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string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of MAD2L1 in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
MAD2L1
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: MAD2L1 (mitotic arrest deficient 2 like 1)
Type: protein-coding
Summary: MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, establishment of centrosome localization, establishment of mitotic spindle orientation, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, negative regulation of mitotic cell cycle, negative regulation of mitotic cell cycle phase transition, negative regulation of protein catabolic process, negative regulation of ubiquitin protein ligase activity, positive regulation of mitotic cell cycle spindle assembly checkpoint, regulation of nuclear division; MF: identical protein binding, protein binding, protein homodimerization activity; CC: chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, kinetochore, mitotic checkpoint complex, mitotic spindle, mitotic spindle assembly checkpoint MAD1-MAD2 complex, nuclear pore nuclear basket, nucleoplasm, nucleus, perinuclear region of cytoplasm, spindle pole
Pathways: Cell cycle - Homo sapiens (human), Human T-cell leukemia virus 1 infection - Homo sapiens (human), KitReceptor, Oocyte meiosis - Homo sapiens (human), Progesterone-mediated oocyte maturation - Homo sapiens (human), Regulation of sister chromatid separation at the metaphase-anaphase transition
UniProt: Q13257
Entrez ID: 4085
|
Does Knockout of BPTF in Monocytic Leukemia Cell Line causally result in cell proliferation?
| 1
| 206
|
Knockout
|
BPTF
|
cell proliferation
|
Monocytic Leukemia Cell Line
|
Gene: BPTF (bromodomain PHD finger transcription factor)
Type: protein-coding
Summary: This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: anterior/posterior pattern specification, brain development, cellular response to nerve growth factor stimulus, chromatin organization, chromatin remodeling, embryonic placenta development, endoderm development, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: ATP-dependent activity, acting on DNA, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: ATPase complex, NURF complex, cell body, chromatin, cytoplasm, dendrite, extracellular exosome, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: 16p11.2 proximal deletion syndrome, Endoderm differentiation
UniProt: Q12830
Entrez ID: 2186
|
Does Knockout of MMS22L in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 408
|
Knockout
|
MMS22L
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: MMS22L (MMS22 like, DNA repair protein)
Type: protein-coding
Summary: The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded protein also can bind with the histone-associated protein NFKBIL2 to help regulate the chromatin state at stalled replication forks. Finally, this gene appears to be overexpressed in most lung and esophageal cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017].
Gene Ontology: BP: DNA damage response, DNA repair, chromatin organization, double-strand break repair via homologous recombination, protein localization to chromatin, replication fork processing; MF: DNA binding, protein binding, single-stranded DNA binding; CC: FACT complex, MCM complex, chromosome, cytosol, nuclear replication fork, nucleoplasm, nucleus, site of DNA damage, site of double-strand break
Pathways:
UniProt: Q6ZRQ5
Entrez ID: 253714
|
Does Knockout of IL10 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
IL10
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: IL10 (interleukin 10)
Type: protein-coding
Summary: The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020].
Gene Ontology: BP: B cell differentiation, B cell proliferation, branching involved in labyrinthine layer morphogenesis, cellular response to estradiol stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to lipopolysaccharide, chronic inflammatory response to antigenic stimulus, defense response to bacterium, defense response to protozoan, endothelial cell apoptotic process, hemopoiesis, immune response, interleukin-10-mediated signaling pathway, leukocyte chemotaxis, liver regeneration, negative regulation of B cell proliferation, negative regulation of MHC class II biosynthetic process, negative regulation of T cell proliferation, negative regulation of apoptotic process, negative regulation of autophagy, negative regulation of cell population proliferation, negative regulation of chemokine (C-C motif) ligand 5 production, negative regulation of chronic inflammatory response to antigenic stimulus, negative regulation of cytokine activity, negative regulation of cytokine production, negative regulation of cytokine production involved in immune response, negative regulation of endothelial cell apoptotic process, negative regulation of heterotypic cell-cell adhesion, negative regulation of inflammatory response, negative regulation of interferon-alpha production, negative regulation of interleukin-1 production, negative regulation of interleukin-12 production, negative regulation of interleukin-18 production, negative regulation of interleukin-6 production, negative regulation of interleukin-8 production, negative regulation of membrane protein ectodomain proteolysis, negative regulation of mitotic cell cycle, negative regulation of myeloid dendritic cell activation, negative regulation of neuron apoptotic process, negative regulation of nitric oxide biosynthetic process, negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway, negative regulation of tumor necrosis factor production, negative regulation of type II interferon production, negative regulation of vascular associated smooth muscle cell proliferation, positive regulation of B cell apoptotic process, positive regulation of DNA-templated transcription, positive regulation of MHC class II biosynthetic process, positive regulation of cell cycle, positive regulation of cytokine production, positive regulation of endothelial cell proliferation, positive regulation of heterotypic cell-cell adhesion, positive regulation of immunoglobulin production, positive regulation of macrophage activation, positive regulation of miRNA transcription, positive regulation of plasma cell differentiation, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of sprouting angiogenesis, positive regulation of transcription by RNA polymerase II, positive regulation of vascular associated smooth muscle cell proliferation, regulation of complement-dependent cytotoxicity, regulation of gene expression, regulation of isotype switching, regulation of response to wounding, regulation of synapse organization, response to activity, response to carbon monoxide, response to glucocorticoid, response to inactivity, response to insulin, response to lipopolysaccharide, response to molecule of bacterial origin, response to xenobiotic stimulus, type 2 immune response; MF: cytokine activity, growth factor activity, interleukin-10 receptor binding, protein binding, protein dimerization activity; CC: extracellular region, extracellular space
Pathways: AP-1 transcription factor network, Acute viral myocarditis, African trypanosomiasis - Homo sapiens (human), Allograft Rejection, Allograft rejection - Homo sapiens (human), Amoebiasis - Homo sapiens (human), Anti-inflammatory response favouring Leishmania parasite infection, Asthma - Homo sapiens (human), Autoimmune thyroid disease - Homo sapiens (human), C-type lectin receptor signaling pathway - Homo sapiens (human), CD163 mediating an anti-inflammatory response, COVID-19 adverse outcome pathway, Chagas disease - Homo sapiens (human), Control of immune tolerance by vasoactive intestinal peptide, Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Homo sapiens (human), Cytokines and Inflammatory Response, Disease, Diseases of signal transduction by growth factor receptors and second messengers, FCGR3A-mediated IL10 synthesis, FoxO signaling pathway - Homo sapiens (human), Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation, IL-10 Anti-inflammatory Signaling Pathway, IL-18 signaling pathway, IL4-mediated signaling events, Immune System, Infectious disease, Inflammatory bowel disease - Homo sapiens (human), Interleukin-10 signaling, Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-4 and Interleukin-13 signaling, Intestinal immune network for IgA production - Homo sapiens (human), JAK-STAT signaling pathway - Homo sapiens (human), Leishmania infection, Leishmania parasite growth and survival, Leishmaniasis - Homo sapiens (human), Malaria - Homo sapiens (human), Netrin-UNC5B signaling pathway, PI3K-AKT-mTOR - VitD3 signaling, Parasitic Infection Pathways, Pertussis - Homo sapiens (human), Regulation of nuclear SMAD2/3 signaling, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by Interleukins, Staphylococcus aureus infection - Homo sapiens (human), Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, Systemic lupus erythematosus - Homo sapiens (human), T cell receptor signaling pathway - Homo sapiens (human), T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection, Toxoplasmosis - Homo sapiens (human), Tuberculosis - Homo sapiens (human), Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human), Yersinia infection - Homo sapiens (human), il-10 anti-inflammatory signaling pathway, miRNAs involvement in the immune response in sepsis
UniProt: P22301
Entrez ID: 3586
|
Does Knockout of BIN1 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 305
|
Knockout
|
BIN1
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: BIN1 (bridging integrator 1)
Type: protein-coding
Summary: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016].
Gene Ontology: BP: T-tubule organization, cell differentiation, cytoskeleton organization, endocytosis, endosome to lysosome transport, establishment of localization in cell, lipid tube assembly, negative regulation of amyloid-beta formation, negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel, negative regulation of potassium ion transmembrane transport, negative regulation of transcription by RNA polymerase II, negative regulation of ventricular cardiac muscle cell action potential, nucleus organization, positive regulation of actin filament polymerization, positive regulation of apoptotic process, positive regulation of astrocyte differentiation, positive regulation of endocytosis, regulation of cell cycle process, regulation of endocytosis, regulation of heart rate by cardiac conduction, regulation of neuron differentiation, synaptic vesicle endocytosis; MF: GTPase binding, RNA polymerase binding, actin filament binding, aspartic-type endopeptidase inhibitor activity, clathrin binding, identical protein binding, lipid binding, phospholipid binding, protease binding, protein binding, protein-containing complex binding, protein-folding chaperone binding, tau protein binding; CC: I band, RNA polymerase II transcription repressor complex, T-tubule, Z disc, actin cytoskeleton, axon, axon initial segment, axon terminus, cerebellar mossy fiber, cytoplasm, cytoskeleton, cytosol, dendrite, endosome, extrinsic component of synaptic vesicle membrane, glutamatergic synapse, lipid tube, membrane, node of Ranvier, nucleus, plasma membrane, synaptic vesicle, varicosity, vesicle
Pathways: Arf6 trafficking events, Endocytosis - Homo sapiens (human), Fc gamma R-mediated phagocytosis - Homo sapiens (human), IL-18 signaling pathway, VEGFA-VEGFR2 Signaling Pathway, endocytotic role of ndk phosphins and dynamin, p73 transcription factor network
UniProt: O00499
Entrez ID: 274
|
Does Knockout of EIF2S2 in Cancer Cell Line causally result in cell proliferation?
| 1
| 193
|
Knockout
|
EIF2S2
|
cell proliferation
|
Cancer Cell Line
|
Gene: EIF2S2 (eukaryotic translation initiation factor 2 subunit beta)
Type: protein-coding
Summary: Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Gene Ontology: BP: cytoplasmic translational initiation, formation of translation preinitiation complex, in utero embryonic development, male germ cell proliferation, male gonad development, translation, translational initiation; MF: RNA binding, mRNA binding, metal ion binding, protein binding, translation factor activity, RNA binding, translation initiation factor activity, translation initiation factor binding, zinc ion binding; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2 complex, nucleus, synapse
Pathways: ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Antiviral mechanism by IFN-stimulated genes, Brain-derived neurotrophic factor (BDNF) signaling pathway, Cap-dependent Translation Initiation, Cellular response to mitochondrial stress, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Cytokine Signaling in Immune system, Eukaryotic Translation Initiation, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Immune System, Interferon Signaling, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, PERK regulates gene expression, PKR-mediated signaling, RNA transport - Homo sapiens (human), Recycling of eIF2:GDP, Response of EIF2AK1 (HRI) to heme deficiency, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Translation, Translation Factors, Translation initiation complex formation, Transport of small molecules, Unfolded Protein Response (UPR), double stranded rna induced gene expression, eukaryotic protein translation, nsp1 from SARS-CoV-2 inhibits translation initiation in the host cell, regulation of eif2, skeletal muscle hypertrophy is regulated via akt-mtor pathway
UniProt: P20042
Entrez ID: 8894
|
Does Knockout of ATP13A1 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
ATP13A1
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: ATP13A1 (ATPase 13A1)
Type: protein-coding
Summary: Enables transmembrane protein dislocase activity. Involved in extraction of mislocalized protein from ER membrane. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: extraction of mislocalized protein from ER membrane, intracellular calcium ion homeostasis, manganese ion transmembrane transport, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, protein transport, transmembrane transport; MF: ABC-type manganese transporter activity, ATP binding, ATP hydrolysis activity, ATPase-coupled monoatomic cation transmembrane transporter activity, P-type ion transporter activity, P-type transmembrane transporter activity, membrane protein dislocase activity, metal ion binding, nucleotide binding, protein binding; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q9HD20
Entrez ID: 57130
|
Does Knockout of RPS3 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
RPS3
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: RPS3 (ribosomal protein S3)
Type: protein-coding
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012].
Gene Ontology: BP: DNA damage response, DNA repair, apoptotic process, base-excision repair, cell division, cellular response to hydrogen peroxide, cellular response to reactive oxygen species, cellular response to tumor necrosis factor, chromosome segregation, cytoplasmic translation, negative regulation of DNA repair, negative regulation of protein ubiquitination, negative regulation of translation, positive regulation of DNA repair, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell receptor signaling pathway, positive regulation of activated T cell proliferation, positive regulation of apoptotic signaling pathway, positive regulation of base-excision repair, positive regulation of endodeoxyribonuclease activity, positive regulation of gene expression, positive regulation of interleukin-2 production, positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage, positive regulation of microtubule polymerization, positive regulation of non-canonical NF-kappaB signal transduction, positive regulation of protein-containing complex assembly, regulation of apoptotic process, regulation of translation, response to TNF agonist, spindle assembly, translation, translational initiation; MF: DNA N-glycosylase activity, DNA binding, DNA endonuclease activity, DNA-(apurinic or apyrimidinic site) endonuclease activity, DNA-binding transcription factor binding, Hsp70 protein binding, Hsp90 protein binding, RNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, class I DNA-(apurinic or apyrimidinic site) endonuclease activity, damaged DNA binding, enzyme binding, iron-sulfur cluster binding, kinase binding, lyase activity, mRNA binding, microtubule binding, oxidized purine DNA binding, oxidized pyrimidine DNA binding, protein binding, protein kinase A binding, protein kinase binding, protein-containing complex binding, small ribosomal subunit rRNA binding, structural constituent of ribosome, supercoiled DNA binding, tubulin binding, ubiquitin-like protein conjugating enzyme binding; CC: NF-kappaB complex, cytoplasm, cytoskeleton, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, endoplasmic reticulum, extracellular exosome, focal adhesion, membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrion, mitotic spindle, nucleolus, nucleoplasm, nucleus, plasma membrane, postsynaptic density, ribonucleoprotein complex, ribosome, ruffle membrane, small ribosomal subunit, spindle, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Axon guidance, Cap-dependent Translation Initiation, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Coronavirus disease - COVID-19 - Homo sapiens (human), Cytoplasmic Ribosomal Proteins, Developmental Biology, Disease, Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of proteins, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Pathogenic Escherichia coli infection - Homo sapiens (human), Peptide chain elongation, Regulation of expression of SLITs and ROBOs, Response of EIF2AK4 (GCN2) to amino acid deficiency, Ribosomal scanning and start codon recognition, Ribosome - Homo sapiens (human), Ribosome-associated quality control, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 modulates host translation machinery, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SRP-dependent cotranslational protein targeting to membrane, Salmonella infection - Homo sapiens (human), Selenoamino acid metabolism, Selenocysteine synthesis, Signaling by ROBO receptors, Translation, Translation initiation complex formation, Viral Infection Pathways, Viral mRNA Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P23396
Entrez ID: 6188
|
Does Knockout of NMD3 in Cervical Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,352
|
Knockout
|
NMD3
|
response to chemicals
|
Cervical Adenocarcinoma Cell Line
|
Gene: NMD3 (NMD3 ribosome export adaptor)
Type: protein-coding
Summary: Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: positive regulation of RNA biosynthetic process, positive regulation of protein localization to nucleolus, protein transport, ribosomal large subunit export from nucleus; MF: RNA binding, protein-macromolecule adaptor activity, ribosomal large subunit binding; CC: cytoplasm, membrane, nucleolus, nucleoplasm, nucleus
Pathways: RNA transport - Homo sapiens (human), Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q96D46
Entrez ID: 51068
|
Does Knockout of GCSH in Multiple Myeloma Cell Line causally result in cell proliferation?
| 1
| 816
|
Knockout
|
GCSH
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: GCSH (glycine cleavage system protein H)
Type: protein-coding
Summary: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.[provided by RefSeq, Jan 2010].
Gene Ontology: BP: glycine catabolic process, glycine decarboxylation via glycine cleavage system; MF: aminomethyltransferase activity, protein binding; CC: glycine cleavage complex, mitochondrial matrix, mitochondrion
Pathways: Ammonia Recycling, Glycine degradation, Glycine, serine and threonine metabolism - Homo sapiens (human), Glyoxylate and dicarboxylate metabolism - Homo sapiens (human), Glyoxylate metabolism and glycine degradation, Metabolism, Metabolism of amino acids and derivatives, Metabolism of proteins, Post-translational protein modification, Protein lipoylation
UniProt: P23434
Entrez ID: 2653
|
Does Knockout of CDC123 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
CDC123
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: CDC123 (cell division cycle 123)
Type: protein-coding
Summary: Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly and positive regulation of translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: eukaryotic translation initiation factor 2 complex assembly, protein folding; MF: ATP binding, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein folding chaperone; CC: cytoplasm
Pathways:
UniProt: O75794
Entrez ID: 8872
|
Does Knockout of NDUFAF8 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
NDUFAF8
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: NDUFAF8 (NADH:ubiquinone oxidoreductase complex assembly factor 8)
Type: protein-coding
Summary: Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Implicated in nuclear type mitochondrial complex I deficiency 34. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: mitochondrial respiratory chain complex I assembly; CC: mitochondrial matrix, mitochondrion
Pathways: Aerobic respiration and respiratory electron transport, Complex I biogenesis, Metabolism, Respiratory electron transport, Thermogenesis - Homo sapiens (human)
UniProt: A1L188
Entrez ID: 284184
|
Does Knockout of TRIM49D1 in Astrocytoma Cell Line causally result in cell proliferation?
| 1
| 904
|
Knockout
|
TRIM49D1
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: TRIM49D1 (tripartite motif containing 49D1)
Type: protein-coding
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: innate immune response, regulation of gene expression; MF: metal ion binding, ubiquitin protein ligase activity, zinc ion binding
Pathways:
UniProt: C9J1S8
Entrez ID: 399939
|
Does Knockout of POMP in Primary Effusion Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,061
|
Knockout
|
POMP
|
response to chemicals
|
Primary Effusion Lymphoma Cell Line
|
Gene: POMP (proteasome maturation protein)
Type: protein-coding
Summary: The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.[provided by RefSeq, Aug 2010].
Gene Ontology: BP: proteasome assembly; CC: cytoplasm, cytosol, endoplasmic reticulum, membrane, nuclear speck, nucleus
Pathways: Metabolism of proteins, Post-translational protein modification, Proteasome - Homo sapiens (human), Proteasome assembly
UniProt: Q9Y244
Entrez ID: 51371
|
Does Knockout of UBR4 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 897
|
Knockout
|
UBR4
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: UBR4 (ubiquitin protein ligase E3 component n-recognin 4)
Type: protein-coding
Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: HRI-mediated signaling, cellular response to stress, cytoplasm protein quality control, cytoplasm protein quality control by the ubiquitin-proteasome system, cytoplasmic translation, endosome organization, fatty acid biosynthetic process, negative regulation of HRI-mediated signaling, negative regulation of fatty acid biosynthetic process, positive regulation of autophagy, proteasomal protein catabolic process, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein catabolic process, protein quality control for misfolded or incompletely synthesized proteins, protein stabilization, protein targeting to vacuole involved in autophagy, protein ubiquitination, response to oxidative stress, translational initiation, type I interferon-mediated signaling pathway, ubiquitin-dependent protein catabolic process, ubiquitin-dependent protein catabolic process via the N-end rule pathway; MF: calmodulin binding, metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, ubiquitin-like ligase-substrate adaptor activity, ubiquitin-protein transferase activity, zinc ion binding; CC: cytoplasm, cytoskeleton, cytosol, endosome, ficolin-1-rich granule membrane, membrane, nucleus, plasma membrane, specific granule membrane, tertiary granule membrane
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Neutrophil degranulation, Viral carcinogenesis - Homo sapiens (human)
UniProt: Q5T4S7
Entrez ID: 23352
|
Does Knockout of DNAH12 in Cancer Cell Line causally result in cell proliferation?
| 0
| 1,308
|
Knockout
|
DNAH12
|
cell proliferation
|
Cancer Cell Line
|
Gene: DNAH12 (dynein axonemal heavy chain 12)
Type: protein-coding
Summary: Predicted to enable several functions, including ATP binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of dynein complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: axonemal dynein complex assembly, cilium movement, microtubule-based movement; MF: ATP binding, dynein intermediate chain binding, dynein light intermediate chain binding, minus-end-directed microtubule motor activity, nucleotide binding; CC: axonemal dynein complex, cell projection, cilium, cytoplasm, cytoskeleton, dynein complex, microtubule
Pathways: Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
UniProt: Q6ZR08
Entrez ID: 201625
|
Does Knockout of LONP2 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
LONP2
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: LONP2 (lon peptidase 2, peroxisomal)
Type: protein-coding
Summary: In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017].
Gene Ontology: BP: peroxisome organization, protein catabolic process, protein import into peroxisome matrix, protein processing, protein quality control for misfolded or incompletely synthesized proteins, protein targeting to peroxisome, proteolysis, regulation of fatty acid beta-oxidation; MF: ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, enzyme binding, hydrolase activity, nucleotide binding, peptidase activity, protease binding, protein binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, cytosol, membrane, nucleus, peroxisomal matrix, peroxisome
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, IL-18 signaling pathway, Metabolism of proteins, Peroxisomal protein import, Protein folding, Protein localization
UniProt: Q86WA8
Entrez ID: 83752
|
Does Knockout of COA6 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
COA6
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: COA6 (cytochrome c oxidase assembly factor 6)
Type: protein-coding
Summary: This gene encodes a member of the cytochrome c oxidase subunit 6B family. The encoded protein associates with cytochrome c oxidase may act has an cytochrome c oxidase mitochondrial respiratory complex VI assembly factor. Mutations in this gene may be associated with fatal infantile cardiomyopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014].
Gene Ontology: BP: mitochondrial cytochrome c oxidase assembly, respiratory chain complex IV assembly; MF: RNA binding, copper ion binding, protein binding; CC: mitochondrial intermembrane space, mitochondrion, nucleoplasm
Pathways: Mitochondrial CIV Assembly, Mitochondrial protein import, Protein localization, Thermogenesis - Homo sapiens (human)
UniProt: Q5JTJ3
Entrez ID: 388753
|
Does Knockout of PHYKPL in Monocytic Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,978
|
Knockout
|
PHYKPL
|
response to chemicals
|
Monocytic Leukemia Cell Line
|
Gene: PHYKPL (5-phosphohydroxy-L-lysine phospho-lyase)
Type: protein-coding
Summary: This is a nuclear gene encoding a mitochondrial enzyme that catalyzes the conversion of 5-phosphonooxy-L-lysine to ammonia, inorganic phosphate, and 2-aminoadipate semialdehyde. Mutations in this gene may cause phosphohydroxylysinuria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013].
Gene Ontology: MF: identical protein binding, lyase activity, protein binding, pyridoxal phosphate binding, transaminase activity; CC: mitochondrial matrix, mitochondrion
Pathways: Collagen degradation, Degradation of the extracellular matrix, Extracellular matrix organization, Lysine catabolism, Lysine degradation - Homo sapiens (human), Metabolism, Metabolism of amino acids and derivatives
UniProt: Q8IUZ5
Entrez ID: 85007
|
Does Knockout of SELENOK in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,658
|
Knockout
|
SELENOK
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: SELENOK (selenoprotein K)
Type: protein-coding
Summary: The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017].
Gene Ontology: BP: T cell migration, T cell proliferation, calcium ion transport, endoplasmic reticulum calcium ion homeostasis, establishment of localization in cell, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, macrophage derived foam cell differentiation, monoatomic ion transport, neutrophil migration, positive regulation of T cell migration, positive regulation of T cell proliferation, positive regulation of chemokine production, positive regulation of defense response to virus by host, positive regulation of interleukin-6 production, positive regulation of monocyte chemotactic protein-1 production, positive regulation of neutrophil migration, positive regulation of tumor necrosis factor production, protein palmitoylation, regulation of calcium-mediated signaling, regulation of protein transport, respiratory burst after phagocytosis, response to oxidative stress; MF: identical protein binding, protein binding; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Selenium Micronutrient Network
UniProt: Q9Y6D0
Entrez ID: 58515
|
Does Knockout of C2CD4A in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
C2CD4A
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: C2CD4A (C2 calcium dependent domain containing 4A)
Type: protein-coding
Summary: Involved in positive regulation of acute inflammatory response; regulation of cell adhesion; and regulation of vascular permeability involved in acute inflammatory response. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of acute inflammatory response, regulation of cell adhesion, regulation of vascular permeability involved in acute inflammatory response; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8NCU7
Entrez ID: 145741
|
Does Inhibition of GTF2H5 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,184
|
Inhibition
|
GTF2H5
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GTF2H5 (general transcription factor IIH subunit 5)
Type: protein-coding
Summary: This gene encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protein stimulates ERCC3/XPB ATPase activity to trigger DNA opening during DNA repair, and is implicated in regulating cellular levels of TFIIH. Mutations in this gene result in trichothiodystrophy, complementation group A. [provided by RefSeq, Mar 2009].
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to gamma radiation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), nucleotide-excision repair, nucleotide-excision repair, preincision complex assembly, transcription by RNA polymerase II, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase II promoter; CC: cytoplasm, nucleolus, nucleoplasm, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Homo sapiens (human), DNA Repair, DNA Repair Pathways Full Network, Disease, Dual Incision in GG-NER, Dual incision in TC-NER, Epigenetic regulation of gene expression, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral Infection Pathways, mRNA Capping
UniProt: Q6ZYL4
Entrez ID: 404672
|
Does Knockout of TNFRSF21 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 0
| 2,114
|
Knockout
|
TNFRSF21
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: TNFRSF21 (TNF receptor superfamily member 21)
Type: protein-coding
Summary: This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013].
Gene Ontology: BP: B cell apoptotic process, T cell receptor signaling pathway, adaptive immune response, apoptotic process, axonal fasciculation, cellular response to tumor necrosis factor, humoral immune response, immune system process, myelination, negative regulation of B cell proliferation, negative regulation of T cell proliferation, negative regulation of interleukin-10 production, negative regulation of interleukin-13 production, negative regulation of interleukin-5 production, negative regulation of myelination, neuron apoptotic process, oligodendrocyte apoptotic process, regulation of oligodendrocyte differentiation, signal transduction; CC: membrane, plasma membrane
Pathways: Apoptosis, Apoptosis-related network due to altered Notch3 in ovarian cancer, Cytokine-cytokine receptor interaction - Homo sapiens (human), Metabolism, Metabolism of lipids, PPARA activates gene expression, Regulation of lipid metabolism by PPARalpha
UniProt: O75509
Entrez ID: 27242
|
Does Knockout of GCLC in Non-Small Cell Lung Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 1,391
|
Knockout
|
GCLC
|
response to chemicals
|
Non-Small Cell Lung Adenocarcinoma Cell Line
|
Gene: GCLC (glutamate-cysteine ligase catalytic subunit)
Type: protein-coding
Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010].
Gene Ontology: BP: L-ascorbic acid metabolic process, blood vessel diameter maintenance, cell redox homeostasis, cellular response to fibroblast growth factor stimulus, cellular response to follicle-stimulating hormone stimulus, cellular response to glucose stimulus, cellular response to hepatocyte growth factor stimulus, cellular response to insulin stimulus, cellular response to mechanical stimulus, cellular response to thyroxine stimulus, cysteine metabolic process, glutamate metabolic process, glutathione biosynthetic process, glutathione metabolic process, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of hepatic stellate cell activation, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, negative regulation of neuron apoptotic process, negative regulation of protein ubiquitination, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of mitochondrial depolarization, response to activity, response to arsenic-containing substance, response to cadmium ion, response to heat, response to hormone, response to human chorionic gonadotropin, response to interleukin-1, response to nitrosative stress, response to nutrient, response to oxidative stress, response to xenobiotic stimulus; MF: ADP binding, ATP binding, catalytic activity, glutamate binding, glutamate-cysteine ligase activity, ligase activity, magnesium ion binding, nucleotide binding, protein binding, protein-containing complex binding; CC: cytosol, glutamate-cysteine ligase complex, mitochondrion
Pathways: γ-glutamyl cycle, 2-Hydroxyglutric Aciduria (D And L Form), 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, 5-Oxoprolinuria, 5-oxoprolinase deficiency, Apoptosis-related network due to altered Notch3 in ovarian cancer, Aryl Hydrocarbon Receptor Netpath, Beta-mercaptolactate-cysteine disulfiduria, Biological oxidations, Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cysteine Metabolism, Cysteine and methionine metabolism - Homo sapiens (human), Cystinosis, ocular nonnephropathic, Defective GCLC causes HAGGSD, Disease, Diseases of metabolism, Ferroptosis, Ferroptosis - Homo sapiens (human), Gamma-Glutamyltransferase Deficiency, Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases, Gamma-glutamyl-transpeptidase deficiency, Glutamate Metabolism, Glutathione Metabolism, Glutathione Synthetase Deficiency, Glutathione conjugation, Glutathione metabolism, Glutathione metabolism - Homo sapiens (human), Glutathione synthesis and recycling, Homocarnosinosis, Hyperinsulinism-Hyperammonemia Syndrome, KEAP1-NFE2L2 pathway, Metabolic disorders of biological oxidation enzymes, Metabolism, NFE2L2 regulating anti-oxidant/detoxification enzymes, NRF2 pathway, NRF2-ARE regulation, Nuclear Receptors Meta-Pathway, Nuclear events mediated by NFE2L2, One-carbon metabolism and related pathways, Oxidative Stress, Phase II - Conjugation of compounds, Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling, Phytochemical activity on NRF2 transcriptional activation, Succinic semialdehyde dehydrogenase deficiency, Trans-sulfuration and one-carbon metabolism, Vitamin D-sensitive calcium signaling in depression, glutathione biosynthesis
UniProt: P48506
Entrez ID: 2729
|
Does Knockout of NIPSNAP2 in Cervical Adenocarcinoma Cell Line causally result in protein/peptide accumulation?
| 0
| 2,404
|
Knockout
|
NIPSNAP2
|
protein/peptide accumulation
|
Cervical Adenocarcinoma Cell Line
|
Gene: NIPSNAP2 (nipsnap homolog 2)
Type: protein-coding
Summary: This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. The encoded protein is localized to mitochondria and plays a role in oxidative phosphorylation. A pseudogene of this gene is located on the long arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: autophagy, mitochondrion organization, mitophagy, positive regulation of high voltage-gated calcium channel activity; MF: protein binding, protein-macromolecule adaptor activity; CC: mitochondrial matrix, mitochondrial outer membrane, mitochondrion
Pathways: RHO GTPase cycle, RHOH GTPase cycle, RHOJ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O75323
Entrez ID: 2631
|
Does Knockout of WDR75 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
WDR75
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: WDR75 (WD repeat domain 75)
Type: protein-coding
Summary: Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding, protein binding; CC: nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Homo sapiens (human), rRNA modification in the nucleus and cytosol, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q8IWA0
Entrez ID: 84128
|
Does Knockout of DHX33 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
DHX33
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: DHX33 (DEAH-box helicase 33)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. The DEAD box proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010].
Gene Ontology: BP: positive regulation of MAPK cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of NLRP3 inflammasome complex assembly, positive regulation of transcription by RNA polymerase I, positive regulation of type I interferon production, translational initiation; MF: ATP binding, ATP hydrolysis activity, DNA-binding transcription factor binding, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding, rDNA binding, ribosomal large subunit binding; CC: NLRP3 inflammasome complex, canonical inflammasome complex, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways: NOD-like receptor signaling pathway - Homo sapiens (human)
UniProt: Q9H6R0
Entrez ID: 56919
|
Does Knockout of PFKFB2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 427
|
Knockout
|
PFKFB2
|
cell proliferation
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2)
Type: protein-coding
Summary: The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: carbohydrate phosphorylation, fructose 2,6-bisphosphate metabolic process, fructose metabolic process, gluconeogenesis, glucose catabolic process, glycolytic process, lactate metabolic process, positive regulation of insulin secretion, response to glucose; MF: 6-phosphofructo-2-kinase activity, ATP binding, catalytic activity, fructose-2,6-bisphosphate 2-phosphatase activity, hydrolase activity, kinase activity, kinase binding, nucleotide binding, protein binding, protein kinase binding, transferase activity; CC: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex, cytosol, nucleoplasm
Pathways: AMPK signaling pathway - Homo sapiens (human), Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, Fructose and mannose metabolism - Homo sapiens (human), Glucose metabolism, Glycolysis, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Regulation of glycolysis by fructose 2,6-bisphosphate metabolism, Thyroid hormone signaling pathway - Homo sapiens (human), Thyroid hormones production and their peripheral downstream signaling effects, fructose 2,6-bisphosphate synthesis
UniProt: O60825
Entrez ID: 5208
|
Does Knockout of CCDC9 in Glioblastoma Cell Line causally result in cell proliferation?
| 1
| 906
|
Knockout
|
CCDC9
|
cell proliferation
|
Glioblastoma Cell Line
|
Gene: CCDC9 (coiled-coil domain containing 9)
Type: protein-coding
Summary: Enables RNA binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: RNA binding, protein binding
Pathways: IL-18 signaling pathway
UniProt: Q9Y3X0
Entrez ID: 26093
|
Does Knockout of KRTAP12-4 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
KRTAP12-4
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: KRTAP12-4 (keratin associated protein 12-4)
Type: protein-coding
Summary: Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, intermediate filament
Pathways: Developmental Biology, Keratinization
UniProt: P60329
Entrez ID: 386684
|
Does Knockout of GTF2H1 in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
GTF2H1
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: GTF2H1 (general transcription factor IIH subunit 1)
Type: protein-coding
Summary: Enables thyroid hormone receptor binding activity. Involved in positive regulation of transcription, DNA-templated and transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor TFIIH core complex and transcription factor TFIIH holo complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, hormone-mediated signaling pathway, nucleotide-excision repair, positive regulation of DNA-templated transcription, regulation of cyclin-dependent protein serine/threonine kinase activity, transcription by RNA polymerase I, transcription by RNA polymerase II, transcription initiation at RNA polymerase II promoter; MF: chromatin binding, nuclear thyroid hormone receptor binding, protein binding; CC: nucleoplasm, nucleus, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: AndrogenReceptor, Basal transcription factors - Homo sapiens (human), DNA Repair, DNA Repair Pathways Full Network, Disease, Dual Incision in GG-NER, Dual incision in TC-NER, Epigenetic regulation of gene expression, Eukaryotic Transcription Initiation, Formation of HIV elongation complex in the absence of HIV Tat, Formation of HIV-1 elongation complex containing HIV-1 Tat, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Formation of the HIV-1 Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HIV Infection, HIV Life Cycle, HIV Transcription Elongation, HIV Transcription Initiation, Infectious disease, Late Phase of HIV Life Cycle, Metabolism of RNA, Negative epigenetic regulation of rRNA expression, NoRC negatively regulates rRNA expression, Nucleotide Excision Repair, Nucleotide excision repair - Homo sapiens (human), RNA Pol II CTD phosphorylation and interaction with CE, RNA Pol II CTD phosphorylation and interaction with CE during HIV infection, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II HIV Promoter Escape, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Tat-mediated elongation of the HIV-1 transcript, Transcription of the HIV genome, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral Infection Pathways, Viral carcinogenesis - Homo sapiens (human), mRNA Capping
UniProt: P32780
Entrez ID: 2965
|
Does Knockout of IGBP1 in acute lymphoblastic leukemia cell line causally result in cell proliferation?
| 1
| 1,957
|
Knockout
|
IGBP1
|
cell proliferation
|
acute lymphoblastic leukemia cell line
|
Gene: IGBP1 (immunoglobulin binding protein 1)
Type: protein-coding
Summary: The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: B cell activation, intracellular signal transduction, negative regulation of stress-activated MAPK cascade, negative regulation of transcription by RNA polymerase II, regulation of dephosphorylation, regulation of microtubule-based movement, regulation of signal transduction, response to interleukin-1, response to tumor necrosis factor, signal transduction; MF: protein binding, protein phosphatase 2A binding, protein phosphatase regulator activity; CC: cytoplasm, cytosol
Pathways: 16p11.2 proximal deletion syndrome, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human)
UniProt: P78318
Entrez ID: 3476
|
Does Knockout of SAMM50 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
SAMM50
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: SAMM50 (SAMM50 sorting and assembly machinery component)
Type: protein-coding
Summary: This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011].
Gene Ontology: BP: cristae formation, inner mitochondrial membrane organization, protein import into mitochondrial matrix, protein insertion into mitochondrial outer membrane; CC: MIB complex, SAM complex, cytoplasm, extracellular exosome, membrane, mitochondrial outer membrane, mitochondrion, outer membrane
Pathways: Cristae formation, Mitochondrial biogenesis, Mitochondrial protein import, Organelle biogenesis and maintenance, Protein localization, RAC2 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9Y512
Entrez ID: 25813
|
Does Knockout of PSMA7 in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
PSMA7
|
cell proliferation
|
Bladder Carcinoma
|
Gene: PSMA7 (proteasome 20S subunit alpha 7)
Type: protein-coding
Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: identical protein binding, protein binding; CC: cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Huntington disease - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), proteasome complex, y branching of actin filaments
UniProt: O14818
Entrez ID: 5688
|
Does Knockout of BCAT1 in Medulloblastoma Cell Line causally result in cell proliferation?
| 0
| 408
|
Knockout
|
BCAT1
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: BCAT1 (branched chain amino acid transaminase 1)
Type: protein-coding
Summary: This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010].
Gene Ontology: BP: G1/S transition of mitotic cell cycle, amino acid biosynthetic process, branched-chain amino acid biosynthetic process, branched-chain amino acid catabolic process, branched-chain amino acid metabolic process, lipid metabolic process; MF: L-isoleucine-2-oxoglutarate transaminase activity, L-leucine-2-oxoglutarate transaminase activity, L-valine-2-oxoglutarate transaminase activity, branched-chain-amino-acid transaminase activity, catalytic activity, protein binding, transaminase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: 2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency, 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency, 3-Methylcrotonyl Coa Carboxylase Deficiency Type I, 3-Methylglutaconic Aciduria Type I, 3-Methylglutaconic Aciduria Type III, 3-Methylglutaconic Aciduria Type IV, 3-hydroxyisobutyric acid dehydrogenase deficiency, 3-hydroxyisobutyric aciduria, Amino Acid metabolism, Beta-Ketothiolase Deficiency, Cysteine and methionine metabolism - Homo sapiens (human), Isobutyryl-coa dehydrogenase deficiency, Isovaleric Aciduria, Isovaleric acidemia, Maple Syrup Urine Disease, Methylmalonate Semialdehyde Dehydrogenase Deficiency, Methylmalonic Aciduria, One-carbon metabolism and related pathways, Pantothenate and CoA biosynthesis - Homo sapiens (human), Propionic Acidemia, Validated targets of C-MYC transcriptional activation, Valine, Leucine and Isoleucine Degradation, Valine, leucine and isoleucine biosynthesis - Homo sapiens (human), Valine, leucine and isoleucine degradation - Homo sapiens (human), isoleucine degradation, leucine degradation, valine degradation
UniProt: P54687
Entrez ID: 586
|
Does Knockout of SRF in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 220
|
Knockout
|
SRF
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: SRF (serum response factor)
Type: protein-coding
Summary: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
Gene Ontology: BP: actin cytoskeleton organization, actin filament organization, angiogenesis involved in wound healing, associative learning, axon extension, bicellular tight junction assembly, branching involved in blood vessel morphogenesis, bronchus cartilage development, cardiac muscle cell myoblast differentiation, cardiac myofibril assembly, cardiac vascular smooth muscle cell differentiation, cell migration involved in sprouting angiogenesis, cell-cell adhesion, cell-matrix adhesion, cellular response to glucose stimulus, cellular senescence, contractile actin filament bundle assembly, developmental growth, dorsal aorta morphogenesis, epithelial cell-cell adhesion, epithelial structure maintenance, erythrocyte development, establishment of skin barrier, eyelid development in camera-type eye, face development, filopodium assembly, forebrain development, gastrulation, heart development, heart looping, heart trabecula formation, hematopoietic stem cell differentiation, hippocampus development, in utero embryonic development, leukocyte differentiation, long-term memory, long-term synaptic depression, lung morphogenesis, lung smooth muscle development, megakaryocyte development, mesoderm formation, morphogenesis of an epithelial sheet, muscle cell cellular homeostasis, negative regulation of amyloid-beta clearance, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of miRNA transcription, neuron development, neuron migration, neuron projection development, platelet activation, platelet formation, positive regulation of DNA-binding transcription factor activity, positive regulation of DNA-templated transcription, positive regulation of axon extension, positive regulation of cell differentiation, positive regulation of filopodium assembly, positive regulation of miRNA transcription, positive regulation of smooth muscle contraction, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by glucose, positive regulation of transcription initiation by RNA polymerase II, positive thymic T cell selection, primitive streak formation, regulation of DNA-templated transcription, regulation of cell adhesion, regulation of smooth muscle cell differentiation, response to cytokine, response to hormone, response to hypoxia, response to toxic substance, sarcomere organization, skin morphogenesis, stress fiber assembly, tangential migration from the subventricular zone to the olfactory bulb, thymus development, thyroid gland development, trachea cartilage development, transcription by RNA polymerase II, trophectodermal cell differentiation, wound healing; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, cis-regulatory region sequence-specific DNA binding, histone deacetylase binding, primary miRNA binding, protein binding, protein dimerization activity, protein homodimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, serum response element binding; CC: chromatin, cytoplasm, nucleoplasm, nucleus
Pathways: 22q11.2 copy number variation syndrome, Cardiogenesis, Cell Differentiation - Index, Cell Differentiation - Index expanded, Coregulation of Androgen receptor activity, Developmental Biology, ESR-mediated signaling, Envelope proteins and their potential roles in EDMD physiopathology, ErbB1 downstream signaling, Estrogen-dependent nuclear events downstream of ESR-membrane signaling, Extra-nuclear estrogen signaling, Gene expression (Transcription), Generic Transcription Pathway, Genes targeted by miRNAs in adipocytes, Heart Development, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Insulin Signaling, MAPK Signaling Pathway, MAPK signaling pathway - Homo sapiens (human), Mesodermal commitment pathway, NGF-stimulated transcription, Nuclear Events (kinase and transcription factor activation), PDGFR-alpha signaling pathway, PDGFR-beta signaling pathway, RHO GTPase Effectors, RHO GTPases Activate Formins, RNA Polymerase II Transcription, Regulation of NPAS4 gene expression, Regulation of NPAS4 gene transcription, RhoA signaling pathway, SRF and miRs in Smooth Muscle Differentiation and Proliferation, Serotonin Receptor 2 and ELK-SRF-GATA4 signaling, Serotonin Receptor 4-6-7 and NR3C Signaling, Signal Transduction, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Nuclear Receptors, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling events mediated by HDAC Class II, Transcriptional Regulation by NPAS4, Trk receptor signaling mediated by the MAPK pathway, VEGFA-VEGFR2 Signaling Pathway, Viral carcinogenesis - Homo sapiens (human), cGMP-PKG signaling pathway - Homo sapiens (human), growth hormone signaling pathway, hop pathway in cardiac development, igf-1 signaling pathway, p38 signaling mediated by MAPKAP kinases, pdgf signaling pathway, role of mal in rho-mediated activation of srf
UniProt: P11831
Entrez ID: 6722
|
Does Knockout of ATP6V0C in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
ATP6V0C
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: ATP6V0C (ATPase H+ transporting V0 subunit c)
Type: protein-coding
Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. [provided by RefSeq, Nov 2010].
Gene Ontology: BP: Golgi lumen acidification, endosomal lumen acidification, intracellular pH reduction, lysosomal lumen acidification, monoatomic ion transport, positive regulation of Wnt signaling pathway, proton motive force-driven ATP synthesis, proton transmembrane transport, regulation of macroautophagy, synaptic vesicle lumen acidification, vacuolar acidification; MF: protein binding, proton transmembrane transporter activity, proton-transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism, ubiquitin protein ligase binding; CC: Golgi membrane, azurophil granule membrane, bounding membrane of organelle, clathrin-coated vesicle membrane, cytoplasmic vesicle, endosome membrane, extracellular exosome, ficolin-1-rich granule membrane, focal adhesion, lysosomal membrane, membrane, phagocytic vesicle membrane, plasma membrane, proton-transporting V-type ATPase complex, proton-transporting V-type ATPase, V0 domain, proton-transporting two-sector ATPase complex, proton-transporting domain, synapse, synaptic vesicle membrane, tertiary granule membrane, vacuolar proton-transporting V-type ATPase, V0 domain
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Collecting duct acid secretion - Homo sapiens (human), Developmental Biology, Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human), Human papillomavirus infection - Homo sapiens (human), Immune System, Innate Immune System, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Lysosome - Homo sapiens (human), MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Neutrophil degranulation, Oxidative phosphorylation - Homo sapiens (human), Phagosome - Homo sapiens (human), Proximal tubule transport, ROS and RNS production in phagocytes, Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy, Rheumatoid arthritis - Homo sapiens (human), Signal Transduction, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Synaptic vesicle cycle - Homo sapiens (human), Transferrin endocytosis and recycling, Transport of small molecules, Tuberculosis - Homo sapiens (human), Vibrio cholerae infection - Homo sapiens (human), adenosine ribonucleotides <i>de novo</i> biosynthesis, purine nucleotides <i>de novo</i> biosynthesis, superpathway of purine nucleotide salvage
UniProt: P27449
Entrez ID: 527
|
Does Knockout of ZWINT in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
ZWINT
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: ZWINT (ZW10 interacting kinetochore protein)
Type: protein-coding
Summary: This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell division, establishment of localization in cell, homologous chromosome orientation in meiotic metaphase I, mitotic sister chromatid segregation, mitotic spindle assembly checkpoint signaling, regulation of meiosis I spindle assembly checkpoint; CC: Knl1/Spc105 complex, chromosome, chromosome, centromeric region, cytoplasm, cytosol, dendrite, kinetochore, nuclear body, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O95229
Entrez ID: 11130
|
Does Knockout of SNRNP35 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
SNRNP35
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: SNRNP35 (small nuclear ribonucleoprotein U11/U12 subunit 35)
Type: protein-coding
Summary: The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013].
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, mRNA binding, nucleic acid binding, protein binding, snRNA binding; CC: U12-type spliceosomal complex, nucleolus, nucleoplasm, nucleus, ribonucleoprotein complex, spliceosomal complex
Pathways:
UniProt: Q16560
Entrez ID: 11066
|
Does Knockout of PSMA3 in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
PSMA3
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: PSMA3 (proteasome 20S subunit alpha 3)
Type: protein-coding
Summary: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis involved in protein catabolic process, ubiquitin-dependent protein catabolic process; MF: protein binding, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus, proteasome complex, proteasome core complex, proteasome core complex, alpha-subunit complex
Pathways: Alzheimer disease - Homo sapiens (human), Amyotrophic lateral sclerosis - Homo sapiens (human), Aurora B signaling, Huntington disease - Homo sapiens (human), Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Prion disease - Homo sapiens (human), Proteasome - Homo sapiens (human), Proteasome Degradation, Spinocerebellar ataxia - Homo sapiens (human), proteasome complex
UniProt: P25788
Entrez ID: 5684
|
Does Knockout of LGALS3BP in T-lymphoma cell line causally result in cell proliferation?
| 0
| 478
|
Knockout
|
LGALS3BP
|
cell proliferation
|
T-lymphoma cell line
|
Gene: LGALS3BP (galectin 3 binding protein)
Type: protein-coding
Summary: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, cellular defense response, signal transduction, vesicle-mediated transport; MF: protein binding, scavenger receptor activity; CC: blood microparticle, extracellular exosome, extracellular matrix, extracellular region, extracellular space, membrane, platelet dense granule lumen
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q08380
Entrez ID: 3959
|
Does Knockout of MEMO1 in Prostate Cancer Cell Line causally result in response to chemicals?
| 1
| 2,109
|
Knockout
|
MEMO1
|
response to chemicals
|
Prostate Cancer Cell Line
|
Gene: MEMO1 (mediator of cell motility 1)
Type: protein-coding
Summary: Involved in regulation of microtubule-based process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytosol, nucleus
Pathways: ERBB2 Regulates Cell Motility, Signal Transduction, Signaling by ERBB2, Signaling by Receptor Tyrosine Kinases
UniProt: Q9Y316
Entrez ID: 51072
|
Does Knockout of MCM4 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
MCM4
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: MCM4 (minichromosome maintenance complex component 4)
Type: protein-coding
Summary: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA replication, DNA replication initiation, DNA strand elongation involved in DNA replication, double-strand break repair via break-induced replication, mitotic DNA replication initiation, regulation of DNA-templated DNA replication initiation; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA helicase activity, helicase activity, hydrolase activity, nucleotide binding, protein binding, single-stranded DNA binding, single-stranded DNA helicase activity; CC: CMG complex, MCM complex, chromosome, chromosome, telomeric region, membrane, nucleoplasm, nucleus
Pathways: Activation of ATR in response to replication stress, Activation of the pre-replicative complex, Assembly of the pre-replicative complex, C-MYB transcription factor network, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Ciliary landscape, DNA Replication, DNA Replication Pre-Initiation, DNA replication - Homo sapiens (human), DNA strand elongation, G1 to S cell cycle control, G1/S Transition, G2/M Checkpoints, Gastric Cancer Network 1, Mitotic G1 phase and G1/S transition, Orc1 removal from chromatin, Retinoblastoma gene in cancer, S Phase, Switching of origins to a post-replicative state, Synthesis of DNA, Unwinding of DNA, cdk regulation of dna replication
UniProt: P33991
Entrez ID: 4173
|
Does Knockout of BTRC in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
BTRC
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: BTRC (beta-transducin repeat containing E3 ubiquitin protein ligase)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, T cell receptor signaling pathway, TORC1 signaling, Wnt signaling pathway, autophagosome assembly, branching involved in mammary gland duct morphogenesis, cellular response to nutrient levels, lysosome organization, mammary gland epithelial cell proliferation, negative regulation of T cell receptor signaling pathway, negative regulation of TORC1 signaling, negative regulation of autophagy, negative regulation of smoothened signaling pathway, negative regulation of transcription by RNA polymerase II, non-canonical NF-kappaB signal transduction, positive regulation of DNA-templated transcription, positive regulation of T cell receptor signaling pathway, positive regulation of autophagy, positive regulation of circadian rhythm, positive regulation of proteolysis, proteasome-mediated ubiquitin-dependent protein catabolic process, protein K48-linked ubiquitination, protein K63-linked ubiquitination, protein catabolic process, protein dephosphorylation, protein destabilization, protein polyubiquitination, protein ubiquitination, regulation of canonical NF-kappaB signal transduction, regulation of canonical Wnt signaling pathway, regulation of cell cycle, regulation of circadian rhythm, regulation of proteasomal protein catabolic process, rhythmic process, signal transduction, ubiquitin-dependent protein catabolic process; MF: beta-catenin binding, ligase activity, protein binding, protein dimerization activity, protein phosphorylated amino acid binding, ubiquitin ligase activator activity, ubiquitin protein ligase activity, ubiquitin-like ligase-substrate adaptor activity; CC: SCF ubiquitin ligase complex, cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Alternative NF-kappaB pathway, Atypical NF-kappaB pathway, Canonical NF-kappaB pathway, Cellular senescence - Homo sapiens (human), Circadian rhythm - Homo sapiens (human), Degradation of beta catenin, Hedgehog signaling events mediated by Gli proteins, Hedgehog signaling pathway - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Presenilin action in Notch and Wnt signaling, Prolactin, Regulation of nuclear beta catenin signaling and target gene transcription, Shigellosis - Homo sapiens (human), Signaling events mediated by HDAC Class I, TGF-beta Signaling Pathway, TGF_beta_Receptor, TNF-alpha signaling pathway, TNFalpha, Ubiquitin mediated proteolysis - Homo sapiens (human), Validated transcriptional targets of TAp63 isoforms, Wnt signaling pathway - Homo sapiens (human), inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages, wnt signaling pathway
UniProt: Q9Y297
Entrez ID: 8945
|
Does Knockout of TTK in Urinary Bladder Cancer Cell Line causally result in cell proliferation?
| 1
| 180
|
Knockout
|
TTK
|
cell proliferation
|
Urinary Bladder Cancer Cell Line
|
Gene: TTK (TTK protein kinase)
Type: protein-coding
Summary: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].
Gene Ontology: BP: chromosome segregation, female meiosis chromosome segregation, meiotic spindle assembly checkpoint signaling, mitotic spindle assembly checkpoint signaling, mitotic spindle organization, nuclear chromosome segregation, nuclear division, positive regulation of SMAD protein signal transduction, positive regulation of cell population proliferation, protein localization to chromosome, protein localization to kinetochore, protein localization to meiotic spindle midzone, repair of mitotic kinetochore microtubule attachment defect, spindle organization; MF: ATP binding, identical protein binding, kinase activity, kinetochore binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, protein tyrosine kinase activity, transferase activity; CC: cytoplasm, kinetochore, membrane, nucleus, spindle
Pathways: Cell cycle, Cell cycle - Homo sapiens (human), Retinoblastoma gene in cancer
UniProt: P33981
Entrez ID: 7272
|
Does Knockout of RINT1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
RINT1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: RINT1 (RAD50 interactor 1)
Type: protein-coding
Summary: This gene encodes a protein first identified for its ability to interact with the RAD50 double strand break repair protein, with the resulting interaction implicated in the regulation of cell cycle progression and telomere length. The encoded protein may also play a role in trafficking of cellular cargo from the endosome to the trans-Golgi network. Mutations in this gene may be associated with breast cancer in human patients. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, mitotic G2 DNA damage checkpoint signaling, protein transport, regulation of ER to Golgi vesicle-mediated transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; CC: Dsl1/NZR complex, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q6NUQ1
Entrez ID: 60561
|
Does Activation of LONRF3 in Hepatoma Cell Line causally result in response to virus?
| 1
| 1,210
|
Activation
|
LONRF3
|
response to virus
|
Hepatoma Cell Line
|
Gene: LONRF3 (LON peptidase N-terminal domain and ring finger 3)
Type: protein-coding
Summary: The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants have been suggested, but their full length natures are not clear. [provided by RefSeq, Jul 2008].
Gene Ontology: MF: metal ion binding, protein binding, zinc ion binding
Pathways:
UniProt: Q496Y0
Entrez ID: 79836
|
Does Knockout of PLEKHM1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
PLEKHM1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: PLEKHM1 (pleckstrin homology and RUN domain containing M1)
Type: protein-coding
Summary: The protein encoded by this gene is essential for bone resorption, and may play a critical role in vesicular transport in the osteoclast. Mutations in this gene are associated with autosomal recessive osteopetrosis type 6 (OPTB6). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: autophagosome-lysosome fusion, autophagy, late endosome to lysosome transport, lysosome localization, positive regulation of bone resorption, positive regulation of ruffle assembly, protein transport; MF: metal ion binding, protein binding, zinc ion binding; CC: autolysosome, autolysosome membrane, cytoplasmic vesicle, endosome, endosome membrane, late endosome membrane, lysosomal membrane, lysosome, membrane, nucleolus, nucleoplasm
Pathways: Autosomal recessive Osteopetrosis pathways, Salmonella infection - Homo sapiens (human)
UniProt: Q9Y4G2
Entrez ID: 9842
|
Does Knockout of NKTR in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 0
| 734
|
Knockout
|
NKTR
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: NKTR (natural killer cell triggering receptor)
Type: protein-coding
Summary: This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: protein folding; MF: cyclosporin A binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity; CC: cytoplasm, membrane, nucleus, plasma membrane
Pathways:
UniProt: P30414
Entrez ID: 4820
|
Does Knockout of ZSCAN20 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
ZSCAN20
|
cell proliferation
|
Cancer Cell Line
|
Gene: ZSCAN20 (zinc finger and SCAN domain containing 20)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific double-stranded DNA binding, zinc ion binding
Pathways:
UniProt: P17040
Entrez ID: 7579
|
Does Knockout of SOX3 in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
SOX3
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: SOX3 (SRY-box transcription factor 3)
Type: protein-coding
Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked cognitive disability with growth hormone deficiency. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: brain development, central nervous system development, face development, hypothalamus development, negative regulation of neuron differentiation, negative regulation of transcription by RNA polymerase II, neuron differentiation, pituitary gland development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, sensory organ development, sex determination; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: chromatin, nucleoplasm, nucleus
Pathways: Deactivation of the beta-catenin transactivating complex, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT
UniProt: P41225
Entrez ID: 6658
|
Does Knockout of CFLAR in Large Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 734
|
Knockout
|
CFLAR
|
cell proliferation
|
Large Cell Lung Cancer Cell Line
|
Gene: CFLAR (CASP8 and FADD like apoptosis regulator)
Type: protein-coding
Summary: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011].
Gene Ontology: BP: apoptotic process, cellular response to dexamethasone stimulus, cellular response to epidermal growth factor stimulus, cellular response to estradiol stimulus, cellular response to hypoxia, cellular response to insulin stimulus, cellular response to nitric oxide, extrinsic apoptotic signaling pathway via death domain receptors, macrophage differentiation, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cellular response to transforming growth factor beta stimulus, negative regulation of epithelial cell apoptotic process, negative regulation of extrinsic apoptotic signaling pathway, negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, negative regulation of hepatocyte apoptotic process, negative regulation of myoblast fusion, negative regulation of reactive oxygen species biosynthetic process, positive regulation of ERK1 and ERK2 cascade, positive regulation of canonical NF-kappaB signal transduction, positive regulation of extracellular matrix organization, positive regulation of glomerular mesangial cell proliferation, positive regulation of hepatocyte proliferation, positive regulation of neuron apoptotic process, positive regulation of neuron projection development, proteolysis, regulation of apoptotic process, regulation of necroptotic process, regulation of skeletal muscle satellite cell proliferation, response to hypoxia, response to testosterone, skeletal muscle atrophy, skeletal muscle tissue development, skeletal muscle tissue regeneration, skeletal myofibril assembly; MF: cysteine-type endopeptidase activity, cysteine-type peptidase activity, death receptor binding, enzyme activator activity, protease binding, protein binding, protein-containing complex binding; CC: CD95 death-inducing signaling complex, cytoplasm, cytosol, death-inducing signaling complex, ripoptosome
Pathways: Apoptosis, Apoptosis - Homo sapiens (human), Apoptosis Modulation and Signaling, Autophagy - animal - Homo sapiens (human), Chagas disease - Homo sapiens (human), FAS (CD95) signaling pathway, Fas ligand pathway and stress induction of heat shock proteins, HIV-1 Nef: Negative effector of Fas and TNF-alpha, Hepatitis C - Homo sapiens (human), IL-18 signaling pathway, NF-kappa B signaling pathway - Homo sapiens (human), Nanomaterial induced apoptosis, Necroptosis - Homo sapiens (human), Photodynamic therapy-induced NF-kB survival signaling, TNF signaling pathway - Homo sapiens (human), TNF-alpha signaling pathway, TNFalpha, TRAIL signaling pathway, Validated targets of C-MYC transcriptional repression, fas signaling pathway (cd95), hiv-1 nef: negative effector of fas and tnf
UniProt: O15519
Entrez ID: 8837
|
Does Knockout of SLC25A34 in Hepatoma Cell Line causally result in cell proliferation?
| 0
| 1,206
|
Knockout
|
SLC25A34
|
cell proliferation
|
Hepatoma Cell Line
|
Gene: SLC25A34 (solute carrier family 25 member 34)
Type: protein-coding
Summary: SLC25A34 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008].
Gene Ontology: CC: membrane, mitochondrial inner membrane, mitochondrion
Pathways:
UniProt: Q6PIV7
Entrez ID: 284723
|
Does Knockout of CAPSL in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
CAPSL
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: CAPSL (calcyphosine like)
Type: protein-coding
Summary: Predicted to enable calcium ion binding activity. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: calcium ion binding, metal ion binding; CC: cytoplasm, organelle
Pathways:
UniProt: Q8WWF8
Entrez ID: 133690
|
Does Knockout of UBA52 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
UBA52
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: UBA52 (ubiquitin A-52 residue ribosomal protein fusion product 1)
Type: protein-coding
Summary: Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cytoplasmic translation, modification-dependent protein catabolic process, protein modification process, protein ubiquitination, response to insecticide, translation; MF: protein binding, protein tag activity, structural constituent of ribosome, ubiquitin protein ligase binding; CC: cytoplasm, cytosol, cytosolic large ribosomal subunit, cytosolic ribosome, endocytic vesicle membrane, endoplasmic reticulum membrane, endosome membrane, extracellular exosome, extracellular space, large ribosomal subunit, lysosomal membrane, mitochondrial outer membrane, nucleoplasm, nucleus, plasma membrane, ribonucleoprotein complex, ribosome, vesicle
Pathways: ABC transporter disorders, ABC-family proteins mediated transport, AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274), APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, AUF1 (hnRNP D0) binds and destabilizes mRNA, Activated NOTCH1 Transmits Signal to the Nucleus, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE), Activation of NF-kappaB in B cells, Adaptive Immune System, Adherens junctions interactions, Aerobic respiration and respiratory electron transport, Aggrephagy, Alpha-protein kinase 1 signaling pathway, Amyloid fiber formation, Antigen processing-Cross presentation, Antigen processing: Ubiquitination & Proteasome degradation, Antiviral mechanism by IFN-stimulated genes, Apoptosis, Asparagine N-linked glycosylation, Assembly Of The HIV Virion, Assembly of the pre-replicative complex, Asymmetric localization of PCP proteins, Autodegradation of Cdh1 by Cdh1:APC/C, Autodegradation of the E3 ubiquitin ligase COP1, Autophagy, Axon guidance, Bacterial Infection Pathways, Beta-catenin independent WNT signaling, Budding and maturation of HIV virion, C-type lectin receptors (CLRs), CDK-mediated phosphorylation and removal of Cdc6, CLEC7A (Dectin-1) signaling, Calnexin/calreticulin cycle, Cap-dependent Translation Initiation, Cargo recognition for clathrin-mediated endocytosis, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell death signalling via NRAGE, NRIF and NADE, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Cellular Senescence, Cellular response to chemical stress, Cellular response to hypoxia, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Chaperone Mediated Autophagy, Circadian clock, Class I MHC mediated antigen processing & presentation, Clathrin-mediated endocytosis, Co-inhibition by PD-1, Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants, Constitutive Signaling by NOTCH1 HD Domain Mutants, Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Coronavirus disease - COVID-19 - Homo sapiens (human), Cyclin A:Cdk2-associated events at S phase entry, Cyclin D associated events in G1, Cyclin E associated events during G1/S transition , Cytokine Signaling in Immune system, Cytoplasmic Ribosomal Proteins, Cytosolic sensors of pathogen-associated DNA , DDX58/IFIH1-mediated induction of interferon-alpha/beta, DNA Damage Bypass, DNA Damage Recognition in GG-NER, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA Replication Pre-Initiation, Deactivation of the beta-catenin transactivating complex, Death Receptor Signaling, Dectin-1 mediated noncanonical NF-kB signaling, Defective CFTR causes cystic fibrosis, Degradation of AXIN, Degradation of CDH1, Degradation of CRY and PER proteins, Degradation of DVL, Degradation of GLI1 by the proteasome, Degradation of GLI2 by the proteasome, Degradation of beta-catenin by the destruction complex, Deubiquitination, Developmental Biology, Disease, Diseases of carbohydrate metabolism, Diseases of metabolism, Diseases of signal transduction by growth factor receptors and second messengers, Disorders of transmembrane transporters, Downregulation of ERBB2 signaling, Downregulation of ERBB2:ERBB3 signaling, Downregulation of ERBB4 signaling, Downregulation of SMAD2/3:SMAD4 transcriptional activity, Downregulation of TGF-beta receptor signaling, Downstream TCR signaling, Downstream signaling events of B Cell Receptor (BCR), Dual Incision in GG-NER, Dual incision in TC-NER, E3 ubiquitin ligases ubiquitinate target proteins, EGFR downregulation, ER Quality Control Compartment (ERQC), ER-Phagosome pathway, Endosomal Sorting Complex Required For Transport (ESCRT), Eukaryotic Translation Elongation, Eukaryotic Translation Initiation, Eukaryotic Translation Termination, Evasion by RSV of host interferon responses, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis, FCERI mediated NF-kB activation, FLT3 Signaling, FLT3 signaling by CBL mutants, FLT3 signaling in disease, Fanconi Anemia Pathway, Fc epsilon receptor (FCERI) signaling, Formation of Incision Complex in GG-NER, Formation of TC-NER Pre-Incision Complex, Formation of a pool of free 40S subunits, G1 Phase, G1/S DNA Damage Checkpoints, G1/S Transition, G2/M Checkpoints, G2/M Transition, GLI3 is processed to GLI3R by the proteasome, GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2, GSK3B-mediated proteasomal degradation of PD-L1(CD274), GTP hydrolysis and joining of the 60S ribosomal subunit, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Glycogen metabolism, Glycogen storage diseases, Glycogen synthesis, HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HIV Infection, HIV Life Cycle, Hedgehog 'off' state, Hedgehog 'on' state, Hedgehog ligand biogenesis, Hh mutants abrogate ligand secretion, Hh mutants are degraded by ERAD, Homology Directed Repair, Host Interactions of HIV factors, IKK complex recruitment mediated by RIP1, IRAK1 recruits IKK complex, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation, IRAK2 mediated activation of TAK1 complex, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation, ISG15 antiviral mechanism, Immune System, Inactivation of CSF3 (G-CSF) signaling, Infection with Mycobacterium tuberculosis, Infectious disease, Influenza Infection, Influenza Viral RNA Transcription and Replication, InlA-mediated entry of Listeria monocytogenes into host cells, InlB-mediated entry of Listeria monocytogenes into host cell, Innate Immune System, Interferon Signaling, Interferon alpha/beta signaling, Interleukin-1 family signaling, Interleukin-1 signaling, Interleukin-17 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, Ion channel transport, Iron uptake and transport, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Josephin domain DUBs, KEAP1-NFE2L2 pathway, Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human), L13a-mediated translational silencing of Ceruloplasmin expression, Late Phase of HIV Life Cycle, Late SARS-CoV-2 Infection Events, Late endosomal microautophagy, Listeria monocytogenes entry into host cells, M Phase, MAP kinase activation, MAP3K8 (TPL2)-dependent MAPK1/3 activation, MAPK family signaling cascades, MAPK1/MAPK3 signaling, MAPK6/MAPK4 signaling, Macroautophagy, Major pathway of rRNA processing in the nucleolus and cytosol, Maturation of protein E, Membrane Trafficking, Membrane binding and targetting of GAG proteins, Metabolism, Metabolism of RNA, Metabolism of amino acids and derivatives, Metabolism of carbohydrates and carbohydrate derivatives, Metabolism of proteins, Metalloprotease DUBs, Mitophagy, Mitophagy - animal - Homo sapiens (human), Mitotic Anaphase, Mitotic G1 phase and G1/S transition, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Modulation by Mtb of host immune system, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Myoclonic epilepsy of Lafora, N-glycan trimming in the ER and Calnexin/Calreticulin cycle, NF-kB is activated and signals survival, NIK-->noncanonical NF-kB signaling, NOD1/2 Signaling Pathway, NOTCH1 Intracellular Domain Regulates Transcription, NOTCH2 Activation and Transmission of Signal to the Nucleus, NOTCH3 Activation and Transmission of Signal to the Nucleus, NRIF signals cell death from the nucleus, Neddylation, Negative regulation of FGFR1 signaling, Negative regulation of FGFR2 signaling, Negative regulation of FGFR3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of FLT3, Negative regulation of MAPK pathway, Negative regulation of MET activity, Negative regulation of NOTCH4 signaling, Negative regulators of DDX58/IFIH1 signaling, Nervous system development, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), Nuclear events mediated by NFE2L2, Nucleotide Excision Repair, Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, Oncogene Induced Senescence, Orc1 removal from chromatin, Ovarian tumor domain proteases, Oxidative Stress Induced Senescence, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, PCP/CE pathway, PD-L1(CD274) glycosylation and translocation to plasma membrane, PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, PINK1-PRKN Mediated Mitophagy, PIP3 activates AKT signaling, PTEN Regulation, PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1, Parkinson disease - Homo sapiens (human), Pathways of neurodegeneration - multiple diseases - Homo sapiens (human), Peptide chain elongation, Peroxisomal protein import, Pexophagy, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Post-translational protein modification, Prevention of phagosomal-lysosomal fusion, Processing of DNA double-strand break ends, Programmed Cell Death, Protein localization, Protein ubiquitination, Pyruvate metabolism, RAF/MAP kinase cascade, RAS processing, RIPK1-mediated regulated necrosis, RNA Polymerase II Transcription, RSV-host interactions, RUNX1 regulates transcription of genes involved in differentiation of HSCs, Recognition of DNA damage by PCNA-containing replication complex, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks, Regulated Necrosis, Regulation of APC/C activators between G1/S and early anaphase, Regulation of Apoptosis, Regulation of BACH1 activity, Regulation of CDH1 Expression and Function, Regulation of CDH1 Function, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of FZD by ubiquitination, Regulation of Homotypic Cell-Cell Adhesion, Regulation of NF-kappa B signaling, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of PLK1 Activity at G2/M Transition, Regulation of PTEN localization, Regulation of PTEN stability and activity, Regulation of RAS by GAPs, Regulation of RUNX2 expression and activity, Regulation of RUNX3 expression and activity, Regulation of T cell activation by CD28 family, Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 , Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation, Regulation of TNFR1 signaling, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Regulation of activated PAK-2p34 by proteasome mediated degradation, Regulation of expression of SLITs and ROBOs, Regulation of innate immune responses to cytosolic DNA, Regulation of mRNA stability by proteins that bind AU-rich elements, Regulation of mitotic cell cycle, Regulation of necroptotic cell death, Regulation of pyruvate metabolism, Regulation of signaling by CBL, Respiratory Syncytial Virus Infection Pathway, Response of EIF2AK4 (GCN2) to amino acid deficiency, Response of Mtb to phagocytosis, Ribosome - Homo sapiens (human), Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide, Ribosome-associated quality control, S Phase, SARS-CoV Infections, SARS-CoV-1 Infection, SARS-CoV-1 activates/modulates innate immune responses, SARS-CoV-1-host interactions, SARS-CoV-2 Infection, SARS-CoV-2 activates/modulates innate and adaptive immune responses, SARS-CoV-2-host interactions, SCF(Skp2)-mediated degradation of p27/p21, SCF-beta-TrCP mediated degradation of Emi1, SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription, SPOP-mediated proteasomal degradation of PD-L1(CD274), SRP-dependent cotranslational protein targeting to membrane, Selective autophagy, Selenoamino acid metabolism, Selenocysteine synthesis, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Shigellosis - Homo sapiens (human), Signal Transduction, Signaling by ALK fusions and activated point mutants, Signaling by ALK in cancer, Signaling by CSF1 (M-CSF) in myeloid cells, Signaling by CSF3 (G-CSF), Signaling by EGFR, Signaling by EGFR in Cancer, Signaling by ERBB2, Signaling by ERBB4, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Hedgehog, Signaling by Interleukins, Signaling by Ligand-Responsive EGFR Variants in Cancer, Signaling by MET, Signaling by NOTCH, Signaling by NOTCH1, Signaling by NOTCH1 HD Domain Mutants in Cancer, Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, Signaling by NOTCH1 PEST Domain Mutants in Cancer, Signaling by NOTCH1 in Cancer, Signaling by NOTCH2, Signaling by NOTCH3, Signaling by NOTCH4, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by ROBO receptors, Signaling by Receptor Tyrosine Kinases, Signaling by TGF-beta Receptor Complex, Signaling by TGFB family members, Signaling by WNT, Signaling by the B Cell Receptor (BCR), Spry regulation of FGF signaling, Stabilization of p53, Stimuli-sensing channels, Suppression of phagosomal maturation, Switching of origins to a post-replicative state, Synthesis And Processing Of GAG, GAGPOL Polyproteins, Synthesis of DNA, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, TAK1-dependent IKK and NF-kappa-B activation , TCF dependent signaling in response to WNT, TCR signaling, TGF-beta receptor signaling activates SMADs, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition), TICAM1, RIP1-mediated IKK complex recruitment, TICAM1,TRAF6-dependent induction of TAK1 complex, TICAM1-dependent activation of IRF3/IRF7, TNF signaling, TNFR1-induced NF-kappa-B signaling pathway, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRAF6-mediated induction of TAK1 complex within TLR4 complex, TRIF (TICAM1)-mediated TLR4 signaling , Termination of translesion DNA synthesis, The role of GTSE1 in G2/M progression after G2 checkpoint, Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, Transcriptional regulation by RUNX1, Transcriptional regulation by RUNX2, Transcriptional regulation by RUNX3, Translation, Translation of Structural Proteins, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, Transport of small molecules, UCH proteinases, Ub-specific processing proteases, Ubiquitin mediated proteolysis - Homo sapiens (human), Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A, Ubiquitin-dependent degradation of Cyclin D, VLDLR internalisation and degradation, Vesicle-mediated transport, Vif-mediated degradation of APOBEC3G, Viral Infection Pathways, Viral mRNA Translation, Vpu mediated degradation of CD4, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, activated TAK1 mediates p38 MAPK activation, p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint, p53-Independent G1/S DNA Damage Checkpoint, p75 NTR receptor-mediated signalling, p75NTR recruits signalling complexes, p75NTR signals via NF-kB, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62987
Entrez ID: 7311
|
Does Knockout of DDX6 in Cancer Cell Line causally result in cell proliferation?
| 1
| 948
|
Knockout
|
DDX6
|
cell proliferation
|
Cancer Cell Line
|
Gene: DDX6 (DEAD-box helicase 6)
Type: protein-coding
Summary: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012].
Gene Ontology: BP: P-body assembly, miRNA-mediated gene silencing by inhibition of translation, negative regulation of neuron differentiation, negative regulation of translation, neuron differentiation, spermatid differentiation, spermatogenesis, stem cell population maintenance, stress granule assembly, viral RNA genome packaging; MF: ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, cadherin binding, helicase activity, hydrolase activity, mRNA binding, nucleic acid binding, nucleotide binding, protein binding, protein domain specific binding; CC: P-body, RISC complex, adherens junction, chromatoid body, concave side of sperm head, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, cytosol, heterochromatin, membrane, nucleus, outer dense fiber, perinuclear region of cytoplasm, plasma membrane, sperm annulus
Pathways: Deadenylation-dependent mRNA decay, EGFR1, Metabolism of RNA, RNA degradation - Homo sapiens (human), mRNA decay by 5' to 3' exoribonuclease
UniProt: P26196
Entrez ID: 1656
|
Does Knockout of STX18 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 1
| 763
|
Knockout
|
STX18
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: STX18 (syntaxin 18)
Type: protein-coding
Summary: This gene encodes a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) which is part of a membrane tethering complex that includes other SNAREs and several peripheral membrane proteins, and is involved in vesicular transport between the endoplasmic reticulum (ER) and the Golgi complex. The encoded protein is important for the organization of the smooth, rough, and exit site ER subdomains. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016].
Gene Ontology: BP: endoplasmic reticulum membrane organization, intracellular protein transport, membrane fusion, positive regulation of ER to Golgi vesicle-mediated transport, positive regulation of organelle assembly, protein transport, regulation of Golgi organization, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: SNAP receptor activity, protein binding, protein domain specific binding; CC: Golgi apparatus, Golgi membrane, SNARE complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Phagosome - Homo sapiens (human), SNARE interactions in vesicular transport - Homo sapiens (human), Vesicle-mediated transport
UniProt: Q9P2W9
Entrez ID: 53407
|
Does Knockout of ATG10 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 865
|
Knockout
|
ATG10
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: ATG10 (autophagy related 10)
Type: protein-coding
Summary: Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: ER overload response, autophagosome assembly, autophagy, mitophagy, protein modification by small protein conjugation, protein transport; MF: Atg12 conjugating enzyme activity, Atg12 transferase activity, protein binding, transferase activity, ubiquitin-like protein transferase activity; CC: cytoplasm, cytosol
Pathways: Autophagy, Autophagy - animal - Homo sapiens (human), Autophagy - other - Homo sapiens (human), Macroautophagy, Nanoparticle triggered autophagic cell death, Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway, Senescence and Autophagy in Cancer
UniProt: Q9H0Y0
Entrez ID: 83734
|
Does Knockout of CDKN2A-AS1 in Colorectal Cancer Cell Line causally result in response to chemicals?
| 0
| 1,414
|
Knockout
|
CDKN2A-AS1
|
response to chemicals
|
Colorectal Cancer Cell Line
|
Gene: CDKN2A-AS1 (CDKN2A antisense RNA 1)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of SLC6A14 in Ewing's Sarcoma Cell Line causally result in cell proliferation?
| 0
| 763
|
Knockout
|
SLC6A14
|
cell proliferation
|
Ewing's Sarcoma Cell Line
|
Gene: SLC6A14 (solute carrier family 6 member 14)
Type: protein-coding
Summary: This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010].
Gene Ontology: BP: (R)-carnitine transmembrane transport, alanine transport, amino acid import across plasma membrane, amino acid transmembrane transport, amino acid transport, aromatic amino acid transport, beta-alanine transport, branched-chain amino acid transport, chloride transport, glycine import across plasma membrane, response to toxic substance, sodium ion transmembrane transport; MF: (R)-carnitine transmembrane transporter activity, alanine transmembrane transporter activity, amino acid transmembrane transporter activity, aromatic amino acid transmembrane transporter activity, beta-alanine transmembrane transporter activity, branched-chain amino acid:sodium symporter activity, neutral, basic amino acid:sodium:chloride symporter activity, symporter activity, transmembrane transporter activity; CC: apical plasma membrane, extracellular exosome, membrane, plasma membrane, vesicle
Pathways: Amino acid transport across the plasma membrane, Disease, Disorders of transmembrane transporters, NRF2 pathway, Nuclear Receptors Meta-Pathway, SLC transporter disorders, SLC-mediated transmembrane transport, SLC-mediated transport of amino acids, SLC-mediated transport of neurotransmitters, Transport of small molecules, Variant SLC6A14 may confer susceptibility towards obesity
UniProt: Q9UN76
Entrez ID: 11254
|
Does Knockout of FAM30A in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,340
|
Knockout
|
FAM30A
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: FAM30A (family with sequence similarity 30 member A)
Type: ncRNA
Summary: family with sequence similarity 30 member A
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 9834
|
Does Knockout of PWP1 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
PWP1
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: PWP1 (PWP1 homolog, endonuclein)
Type: protein-coding
Summary: The protein encoded by this gene contains several WD-40 repeats and is found mostly in the nucleus. The expression and localization of this protein are cell cycle dependent. Expression of this gene is upregulated in pancreatic adenocarcinoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].
Gene Ontology: BP: DNA-templated transcription, chromatin organization, negative regulation of DNA-templated transcription, positive regulation of stem cell differentiation, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, rRNA processing, regulation of DNA-templated transcription, ribosome biogenesis; MF: histone H4K20me3 reader activity, histone chaperone activity; CC: Golgi apparatus, chromosome, nucleolus, nucleus
Pathways:
UniProt: Q13610
Entrez ID: 11137
|
Does Knockout of DSG1 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 287
|
Knockout
|
DSG1
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: DSG1 (desmoglein 1)
Type: protein-coding
Summary: This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015].
Gene Ontology: BP: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, cell-cell adhesion, cell-cell junction assembly, homophilic cell adhesion via plasma membrane adhesion molecules, maternal process involved in female pregnancy, protein stabilization, response to progesterone; MF: calcium ion binding, gamma-catenin binding, metal ion binding, protein binding, toxic substance binding; CC: anchoring junction, apical plasma membrane, cell-cell junction, cornified envelope, cytoplasm, cytoplasmic side of plasma membrane, cytosol, desmosome, ficolin-1-rich granule membrane, lateral plasma membrane, membrane, nucleus, plasma membrane
Pathways: Staphylococcus aureus infection - Homo sapiens (human)
UniProt: Q02413
Entrez ID: 1828
|
Does Knockout of FUZ in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
FUZ
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: FUZ (fuzzy planar cell polarity protein)
Type: protein-coding
Summary: This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012].
Gene Ontology: BP: cell projection organization, cilium assembly, embryonic body morphogenesis, embryonic skeletal system morphogenesis, establishment of planar polarity, hair follicle development, intraciliary transport, negative regulation of canonical Wnt signaling pathway, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation, negative regulation of neural crest formation, neural tube closure, neural tube development, non-motile cilium assembly, positive regulation of cilium assembly, protein transport, regulation of cilium assembly, regulation of smoothened signaling pathway, vesicle-mediated transport; MF: phosphatidylinositol binding, protein binding; CC: cell projection, cilium, cytoplasm, cytoskeleton, extracellular exosome
Pathways: Ciliary landscape, Genes related to primary cilium development (based on CRISPR), Hedgehog 'off' state, Signal Transduction, Signaling by Hedgehog
UniProt: Q9BT04
Entrez ID: 80199
|
Does Knockout of KDM2A in Bladder Carcinoma causally result in cell proliferation?
| 1
| 489
|
Knockout
|
KDM2A
|
cell proliferation
|
Bladder Carcinoma
|
Gene: KDM2A (lysine demethylase 2A)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Gene Ontology: BP: chromatin organization, chromatin remodeling, circadian regulation of gene expression, double-strand break repair via nonhomologous end joining, negative regulation of transcription by competitive promoter binding, regulation of circadian rhythm, regulation of transcription by RNA polymerase II, rhythmic process; MF: DNA binding, dioxygenase activity, histone H3K36 demethylase activity, histone H3K36me/H3K36me2 demethylase activity, histone demethylase activity, metal ion binding, oxidoreductase activity, protein binding, transcription coregulator activity, unmethylated CpG binding, zinc ion binding; CC: chromosome, nucleoplasm, nucleus
Pathways: Chromatin modifying enzymes, Chromatin organization, HDMs demethylate histones, The oncogenic action of 2-hydroxyglutarate, The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria , The oncogenic action of Fumarate, The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria, The oncogenic action of Succinate
UniProt: Q9Y2K7
Entrez ID: 22992
|
Does Knockout of ACP6 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
ACP6
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: ACP6 (acid phosphatase 6, lysophosphatidic)
Type: protein-coding
Summary: This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016].
Gene Ontology: BP: hematopoietic progenitor cell differentiation, lipid metabolic process, lysobisphosphatidic acid metabolic process, phosphatidic acid biosynthetic process, phospholipid metabolic process; MF: acid phosphatase activity, hydrolase activity, lysophosphatidic acid phosphatase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: 1q21.1 copy number variation syndrome, Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism, Synthesis of PA
UniProt: Q9NPH0
Entrez ID: 51205
|
Does Knockout of TTLL4 in Chronic Myelogenous Leukemia Cell Line causally result in response to chemicals?
| 0
| 2,383
|
Knockout
|
TTLL4
|
response to chemicals
|
Chronic Myelogenous Leukemia Cell Line
|
Gene: TTLL4 (tubulin tyrosine ligase like 4)
Type: protein-coding
Summary: Predicted to enable tubulin binding activity and tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization and protein polyglutamylation. Predicted to act upstream of or within regulation of blastocyst development. Predicted to be located in cytosol. Predicted to be active in cilium. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: microtubule cytoskeleton organization, peptidyl-glutamic acid modification, protein polyglutamylation, regulation of blastocyst development; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, protein-glutamic acid ligase activity, protein-glutamic acid ligase activity, initiating, tubulin binding, tubulin-glutamic acid ligase activity; CC: 9+0 non-motile cilium, cell projection, ciliary basal body, cilium, cytoplasm, cytoskeleton, cytosol, microtubule
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: Q14679
Entrez ID: 9654
|
Does Knockout of NUF2 in Medulloblastoma Cell Line causally result in cell proliferation?
| 1
| 1,813
|
Knockout
|
NUF2
|
cell proliferation
|
Medulloblastoma Cell Line
|
Gene: NUF2 (NUF2 component of NDC80 kinetochore complex)
Type: protein-coding
Summary: This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: attachment of mitotic spindle microtubules to kinetochore, attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, kinetochore organization, meiotic chromosome segregation, mitotic spindle assembly checkpoint signaling, mitotic spindle organization; MF: microtubule binding, protein binding, protein-containing complex binding; CC: Ndc80 complex, chromosome, chromosome, centromeric region, cytosol, kinetochore, membrane, nucleoplasm, nucleus, outer kinetochore
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPases Activate Formins, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q9BZD4
Entrez ID: 83540
|
Does Knockout of PHF24 in Huh-7 Cell causally result in response to virus?
| 0
| 1,382
|
Knockout
|
PHF24
|
response to virus
|
Huh-7 Cell
|
Gene: PHF24 (PHD finger protein 24)
Type: protein-coding
Summary: Predicted to enable metal ion binding activity. Predicted to act upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of pain; gamma-aminobutyric acid signaling pathway; and regulation of GABAergic synaptic transmission. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: detection of mechanical stimulus involved in sensory perception of pain, gamma-aminobutyric acid signaling pathway, negative regulation of DNA-templated transcription, regulation of G protein-coupled receptor signaling pathway, regulation of synaptic transmission, GABAergic; MF: metal ion binding, protein binding, transcription corepressor activity, zinc ion binding; CC: cytoplasm, glutamatergic synapse, nucleus, synaptic vesicle membrane
Pathways:
UniProt: Q9UPV7
Entrez ID: 23349
|
Does Knockout of FGFR1OP2 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 839
|
Knockout
|
FGFR1OP2
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: FGFR1OP2 (FGFR1 oncogene partner 2)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in response to wounding. Predicted to act upstream of or within wound healing. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: response to wounding, wound healing; MF: identical protein binding, protein binding; CC: cytoplasm, cytosol
Pathways: Disease, Diseases of signal transduction by growth factor receptors and second messengers, FGFR1 mutant receptor activation, Signaling by FGFR in disease, Signaling by FGFR1 in disease, Signaling by cytosolic FGFR1 fusion mutants
UniProt: Q9NVK5
Entrez ID: 26127
|
Does Knockout of UBE2Z in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 287
|
Knockout
|
UBE2Z
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: UBE2Z (ubiquitin conjugating enzyme E2 Z)
Type: protein-coding
Summary: This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012].
Gene Ontology: BP: apoptotic process, negative regulation of apoptotic process, positive regulation of apoptotic process, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, molecular adaptor activity, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Post-translational protein modification, Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9H832
Entrez ID: 65264
|
Does Knockout of HEPN1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 951
|
Knockout
|
HEPN1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: HEPN1 (hepatocellular carcinoma, down-regulated 1)
Type: protein-coding
Summary: This gene is expressed predominantly in the liver. Transient transfection studies show the expression of this gene significantly inhibits cell growth, suggesting a role for this gene in apoptosis. Expression of this gene is down-regulated or lost in hepatocellular carcinomas (HCC), suggesting that loss of this gene is involved in carcinogenesis of hepatocytes (PMID:12971969). This gene maps to the 3'-noncoding region of the HEPACAM gene (GeneID:220296) on the antisense strand. [provided by RefSeq, Aug 2020].
Gene Ontology:
Pathways:
UniProt: Q6WQI6
Entrez ID: 641654
|
Does Knockout of DAOA in Astrocytoma Cell Line causally result in cell proliferation?
| 0
| 904
|
Knockout
|
DAOA
|
cell proliferation
|
Astrocytoma Cell Line
|
Gene: DAOA (D-amino acid oxidase activator)
Type: protein-coding
Summary: This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011].
Gene Ontology: BP: D-amino acid metabolic process, positive regulation of protein catabolic process; CC: Golgi apparatus, cytoplasm, cytosol, mitochondrion, perinuclear region of cytoplasm
Pathways:
UniProt: P59103
Entrez ID: 267012
|
Does Knockout of THOC5 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 815
|
Knockout
|
THOC5
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: THOC5 (THO complex subunit 5)
Type: protein-coding
Summary: Predicted to enable mRNA binding activity. Involved in several processes, including monocyte differentiation; negative regulation of DNA damage checkpoint; and viral mRNA export from host cell nucleus. Located in nucleoplasm. Part of THO complex part of transcription export complex. Colocalizes with chromosome, telomeric region. Implicated in breast carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: RNA splicing, cell differentiation, mRNA export from nucleus, mRNA processing, mRNA transport, monocyte differentiation, primitive hemopoiesis; MF: RNA binding, mRNA binding, protein binding; CC: THO complex, THO complex part of transcription export complex, chromosome, telomeric region, cytoplasm, nucleoplasm, nucleus, transcription export complex
Pathways: Cytokine Signaling in Immune system, Gene expression (Transcription), Immune System, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, RNA transport - Homo sapiens (human), Signaling by CSF1 (M-CSF) in myeloid cells, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA 3'-end processing
UniProt: Q13769
Entrez ID: 8563
|
Does Knockout of GJA9 in Multiple Myeloma Cell Line causally result in cell proliferation?
| 0
| 816
|
Knockout
|
GJA9
|
cell proliferation
|
Multiple Myeloma Cell Line
|
Gene: GJA9 (gap junction protein alpha 9)
Type: protein-coding
Summary: Connexins, such as GJA9, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008].
Gene Ontology: BP: cell communication, cell-cell signaling, transmembrane transport; CC: anchoring junction, connexin complex, gap junction, membrane, plasma membrane
Pathways: Calcium Regulation in the Cardiac Cell, Gap junction assembly, Gap junction trafficking, Gap junction trafficking and regulation, Membrane Trafficking, Vesicle-mediated transport
UniProt: P57773
Entrez ID: 81025
|
Does Knockout of ZFP37 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,339
|
Knockout
|
ZFP37
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ZFP37 (ZFP37 zinc finger protein)
Type: protein-coding
Summary: This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9Y6Q3
Entrez ID: 7539
|
Does Knockout of CYB5R4 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 1
| 758
|
Knockout
|
CYB5R4
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: CYB5R4 (cytochrome b5 reductase 4)
Type: protein-coding
Summary: NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5A; MIM 613218) and CYB5 reductase (CYB5R3; MIM 613213) (Zhu et al., 1999 [PubMed 10611283]).[supplied by OMIM, Jan 2010].
Gene Ontology: BP: bicarbonate transport, cell development, detection of oxygen, glucose homeostasis, insulin secretion, reactive oxygen species metabolic process, response to antibiotic, superoxide metabolic process; MF: NAD(P)H oxidase H2O2-forming activity, cytochrome-b5 reductase activity, acting on NAD(P)H, heme binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, perinuclear region of cytoplasm
Pathways: Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Erythrocytes take up carbon dioxide and release oxygen, O2/CO2 exchange in erythrocytes, Oxidation by Cytochrome P450, Transport of small molecules
UniProt: Q7L1T6
Entrez ID: 51167
|
Does Knockout of WDR24 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 305
|
Knockout
|
WDR24
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: WDR24 (WD repeat domain 24)
Type: protein-coding
Summary: Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and regulation of autophagy. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: TORC1 signaling, autophagy, cellular response to amino acid starvation, cellular response to nutrient levels, cytoplasmic translation, negative regulation of TORC1 signaling, negative regulation of translational initiation, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of macroautophagy, positive regulation of translational initiation, protein K6-linked ubiquitination, protein localization to lysosome, protein ubiquitination, regulation of autophagy; MF: metal ion binding, protein binding, transferase activity, ubiquitin protein ligase activity, zinc ion binding; CC: GATOR2 complex, cytosol, lysosomal membrane, lysosome, membrane, vacuolar membrane
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, mTOR signaling pathway - Homo sapiens (human)
UniProt: Q96S15
Entrez ID: 84219
|
Does Knockout of ABRAXAS2 in Endometrial Cancer Cell Line causally result in cell proliferation?
| 0
| 758
|
Knockout
|
ABRAXAS2
|
cell proliferation
|
Endometrial Cancer Cell Line
|
Gene: ABRAXAS2 (abraxas 2, BRISC complex subunit)
Type: protein-coding
Summary: Enables microtubule binding activity and polyubiquitin modification-dependent protein binding activity. Involved in several processes, including mitotic spindle assembly; protein K63-linked deubiquitination; and response to ischemia. Located in cytoplasm. Part of BRISC complex. Colocalizes with microtubule minus-end; midbody; and spindle pole centrosome. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: attachment of spindle microtubules to kinetochore, cell division, chromosome segregation, mitotic cell cycle, mitotic spindle assembly, protein K63-linked deubiquitination, response to ischemia; MF: microtubule binding, polyubiquitin modification-dependent protein binding, protein binding; CC: BRISC complex, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, microtubule, microtubule minus-end, midbody, nucleus, spindle pole, spindle pole centrosome
Pathways: Deubiquitination, Metabolism of proteins, Metalloprotease DUBs, Post-translational protein modification
UniProt: Q15018
Entrez ID: 23172
|
Does Knockout of NANOS1 in Chronic Myeloid Leukemia Cell Line causally result in response to chemicals?
| 1
| 1,397
|
Knockout
|
NANOS1
|
response to chemicals
|
Chronic Myeloid Leukemia Cell Line
|
Gene: NANOS1 (nanos C2HC-type zinc finger 1)
Type: protein-coding
Summary: This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: cell migration, cerebellar neuron development, epithelial cell migration, mRNA destabilization, negative regulation of translation, oogenesis, post-transcriptional regulation of gene expression, regulation of cell growth, regulation of translation, tissue homeostasis; MF: RNA binding, enzyme activator activity, mRNA binding, metal ion binding, protein binding, translation repressor activity, zinc ion binding; CC: cytoplasm, perinuclear region of cytoplasm
Pathways: Male infertility
UniProt: Q8WY41
Entrez ID: 340719
|
Does Activation of TRIR in T cell causally result in protein/peptide accumulation?
| 0
| 2,425
|
Activation
|
TRIR
|
protein/peptide accumulation
|
T cell
|
Gene: TRIR (telomerase RNA component interacting RNase)
Type: protein-coding
Summary: Enables 3'-5' exonuclease activity and 5'-3' exonuclease activity. Involved in RNA phosphodiester bond hydrolysis, exonucleolytic and rRNA catabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: MF: 3'-5' exonuclease activity, 5'-3' exonuclease activity, RNA binding, exonuclease activity, hydrolase activity, nuclease activity, protein binding
Pathways:
UniProt: Q9BQ61
Entrez ID: 79002
|
Does Knockout of CPSF6 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 527
|
Knockout
|
CPSF6
|
cell proliferation
|
Melanoma Cell Line
|
Gene: CPSF6 (cleavage and polyadenylation specific factor 6)
Type: protein-coding
Summary: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, mRNA 3'-end processing, mRNA alternative polyadenylation, mRNA processing, positive regulation of RNA export from nucleus, protein heterotetramerization, protein tetramerization; MF: RNA binding, exon-exon junction complex binding, mRNA binding, nucleic acid binding, protein binding, ribosomal large subunit binding; CC: cytoplasm, interchromatin granule, mRNA cleavage and polyadenylation specificity factor complex, mRNA cleavage factor complex, membrane, nuclear speck, nucleoplasm, nucleus, paraspeckles, perichromatin fibrils, ribonucleoprotein complex
Pathways: mRNA surveillance pathway - Homo sapiens (human)
UniProt: Q16630
Entrez ID: 11052
|
Does Knockout of ANAPC10 in Oral Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 1,311
|
Knockout
|
ANAPC10
|
cell proliferation
|
Oral Squamous Cell Carcinoma Cell Line
|
Gene: ANAPC10 (anaphase promoting complex subunit 10)
Type: protein-coding
Summary: ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of meiotic cell cycle, regulation of mitotic cell cycle; CC: anaphase-promoting complex, cytoplasm, cytosol, nucleoplasm
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Aberrant regulation of mitotic cell cycle due to RB1 defects, Aberrant regulation of mitotic exit in cancer due to RB1 defects, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle, Cell cycle - Homo sapiens (human), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Disease, Diseases of mitotic cell cycle, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Homo sapiens (human), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Homo sapiens (human), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Homo sapiens (human), RNA Polymerase II Transcription, Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, TGF_beta_Receptor, Transcriptional Regulation by VENTX, Ubiquitin mediated proteolysis - Homo sapiens (human)
UniProt: Q9UM13
Entrez ID: 10393
|
Does Knockout of STK35 in Breast Cancer Cell Line causally result in cell proliferation?
| 0
| 235
|
Knockout
|
STK35
|
cell proliferation
|
Breast Cancer Cell Line
|
Gene: STK35 (serine/threonine kinase 35)
Type: protein-coding
Summary: The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: negative regulation of G2/M transition of mitotic cell cycle, negative regulation of G2/MI transition of meiotic cell cycle; MF: ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nuclear body, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8TDR2
Entrez ID: 140901
|
Does Knockout of DHX15 in Lung Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 1
| 839
|
Knockout
|
DHX15
|
cell proliferation
|
Lung Squamous Cell Carcinoma Cell Line
|
Gene: DHX15 (DEAH-box helicase 15)
Type: protein-coding
Summary: The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: RNA splicing, antiviral innate immune response, defense response to bacterium, defense response to virus, immune system process, innate immune response, mRNA processing, mRNA splicing, via spliceosome, positive regulation of canonical NF-kappaB signal transduction, response to alkaloid, response to toxic substance; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on RNA, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, nucleic acid binding, nucleotide binding, protein binding; CC: U12-type spliceosomal complex, U2-type post-mRNA release spliceosomal complex, nuclear speck, nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Spliceosome - Homo sapiens (human), mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: O43143
Entrez ID: 1665
|
Does Knockout of ADAMTS2 in Cancer Cell Line causally result in cell proliferation?
| 0
| 948
|
Knockout
|
ADAMTS2
|
cell proliferation
|
Cancer Cell Line
|
Gene: ADAMTS2 (ADAM metallopeptidase with thrombospondin type 1 motif 2)
Type: protein-coding
Summary: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: collagen catabolic process, collagen fibril organization, extracellular matrix organization, lung development, protein processing, proteolysis, skin development, spermatogenesis; MF: hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: extracellular matrix, extracellular region
Pathways: Collagen biosynthesis and modifying enzymes, Collagen formation, Defective B3GALTL causes PpS, Disease, Diseases associated with O-glycosylation of proteins, Diseases of glycosylation, Diseases of metabolism, Extracellular matrix organization, Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, Post-translational protein modification, Type I collagen synthesis in the context of Osteogenesis imperfecta
UniProt: O95450
Entrez ID: 9509
|
Does Knockout of RHOQ in Colorectal Cancer Cell Line causally result in cell proliferation?
| 1
| 783
|
Knockout
|
RHOQ
|
cell proliferation
|
Colorectal Cancer Cell Line
|
Gene: RHOQ (ras homolog family member Q)
Type: protein-coding
Summary: This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011].
Gene Ontology: BP: GTP metabolic process, actin cytoskeleton organization, actin filament organization, cellular response to insulin stimulus, cortical actin cytoskeleton organization, endocytosis, establishment of cell polarity, insulin receptor signaling pathway, negative regulation of protein localization to plasma membrane, positive regulation of D-glucose import, positive regulation of filopodium assembly, positive regulation of transcription by RNA polymerase II, regulation of actin cytoskeleton organization, regulation of cell shape, signal transduction, small GTPase-mediated signal transduction; MF: GBD domain binding, GTP binding, GTPase activity, nucleotide binding, profilin binding, protein binding, protein kinase binding; CC: Golgi-associated vesicle membrane, actin filament, cytoplasm, extracellular exosome, membrane, membrane raft, plasma membrane
Pathways: Angiopoietin Like Protein 8 Regulatory Pathway, Insulin Pathway, Insulin Signaling, Insulin signaling pathway - Homo sapiens (human), Insulin-mediated glucose transport, Membrane Trafficking, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases regulate CFTR trafficking, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Translocation of SLC2A4 (GLUT4) to the plasma membrane, Vesicle-mediated transport
UniProt: P17081
Entrez ID: 23433
|
Does Knockout of FBXW11 in Primary Effusion Lymphoma Cell Line causally result in cell proliferation?
| 1
| 2,114
|
Knockout
|
FBXW11
|
cell proliferation
|
Primary Effusion Lymphoma Cell Line
|
Gene: FBXW11 (F-box and WD repeat domain containing 11)
Type: protein-coding
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, Wnt signaling pathway, brain morphogenesis, establishment of mitotic spindle orientation, germ cell development, microtubule organizing center organization, negative regulation of canonical NF-kappaB signal transduction, nuclear migration, positive regulation of DNA-templated transcription, positive regulation of canonical NF-kappaB signal transduction, positive regulation of circadian rhythm, positive regulation of proteolysis, proteasome-mediated ubiquitin-dependent protein catabolic process, protein dephosphorylation, protein destabilization, protein polyubiquitination, protein ubiquitination, retrograde axonal transport, rhythmic process, vesicle transport along microtubule; MF: dynein complex binding, microtubule plus-end binding, protein binding, protein dimerization activity, ubiquitin-like ligase-substrate adaptor activity; CC: SCF ubiquitin ligase complex, axon cytoplasm, centrosome, cytoplasm, cytoplasmic microtubule, cytosol, kinetochore, microtubule associated complex, neuron projection, neuronal cell body, nuclear envelope, nucleus, ubiquitin ligase complex
Pathways: Cellular senescence - Homo sapiens (human), Circadian rhythm - Homo sapiens (human), Hedgehog signaling events mediated by Gli proteins, Hedgehog signaling pathway - Homo sapiens (human), Hippo signaling pathway - Homo sapiens (human), Human immunodeficiency virus 1 infection - Homo sapiens (human), Oocyte meiosis - Homo sapiens (human), Presenilin action in Notch and Wnt signaling, Prolactin, Shigellosis - Homo sapiens (human), Signaling events mediated by VEGFR1 and VEGFR2, TNF-alpha signaling pathway, TNFalpha, Ubiquitin mediated proteolysis - Homo sapiens (human), VEGFA-VEGFR2 Signaling Pathway, Wnt signaling pathway - Homo sapiens (human)
UniProt: Q9UKB1
Entrez ID: 23291
|
Does Knockout of ABT1 in Non-Small Cell Lung Cancer Cell Line causally result in cell proliferation?
| 1
| 1,246
|
Knockout
|
ABT1
|
cell proliferation
|
Non-Small Cell Lung Cancer Cell Line
|
Gene: ABT1 (activator of basal transcription 1)
Type: protein-coding
Summary: Basal transcription of genes by RNA polymerase II requires the interaction of TATA-binding protein (TBP) with the core region of class II promoters. Studies in mouse suggest that the protein encoded by this gene likely activates basal transcription from class II promoters by interaction with TBP and the class II promoter DNA. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), positive regulation of DNA-templated transcription, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, small-subunit processome assembly, spinal cord motor neuron differentiation, transcription by RNA polymerase II; MF: DNA binding, RNA binding, nucleic acid binding, protein binding, transcription coactivator activity; CC: nucleolus, nucleus, transcription regulator complex
Pathways:
UniProt: Q9ULW3
Entrez ID: 29777
|
Does Knockout of ZNF112 in Retinal Pigment Epithelium Cell Line causally result in response to chemicals?
| 0
| 1,329
|
Knockout
|
ZNF112
|
response to chemicals
|
Retinal Pigment Epithelium Cell Line
|
Gene: ZNF112 (zinc finger protein 112)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Homo sapiens (human), RNA Polymerase II Transcription
UniProt: Q9UJU3
Entrez ID: 7771
|
Does Knockout of FAM161B in Lymphoma or Leukaemia Cell Line causally result in protein/peptide accumulation?
| 0
| 1,218
|
Knockout
|
FAM161B
|
protein/peptide accumulation
|
Lymphoma or Leukaemia Cell Line
|
Gene: FAM161B (FAM161 centrosomal protein B)
Type: protein-coding
Summary: Predicted to be involved in cilium organization. Located in cytoplasmic microtubule. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: CC: cytoplasmic microtubule, cytoskeleton, microtubule cytoskeleton
Pathways:
UniProt: Q96MY7
Entrez ID: 145483
|
Does Knockout of ZNF71 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,459
|
Knockout
|
ZNF71
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: ZNF71 (zinc finger protein 71)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: Q9NQZ8
Entrez ID: 58491
|
Does Knockout of PGM1 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,789
|
Knockout
|
PGM1
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: PGM1 (phosphoglucomutase 1)
Type: protein-coding
Summary: The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010].
Gene Ontology: BP: carbohydrate metabolic process, galactose catabolic process via UDP-galactose, Leloir pathway, gluconeogenesis, glucose metabolic process, glycolytic process; MF: intramolecular phosphotransferase activity, isomerase activity, magnesium ion binding, metal ion binding, phosphoglucomutase activity, protein binding; CC: cytoplasm, cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, tertiary granule lumen
Pathways: Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), D-galactose degradation V (Leloir pathway), Defective PGM1 causes PGM1-CDG, Disease, Diseases associated with glycosylation precursor biosynthesis, Diseases of glycosylation, Diseases of metabolism, Ectoderm Differentiation, Fructose-1,6-diphosphatase deficiency, GDP-glucose biosynthesis II, Galactose Metabolism, Galactose catabolism, Galactose metabolism - Homo sapiens (human), Galactosemia, Galactosemia II (GALK), Galactosemia III, Gluconeogenesis, Glucose-6-phosphate dehydrogenase deficiency, Glucuronidation, Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease, Glycogen Synthesis and Degradation, Glycogen breakdown (glycogenolysis), Glycogen metabolism, Glycogen synthesis, Glycogen synthetase deficiency, Glycogenosis, Type IA. Von gierke disease, Glycogenosis, Type IB, Glycogenosis, Type IC, Glycogenosis, Type III. Cori disease, Debrancher glycogenosis, Glycogenosis, Type IV. Amylopectinosis, Anderson disease, Glycogenosis, Type VI. Hers disease, Glycolysis / Gluconeogenesis - Homo sapiens (human), HIF-1-alpha transcription factor network, Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Mucopolysaccharidosis VI. Sly syndrome, Neutrophil degranulation, Nucleotide Sugars Metabolism, Pathways in clear cell renal cell carcinoma, Pentose Phosphate Pathway, Pentose phosphate pathway - Homo sapiens (human), Phosphoenolpyruvate carboxykinase deficiency 1 (PEPCK1), Purine metabolism - Homo sapiens (human), Ribose-5-phosphate isomerase deficiency, Starch and Sucrose Metabolism, Starch and sucrose metabolism - Homo sapiens (human), Sucrase-isomaltase deficiency, TCR, Transaldolase deficiency, Triosephosphate isomerase, glycogen biosynthesis, glycogenolysis
UniProt: P36871
Entrez ID: 5236
|
Does Knockout of GTPBP4 in Chronic Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 149
|
Knockout
|
GTPBP4
|
cell proliferation
|
Chronic Myeloid Leukemia Cell Line
|
Gene: GTPBP4 (GTP binding protein 4)
Type: protein-coding
Summary: GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), negative regulation of DNA replication, negative regulation of G2/M transition of mitotic cell cycle, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of cell-cell adhesion, negative regulation of protein ubiquitination, osteoblast differentiation, protein stabilization, ribosomal large subunit biogenesis, ribosome biogenesis; MF: GTP binding, GTPase activity, RNA binding, nucleotide binding, preribosome binding, protein binding; CC: cytoplasm, cytosol, membrane, nuclear membrane, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Ribosome biogenesis in eukaryotes - Homo sapiens (human)
UniProt: Q9BZE4
Entrez ID: 23560
|
Does Knockout of PMM2 in Cervical Adenocarcinoma Cell Line causally result in response to virus?
| 0
| 2,430
|
Knockout
|
PMM2
|
response to virus
|
Cervical Adenocarcinoma Cell Line
|
Gene: PMM2 (phosphomannomutase 2)
Type: protein-coding
Summary: The protein encoded by this gene catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate, which is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in this gene have been shown to cause defects in glycoprotein biosynthesis, which manifests as carbohydrate-deficient glycoprotein syndrome type I. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: GDP-D-mannose biosynthetic process from fructose-6-phosphate, GDP-mannose biosynthetic process, GDP-mannose biosynthetic process from mannose, mannose metabolic process, protein N-linked glycosylation, protein glycosylation; MF: isomerase activity, metal ion binding, phosphomannomutase activity, protein binding; CC: cilium, cytoplasm, cytosol, microtubule cytoskeleton, neuronal cell body, nucleoplasm
Pathways: Amino sugar and nucleotide sugar metabolism - Homo sapiens (human), Asparagine N-linked glycosylation, Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, Defective PMM2 causes PMM2-CDG, Disease, Diseases associated with glycosylation precursor biosynthesis, Diseases of glycosylation, Diseases of metabolism, Fructose and mannose metabolism - Homo sapiens (human), GDP-mannose biosynthesis, Metabolism of proteins, Nephrotic syndrome, Post-translational protein modification, Synthesis of GDP-mannose, Synthesis of substrates in N-glycan biosythesis
UniProt: O15305
Entrez ID: 5373
|
Does Knockout of C19orf53 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 865
|
Knockout
|
C19orf53
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: C19orf53 (chromosome 19 open reading frame 53)
Type: protein-coding
Summary: chromosome 19 open reading frame 53
Gene Ontology:
Pathways:
UniProt: Q9UNZ5
Entrez ID: 28974
|
Does Knockout of FAT2 in Pre-B Acute Lymphoblastic Leukemia Cell Line causally result in cell proliferation?
| 0
| 1,576
|
Knockout
|
FAT2
|
cell proliferation
|
Pre-B Acute Lymphoblastic Leukemia Cell Line
|
Gene: FAT2 (FAT atypical cadherin 2)
Type: protein-coding
Summary: This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cell adhesion, cell-cell adhesion, cell-cell adhesion mediated by cadherin, cell-substrate adhesion, epithelial cell migration, homophilic cell adhesion via plasma membrane adhesion molecules; CC: Golgi apparatus, adherens junction, anchoring junction, cell-cell junction, extracellular exosome, membrane, plasma membrane
Pathways:
UniProt: Q9NYQ8
Entrez ID: 2196
|
Does Knockout of LSM3 in Ovarian Cancer Cell Line causally result in cell proliferation?
| 1
| 699
|
Knockout
|
LSM3
|
cell proliferation
|
Ovarian Cancer Cell Line
|
Gene: LSM3 (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
Type: protein-coding
Summary: Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004].
Gene Ontology: BP: P-body assembly, RNA splicing, mRNA processing, mRNA splicing, via spliceosome; MF: RNA binding, U6 snRNA 3'-end binding, protein binding; CC: Lsm1-7-Pat1 complex, Lsm2-8 complex, P-body, U2-type precatalytic spliceosome, U4/U6 x U5 tri-snRNP complex, U6 snRNP, catalytic step 2 spliceosome, cytosol, nucleoplasm, nucleus, precatalytic spliceosome, ribonucleoprotein complex, spliceosomal complex
Pathways: Deadenylation-dependent mRNA decay, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, RNA degradation - Homo sapiens (human), Spliceosome - Homo sapiens (human), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA decay by 5' to 3' exoribonuclease
UniProt: P62310
Entrez ID: 27258
|
Does Knockout of HCN3 in Esophageal Squamous Cell Carcinoma Cell Line causally result in cell proliferation?
| 0
| 334
|
Knockout
|
HCN3
|
cell proliferation
|
Esophageal Squamous Cell Carcinoma Cell Line
|
Gene: HCN3 (hyperpolarization activated cyclic nucleotide gated potassium channel 3)
Type: protein-coding
Summary: This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: cellular response to cAMP, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of SA node cell action potential, regulation of heart rate by cardiac conduction, regulation of membrane depolarization, regulation of membrane potential, sodium ion import across plasma membrane, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: cAMP binding, monoatomic ion channel activity, nucleotide binding, potassium channel activity, protein binding, sodium channel activity, voltage-gated potassium channel activity, voltage-gated sodium channel activity; CC: HCN channel complex, axon, dendrite, membrane, monoatomic ion channel complex, plasma membrane
Pathways: GnRH secretion - Homo sapiens (human), HCN channels, Neuronal System, Potassium Channels
UniProt: Q9P1Z3
Entrez ID: 57657
|
Does Knockout of SNRPG in Lung Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 387
|
Knockout
|
SNRPG
|
cell proliferation
|
Lung Adenocarcinoma Cell Line
|
Gene: SNRPG (small nuclear ribonucleoprotein polypeptide G)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].
Gene Ontology: BP: 7-methylguanosine cap hypermethylation, RNA splicing, U2-type prespliceosome assembly, mRNA processing, mRNA splicing, via spliceosome, spliceosomal complex assembly, spliceosomal snRNP assembly; MF: RNA binding, protein binding; CC: P granule, SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type prespliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, cytoplasm, cytosol, methylosome, nucleoplasm, nucleus, precatalytic spliceosome, ribonucleoprotein complex, small nuclear ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex
Pathways: Disease, Gene expression (Transcription), Infectious disease, Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SARS-CoV Infections, SARS-CoV-2 Infection, SARS-CoV-2 modulates host translation machinery, SARS-CoV-2-host interactions, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Homo sapiens (human), Viral Infection Pathways, mRNA Processing, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62308
Entrez ID: 6637
|
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