prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of MAD2L1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | MAD2L1 | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: MAD2L1 (mitotic arrest deficient 2 like 1)
Type: protein-coding
Summary: MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromoso... |
Does Knockout of BPTF in Monocytic Leukemia Cell Line causally result in cell proliferation? | 1 | 206 | Knockout | BPTF | cell proliferation | Monocytic Leukemia Cell Line | Gene: BPTF (bromodomain PHD finger transcription factor)
Type: protein-coding
Summary: This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reac... |
Does Knockout of MMS22L in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 408 | Knockout | MMS22L | cell proliferation | Medulloblastoma Cell Line | Gene: MMS22L (MMS22 like, DNA repair protein)
Type: protein-coding
Summary: The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded pro... |
Does Knockout of IL10 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | IL10 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: IL10 (interleukin 10)
Type: protein-coding
Summary: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, M... |
Does Knockout of BIN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 305 | Knockout | BIN1 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: BIN1 (bridging integrator 1)
Type: protein-coding
Summary: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system ma... |
Does Knockout of EIF2S2 in Cancer Cell Line causally result in cell proliferation? | 1 | 193 | Knockout | EIF2S2 | cell proliferation | Cancer Cell Line | Gene: EIF2S2 (eukaryotic translation initiation factor 2 subunit beta)
Type: protein-coding
Summary: Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2... |
Does Knockout of ATP13A1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | ATP13A1 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: ATP13A1 (ATPase 13A1)
Type: protein-coding
Summary: Enables transmembrane protein dislocase activity. Involved in extraction of mislocalized protein from ER membrane. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: extraction of mislocalized pr... |
Does Knockout of RPS3 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | RPS3 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: RPS3 (ribosomal protein S3)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ... |
Does Knockout of NMD3 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,352 | Knockout | NMD3 | response to chemicals | Cervical Adenocarcinoma Cell Line | Gene: NMD3 (NMD3 ribosome export adaptor)
Type: protein-coding
Summary: Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Sev... |
Does Knockout of GCSH in Multiple Myeloma Cell Line causally result in cell proliferation? | 1 | 816 | Knockout | GCSH | cell proliferation | Multiple Myeloma Cell Line | Gene: GCSH (glycine cleavage system protein H)
Type: protein-coding
Summary: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-con... |
Does Knockout of CDC123 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | CDC123 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: CDC123 (cell division cycle 123)
Type: protein-coding
Summary: Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly and positive regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontol... |
Does Knockout of NDUFAF8 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | NDUFAF8 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: NDUFAF8 (NADH:ubiquinone oxidoreductase complex assembly factor 8)
Type: protein-coding
Summary: Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Implicated in nuclear type mitochondrial complex I deficiency 34. [provided by Alliance of Genome Resources, Ap... |
Does Knockout of TRIM49D1 in Astrocytoma Cell Line causally result in cell proliferation? | 1 | 904 | Knockout | TRIM49D1 | cell proliferation | Astrocytoma Cell Line | Gene: TRIM49D1 (tripartite motif containing 49D1)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance... |
Does Knockout of POMP in Primary Effusion Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,061 | Knockout | POMP | response to chemicals | Primary Effusion Lymphoma Cell Line | Gene: POMP (proteasome maturation protein)
Type: protein-coding
Summary: The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome compl... |
Does Knockout of UBR4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 897 | Knockout | UBR4 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: UBR4 (ubiquitin protein ligase E3 component n-recognin 4)
Type: protein-coding
Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protei... |
Does Knockout of DNAH12 in Cancer Cell Line causally result in cell proliferation? | 0 | 1,308 | Knockout | DNAH12 | cell proliferation | Cancer Cell Line | Gene: DNAH12 (dynein axonemal heavy chain 12)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Pre... |
Does Knockout of LONP2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | LONP2 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: LONP2 (lon peptidase 2, peroxisomal)
Type: protein-coding
Summary: In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role i... |
Does Knockout of COA6 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | COA6 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: COA6 (cytochrome c oxidase assembly factor 6)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome c oxidase subunit 6B family. The encoded protein associates with cytochrome c oxidase may act has an cytochrome c oxidase mitochondrial respiratory complex VI assembly factor. M... |
Does Knockout of PHYKPL in Monocytic Leukemia Cell Line causally result in response to chemicals? | 1 | 1,978 | Knockout | PHYKPL | response to chemicals | Monocytic Leukemia Cell Line | Gene: PHYKPL (5-phosphohydroxy-L-lysine phospho-lyase)
Type: protein-coding
Summary: This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphoh... |
Does Knockout of SELENOK in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,658 | Knockout | SELENOK | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: SELENOK (selenoprotein K)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins... |
Does Knockout of C2CD4A in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | C2CD4A | cell proliferation | Hepatoma Cell Line | Gene: C2CD4A (C2 calcium dependent domain containing 4A)
Type: protein-coding
Summary: Involved in positive regulation of acute inflammatory response; regulation of cell adhesion; and regulation of vascular permeability involved in acute inflammatory response. Located in nucleus. [provided by Alliance o... |
Does Inhibition of GTF2H5 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,184 | Inhibition | GTF2H5 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: GTF2H5 (general transcription factor IIH subunit 5)
Type: protein-coding
Summary: This gene encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and ... |
Does Knockout of TNFRSF21 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 0 | 2,114 | Knockout | TNFRSF21 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: TNFRSF21 (TNF receptor superfamily member 21)
Type: protein-coding
Summary: This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces... |
Does Knockout of GCLC in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals? | 1 | 1,391 | Knockout | GCLC | response to chemicals | Non-Small Cell Lung Adenocarcinoma Cell Line | Gene: GCLC (glutamate-cysteine ligase catalytic subunit)
Type: protein-coding
Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulat... |
Does Knockout of NIPSNAP2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation? | 0 | 2,404 | Knockout | NIPSNAP2 | protein/peptide accumulation | Cervical Adenocarcinoma Cell Line | Gene: NIPSNAP2 (nipsnap homolog 2)
Type: protein-coding
Summary: This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. The encoded protein is localized to mitochondria and plays a role in oxidative phosphorylation. A pseudogene of this gene is located ... |
Does Knockout of WDR75 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | WDR75 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: WDR75 (WD repeat domain 75)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology... |
Does Knockout of DHX33 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | DHX33 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: DHX33 (DEAH-box helicase 33)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving a... |
Does Knockout of PFKFB2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 427 | Knockout | PFKFB2 | cell proliferation | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2)
Type: protein-coding
Summary: The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-ph... |
Does Knockout of CCDC9 in Glioblastoma Cell Line causally result in cell proliferation? | 1 | 906 | Knockout | CCDC9 | cell proliferation | Glioblastoma Cell Line | Gene: CCDC9 (coiled-coil domain containing 9)
Type: protein-coding
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding
Pathways: IL-18 signaling pathway
UniProt: Q9Y3X0
Entrez ID: 2... |
Does Knockout of KRTAP12-4 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | KRTAP12-4 | response to chemicals | Colorectal Cancer Cell Line | Gene: KRTAP12-4 (keratin associated protein 12-4)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: P... |
Does Knockout of GTF2H1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | GTF2H1 | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: GTF2H1 (general transcription factor IIH subunit 1)
Type: protein-coding
Summary: Enables thyroid hormone receptor binding activity. Involved in positive regulation of transcription, DNA-templated and transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor TFIIH co... |
Does Knockout of IGBP1 in acute lymphoblastic leukemia cell line causally result in cell proliferation? | 1 | 1,957 | Knockout | IGBP1 | cell proliferation | acute lymphoblastic leukemia cell line | Gene: IGBP1 (immunoglobulin binding protein 1)
Type: protein-coding
Summary: The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex... |
Does Knockout of SAMM50 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | SAMM50 | cell proliferation | Colonic Cancer Cell Line | Gene: SAMM50 (SAMM50 sorting and assembly machinery component)
Type: protein-coding
Summary: This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membr... |
Does Knockout of PSMA7 in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | PSMA7 | cell proliferation | Bladder Carcinoma | Gene: PSMA7 (proteasome 20S subunit alpha 7)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are comp... |
Does Knockout of BCAT1 in Medulloblastoma Cell Line causally result in cell proliferation? | 0 | 408 | Knockout | BCAT1 | cell proliferation | Medulloblastoma Cell Line | Gene: BCAT1 (branched chain amino acid transaminase 1)
Type: protein-coding
Summary: This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential... |
Does Knockout of SRF in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 1 | 220 | Knockout | SRF | cell proliferation | Mammary Gland Tumor Cell Line | Gene: SRF (serum response factor)
Type: protein-coding
Summary: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the s... |
Does Knockout of ATP6V0C in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | ATP6V0C | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: ATP6V0C (ATPase H+ transporting V0 subunit c)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intrac... |
Does Knockout of ZWINT in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | ZWINT | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: ZWINT (ZW10 interacting kinetochore protein)
Type: protein-coding
Summary: This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kin... |
Does Knockout of SNRNP35 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | SNRNP35 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: SNRNP35 (small nuclear ribonucleoprotein U11/U12 subunit 35)
Type: protein-coding
Summary: The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is... |
Does Knockout of PSMA3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | PSMA3 | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: PSMA3 (proteasome 20S subunit alpha 3)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 ri... |
Does Knockout of LGALS3BP in T-lymphoma cell line causally result in cell proliferation? | 0 | 478 | Knockout | LGALS3BP | cell proliferation | T-lymphoma cell line | Gene: LGALS3BP (galectin 3 binding protein)
Type: protein-coding
Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the hu... |
Does Knockout of MEMO1 in Prostate Cancer Cell Line causally result in response to chemicals? | 1 | 2,109 | Knockout | MEMO1 | response to chemicals | Prostate Cancer Cell Line | Gene: MEMO1 (mediator of cell motility 1)
Type: protein-coding
Summary: Involved in regulation of microtubule-based process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, nucleus
Pathways: ERBB2 Regulates Cell Motility,... |
Does Knockout of MCM4 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | MCM4 | cell proliferation | Ovarian Cancer Cell Line | Gene: MCM4 (minichromosome maintenance complex component 4)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex forme... |
Does Knockout of BTRC in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | BTRC | cell proliferation | Colonic Cancer Cell Line | Gene: BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin p... |
Does Knockout of TTK in Urinary Bladder Cancer Cell Line causally result in cell proliferation? | 1 | 180 | Knockout | TTK | cell proliferation | Urinary Bladder Cancer Cell Line | Gene: TTK (TTK protein kinase)
Type: protein-coding
Summary: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and i... |
Does Knockout of RINT1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | RINT1 | cell proliferation | Ovarian Cancer Cell Line | Gene: RINT1 (RAD50 interactor 1)
Type: protein-coding
Summary: This gene encodes a protein first identified for its ability to interact with the RAD50 double strand break repair protein, with the resulting interaction implicated in the regulation of cell cycle progression and telomere length. The encode... |
Does Activation of LONRF3 in Hepatoma Cell Line causally result in response to virus? | 1 | 1,210 | Activation | LONRF3 | response to virus | Hepatoma Cell Line | Gene: LONRF3 (LON peptidase N-terminal domain and ring finger 3)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple... |
Does Knockout of PLEKHM1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | PLEKHM1 | cell proliferation | Endometrial Cancer Cell Line | Gene: PLEKHM1 (pleckstrin homology and RUN domain containing M1)
Type: protein-coding
Summary: The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopet... |
Does Knockout of NKTR in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 0 | 734 | Knockout | NKTR | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: NKTR (natural killer cell triggering receptor)
Type: protein-coding
Summary: This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. I... |
Does Knockout of ZSCAN20 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | ZSCAN20 | cell proliferation | Cancer Cell Line | Gene: ZSCAN20 (zinc finger and SCAN domain containing 20)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of ... |
Does Knockout of SOX3 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | SOX3 | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: SOX3 (SRY-box transcription factor 3)
Type: protein-coding
Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcript... |
Does Knockout of CFLAR in Large Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 734 | Knockout | CFLAR | cell proliferation | Large Cell Lung Cancer Cell Line | Gene: CFLAR (CASP8 and FADD like apoptosis regulator)
Type: protein-coding
Summary: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. ... |
Does Knockout of SLC25A34 in Hepatoma Cell Line causally result in cell proliferation? | 0 | 1,206 | Knockout | SLC25A34 | cell proliferation | Hepatoma Cell Line | Gene: SLC25A34 (solute carrier family 25 member 34)
Type: protein-coding
Summary: SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008].
Gene Ontology: CC: membrane, mitochondrial inner membrane, mitochondrio... |
Does Knockout of CAPSL in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | CAPSL | cell proliferation | Astrocytoma Cell Line | Gene: CAPSL (calcyphosine like)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: calcium ion binding, metal ion binding; CC: cytoplasm, organelle
... |
Does Knockout of UBA52 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | UBA52 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1)
Type: protein-coding
Summary: Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chro... |
Does Knockout of DDX6 in Cancer Cell Line causally result in cell proliferation? | 1 | 948 | Knockout | DDX6 | cell proliferation | Cancer Cell Line | Gene: DDX6 (DEAD-box helicase 6)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencin... |
Does Knockout of STX18 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 1 | 763 | Knockout | STX18 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: STX18 (syntaxin 18)
Type: protein-coding
Summary: This gene encodes a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) which is part of a membrane tethering complex that includes other SNAREs and several peripheral membrane proteins, ... |
Does Knockout of ATG10 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 865 | Knockout | ATG10 | cell proliferation | Colonic Cancer Cell Line | Gene: ATG10 (autophagy related 10)
Type: protein-coding
Summary: Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conju... |
Does Knockout of CDKN2A-AS1 in Colorectal Cancer Cell Line causally result in response to chemicals? | 0 | 1,414 | Knockout | CDKN2A-AS1 | response to chemicals | Colorectal Cancer Cell Line | Gene: CDKN2A-AS1 (CDKN2A antisense RNA 1)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: |
Does Knockout of SLC6A14 in Ewing's Sarcoma Cell Line causally result in cell proliferation? | 0 | 763 | Knockout | SLC6A14 | cell proliferation | Ewing's Sarcoma Cell Line | Gene: SLC6A14 (solute carrier family 6 member 14)
Type: protein-coding
Summary: This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This pr... |
Does Knockout of FAM30A in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,340 | Knockout | FAM30A | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: FAM30A (family with sequence similarity 30 member A)
Type: ncRNA
Summary: family with sequence similarity 30 member A
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 9834 |
Does Knockout of PWP1 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | PWP1 | cell proliferation | Ovarian Cancer Cell Line | Gene: PWP1 (PWP1 homolog, endonuclein)
Type: protein-coding
Summary: The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocar... |
Does Knockout of DSG1 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 287 | Knockout | DSG1 | cell proliferation | Endometrial Cancer Cell Line | Gene: DSG1 (desmoglein 1)
Type: protein-coding
Summary: This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shea... |
Does Knockout of FUZ in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | FUZ | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: FUZ (fuzzy planar cell polarity protein)
Type: protein-coding
Summary: This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associate... |
Does Knockout of KDM2A in Bladder Carcinoma causally result in cell proliferation? | 1 | 489 | Knockout | KDM2A | cell proliferation | Bladder Carcinoma | Gene: KDM2A (lysine demethylase 2A)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1... |
Does Knockout of ACP6 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | ACP6 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: ACP6 (acid phosphatase 6, lysophosphatidic)
Type: protein-coding
Summary: This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in bala... |
Does Knockout of TTLL4 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals? | 0 | 2,383 | Knockout | TTLL4 | response to chemicals | Chronic Myelogenous Leukemia Cell Line | Gene: TTLL4 (tubulin tyrosine ligase like 4)
Type: protein-coding
Summary: Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within regul... |
Does Knockout of NUF2 in Medulloblastoma Cell Line causally result in cell proliferation? | 1 | 1,813 | Knockout | NUF2 | cell proliferation | Medulloblastoma Cell Line | Gene: NUF2 (NUF2 component of NDC80 kinetochore complex)
Type: protein-coding
Summary: This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centr... |
Does Knockout of PHF24 in Huh-7 Cell causally result in response to virus? | 0 | 1,382 | Knockout | PHF24 | response to virus | Huh-7 Cell | Gene: PHF24 (PHD finger protein 24)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to act upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of pain; gamma-aminobutyric acid signaling pathway; and re... |
Does Knockout of FGFR1OP2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 839 | Knockout | FGFR1OP2 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: FGFR1OP2 (FGFR1 oncogene partner 2)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in response to wounding. Predicted to act upstream of or within wound healing. Predicted to be located in cytoplasm. [provided by Alliance of Genome Re... |
Does Knockout of UBE2Z in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 287 | Knockout | UBE2Z | cell proliferation | Endometrial Cancer Cell Line | Gene: UBE2Z (ubiquitin conjugating enzyme E2 Z)
Type: protein-coding
Summary: This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic pr... |
Does Knockout of HEPN1 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 951 | Knockout | HEPN1 | cell proliferation | Colonic Cancer Cell Line | Gene: HEPN1 (hepatocellular carcinoma, down-regulated 1)
Type: protein-coding
Summary: This gene is expressed predominantly in the liver. Transient transfection studies show the expression of this gene significantly inhibits cell growth, suggesting a role for this gene in apoptosis. Expression of this g... |
Does Knockout of DAOA in Astrocytoma Cell Line causally result in cell proliferation? | 0 | 904 | Knockout | DAOA | cell proliferation | Astrocytoma Cell Line | Gene: DAOA (D-amino acid oxidase activator)
Type: protein-coding
Summary: This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest t... |
Does Knockout of THOC5 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 815 | Knockout | THOC5 | cell proliferation | Colonic Cancer Cell Line | Gene: THOC5 (THO complex subunit 5)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity. Involved in several processes, including monocyte differentiation; negative regulation of DNA damage checkpoint; and viral mRNA export from host cell nucleus. Located in nucleoplasm. Part of THO ... |
Does Knockout of GJA9 in Multiple Myeloma Cell Line causally result in cell proliferation? | 0 | 816 | Knockout | GJA9 | cell proliferation | Multiple Myeloma Cell Line | Gene: GJA9 (gap junction protein alpha 9)
Type: protein-coding
Summary: Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of whic... |
Does Knockout of ZFP37 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,339 | Knockout | ZFP37 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: ZFP37 (ZFP37 zinc finger protein)
Type: protein-coding
Summary: This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate s... |
Does Knockout of CYB5R4 in Endometrial Cancer Cell Line causally result in cell proliferation? | 1 | 758 | Knockout | CYB5R4 | cell proliferation | Endometrial Cancer Cell Line | Gene: CYB5R4 (cytochrome b5 reductase 4)
Type: protein-coding
Summary: NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010].
Gene On... |
Does Knockout of WDR24 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 305 | Knockout | WDR24 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: WDR24 (WD repeat domain 24)
Type: protein-coding
Summary: Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and regulation of autophagy. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 202... |
Does Knockout of ABRAXAS2 in Endometrial Cancer Cell Line causally result in cell proliferation? | 0 | 758 | Knockout | ABRAXAS2 | cell proliferation | Endometrial Cancer Cell Line | Gene: ABRAXAS2 (abraxas 2, BRISC complex subunit)
Type: protein-coding
Summary: Enables microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Involved in several processes, including mitotic spindle assembly; protein K63-linked deubiquitination; and response to ... |
Does Knockout of NANOS1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals? | 1 | 1,397 | Knockout | NANOS1 | response to chemicals | Chronic Myeloid Leukemia Cell Line | Gene: NANOS1 (nanos C2HC-type zinc finger 1)
Type: protein-coding
Summary: This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a... |
Does Activation of TRIR in T cell causally result in protein/peptide accumulation? | 0 | 2,425 | Activation | TRIR | protein/peptide accumulation | T cell | Gene: TRIR (telomerase RNA component interacting RNase)
Type: protein-coding
Summary: Enables 3'-5' exonuclease activity and 5'-3' exonuclease activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic and rRNA catabolic process. [provided by Alliance of Genome Resources, Apr 2022]
... |
Does Knockout of CPSF6 in Melanoma Cell Line causally result in cell proliferation? | 1 | 527 | Knockout | CPSF6 | cell proliferation | Melanoma Cell Line | Gene: CPSF6 (cleavage and polyadenylation specific factor 6)
Type: protein-coding
Summary: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the ass... |
Does Knockout of ANAPC10 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 1,311 | Knockout | ANAPC10 | cell proliferation | Oral Squamous Cell Carcinoma Cell Line | Gene: ANAPC10 (anaphase promoting complex subunit 10)
Type: protein-coding
Summary: ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitin... |
Does Knockout of STK35 in Breast Cancer Cell Line causally result in cell proliferation? | 0 | 235 | Knockout | STK35 | cell proliferation | Breast Cancer Cell Line | Gene: STK35 (serine/threonine kinase 35)
Type: protein-coding
Summary: The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of acti... |
Does Knockout of DHX15 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 1 | 839 | Knockout | DHX15 | cell proliferation | Lung Squamous Cell Carcinoma Cell Line | Gene: DHX15 (DEAH-box helicase 15)
Type: protein-coding
Summary: The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, antiviral innate immune response, defense response to bact... |
Does Knockout of ADAMTS2 in Cancer Cell Line causally result in cell proliferation? | 0 | 948 | Knockout | ADAMTS2 | cell proliferation | Cancer Cell Line | Gene: ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2)
Type: protein-coding
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a prope... |
Does Knockout of RHOQ in Colorectal Cancer Cell Line causally result in cell proliferation? | 1 | 783 | Knockout | RHOQ | cell proliferation | Colorectal Cancer Cell Line | Gene: RHOQ (ras homolog family member Q)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization... |
Does Knockout of FBXW11 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation? | 1 | 2,114 | Knockout | FBXW11 | cell proliferation | Primary Effusion Lymphoma Cell Line | Gene: FBXW11 (F-box and WD repeat domain containing 11)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase compl... |
Does Knockout of ABT1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation? | 1 | 1,246 | Knockout | ABT1 | cell proliferation | Non-Small Cell Lung Cancer Cell Line | Gene: ABT1 (activator of basal transcription 1)
Type: protein-coding
Summary: Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activa... |
Does Knockout of ZNF112 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals? | 0 | 1,329 | Knockout | ZNF112 | response to chemicals | Retinal Pigment Epithelium Cell Line | Gene: ZNF112 (zinc finger protein 112)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by... |
Does Knockout of FAM161B in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation? | 0 | 1,218 | Knockout | FAM161B | protein/peptide accumulation | Lymphoma or Leukaemia Cell Line | Gene: FAM161B (FAM161 centrosomal protein B)
Type: protein-coding
Summary: Predicted to be involved in cilium organization. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasmic microtubule, cytoskeleton, microtubule cytoskeleton... |
Does Knockout of ZNF71 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,459 | Knockout | ZNF71 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: ZNF71 (zinc finger protein 71)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by R... |
Does Knockout of PGM1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 0 | 1,789 | Knockout | PGM1 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: PGM1 (phosphoglucomutase 1)
Type: protein-coding
Summary: The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between t... |
Does Knockout of GTPBP4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation? | 1 | 149 | Knockout | GTPBP4 | cell proliferation | Chronic Myeloid Leukemia Cell Line | Gene: GTPBP4 (GTP binding protein 4)
Type: protein-coding
Summary: GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal t... |
Does Knockout of PMM2 in Cervical Adenocarcinoma Cell Line causally result in response to virus? | 0 | 2,430 | Knockout | PMM2 | response to virus | Cervical Adenocarcinoma Cell Line | Gene: PMM2 (phosphomannomutase 2)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been sho... |
Does Knockout of C19orf53 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 865 | Knockout | C19orf53 | cell proliferation | Colonic Cancer Cell Line | Gene: C19orf53 (chromosome 19 open reading frame 53)
Type: protein-coding
Summary: chromosome 19 open reading frame 53
Gene Ontology:
Pathways:
UniProt: Q9UNZ5
Entrez ID: 28974 |
Does Knockout of FAT2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation? | 0 | 1,576 | Knockout | FAT2 | cell proliferation | Pre-B Acute Lymphoblastic Leukemia Cell Line | Gene: FAT2 (FAT atypical cadherin 2)
Type: protein-coding
Summary: This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superf... |
Does Knockout of LSM3 in Ovarian Cancer Cell Line causally result in cell proliferation? | 1 | 699 | Knockout | LSM3 | cell proliferation | Ovarian Cancer Cell Line | Gene: LSM3 (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which c... |
Does Knockout of HCN3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation? | 0 | 334 | Knockout | HCN3 | cell proliferation | Esophageal Squamous Cell Carcinoma Cell Line | Gene: HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3)
Type: protein-coding
Summary: This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophospha... |
Does Knockout of SNRPG in Lung Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 387 | Knockout | SNRPG | cell proliferation | Lung Adenocarcinoma Cell Line | Gene: SNRPG (small nuclear ribonucleoprotein polypeptide G)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear rib... |
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