prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of DCAF10 in Glioblastoma Cell Line causally result in response to chemicals? | 1 | 2,344 | Knockout | DCAF10 | response to chemicals | Glioblastoma Cell Line | Gene: DCAF10 (DDB1 and CUL4 associated factor 10)
Type: protein-coding
Summary: Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Cul4-RING E3 ubiquitin ligase complex, nucle... |
Does Knockout of SNRPA1 in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | SNRPA1 | cell proliferation | Gastric Cancer Cell Line | Gene: SNRPA1 (small nuclear ribonucleoprotein polypeptide A')
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and spermatogenesis. Located in nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Implicate... |
Does Knockout of TNS4 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | TNS4 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: TNS4 (tensin 4)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: actin binding, protein binding; CC: anchoring junction, cytoplasm,... |
Does Knockout of STK16 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 951 | Knockout | STK16 | cell proliferation | Colonic Cancer Cell Line | Gene: STK16 (serine/threonine kinase 16)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in protein autophosphorylation. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:... |
Does Knockout of SNRPB2 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | SNRPB2 | cell proliferation | Cancer Cell Line | Gene: SNRPB2 (small nuclear ribonucleoprotein polypeptide B2)
Type: protein-coding
Summary: The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies... |
Does Knockout of VPS13C in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | VPS13C | cell proliferation | Astrocytoma Cell Line | Gene: VPS13C (vacuolar protein sorting 13 homolog C)
Type: protein-coding
Summary: This gene encodes a member of the vacuolar protein sorting-associated 13 gene family. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Gene Ontology: BP: Golgi to endosom... |
Does Knockout of TMEM68 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | TMEM68 | cell proliferation | Hepatoma Cell Line | Gene: TMEM68 (transmembrane protein 68)
Type: protein-coding
Summary: Predicted to enable acyltransferase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: lipid metabolic process, triglyceride biosynthetic process;... |
Does Knockout of RPS15 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | RPS15 | cell proliferation | Colorectal Cancer Cell Line | Gene: RPS15 (ribosomal protein S15)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of YRDC in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 427 | Knockout | YRDC | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: YRDC (yrdC N6-threonylcarbamoyltransferase domain containing)
Type: protein-coding
Summary: Predicted to enable nucleotidyltransferase activity and tRNA binding activity. Acts upstream of or within negative regulation of transport. Predicted to be located in membrane and mitochondrion. Predicted t... |
Does Knockout of SAP30BP in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 230 | Knockout | SAP30BP | cell proliferation | Gastric Cancer Cell Line | Gene: SAP30BP (SAP30 binding protein)
Type: protein-coding
Summary: Involved in modulation by host of symbiont transcription; positive regulation of histone deacetylation; and response to virus. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr... |
Does Knockout of TMEM258 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | TMEM258 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: TMEM258 (transmembrane protein 258)
Type: protein-coding
Summary: Involved in protein N-linked glycosylation. Located in endoplasmic reticulum. Part of oligosaccharyltransferase I complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epithelial cell apoptotic pr... |
Does Knockout of CENPM in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | CENPM | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: CENPM (centromere protein M)
Type: protein-coding
Summary: The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associate... |
Does Knockout of C6 in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | C6 | cell proliferation | T-lymphoma cell line | Gene: C6 (complement C6)
Type: protein-coding
Summary: This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component... |
Does Knockout of STC1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | STC1 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: STC1 (stanniocalcin 1)
Type: protein-coding
Summary: This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 co... |
Does Knockout of ACOT9 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | ACOT9 | response to virus | Huh-7 Cell | Gene: ACOT9 (acyl-CoA thioesterase 9)
Type: protein-coding
Summary: The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
Gene Ontology: BP... |
Does Knockout of ZNF438 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | ZNF438 | cell proliferation | Cancer Cell Line | Gene: ZNF438 (zinc finger protein 438)
Type: protein-coding
Summary: Enables DNA-binding transcription factor activity. Involved in negative regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: ne... |
Does Knockout of ATXN7L3 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 519 | Knockout | ATXN7L3 | cell proliferation | Glioblastoma Cell Line | Gene: ATXN7L3 (ataxin 7 like 3)
Type: protein-coding
Summary: Enables nuclear receptor coactivator activity. Involved in histone deubiquitination; histone monoubiquitination; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of DUBm complex and SAGA complex. [provided by ... |
Does Knockout of ZNF207 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | ZNF207 | cell proliferation | Endometrial Cancer Cell Line | Gene: ZNF207 (zinc finger protein 207)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in several processes, including mitotic nuclear division; mitotic spindle assembly checkpoint signaling; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matri... |
Does Knockout of SRP54 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | SRP54 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: SRP54 (signal recognition particle 54)
Type: protein-coding
Summary: Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiat... |
Does Knockout of APIP in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | APIP | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: APIP (APAF1 interacting protein)
Type: protein-coding
Summary: APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]
Gene Ontology: BP: L-methionine salvage from meth... |
Does Knockout of GAPDH in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | GAPDH | cell proliferation | Endometrial Cancer Cell Line | Gene: GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct funct... |
Does Knockout of RPL7A in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | RPL7A | cell proliferation | acute lymphoblastic leukemia cell line | Gene: RPL7A (ribosomal protein L7a)
Type: protein-coding
Summary: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gen... |
Does Knockout of OR51B5 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | OR51B5 | cell proliferation | Medulloblastoma Cell Line | Gene: OR51B5 (olfactory receptor family 51 subfamily B member 5)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of ZBED3 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | ZBED3 | cell proliferation | Glioblastoma Cell Line | Gene: ZBED3 (zinc finger BED-type containing 3)
Type: protein-coding
Summary: This gene belongs to a class of genes that arose through hAT DNA transposition and that encode regulatory proteins. This gene is upregulated in lung cancer tissues, where the encoded protein causes an accumulation of beta-cate... |
Does Knockout of ZNF502 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | ZNF502 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: ZNF502 (zinc finger protein 502)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation by host of viral process. Loc... |
Does Knockout of FASTKD2 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | FASTKD2 | cell proliferation | Breast Cancer Cell Line | Gene: FASTKD2 (FAST kinase domains 2)
Type: protein-coding
Summary: This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by R... |
Does Knockout of PCBP1 in Cancer Cell Line causally result in cell proliferation? | 1 | 1,308 | Knockout | PCBP1 | cell proliferation | Cancer Cell Line | Gene: PCBP1 (poly(rC) binding protein 1)
Type: protein-coding
Summary: This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events ... |
Does Knockout of TMCC1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | TMCC1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: TMCC1 (transmembrane and coiled-coil domain family 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Located in cytosol; endoplasmic reticulum-endosome membrane... |
Does Knockout of TMC6 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | TMC6 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: TMC6 (transmembrane channel like 6)
Type: protein-coding
Summary: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is... |
Does Knockout of HBQ1 in Neuroblastoma Cell Line causally result in cell proliferation? | 0 | 824 | Knockout | HBQ1 | cell proliferation | Neuroblastoma Cell Line | Gene: HBQ1 (hemoglobin subunit theta 1)
Type: protein-coding
Summary: Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member o... |
Does Knockout of RSPO1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | RSPO1 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: RSPO1 (R-spondin 1)
Type: protein-coding
Summary: This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positi... |
Does Knockout of CHTF18 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | CHTF18 | cell proliferation | Cancer Cell Line | Gene: CHTF18 (chromosome transmission fidelity factor 18)
Type: protein-coding
Summary: This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may inte... |
Does Knockout of EXOC7 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | EXOC7 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: EXOC7 (exocyst complex component 7)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encode... |
Does Knockout of DYNLRB1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | DYNLRB1 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: DYNLRB1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated i... |
Does Knockout of TLE3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | TLE3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: TLE3 (TLE family member 3, transcriptional corepressor)
Type: protein-coding
Summary: This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determin... |
Does Knockout of BTLA in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | BTLA | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: BTLA (B and T lymphocyte associated)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing r... |
Does Knockout of TMEM54 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | TMEM54 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: TMEM54 (transmembrane protein 54)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q969K7
Entrez ID: 113452 |
Does Knockout of CLINT1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,736 | Knockout | CLINT1 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: CLINT1 (clathrin interactor 1)
Type: protein-coding
Summary: This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of ... |
Does Knockout of AHCYL2 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | AHCYL2 | cell proliferation | Multiple Myeloma Cell Line | Gene: AHCYL2 (adenosylhomocysteinase like 2)
Type: protein-coding
Summary: The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found f... |
Does Knockout of DDX18 in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | DDX18 | cell proliferation | Monocytic Leukemia Cell Line | Gene: DDX18 (DEAD-box helicase 18)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiatio... |
Does Knockout of C6orf118 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | C6orf118 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: C6orf118 (chromosome 6 open reading frame 118)
Type: protein-coding
Summary: chromosome 6 open reading frame 118
Gene Ontology:
Pathways:
UniProt: Q5T5N4
Entrez ID: 168090 |
Does Knockout of WNK1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | WNK1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: WNK1 (WNK lysine deficient protein kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this g... |
Does Knockout of TAF1B in Renal Cancer Cell Line causally result in cell proliferation? | 1 | 319 | Knockout | TAF1B | cell proliferation | Renal Cancer Cell Line | Gene: TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polym... |
Does Knockout of PPP5C in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | PPP5C | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: PPP5C (protein phosphatase 5 catalytic subunit)
Type: protein-coding
Summary: This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine an... |
Does Knockout of CHTF18 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,658 | Knockout | CHTF18 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: CHTF18 (chromosome transmission fidelity factor 18)
Type: protein-coding
Summary: This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may inte... |
Does Knockout of HES6 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,631 | Knockout | HES6 | response to chemicals | Non-Small Cell Lung Adenocarcinoma Cell Line | Gene: HES6 (hes family bHLH transcription factor 6)
Type: protein-coding
Summary: This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numero... |
Does Knockout of EGF in Embryonic Kidney Cell Line causally result in protein/peptide accumulation? | 0 | 1,461 | Knockout | EGF | protein/peptide accumulation | Embryonic Kidney Cell Line | Gene: EGF (epidermal growth factor)
Type: protein-coding
Summary: This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that ... |
Does Knockout of PLA2G1B in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | PLA2G1B | response to virus | Hepatoma Cell Line | Gene: PLA2G1B (phospholipase A2 group IB)
Type: protein-coding
Summary: This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane gl... |
Does Knockout of TAF1B in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | TAF1B | cell proliferation | Ewing's Sarcoma Cell Line | Gene: TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polym... |
Does Knockout of AKR7A3 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | AKR7A3 | cell proliferation | Cancer Cell Line | Gene: AKR7A3 (aldo-keto reductase family 7 member A3)
Type: protein-coding
Summary: Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: aflatoxin catabolic process, aldehyde metabolic process, respons... |
Does Knockout of PRAMEF1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | PRAMEF1 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: PRAMEF1 (PRAME family member 1)
Type: protein-coding
Summary: This gene is a member of the PRAME (preferentially expressed antigen of melanoma) gene family which is expressed in many cancers but may function in reproductive tissues during development. Alternative promoter usage generates two trans... |
Does Knockout of RPL18 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | RPL18 | cell proliferation | Colonic Cancer Cell Line | Gene: RPL18 (ribosomal protein L18)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encode... |
Does Knockout of APOL3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | APOL3 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: APOL3 (apolipoprotein L3)
Type: protein-coding
Summary: This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholest... |
Does Knockout of CPSF3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | CPSF3 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: CPSF3 (cleavage and polyadenylation specific factor 3)
Type: protein-coding
Summary: This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the p... |
Does Knockout of SNRNP40 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 334 | Knockout | SNRNP40 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: SNRNP40 (small nuclear ribonucleoprotein U5 subunit 40)
Type: protein-coding
Summary: This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger R... |
Does Knockout of FAM220A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | FAM220A | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: FAM220A (family with sequence similarity 220 member A)
Type: protein-coding
Summary: Predicted to enable STAT family protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein dephosphorylation. Predicted to act upstream of or within... |
Does Knockout of EIF3A in Gastric Cancer Cell Line causally result in cell proliferation? | 1 | 787 | Knockout | EIF3A | cell proliferation | Gastric Cancer Cell Line | Gene: EIF3A (eukaryotic translation initiation factor 3 subunit A)
Type: protein-coding
Summary: Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and vi... |
Does Knockout of BCL2L2-PABPN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | BCL2L2-PABPN1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: BCL2L2-PABPN1 (BCL2L2-PABPN1 readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription between the neighboring BCL2L2 (BCL2-like 2) and PABPN1 (poly(A) binding protein, nuclear 1) genes on chromosome 14. The read-through transcript encodes a fu... |
Does Activation of WIPF1 in T cell causally result in protein/peptide accumulation? | 1 | 2,425 | Activation | WIPF1 | protein/peptide accumulation | T cell | Gene: WIPF1 (WAS/WASL interacting protein family member 1)
Type: protein-coding
Summary: This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott... |
Does Knockout of NKAIN2 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | NKAIN2 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: NKAIN2 (sodium/potassium transporting ATPase interacting 2)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that interacts with the beta subunit of a sodium/potassium-transporting ATPase. A chromosomal translocation involving this gene is a cause of lymphoma. Alternative sp... |
Does Knockout of ST8SIA4 in Colorectal Cancer Cell Line causally result in cell proliferation? | 0 | 783 | Knockout | ST8SIA4 | cell proliferation | Colorectal Cancer Cell Line | Gene: ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell ... |
Does Knockout of DCLRE1B in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | DCLRE1B | cell proliferation | Cancer Cell Line | Gene: DCLRE1B (DNA cross-link repair 1B)
Type: protein-coding
Summary: DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-l... |
Does Knockout of OR10S1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | OR10S1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: OR10S1 (olfactory receptor family 10 subfamily S member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-prot... |
Does Knockout of ELOF1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | ELOF1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ELOF1 (elongation factor 1)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in epigenetic maintenance of chromatin in transcription-competent conformation and transcription elongation from RNA polymerase II promoter. Predicted ... |
Does Knockout of CDIPT in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | CDIPT | cell proliferation | Mammary Gland Tumor Cell Line | Gene: CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase)
Type: protein-coding
Summary: Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and pr... |
Does Knockout of PAPLN in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | PAPLN | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PAPLN (papilin, proteoglycan like sulfated glycoprotein)
Type: protein-coding
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix. [pr... |
Does Knockout of ZNF571 in Glioblastoma Cell Line causally result in cell proliferation? | 0 | 906 | Knockout | ZNF571 | cell proliferation | Glioblastoma Cell Line | Gene: ZNF571 (zinc finger protein 571)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RN... |
Does Knockout of FRYL in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | FRYL | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: FRYL (FRY like transcription coactivator)
Type: protein-coding
Summary: Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:... |
Does Knockout of MGST1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 1,813 | Knockout | MGST1 | cell proliferation | Medulloblastoma Cell Line | Gene: MGST1 (microsomal glutathione S-transferase 1)
Type: protein-coding
Summary: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators... |
Does Knockout of NKAP in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | NKAP | cell proliferation | Colorectal Cancer Cell Line | Gene: NKAP (NFKB activating protein)
Type: protein-coding
Summary: This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby act... |
Does Knockout of NMBR in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | NMBR | cell proliferation | Cancer Cell Line | Gene: NMBR (neuromedin B receptor)
Type: protein-coding
Summary: This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth... |
Does Knockout of POLG in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | POLG | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: POLG (DNA polymerase gamma, catalytic subunit)
Type: protein-coding
Summary: Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The enco... |
Does Knockout of SLC24A5 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | SLC24A5 | response to chemicals | Colorectal Cancer Cell Line | Gene: SLC24A5 (solute carrier family 24 member 5)
Type: protein-coding
Summary: This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence v... |
Does Knockout of MIS18BP1 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | MIS18BP1 | cell proliferation | Astrocytoma Cell Line | Gene: MIS18BP1 (MIS18 binding protein 1)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in cell division. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CENP-A containing chromatin... |
Does Knockout of COPS6 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | COPS6 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: COPS6 (COP9 signalosome subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalo... |
Does Knockout of NUF2 in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | NUF2 | cell proliferation | Colorectal Cancer Cell Line | Gene: NUF2 (NUF2 component of NDC80 kinetochore complex)
Type: protein-coding
Summary: This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centr... |
Does Knockout of RNF25 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | RNF25 | cell proliferation | Bladder Carcinoma | Gene: RNF25 (ring finger protein 25)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse ... |
Does Knockout of TP53BP1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 149 | Knockout | TP53BP1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: TP53BP1 (tumor protein p53 binding protein 1)
Type: protein-coding
Summary: This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple role... |
Does Knockout of KRT6A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | KRT6A | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: KRT6A (keratin 6A)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratif... |
Does Knockout of KLF1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 1,789 | Knockout | KLF1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: KLF1 (KLF transcription factor 1)
Type: protein-coding
Summary: This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobi... |
Does Knockout of RTCA in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,996 | Knockout | RTCA | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: RTCA (RNA 3'-terminal phosphate cyclase)
Type: protein-coding
Summary: This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodie... |
Does Knockout of EEF2KMT in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | EEF2KMT | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase)
Type: protein-coding
Summary: Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr ... |
Does Knockout of RNF214 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria? | 1 | 1,480 | Knockout | RNF214 | response to bacteria | Colonic Adenocarcinoma Cell Line | Gene: RNF214 (ring finger protein 214)
Type: protein-coding
Summary: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, ubiquitin-protein trans... |
Does Knockout of PRR12 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | PRR12 | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: PRR12 (proline rich 12)
Type: protein-coding
Summary: This gene encodes a proline-rich protein that contains two A-T hook DNA binding domains. A chromosomal translocation and gene fusion between this gene and zinc finger, MIZ-type containing 1 (Gene ID: 57178) may underlie intellectual disability ... |
Does Knockout of GNGT1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | GNGT1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: GNGT1 (G protein subunit gamma transducin 1)
Type: protein-coding
Summary: This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (gu... |
Does Knockout of UBXN4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | UBXN4 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: UBXN4 (UBX domain protein 4)
Type: protein-coding
Summary: UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM,... |
Does Knockout of RASL11A in Hepatoma Cell Line causally result in response to virus? | 0 | 2,447 | Knockout | RASL11A | response to virus | Hepatoma Cell Line | Gene: RASL11A (RAS like family 11 member A)
Type: protein-coding
Summary: RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]
Gene Ontology: BP: positive regulation of transcription by RNA po... |
Does Knockout of CYB5R3 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,736 | Knockout | CYB5R3 | response to chemicals | Colonic Adenocarcinoma Cell Line | Gene: CYB5R3 (cytochrome b5 reductase 3)
Type: protein-coding
Summary: This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form e... |
Does Activation of CD7 in T cell causally result in protein/peptide accumulation? | 0 | 2,426 | Activation | CD7 | protein/peptide accumulation | T cell | Gene: CD7 (CD7 molecule)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during ear... |
Does Knockout of GAK in Breast Cancer Cell Line causally result in cell proliferation? | 1 | 235 | Knockout | GAK | cell proliferation | Breast Cancer Cell Line | Gene: GAK (cyclin G associated kinase)
Type: protein-coding
Summary: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dep... |
Does Knockout of NXF1 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | NXF1 | cell proliferation | Bladder Carcinoma | Gene: NXF1 (nuclear RNA export factor 1)
Type: protein-coding
Summary: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-li... |
Does Knockout of KIF23 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | KIF23 | cell proliferation | Astrocytoma Cell Line | Gene: KIF23 (kinesin family member 23)
Type: protein-coding
Summary: The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has... |
Does Knockout of GRB2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | GRB2 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: GRB2 (growth factor receptor bound protein 2)
Type: protein-coding
Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its... |
Does Knockout of ERLIN2 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | ERLIN2 | cell proliferation | Cancer Cell Line | Gene: ERLIN2 (ER lipid raft associated 2)
Type: protein-coding
Summary: This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphat... |
Does Knockout of BHLHE22 in Melanoma Cell Line causally result in response to chemicals? | 1 | 1,940 | Knockout | BHLHE22 | response to chemicals | Melanoma Cell Line | Gene: BHLHE22 (basic helix-loop-helix family member e22)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is re... |
Does Knockout of ZNF787 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,033 | Knockout | ZNF787 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: ZNF787 (zinc finger protein 787)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of SNRPA in Glioma Cell Line causally result in protein/peptide accumulation? | 0 | 589 | Knockout | SNRPA | protein/peptide accumulation | Glioma Cell Line | Gene: SNRPA (small nuclear ribonucleoprotein polypeptide A)
Type: protein-coding
Summary: The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregul... |
Does Knockout of MRPS18C in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals? | 0 | 2,222 | Knockout | MRPS18C | response to chemicals | Diffuse Large B-cell Lymphoma Cell | Gene: MRPS18C (mitochondrial ribosomal protein S18C)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subuni... |
Does Knockout of RPF1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | RPF1 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: RPF1 (ribosome production factor 1 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation ... |
Does Knockout of UGGT1 in Gastric Cancer Cell Line causally result in cell proliferation? | 0 | 230 | Knockout | UGGT1 | cell proliferation | Gastric Cancer Cell Line | Gene: UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1)
Type: protein-coding
Summary: UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transpor... |
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