prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Sap25 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Sap25
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Sap25 (sin3 associated polypeptide)
Type: protein-coding
Summary: Involved in negative regulation of DNA-templated transcription. Is active in nucleus. Orthologous to human SAP25 (Sin3A associated protein 25). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of DNA-templated transcription, regulation of DNA-templated transcription; CC: cytoplasm, nucleus
Pathways:
UniProt: Q1EHW4
Entrez ID: 751865
|
Does Knockout of Mitf in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Mitf
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Mitf (melanogenesis associated transcription factor)
Type: protein-coding
Summary: This transcription factor serves at a critical point between extracellular signaling and downstream targets in cell specification in early eye and neural crest development. Mutant alleles have been identified that generate distinct phenotypes. Some of these alleles are being used to model the human diseases Waardenburg syndrome IIa and Tietz syndrome. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: DNA-templated transcription, Wnt signaling pathway, bone remodeling, camera-type eye development, cell differentiation, cell fate commitment, melanocyte apoptotic process, melanocyte differentiation, negative regulation of apoptotic process, negative regulation of cell migration, negative regulation of transcription by RNA polymerase II, osteoclast differentiation, pigmentation, positive regulation of DNA-templated transcription, positive regulation of DNA-templated transcription initiation, positive regulation of gene expression, positive regulation of transcription by RNA polymerase II, protein-containing complex assembly, regulation of DNA-templated transcription, regulation of RNA biosynthetic process, regulation of cell population proliferation, regulation of gene expression, regulation of osteoclast differentiation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, chromatin binding, protein binding, protein dimerization activity, sequence-specific DNA binding; CC: cytoplasm, lysosomal membrane, lysosome, membrane, nucleoplasm, nucleus, protein-containing complex
Pathways: Developmental Biology, MITF-M-dependent gene expression, MITF-M-regulated melanocyte development, Melanogenesis - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Metabolism of proteins, Mitophagy - animal - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Post-translational protein modification, Regulation of MITF-M-dependent genes involved in apoptosis, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of transcription factors, Transcriptional and post-translational regulation of MITF-M expression and activity, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q08874
Entrez ID: 17342
|
Does Knockout of Mtif2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Mtif2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Mtif2 (mitochondrial translational initiation factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translational initiation, ribosome disassembly, translation, translational initiation; MF: GTP binding, GTPase activity, nucleotide binding, ribosomal small subunit binding, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, intracellular organelle lumen, mitochondrion, nucleoplasm
Pathways:
UniProt: Q91YJ5
Entrez ID: 76784
|
Does Knockout of Srgn in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Srgn
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Srgn (serglycin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell secretory granule organization, apoptotic process, biomineral tissue development, granzyme-mediated programmed cell death signaling pathway, maintenance of granzyme B location in T cell secretory granule, maintenance of protease location in mast cell secretory granule, mast cell secretory granule organization, negative regulation of bone mineralization, negative regulation of cytokine production, protein processing, secretory granule organization; MF: collagen binding, protein binding; CC: Golgi apparatus, Golgi membrane, cytolytic granule, extracellular region, extracellular space, lysosome, mast cell granule, secretory granule, zymogen granule
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: P13609
Entrez ID: 19073
|
Does Knockout of Med4 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Med4
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Med4 (mediator complex subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of DNA-templated transcription, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: nuclear thyroid hormone receptor binding, protein binding, transcription coactivator activity, transcription coregulator activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus
Pathways: Thyroid hormone signaling pathway - Mus musculus (mouse)
UniProt: Q9CQA5
Entrez ID: 67381
|
Does Knockout of Ccnb2 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Ccnb2
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ccnb2 (cyclin B2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G1/S transition of mitotic cell cycle, G2/MI transition of meiotic cell cycle, T cell homeostasis, cell division, in utero embryonic development, mitotic cell cycle phase transition, regulation of growth, spindle assembly involved in female meiosis I, thymus development; MF: cyclin-dependent protein serine/threonine kinase regulator activity, protein binding; CC: centrosome, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, cytosol, membrane, microtubule cytoskeleton, microtubule organizing center, nucleus
Pathways: Activation of NIMA Kinases NEK9, NEK6, NEK7, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Cyclin A/B1/B2 associated events during G2/M transition, FoxO signaling pathway - Mus musculus (mouse), G2/M Checkpoints, G2/M DNA replication checkpoint, G2/M Transition, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Initiation of Nuclear Envelope (NE) Reformation, M Phase, Mitotic Anaphase, Mitotic G2-G2/M phases, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Prophase, Nuclear Envelope (NE) Reassembly, Nuclear Envelope Breakdown, Nuclear Pore Complex (NPC) Disassembly, Oocyte meiosis - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of PLK1 Activity at G2/M Transition, Resolution of Sister Chromatid Cohesion, The role of GTSE1 in G2/M progression after G2 checkpoint, p53 signaling pathway - Mus musculus (mouse)
UniProt: P30276
Entrez ID: 12442
|
Does Knockout of Ankrd10 in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Ankrd10
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Ankrd10 (ankyrin repeat domain 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleoplasm
Pathways:
UniProt: Q99LW0
Entrez ID: 102334
|
Does Knockout of Gkn3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Gkn3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gkn3 (gastrokine 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of epithelial cell proliferation, regulation of cell population proliferation; CC: extracellular region, extracellular space
Pathways:
UniProt: Q9D0T7
Entrez ID: 68888
|
Does Knockout of Gga1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Gga1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gga1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi to plasma membrane transport, intracellular protein localization, intracellular protein transport, positive regulation of protein catabolic process, protein localization to cell periphery, protein localization to cell surface, protein localization to ciliary membrane, protein localization to membrane, protein transport, retrograde transport, endosome to Golgi, vesicle-mediated transport; MF: phosphatidylinositol binding, protein binding, small GTPase binding, ubiquitin binding; CC: Golgi apparatus, cytosol, early endosome, early endosome membrane, endosome, endosome membrane, membrane, nucleoplasm, protein-containing complex, trans-Golgi network
Pathways: Lysosome - Mus musculus (mouse)
UniProt: Q8R0H9
Entrez ID: 106039
|
Does Knockout of Gm14819 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Gm14819
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Gm14819 (predicted gene 14819)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: nucleus
Pathways:
UniProt: Q62478
Entrez ID: 100039585
|
Does Knockout of Serhl in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Serhl
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Serhl (serine hydrolase-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: hydrolase activity; CC: cytoplasm, cytoplasmic vesicle, mitochondrion, perinuclear region of cytoplasm, peroxisome
Pathways:
UniProt: Q9EPB5
Entrez ID: 68607
|
Does Knockout of Tmem107 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Tmem107
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tmem107 (transmembrane protein 107)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium assembly, cilium organization, craniofacial suture morphogenesis, detection of nodal flow, determination of left/right symmetry, embryonic digit morphogenesis, neural tube patterning, non-motile cilium assembly, protein localization to ciliary transition zone, regulation of gene expression, roof of mouth development; CC: MKS complex, cell projection, ciliary transition zone, cilium, membrane
Pathways:
UniProt: Q9CPV0
Entrez ID: 66910
|
Does Knockout of 1700020N15Rik in Embryonic Fibroblast Cell Line causally result in autophagy?
| 1
| 1,044
|
Knockout
|
1700020N15Rik
|
autophagy
|
Embryonic Fibroblast Cell Line
|
Gene: 1700020N15Rik (RIKEN cDNA 1700020N15 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 75509
|
Does Knockout of Kmt2e in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 165
|
Knockout
|
Kmt2e
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Kmt2e (lysine (K)-specific methyltransferase 2E)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, chromatin remodeling, epigenetic regulation of gene expression, erythrocyte differentiation, neutrophil activation, neutrophil mediated immunity, positive regulation of DNA-templated transcription, positive regulation of G1/S transition of mitotic cell cycle, regulation of DNA-templated transcription, regulation of cell cycle, regulation of gene expression, retinoic acid receptor signaling pathway; MF: enzyme binding, histone H3K4 methyltransferase activity, histone H3K4me3 reader activity, metal ion binding, transcription coactivator activity, zinc ion binding; CC: Rpd3L-Expanded complex, Set3 complex, centrosome, chromatin, chromosome, cytoplasm, cytoskeleton, euchromatin, nuclear body, nuclear speck, nucleoplasm, nucleus, protein-containing complex
Pathways: Lysine degradation - Mus musculus (mouse)
UniProt: Q3UG20
Entrez ID: 69188
|
Does Knockout of Rif1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Rif1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rif1 (replication timing regulatory factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, cellular response to leukemia inhibitory factor, negative regulation of double-strand break repair via homologous recombination, negative regulation of gene expression, epigenetic, negative regulation of transcription by RNA polymerase II, positive regulation of double-strand break repair via nonhomologous end joining, positive regulation of isotype switching, somatic stem cell population maintenance, subtelomeric heterochromatin formation, telomere maintenance, telomere maintenance in response to DNA damage; CC: chromatin, chromosome, chromosome, telomeric region, chromosome, telomeric repeat region, condensed chromosome, cytoplasm, cytoskeleton, female pronucleus, male pronucleus, nuclear membrane, nucleoplasm, nucleus, plasma membrane, site of double-strand break, spindle, spindle midzone
Pathways: DNA Double-Strand Break Repair, DNA Repair, Nonhomologous End-Joining (NHEJ), Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse)
UniProt: Q6PR54
Entrez ID: 51869
|
Does Knockout of Eif2b3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Eif2b3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Eif2b3 (eukaryotic translation initiation factor 2B, subunit 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, central nervous system development, cytoplasmic translational initiation, oligodendrocyte development, response to glucose, response to heat, response to peptide hormone, translation, translational initiation; MF: guanyl-nucleotide exchange factor activity, translation factor activity, RNA binding, translation initiation factor activity; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2B complex
Pathways: Cap-dependent Translation Initiation, Eukaryotic Translation Initiation, Herpes simplex virus 1 infection - Mus musculus (mouse), Metabolism of proteins, Recycling of eIF2:GDP, Translation
UniProt: B1AUN2, Q3UKV0, B1AUN3
Entrez ID: 108067
|
Does Knockout of Vmn1r222 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Vmn1r222
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r222 (vomeronasal 1 receptor 222)
Type: protein-coding
Summary: Predicted to enable pheromone binding activity and pheromone receptor activity. Predicted to act upstream of or within response to pheromone. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R269
Entrez ID: 171274
|
Does Knockout of Wrap73 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Wrap73
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Wrap73 (WD repeat containing, antisense to Trp73)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, mitotic spindle assembly, positive regulation of non-motile cilium assembly; CC: MWP complex, centrosome, ciliary basal body, cytoplasm, cytoskeleton, microtubule organizing center
Pathways:
UniProt: Q9JM98
Entrez ID: 59002
|
Does Knockout of Ppp1r7 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Ppp1r7
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ppp1r7 (protein phosphatase 1, regulatory subunit 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: protein binding, protein phosphatase regulator activity; CC: chromosome, nucleus
Pathways:
UniProt: Q3UM45
Entrez ID: 66385
|
Does Knockout of Snx14 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Snx14
|
response to virus
|
Microglial Cell Line
|
Gene: Snx14 (sorting nexin 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, postsynaptic modulation of chemical synaptic transmission, protein transport; MF: phosphatidylinositol binding, phosphatidylinositol-3,5-bisphosphate binding; CC: cell projection, cytosol, dendrite, endosome, late endosome, late endosome membrane, lysosomal membrane, lysosome, membrane, postsynapse, synapse
Pathways:
UniProt: Q8BHY8
Entrez ID: 244962
|
Does Knockout of Casp14 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Casp14
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Casp14 (caspase 14)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, positive regulation of neuron apoptotic process, proteolysis; MF: cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity; CC: cornified envelope, cytoplasm, cytosol, keratin filament, mitochondrion, nucleoplasm, nucleus
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: O89094
Entrez ID: 12365
|
Does Knockout of Mzt1 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,267
|
Knockout
|
Mzt1
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mzt1 (mitotic spindle organizing protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: gamma-tubulin complex localization, microtubule nucleation by interphase microtubule organizing center, mitotic spindle assembly; CC: centrosome, cytoplasm, cytoskeleton, gamma-tubulin ring complex, interphase microtubule organizing center, spindle
Pathways: Cell Cycle, Cell Cycle, Mitotic, Centrosome maturation, G2/M Transition, M Phase, Mitotic G2-G2/M phases, Mitotic Prometaphase, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes
UniProt: Q8BUR9
Entrez ID: 76789
|
Does Knockout of Oas1f in Mouse cell causally result in protein/peptide accumulation?
| 0
| 1,047
|
Knockout
|
Oas1f
|
protein/peptide accumulation
|
Mouse cell
|
Gene: Oas1f (2'-5' oligoadenylate synthetase 1F)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, cellular response to exogenous dsRNA, cellular response to interferon-alpha, cellular response to interferon-beta, defense response to bacterium, defense response to virus, glucose homeostasis, glucose metabolic process, immune system process, innate immune response, interleukin-27-mediated signaling pathway, negative regulation of IP-10 production, negative regulation of chemokine (C-X-C motif) ligand 2 production, negative regulation of type I interferon-mediated signaling pathway, negative regulation of viral genome replication, positive regulation of cellular respiration, positive regulation of interferon-beta production, positive regulation of monocyte chemotactic protein-1 production, positive regulation of tumor necrosis factor production, protein complex oligomerization, response to virus, surfactant homeostasis, toll-like receptor 3 signaling pathway, toll-like receptor 4 signaling pathway, type I interferon-mediated signaling pathway; MF: 2'-5'-oligoadenylate synthetase activity, RNA binding, double-stranded RNA binding, nucleotidyltransferase activity; CC: cytoplasm, cytosol, membrane, mitochondrion, nucleoplasm, nucleus, ribosome
Pathways:
UniProt: F7AC31, Q14AZ4
Entrez ID: 243262
|
Does Knockout of Rfc3 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Rfc3
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Rfc3 (replication factor C (activator 1) 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, DNA replication, DNA strand elongation involved in DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP-dependent activity, acting on DNA, DNA binding, DNA clamp loader activity, protein binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, chromosome, nucleus, protein-containing complex
Pathways: Activation of ATR in response to replication stress, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q8R323
Entrez ID: 69263
|
Does Knockout of Med28 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Med28
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Med28 (mediator complex subunit 28)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, negative regulation of smooth muscle cell differentiation, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, somatic stem cell population maintenance; MF: actin binding, protein binding; CC: core mediator complex, cortical actin cytoskeleton, cytoplasm, cytoskeleton, mediator complex, membrane, nucleoplasm, nucleus
Pathways:
UniProt: Q920D3
Entrez ID: 66999
|
Does Knockout of Dclk2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Dclk2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dclk2 (doublecortin-like kinase 2)
Type: protein-coding
Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmoduline-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. This gene and the DCX gene, another family member, share function in the establishment of hippocampal organization and their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010].
Gene Ontology: BP: central nervous system neuron development, hippocampus development, intracellular signal transduction, microtubule cytoskeleton organization, negative regulation of protein localization to nucleus, protein localization to nucleus, pyramidal neuron development; MF: ATP binding, kinase activity, microtubule binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytoskeleton
Pathways:
UniProt: Q6PGN3
Entrez ID: 70762
|
Does Knockout of Cdc26 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,278
|
Knockout
|
Cdc26
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cdc26 (cell division cycle 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell division, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, regulation of mitotic cell cycle; CC: anaphase-promoting complex, nucleus
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q99JP4
Entrez ID: 66440
|
Does Knockout of Hnrnpk in Regulatory T cell causally result in protein/peptide accumulation?
| 1
| 1,570
|
Knockout
|
Hnrnpk
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Hnrnpk (heterogeneous nuclear ribonucleoprotein K)
Type: protein-coding
Summary: The protein encoded by this gene is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a poly-cytosine binding protein (PCBP). It is found in multiple subcellular compartments including the nucleus, cytoplasm and mitochondria. This gene product is thought to interact with RNA, DNA, and protein, and is involved in multiple cellular processes, including transcription, chromatin remodeling, DNA damage response, signal transduction, mRNA splicing, export, and translation. Multiple transcript variants and protein isoforms exist, with some isoforms containing a unique C-terminus. There are four pseudogenes of this gene, found on chromosomes 2, 3, 7 and 13. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: RNA splicing, mRNA processing, negative regulation of DNA-templated transcription, negative regulation of RNA metabolic process, negative regulation of apoptotic process, negative regulation of gene expression, negative regulation of mRNA splicing, via spliceosome, positive regulation of low-density lipoprotein particle clearance, positive regulation of transcription by RNA polymerase II, random inactivation of X chromosome, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of apoptotic process, regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, regulation of mRNA splicing, via spliceosome, regulation of transcription by RNA polymerase II, regulatory ncRNA-mediated heterochromatin formation; MF: ATPase binding, C-rich single-stranded DNA binding, DNA binding, RNA binding, actinin binding, cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, heat shock protein binding, identical protein binding, lamin binding, mRNA 3'-UTR binding, mRNA CDS binding, mRNA binding, nucleic acid binding, pre-mRNA 3'-splice site binding, protein binding, protein domain specific binding, ribonucleoprotein complex binding, single-stranded DNA binding; CC: anchoring junction, axon terminus, catalytic step 2 spliceosome, cell cortex, cell projection, chromatin, cytoplasm, cytoplasmic stress granule, dendritic spine, glutamatergic synapse, nucleoplasm, nucleus, podosome, postsynapse, protein-DNA complex, ribonucleoprotein complex, spliceosomal complex
Pathways: Metabolism of RNA, Metabolism of proteins, MicroRNAs in cancer - Mus musculus (mouse), Post-translational protein modification, Processing of Capped Intron-Containing Pre-mRNA, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of RNA binding proteins, Spliceosome - Mus musculus (mouse), Viral carcinogenesis - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: P61979
Entrez ID: 15387
|
Does Knockout of Icosl in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Icosl
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Icosl (icos ligand)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: B cell activation, T cell activation, T cell receptor signaling pathway, T follicular helper cell differentiation, adaptive immune response, immune system process, isotype switching, positive regulation of activated T cell proliferation, positive regulation of interleukin-4 production, regulation of cytokine production, signal transduction; MF: identical protein binding, protein binding, receptor ligand activity, signaling receptor binding; CC: external side of plasma membrane, membrane, plasma membrane
Pathways: Adaptive Immune System, Cell adhesion molecules - Mus musculus (mouse), Co-stimulation by ICOS, Immune System, Intestinal immune network for IgA production - Mus musculus (mouse), Regulation of T cell activation by CD28 family
UniProt: Q9JHJ8
Entrez ID: 50723
|
Does Knockout of Sdhaf2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Sdhaf2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sdhaf2 (succinate dehydrogenase complex assembly factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial electron transport, succinate to ubiquinone, mitochondrial respiratory chain complex II assembly, negative regulation of canonical Wnt signaling pathway, negative regulation of epithelial to mesenchymal transition, protein-FAD linkage, tricarboxylic acid cycle; CC: cytosol, mitochondrial matrix, mitochondrion, nucleolus
Pathways: Aerobic respiration and respiratory electron transport, Citric acid cycle (TCA cycle), Maturation of TCA enzymes and regulation of TCA cycle, Metabolism
UniProt: Q8C6I2
Entrez ID: 66072
|
Does Knockout of Ugt1a10 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Ugt1a10
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ugt1a10 (UDP glycosyltransferase 1 family, polypeptide A10)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: Ascorbate and aldarate metabolism - Mus musculus (mouse), Bile secretion - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Drug metabolism - cytochrome P450 - Mus musculus (mouse), Drug metabolism - other enzymes - Mus musculus (mouse), Metabolism of xenobiotics by cytochrome P450 - Mus musculus (mouse), Pentose and glucuronate interconversions - Mus musculus (mouse), Porphyrin and chlorophyll metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse)
UniProt: Q6XL43, E9PXN7, Q5FW80, G3UZC9, D3Z7G0
Entrez ID: 394430
|
Does Knockout of Kcnj13 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Kcnj13
|
response to virus
|
Microglial Cell Line
|
Gene: Kcnj13 (potassium inwardly-rectifying channel, subfamily J, member 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion import across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of monoatomic ion transmembrane transport; MF: inward rectifier potassium channel activity, potassium channel activity; CC: membrane, monoatomic ion channel complex, plasma membrane
Pathways: Protein digestion and absorption - Mus musculus (mouse)
UniProt: P86046
Entrez ID: 100040591
|
Does Knockout of Rps9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Rps9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rps9 (ribosomal protein S9)
Type: protein-coding
Summary: A structural constituent of ribosome. Predicted to be involved in positive regulation of cell population proliferation; ribosomal small subunit biogenesis; and translation. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in several structures, including cerebral cortex; diaphragm; eye; genitourinary system; and soleus. Orthologous to human RPS9 (ribosomal protein S9). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cytoplasmic translation, ribosomal small subunit biogenesis, translation; MF: 5.8S rRNA binding, RNA binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q6ZWN5
Entrez ID: 76846
|
Does Knockout of Sim1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Sim1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Sim1 (single-minded family bHLH transcription factor 1)
Type: protein-coding
Summary: Enables protein heterodimerization activity. Involved in ureteric bud development. Acts upstream of or within regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; future brain; genitourinary system; and sensory organ. Used to study obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SIM1 (SIM bHLH transcription factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, nervous system development, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, system development, ureteric bud development; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, protein dimerization activity, protein heterodimerization activity; CC: nucleus
Pathways:
UniProt: Q61045
Entrez ID: 20464
|
Does Knockout of Bet1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Bet1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bet1 (Bet1 golgi vesicular membrane trafficking protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, protein transport, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, syntaxin binding; CC: Golgi apparatus, Golgi cis cisterna, Golgi cisterna, Golgi membrane, SNARE complex, cis-Golgi network, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, ER to Golgi Anterograde Transport, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, SNARE interactions in vesicular transport - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: O35623
Entrez ID: 12068
|
Does Knockout of Ube2g2 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Ube2g2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ube2g2 (ubiquitin-conjugating enzyme E2G 2)
Type: protein-coding
Summary: Enables identical protein binding activity and ubiquitin conjugating enzyme activity. Acts upstream of or within ERAD pathway. Located in cytosol and endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human UBE2G2 (ubiquitin conjugating enzyme E2 G2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: ERAD pathway, cellular response to interferon-beta, negative regulation of retrograde protein transport, ER to cytosol, protein K48-linked ubiquitination, protein catabolic process, protein polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; MF: ATP binding, identical protein binding, nucleotide binding, protein binding, transferase activity, ubiquitin conjugating enzyme activity, ubiquitin-protein transferase activity; CC: cytosol, endoplasmic reticulum, lipid droplet
Pathways: Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Class I MHC mediated antigen processing & presentation, Immune System, Metabolism of proteins, Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Protein ubiquitination, Synthesis of active ubiquitin: roles of E1 and E2 enzymes, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: P60605
Entrez ID: 22213
|
Does Knockout of Mcoln3 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 2,492
|
Knockout
|
Mcoln3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mcoln3 (mucolipin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: calcium-mediated signaling, inner ear auditory receptor cell differentiation, locomotory behavior, monoatomic anion transmembrane transport, monoatomic cation transmembrane transport, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, sodium ion transmembrane transport; MF: NAADP-sensitive calcium-release channel activity, lipid binding, monoatomic anion channel activity, monoatomic cation channel activity, monoatomic cation transmembrane transporter activity, potassium channel activity, sodium channel activity; CC: autophagosome membrane, cell projection, cytoplasm, cytoplasmic vesicle, early endosome membrane, endosome, late endosome membrane, lysosomal membrane, membrane, plasma membrane, stereocilium membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Ion channel transport, Stimuli-sensing channels, TRP channels, Transport of small molecules
UniProt: Q8R4F0
Entrez ID: 171166
|
Does Knockout of Smok3a in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Smok3a
|
cell cycle progression
|
breast epithelium
|
Gene: Smok3a (sperm motility kinase 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways:
UniProt: C0HKC8
Entrez ID: 545814
|
Does Knockout of Gle1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Gle1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gle1 (GLE1 RNA export mediator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA export from nucleus, mRNA transport, nucleocytoplasmic transport, poly(A)+ mRNA export from nucleus, protein transport; MF: identical protein binding, inositol hexakisphosphate binding, phospholipid binding, translation initiation factor binding; CC: centriole, centrosome, ciliary basal body, cytoplasm, cytosol, nuclear envelope, nuclear membrane, nuclear pore, nuclear pore cytoplasmic filaments, nucleolus, nucleus
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Metabolism of RNA, Nucleocytoplasmic transport - Mus musculus (mouse), Processing of Capped Intron-Containing Pre-mRNA, Transport of Mature Transcript to Cytoplasm, Transport of Mature mRNA derived from an Intron-Containing Transcript, mRNA surveillance pathway - Mus musculus (mouse)
UniProt: Q8R322
Entrez ID: 74412
|
Does Knockout of Ddx21 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 1
| 2,307
|
Knockout
|
Ddx21
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Ddx21 (DExD box helicase 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: R-loop processing, chromatin remodeling, defense response to virus, immune system process, innate immune response, positive regulation of canonical NF-kappaB signal transduction, positive regulation of macromolecule biosynthetic process, positive regulation of myeloid dendritic cell cytokine production, positive regulation of transcription by RNA polymerase I, positive regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase III, rRNA processing, regulation of gene expression, response to exogenous dsRNA, response to virus, transcription by RNA polymerase II; MF: 7SK snRNA binding, ATP binding, ATP hydrolysis activity, RNA binding, RNA helicase activity, double-stranded RNA binding, helicase activity, hydrolase activity, identical protein binding, mRNA binding, miRNA binding, nucleic acid binding, nucleotide binding, protein binding, rRNA binding, snoRNA binding; CC: B-WICH complex, chromosome, cytoplasm, cytosol, mitochondrion, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Positive epigenetic regulation of rRNA expression, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9JIK5
Entrez ID: 56200
|
Does Knockout of Pde10a in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,174
|
Knockout
|
Pde10a
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Pde10a (phosphodiesterase 10A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cAMP catabolic process, cGMP catabolic process, negative regulation of cAMP/PKA signal transduction, negative regulation of cGMP-mediated signaling, regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway, regulation of cAMP/PKA signal transduction, signal transduction; MF: 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity, 3',5'-cyclic-AMP phosphodiesterase activity, 3',5'-cyclic-GMP phosphodiesterase activity, 3',5'-cyclic-nucleotide phosphodiesterase activity, cAMP binding, cGMP binding, catalytic activity, cyclic-nucleotide phosphodiesterase activity, hydrolase activity, metal ion binding, nucleotide binding, phosphoric diester hydrolase activity; CC: cytoplasm, cytosol, extrinsic component of postsynaptic density membrane, glutamatergic synapse, neuronal cell body, perikaryon, synapse
Pathways: G alpha (s) signalling events, GPCR downstream signalling, Hemostasis, Morphine addiction - Mus musculus (mouse), Nitric oxide stimulates guanylate cyclase, Platelet homeostasis, Purine metabolism - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse), cGMP effects
UniProt: Q8CA95
Entrez ID: 23984
|
Does Knockout of Ybx1 in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 684
|
Knockout
|
Ybx1
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Ybx1 (Y box protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CRD-mediated mRNA stabilization, RNA splicing, RNA transport, cellular response to interleukin-7, embryonic morphogenesis, epidermis development, in utero embryonic development, mRNA processing, mRNA stabilization, miRNA transport, negative regulation of RNA metabolic process, negative regulation of cellular senescence, negative regulation of macromolecule biosynthetic process, negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, negative regulation of striated muscle cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of translation, positive regulation of cell division, positive regulation of cytoplasmic translation, positive regulation of transcription by RNA polymerase II, protein localization to cytoplasmic stress granule, regulation of DNA-templated transcription, regulation of gene expression, tRNA transport; MF: C5-methylcytidine-containing RNA reader activity, DNA binding, GTPase binding, RNA binding, chromatin binding, mRNA binding, miRNA binding, nucleic acid binding, p53 binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, single-stranded DNA binding; CC: CRD-mediated mRNA stability complex, P-body, U12-type spliceosomal complex, cytoplasm, cytoplasmic stress granule, cytosol, dendrite, endoplasmic reticulum, extracellular exosome, extracellular region, histone pre-mRNA 3'end processing complex, neuronal cell body, nucleus, perinuclear region of cytoplasm, plasma membrane, protein-containing complex, ribonucleoprotein complex, synapse
Pathways: Cytokine Signaling in Immune system, Immune System, Interferon Signaling, Interferon gamma signaling, Metabolism of RNA, NOTCH3 Activation and Transmission of Signal to the Nucleus, Noncanonical activation of NOTCH3, Processing of Capped Intron-Containing Pre-mRNA, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH3, mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway
UniProt: P62960
Entrez ID: 22608
|
Does Knockout of Spa17 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Spa17
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Spa17 (sperm autoantigenic protein 17)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, single fertilization; CC: cilium, cytoplasm, external side of plasma membrane, membrane, motile cilium, neuron projection, sperm fibrous sheath, sperm principal piece
Pathways:
UniProt: Q62252
Entrez ID: 20686
|
Does Knockout of Srsf12 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Srsf12
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Srsf12 (serine and arginine-rich splicing factor 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA 5'-splice site recognition, mRNA processing, regulation of alternative mRNA splicing, via spliceosome
Pathways:
UniProt: Q8C8K3
Entrez ID: 272009
|
Does Knockout of Unc45a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Unc45a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Unc45a (unc-45 myosin chaperone A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, muscle organ development, protein folding; MF: Hsp90 protein binding, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, nuclear speck, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q99KD5
Entrez ID: 101869
|
Does Knockout of Cd79a in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Cd79a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Cd79a (CD79A antigen (immunoglobulin-associated alpha))
Type: protein-coding
Summary: Enables transmembrane signaling receptor activity. Involved in B cell differentiation; B cell proliferation; and B cell receptor signaling pathway. Located in external side of plasma membrane; membrane raft; and multivesicular body. Part of B cell receptor complex. Is expressed in liver. Human ortholog(s) of this gene implicated in agammaglobulinemia 3. Orthologous to human CD79A (CD79a molecule). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: B cell activation, B cell differentiation, B cell proliferation, B cell receptor signaling pathway, adaptive immune response, cell surface receptor signaling pathway, immune system process; MF: identical protein binding, protein binding, transmembrane signaling receptor activity; CC: B cell receptor complex, IgM B cell receptor complex, external side of plasma membrane, membrane, membrane raft, multivesicular body, plasma membrane
Pathways: Adaptive Immune System, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, B cell receptor signaling pathway - Mus musculus (mouse), CD22 mediated BCR regulation, Immune System, Primary immunodeficiency - Mus musculus (mouse), Signaling by the B Cell Receptor (BCR)
UniProt: P11911
Entrez ID: 12518
|
Does Knockout of Anapc2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Anapc2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Anapc2 (anaphase promoting complex subunit 2)
Type: protein-coding
Summary: This gene encodes a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle by ubiquitinating its specific substrates, such as mitotic cyclins and anaphase inhibitor, for subsequent degradation by the proteasome. [provided by RefSeq, Oct 2009].
Gene Ontology: BP: anaphase-promoting complex-dependent catabolic process, cell differentiation, cell division, metaphase/anaphase transition of mitotic cell cycle, negative regulation of gene expression, nervous system development, positive regulation of axon extension, positive regulation of dendrite morphogenesis, positive regulation of synapse maturation, positive regulation of synaptic plasticity, protein K11-linked ubiquitination, protein K48-linked ubiquitination, protein branched polyubiquitination, protein ubiquitination, ubiquitin-dependent protein catabolic process; CC: anaphase-promoting complex
Pathways: APC-Cdc20 mediated degradation of Nek2A, APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Cyclin B, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1, APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint, Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, Adaptive Immune System, Antigen processing: Ubiquitination & Proteasome degradation, Assembly of the pre-replicative complex, Autodegradation of Cdh1 by Cdh1:APC/C, CDK-mediated phosphorylation and removal of Cdc6, Cdc20:Phospho-APC/C mediated degradation of Cyclin A, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Cell cycle - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Class I MHC mediated antigen processing & presentation, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase, DNA Replication, DNA Replication Pre-Initiation, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Immune System, Inactivation of APC/C via direct inhibition of the APC/C complex, Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Spindle Checkpoint, Oocyte meiosis - Mus musculus (mouse), Phosphorylation of the APC/C, Progesterone-mediated oocyte maturation - Mus musculus (mouse), Regulation of APC/C activators between G1/S and early anaphase, Regulation of mitotic cell cycle, S Phase, Senescence-Associated Secretory Phenotype (SASP), Separation of Sister Chromatids, Switching of origins to a post-replicative state, Synthesis of DNA, Targeted protein degradation, Ubiquitin mediated proteolysis - Mus musculus (mouse)
UniProt: Q8BZQ7
Entrez ID: 99152
|
Does Knockout of Jak2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Jak2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Jak2 (Janus kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, activation of Janus kinase activity, adaptive immune response, apoptotic signaling pathway, axon regeneration, cell adhesion, cell differentiation, cell surface receptor signaling pathway via JAK-STAT, cellular response to dexamethasone stimulus, cellular response to interleukin-3, cellular response to lipopolysaccharide, cellular response to steroid hormone stimulus, chromatin organization, chromatin remodeling, collagen-activated signaling pathway, cytokine-mediated signaling pathway, defense response to symbiont, enzyme-linked receptor protein signaling pathway, erythrocyte differentiation, erythropoietin-mediated signaling pathway, extrinsic apoptotic signaling pathway, granulocyte-macrophage colony-stimulating factor signaling pathway, growth hormone receptor signaling pathway, growth hormone receptor signaling pathway via JAK-STAT, hormone-mediated signaling pathway, immune response, immune system process, innate immune response, interleukin-12-mediated signaling pathway, interleukin-23-mediated signaling pathway, interleukin-3-mediated signaling pathway, interleukin-5-mediated signaling pathway, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to oxidative stress, lipopolysaccharide-mediated signaling pathway, mammary gland epithelium development, microglial cell activation, modulation of chemical synaptic transmission, myeloid cell differentiation, negative regulation of 3'-UTR-mediated mRNA stabilization, negative regulation of apoptotic process, negative regulation of cardiac muscle cell apoptotic process, negative regulation of cell population proliferation, negative regulation of cell-cell adhesion, negative regulation of cytokine production involved in inflammatory response, negative regulation of growth hormone receptor signaling pathway, negative regulation of neuron apoptotic process, nuclear receptor-mediated mineralocorticoid signaling pathway, platelet-derived growth factor receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of MHC class II biosynthetic process, positive regulation of NK T cell proliferation, positive regulation of SMAD protein signal transduction, positive regulation of T cell proliferation, positive regulation of T-helper 17 type immune response, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, positive regulation of cell activation, positive regulation of cell differentiation, positive regulation of cell migration, positive regulation of cell population proliferation, positive regulation of cell-substrate adhesion, positive regulation of cold-induced thermogenesis, positive regulation of cytosolic calcium ion concentration, positive regulation of epithelial cell apoptotic process, positive regulation of growth factor dependent skeletal muscle satellite cell proliferation, positive regulation of growth hormone receptor signaling pathway, positive regulation of insulin secretion, positive regulation of interleukin-1 beta production, positive regulation of interleukin-17 production, positive regulation of intracellular signal transduction, positive regulation of leukocyte proliferation, positive regulation of natural killer cell proliferation, positive regulation of nitric oxide biosynthetic process, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of platelet activation, positive regulation of platelet aggregation, positive regulation of protein import into nucleus, positive regulation of receptor signaling pathway via JAK-STAT, positive regulation of transcription by RNA polymerase II, positive regulation of tumor necrosis factor production, positive regulation of type II interferon production, positive regulation of tyrosine phosphorylation of STAT protein, positive regulation of vascular associated smooth muscle cell proliferation, post-embryonic hemopoiesis, post-translational protein modification, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autophosphorylation, regulation of T cell activation, regulation of apoptotic process, regulation of inflammatory response, regulation of leukocyte cell-cell adhesion, regulation of nitric oxide biosynthetic process, regulation of postsynapse to nucleus signaling pathway, response to antibiotic, response to granulocyte macrophage colony-stimulating factor, response to hydroperoxide, response to interleukin-12, response to oxidative stress, response to tumor necrosis factor, signal transduction, symbiont-induced defense-related programmed cell death, thrombopoietin-mediated signaling pathway, tumor necrosis factor-mediated signaling pathway, type II interferon-mediated signaling pathway; MF: ATP binding, SH2 domain binding, acetylcholine receptor binding, cytokine receptor binding, growth hormone receptor binding, heme binding, histone H3Y41 kinase activity, histone binding, identical protein binding, insulin receptor substrate binding, interleukin-12 receptor binding, kinase activity, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding, peptide hormone receptor binding, phosphatidylinositol 3-kinase binding, protein binding, protein kinase activity, protein kinase binding, protein tyrosine kinase activity, signaling receptor activator activity, signaling receptor binding, transferase activity, type 1 angiotensin receptor binding; CC: caveola, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endomembrane system, euchromatin, extrinsic component of cytoplasmic side of plasma membrane, extrinsic component of plasma membrane, focal adhesion, glutamatergic synapse, granulocyte macrophage colony-stimulating factor receptor complex, interleukin-12 receptor complex, interleukin-23 receptor complex, membrane, membrane raft, nucleoplasm, nucleus, plasma membrane, postsynapse
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Adipocytokine signaling pathway - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Cyclin D associated events in G1, Cytokine Signaling in Immune system, Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Erythropoietin activates RAS, Factors involved in megakaryocyte development and platelet production, G1 Phase, Growth hormone receptor signaling, Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), IFNG signaling activates MAPKs, IL-6-type cytokine receptor ligand interactions, Immune System, Inactivation of CSF3 (G-CSF) signaling, Influenza A - Mus musculus (mouse), Interferon Signaling, Interferon gamma signaling, Interleukin receptor SHC signaling, Interleukin-12 family signaling, Interleukin-12 signaling, Interleukin-2 family signaling, Interleukin-20 family signaling, Interleukin-23 signaling, Interleukin-27 signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Interleukin-35 Signalling, Interleukin-4 and Interleukin-13 signaling, Interleukin-6 family signaling, Interleukin-6 signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leishmaniasis - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK family signaling cascades, MAPK1 (ERK2) activation, MAPK1/MAPK3 signaling, MAPK3 (ERK1) activation, Mitotic G1 phase and G1/S transition, Necroptosis - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Prolactin receptor signaling, Prolactin signaling pathway - Mus musculus (mouse), RAF activation, RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Regulation of IFNG signaling, Signal Transduction, Signaling by CSF3 (G-CSF), Signaling by Erythropoietin, Signaling by Interleukins, Signaling by Receptor Tyrosine Kinases, Signaling by SCF-KIT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse)
UniProt: Q62120
Entrez ID: 16452
|
Does Knockout of Dctn3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Dctn3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dctn3 (dynactin 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, cytoskeleton-dependent cytokinesis, microtubule-based process; CC: centrosome, chromosome, chromosome, centromeric region, cleavage furrow, cytoplasm, cytoskeleton, cytosol, dynactin complex, kinetochore, microtubule, microtubule associated complex, midbody, nucleolus, perinuclear region of cytoplasm, spindle
Pathways: AURKA Activation by TPX2, Adaptive Immune System, Amyotrophic lateral sclerosis - Mus musculus (mouse), Anchoring of the basal body to the plasma membrane, Asparagine N-linked glycosylation, COPI-independent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, Cell Cycle, Cell Cycle, Mitotic, Cellular responses to stimuli, Cellular responses to stress, Centrosome maturation, Cilium Assembly, ER to Golgi Anterograde Transport, G2/M Transition, Golgi-to-ER retrograde transport, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand, Huntington disease - Mus musculus (mouse), Immune System, Intra-Golgi and retrograde Golgi-to-ER traffic, Loss of Nlp from mitotic centrosomes, Loss of proteins required for interphase microtubule organization from the centrosome, M Phase, MHC class II antigen presentation, Membrane Trafficking, Metabolism of proteins, Mitotic G2-G2/M phases, Mitotic Prometaphase, Organelle biogenesis and maintenance, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Recruitment of NuMA to mitotic centrosomes, Recruitment of mitotic centrosome proteins and complexes, Regulation of PLK1 Activity at G2/M Transition, Salmonella infection - Mus musculus (mouse), Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q9Z0Y1
Entrez ID: 53598
|
Does Knockout of Taf1a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Taf1a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Taf1a (TATA-box binding protein associated factor, RNA polymerase I, A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: transcription by RNA polymerase I; MF: DNA binding, protein binding; CC: RNA polymerase I transcription regulator complex, RNA polymerase transcription factor SL1 complex, microtubule cytoskeleton, nucleolus, nucleoplasm, nucleus
Pathways: B-WICH complex positively regulates rRNA expression, Epigenetic regulation of gene expression, Gene expression (Transcription), Positive epigenetic regulation of rRNA expression, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination
UniProt: P97357
Entrez ID: 21339
|
Does Knockout of Nudc in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Nudc
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Nudc (nudC nuclear distribution protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell division, establishment of organelle localization, mitotic metaphase chromosome alignment, mitotic spindle organization, nuclear migration, protein folding, response to peptide hormone; MF: protein binding, unfolded protein binding; CC: cytoplasm, cytoskeleton, cytosol, microtubule, midbody, mitotic spindle, nucleus, spindle
Pathways: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal, Amplification of signal from the kinetochores, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, EML4 and NUDC in mitotic spindle formation, M Phase, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Mitotic Prometaphase, Mitotic Spindle Checkpoint, RHO GTPase Effectors, RHO GTPase cycle, RHO GTPases Activate Formins, RND2 GTPase cycle, Resolution of Sister Chromatid Cohesion, Separation of Sister Chromatids, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: O35685
Entrez ID: 18221
|
Does Knockout of Hook1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Hook1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hook1 (hook microtubule tethering protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, cell differentiation, cytoplasmic microtubule organization, cytoskeleton-dependent intracellular transport, early endosome to late endosome transport, endomembrane system organization, endosome organization, endosome to lysosome transport, lysosome organization, manchette assembly, protein localization to perinuclear region of cytoplasm, protein transport, spermatid development, spermatogenesis; MF: actin binding, dynein light intermediate chain binding, identical protein binding, microtubule binding, protein binding, protein homodimerization activity; CC: FHF complex, HOPS complex, centrosome, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton
Pathways:
UniProt: Q8BIL5
Entrez ID: 77963
|
Does Knockout of Ndufb10 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ndufb10
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ndufb10 (NADH:ubiquinone oxidoreductase subunit B10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9DCS9
Entrez ID: 68342
|
Does Knockout of Thap1 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Thap1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Thap1 (THAP domain containing, apoptosis associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, endothelial cell proliferation, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of mitotic cell cycle, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, metal ion binding, protein homodimerization activity, sequence-specific DNA binding, zinc ion binding; CC: PML body, fibrillar center, nucleoplasm, nucleus
Pathways:
UniProt: Q8CHW1
Entrez ID: 73754
|
Does Knockout of Nr1h2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 1
| 2,171
|
Knockout
|
Nr1h2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Nr1h2 (nuclear receptor subfamily 1, group H, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, cholesterol homeostasis, hormone-mediated signaling pathway, intracellular receptor signaling pathway, lipid homeostasis, lipid metabolic process, mRNA transcription by RNA polymerase II, negative regulation of DNA-templated transcription, negative regulation of cholesterol storage, negative regulation of cold-induced thermogenesis, negative regulation of gene expression, negative regulation of inflammatory response, negative regulation of lipid transport, negative regulation of pinocytosis, negative regulation of proteolysis, negative regulation of response to endoplasmic reticulum stress, negative regulation of transcription by RNA polymerase II, phosphatidylcholine acyl-chain remodeling, positive regulation of DNA-templated transcription, positive regulation of cholesterol efflux, positive regulation of cholesterol transport, positive regulation of fatty acid biosynthetic process, positive regulation of gene expression, positive regulation of high-density lipoprotein particle assembly, positive regulation of lipid storage, positive regulation of miRNA transcription, positive regulation of pancreatic juice secretion, positive regulation of secretion of lysosomal enzymes, positive regulation of transcription by RNA polymerase II, positive regulation of triglyceride biosynthetic process, regulation of DNA-templated transcription, regulation of lipid storage, regulation of pancreatic juice secretion, regulation of secretion of lysosomal enzymes, regulation of transcription by RNA polymerase II, response to nutrient levels, retinoic acid receptor signaling pathway; MF: ATPase binding, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, apolipoprotein A-I receptor binding, chromatin DNA binding, metal ion binding, nuclear receptor activity, nuclear retinoid X receptor binding, protein binding, sequence-specific DNA binding, zinc ion binding; CC: RNA polymerase II transcription regulator complex, cytoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Insulin resistance - Mus musculus (mouse), Metabolism of proteins, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis, NR1H2 and NR1H3-mediated signaling, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux, Nuclear Receptor transcription pathway, Plasma lipoprotein assembly, remodeling, and clearance, Plasma lipoprotein clearance, Post-translational protein modification, RNA Polymerase II Transcription, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of intracellular receptors, Signal Transduction, Signaling by Nuclear Receptors, Transport of small molecules, VLDLR internalisation and degradation
UniProt: Q60644
Entrez ID: 22260
|
Does Knockout of Jpt1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Jpt1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Jpt1 (Jupiter microtubule associated homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm, cytosol, intercellular bridge, microtubule cytoskeleton, nucleoplasm, nucleus
Pathways:
UniProt: P97825
Entrez ID: 15374
|
Does Knockout of Ctu2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Ctu2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ctu2 (cytosolic thiouridylase subunit 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein urmylation, tRNA processing, tRNA thio-modification, tRNA wobble position uridine thiolation, tRNA wobble uridine modification; MF: nucleotidyltransferase activity, sulfurtransferase activity, tRNA binding; CC: cytoplasm, cytosol, protein-containing complex
Pathways: Sulfur relay system - Mus musculus (mouse)
UniProt: Q3U308
Entrez ID: 66965
|
Does Knockout of Ckap2l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Ckap2l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Ckap2l (cytoskeleton associated protein 2-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, cilium, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton, mitotic spindle, spindle pole
Pathways:
UniProt: Q7TS74
Entrez ID: 70466
|
Does Knockout of Dusp6 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Dusp6
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Dusp6 (dual specificity phosphatase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, negative regulation of ERK1 and ERK2 cascade, negative regulation of MAPK cascade, positive regulation of apoptotic process, regulation of heart growth, response to growth factor, response to nitrosative stress, response to xenobiotic stimulus, signal transduction; MF: MAP kinase tyrosine phosphatase activity, MAP kinase tyrosine/serine/threonine phosphatase activity, hydrolase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, protein tyrosine/threonine phosphatase activity; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Cytokine Signaling in Immune system, ERK/MAPK targets, ERKs are inactivated, Immune System, Innate Immune System, Interleukin-17 signaling, MAP kinase activation, MAPK family signaling cascades, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, MAPK1/MAPK3 signaling, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, Negative regulation of MAPK pathway, Nuclear Events (kinase and transcription factor activation), RAF-independent MAPK1/3 activation, RAF/MAP kinase cascade, Signal Transduction, Signaling by Interleukins, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Receptor Tyrosine Kinases, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q9DBB1
Entrez ID: 67603
|
Does Knockout of Ccnk in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,290
|
Knockout
|
Ccnk
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccnk (cyclin K)
Type: protein-coding
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity; protein kinase binding activity; and protein serine/threonine kinase activity. Acts upstream of or within in utero embryonic development and negative regulation of stem cell differentiation. Predicted to be located in nucleoplasm. Predicted to be part of cyclin K-CDK12 complex; cyclin K-CDK13 complex; and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; olfactory epithelium; and retina nuclear layer. Orthologous to human CCNK (cyclin K). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, cell division, host-mediated suppression of viral genome replication, in utero embryonic development, negative regulation of stem cell differentiation, positive regulation of DNA-templated transcription, elongation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation by RNA polymerase II, regulation of cell cycle, regulation of signal transduction, regulation of transcription by RNA polymerase II; MF: RNA polymerase II CTD heptapeptide repeat kinase activity, cyclin-dependent protein serine/threonine kinase activator activity, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, protein kinase binding; CC: cyclin K-CDK12 complex, cyclin K-CDK13 complex, cyclin/CDK positive transcription elongation factor complex, nucleoplasm, nucleus
Pathways:
UniProt: Q3U3M5
Entrez ID: 12454
|
Does Knockout of Sin3b in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Sin3b
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Sin3b (transcriptional regulator, SIN3B (yeast))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle tissue development, negative regulation of DNA-templated transcription, negative regulation of cell cycle, negative regulation of cell migration, negative regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of cell cycle, skeletal muscle tissue development; MF: chromatin binding, protein binding, transcription corepressor activity; CC: Sin3-type complex, X chromosome, XY body, Y chromosome, autosome, chromatin, cytoplasm, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Gene expression (Transcription), Generic Transcription Pathway, Metabolism, Metabolism of lipids, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of lipid metabolism by PPARalpha, Transcriptional regulation by RUNX1
UniProt: Q62141
Entrez ID: 20467
|
Does Knockout of Mrgprh in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Mrgprh
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mrgprh (MAS-related GPR, member H)
Type: protein-coding
Summary: Predicted to enable angiotensin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, angiotensin-activated signaling pathway, signal transduction; MF: G protein-coupled receptor activity, angiotensin receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q99MT8
Entrez ID: 80978
|
Does Knockout of Cypt2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Cypt2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Cypt2 (cysteine-rich perinuclear theca 2)
Type: protein-coding
Summary: cysteine-rich perinuclear theca 2
Gene Ontology:
Pathways:
UniProt: Q8CH23, Q6P924, A0A9L6KE70
Entrez ID: 245566
|
Does Knockout of Ndufa6 in Embryonic Fibroblast Cell Line causally result in protein/peptide accumulation?
| 0
| 2,474
|
Knockout
|
Ndufa6
|
protein/peptide accumulation
|
Embryonic Fibroblast Cell Line
|
Gene: Ndufa6 (NADH:ubiquinone oxidoreductase subunit A6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial respiratory chain complex I assembly, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q9CQZ5
Entrez ID: 67130
|
Does Knockout of Gnb1l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Gnb1l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gnb1l (guanine nucleotide binding protein (G protein), beta polypeptide 1-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage checkpoint signaling, DNA damage response, social behavior; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9EQ15
Entrez ID: 13972
|
Does Knockout of Cnnm3 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Cnnm3
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Cnnm3 (cyclin M3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: magnesium ion homeostasis, monoatomic ion transport, transmembrane transport; CC: membrane, plasma membrane
Pathways:
UniProt: Q32NY4
Entrez ID: 94218
|
Does Knockout of Smc6 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 1
| 1,265
|
Knockout
|
Smc6
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Smc6 (structural maintenance of chromosomes 6)
Type: protein-coding
Summary: Predicted to enable DNA binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including DNA recombination; cellular senescence; and negative regulation by host of viral genome replication. Located in chromosome; mitotic spindle pole; and nucleus. Part of Smc5-Smc6 complex. Is expressed in central nervous system; embryo; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human SMC6 (structural maintenance of chromosomes 6). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, cellular senescence, double-strand break repair, double-strand break repair via homologous recombination, host-mediated suppression of viral genome replication, positive regulation of chromosome segregation, telomere maintenance via recombination; MF: ATP binding, ATP hydrolysis activity, DNA secondary structure binding, damaged DNA binding, nucleotide binding, single-stranded DNA binding, ubiquitin protein ligase binding; CC: PML body, Smc5-Smc6 complex, chromosomal region, chromosome, chromosome, centromeric region, chromosome, telomeric region, interchromatin granule, mitotic spindle pole, nuclear speck, nucleoplasm, nucleus, sex chromosome, site of double-strand break
Pathways: Metabolism of proteins, Post-translational protein modification, SUMO E3 ligases SUMOylate target proteins, SUMOylation, SUMOylation of DNA damage response and repair proteins
UniProt: Q924W5
Entrez ID: 67241
|
Does Knockout of E130308A19Rik in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
E130308A19Rik
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: E130308A19Rik (RIKEN cDNA E130308A19 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8C4P0
Entrez ID: 230259
|
Does Knockout of Tmem151a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Tmem151a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmem151a (transmembrane protein 151A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: T-tubule, axon, cell projection, cellular_component, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q6GQT5
Entrez ID: 381199
|
Does Knockout of Vmn1r197 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Vmn1r197
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r197 (vomeronasal 1 receptor 197)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R265
Entrez ID: 171278
|
Does Knockout of Gtf2h2 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,541
|
Knockout
|
Gtf2h2
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Gtf2h2 (general transcription factor II H, polypeptide 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA-templated transcription, nucleotide-excision repair, regulation of transcription by RNA polymerase II, transcription by RNA polymerase II; MF: RNA polymerase II general transcription initiation factor activity, metal ion binding, zinc ion binding; CC: core TFIIH complex portion of holo TFIIH complex, nuclear speck, nucleus, transcription factor TFIID complex, transcription factor TFIIH core complex, transcription factor TFIIH holo complex
Pathways: Basal transcription factors - Mus musculus (mouse), DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Formation of Incision Complex in GG-NER, Formation of RNA Pol II elongation complex , Formation of TC-NER Pre-Incision Complex, Formation of the Early Elongation Complex, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), Metabolism of RNA, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), RNA Pol II CTD phosphorylation and interaction with CE, RNA Polymerase I Promoter Clearance, RNA Polymerase I Promoter Escape, RNA Polymerase I Transcription, RNA Polymerase I Transcription Initiation, RNA Polymerase I Transcription Termination, RNA Polymerase II Pre-transcription Events, RNA Polymerase II Promoter Escape, RNA Polymerase II Transcription, RNA Polymerase II Transcription Elongation, RNA Polymerase II Transcription Initiation, RNA Polymerase II Transcription Initiation And Promoter Clearance, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening, TP53 Regulates Transcription of DNA Repair Genes, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Viral carcinogenesis - Mus musculus (mouse), mRNA Capping
UniProt: Q9JIB4
Entrez ID: 23894
|
Does Knockout of Tmprss11c in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Tmprss11c
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tmprss11c (transmembrane protease, serine 11c)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis, self proteolysis; MF: hydrolase activity, peptidase activity, serine-type endopeptidase activity, serine-type peptidase activity; CC: cell projection, dendrite, extracellular region, membrane, perikaryon, plasma membrane
Pathways:
UniProt: Q1JRP2
Entrez ID: 435845
|
Does Knockout of Tas2r119 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Tas2r119
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Tas2r119 (taste receptor, type 2, member 119)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, detection of chemical stimulus involved in sensory perception of bitter taste, detection of chemical stimulus involved in sensory perception of taste, sensory perception of taste, signal transduction; MF: G protein-coupled receptor activity, bitter taste receptor activity, taste receptor activity; CC: membrane
Pathways: Class C/3 (Metabotropic glutamate/pheromone receptors), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Sensory Perception, Sensory perception of sweet, bitter, and umami (glutamate) taste, Sensory perception of taste, Signal Transduction, Signaling by GPCR, Taste transduction - Mus musculus (mouse)
UniProt: Q9JKT2
Entrez ID: 57254
|
Does Knockout of Exoc5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Exoc5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Exoc5 (exocyst complex component 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane transport, epithelial cell apoptotic process, establishment of planar polarity, exocytosis, homeostasis of number of cells within a tissue, membrane fission, mitotic cytokinesis, morphogenesis of a polarized epithelium, non-motile cilium assembly, protein localization to plasma membrane, protein transport, vesicle docking involved in exocytosis, vesicle tethering involved in exocytosis; MF: protein binding, small GTPase binding; CC: cytoplasm, cytosol, exocyst, midbody
Pathways: Cargo trafficking to the periciliary membrane, Cilium Assembly, Insulin processing, Metabolism of proteins, Organelle biogenesis and maintenance, Peptide hormone metabolism, Salmonella infection - Mus musculus (mouse), VxPx cargo-targeting to cilium
UniProt: Q3TPX4
Entrez ID: 105504
|
Does Knockout of Mapk9 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Mapk9
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Mapk9 (mitogen-activated protein kinase 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, cellular response to UV, cellular response to reactive oxygen species, extrinsic apoptotic signaling pathway, inflammatory response to wounding, mRNA destabilization, modulation of chemical synaptic transmission, neuron projection development, positive regulation of DNA-templated transcription, positive regulation of apoptotic process, positive regulation of apoptotic signaling pathway, positive regulation of cell differentiation, positive regulation of chemokine production, positive regulation of cytokine production involved in inflammatory response, positive regulation of gene expression, positive regulation of macrophage derived foam cell differentiation, positive regulation of podosome assembly, positive regulation of prostaglandin biosynthetic process, positive regulation of prostaglandin secretion, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein ubiquitination, protein localization to tricellular tight junction, protein phosphorylation, regulation of JNK cascade, regulation of circadian rhythm, regulation of mRNA stability, regulation of protein ubiquitination, release of cytochrome c from mitochondria, response to cadmium ion, rhythmic process; MF: ATP binding, JUN kinase activity, MAP kinase activity, kinase activity, mitogen-activated protein kinase kinase kinase binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, protein serine/threonine/tyrosine kinase activity, transferase activity; CC: Schaffer collateral - CA1 synapse, cytoplasm, cytosol, mitochondrion, nuclear speck, nucleus, perikaryon, plasma membrane
Pathways: AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), Activation of the AP-1 family of transcription factors, Adipocytokine signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Apoptosis - multiple species - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Colorectal cancer - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, Diabetic cardiomyopathy - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), FCERI mediated MAPK activation, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), Hepatitis B - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Innate Immune System, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interleukin-17 signaling, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAP kinase activation, MAPK signaling pathway - Mus musculus (mouse), MAPK targets/ Nuclear events mediated by MAP kinases, Measles - Mus musculus (mouse), Mitophagy - animal - Mus musculus (mouse), MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Oxidative Stress Induced Senescence, Pancreatic cancer - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Relaxin signaling pathway - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Signaling by Interleukins, Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), T cell receptor signaling pathway - Mus musculus (mouse), TNF signaling pathway - Mus musculus (mouse), TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Th1 and Th2 cell differentiation - Mus musculus (mouse), Th17 cell differentiation - Mus musculus (mouse), Tight junction - Mus musculus (mouse), Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Toll-like receptor signaling pathway - Mus musculus (mouse), Toxoplasmosis - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), Wnt signaling pathway - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q9WTU6
Entrez ID: 26420
|
Does Knockout of Ric3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Ric3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ric3 (RIC3 acetylcholine receptor chaperone)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of cytosolic calcium ion concentration, positive regulation of protein localization to cell surface, protein folding, protein localization to cell surface, protein-containing complex assembly, synaptic transmission, cholinergic; MF: acetylcholine receptor binding, protein folding chaperone; CC: endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, neuron projection, neuronal cell body, synapse
Pathways:
UniProt: Q8BPM6
Entrez ID: 320360
|
Does Knockout of C1qtnf5 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
C1qtnf5
|
cell cycle progression
|
breast epithelium
|
Gene: C1qtnf5 (C1q and tumor necrosis factor related protein 5)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the C1q/tumor necrosis factor superfamily. This family member is a secretory protein that functions in eye development. Mutations in this gene are thought to underlie the pathophysiology of late-onset retinal degeneration (L-ORD) and early-onset long anterior zonules (LAZ). Bicistronic transcripts composed of the coding sequences for this gene (C1qtnf5) and the membrane-type frizzled-related protein gene (Mfrp) have been identified, and the resulting products can interact with each other. Co-transcription of C1qtnf5 and Mfrp has been observed in both human and mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].
Gene Ontology: BP: inner ear development, protein secretion; MF: identical protein binding, protein binding; CC: apical plasma membrane, bicellular tight junction, cell projection, collagen trimer, extracellular region, extracellular space, lateral plasma membrane, membrane, plasma membrane, protein-containing complex, transport vesicle
Pathways:
UniProt: Q8K480, Q8K479
Entrez ID: 235312
|
Does Knockout of Lgi3 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,681
|
Knockout
|
Lgi3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Lgi3 (leucine-rich repeat LGI family, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: exocytosis, regulation of exocytosis; CC: axon, cell projection, cytoplasmic vesicle, extracellular region, extracellular space, juxtaparanode region of axon, neuron projection, synapse, synaptic vesicle
Pathways: Developmental Biology, LGI-ADAM interactions
UniProt: Q8K406
Entrez ID: 213469
|
Does Knockout of Phkb in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Phkb
|
cell proliferation
|
Regulatory T cell
|
Gene: Phkb (phosphorylase kinase beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, glucose homeostasis, glycogen metabolic process, positive regulation of glycogen catabolic process; CC: membrane, phosphorylase kinase complex, plasma membrane
Pathways: Calcium signaling pathway - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), Glycogen breakdown (glycogenolysis), Glycogen metabolism, Insulin signaling pathway - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q7TSH2
Entrez ID: 102093
|
Does Knockout of Arl6ip4 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Arl6ip4
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Arl6ip4 (ADP-ribosylation factor-like 6 interacting protein 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing; CC: nuclear speck, nucleolus, nucleus
Pathways:
UniProt: Q9JM93
Entrez ID: 65105
|
Does Knockout of Gm16451 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Gm16451
|
phagocytosis
|
macrophage
|
Gene: Gm16451 (predicted pseudogene 16451)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: D3YZG3
Entrez ID: 100043033
|
Does Knockout of Skint10 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Skint10
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Skint10 (selection and upkeep of intraepithelial T cells 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell receptor signaling pathway, regulation of cytokine production; CC: external side of plasma membrane, membrane
Pathways:
UniProt: A7TZG1
Entrez ID: 230613
|
Does Knockout of Mybl1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mybl1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mybl1 (myeloblastosis oncogene-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, male meiosis I, mitotic cell cycle, positive regulation of piRNA transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, spermatogenesis; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, promoter-specific chromatin binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: P51960
Entrez ID: 17864
|
Does Knockout of Spen in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 1,130
|
Knockout
|
Spen
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Spen (spen family transcription repressor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Notch signaling pathway, negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of neurogenesis, random inactivation of X chromosome, regulation of transcription by RNA polymerase II, regulatory ncRNA-mediated heterochromatin formation; MF: DNA-binding transcription factor activity, RNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, mRNA binding, nucleic acid binding, protein binding, single-stranded DNA binding, transcription corepressor activity; CC: nucleoplasm, nucleus, transcription repressor complex
Pathways: RHO GTPase cycle, RHOBTB GTPase Cycle, RHOBTB1 GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q62504
Entrez ID: 56381
|
Does Knockout of Vmn2r116 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Vmn2r116
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Vmn2r116 (vomeronasal 2, receptor 116)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, positive regulation of female receptivity, response to pheromone, signal transduction; MF: G protein-coupled receptor activity, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: E9Q6I0
Entrez ID: 619697
|
Does Knockout of Eif2s2 in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Eif2s2
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Eif2s2 (eukaryotic translation initiation factor 2 subunit 2 beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translational initiation, formation of translation preinitiation complex, in utero embryonic development, male germ cell proliferation, male gonad development, translation, translational initiation; MF: mRNA binding, metal ion binding, protein binding, translation initiation factor activity, translation initiation factor binding, zinc ion binding; CC: cytoplasm, cytosol, eukaryotic translation initiation factor 2 complex, synapse
Pathways: ABC-family proteins mediated transport, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Cellular response to mitochondrial stress, Cellular responses to stimuli, Cellular responses to stress, Eukaryotic Translation Initiation, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Metabolism of proteins, PERK regulates gene expression, Recycling of eIF2:GDP, Ribosomal scanning and start codon recognition, Translation, Translation initiation complex formation, Transport of small molecules, Unfolded Protein Response (UPR)
UniProt: Q99L45
Entrez ID: 67204
|
Does Knockout of Rps4x in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Rps4x
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Rps4x (ribosomal protein S4, X-linked)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoplasmic translation, positive regulation of cell population proliferation, positive regulation of translation, ribosomal small subunit biogenesis, translation; MF: RNA binding, rRNA binding, structural constituent of ribosome; CC: cytoplasm, cytoplasmic ribonucleoprotein granule, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P62702
Entrez ID: 20102
|
Does Knockout of Wdr20 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Wdr20
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Wdr20 (WD repeat domain 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: deubiquitinase activator activity, molecular_function; CC: cellular_component, cytoplasm, nucleus
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q9D721, Q3UWE6, A0A0A6YXV5, A0A0A6YX87
Entrez ID: 69641
|
Does Knockout of Prdm16 in Immortal mouse chromaffin cells causally result in cell viability?
| 1
| 2,469
|
Knockout
|
Prdm16
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Prdm16 (PR domain containing 16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: beige fat cell differentiation, brown fat cell differentiation, cell differentiation, chromatin remodeling, heterochromatin organization, maintenance of cell number, methylation, negative regulation of DNA-templated transcription, negative regulation of granulocyte differentiation, negative regulation of muscle cell differentiation, negative regulation of transcription by RNA polymerase II, negative regulation of transforming growth factor beta receptor signaling pathway, negative regulation of white fat cell differentiation, neurogenesis, positive regulation of DNA-templated transcription, positive regulation of brown fat cell differentiation, positive regulation of cold-induced thermogenesis, positive regulation of transcription by RNA polymerase II, protein localization to chromatin, regulation of cellular respiration, regulation of transcription by RNA polymerase II, regulatory T cell differentiation, roof of mouth development, somatic stem cell population maintenance, stem cell population maintenance, tolerance induction in gut-associated lymphoid tissue, tongue development, white fat cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, SMAD binding, chromatin-protein adaptor activity, histone H3K9 methyltransferase activity, histone H3K9 monomethyltransferase activity, histone H3K9me2 methyltransferase activity, metal ion binding, methyltransferase activity, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding, transcription coactivator activity, transcription coregulator activity, transcription corepressor activity, transferase activity, zinc ion binding; CC: aggresome, chromatin, cytoplasm, cytosol, nucleoplasm, nucleus, transcription regulator complex, transcription repressor complex
Pathways: Chromatin modifying enzymes, Chromatin organization, Lysine degradation - Mus musculus (mouse), PKMTs methylate histone lysines, Thermogenesis - Mus musculus (mouse)
UniProt: A2A935
Entrez ID: 70673
|
Does Knockout of Sv2b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Sv2b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Sv2b (synaptic vesicle glycoprotein 2b)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chemical synaptic transmission, neurotransmitter transport, regulation of presynaptic cytosolic calcium ion concentration, regulation of synaptic vesicle exocytosis, transmembrane transport; CC: acrosomal vesicle, cytoplasmic vesicle, glutamatergic synapse, membrane, synapse, synaptic vesicle, synaptic vesicle membrane
Pathways: ECM-receptor interaction - Mus musculus (mouse)
UniProt: Q8BG39
Entrez ID: 64176
|
Does Knockout of Babam1 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 1
| 1,133
|
Knockout
|
Babam1
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Babam1 (BRISC and BRCA1 A complex member 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA repair-dependent chromatin remodeling, cell division, chromatin organization, double-strand break repair, hematopoietic stem cell proliferation, mitotic G2 DNA damage checkpoint signaling, mitotic G2/M transition checkpoint, positive regulation of DNA repair, regulation of DNA repair, response to ionizing radiation; MF: identical protein binding, molecular_function; CC: BRCA1-A complex, BRISC complex, cytoplasm, cytosol, nuclear body, nucleoplasm, nucleus
Pathways: Cell Cycle, Cell Cycle Checkpoints, DNA Double Strand Break Response, DNA Double-Strand Break Repair, DNA Repair, Deubiquitination, G2/M Checkpoints, G2/M DNA damage checkpoint, HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), Homologous recombination - Mus musculus (mouse), Homology Directed Repair, Metabolism of proteins, Metalloprotease DUBs, Nonhomologous End-Joining (NHEJ), Post-translational protein modification, Processing of DNA double-strand break ends, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
UniProt: Q3UI43
Entrez ID: 68251
|
Does Knockout of Kat2a in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,275
|
Knockout
|
Kat2a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Kat2a (K(lysine) acetyltransferase 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to nerve growth factor stimulus, cellular response to tumor necrosis factor, chromatin remodeling, fibroblast proliferation, gluconeogenesis, heart development, in utero embryonic development, intracellular distribution of mitochondria, limb development, long-term memory, metencephalon development, midbrain development, multicellular organism growth, negative regulation of centriole replication, negative regulation of gluconeogenesis, negative regulation of transcription by RNA polymerase II, nervous system development, neural tube closure, peptidyl-lysine glutarylation, positive regulation of DNA-templated transcription, positive regulation of cardiac muscle cell differentiation, positive regulation of cell projection organization, positive regulation of cytokine production, positive regulation of gluconeogenesis, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of DNA-templated transcription, regulation of RNA splicing, regulation of T cell activation, regulation of bone development, regulation of cartilage development, regulation of cell cycle, regulation of cell division, regulation of embryonic development, regulation of gene expression, regulation of protein stability, regulation of regulatory T cell differentiation, regulation of stem cell population maintenance, regulation of synaptic plasticity, regulation of transcription by RNA polymerase II, response to nutrient levels, somitogenesis, telencephalon development; MF: DNA-binding transcription factor binding, N-acetyltransferase activity, acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, chromatin binding, histone H3 acetyltransferase activity, histone H3K18 acetyltransferase activity, histone H3K9 acetyltransferase activity, histone H4K12 acetyltransferase activity, histone acetyltransferase activity, histone deacetylase binding, histone glutaryltransferase activity, histone succinyltransferase activity, peptide glutaryltransferase activity, protein binding, protein phosphatase binding, protein-lysine-acetyltransferase activity, transcription coactivator activity, transferase activity; CC: ATAC complex, SAGA complex, centrosome, chromatin, chromosome, cytoplasm, cytoskeleton, histone acetyltransferase complex, mitotic spindle, nucleoplasm, nucleus, oxoglutarate dehydrogenase complex, transcription factor TFTC complex
Pathways: B-WICH complex positively regulates rRNA expression, Deubiquitination, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of gene expression, Formation of WDR5-containing histone-modifying complexes, Gene expression (Transcription), Generic Transcription Pathway, Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Metabolism of proteins, NOTCH1 Intracellular Domain Regulates Transcription, Notch signaling pathway - Mus musculus (mouse), Notch-HLH transcription pathway, Positive epigenetic regulation of rRNA expression, Post-translational protein modification, RNA Polymerase II Transcription, RUNX3 regulates NOTCH signaling, Signal Transduction, Signaling by NOTCH, Signaling by NOTCH1, Thyroid hormone signaling pathway - Mus musculus (mouse), Transcriptional regulation by RUNX3, Ub-specific processing proteases, Viral carcinogenesis - Mus musculus (mouse)
UniProt: Q9JHD2
Entrez ID: 14534
|
Does Knockout of Ybx2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Ybx2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ybx2 (Y box protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA stabilization, negative regulation of RNA metabolic process, negative regulation of macromolecule biosynthetic process, negative regulation of translation, oogenesis, positive regulation of cold-induced thermogenesis, regulation of gene expression, spermatid development; MF: DNA binding, RNA binding, chromatin binding, lipid binding, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding, ribonucleoprotein complex binding, translation regulator activity; CC: cytoplasm, nucleus, ribonucleoprotein complex
Pathways:
UniProt: Q497N3, B2RUF0, A0A0A0MQD2, Q3TTC8, J3QNB9
Entrez ID: 53422
|
Does Knockout of Cebpz in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Cebpz
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cebpz (CCAAT/enhancer binding protein zeta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: CCAAT-binding factor complex, nucleoplasm, nucleus
Pathways:
UniProt: P53569
Entrez ID: 12607
|
Does Knockout of Atad2b in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Atad2b
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Atad2b (ATPase family, AAA domain containing 2B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nucleosome assembly, nucleosome disassembly, transcription initiation-coupled chromatin remodeling; MF: ATP binding, ATP hydrolysis activity, chromatin binding, histone binding, histone reader activity, nucleotide binding; CC: nucleoplasm, nucleus
Pathways:
UniProt:
Entrez ID: 320817
|
Does Knockout of Zfp593 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,684
|
Knockout
|
Zfp593
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zfp593 (zinc finger protein 593)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of transcription by RNA polymerase II, ribosome biogenesis; MF: DNA binding, metal ion binding, nucleic acid binding, preribosome binding, ribonucleoprotein complex binding, zinc ion binding; CC: cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q9DB42
Entrez ID: 68040
|
Does Knockout of Gnpat in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Gnpat
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gnpat (glyceronephosphate O-acyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cerebellum morphogenesis, ether lipid biosynthetic process, glycerophospholipid metabolic process, lipid metabolic process, membrane organization, myelination, paranodal junction assembly, synapse assembly; MF: O-acyltransferase activity, acyltransferase activity, catalytic activity, glycerone-phosphate O-acyltransferase activity, protein binding, transferase activity; CC: cell junction, membrane, peroxisomal matrix, peroxisomal membrane, peroxisome
Pathways: Glycerophospholipid biosynthesis, Glycerophospholipid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Peroxisomal protein import, Peroxisome - Mus musculus (mouse), Phospholipid metabolism, Plasmalogen biosynthesis, Protein localization, Synthesis of PA, Wax and plasmalogen biosynthesis
UniProt: P98192
Entrez ID: 14712
|
Does Knockout of Taar7f in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Taar7f
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Taar7f (trace amine-associated receptor 7F)
Type: protein-coding
Summary: Enables trace-amine receptor activity. Involved in sensory perception of chemical stimulus. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TAAR7P (trace amine associated receptor 7, pseudogene). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled amine receptor activity, G protein-coupled receptor activity, trace-amine receptor activity; CC: membrane, plasma membrane
Pathways: Neuroactive ligand-receptor interaction - Mus musculus (mouse)
UniProt: Q5QD08
Entrez ID: 435207
|
Does Knockout of Hic2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Hic2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hic2 (hypermethylated in cancer 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus, plasma membrane
Pathways:
UniProt: Q9JLZ6
Entrez ID: 58180
|
Does Knockout of Defa24 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Defa24
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Defa24 (defensin, alpha, 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antibacterial humoral response, antimicrobial humoral immune response mediated by antimicrobial peptide, defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, disruption of plasma membrane integrity in another organism, innate immune response, killing by host of symbiont cells, killing of cells of another organism, positive regulation of interleukin-8 production, positive regulation of membrane permeability, protein homotetramerization; MF: pore-forming activity, protein homodimerization activity; CC: extracellular region, extracellular space, midbody, secretory granule
Pathways: Alpha-defensins, Antimicrobial peptides, Defensins, Immune System, Innate Immune System, NOD-like receptor signaling pathway - Mus musculus (mouse), Neutrophil degranulation, Staphylococcus aureus infection - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q5G865
Entrez ID: 503491
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.