prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of DCAF10 in Glioblastoma Cell Line causally result in response to chemicals?
| 1
| 2,344
|
Knockout
|
DCAF10
|
response to chemicals
|
Glioblastoma Cell Line
|
Gene: DCAF10 (DDB1 and CUL4 associated factor 10)
Type: protein-coding
Summary: Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: Cul4-RING E3 ubiquitin ligase complex, nucleoplasm
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q5QP82
Entrez ID: 79269
|
Does Knockout of SNRPA1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
SNRPA1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SNRPA1 (small nuclear ribonucleoprotein polypeptide A')
Type: protein-coding
Summary: Enables RNA binding activity. Involved in mRNA splicing, via spliceosome and spermatogenesis. Located in nuclear speck. Part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Implicated in connective tissue disease. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, spermatogenesis; MF: RNA binding, U2 snRNA binding, protein binding; CC: U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, nuclear body, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex
Pathways: Cytokine Signaling in Immune system, Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, Immune System, Interleukin-12 family signaling, Interleukin-12 signaling, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Signaling by Interleukins, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, spliceosomal assembly
UniProt: P09661
Entrez ID: 6627
|
Does Knockout of TNS4 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
TNS4
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: TNS4 (tensin 4)
Type: protein-coding
Summary: Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: actin binding, protein binding; CC: anchoring junction, cytoplasm, cytoskeleton, cytosol, focal adhesion
Pathways: EGFR1, Glucocorticoid Receptor Pathway, MET interacts with TNS proteins, MET promotes cell motility, Nuclear Receptors Meta-Pathway, Signal Transduction, Signaling by MET, Signaling by Receptor Tyrosine Kinases
UniProt: Q8IZW8
Entrez ID: 84951
|
Does Knockout of STK16 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 951
|
Knockout
|
STK16
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: STK16 (serine/threonine kinase 16)
Type: protein-coding
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in protein autophosphorylation. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cellular response to transforming growth factor beta stimulus, positive regulation of transcription by RNA polymerase II, protein autophosphorylation; MF: ATP binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, kinase activity, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein tyrosine kinase activity, transferase activity; CC: Golgi apparatus, Golgi-associated vesicle, cytoplasm, cytosol, membrane, nuclear body, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: O75716
Entrez ID: 8576
|
Does Knockout of SNRPB2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
SNRPB2
|
cell proliferation
|
Cancer Cell Line
|
Gene: SNRPB2 (small nuclear ribonucleoprotein polypeptide B2)
Type: protein-coding
Summary: The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, U1 snRNA binding, nucleic acid binding, protein binding; CC: U1 snRNP, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, catalytic step 2 spliceosome, cytoplasmic ribonucleoprotein granule, fibrillar center, nuclear speck, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex, spliceosomal snRNP complex
Pathways: Ciliary landscape, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, spliceosomal assembly
UniProt: P08579
Entrez ID: 6629
|
Does Knockout of VPS13C in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
VPS13C
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: VPS13C (vacuolar protein sorting 13 homolog C)
Type: protein-coding
Summary: This gene encodes a member of the vacuolar protein sorting-associated 13 gene family. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Gene Ontology: BP: Golgi to endosome transport, lipid transport, mitochondrion organization, negative regulation of type 2 mitophagy, protein retention in Golgi apparatus, protein targeting to vacuole, response to insulin; CC: cytoplasm, cytosol, dense core granule membrane, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, extracellular exosome, late endosome, late endosome membrane, lipid droplet, lysosomal membrane, lysosome, membrane, mitochondrial outer membrane, mitochondrion
Pathways:
UniProt: Q709C8
Entrez ID: 54832
|
Does Knockout of TMEM68 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
TMEM68
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: TMEM68 (transmembrane protein 68)
Type: protein-coding
Summary: Predicted to enable acyltransferase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: lipid metabolic process, triglyceride biosynthetic process; MF: acyltransferase activity, phospholipid:diacylglycerol acyltransferase activity, transferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q96MH6
Entrez ID: 137695
|
Does Knockout of RPS15 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
RPS15
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: RPS15 (ribosomal protein S15)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
Gene Ontology: BP: cytoplasmic translation, liver regeneration, osteoblast differentiation, positive regulation of signal transduction by p53 class mediator, rRNA processing, ribosomal small subunit assembly, ribosomal small subunit biogenesis, ribosomal small subunit export from nucleus, translation; MF: DNA binding, MDM2/MDM4 family protein binding, RNA binding, protein binding, structural constituent of ribosome, ubiquitin ligase inhibitor activity; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, focal adhesion, membrane, nucleoplasm, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62841
Entrez ID: 6209
|
Does Knockout of YRDC in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 427
|
Knockout
|
YRDC
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: YRDC (yrdC N6-threonylcarbamoyltransferase domain containing)
Type: protein-coding
Summary: Predicted to enable nucleotidyltransferase activity and tRNA binding activity. Acts upstream of or within negative regulation of transport. Predicted to be located in membrane and mitochondrion. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of transport, regulation of translational fidelity, tRNA threonylcarbamoyladenosine modification; MF: L-threonylcarbamoyladenylate synthase, double-stranded RNA binding, nucleotidyltransferase activity, protein binding, tRNA binding, transferase activity; CC: cytoplasm, membrane, mitochondrion, plasma membrane
Pathways: Metabolism of RNA, tRNA modification in the mitochondrion, tRNA processing
UniProt: Q86U90
Entrez ID: 79693
|
Does Knockout of SAP30BP in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 230
|
Knockout
|
SAP30BP
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: SAP30BP (SAP30 binding protein)
Type: protein-coding
Summary: Involved in modulation by host of symbiont transcription; positive regulation of histone deacetylation; and response to virus. Located in intermediate filament cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, response to virus; CC: intermediate filament cytoskeleton, nucleoplasm, nucleus
Pathways: Epigenetic regulation of gene expression, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression
UniProt: Q9UHR5
Entrez ID: 29115
|
Does Knockout of TMEM258 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
TMEM258
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: TMEM258 (transmembrane protein 258)
Type: protein-coding
Summary: Involved in protein N-linked glycosylation. Located in endoplasmic reticulum. Part of oligosaccharyltransferase I complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: epithelial cell apoptotic process, inflammatory response, protein N-linked glycosylation, protein glycosylation, response to endoplasmic reticulum stress; MF: oligosaccharyltransferase complex binding, protein binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B
Pathways: Adaptive Immune System, Adherens junctions interactions, Asparagine N-linked glycosylation, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Disease, Immune System, Infectious disease, Late SARS-CoV-2 Infection Events, Maturation of spike protein, Metabolism of proteins, PD-L1(CD274) glycosylation and translocation to plasma membrane, Post-translational protein modification, Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, SARS-CoV Infections, SARS-CoV-2 Infection, Translation of Structural Proteins, Viral Infection Pathways
UniProt: P61165
Entrez ID: 746
|
Does Knockout of CENPM in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
CENPM
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: CENPM (centromere protein M)
Type: protein-coding
Summary: The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gene Ontology: CC: chromosome, chromosome, centromeric region, cytoplasm, cytosol, inner kinetochore, kinetochore, nucleoplasm, nucleus
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, Deposition of new CENPA-containing nucleosomes at the centromere, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, Nucleosome assembly, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9NSP4
Entrez ID: 79019
|
Does Knockout of C6 in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
C6
|
cell proliferation
|
T-lymphoma cell line
|
Gene: C6 (complement C6)
Type: protein-coding
Summary: This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012].
Gene Ontology: BP: complement activation, complement activation, GZMK pathway, complement activation, classical pathway, immune response, immune system process, in utero embryonic development, innate immune response, killing of cells of another organism, positive regulation of immune response; CC: extracellular exosome, extracellular region, extracellular space, membrane, membrane attack complex, other organism cell membrane, plasma membrane, transmembrane transporter complex
Pathways: Allograft Rejection, Cells and molecules involved in local acute inflammatory response, Complement Activation, Complement and Coagulation Cascades, Complement and coagulation cascades - Homo sapiens (human), Complement cascade, Complement system, Coronavirus disease - COVID-19 - Homo sapiens (human), Immune System, Innate Immune System, Prion disease - Homo sapiens (human), Regulation of Complement cascade, Systemic lupus erythematosus - Homo sapiens (human), Terminal pathway of complement, alternative complement pathway, classical complement pathway, lectin induced complement pathway
UniProt: P13671
Entrez ID: 729
|
Does Knockout of STC1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
STC1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: STC1 (stanniocalcin 1)
Type: protein-coding
Summary: This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: bone development, cellular response to cAMP, cellular response to glucocorticoid stimulus, cellular response to hypoxia, chondrocyte proliferation, decidualization, embryo implantation, endothelial cell morphogenesis, growth plate cartilage axis specification, intracellular calcium ion homeostasis, negative regulation of calcium ion transport, negative regulation of cell migration, negative regulation of endothelial cell migration, negative regulation of renal phosphate excretion, ossification, positive regulation of calcium ion import, regulation of cardiac muscle cell contraction, regulation of monoatomic anion transport, response to vitamin D, signal transduction; MF: hormone activity, identical protein binding, protein binding; CC: apical plasma membrane, cytoplasm, extracellular region, extracellular space, nucleus
Pathways: Ectoderm Differentiation
UniProt: P52823
Entrez ID: 6781
|
Does Knockout of ACOT9 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
ACOT9
|
response to virus
|
Huh-7 Cell
|
Gene: ACOT9 (acyl-CoA thioesterase 9)
Type: protein-coding
Summary: The protein encoded by this gene is a mitochondrial acyl-CoA thioesterase of unknown function. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010].
Gene Ontology: BP: acyl-CoA metabolic process, fatty acid metabolic process, lipid metabolic process, long-chain fatty acid metabolic process, short-chain fatty acid metabolic process; MF: acetyl-CoA hydrolase activity, carboxylic ester hydrolase activity, fatty acyl-CoA hydrolase activity, hydrolase activity, long-chain fatty acyl-CoA hydrolase activity; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Fatty acid metabolism, Metabolism, Metabolism of lipids, Mitochondrial Fatty Acid Beta-Oxidation, VEGFA-VEGFR2 Signaling Pathway, acyl-CoA hydrolysis
UniProt: Q9Y305
Entrez ID: 23597
|
Does Knockout of ZNF438 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
ZNF438
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZNF438 (zinc finger protein 438)
Type: protein-coding
Summary: Enables DNA-binding transcription factor activity. Involved in negative regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q7Z4V0
Entrez ID: 220929
|
Does Knockout of ATXN7L3 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 519
|
Knockout
|
ATXN7L3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ATXN7L3 (ataxin 7 like 3)
Type: protein-coding
Summary: Enables nuclear receptor coactivator activity. Involved in histone deubiquitination; histone monoubiquitination; and positive regulation of transcription, DNA-templated. Located in nucleus. Part of DUBm complex and SAGA complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: chromatin organization, positive regulation of DNA-templated transcription, regulation of DNA repair, regulation of RNA splicing, regulation of transcription by RNA polymerase II; MF: metal ion binding, protein binding, transcription coactivator activity, zinc ion binding; CC: DUBm complex, SAGA complex, SAGA-type complex, nucleus, transcription factor TFTC complex
Pathways: Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones
UniProt: Q14CW9
Entrez ID: 56970
|
Does Knockout of ZNF207 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
ZNF207
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ZNF207 (zinc finger protein 207)
Type: protein-coding
Summary: Enables microtubule binding activity. Involved in several processes, including mitotic nuclear division; mitotic spindle assembly checkpoint signaling; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, microtubule bundle formation, microtubule polymerization, mitotic sister chromatid segregation, mitotic spindle assembly, mitotic spindle assembly checkpoint signaling, protein stabilization, regulation of chromosome segregation; MF: DNA binding, RNA binding, heparin binding, metal ion binding, microtubule binding, protein binding, zinc ion binding; CC: chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, kinetochore, microtubule, nucleolus, nucleoplasm, nucleus, spindle, spindle matrix
Pathways:
UniProt: O43670
Entrez ID: 7756
|
Does Knockout of SRP54 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
SRP54
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: SRP54 (signal recognition particle 54)
Type: protein-coding
Summary: Enables several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Contributes to GTPase activity. Involved in granulocyte differentiation and protein targeting to ER. Located in cytosol and nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. Implicated in severe congenital neutropenia 8. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: SRP-dependent cotranslational protein targeting to membrane, SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition, SRP-dependent cotranslational protein targeting to membrane, translocation, exocrine pancreas development, granulocyte differentiation, neutrophil chemotaxis, protein targeting to ER; MF: 7S RNA binding, GDP binding, GTP binding, GTPase activity, RNA binding, endoplasmic reticulum signal peptide binding, hydrolase activity, nucleotide binding, protein binding, ribonucleoprotein complex binding; CC: cytoplasm, cytosol, endoplasmic reticulum, nuclear speck, nucleolus, nucleus, ribonucleoprotein complex, signal recognition particle, signal recognition particle, endoplasmic reticulum targeting
Pathways: Metabolism of proteins, Protein export - Homo sapiens (human), SRP-dependent cotranslational protein targeting to membrane, Translation, VEGFA-VEGFR2 Signaling Pathway, mRNA Processing
UniProt: P61011
Entrez ID: 6729
|
Does Knockout of APIP in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
APIP
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: APIP (APAF1 interacting protein)
Type: protein-coding
Summary: APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008]
Gene Ontology: BP: L-methionine salvage from methylthioadenosine, amino acid biosynthetic process, apoptotic process, methionine biosynthetic process, negative regulation of apoptotic process, protein homotetramerization, pyroptotic inflammatory response, regulation of ERK1 and ERK2 cascade; MF: identical protein binding, lyase activity, metal ion binding, methylthioribulose 1-phosphate dehydratase activity, protein binding, zinc ion binding; CC: cytoplasm, cytosol
Pathways: <i>S</i>-methyl-5-thio-α-D-ribose 1-phosphate degradation, Cysteine and methionine metabolism - Homo sapiens (human), Methionine De Novo and Salvage Pathway
UniProt: Q96GX9
Entrez ID: 51074
|
Does Knockout of GAPDH in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
GAPDH
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: GAPDH (glyceraldehyde-3-phosphate dehydrogenase)
Type: protein-coding
Summary: This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, apoptotic process, cellular response to type II interferon, defense response to fungus, glucose metabolic process, glycolytic process, immune system process, innate immune response, killing by host of symbiont cells, killing of cells of another organism, microtubule cytoskeleton organization, negative regulation of endopeptidase activity, negative regulation of translation, neuron apoptotic process, peptidyl-cysteine S-trans-nitrosylation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cytokine production, positive regulation of type I interferon production, protein stabilization, regulation of macroautophagy, regulation of translation; MF: NAD binding, NADP binding, aspartic-type endopeptidase inhibitor activity, disordered domain specific binding, glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity, identical protein binding, microtubule binding, oxidoreductase activity, oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, peptidyl-cysteine S-nitrosylase activity, protein binding, transferase activity; CC: GAIT complex, cytoplasm, cytoskeleton, cytosol, extracellular exosome, lipid droplet, membrane, microtubule cytoskeleton, nuclear membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, ribonucleoprotein complex, vesicle
Pathways: Alzheimer disease - Homo sapiens (human), Alzheimer,s disease, Computational Model of Aerobic Glycolysis, Cori Cycle, Diabetic cardiomyopathy - Homo sapiens (human), Fanconi-bickel syndrome, Fructose-1,6-diphosphatase deficiency, Gluconeogenesis, Glucose metabolism, Glycerol Phosphate Shuttle, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type VII. Tarui disease, Glycolysis, Glycolysis / Gluconeogenesis - Homo sapiens (human), Glycolysis and Gluconeogenesis, Glycolysis in senescence, HIF-1 signaling pathway - Homo sapiens (human), HIF1A and PPARG regulation of glycolysis, Metabolic reprogramming in colon cancer, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Mitochondrial Electron Transport Chain, NADH repair, Pathogenic Escherichia coli infection - Homo sapiens (human), Pathways in clear cell renal cell carcinoma, Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Salmonella infection - Homo sapiens (human), Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Triosephosphate isomerase, VEGFA-VEGFR2 Signaling Pathway, Validated targets of C-MYC transcriptional activation, Warburg Effect, downregulated of mta-3 in er-negative breast tumors, gluconeogenesis, glycolysis, superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
UniProt: P04406
Entrez ID: 2597
|
Does Knockout of RPL7A in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
RPL7A
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: RPL7A (ribosomal protein L7a)
Type: protein-coding
Summary: Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, maturation of LSU-rRNA, ribosome biogenesis, translation; MF: RNA binding, cadherin binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, focal adhesion, membrane, nucleolus, nucleus, ribonucleoprotein complex, ribosome, synapse
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62424
Entrez ID: 6130
|
Does Knockout of OR51B5 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
OR51B5
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: OR51B5 (olfactory receptor family 51 subfamily B member 5)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cellular response to lipid, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction, system process; MF: G protein-coupled receptor activity, olfactory receptor activity, signaling receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q9H339
Entrez ID: 282763
|
Does Knockout of ZBED3 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
ZBED3
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ZBED3 (zinc finger BED-type containing 3)
Type: protein-coding
Summary: This gene belongs to a class of genes that arose through hAT DNA transposition and that encode regulatory proteins. This gene is upregulated in lung cancer tissues, where the encoded protein causes an accumulation of beta-catenin and enhanced lung cancer cell invasion. In addition, the encoded protein can be secreted and be involved in resistance to insulin. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: Wnt signaling pathway, actin filament organization, endoplasmic reticulum localization, establishment of spindle localization, mitochondrion localization, negative regulation of protein phosphorylation, positive regulation of canonical Wnt signaling pathway, positive regulation of embryonic development, positive regulation of transcription by RNA polymerase II, protein stabilization, regulation of transcription by RNA polymerase II, response to glucose, response to insulin; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding; CC: chromatin, cytoplasm, cytosol, extracellular region, extracellular space, membrane
Pathways:
UniProt: Q96IU2
Entrez ID: 84327
|
Does Knockout of ZNF502 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
ZNF502
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ZNF502 (zinc finger protein 502)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation by host of viral process. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: host-mediated activation of viral process, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, viral release from host cell; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q8TBZ5
Entrez ID: 91392
|
Does Knockout of FASTKD2 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
FASTKD2
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: FASTKD2 (FAST kinase domains 2)
Type: protein-coding
Summary: This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008].
Gene Ontology: BP: RNA processing, apoptotic process, mitochondrial RNA processing, mitochondrial large ribosomal subunit assembly, mitochondrial translation, positive regulation of mitochondrial translation, regulation of mitochondrial mRNA stability, ribosome biogenesis; MF: RNA binding, protein binding, rRNA binding; CC: mitochondrial matrix, mitochondrial nucleoid, mitochondrion, ribonucleoprotein granule
Pathways: FASTK family proteins regulate processing and stability of mitochondrial RNAs, Metabolism of RNA, Mitochondrial RNA degradation, Mitochondrial mRNA modification, rRNA modification in the mitochondrion, rRNA processing, rRNA processing in the mitochondrion
UniProt: Q9NYY8
Entrez ID: 22868
|
Does Knockout of PCBP1 in Cancer Cell Line causally result in cell proliferation?
| 1
| 1,308
|
Knockout
|
PCBP1
|
cell proliferation
|
Cancer Cell Line
|
Gene: PCBP1 (poly(rC) binding protein 1)
Type: protein-coding
Summary: This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, viral RNA genome replication; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA binding, cadherin binding, mRNA binding, nucleic acid binding, protein binding, sequence-specific single stranded DNA binding, single-stranded DNA binding; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, extracellular exosome, membrane, nuclear speck, nucleoplasm, nucleus, postsynaptic density, ribonucleoprotein complex
Pathways: Ferroptosis, Ferroptosis - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q15365
Entrez ID: 5093
|
Does Knockout of TMCC1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
TMCC1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: TMCC1 (transmembrane and coiled-coil domain family 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: endoplasmic reticulum organization, endosomal transport, endosome fission, endosome membrane tubulation, membrane fission; MF: identical protein binding, protein binding; CC: cytosol, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-endosome membrane contact site, membrane, rough endoplasmic reticulum
Pathways:
UniProt: O94876
Entrez ID: 23023
|
Does Knockout of TMC6 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
TMC6
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: TMC6 (transmembrane channel like 6)
Type: protein-coding
Summary: Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: intracellular zinc ion homeostasis, monoatomic ion transmembrane transport, protein stabilization; MF: mechanosensitive monoatomic ion channel activity, protein binding; CC: Golgi apparatus, Golgi membrane, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, membrane, nuclear membrane, nucleus, plasma membrane, specific granule membrane, tertiary granule membrane
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q7Z403
Entrez ID: 11322
|
Does Knockout of HBQ1 in Neuroblastoma Cell Line causally result in cell proliferation?
| 0
| 824
|
Knockout
|
HBQ1
|
cell proliferation
|
Neuroblastoma Cell Line
|
Gene: HBQ1 (hemoglobin subunit theta 1)
Type: protein-coding
Summary: Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-2 -pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: erythrocyte development, oxygen transport; MF: heme binding, iron ion binding, metal ion binding, oxygen binding, oxygen carrier activity, protein binding; CC: haptoglobin-hemoglobin complex, hemoglobin complex
Pathways:
UniProt: P09105
Entrez ID: 3049
|
Does Knockout of RSPO1 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
RSPO1
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: RSPO1 (R-spondin 1)
Type: protein-coding
Summary: This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Gene Ontology: BP: Wnt signaling pathway, positive regulation of Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway, positive regulation of protein phosphorylation, regulation of macromolecule metabolic process, regulation of receptor internalization; MF: G protein-coupled receptor binding, heparin binding, protein binding, signaling receptor binding; CC: extracellular region, extracellular space, nucleus
Pathways: Mammalian disorder of sexual development, Regulation of FZD by ubiquitination, Signal Transduction, Signaling by WNT, Somatic sex determination, TCF dependent signaling in response to WNT, Wnt, Wnt signaling network, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q2MKA7
Entrez ID: 284654
|
Does Knockout of CHTF18 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
CHTF18
|
cell proliferation
|
Cancer Cell Line
|
Gene: CHTF18 (chromosome transmission fidelity factor 18)
Type: protein-coding
Summary: This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, chromosome, cytoplasm, cytosol, membrane, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Gastric Cancer Network 2, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance
UniProt: Q8WVB6
Entrez ID: 63922
|
Does Knockout of EXOC7 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
EXOC7
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: EXOC7 (exocyst complex component 7)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011].
Gene Ontology: BP: exocytosis, membrane fission, mitotic cytokinesis, positive regulation of mitotic cytokinetic process, protein transmembrane transport, protein transport, regulation of entry of bacterium into host cell, regulation of macroautophagy, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; MF: phosphatidylinositol-4,5-bisphosphate binding, protein binding, protein-macromolecule adaptor activity; CC: Flemming body, centriolar satellite, cytoplasm, cytosol, exocyst, growth cone membrane, membrane, microtubule organizing center, midbody, plasma membrane
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, Arf6 trafficking events, CDC42 signaling events, Ciliary landscape, Insulin Pathway, Insulin signaling pathway - Homo sapiens (human), Salmonella infection - Homo sapiens (human)
UniProt: Q9UPT5
Entrez ID: 23265
|
Does Knockout of DYNLRB1 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
DYNLRB1
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: DYNLRB1 (dynein light chain roadblock-type 1)
Type: protein-coding
Summary: This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: microtubule-based movement, positive regulation of intracellular transport, visual behavior; MF: dynein intermediate chain binding, identical protein binding, microtubule motor activity, protein binding; CC: centrosome, ciliary tip, cilium, cytoplasm, cytoplasmic dynein complex, cytoskeleton, dynein complex, membrane, microtubule
Pathways: 3q29 copy number variation syndrome, Ciliary landscape, Cilium Assembly, Intraflagellar transport, Intraflagellar transport proteins binding to dynein, Organelle biogenesis and maintenance, Salmonella infection - Homo sapiens (human), TGF-beta receptor signaling, TGF_beta_Receptor
UniProt: Q9NP97
Entrez ID: 83658
|
Does Knockout of TLE3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
TLE3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TLE3 (TLE family member 3, transcriptional corepressor)
Type: protein-coding
Summary: This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: Wnt signaling pathway, animal organ morphogenesis, negative regulation of DNA-templated transcription, negative regulation of canonical Wnt signaling pathway, negative regulation of cold-induced thermogenesis, regulation of DNA-templated transcription, signal transduction; MF: protein binding, transcription corepressor activity; CC: beta-catenin-TCF complex, nucleoplasm, nucleus, transcription regulator complex
Pathways: Notch signaling pathway - Homo sapiens (human), White fat cell differentiation, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q04726
Entrez ID: 7090
|
Does Knockout of BTLA in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
BTLA
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: BTLA (B and T lymphocyte associated)
Type: protein-coding
Summary: This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: adaptive immune response, immune response-regulating cell surface receptor signaling pathway, immune system process, negative regulation of T cell proliferation; MF: protein binding, signaling receptor activity; CC: membrane, plasma membrane
Pathways: Adaptive Immune System, BCR, Co-inhibition by BTLA, Immune System, Regulation of T cell activation by CD28 family, Vitamin D Receptor Pathway
UniProt: Q7Z6A9
Entrez ID: 151888
|
Does Knockout of TMEM54 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
TMEM54
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TMEM54 (transmembrane protein 54)
Type: protein-coding
Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology:
Pathways:
UniProt: Q969K7
Entrez ID: 113452
|
Does Knockout of CLINT1 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,736
|
Knockout
|
CLINT1
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: CLINT1 (clathrin interactor 1)
Type: protein-coding
Summary: This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: clathrin coat assembly, endocytosis; MF: cadherin binding, clathrin binding, lipid binding, phospholipid binding, protein binding; CC: Golgi apparatus, clathrin vesicle coat, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, endomembrane system, endosome, membrane, nucleoplasm, perinuclear region of cytoplasm, plasma membrane
Pathways: Fibroblast growth factor-1, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: Q14677
Entrez ID: 9685
|
Does Knockout of AHCYL2 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
AHCYL2
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: AHCYL2 (adenosylhomocysteinase like 2)
Type: protein-coding
Summary: The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
Gene Ontology: BP: S-adenosylmethionine cycle, one-carbon metabolic process; MF: adenosylhomocysteinase activity, hydrolase activity, protein binding; CC: cytoplasm, cytosol, endoplasmic reticulum, intracellular membrane-bounded organelle, neuron projection
Pathways: Bicarbonate transporters, Cysteine and methionine metabolism - Homo sapiens (human), One-carbon metabolism, SLC-mediated transmembrane transport, SLC-mediated transport of inorganic anions, Trans-sulfuration and one-carbon metabolism, Transport of small molecules, cysteine biosynthesis, methionine degradation, superpathway of methionine degradation
UniProt: Q96HN2
Entrez ID: 23382
|
Does Knockout of DDX18 in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
DDX18
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: DDX18 (DEAD-box helicase 18)
Type: protein-coding
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to estradiol stimulus, maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: chromosome, membrane, nucleolus, nucleus
Pathways: Validated targets of C-MYC transcriptional activation
UniProt: Q9NVP1
Entrez ID: 8886
|
Does Knockout of C6orf118 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
C6orf118
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: C6orf118 (chromosome 6 open reading frame 118)
Type: protein-coding
Summary: chromosome 6 open reading frame 118
Gene Ontology:
Pathways:
UniProt: Q5T5N4
Entrez ID: 168090
|
Does Knockout of WNK1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
WNK1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: WNK1 (WNK lysine deficient protein kinase 1)
Type: protein-coding
Summary: This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010].
Gene Ontology: BP: DNA damage response, T cell receptor signaling pathway, cell volume homeostasis, cellular hyperosmotic response, cellular response to chemokine, chemokine (C-C motif) ligand 21 signaling pathway, heart development, homeostatic process, intracellular chloride ion homeostasis, intracellular signal transduction, lymphocyte migration into lymph node, membraneless organelle assembly, monoatomic cation homeostasis, monoatomic ion transport, negative regulation of autophagy, negative regulation of cell-cell adhesion mediated by integrin, negative regulation of heterotypic cell-cell adhesion, negative regulation of leukocyte cell-cell adhesion, negative regulation of pancreatic juice secretion, negative regulation of protein localization to plasma membrane, negative regulation of protein ubiquitination, negative regulation of small GTPase mediated signal transduction, negative regulation of sodium ion transport, neuron development, positive regulation of T cell chemotaxis, positive regulation of angiogenesis, positive regulation of canonical Wnt signaling pathway, positive regulation of mitotic cytokinesis, positive regulation of systemic arterial blood pressure, positive regulation of termination of RNA polymerase II transcription, potassium ion homeostasis, potassium ion transmembrane transport, protein insertion into ER membrane by stop-transfer membrane-anchor sequence, protein phosphorylation, regulation of blood pressure, regulation of mRNA export from nucleus, regulation of monoatomic cation transmembrane transport, regulation of sodium ion transmembrane transport, regulation of sodium ion transport, signal transduction, sodium ion transmembrane transport; MF: ATP binding, kinase activity, molecular condensate scaffold activity, nucleotide binding, phosphatase binding, protein binding, protein kinase activator activity, protein kinase activity, protein kinase binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytoskeleton, cytosol, intracellular membraneless organelle, membrane, mitotic spindle, nucleus, protein-containing complex, spindle
Pathways: Ciliary landscape, Ion channel transport, Stimuli-sensing channels, Transport of small molecules
UniProt: Q9H4A3
Entrez ID: 65125
|
Does Knockout of TAF1B in Renal Cancer Cell Line causally result in cell proliferation?
| 1
| 319
|
Knockout
|
TAF1B
|
cell proliferation
|
Renal Cancer Cell Line
|
Gene: TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: DNA-templated transcription, RNA polymerase I preinitiation complex assembly, nucleolar large rRNA transcription by RNA polymerase I, transcription by RNA polymerase I; MF: DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, TBP-class protein binding, metal ion binding, protein binding, zinc ion binding; CC: RNA polymerase I core factor complex, RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, Rett syndrome causing genes, SIRT1 negatively regulates rRNA expression
UniProt: Q53T94
Entrez ID: 9014
|
Does Knockout of PPP5C in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
PPP5C
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: PPP5C (protein phosphatase 5 catalytic subunit)
Type: protein-coding
Summary: This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, MAPK cascade, cellular response to cadmium ion, cellular response to hydrogen peroxide, double-strand break repair, mitotic cell cycle, negative regulation of MAPK cascade, negative regulation of apoptotic process, peptidyl-serine dephosphorylation, positive regulation of canonical NF-kappaB signal transduction, positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway, response to arachidonate, response to lead ion, response to morphine; MF: ADP binding, ATP binding, G-protein alpha-subunit binding, Hsp70 protein binding, Hsp90 protein binding, RNA binding, heat shock protein binding, hydrolase activity, identical protein binding, lipid binding, metal ion binding, microtubule binding, mitogen-activated protein kinase kinase kinase binding, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine kinase inhibitor activity, protein serine/threonine phosphatase activity, protein-containing complex binding, tau protein binding; CC: cytoplasm, cytosol, membrane, neuronal cell body, nucleoplasm, nucleus, perikaryon, plasma membrane, protein folding chaperone complex, protein-containing complex, proximal dendrite
Pathways: ATM Signaling Network in Development and Disease, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, ESR-mediated signaling, ErbB1 downstream signaling, Glucocorticoid receptor regulatory network, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, Negative regulation of MAPK pathway, RAF/MAP kinase cascade, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Signal Transduction, Signaling by Nuclear Receptors
UniProt: P53041
Entrez ID: 5536
|
Does Knockout of CHTF18 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,658
|
Knockout
|
CHTF18
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: CHTF18 (chromosome transmission fidelity factor 18)
Type: protein-coding
Summary: This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, nucleotide binding, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, chromosome, cytoplasm, cytosol, membrane, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Gastric Cancer Network 2, Polymerase switching on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance
UniProt: Q8WVB6
Entrez ID: 63922
|
Does Knockout of HES6 in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,631
|
Knockout
|
HES6
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: HES6 (hes family bHLH transcription factor 6)
Type: protein-coding
Summary: This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008].
Gene Ontology: BP: anterior/posterior pattern specification, cell differentiation, negative regulation of transcription by RNA polymerase II, nervous system development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of neurogenesis, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, protein binding, protein dimerization activity, sequence-specific double-stranded DNA binding, transcription regulator inhibitor activity; CC: chromatin, nucleus, transcription regulator complex
Pathways: Human papillomavirus infection - Homo sapiens (human), Notch, Notch Signaling Pathway Netpath, Notch-mediated HES/HEY network, Osteoblast differentiation
UniProt: Q96HZ4
Entrez ID: 55502
|
Does Knockout of EGF in Embryonic Kidney Cell Line causally result in protein/peptide accumulation?
| 0
| 1,461
|
Knockout
|
EGF
|
protein/peptide accumulation
|
Embryonic Kidney Cell Line
|
Gene: EGF (epidermal growth factor)
Type: protein-coding
Summary: This gene encodes a member of the epidermal growth factor superfamily. The encoded preproprotein is proteolytically processed to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding with high affinity to the cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: ERBB2-EGFR signaling pathway, ERK1 and ERK2 cascade, angiogenesis, branching morphogenesis of an epithelial tube, cell population proliferation, cerebellar granule cell precursor proliferation, epidermal growth factor receptor signaling pathway, epithelial cell proliferation, mammary gland alveolus development, negative regulation of cholesterol efflux, negative regulation of secretion, positive regulation of DNA binding, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of canonical Wnt signaling pathway, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cerebellar granule cell precursor proliferation, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of epithelial tube formation, positive regulation of gene expression, positive regulation of hyaluronan biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of mitotic nuclear division, positive regulation of peptidyl-threonine phosphorylation, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of phosphorylation, positive regulation of protein localization to early endosome, positive regulation of receptor internalization, positive regulation of ubiquitin-dependent protein catabolic process, regulation of calcium ion import, regulation of primary metabolic process, regulation of protein localization to cell surface, regulation of receptor signaling pathway via JAK-STAT, regulation of transport, system development; MF: calcium ion binding, epidermal growth factor receptor binding, growth factor activity, guanyl-nucleotide exchange factor activity, protein binding, receptor ligand activity, transmembrane receptor protein tyrosine kinase activator activity; CC: clathrin-coated endocytic vesicle membrane, extracellular exosome, extracellular region, extracellular space, lysosomal membrane, membrane, plasma membrane, platelet alpha granule lumen
Pathways: Arf6 signaling events, Bladder cancer, Bladder cancer - Homo sapiens (human), Breast cancer - Homo sapiens (human), Breast cancer pathway, Calcium signaling pathway - Homo sapiens (human), Cardiac Hypertrophic Response, Cargo recognition for clathrin-mediated endocytosis, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Ceramide signaling pathway, Choline metabolism in cancer - Homo sapiens (human), Clathrin-mediated endocytosis, Colorectal cancer - Homo sapiens (human), Constitutive Signaling by Aberrant PI3K in Cancer, Constitutive Signaling by EGFRvIII, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Cell Lineages of the Integumentary System, Developmental Lineage of Mammary Gland Luminal Epithelial Cells, Developmental Lineage of Mammary Gland Myoepithelial Cells, Developmental Lineage of Multipotent Pancreatic Progenitor Cells, Developmental Lineages of the Mammary Gland, Differentiation Pathway, Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downregulation of ERBB2 signaling, EGF-EGFR signaling pathway, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR downregulation, EGFR interacts with phospholipase C-gamma, EGFR-dependent Endothelin signaling events, EGFR1, ERBB2 Activates PTK6 Signaling, ERBB2 Regulates Cell Motility, ERK Pathway in Huntington,s Disease, ESC Pluripotency Pathways, ESR-mediated signaling, Endometrial cancer, Endometrial cancer - Homo sapiens (human), ErbB receptor signaling network, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), ErbB1 downstream signaling, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Extra-nuclear estrogen signaling, Extracellular vesicles in the crosstalk of cardiac cells, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), FoxO signaling pathway - Homo sapiens (human), GAB1 signalosome, GRB2 events in EGFR signaling, GRB2 events in ERBB2 signaling, Gap junction - Homo sapiens (human), Gastric cancer - Homo sapiens (human), Glioma - Homo sapiens (human), HIF-1 signaling pathway - Homo sapiens (human), Hemostasis, Hepatitis C - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Inhibition of Signaling by Overexpressed EGFR, Internalization of ErbB1, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Homo sapiens (human), KEAP1-NFE2L2 pathway, Lung fibrosis, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, Mammary gland development pathway - Puberty (Stage 2 of 4), Melanoma - Homo sapiens (human), Membrane Trafficking, MicroRNAs in cardiomyocyte hypertrophy, NFE2L2 regulating tumorigenic genes, NOTCH3 Activation and Transmission of Signal to the Nucleus, Negative regulation of the PI3K/AKT network, Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Nuclear events mediated by NFE2L2, PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human), PI3K events in ERBB2 signaling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, PLCG1 events in ERBB2 signaling, Pancreatic adenocarcinoma pathway, Pancreatic cancer - Homo sapiens (human), Pathways in cancer - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet degranulation , Posttranslational regulation of adherens junction stability and dissassembly, Prostate cancer - Homo sapiens (human), RAF/MAP kinase cascade, Rap1 signaling pathway - Homo sapiens (human), Ras signaling pathway - Homo sapiens (human), Regulation of Actin Cytoskeleton, Regulation of Telomerase, Regulation of actin cytoskeleton - Homo sapiens (human), Response to elevated platelet cytosolic Ca2+, SHC1 events in EGFR signaling, SHC1 events in ERBB2 signaling, SHP2 signaling, Signal Transduction, Signaling by EGFR, Signaling by EGFR in Cancer, Signaling by EGFRvIII in Cancer, Signaling by ERBB2, Signaling by ERBB2 ECD mutants, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 TMD/JMD mutants, Signaling by ERBB2 in Cancer, Signaling by ERBB4, Signaling by Ligand-Responsive EGFR Variants in Cancer, Signaling by NOTCH, Signaling by NOTCH3, Signaling by Non-Receptor Tyrosine Kinases, Signaling by Nuclear Receptors, Signaling by Overexpressed Wild-Type EGFR in Cancer, Signaling by PTK6, Signaling by Receptor Tyrosine Kinases, Signaling events mediated by PTP1B, Signaling events mediated by TCPTP, Stabilization and expansion of the E-cadherin adherens junction, TGF-beta Receptor Signaling, TGF-beta receptor signaling in skeletal dysplasias, Thromboxane A2 receptor signaling, Vesicle-mediated transport, a6b1 and a6b4 Integrin signaling, cbl mediated ligand-induced downregulation of egf receptors pathway, egf signaling pathway, keratinocyte differentiation, map kinase inactivation of smrt corepressor, mcalpain and friends in cell motility, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, sprouty regulation of tyrosine kinase signals
UniProt: P01133
Entrez ID: 1950
|
Does Knockout of PLA2G1B in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
PLA2G1B
|
response to virus
|
Hepatoma Cell Line
|
Gene: PLA2G1B (phospholipase A2 group IB)
Type: protein-coding
Summary: This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: actin filament organization, antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, arachidonate secretion, cellular response to insulin stimulus, defense response to Gram-positive bacterium, fatty acid biosynthetic process, innate immune response in mucosa, intracellular signal transduction, leukotriene biosynthetic process, lipid catabolic process, lipid metabolic process, neutrophil chemotaxis, neutrophil mediated immunity, phosphatidylcholine metabolic process, phosphatidylglycerol metabolic process, phospholipid metabolic process, positive regulation of MAPK cascade, positive regulation of calcium ion transport into cytosol, positive regulation of cell population proliferation, positive regulation of fibroblast proliferation, positive regulation of immune response, positive regulation of interleukin-8 production, positive regulation of podocyte apoptotic process, positive regulation of protein secretion, positive regulation of transcription by RNA polymerase II, regulation of D-glucose import, signal transduction; MF: bile acid binding, calcium ion binding, calcium-dependent phospholipase A2 activity, hydrolase activity, metal ion binding, phospholipase A2 activity, phospholipid binding, signaling receptor binding; CC: cell surface, extracellular region, extracellular space
Pathways: Acyl chain remodelling of PC, Acyl chain remodelling of PE, Acyl chain remodelling of PG, Acyl chain remodelling of PI, Acyl chain remodelling of PS, Arachidonic acid metabolism - Homo sapiens (human), Developmental Biology, Developmental Cell Lineages, Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Pancreatic Acinar Cells, Ether lipid metabolism - Homo sapiens (human), Fat digestion and absorption - Homo sapiens (human), Fc-epsilon receptor I signaling in mast cells, Glycerolipids and Glycerophospholipids, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Linoleic acid metabolism - Homo sapiens (human), Metabolism, Metabolism of lipids, Pancreatic secretion - Homo sapiens (human), Phospholipid metabolism, Ras signaling, Ras signaling pathway - Homo sapiens (human), Synthesis of PA, Vascular smooth muscle contraction - Homo sapiens (human), alpha-Linolenic acid metabolism - Homo sapiens (human), eicosanoid metabolism, fc epsilon receptor i signaling in mast cells, p38 mapk signaling pathway, phospholipases
UniProt: P04054
Entrez ID: 5319
|
Does Knockout of TAF1B in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
TAF1B
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B)
Type: protein-coding
Summary: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
Gene Ontology: BP: DNA-templated transcription, RNA polymerase I preinitiation complex assembly, nucleolar large rRNA transcription by RNA polymerase I, transcription by RNA polymerase I; MF: DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, TBP-class protein binding, metal ion binding, protein binding, zinc ion binding; CC: RNA polymerase I core factor complex, RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, Rett syndrome causing genes, SIRT1 negatively regulates rRNA expression
UniProt: Q53T94
Entrez ID: 9014
|
Does Knockout of AKR7A3 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
AKR7A3
|
cell proliferation
|
Cancer Cell Line
|
Gene: AKR7A3 (aldo-keto reductase family 7 member A3)
Type: protein-coding
Summary: Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: aflatoxin catabolic process, aldehyde metabolic process, response to toxic substance; MF: NADP+ binding, alcohol dehydrogenase (NADP+) activity, electron transfer activity, identical protein binding, oxidoreductase activity, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, extracellular exosome
Pathways: Aflatoxin B1 metabolism, Aflatoxin activation and detoxification, Biological oxidations, Metabolism, Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human), Metapathway biotransformation Phase I and II
UniProt: O95154
Entrez ID: 22977
|
Does Knockout of PRAMEF1 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
PRAMEF1
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: PRAMEF1 (PRAME family member 1)
Type: protein-coding
Summary: This gene is a member of the PRAME (preferentially expressed antigen of melanoma) gene family which is expressed in many cancers but may function in reproductive tissues during development. Alternative promoter usage generates two transcript variants, which encode different isoforms. [provided by RefSeq, Jun 2014].
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of cell differentiation, positive regulation of cell population proliferation, proteasome-mediated ubiquitin-dependent protein catabolic process; MF: ubiquitin-like ligase-substrate adaptor activity; CC: Cul2-RING ubiquitin ligase complex, cytoplasm
Pathways:
UniProt: O95521
Entrez ID: 65121
|
Does Knockout of RPL18 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
RPL18
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: RPL18 (ribosomal protein L18)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: cytoplasmic translation, translation; MF: RNA binding, protein binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endoplasmic reticulum, focal adhesion, membrane, nucleolus, nucleus, ribonucleoprotein complex, ribosome, rough endoplasmic reticulum
Pathways: Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q07020
Entrez ID: 6141
|
Does Knockout of APOL3 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
APOL3
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: APOL3 (apolipoprotein L3)
Type: protein-coding
Summary: This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
Gene Ontology: BP: inflammatory response, lipid transport, lipoprotein metabolic process, positive regulation of canonical NF-kappaB signal transduction; MF: lipid binding, lipid transporter activity, protein binding; CC: cytoplasm, extracellular region, membrane
Pathways:
UniProt: O95236
Entrez ID: 80833
|
Does Knockout of CPSF3 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
CPSF3
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: CPSF3 (cleavage and polyadenylation specific factor 3)
Type: protein-coding
Summary: This gene encodes a member of the metallo-beta-lactamase family. The encoded protein is a 73kDa subunit of the cleavage and polyadenylation specificity factor and functions as an endonuclease that recognizes the pre-mRNA 3'-cleavage site AAUAAA prior to polyadenylation. It also cleaves after the pre-mRNA sequence ACCCA during histone 3'-end pre-mRNA processing. [provided by RefSeq, Oct 2012].
Gene Ontology: BP: co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA 3'-end processing by stem-loop binding and cleavage, mRNA processing, positive regulation of G1/S transition of mitotic cell cycle; MF: 5'-3' RNA exonuclease activity, RNA binding, RNA endonuclease activity, endonuclease activity, hydrolase activity, metal ion binding, nuclease activity, protein binding; CC: mRNA cleavage and polyadenylation specificity factor complex, nucleoplasm, nucleus, ribonucleoprotein complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, Processing of Intronless Pre-mRNAs, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, mRNA 3'-end processing, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human), polyadenylation of mrna
UniProt: Q9UKF6
Entrez ID: 51692
|
Does Knockout of SNRNP40 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 334
|
Knockout
|
SNRNP40
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: SNRNP40 (small nuclear ribonucleoprotein U5 subunit 40)
Type: protein-coding
Summary: This gene encodes a component of the U5 small nuclear ribonucleoprotein (snRNP) particle. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA processing, RNA splicing, RNA splicing, via transesterification reactions, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, protein binding; CC: U2-type catalytic step 2 spliceosome, U4/U6 x U5 tri-snRNP complex, U5 snRNP, catalytic step 2 spliceosome, cytosol, nuclear speck, nucleoplasm, nucleus, sno(s)RNA-containing ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: Q96DI7
Entrez ID: 9410
|
Does Knockout of FAM220A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
FAM220A
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: FAM220A (family with sequence similarity 220 member A)
Type: protein-coding
Summary: Predicted to enable STAT family protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein dephosphorylation. Predicted to act upstream of or within positive regulation of protein binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: STAT family protein binding, protein binding; CC: acrosomal vesicle, cytoplasm, cytoplasmic vesicle, nucleus
Pathways:
UniProt: Q7Z4H9
Entrez ID: 84792
|
Does Knockout of EIF3A in Gastric Cancer Cell Line causally result in cell proliferation?
| 1
| 787
|
Knockout
|
EIF3A
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: EIF3A (eukaryotic translation initiation factor 3 subunit A)
Type: protein-coding
Summary: Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: IRES-dependent viral translational initiation, cytoplasmic translational initiation, formation of cytoplasmic translation initiation complex, negative regulation of ERK1 and ERK2 cascade, translation, translation reinitiation, translational initiation, viral translational termination-reinitiation; MF: RNA binding, mRNA binding, protein binding, receptor tyrosine kinase binding, structural molecule activity, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic 43S preinitiation complex, eukaryotic 48S preinitiation complex, eukaryotic translation initiation factor 3 complex, eukaryotic translation initiation factor 3 complex, eIF3e, eukaryotic translation initiation factor 3 complex, eIF3m, membrane, microtubule, multi-eIF complex, nucleolus, nucleoplasm, organelle, postsynaptic density, protein-containing complex
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, IL2 signaling events mediated by PI3K, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, RNA transport - Homo sapiens (human), Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, eukaryotic protein translation, internal ribosome entry pathway, mtor signaling pathway, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell
UniProt: Q14152
Entrez ID: 8661
|
Does Knockout of BCL2L2-PABPN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
BCL2L2-PABPN1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: BCL2L2-PABPN1 (BCL2L2-PABPN1 readthrough)
Type: protein-coding
Summary: This locus represents naturally occurring read-through transcription between the neighboring BCL2L2 (BCL2-like 2) and PABPN1 (poly(A) binding protein, nuclear 1) genes on chromosome 14. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010].
Gene Ontology:
Pathways: Direct p53 effectors, Influenza A - Homo sapiens (human), mRNA surveillance pathway - Homo sapiens (human)
UniProt: A0A7I2V383
Entrez ID: 100529063
|
Does Activation of WIPF1 in T cell causally result in protein/peptide accumulation?
| 1
| 2,425
|
Activation
|
WIPF1
|
protein/peptide accumulation
|
T cell
|
Gene: WIPF1 (WAS/WASL interacting protein family member 1)
Type: protein-coding
Summary: This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: actin filament-based movement, actin filament-based process, actin polymerization or depolymerization, protein folding, protein-containing complex assembly, response to other organism; MF: SH3 domain binding, actin binding, cytoskeletal anchor activity, profilin binding, protein binding, protein folding chaperone; CC: actin cytoskeleton, actin filament, cell projection, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, ruffle
Pathways: Endocytosis - Homo sapiens (human), Fc-epsilon receptor I signaling in mast cells, KitReceptor, Pathogenic Escherichia coli infection - Homo sapiens (human), TCR, Yersinia infection - Homo sapiens (human)
UniProt: O43516
Entrez ID: 7456
|
Does Knockout of NKAIN2 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
NKAIN2
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: NKAIN2 (sodium/potassium transporting ATPase interacting 2)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that interacts with the beta subunit of a sodium/potassium-transporting ATPase. A chromosomal translocation involving this gene is a cause of lymphoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014].
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q5VXU1
Entrez ID: 154215
|
Does Knockout of ST8SIA4 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 0
| 783
|
Knockout
|
ST8SIA4
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: ST8SIA4 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: N-glycan processing, ganglioside biosynthetic process, nervous system development, oligosaccharide metabolic process, protein glycosylation, protein modification process, sialylation; MF: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity, glycosyltransferase activity, sialic acid binding, sialyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, extracellular region, membrane
Pathways: Asparagine N-linked glycosylation, Axon guidance, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Developmental Biology, Ectoderm Differentiation, Metabolism of proteins, NCAM signaling for neurite out-growth, NCAM1 interactions, Nervous system development, Post-translational protein modification, Sialic acid metabolism, Synthesis of substrates in N-glycan biosythesis
UniProt: Q92187
Entrez ID: 7903
|
Does Knockout of DCLRE1B in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
DCLRE1B
|
cell proliferation
|
Cancer Cell Line
|
Gene: DCLRE1B (DNA cross-link repair 1B)
Type: protein-coding
Summary: DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: DNA damage response, DNA repair, double-strand break repair via nonhomologous end joining, interstrand cross-link repair, protection from non-homologous end joining at telomere, telomere capping, telomere maintenance, telomere maintenance via telomere lengthening, telomeric 3' overhang formation, telomeric loop formation; MF: 5'-3' DNA exonuclease activity, 5'-3' exonuclease activity, beta-lactamase activity, damaged DNA binding, exonuclease activity, hydrolase activity, nuclease activity, protein binding, protein homodimerization activity, protein-containing complex binding; CC: centrosome, chromosome, chromosome, telomeric region, cytoplasm, cytoskeleton, nuclear body, nucleoplasm, nucleus
Pathways: DNA Repair, Fanconi Anemia Pathway
UniProt: Q9H816
Entrez ID: 64858
|
Does Knockout of OR10S1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
OR10S1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: OR10S1 (olfactory receptor family 10 subfamily S member 1)
Type: protein-coding
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of smell, sensory perception of smell, signal transduction; MF: G protein-coupled receptor activity, olfactory receptor activity; CC: membrane, plasma membrane
Pathways: Expression and translocation of olfactory receptors, Olfactory Signaling Pathway, Olfactory transduction - Homo sapiens (human), Sensory Perception
UniProt: Q8NGN2
Entrez ID: 219873
|
Does Knockout of ELOF1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
ELOF1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ELOF1 (elongation factor 1)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in epigenetic maintenance of chromatin in transcription-competent conformation and transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, transcription elongation by RNA polymerase II, transcription-coupled nucleotide-excision repair; MF: RNA polymerase II complex binding, protein binding, protein-macromolecule adaptor activity; CC: chromosome, nucleus, transcription elongation factor complex
Pathways:
UniProt: P60002
Entrez ID: 84337
|
Does Knockout of CDIPT in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
CDIPT
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase)
Type: protein-coding
Summary: Phosphatidylinositol breakdown products are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. Two enzymes, CDP-diacylglycerol synthase and phosphatidylinositol synthase, are involved in the biosynthesis of phosphatidylinositol. Phosphatidylinositol synthase, a member of the CDP-alcohol phosphatidyl transferase class-I family, is an integral membrane protein found on the cytoplasmic side of the endoplasmic reticulum and the Golgi apparatus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013].
Gene Ontology: BP: CDP-diacylglycerol metabolic process, lipid metabolic process, phosphatidylinositol biosynthetic process, phospholipid biosynthetic process; MF: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity, alcohol binding, carbohydrate binding, diacylglycerol binding, manganese ion binding, metal ion binding, phosphotransferase activity, for other substituted phosphate groups, protein binding, transferase activity; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: 16p11.2 proximal deletion syndrome, 3-phosphoinositide biosynthesis, D-<i>myo</i>-inositol (1,4,5)-trisphosphate biosynthesis, Glycerolipids and Glycerophospholipids, Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Homo sapiens (human), Inositol phosphate metabolism - Homo sapiens (human), Joubert syndrome, Metabolism, Metabolism of lipids, Phosphatidylinositol Phosphate Metabolism, Phosphatidylinositol signaling system - Homo sapiens (human), Phospholipid Biosynthesis, Phospholipid metabolism, Synthesis of PI, superpathway of inositol phosphate compounds
UniProt: O14735
Entrez ID: 10423
|
Does Knockout of PAPLN in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
PAPLN
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PAPLN (papilin, proteoglycan like sulfated glycoprotein)
Type: protein-coding
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to be located in basement membrane. Predicted to be active in extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: basement membrane, extracellular region
Pathways:
UniProt: O95428
Entrez ID: 89932
|
Does Knockout of ZNF571 in Glioblastoma Cell Line causally result in cell proliferation?
| 0
| 906
|
Knockout
|
ZNF571
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: ZNF571 (zinc finger protein 571)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q7Z3V5
Entrez ID: 51276
|
Does Knockout of FRYL in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
FRYL
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: FRYL (FRY like transcription coactivator)
Type: protein-coding
Summary: Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: cell morphogenesis, neuron projection development; CC: cell cortex, site of polarized growth
Pathways:
UniProt: O94915
Entrez ID: 285527
|
Does Knockout of MGST1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 1,813
|
Knockout
|
MGST1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: MGST1 (microsomal glutathione S-transferase 1)
Type: protein-coding
Summary: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: cellular oxidant detoxification, cellular response to lipid hydroperoxide, glutathione transport; MF: glutathione peroxidase activity, glutathione transferase activity, protein binding, transferase activity; CC: azurophil granule membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion, peroxisomal membrane, plasma membrane
Pathways: Aflatoxin activation and detoxification, Aryl Hydrocarbon Receptor Pathway, Biological oxidations, Chemical carcinogenesis - Homo sapiens (human), Drug metabolism - cytochrome P450 - Homo sapiens (human), Drug metabolism - other enzymes - Homo sapiens (human), Fluid shear stress and atherosclerosis - Homo sapiens (human), Glutathione conjugation, Glutathione metabolism - Homo sapiens (human), Hepatocellular carcinoma - Homo sapiens (human), Immune System, Innate Immune System, Metabolism, Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human), Metapathway biotransformation Phase I and II, Neutrophil degranulation, Nuclear Receptors Meta-Pathway, Oxidative Stress, Pathways in cancer - Homo sapiens (human), Phase II - Conjugation of compounds, glutathione-mediated detoxification
UniProt: P10620
Entrez ID: 4257
|
Does Knockout of NKAP in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
NKAP
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: NKAP (NFKB activating protein)
Type: protein-coding
Summary: This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010].
Gene Ontology: BP: Notch signaling pathway, T cell differentiation in thymus, granulocyte differentiation, hematopoietic stem cell proliferation, hemopoiesis, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of alpha-beta T cell differentiation, somatic stem cell population maintenance; MF: RNA binding, chromatin DNA binding, chromatin binding, protein binding; CC: cytosol, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q8N5F7
Entrez ID: 79576
|
Does Knockout of NMBR in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
NMBR
|
cell proliferation
|
Cancer Cell Line
|
Gene: NMBR (neuromedin B receptor)
Type: protein-coding
Summary: This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, antiviral innate immune response, bombesin receptor signaling pathway, negative regulation of interleukin-6 production, neuropeptide signaling pathway, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of interferon-alpha production, positive regulation of osteoclast proliferation, positive regulation of respiratory gaseous exchange, signal transduction, sneeze reflex; MF: G protein-coupled peptide receptor activity, G protein-coupled receptor activity, bombesin receptor activity, neuropeptide receptor activity; CC: cytosol, membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, GPCRs, Class A Rhodopsin-like, Neuroactive ligand-receptor interaction - Homo sapiens (human), Peptide GPCRs, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: P28336
Entrez ID: 4829
|
Does Knockout of POLG in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
POLG
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: POLG (DNA polymerase gamma, catalytic subunit)
Type: protein-coding
Summary: Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA biosynthetic process, DNA metabolic process, DNA repair, DNA replication, DNA replication proofreading, DNA-templated DNA replication, base-excision repair, base-excision repair, gap-filling, mitochondrial DNA replication; MF: 3'-5' exonuclease activity, 5'-deoxyribose-5-phosphate lyase activity, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, catalytic activity, acting on a nucleic acid, chromatin binding, hydrolase activity, lyase activity, nucleotidyltransferase activity, protease binding, protein binding, single-stranded DNA 3'-5' DNA exonuclease activity, transferase activity; CC: gamma DNA polymerase complex, mitochondrial chromosome, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, protein-containing complex
Pathways: DNA Replication, Male infertility, Nucleotide metabolism, Strand-asynchronous mitochondrial DNA replication
UniProt: P54098
Entrez ID: 5428
|
Does Knockout of SLC24A5 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
SLC24A5
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: SLC24A5 (solute carrier family 24 member 5)
Type: protein-coding
Summary: This gene is a member of the potassium-dependent sodium/calcium exchanger family and encodes an intracellular membrane protein with 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments. Sequence variation in this gene has been associated with differences in skin pigmentation. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: calcium ion import, calcium ion transmembrane transport, calcium ion transport, intracellular calcium ion homeostasis, melanin biosynthetic process, monoatomic ion transmembrane transport, monoatomic ion transport, negative regulation of melanin biosynthetic process, potassium ion transmembrane transport, potassium ion transport, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: antiporter activity, calcium channel activity, calcium ion transmembrane transporter activity, calcium, potassium:sodium antiporter activity, protein binding, symporter activity; CC: Golgi apparatus, melanosome, membrane, trans-Golgi network, trans-Golgi network membrane
Pathways: Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6), Disease, Disorders of transmembrane transporters, Metal ion SLC transporters, SLC transporter disorders, SLC-mediated transmembrane transport, Sodium/Calcium exchangers, Transport of small molecules
UniProt: Q71RS6
Entrez ID: 283652
|
Does Knockout of MIS18BP1 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
MIS18BP1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: MIS18BP1 (MIS18 binding protein 1)
Type: protein-coding
Summary: Predicted to enable DNA binding activity. Predicted to be involved in cell division. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: CENP-A containing chromatin assembly, cell division, pericentric heterochromatin organization; MF: DNA binding, protein binding; CC: CENP-A recruiting complex, chromosome, chromosome, centromeric region, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle, Mitotic, Chromosome Maintenance, Cyclin A/B1/B2 associated events during G2/M transition, Deposition of new CENPA-containing nucleosomes at the centromere, G2/M Transition, Mitotic G2-G2/M phases, Nucleosome assembly
UniProt: Q6P0N0
Entrez ID: 55320
|
Does Knockout of COPS6 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
COPS6
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: COPS6 (COP9 signalosome subunit 6)
Type: protein-coding
Summary: The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: protein deneddylation, protein neddylation, regulation of protein neddylation; MF: metal-dependent deubiquitinase activity, peptidase activity, protein binding; CC: COP9 signalosome, cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Cargo recognition for clathrin-mediated endocytosis, Ciliary landscape, Clathrin-mediated endocytosis, DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, Global Genome Nucleotide Excision Repair (GG-NER), Membrane Trafficking, Metabolism of proteins, Neddylation, Nucleotide Excision Repair, Nucleotide-binding Oligomerization Domain (NOD) pathway, Post-translational protein modification, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Vesicle-mediated transport
UniProt: Q7L5N1
Entrez ID: 10980
|
Does Knockout of NUF2 in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
NUF2
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: NUF2 (NUF2 component of NDC80 kinetochore complex)
Type: protein-coding
Summary: This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore organization, meiotic chromosome segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization; MF: microtubule binding, protein binding, protein-containing complex binding; CC: Ndc80 complex, chromosome, chromosome, centromeric region, cytosol, kinetochore, membrane, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9BZD4
Entrez ID: 83540
|
Does Knockout of RNF25 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
RNF25
|
cell proliferation
|
Bladder Carcinoma
|
Gene: RNF25 (ring finger protein 25)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: positive regulation of NF-kappaB transcription factor activity, protein K6-linked ubiquitination, protein ubiquitination, protein-RNA covalent cross-linking repair, rescue of stalled ribosome, translational elongation, translational termination, ubiquitin-dependent protein catabolic process; MF: NF-kappaB binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytosol, cytosolic ribosome, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, TNFalpha
UniProt: Q96BH1
Entrez ID: 64320
|
Does Knockout of TP53BP1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 149
|
Knockout
|
TP53BP1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: TP53BP1 (tumor protein p53 binding protein 1)
Type: protein-coding
Summary: This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017].
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, DNA repair, DNA strand resection involved in replication fork processing, cellular response to X-ray, chromatin organization, chromatin remodeling, double-strand break repair, double-strand break repair via classical nonhomologous end joining, double-strand break repair via nonhomologous end joining, negative regulation of DNA strand resection involved in replication fork processing, negative regulation of double-strand break repair via homologous recombination, positive regulation of DNA-templated transcription, positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, positive regulation of isotype switching, positive regulation of transcription by RNA polymerase II, protein homooligomerization, protein localization to site of double-strand break, regulation of DNA-templated transcription; MF: DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, damaged DNA binding, histone H4K20me methyltransferase activity, histone H4K20me2 reader activity, histone binding, histone reader activity, p53 binding, protein binding, sequence-specific DNA binding, telomeric DNA binding, transcription coactivator activity, transcription coregulator activity, ubiquitin-modified histone reader activity; CC: DNA repair complex, chromosome, chromosome, centromeric region, chromosome, telomeric region, cytoplasm, kinetochore, nuclear body, nucleoplasm, nucleus, replication fork, site of double-strand break
Pathways: ATM Signaling Network in Development and Disease, ATM Signaling Pathway, ATM pathway, NOD-like receptor signaling pathway - Homo sapiens (human)
UniProt: Q12888
Entrez ID: 7158
|
Does Knockout of KRT6A in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
KRT6A
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KRT6A (keratin 6A)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, cell differentiation, defense response to Gram-positive bacterium, intermediate filament organization, keratinization, killing of cells of another organism, morphogenesis of an epithelium, negative regulation of entry of bacterium into host cell, positive regulation of cell population proliferation, wound healing; MF: protein binding, structural constituent of cytoskeleton, structural constituent of skin epidermis; CC: cytosol, extracellular exosome, intermediate filament, keratin filament, membrane, nucleus
Pathways: Developmental Biology, EGFR1, Ectoderm Differentiation, Formation of the cornified envelope, Keratinization
UniProt: P02538
Entrez ID: 3853
|
Does Knockout of KLF1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 1,789
|
Knockout
|
KLF1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: KLF1 (KLF transcription factor 1)
Type: protein-coding
Summary: This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: cellular response to endothelin, erythrocyte differentiation, maternal process involved in female pregnancy, positive regulation of DNA-templated transcription, protein destabilization, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, ubiquitin-dependent protein catabolic process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, transcription cis-regulatory region binding, ubiquitin binding, zinc ion binding; CC: chromatin, nucleoplasm, nucleus
Pathways:
UniProt: Q13351
Entrez ID: 10661
|
Does Knockout of RTCA in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,996
|
Knockout
|
RTCA
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: RTCA (RNA 3'-terminal phosphate cyclase)
Type: protein-coding
Summary: This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: RNA processing, negative regulation of optical nerve axon regeneration; MF: ATP binding, RNA binding, RNA-3'-phosphate cyclase activity, catalytic activity, ligase activity, nucleotide binding, protein binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: O00442
Entrez ID: 8634
|
Does Knockout of EEF2KMT in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
EEF2KMT
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: EEF2KMT (eukaryotic elongation factor 2 lysine methyltransferase)
Type: protein-coding
Summary: Enables protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine trimethylation. Located in cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: methylation, peptidyl-lysine trimethylation; MF: methyltransferase activity, protein binding, protein-lysine N-methyltransferase activity, transferase activity; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Metabolism of proteins, Post-translational protein modification, Protein methylation
UniProt: Q96G04
Entrez ID: 196483
|
Does Knockout of RNF214 in Colonic Adenocarcinoma Cell Line causally result in response to bacteria?
| 1
| 1,480
|
Knockout
|
RNF214
|
response to bacteria
|
Colonic Adenocarcinoma Cell Line
|
Gene: RNF214 (ring finger protein 214)
Type: protein-coding
Summary: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: metal ion binding, ubiquitin-protein transferase activity, zinc ion binding
Pathways:
UniProt: Q8ND24
Entrez ID: 257160
|
Does Knockout of PRR12 in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
PRR12
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: PRR12 (proline rich 12)
Type: protein-coding
Summary: This gene encodes a proline-rich protein that contains two A-T hook DNA binding domains. A chromosomal translocation and gene fusion between this gene and zinc finger, MIZ-type containing 1 (Gene ID: 57178) may underlie intellectual disability and neuropsychiatric problems in a human patient. Enriched expression of this gene in embryonic mouse brain suggests that this gene may play a role in nervous system development. [provided by RefSeq, Jul 2016].
Gene Ontology: CC: neuron projection, nucleus, postsynaptic density, synapse
Pathways:
UniProt: Q9ULL5
Entrez ID: 57479
|
Does Knockout of GNGT1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
GNGT1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GNGT1 (G protein subunit gamma transducin 1)
Type: protein-coding
Summary: This gene encodes the gamma subunit of transducin, a guanine nucleotide-binding protein (G protein) that is found in rod outer segments. Transducin, also known as GMPase, mediates the activation of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase by rhodopsin. [provided by RefSeq, Jul 2016].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, cardiac muscle cell apoptotic process, cellular response to hypoxia, eye photoreceptor cell development, intracellular protein localization, phototransduction, signal transduction; MF: G-protein beta-subunit binding, GTPase activity, protein binding; CC: heterotrimeric G-protein complex, membrane, photoreceptor disc membrane, photoreceptor inner segment, photoreceptor outer segment, plasma membrane
Pathways: -arrestins in gpcr desensitization, ADORA2B mediated anti-inflammatory cytokines production, ADP signalling through P2Y purinoceptor 1, ADP signalling through P2Y purinoceptor 12, Activation of G protein gated Potassium channels, Activation of GABAB receptors, Activation of kainate receptors upon glutamate binding, Activation of the phototransduction cascade, Adrenaline,noradrenaline inhibits insulin secretion, Alcoholism - Homo sapiens (human), Anti-inflammatory response favouring Leishmania parasite infection, Apelin signaling pathway - Homo sapiens (human), Aquaporin-mediated transport, Beta-catenin independent WNT signaling, Ca2+ pathway, Calcium Regulation in the Cardiac Cell, Cellular responses to mechanical stimuli, Cellular responses to stimuli, Chaperonin-mediated protein folding, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Cholinergic synapse - Homo sapiens (human), Circadian entrainment - Homo sapiens (human), Class B/2 (Secretin family receptors), Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Disease, Dopaminergic synapse - Homo sapiens (human), ESR-mediated signaling, Estrogen signaling pathway, Extra-nuclear estrogen signaling, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, G Protein Signaling Pathways, G alpha (12/13) signalling events, G alpha (i) signalling events, G alpha (q) signalling events, G alpha (s) signalling events, G alpha (z) signalling events, G beta:gamma signalling through BTK, G beta:gamma signalling through CDC42, G beta:gamma signalling through PI3Kgamma, G beta:gamma signalling through PLC beta, G protein gated Potassium channels, G-protein activation, G-protein beta:gamma signalling, GABA B receptor activation, GABA receptor activation, GABAergic synapse - Homo sapiens (human), GPCR downstream signalling, GPCR ligand binding, GPER1 signaling, Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, Glucagon-type ligand receptors, Glutamatergic synapse - Homo sapiens (human), Hemostasis, High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells, Human cytomegalovirus infection - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Inactivation, recovery and regulation of the phototransduction cascade, Infectious disease, Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, Integration of energy metabolism, Inwardly rectifying K+ channels, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), Leishmania infection, Leishmania parasite growth and survival, Metabolism, Metabolism of proteins, Morphine addiction - Homo sapiens (human), Myometrial relaxation and contraction pathways, Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Opioid Signalling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), Parasitic Infection Pathways, Pathways in cancer - Homo sapiens (human), Phototransduction - Homo sapiens (human), Platelet activation, signaling and aggregation, Platelet homeostasis, Potassium Channels, Presynaptic function of Kainate receptors, Prostacyclin signalling through prostacyclin receptor, Protein folding, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of insulin secretion, Relaxin signaling pathway - Homo sapiens (human), Response of endothelial cells to shear stress, Retrograde endocannabinoid signaling - Homo sapiens (human), Sensory Perception, Serotonergic synapse - Homo sapiens (human), Signal Transduction, Signal amplification, Signaling by GPCR, Signaling by Nuclear Receptors, Signaling by WNT, The phototransduction cascade, Thrombin signalling through proteinase activated receptors (PARs), Thromboxane signalling through TP receptor, Transmission across Chemical Synapses, Transport of small molecules, Vasopressin regulates renal water homeostasis via Aquaporins, Visual phototransduction, Visual signal transduction: Rods, actions of nitric oxide in the heart, activation of camp-dependent protein kinase pka, activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor, aspirin blocks signaling pathway involved in platelet activation, attenuation of gpcr signaling, bioactive peptide induced signaling pathway, ccr3 signaling in eosinophils, chrebp regulation by carbohydrates and camp, corticosteroids and cardioprotection, cxcr4 signaling pathway, cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway, fmlp induced chemokine gene expression in hmc-1 cells, g-protein signaling through tubby proteins, how progesterone initiates the oocyte maturation, ion channels and their functional role in vascular endothelium, phospholipids as signalling intermediaries, pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase, regulation of ck1/cdk5 by type 1 glutamate receptors, regulation of spermatogenesis by crem, role of -arrestins in the activation and targeting of map kinases, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, roles of arrestin dependent recruitment of src kinases in gpcr signaling, signaling pathway from g-protein families, thrombin signaling and protease-activated receptors
UniProt: P63211
Entrez ID: 2792
|
Does Knockout of UBXN4 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
UBXN4
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: UBXN4 (UBX domain protein 4)
Type: protein-coding
Summary: UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: ERAD pathway, response to unfolded protein; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nuclear envelope, nucleus
Pathways: Protein processing in endoplasmic reticulum - Homo sapiens (human)
UniProt: Q92575
Entrez ID: 23190
|
Does Knockout of RASL11A in Hepatoma Cell Line causally result in response to virus?
| 0
| 2,447
|
Knockout
|
RASL11A
|
response to virus
|
Hepatoma Cell Line
|
Gene: RASL11A (RAS like family 11 member A)
Type: protein-coding
Summary: RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins.[supplied by OMIM, Nov 2008]
Gene Ontology: BP: positive regulation of transcription by RNA polymerase I; MF: G protein activity, GTP binding, GTPase activity, hydrolase activity, nucleotide binding, protein binding; CC: nucleolus, nucleus
Pathways:
UniProt: Q6T310
Entrez ID: 387496
|
Does Knockout of CYB5R3 in Colonic Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,736
|
Knockout
|
CYB5R3
|
response to chemicals
|
Colonic Adenocarcinoma Cell Line
|
Gene: CYB5R3 (cytochrome b5 reductase 3)
Type: protein-coding
Summary: This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010].
Gene Ontology: BP: blood circulation, cholesterol biosynthetic process, cholesterol metabolic process, lipid metabolic process, nitric oxide biosynthetic process, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process; MF: FAD binding, cytochrome-b5 reductase activity, acting on NAD(P)H, nitrite reductase (NO-forming) activity, oxidoreductase activity, protein binding; CC: azurophil granule lumen, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular region, hemoglobin complex, lipid droplet, membrane, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, nitric-oxide synthase complex
Pathways: Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Biological oxidations, Immune System, Innate Immune System, Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Neutrophil degranulation, Oxidation by Cytochrome P450, Phase I - Functionalization of compounds, Vitamin C (ascorbate) metabolism
UniProt: P00387
Entrez ID: 1727
|
Does Activation of CD7 in T cell causally result in protein/peptide accumulation?
| 0
| 2,426
|
Activation
|
CD7
|
protein/peptide accumulation
|
T cell
|
Gene: CD7 (CD7 molecule)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily. This protein is found on thymocytes and mature T cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interaction during early lymphoid development. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: T cell activation, adaptive immune response, cell surface receptor protein tyrosine kinase signaling pathway, immune response, immune system process, interleukin-2-mediated signaling pathway, positive regulation of T cell cytokine production; MF: protein binding, signaling receptor activity, transmembrane signaling receptor activity; CC: membrane, plasma membrane
Pathways: Hematopoietic cell lineage - Homo sapiens (human), TCR
UniProt: P09564
Entrez ID: 924
|
Does Knockout of GAK in Breast Cancer Cell Line causally result in cell proliferation?
| 1
| 235
|
Knockout
|
GAK
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: GAK (cyclin G associated kinase)
Type: protein-coding
Summary: In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: Golgi organization, Golgi to lysosome transport, clathrin coat assembly, clathrin coat disassembly, clathrin-dependent endocytosis, endoplasmic reticulum organization, intracellular transport, negative regulation of neuron projection development, protein folding, protein localization to Golgi apparatus, protein localization to plasma membrane, receptor-mediated endocytosis, regulation of clathrin coat assembly, synaptic vesicle uncoating; MF: ATP binding, clathrin binding, cyclin binding, kinase activity, nucleotide binding, protein binding, protein folding chaperone, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: Golgi apparatus, anchoring junction, clathrin-coated vesicle, cytoplasm, cytoplasmic vesicle, cytosol, focal adhesion, intracellular membrane-bounded organelle, membrane, perinuclear region of cytoplasm, presynapse, vesicle
Pathways: Clathrin-mediated endocytosis, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, Vesicle-mediated transport, trans-Golgi Network Vesicle Budding
UniProt: O14976
Entrez ID: 2580
|
Does Knockout of NXF1 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
NXF1
|
cell proliferation
|
Bladder Carcinoma
|
Gene: NXF1 (nuclear RNA export factor 1)
Type: protein-coding
Summary: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA export from nucleus, mRNA export from nucleus, mRNA transport, poly(A)+ mRNA export from nucleus, protein transport; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, nuclear RNA export factor complex, nuclear envelope, nuclear inclusion body, nuclear pore, nuclear speck, nucleoplasm, nucleus, transcription export complex
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Herpes simplex virus 1 infection - Homo sapiens (human), Influenza A - Homo sapiens (human), Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human), Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA Derived from an Intronless Transcript, Transport of Mature mRNA derived from an Intron-Containing Transcript, Transport of Mature mRNAs Derived from Intronless Transcripts, Transport of the SLBP Dependant Mature mRNA, Transport of the SLBP independent Mature mRNA, mRNA Processing, mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q9UBU9
Entrez ID: 10482
|
Does Knockout of KIF23 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
KIF23
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: KIF23 (kinesin family member 23)
Type: protein-coding
Summary: The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: cell division, microtubule-based movement, mitotic cytokinesis, mitotic spindle elongation, mitotic spindle midzone assembly, positive regulation of cytokinesis; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide binding, protein binding; CC: Flemming body, centralspindlin complex, centrosome, cytoplasm, cytoskeleton, cytosol, focal adhesion, kinesin complex, microtubule, midbody, mitochondrion, mitotic spindle, nucleoplasm, nucleus, spindle
Pathways: Aurora B signaling, MicroRNAs in cancer - Homo sapiens (human)
UniProt: Q02241
Entrez ID: 9493
|
Does Knockout of GRB2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
GRB2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: GRB2 (growth factor receptor bound protein 2)
Type: protein-coding
Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell receptor signaling pathway, Ras protein signal transduction, Schwann cell development, T cell activation, T cell costimulation, actin cytoskeleton organization, anatomical structure formation involved in morphogenesis, branching involved in labyrinthine layer morphogenesis, cellular response to ionizing radiation, endodermal cell differentiation, epidermal growth factor receptor signaling pathway, fibroblast growth factor receptor signaling pathway, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, myelination, natural killer cell mediated cytotoxicity, negative regulation of natural killer cell mediated cytotoxicity, positive regulation of actin filament polymerization, positive regulation of reactive oxygen species metabolic process, receptor internalization, regulation of MAPK cascade, signal transduction, signal transduction in response to DNA damage; MF: RNA binding, SH3 domain binding, ephrin receptor binding, epidermal growth factor receptor binding, guanyl-nucleotide exchange factor adaptor activity, identical protein binding, insulin receptor substrate binding, neurotrophin TRKA receptor binding, phosphotyrosine residue binding, protein binding, protein domain specific binding, protein kinase binding, protein phosphatase binding, protein-macromolecule adaptor activity, transmembrane receptor protein tyrosine kinase adaptor activity; CC: COP9 signalosome, Golgi apparatus, Grb2-EGFR complex, cell cortex, cell-cell junction, centrosome, cytoplasm, cytosol, endosome, extracellular exosome, membrane, nucleoplasm, nucleus, plasma membrane, vesicle membrane
Pathways: 16p11.2 distal deletion syndrome, Activated NTRK2 signals through FRS2 and FRS3, Activated NTRK2 signals through PI3K, Activated NTRK2 signals through RAS, Activated NTRK3 signals through RAS, Acute myeloid leukemia - Homo sapiens (human), Adaptive Immune System, Alcoholism - Homo sapiens (human), Alpha 6 Beta 4 signaling pathway, Alpha6Beta4Integrin, Angiopoietin receptor Tie2-mediated signaling, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, Association Between Physico-Chemical Features and Toxicity Associated Pathways, Axon guidance, B Cell Receptor Signaling Pathway, B cell receptor signaling pathway - Homo sapiens (human), BCR, BCR signaling pathway, BDNF, BDNF-TrkB Signaling, Bacterial Infection Pathways, Brain-derived neurotrophic factor (BDNF) signaling pathway, Breast cancer - Homo sapiens (human), Breast cancer pathway, CD28 dependent Vav1 pathway, Cargo recognition for clathrin-mediated endocytosis, Cell surface interactions at the vascular wall, Cell-Cell communication, Chemokine signaling pathway, Chemokine signaling pathway - Homo sapiens (human), Choline metabolism in cancer - Homo sapiens (human), Chronic myeloid leukemia - Homo sapiens (human), Clathrin-mediated endocytosis, Co-inhibition by BTLA, Co-stimulation by CD28, Colorectal cancer - Homo sapiens (human), Constitutive Signaling by Aberrant PI3K in Cancer, Constitutive Signaling by EGFRvIII, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Constitutive Signaling by Overexpressed ERBB2, Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, DNA damage response (only ATM dependent), Developmental Biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Downstream signal transduction, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, EGF-EGFR signaling pathway, EGFR Transactivation by Gastrin, EGFR Tyrosine Kinase Inhibitor Resistance, EGFR downregulation, EGFR-dependent Endothelin signaling events, EGFR1, EPHA2 forward signaling, EPHB forward signaling, EPO Receptor Signaling, EPO signaling pathway, ESC Pluripotency Pathways, Endometrial cancer, Endometrial cancer - Homo sapiens (human), Envelope proteins and their potential roles in EDMD physiopathology, Epithelial to mesenchymal transition in colorectal cancer, ErbB signaling pathway, ErbB signaling pathway - Homo sapiens (human), ErbB1 downstream signaling, ErbB2/ErbB3 signaling events, ErbB4 signaling events, Erythropoietin activates RAS, Estrogen signaling pathway - Homo sapiens (human), FCERI mediated Ca+2 mobilization, FCERI mediated MAPK activation, FCGR3A-mediated phagocytosis, FGF signaling pathway, FGFR1 mutant receptor activation, FLT3 Signaling, FLT3 signaling in disease, FRS-mediated FGFR1 signaling, FRS-mediated FGFR2 signaling, FRS-mediated FGFR3 signaling, FRS-mediated FGFR4 signaling, Fc Epsilon Receptor I Signaling in Mast Cells, Fc epsilon RI signaling pathway - Homo sapiens (human), Fc epsilon receptor (FCERI) signaling, Fc-epsilon receptor I signaling in mast cells, Fcgamma receptor (FCGR) dependent phagocytosis, Fibroblast growth factor-1, Focal Adhesion, Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Focal adhesion - Homo sapiens (human), FoxO signaling pathway - Homo sapiens (human), Fragile X Syndrome, G alpha (q) signalling events, GAB1 signalosome, GMCSF-mediated signaling events, GPCR downstream signalling, GRB2 events in EGFR signaling, GRB2 events in ERBB2 signaling, GRB2:SOS provides linkage to MAPK signaling for Integrins , Gap junction - Homo sapiens (human), Gastric cancer - Homo sapiens (human), Gastrin, Gastrin signaling pathway, Gastrin-CREB signalling pathway via PKC and MAPK, Ghrelin, Glioblastoma signaling pathways, Glioma - Homo sapiens (human), GnRH signaling pathway - Homo sapiens (human), Growth hormone synthesis, secretion and action - Homo sapiens (human), Hemostasis, Hepatitis B - Homo sapiens (human), Hepatitis B infection, Hepatitis C - Homo sapiens (human), Hepatitis C and Hepatocellular Carcinoma, Hepatocellular carcinoma - Homo sapiens (human), Human cytomegalovirus infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), IGF1 pathway, IGF1R signaling cascade, IL-2 signaling pathway, IL-3 signaling pathway, IL-4 signaling pathway, IL-5 signaling pathway, IL-6 signaling pathway, IL-9 signaling pathway, IL2, IL2 signaling events mediated by PI3K, IL2 signaling events mediated by STAT5, IL2-mediated signaling events, IL3, IL3-mediated signaling events, IL4, IL4-mediated signaling events, IL5, IL5-mediated signaling events, IL6, IL6-mediated signaling events, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Infectious disease, InlB-mediated entry of Listeria monocytogenes into host cell, Innate Immune System, Insulin Pathway, Insulin Signaling, Insulin Signalling, Insulin receptor signalling cascade, Insulin signaling pathway - Homo sapiens (human), Integrin signaling, Integrin-mediated Cell Adhesion, Interleukin receptor SHC signaling, Interleukin-11 Signaling Pathway, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Internalization of ErbB1, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Homo sapiens (human), Kallmann,s Syndrome, Kit receptor signaling pathway, KitReceptor, Leishmania infection, Leishmania phagocytosis, Leptin, Leptin signaling pathway, Listeria monocytogenes entry into host cells, MAPK Cascade, MAPK Signaling Pathway, MAPK family signaling cascades, MAPK signaling pathway - Homo sapiens (human), MAPK1/MAPK3 signaling, MET activates PI3K/AKT signaling, MET activates PTPN11, MET activates RAP1 and RAC1, MET activates RAS signaling, MET promotes cell motility, MET receptor recycling, Melanoma, Membrane Trafficking, MicroRNAs in cancer - Homo sapiens (human), Modulators of TCR signaling and T cell activation, NCAM signaling for neurite out-growth, Natural killer cell mediated cytotoxicity - Homo sapiens (human), Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of MET activity, Negative regulation of the PI3K/AKT network, Nephrin/Neph1 signaling in the kidney podocyte, Nervous system development, Neurotrophic factor-mediated Trk receptor signaling, Neurotrophin signaling pathway - Homo sapiens (human), Non-small cell lung cancer, Non-small cell lung cancer - Homo sapiens (human), Oncostatin M Signaling Pathway, Oncostatin_M, Osteoclast differentiation - Homo sapiens (human), PDGFR-alpha signaling pathway, PDGFR-beta signaling pathway, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K events in ERBB2 signaling, PI3K-Akt signaling pathway, PI3K-Akt signaling pathway - Homo sapiens (human), PI3K/AKT Signaling in Cancer, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Parasite infection, Parasitic Infection Pathways, Pathways in cancer - Homo sapiens (human), Phospholipase D signaling pathway - Homo sapiens (human), Pilocytic astrocytoma, Plasma membrane estrogen receptor signaling, Platelet Aggregation (Plug Formation), Platelet activation, signaling and aggregation, Potential therapeutics for SARS, Prolactin, Prolactin Signaling Pathway, Prolactin signaling pathway - Homo sapiens (human), Prostate cancer - Homo sapiens (human), Proteoglycans in cancer - Homo sapiens (human), RAC1-PAK1-p38-MMP2 Pathway, RAF/MAP kinase cascade, RET signaling, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate WASPs and WAVEs, RHOU GTPase cycle, Ras signaling, Ras signaling pathway - Homo sapiens (human), Regulation of KIT signaling, Regulation of Ras family activation, Regulation of T cell activation by CD28 family, Regulation of actin dynamics for phagocytic cup formation, Regulation of signaling by CBL, Relaxin signaling pathway - Homo sapiens (human), Renal cell carcinoma - Homo sapiens (human), Role of LAT2/NTAL/LAB on calcium mobilization, SARS-CoV Infections, SHC-mediated cascade:FGFR1, SHC-mediated cascade:FGFR2, SHC-mediated cascade:FGFR3, SHC-mediated cascade:FGFR4, SHC-related events triggered by IGF1R, SHC1 events in EGFR signaling, SHC1 events in ERBB2 signaling, SHC1 events in ERBB4 signaling, SHP2 signaling, SOS-mediated signalling, STAT5 Activation, Signal Transduction, Signal attenuation, Signal regulatory protein family interactions, Signaling by CSF1 (M-CSF) in myeloid cells, Signaling by EGFR, Signaling by EGFR in Cancer, Signaling by EGFRvIII in Cancer, Signaling by ERBB2, Signaling by ERBB2 ECD mutants, Signaling by ERBB2 KD Mutants, Signaling by ERBB2 TMD/JMD mutants, Signaling by ERBB2 in Cancer, Signaling by ERBB4, Signaling by Erythropoietin, Signaling by FGFR, Signaling by FGFR in disease, Signaling by FGFR1, Signaling by FGFR1 in disease, Signaling by FGFR2, Signaling by FGFR2 in disease, Signaling by FGFR3, Signaling by FGFR3 in disease, Signaling by FGFR4, Signaling by FGFR4 in disease, Signaling by FLT3 fusion proteins, Signaling by GPCR, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by KIT in disease, Signaling by Ligand-Responsive EGFR Variants in Cancer, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRK2 (TRKB), Signaling by NTRK3 (TRKC), Signaling by NTRKs, Signaling by PDGF, Signaling by PDGFR in disease, Signaling by PDGFRA extracellular domain mutants, Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by cytosolic FGFR1 fusion mutants, Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants, Signaling by the B Cell Receptor (BCR), Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), Signaling events mediated by PTP1B, Signaling events mediated by Stem cell factor receptor (c-Kit), Signaling events mediated by TCPTP, Signaling events mediated by VEGFR1 and VEGFR2, Signaling events mediated by focal adhesion kinase, Signaling events regulated by Ret tyrosine kinase, Signaling of Hepatocyte Growth Factor Receptor, Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human), Signalling to ERKs, Signalling to RAS, Spry regulation of FGF signaling, T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, T-cell receptor (TCR) signaling pathway, TCR, TCR signaling in naïve CD4+ T cells, TCR signaling in naïve CD8+ T cells, TGF-beta Signaling Pathway, TGF-beta receptor signaling, TNF-alpha signaling pathway, TNFalpha, Thermogenesis, Thermogenesis - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, Tie2 Signaling, Trk receptor signaling mediated by PI3K and PLC-gamma, VEGFA-VEGFR2 Signaling Pathway, VEGFR3 signaling in lymphatic endothelium, Vesicle-mediated transport, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), a6b1 and a6b4 Integrin signaling, angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling, bcr signaling pathway, bioactive peptide induced signaling pathway, calcium signaling by hbx of hepatitis b virus, cbl mediated ligand-induced downregulation of egf receptors pathway, egf signaling pathway, epo signaling pathway, erk1/erk2 mapk signaling pathway, fc epsilon receptor i signaling in mast cells, growth hormone signaling pathway, igf-1 signaling pathway, il 2 signaling pathway, il 3 signaling pathway, il 4 signaling pathway, il 6 signaling pathway, il-2 receptor beta chain in t cell activation, inhibition of cellular proliferation by gleevec, insulin signaling pathway, integrin signaling pathway, keratinocyte differentiation, links between pyk2 and map kinases, mTOR signaling pathway - Homo sapiens (human), map kinase inactivation of smrt corepressor, mcalpain and friends in cell motility, multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation, nerve growth factor pathway (ngf), nfat and hypertrophy of the heart , p38 MAPK Signaling Pathway, pdgf signaling pathway, phospholipids as signalling intermediaries, phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway, pten dependent cell cycle arrest and apoptosis, role of egf receptor transactivation by gpcrs in cardiac hypertrophy, role of erbb2 in signal transduction and oncology, role of erk5 in neuronal survival pathway, sprouty regulation of tyrosine kinase signals, t cell receptor signaling pathway, the co-stimulatory signal during t-cell activation, the igf-1 receptor and longevity, tpo signaling pathway, transcription factor creb and its extracellular signals, trefoil factors initiate mucosal healing, trka receptor signaling pathway, vegf hypoxia and angiogenesis
UniProt: P62993
Entrez ID: 2885
|
Does Knockout of ERLIN2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
ERLIN2
|
cell proliferation
|
Cancer Cell Line
|
Gene: ERLIN2 (ER lipid raft associated 2)
Type: protein-coding
Summary: This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: ERAD pathway, SREBP signaling pathway, cholesterol metabolic process, lipid metabolic process, negative regulation of cholesterol biosynthetic process, negative regulation of fatty acid biosynthetic process, regulation of cholesterol biosynthetic process, steroid metabolic process; MF: cholesterol binding, protein binding, ubiquitin protein ligase binding; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, membrane raft, plasma membrane, protein-containing complex
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), Adaptive Immune System, Co-inhibition by PD-1, Defective CFTR causes cystic fibrosis, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, FGFR1 mutant receptor activation, Immune System, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Signaling by FGFR in disease, Signaling by FGFR1 in disease, Signaling by plasma membrane FGFR1 fusions, Transport of small molecules
UniProt: O94905
Entrez ID: 11160
|
Does Knockout of BHLHE22 in Melanoma Cell Line causally result in response to chemicals?
| 1
| 1,940
|
Knockout
|
BHLHE22
|
response to chemicals
|
Melanoma Cell Line
|
Gene: BHLHE22 (basic helix-loop-helix family member e22)
Type: protein-coding
Summary: This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors that regulate cell fate determination, proliferation, and differentiation. A similar protein in mouse is required for the development of the dorsal cochlear nuclei, and is thought to play a role in in the differentiation of neurons involved in sensory input. The mouse protein also functions in retinogenesis. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: axon development, nervous system development, positive regulation of transcription by RNA polymerase II, sensory organ development; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, protein dimerization activity, sequence-specific double-stranded DNA binding; CC: chromatin, nucleus
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Regulation of CDH11 Expression and Function, Regulation of CDH11 gene transcription, Regulation of Expression and Function of Type II Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion
UniProt: Q8NFJ8
Entrez ID: 27319
|
Does Knockout of ZNF787 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,033
|
Knockout
|
ZNF787
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: ZNF787 (zinc finger protein 787)
Type: protein-coding
Summary: Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q6DD87
Entrez ID: 126208
|
Does Knockout of SNRPA in Glioma Cell Line causally result in protein/peptide accumulation?
| 0
| 589
|
Knockout
|
SNRPA
|
protein/peptide accumulation
|
Glioma Cell Line
|
Gene: SNRPA (small nuclear ribonucleoprotein polypeptide A)
Type: protein-coding
Summary: The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: DNA binding, RNA binding, U1 snRNA binding, U1 snRNP binding, identical protein binding, nucleic acid binding, protein binding; CC: U1 snRNP, U4/U6 x U5 tri-snRNP complex, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex, spliceosomal snRNP complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, spliceosomal assembly
UniProt: P09012
Entrez ID: 6626
|
Does Knockout of MRPS18C in Diffuse Large B-cell Lymphoma Cell causally result in response to chemicals?
| 0
| 2,222
|
Knockout
|
MRPS18C
|
response to chemicals
|
Diffuse Large B-cell Lymphoma Cell
|
Gene: MRPS18C (mitochondrial ribosomal protein S18C)
Type: protein-coding
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: mitochondrial translation, translation; MF: small ribosomal subunit rRNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation initiation, Mitochondrial translation termination, Ribosome - Homo sapiens (human), Translation
UniProt: Q9Y3D5
Entrez ID: 51023
|
Does Knockout of RPF1 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
RPF1
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: RPF1 (ribosome production factor 1 homolog)
Type: protein-coding
Summary: Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: maturation of 5.8S rRNA, maturation of LSU-rRNA, rRNA processing, ribosome biogenesis; MF: RNA binding, protein binding, rRNA binding, rRNA primary transcript binding; CC: nucleolus, nucleus, preribosome, large subunit precursor
Pathways:
UniProt: Q9H9Y2
Entrez ID: 80135
|
Does Knockout of UGGT1 in Gastric Cancer Cell Line causally result in cell proliferation?
| 0
| 230
|
Knockout
|
UGGT1
|
cell proliferation
|
Gastric Cancer Cell Line
|
Gene: UGGT1 (UDP-glucose glycoprotein glucosyltransferase 1)
Type: protein-coding
Summary: UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009].
Gene Ontology: BP: 'de novo' post-translational protein folding, UDP-glucosylation, endoplasmic reticulum mannose trimming, protein N-linked glycosylation via asparagine, protein glycosylation; MF: UDP-glucose:glycoprotein glucosyltransferase activity, glycosyltransferase activity, protein binding, transferase activity, unfolded protein binding; CC: endoplasmic reticulum, endoplasmic reticulum lumen, endoplasmic reticulum quality control compartment, endoplasmic reticulum-Golgi intermediate compartment, extracellular exosome, protein-containing complex
Pathways: Asparagine N-linked glycosylation, Calnexin/calreticulin cycle, ER Quality Control Compartment (ERQC), IL-18 signaling pathway, Metabolism of proteins, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, Post-translational protein modification, Protein processing in endoplasmic reticulum - Homo sapiens (human), er associated degradation (erad) pathway
UniProt: Q9NYU2
Entrez ID: 56886
|
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