodium ion import across plasma membrane, sodium ion transport, transmembrane transport; MF: antiporter activity, potassium:proton antiporter activity, protein binding, sodium:proton antiporter activity; CC: Golgi apparatus, Golgi membrane, endosome, membrane, plasma membrane, recycling endosome, recycling endosome membrane, trans-Golgi network
Pathways: Cardiac muscle contraction - Homo sapiens (human), Metal ion SLC transporters, SLC-mediated transmembrane transport, Sodium/Proton exchangers, Transport of small molecules
UniProt: Q96T83
Entrez ID: 84679
|
Does Knockout of APOC2 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
APOC2
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: APOC2 (apolipoprotein C2)
Type: protein-coding
Summary: This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011].
Gene Ontology: BP: cholesterol efflux, cholesterol homeostasis, chylomicron remnant clearance, chylomicron remodeling, high-density lipoprotein particle clearance, lipid catabolic process, lipid metabolic process, lipid transport, lipoprotein catabolic process, negative regulation of cholesterol transport, negative regulation of lipid metabolic process, negative regulation of receptor-mediated endocytosis, negative regulation of very-low-density lipoprotein particle clearance, phospholipid efflux, positive regulation of fatty acid biosynthetic process, positive regulation of phospholipid catabolic process, positive regulation of triglyceride catabolic process, positive regulation of very-low-density lipoprotein particle remodeling, reverse cholesterol transport, triglyceride homeostasis, triglyceride-rich lipoprotein particle remodeling, very-low-density lipoprotein particle remodeling; MF: enzyme activator activity, identical protein binding, lipase inhibitor activity, lipid binding, lipoprotein lipase activator activity, molecular function activator activity, phospholipase activator activity, phospholipase binding, protein binding; CC: chylomicron, early endosome, extracellular region, extracellular space, high-density lipoprotein particle, intermediate-density lipoprotein particle, low-density lipoprotein particle, spherical high-density lipoprotein particle, very-low-density lipoprotein particle
Pathways: Assembly of active LPL and LIPC lipase complexes, Cholesterol metabolism - Homo sapiens (human), Chylomicron assembly, Chylomicron remodeling, HDL remodeling, MECP2 and Associated Rett Syndrome, Metabolism, Metabolism of fat-soluble vitamins, Metabolism of vitamins and cofactors, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Plasma lipoprotein assembly, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein remodeling, Retinoid metabolism and transport, Sensory Perception, Signal Transduction, Signaling by Nuclear Receptors, Statin inhibition of cholesterol production, Transport of small molecules, Visual phototransduction
UniProt: P02655
Entrez ID: 344
|
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