prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Cyp3a13 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Cyp3a13
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cyp3a13 (cytochrome P450, family 3, subfamily a, polypeptide 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: oxidative demethylation, positive regulation of gene expression, steroid metabolic process, xenobiotic transport; MF: 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity, caffeine oxidase activity, enzyme binding, estrogen 16-alpha-hydroxylase activity, estrogen 2-hydroxylase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, retinoic acid 4-hydroxylase activity, steroid binding, steroid hydroxylase activity, testosterone 6-beta-hydroxylase activity, vitamin D 24-hydroxylase activity, vitamin D3 25-hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Aflatoxin activation and detoxification, Aspirin ADME, Atorvastatin ADME, Biological oxidations, Biosynthesis of DHA-derived SPMs, Biosynthesis of maresin-like SPMs, Biosynthesis of maresins, Biosynthesis of specialized proresolving mediators (SPMs), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Cytochrome P450 - arranged by substrate type, Drug ADME, Linoleic acid metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, Miscellaneous substrates, Phase I - Functionalization of compounds, Prednisone ADME, Retinol metabolism - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), Xenobiotics, bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: Q64464
Entrez ID: 13113
|
Does Knockout of Rhbdf1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Rhbdf1
|
cell cycle progression
|
breast epithelium
|
Gene: Rhbdf1 (rhomboid 5 homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, cell population proliferation, negative regulation of protein secretion, regulation of epidermal growth factor receptor signaling pathway, regulation of proteasomal protein catabolic process, regulation of protein secretion; CC: Golgi apparatus, Golgi membrane, cytoplasm, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q6PIX5
Entrez ID: 13650
|
Does Knockout of Slc2a9 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Slc2a9
|
response to bacteria
|
macrophage
|
Gene: Slc2a9 (solute carrier family 2 (facilitated glucose transporter), member 9)
Type: protein-coding
Summary: Enables D-glucose transmembrane transporter activity and urate transmembrane transporter activity. Involved in urate transport. Acts upstream of or within D-glucose transmembrane transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including early conceptus; heart; liver; metanephros; and thymus primordium. Used to study abdominal obesity-metabolic syndrome and hyperuricemia. Orthologous to human SLC2A9 (solute carrier family 2 member 9). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: D-glucose import, D-glucose transmembrane transport, dehydroascorbic acid transport, fructose transmembrane transport, transmembrane transport, urate metabolic process, urate transport; MF: D-glucose transmembrane transporter activity, fructose transmembrane transporter activity, transmembrane transporter activity, urate transmembrane transporter activity; CC: apical plasma membrane, basolateral plasma membrane, membrane, nuclear envelope, plasma membrane
Pathways: Cellular hexose transport, SLC-mediated transmembrane transport, Transport of small molecules
UniProt: Q3T9X0
Entrez ID: 117591
|
Does Knockout of Klk1b4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Klk1b4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Klk1b4 (kallikrein 1-related pepidase b4)
Type: protein-coding
Summary: This gene encodes the alpha subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016].
Gene Ontology: BP: positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, proteolysis, regulation of systemic arterial blood pressure, small GTPase-mediated signal transduction, zymogen activation; MF: endopeptidase activity, growth factor activity, metal ion binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: acrosomal vesicle, apical part of cell, extracellular space, nucleus, secretory granule
Pathways: Activation of Matrix Metalloproteinases, Calcium signaling pathway - Mus musculus (mouse), Cytokine-cytokine receptor interaction - Mus musculus (mouse), Degradation of the extracellular matrix, Extracellular matrix organization, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse)
UniProt: P00757
Entrez ID: 18048
|
Does Knockout of Lyst in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Lyst
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Lyst (lysosomal trafficking regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell mediated immunity, blood coagulation, defense response to bacterium, defense response to other organism, defense response to protozoan, defense response to virus, endosome to lysosome transport via multivesicular body sorting pathway, granulocyte chemotaxis, immune response, lymphocyte mediated immunity, lysosome organization, mast cell secretory granule organization, melanosome organization, microtubule-based process, natural killer cell mediated cytotoxicity, neutrophil mediated immunity, phagocytosis, phospholipid homeostasis, phospholipid metabolic process, pigment granule organization, pigmentation, positive regulation of natural killer cell activation, protein transport, response to xenobiotic stimulus, secretion of lysosomal enzymes; CC: cytoplasm, cytosol, microtubule cytoskeleton
Pathways:
UniProt: P97412
Entrez ID: 17101
|
Does Knockout of Slc25a44 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Slc25a44
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Slc25a44 (solute carrier family 25, member 44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, branched-chain amino acid catabolic process, branched-chain amino acid transport, regulation of cold-induced thermogenesis, transmembrane transport; MF: branched-chain amino acid transmembrane transporter activity; CC: membrane, mitochondrial inner membrane, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q8BGF9
Entrez ID: 229517
|
Does Knockout of Coq7 in Melanoma Cell Line causally result in response to chemicals?
| 0
| 2,490
|
Knockout
|
Coq7
|
response to chemicals
|
Melanoma Cell Line
|
Gene: Coq7 (demethyl-Q 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, determination of adult lifespan, in utero embryonic development, mitochondrial ATP synthesis coupled electron transport, mitochondrion organization, negative regulation of transcription by RNA polymerase II, neural tube formation, neurogenesis, positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulation of reactive oxygen species metabolic process, respiratory electron transport chain, response to oxidative stress, ubiquinone biosynthetic process; MF: 3-demethoxyubiquinol 3-hydroxylase activity, 3-demethoxyubiquinone 3-hydroxylase (NADH) activity, chromatin binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; CC: extrinsic component of mitochondrial inner membrane, membrane, mitochondrial inner membrane, mitochondrion, nucleus, ubiquinone biosynthesis complex
Pathways: Metabolism, Metabolism of cofactors, Metabolism of vitamins and cofactors, Ubiquinol biosynthesis, Ubiquinone and other terpenoid-quinone biosynthesis - Mus musculus (mouse)
UniProt: P97478
Entrez ID: 12850
|
Does Knockout of Fnta in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Fnta
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Fnta (farnesyltransferase, CAAX box, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: enzyme-linked receptor protein signaling pathway, negative regulation of apoptotic process, nuclear envelope organization, peptide pheromone maturation, positive regulation of Rac protein signal transduction, positive regulation of cell cycle, positive regulation of cell population proliferation, positive regulation of skeletal muscle acetylcholine-gated channel clustering, protein farnesylation, protein geranylgeranylation, protein maturation, regulation of microtubule-based movement; MF: CAAX-protein geranylgeranyltransferase activity, Rab geranylgeranyltransferase activity, acetyltransferase activator activity, alpha-tubulin binding, enzyme binding, heterocyclic compound binding, microtubule binding, molecular adaptor activity, peptide binding, prenyltransferase activity, protein farnesyltransferase activity, protein geranylgeranyltransferase activity, protein prenyltransferase activity, receptor tyrosine kinase binding, small molecule binding, transferase activity, zinc ion binding; CC: CAAX-protein geranylgeranyltransferase complex, cytoplasm, microtubule associated complex, protein farnesyltransferase complex
Pathways: Terpenoid backbone biosynthesis - Mus musculus (mouse)
UniProt: Q61239
Entrez ID: 14272
|
Does Knockout of Hnrnpd in Mouse kidney carcinoma cell causally result in cell proliferation?
| 1
| 1,289
|
Knockout
|
Hnrnpd
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hnrnpd (heterogeneous nuclear ribonucleoprotein D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, CRD-mediated mRNA stabilization, cellular response to amino acid stimulus, cellular response to estradiol stimulus, cellular response to nitric oxide, cellular response to putrescine, cerebellum development, circadian regulation of translation, hepatocyte dedifferentiation, liver development, negative regulation of gene expression, negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of cytoplasmic translation, positive regulation of gene expression, positive regulation of macromolecule biosynthetic process, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, positive regulation of transcription by RNA polymerase II, positive regulation of translation, regulation of circadian rhythm, regulation of gene expression, regulation of mRNA stability, response to calcium ion, response to electrical stimulus, response to estradiol, response to rapamycin, response to sodium phosphate, rhythmic process; MF: DNA binding, RNA binding, chromatin binding, histone deacetylase binding, mRNA 3'-UTR AU-rich region binding, mRNA binding, minor groove of adenine-thymine-rich DNA binding, nucleic acid binding, protein binding, telomeric DNA binding; CC: chromatin, cytoplasm, cytosol, glutamatergic synapse, mCRD-mediated mRNA stability complex, nucleoplasm, nucleus, postsynaptic density, ribonucleoprotein complex, synapse
Pathways: AUF1 (hnRNP D0) binds and destabilizes mRNA, Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, Regulation of mRNA stability by proteins that bind AU-rich elements, mRNA Splicing, mRNA Splicing - Major Pathway
UniProt: Q60668
Entrez ID: 11991
|
Does Knockout of Tmem8b in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Tmem8b
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tmem8b (transmembrane protein 8B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-matrix adhesion; CC: cell surface, cytoplasm, endoplasmic reticulum, membrane, mitochondrion, nucleus, plasma membrane
Pathways:
UniProt: B1AWJ5
Entrez ID: 242409
|
Does Knockout of Krt12 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Krt12
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Krt12 (keratin 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cornea development in camera-type eye, epithelial cell differentiation, epithelium development, intermediate filament organization, morphogenesis of an epithelium; MF: structural constituent of skin epidermis, structural molecule activity; CC: cytoskeleton, intermediate filament, keratin filament
Pathways: Estrogen signaling pathway - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Z4YJD9
Entrez ID: 268482
|
Does Knockout of 1810055G02Rik in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
1810055G02Rik
|
phagocytosis
|
macrophage
|
Gene: 1810055G02Rik (RIKEN cDNA 1810055G02 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, membrane, nucleoplasm, plasma membrane
Pathways:
UniProt: Q9D8N1
Entrez ID: 72056
|
Does Knockout of Mutyh in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,267
|
Knockout
|
Mutyh
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Mutyh (mutY DNA glycosylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, mismatch repair, negative regulation of necroptotic process, response to oxidative stress, response to stress; MF: 4 iron, 4 sulfur cluster binding, 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity, DNA N-glycosylase activity, DNA binding, MutSalpha complex binding, adenine/guanine mispair binding, catalytic activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, iron-sulfur cluster binding, metal ion binding, oxidized purine DNA binding, purine-specific mismatch base pair DNA N-glycosylase activity; CC: mitochondrion, nucleoplasm, nucleus
Pathways: Base Excision Repair, Base excision repair - Mus musculus (mouse), Base-Excision Repair, AP Site Formation, Cleavage of the damaged purine, DNA Repair, Depurination, Displacement of DNA glycosylase by APEX1, Resolution of Abasic Sites (AP sites)
UniProt: Q99P21
Entrez ID: 70603
|
Does Knockout of Kif12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Kif12
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Kif12 (kinesin family member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule-based movement, negative regulation of fatty acid biosynthetic process; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide binding; CC: cilium, cytoplasm, cytoskeleton, extracellular exosome, kinesin complex, microtubule, microtubule organizing center, organelle
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Factors involved in megakaryocyte development and platelet production, Golgi-to-ER retrograde transport, Hemostasis, Intra-Golgi and retrograde Golgi-to-ER traffic, Kinesins, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q9D2Z8
Entrez ID: 16552
|
Does Knockout of Lpar6 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Lpar6
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Lpar6 (lysophosphatidic acid receptor 6)
Type: protein-coding
Summary: Predicted to enable lysophosphatidic acid receptor activity. Acts upstream of or within blastocyst hatching. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Human ortholog(s) of this gene implicated in hypotrichosis 8. Orthologous to human LPAR6 (lysophosphatidic acid receptor 6). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: G protein-coupled receptor signaling pathway, blastocyst hatching, signal transduction; MF: G protein-coupled receptor activity, lysophosphatidic acid receptor activity; CC: membrane, plasma membrane
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nucleotide-like (purinergic) receptors, P2Y receptors, PI3K-Akt signaling pathway - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by GPCR
UniProt: Q8BMC0
Entrez ID: 67168
|
Does Knockout of Bcat1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Bcat1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Bcat1 (branched chain aminotransferase 1, cytosolic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-leucine biosynthetic process, L-valine biosynthetic process, amino acid biosynthetic process, branched-chain amino acid biosynthetic process, branched-chain amino acid catabolic process, branched-chain amino acid metabolic process, lipid metabolic process; MF: L-isoleucine-2-oxoglutarate transaminase activity, L-leucine-2-oxoglutarate transaminase activity, L-valine-2-oxoglutarate transaminase activity, branched-chain-amino-acid transaminase activity, catalytic activity, identical protein binding, transaminase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion
Pathways: Branched-chain amino acid catabolism, Cysteine and methionine metabolism - Mus musculus (mouse), Leucine Catabolism, Metabolism, Metabolism of amino acids and derivatives, Pantothenate and CoA biosynthesis - Mus musculus (mouse), Valine, leucine and isoleucine biosynthesis - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), isoleucine degradation, leucine degradation I, valine degradation, valine degradation I
UniProt: P24288
Entrez ID: 12035
|
Does Knockout of Tcp11l1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Tcp11l1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tcp11l1 (t-complex 11 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: microtubule
Pathways:
UniProt: Q8BTG3
Entrez ID: 320554
|
Does Knockout of Mir7670 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Mir7670
|
cell cycle progression
|
breast epithelium
|
Gene: Mir7670 (microRNA 7670)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102466843
|
Does Knockout of Gm4204 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Gm4204
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Gm4204 (nucleosome assembly protein 1-like 1 pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100043064
|
Does Knockout of Zcchc10 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Zcchc10
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zcchc10 (zinc finger, CCHC domain containing 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, nucleic acid binding, zinc ion binding
Pathways:
UniProt: Q9CX48
Entrez ID: 67966
|
Does Knockout of Tmem45a2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Tmem45a2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tmem45a2 (transmembrane protein 45A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8CEZ6, B7ZWJ5
Entrez ID: 69457
|
Does Knockout of Chmp4b in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Chmp4b
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Chmp4b (charged multivesicular body protein 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, membrane fission, midbody abscission, mitotic cytokinesis, mitotic metaphase chromosome alignment, multivesicular body assembly, multivesicular body sorting pathway, multivesicular body-lysosome fusion, nuclear membrane reassembly, nucleus organization, plasma membrane repair, protein transport, regulation of autophagy, regulation of mitotic spindle assembly, ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway, vacuolar transport, vesicle budding from membrane, vesicle fusion with vacuole, viral budding from plasma membrane, viral budding via host ESCRT complex; MF: identical protein binding, protein binding, protein homodimerization activity; CC: ESCRT III complex, amphisome membrane, autophagosome membrane, cytoplasm, cytoplasmic side of plasma membrane, cytosol, endosome, endosome membrane, glutamatergic synapse, kinetochore, kinetochore microtubule, late endosome membrane, lysosomal membrane, membrane, membrane coat, midbody, multivesicular body, multivesicular body membrane, nuclear envelope, nuclear pore, nucleus, plasma membrane, postsynaptic density, vesicle
Pathways: Autophagy, Cell Cycle, Cell Cycle, Mitotic, Endocytosis - Mus musculus (mouse), Endosomal Sorting Complex Required For Transport (ESCRT), M Phase, Macroautophagy, Membrane Trafficking, Mitotic Anaphase, Mitotic Metaphase and Anaphase, Necroptosis - Mus musculus (mouse), Nuclear Envelope (NE) Reassembly, Programmed Cell Death, Pyroptosis, Regulated Necrosis, Sealing of the nuclear envelope (NE) by ESCRT-III, Vesicle-mediated transport
UniProt: Q9D8B3
Entrez ID: 75608
|
Does Knockout of Ebp in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Ebp
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Ebp (EBP cholestenol delta-isomerase)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that localizes to the endoplasmic reticulum. This protein catalyses the conversion of delta8 to delta7 sterols, an important step in sterol biosynthesis. Mutations in this gene are responsible for the mouse tattered mutant phenotype. Tattered males are embryonic lethal, while heterozygous females have developmental defects. Deficiency of the related gene in human causes X-linked dominant chondrodysplasia punctata. [provided by RefSeq, May 2015].
Gene Ontology: BP: cholesterol biosynthetic process, cholesterol biosynthetic process via desmosterol, cholesterol biosynthetic process via lathosterol, cholesterol metabolic process, hemopoiesis, lipid metabolic process, ossification involved in bone maturation, steroid biosynthetic process, steroid metabolic process, sterol biosynthetic process, sterol metabolic process; MF: C-8 sterol isomerase activity, cholestenol delta-isomerase activity, cholesterol-5,6-oxide hydrolase activity, hydrolase activity, identical protein binding, intramolecular oxidoreductase activity, transposing C=C bonds, isomerase activity, steroid Delta-isomerase activity; CC: cytoplasmic vesicle, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, nuclear envelope, nuclear membrane, nucleus
Pathways: Cholesterol biosynthesis, Cholesterol biosynthesis via desmosterol, Cholesterol biosynthesis via lathosterol, Metabolism, Metabolism of lipids, Metabolism of steroids, Steroid biosynthesis - Mus musculus (mouse), cholesterol biosynthesis I, cholesterol biosynthesis II (via 24,25-dihydrolanosterol), cholesterol biosynthesis III (via desmosterol), superpathway of cholesterol biosynthesis
UniProt: P70245
Entrez ID: 13595
|
Does Knockout of Frat2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Frat2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Frat2 (frequently rearranged in advanced T cell lymphomas 2)
Type: protein-coding
Summary: Acts upstream of or within Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human FRAT2 (FRAT regulator of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, canonical Wnt signaling pathway, regulation of protein export from nucleus; CC: cytoplasm, nucleus
Pathways: Alzheimer disease - Mus musculus (mouse), Beta-catenin phosphorylation cascade, Breast cancer - Mus musculus (mouse), Degradation of beta-catenin by the destruction complex, Disassembly of the destruction complex and recruitment of AXIN to the membrane, Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q8K025
Entrez ID: 212398
|
Does Knockout of Mettl16 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Mettl16
|
phagocytosis
|
macrophage
|
Gene: Mettl16 (methyltransferase 16, N6-methyladenosine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, RNA modification, S-adenosylmethionine biosynthetic process, mRNA catabolic process, mRNA destabilization, mRNA processing, methylation, negative regulation of 3'-UTR-mediated mRNA stabilization, positive regulation of mRNA catabolic process, post-transcriptional regulation of gene expression, rRNA base methylation, regulation of mRNA splicing, via spliceosome, regulation of mRNA stability, snRNA (adenine-N6)-methylation; MF: RNA binding, RNA stem-loop binding, U6 snRNA (adenine-(43)-N(6))-methyltransferase activity, U6 snRNA 3'-end binding, mRNA m(6)A methyltransferase activity, methyltransferase activity, transferase activity; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9CQG2
Entrez ID: 67493
|
Does Knockout of Ryk in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Ryk
|
response to virus
|
Microglial Cell Line
|
Gene: Ryk (receptor-like tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, axon guidance, axonogenesis, cell surface receptor protein tyrosine kinase signaling pathway, chemorepulsion of axon, chemorepulsion of dopaminergic neuron axon, commissural neuron axon guidance, corpus callosum development, midbrain dopaminergic neuron differentiation, negative chemotaxis, negative regulation of axon extension involved in axon guidance, neuron differentiation, neuron projection development, positive regulation of MAPK cascade, positive regulation of cell proliferation in midbrain, positive regulation of neuron projection development, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, skeletal system morphogenesis; MF: ATP binding, Wnt receptor activity, Wnt-protein binding, frizzled binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, transmembrane signaling receptor activity; CC: cytoplasm, glutamatergic synapse, membrane, nucleus, plasma membrane, postsynaptic density membrane, presynaptic active zone membrane, receptor complex
Pathways: Axon guidance - Mus musculus (mouse), Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q01887
Entrez ID: 20187
|
Does Knockout of Flcn in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,268
|
Knockout
|
Flcn
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Flcn (folliculin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, TORC1 signaling, cell-cell junction assembly, cellular response to amino acid starvation, cellular response to nutrient levels, cellular response to starvation, energy homeostasis, hemopoiesis, in utero embryonic development, intracellular signal transduction, lysosome localization, lysosome organization, negative regulation of DNA-templated transcription, negative regulation of ERK1 and ERK2 cascade, negative regulation of Rho protein signal transduction, negative regulation of TOR signaling, negative regulation of brown fat cell differentiation, negative regulation of cell population proliferation, negative regulation of cell proliferation involved in kidney development, negative regulation of cold-induced thermogenesis, negative regulation of epithelial cell proliferation, negative regulation of glycolytic process, negative regulation of intracellular signal transduction, negative regulation of lysosome organization, negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, negative regulation of post-translational protein modification, negative regulation of protein localization to nucleus, negative regulation of transcription by RNA polymerase II, positive regulation of TOR signaling, positive regulation of TORC1 signaling, positive regulation of autophagy, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of transforming growth factor beta receptor signaling pathway, protein destabilization, regulation of Ras protein signal transduction, regulation of TOR signaling, regulation of pro-B cell differentiation; MF: GTPase activator activity, enzyme binding, enzyme inhibitor activity, protein binding, protein-containing complex binding; CC: FNIP-folliculin RagC/D GAP, cell projection, cell-cell contact zone, centrosome, cilium, cytoplasm, cytoskeleton, cytosol, lysosomal membrane, lysosome, membrane, midbody, mitotic spindle, nucleus, plasma membrane, spindle
Pathways: Amino acids regulate mTORC1, Cellular response to starvation, Cellular responses to stimuli, Cellular responses to stress, Renal cell carcinoma - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q8QZS3
Entrez ID: 216805
|
Does Knockout of Lyrm1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Lyrm1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Lyrm1 (LYR motif containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: midbody, mitochondrion, nucleoplasm
Pathways:
UniProt: Q9CQB7
Entrez ID: 73919
|
Does Knockout of Sobp in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Sobp
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sobp (sine oculis binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cochlea development, cognition, inner ear morphogenesis, locomotory behavior, sensory perception of sound; MF: SUMO polymer binding, metal ion binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: Q0P5V2
Entrez ID: 109205
|
Does Knockout of Rnpc3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Rnpc3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rnpc3 (RNA-binding region (RNP1, RRM) containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA splicing, via spliceosome; MF: RNA binding, U12 snRNA binding, nucleic acid binding, pre-mRNA intronic binding; CC: U12-type spliceosomal complex, nucleoplasm, nucleus
Pathways: Metabolism of RNA, Processing of Capped Intron-Containing Pre-mRNA, mRNA Splicing, mRNA Splicing - Minor Pathway
UniProt: Q3UZ01
Entrez ID: 67225
|
Does Knockout of Tars2 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Tars2
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Tars2 (threonyl-tRNA synthetase 2, mitochondrial (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aminoacyl-tRNA metabolism involved in translational fidelity, tRNA aminoacylation, tRNA aminoacylation for protein translation, threonyl-tRNA aminoacylation, translation; MF: ATP binding, aminoacyl-tRNA deacylase activity, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, protein homodimerization activity, threonine-tRNA ligase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q3UQ84
Entrez ID: 71807
|
Does Knockout of Gbp3 in Immortal mouse chromaffin cells causally result in cell viability?
| 0
| 2,469
|
Knockout
|
Gbp3
|
cell viability
|
Immortal mouse chromaffin cells
|
Gene: Gbp3 (guanylate binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, adhesion of symbiont to host, cellular response to interferon-beta, cellular response to lipopolysaccharide, cellular response to tumor necrosis factor, cellular response to type II interferon, cytolysis in another organism, defense response to Gram-positive bacterium, defense response to bacterium, defense response to protozoan, immune system process, innate immune response, positive regulation of pyroptotic inflammatory response, regulation of defense response; MF: GTP binding, GTPase activity, hydrolase activity, identical protein binding, nucleotide binding, protein homodimerization activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytoplasmic vesicle, cytosol, membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, symbiont-containing vacuole membrane
Pathways: NOD-like receptor signaling pathway - Mus musculus (mouse)
UniProt: Q61107
Entrez ID: 55932
|
Does Knockout of Neto2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 163
|
Knockout
|
Neto2
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Neto2 (neuropilin (NRP) and tolloid (TLL)-like 2)
Type: protein-coding
Summary: Enables ionotropic glutamate receptor binding activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in postsynaptic density. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in central nervous system and retina. Orthologous to human NETO2 (neuropilin and tolloid like 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; MF: ionotropic glutamate receptor binding; CC: glutamatergic synapse, membrane, plasma membrane, postsynaptic density, postsynaptic density membrane, synapse
Pathways:
UniProt: Q8BNJ6
Entrez ID: 74513
|
Does Knockout of Rps19bp1 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Rps19bp1
|
response to bacteria
|
renal medulla cell line
|
Gene: Rps19bp1 (ribosomal protein S19 binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, ribosomal small subunit biogenesis; MF: enzyme binding, protein binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: Q8C6B9
Entrez ID: 66538
|
Does Knockout of Fank1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Fank1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Fank1 (fibronectin type 3 and ankyrin repeat domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of apoptotic process, positive regulation of DNA-binding transcription factor activity, positive regulation of DNA-templated transcription, positive regulation of apoptotic process; CC: cell projection, chromatin, ciliary basal body, ciliary base, cilium, cytoplasm, cytoskeleton, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9DAM9
Entrez ID: 66930
|
Does Knockout of Upk3a in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Upk3a
|
cell cycle progression
|
breast epithelium
|
Gene: Upk3a (uroplakin 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell morphogenesis, epithelial cell differentiation, kidney development, potassium ion homeostasis, sodium ion homeostasis, urea transport, urinary bladder development, water transport; CC: apical plasma membrane, apical plasma membrane urothelial plaque, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Bladder cancer - Mus musculus (mouse)
UniProt: Q9JKX8
Entrez ID: 22270
|
Does Knockout of Defb48 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Defb48
|
phagocytosis
|
macrophage
|
Gene: Defb48 (defensin beta 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response, defense response to bacterium, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity; CC: extracellular region, extracellular space
Pathways: Antimicrobial peptides, Beta defensins, Defensins, Immune System, Innate Immune System
UniProt: Q3UW22
Entrez ID: 432867
|
Does Knockout of Pou2f2 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Pou2f2
|
phagocytosis
|
macrophage
|
Gene: Pou2f2 (POU domain, class 2, transcription factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell maturation, cellular response to virus, mature B cell differentiation, positive regulation of DNA-templated transcription, positive regulation of interleukin-6 production, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, spermidine transmembrane transport, spermidine transport; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein domain specific binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, spermidine transmembrane transporter activity, transcription cis-regulatory region binding; CC: cytoplasm, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Herpes simplex virus 1 infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), RNA Polymerase II Transcription, RNA polymerase II transcribes snRNA genes
UniProt: Q00196
Entrez ID: 18987
|
Does Knockout of Gpr15 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Gpr15
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Gpr15 (G protein-coupled receptor 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, T cell migration, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, angiogenesis, signal transduction, symbiont entry into host cell; MF: G protein-coupled receptor activity, coreceptor activity, virus receptor activity; CC: cytoplasm, endosome, membrane, plasma membrane
Pathways: G alpha (s) signalling events, GPCR downstream signalling, Signal Transduction, Signaling by GPCR
UniProt: Q0VDU3
Entrez ID: 71223
|
Does Knockout of Fut4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Fut4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Fut4 (fucosyltransferase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Lewis x epitope biosynthetic process, fucosylation, glycosphingolipid biosynthetic process, inflammatory response, lymphocyte migration into lymph node, oligosaccharide metabolic process, positive regulation of leukocyte tethering or rolling, positive regulation of neutrophil migration, protein N-linked glycosylation, protein O-linked glycosylation, protein glycosylation, regulation of leukocyte cell-cell adhesion; MF: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity, alpha-(1->3)-fucosyltransferase activity, fucosyltransferase activity, glycosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, cell periphery, cell surface, membrane, trans-Golgi network
Pathways: Blood group systems biosynthesis, Glycosphingolipid biosynthesis - lacto and neolacto series - Mus musculus (mouse), Lewis blood group biosynthesis, Mannose type O-glycan biosynthesis - Mus musculus (mouse), Metabolism, Metabolism of carbohydrates and carbohydrate derivatives
UniProt: Q11127
Entrez ID: 14345
|
Does Knockout of Shq1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Shq1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Shq1 (SHQ1 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: box H/ACA snoRNP assembly, positive regulation of TORC1 signaling, protein-RNA complex assembly, regulation of androgen receptor signaling pathway; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Cell Cycle, Chromosome Maintenance, Extension of Telomeres, Telomere Extension By Telomerase, Telomere Maintenance
UniProt: Q7TMX5
Entrez ID: 72171
|
Does Knockout of Vsig8 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Vsig8
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Vsig8 (V-set and immunoglobulin domain containing 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6P3A4
Entrez ID: 240916
|
Does Knockout of Mdn1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Mdn1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mdn1 (midasin AAA ATPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit assembly, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, molecular_function, nucleotide binding; CC: cytosol, intermediate filament cytoskeleton, nucleolus, nucleoplasm, nucleus
Pathways: Ribosome biogenesis in eukaryotes - Mus musculus (mouse)
UniProt: A2ANY6, J3QMC5
Entrez ID: 100019
|
Does Knockout of Rsl24d1 in Regulatory T cell causally result in cell proliferation?
| 1
| 1,483
|
Knockout
|
Rsl24d1
|
cell proliferation
|
Regulatory T cell
|
Gene: Rsl24d1 (ribosomal L24 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Ribosome - Mus musculus (mouse)
UniProt: Q99L28
Entrez ID: 225215
|
Does Knockout of Rab21 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,170
|
Knockout
|
Rab21
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rab21 (RAB21, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rab protein signal transduction, anterograde axonal transport, intracellular protein transport, positive regulation of dendrite morphogenesis, positive regulation of early endosome to late endosome transport, positive regulation of receptor-mediated endocytosis, protein stabilization, protein transport, regulation of axon extension, regulation of exocytosis; MF: G protein activity, GDP binding, GTP binding, GTPase activity, hydrolase activity, metal ion binding, nucleotide binding, protein binding; CC: Golgi apparatus, Golgi cisterna membrane, Golgi membrane, axon cytoplasm, cell projection, cleavage furrow, cytoplasmic side of early endosome membrane, cytoplasmic side of plasma membrane, cytoplasmic vesicle, cytoplasmic vesicle membrane, early endosome, early endosome membrane, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, membrane, neuron projection, synapse, trans-Golgi network, vesicle membrane
Pathways: Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, RAB GEFs exchange GTP for GDP on RABs, RAB geranylgeranylation, Rab regulation of trafficking, Vesicle-mediated transport
UniProt: P35282
Entrez ID: 216344
|
Does Knockout of Erv3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Erv3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Erv3 (endogenous retroviral sequence 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DAX3
Entrez ID: 71995
|
Does Knockout of Nr1d1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Nr1d1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nr1d1 (nuclear receptor subfamily 1, group D, member 1)
Type: protein-coding
Summary: This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014].
Gene Ontology: BP: cell differentiation, cellular response to interleukin-1, cellular response to lipopolysaccharide, cellular response to tumor necrosis factor, cholesterol homeostasis, circadian regulation of gene expression, circadian rhythm, circadian temperature homeostasis, glycogen biosynthetic process, hormone-mediated signaling pathway, intracellular glucose homeostasis, intracellular receptor signaling pathway, lipid homeostasis, multicellular organismal-level homeostasis, negative regulation of DNA-templated transcription, negative regulation of astrocyte activation, negative regulation of canonical NF-kappaB signal transduction, negative regulation of cold-induced thermogenesis, negative regulation of inflammatory response, negative regulation of microglial cell activation, negative regulation of neuroinflammatory response, negative regulation of toll-like receptor 4 signaling pathway, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of bile acid biosynthetic process, positive regulation of circadian rhythm, positive regulation of transcription by RNA polymerase II, proteasomal protein catabolic process, protein destabilization, regulation of DNA-templated transcription, regulation of circadian rhythm, regulation of circadian sleep/wake cycle, regulation of fat cell differentiation, regulation of hepatic stellate cell activation, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of lipid metabolic process, regulation of type B pancreatic cell proliferation, response to leptin, rhythmic process; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, E-box binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, heme binding, metal ion binding, nuclear receptor activity, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, transcription corepressor binding, zinc ion binding; CC: cell projection, chromatin, cytoplasm, dendrite, dendritic spine, neuronal cell body, nuclear body, nucleoplasm, nucleus, synapse
Pathways: Circadian rhythm - Mus musculus (mouse), Gene expression (Transcription), Generic Transcription Pathway, Nuclear Receptor transcription pathway, RNA Polymerase II Transcription
UniProt: Q3UV55
Entrez ID: 217166
|
Does Knockout of Rps6ka6 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Rps6ka6
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Rps6ka6 (ribosomal protein S6 kinase polypeptide 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, TORC1 signaling, intracellular signal transduction, negative regulation of ERK1 and ERK2 cascade, negative regulation of embryonic development, negative regulation of mesoderm development; MF: ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, ribosomal protein S6 kinase activity, transferase activity; CC: cytoplasm, cytosol, fibrillar center, mitochondrion, nucleolus, nucleoplasm, nucleus, synapse
Pathways: Activation of NMDA receptors and postsynaptic events, CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling, Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Insulin resistance - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Neuronal System, Neurotransmitter receptors and postsynaptic signal transmission, Neurotrophin signaling pathway - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Post NMDA receptor activation events, Progesterone-mediated oocyte maturation - Mus musculus (mouse), RSK activation, Thermogenesis - Mus musculus (mouse), Transmission across Chemical Synapses, Yersinia infection - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: Q7TPS0
Entrez ID: 67071
|
Does Knockout of Mageb1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Mageb1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mageb1 (MAGE family member B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q60761
Entrez ID: 17145
|
Does Knockout of Mrpl18 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,440
|
Knockout
|
Mrpl18
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Mrpl18 (mitochondrial ribosomal protein L18)
Type: protein-coding
Summary: Predicted to enable 5S rRNA binding activity. Predicted to be involved in rRNA import into mitochondrion. Located in mitochondrion. Is expressed in several structures, including brain; connective tissue; early conceptus; genitourinary system; and gut. Orthologous to human MRPL18 (mitochondrial ribosomal protein L18). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, rRNA import into mitochondrion, translation; MF: 5S rRNA binding, RNA binding, structural constituent of ribosome; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9CQL5
Entrez ID: 67681
|
Does Knockout of Phrf1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Phrf1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Phrf1 (PHD and ring finger domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA processing, transcription by RNA polymerase II; MF: RNA polymerase binding, metal ion binding, protein domain specific binding, zinc ion binding
Pathways:
UniProt: A6H619
Entrez ID: 101471
|
Does Knockout of Usp9y in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Usp9y
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Usp9y (ubiquitin specific peptidase 9, Y chromosome)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, protein deubiquitination, protein ubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity; CC: cytosol, nucleus
Pathways:
UniProt: F8VPU6
Entrez ID: 107868
|
Does Knockout of Hnrnpm in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Hnrnpm
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Hnrnpm (heterogeneous nuclear ribonucleoprotein M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, positive regulation of protein import, positive regulation of protein localization to nucleus, regulation of postsynapse organization; MF: RNA binding, calcium-dependent protein binding, mRNA binding, nucleic acid binding, protein antigen binding, protein domain specific binding; CC: catalytic step 2 spliceosome, cell surface, cytoplasm, glutamatergic synapse, nuclear matrix, nucleoplasm, nucleus, paraspeckles, postsynaptic density, ribonucleoprotein complex, spliceosomal complex, synapse
Pathways: Spliceosome - Mus musculus (mouse)
UniProt: Q9D0E1
Entrez ID: 76936
|
Does Knockout of Pitpna in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Pitpna
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Pitpna (phosphatidylinositol transfer protein, alpha)
Type: protein-coding
Summary: This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signaling and in the production of phosphatidylinositol 3,4,5-trisphosphate by phosphoinositide-3-kinase. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: axonogenesis, intermembrane lipid transfer, lipid transport, phospholipid transport; MF: fatty-acyl-CoA binding, lipid binding, phosphatidylcholine binding, phosphatidylcholine transfer activity, phosphatidylcholine transporter activity, phosphatidylinositol binding, phosphatidylinositol transfer activity, phospholipid binding, phospholipid transporter activity, stearic acid binding; CC: cytoplasm, cytosol, membrane, myelin sheath, nucleus
Pathways:
UniProt: P53810
Entrez ID: 18738
|
Does Knockout of Klc1 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Klc1
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Klc1 (kinesin light chain 1)
Type: protein-coding
Summary: Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named 'kinesin 2', this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: axo-dendritic transport, cell adhesion, intracellular protein transport, microtubule-based movement, protein localization to synapse, stress granule disassembly; MF: kinesin binding, protein binding, tubulin binding; CC: axon, cell projection, ciliary rootlet, cytoplasm, cytoplasmic vesicle, cytoskeleton, cytosol, growth cone, kinesin complex, membrane, microtubule, neuron projection, neuronal cell body, vesicle
Pathways: Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse)
UniProt: Q8CD76, Q5UE59, Q7TNF4, Q7M6Z8, Q7M6Z7, A0A5F8MPZ2, Q7M702, Q7M6Z9, Q7M701, E9Q7C9, F6UYN4
Entrez ID: 16593
|
Does Knockout of Gm11627 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,285
|
Knockout
|
Gm11627
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gm11627 (predicted gene 11627)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100040792
|
Does Knockout of Camsap3 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Camsap3
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Camsap3 (calmodulin regulated spectrin-associated protein family, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium movement, cytoplasmic microtubule organization, embryo development ending in birth or egg hatching, epithelial cell-cell adhesion, establishment of epithelial cell apical/basal polarity, establishment or maintenance of microtubule cytoskeleton polarity, in utero embryonic development, microtubule anchoring, microtubule cytoskeleton organization, negative regulation of microtubule depolymerization, neuron projection development, protein transport along microtubule, regulation of Golgi organization, regulation of cell migration, regulation of focal adhesion assembly, regulation of microtubule cytoskeleton organization, regulation of microtubule polymerization, regulation of organelle organization, zonula adherens maintenance; MF: actin filament binding, calmodulin binding, microtubule binding, microtubule minus-end binding, protein binding, spectrin binding; CC: adherens junction, anchoring junction, axoneme, cell projection, centrosome, ciliary basal body, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, microtubule minus-end, motile cilium, zonula adherens
Pathways:
UniProt: Q80VC9
Entrez ID: 69697
|
Does Knockout of Zcchc3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Zcchc3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zcchc3 (zinc finger, CCHC domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, cellular response to exogenous dsRNA, defense response to virus, detection of virus, immune system process, innate immune response, positive regulation of RIG-I signaling pathway, positive regulation of type I interferon production; MF: DNA binding, RNA binding, double-stranded DNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: cytoplasm
Pathways:
UniProt: Q8BPK2
Entrez ID: 67917
|
Does Knockout of Lrig3 in Melanoma Cell Line causally result in tumorigenicity?
| 0
| 2,187
|
Knockout
|
Lrig3
|
tumorigenicity
|
Melanoma Cell Line
|
Gene: Lrig3 (leucine-rich repeats and immunoglobulin-like domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: otolith morphogenesis; CC: cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, plasma membrane
Pathways:
UniProt: Q6P1C6
Entrez ID: 320398
|
Does Knockout of Dbndd2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Dbndd2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Dbndd2 (dysbindin domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERK1 and ERK2 cascade, apoptotic process, monoatomic ion homeostasis, negative regulation of protein kinase activity, neurogenesis, neuron projection development, regulation of signal transduction; MF: ATPase binding, molecular_function, protein binding; CC: cytoplasm, endoplasmic reticulum, lysosome
Pathways:
UniProt: Q9CRD4
Entrez ID: 52840
|
Does Knockout of Stk35 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Stk35
|
phagocytosis
|
macrophage
|
Gene: Stk35 (serine/threonine kinase 35)
Type: protein-coding
Summary: Predicted to enable protein kinase activity. Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of G2/MI transition of meiotic cell cycle. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including bone; cerebellum; gonad; pelvic girdle skeleton; and sensory organ. Orthologous to human STK35 (serine/threonine kinase 35). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of G2/M transition of mitotic cell cycle, negative regulation of G2/MI transition of meiotic cell cycle; MF: ATP binding, kinase activity, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, nuclear body, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q80ZW0
Entrez ID: 67333
|
Does Knockout of Ankrd45 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Ankrd45
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ankrd45 (ankyrin repeat domain 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation; CC: Flemming body, centrosome, cleavage furrow, cytoplasm, cytosol, midbody, plasma membrane
Pathways:
UniProt: Q810N6
Entrez ID: 73844
|
Does Knockout of Vsx2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Vsx2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Vsx2 (visual system homeobox 2)
Type: protein-coding
Summary: This gene encodes a member of the Vsx (visual system homeobox) family which belongs to the larger PRD homeobox class. The encoded protein is required for eye organogenesis and controls retinal development. Disruption of this gene is associated with ocular retardation J (orJ), a mouse disease which causes microphthalmia, retinal degeneration and optic nerve aplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: camera-type eye development, cell fate commitment, central nervous system neuron differentiation, negative regulation of neuroblast proliferation, negative regulation of transcription by RNA polymerase II, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, retina morphogenesis in camera-type eye, retinal bipolar neuron differentiation, visual perception; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding, sequence-specific double-stranded DNA binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q61412
Entrez ID: 12677
|
Does Knockout of Akap1 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,264
|
Knockout
|
Akap1
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Akap1 (A kinase anchor protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, apoptotic process, negative regulation of cell growth involved in cardiac muscle cell development, negative regulation of dephosphorylation, negative regulation of protein import into nucleus; MF: RNA binding, beta-tubulin binding, microtubule binding, molecular adaptor activity, nucleic acid binding, protein binding, protein kinase A regulatory subunit binding, protein kinase binding, protein phosphatase binding; CC: endoplasmic reticulum, lipid droplet, membrane, mitochondrial crista, mitochondrial membrane, mitochondrial outer membrane, mitochondrion, neuromuscular junction, postsynaptic membrane, postsynaptic specialization, intracellular component
Pathways: Factors involved in megakaryocyte development and platelet production, Hemostasis
UniProt: O08715
Entrez ID: 11640
|
Does Knockout of Plxnb3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Plxnb3
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Plxnb3 (plexin B3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of GTPase activity, negative regulation of cell adhesion, negative regulation of cell migration, negative regulation of lamellipodium assembly, nervous system development, positive chemotaxis, positive regulation of axonogenesis, positive regulation of endothelial cell proliferation, positive regulation of neuron projection development, regulation of cell shape, semaphorin-plexin signaling pathway, synapse assembly; MF: Rho GDP-dissociation inhibitor binding, cell-cell adhesion mediator activity, protein binding, protein domain specific binding, semaphorin receptor activity; CC: cell surface, membrane, plasma membrane, semaphorin receptor complex
Pathways: Axon guidance, Axon guidance - Mus musculus (mouse), Developmental Biology, Nervous system development, Other semaphorin interactions, Semaphorin interactions
UniProt: Q9QY40
Entrez ID: 140571
|
Does Knockout of Tcl1b3 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Tcl1b3
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Tcl1b3 (T cell leukemia/lymphoma 1B, 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction; MF: protein kinase binding, protein serine/threonine kinase activator activity
Pathways:
UniProt: P56842
Entrez ID: 27378
|
Does Knockout of Atg12 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,680
|
Knockout
|
Atg12
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Atg12 (autophagy related 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagosome maturation, autophagy, autophagy of mitochondrion, glycophagy, macroautophagy, negative regulation of defense response to virus, negative regulation of innate immune response, negative regulation of type I interferon production, piecemeal microautophagy of the nucleus, positive regulation of viral translation, regulation of autophagosome maturation; MF: Atg8-family ligase activity, protein binding, protein tag activity; CC: Atg12-Atg5-Atg16 complex, autophagosome, autophagosome membrane, cytoplasm, cytosol, membrane, nucleoplasm, phagophore assembly site membrane, protein-containing complex, transferase complex
Pathways: Autophagy, Autophagy - animal - Mus musculus (mouse), Autophagy - other - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), Macroautophagy, Mitophagy, NOD-like receptor signaling pathway - Mus musculus (mouse), PINK1-PRKN Mediated Mitophagy, RIG-I-like receptor signaling pathway - Mus musculus (mouse), Receptor Mediated Mitophagy, Selective autophagy
UniProt: Q9CQY1
Entrez ID: 67526
|
Does Knockout of Runx1t1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Runx1t1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Runx1t1 (RUNX1 translocation partner 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in negative regulation of fat cell differentiation. Acts upstream of or within fat cell differentiation and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human RUNX1T1 (RUNX1 partner transcriptional co-repressor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA-templated transcription, fat cell differentiation, negative regulation of DNA-templated transcription, negative regulation of fat cell differentiation, negative regulation of neuron projection development, regulation of DNA-templated transcription; MF: DNA-binding transcription factor binding, identical protein binding, metal ion binding, protein binding, transcription corepressor activity, zinc ion binding; CC: nuclear matrix, nucleoplasm, nucleus, transcription repressor complex
Pathways: Acute myeloid leukemia - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Transcriptional misregulation in cancer - Mus musculus (mouse)
UniProt: Q61909
Entrez ID: 12395
|
Does Knockout of Camta2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Camta2
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Camta2 (calmodulin binding transcription activator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle hypertrophy in response to stress, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: DNA binding, chromatin binding, double-stranded DNA binding, histone deacetylase binding, sequence-specific DNA binding, transcription coactivator activity, transcription coregulator activity; CC: chromatin, nucleus
Pathways:
UniProt: Q80Y50
Entrez ID: 216874
|
Does Knockout of Rps16 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Rps16
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Rps16 (ribosomal protein S16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to leukemia inhibitory factor, cytoplasmic translation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosomal small subunit biogenesis, translation, translation at postsynapse, translation at presynapse; MF: RNA binding, structural constituent of ribosome; CC: cytoplasm, cytosol, cytosolic ribosome, cytosolic small ribosomal subunit, nucleolus, nucleus, postsynapse, presynapse, ribonucleoprotein complex, ribosome, small ribosomal subunit, small-subunit processome, synapse
Pathways: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, Cap-dependent Translation Initiation, Coronavirus disease - COVID-19 - Mus musculus (mouse), Eukaryotic Translation Initiation, Formation of a pool of free 40S subunits, Formation of the ternary complex, and subsequently, the 43S complex, GTP hydrolysis and joining of the 60S ribosomal subunit, L13a-mediated translational silencing of Ceruloplasmin expression, Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Metabolism of proteins, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC), Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC), Nonsense-Mediated Decay (NMD), PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA, Ribosomal scanning and start codon recognition, Ribosome - Mus musculus (mouse), Ribosome-associated quality control, SRP-dependent cotranslational protein targeting to membrane, Translation, Translation initiation complex formation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: P14131
Entrez ID: 20055
|
Does Knockout of Gm266 in breast epithelium causally result in cell cycle progression?
| 0
| 1,469
|
Knockout
|
Gm266
|
cell cycle progression
|
breast epithelium
|
Gene: Gm266 (predicted gene 266)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rap protein signal transduction, negative regulation of cell migration, signal transduction; MF: GDP binding, GTP binding, GTPase activity; CC: endomembrane system, membrane, plasma membrane
Pathways:
UniProt: A6H634
Entrez ID: 212539
|
Does Knockout of Gba2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Gba2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Gba2 (glucosidase beta 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid metabolic process, carbohydrate metabolic process, central nervous system development, central nervous system neuron development, cholesterol metabolic process, glucosylceramide catabolic process, glycolipid biosynthetic process, glycoside catabolic process, lipid metabolic process, regulation of actin filament polymerization, regulation of membrane lipid distribution, regulation of microtubule polymerization, small molecule metabolic process, sphingolipid metabolic process, steroid metabolic process; MF: beta-glucosidase activity, galactosylceramidase activity, glucosylceramidase activity, glucosyltransferase activity, glycosyltransferase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds, hydrolase activity, hydrolyzing O-glycosyl compounds, steryl-beta-glucosidase activity, transferase activity; CC: Golgi apparatus, Golgi membrane, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Glycosphingolipid catabolism, Glycosphingolipid metabolism, Metabolism, Metabolism of lipids, Other glycan degradation - Mus musculus (mouse), Sphingolipid metabolism, Sphingolipid metabolism - Mus musculus (mouse)
UniProt: Q69ZF3
Entrez ID: 230101
|
Does Knockout of Il22 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Il22
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Il22 (interleukin 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cytokine production involved in inflammatory response, negative regulation of inflammatory response, positive regulation of inflammatory response, positive regulation of transcription by RNA polymerase II, reactive oxygen species metabolic process, signal transduction; MF: cytokine activity, protein binding; CC: extracellular region, extracellular space
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Immune System, Inflammatory bowel disease - Mus musculus (mouse), Interleukin-20 family signaling, JAK-STAT signaling pathway - Mus musculus (mouse), Signaling by Interleukins, Th17 cell differentiation - Mus musculus (mouse)
UniProt: Q9JJY9
Entrez ID: 50929
|
Does Knockout of Prlr in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Prlr
|
phagocytosis
|
macrophage
|
Gene: Prlr (prolactin receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cytokine-mediated signaling pathway, lactation, mammary gland alveolus development, mammary gland epithelial cell differentiation, mammary gland epithelium development, negative regulation of apoptotic process, positive regulation of B cell proliferation, positive regulation of cell population proliferation, positive regulation of cold-induced thermogenesis, prolactin signaling pathway, prostate gland growth, regulation of cell adhesion, regulation of epithelial cell differentiation, response to bacterium; MF: cytokine binding, cytokine receptor activity, lipid binding, metal ion binding, peptide hormone binding, prolactin receptor activity, protein binding, protein kinase binding; CC: cell surface, external side of plasma membrane, membrane, receptor complex
Pathways: Cytokine Signaling in Immune system, Cytokine-cytokine receptor interaction - Mus musculus (mouse), Growth hormone receptor signaling, Immune System, JAK-STAT signaling pathway - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), PI3K-Akt signaling pathway - Mus musculus (mouse), Prolactin receptor signaling, Prolactin signaling pathway - Mus musculus (mouse)
UniProt: Q08501
Entrez ID: 19116
|
Does Knockout of Zfr2 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,275
|
Knockout
|
Zfr2
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Zfr2 (zinc finger RNA binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: double-stranded RNA binding, molecular_function, nucleic acid binding, single-stranded RNA binding, zinc ion binding
Pathways:
UniProt: F6VRB4, E9Q5M4, D3YXQ2
Entrez ID: 103406
|
Does Knockout of Sox2 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Sox2
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Sox2 (SRY (sex determining region Y)-box 2)
Type: protein-coding
Summary: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot). [provided by RefSeq, Sep 2015].
Gene Ontology: BP: adenohypophysis development, anatomical structure formation involved in morphogenesis, brain development, cell fate commitment, cell fate specification, cellular response to cadmium ion, cerebral cortex development, detection of mechanical stimulus involved in equilibrioception, detection of mechanical stimulus involved in sensory perception of sound, diencephalon morphogenesis, embryonic organ development, endodermal cell fate specification, epithelial tube branching involved in lung morphogenesis, forebrain development, forebrain neuron differentiation, gene expression, inner ear development, inner ear morphogenesis, lens induction in camera-type eye, lung alveolus development, male genitalia development, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of cell cycle G1/S phase transition, negative regulation of cell differentiation, negative regulation of neuron differentiation, negative regulation of osteoblast differentiation, negative regulation of transcription by RNA polymerase II, neuron differentiation, neuron fate commitment, neuronal stem cell population maintenance, olfactory placode formation, osteoblast differentiation, pigment biosynthetic process, positive regulation of DNA-templated transcription, positive regulation of MAPK cascade, positive regulation of Notch signaling pathway, positive regulation of cell differentiation, positive regulation of cell-cell adhesion, positive regulation of epithelial cell differentiation, positive regulation of neuroblast proliferation, positive regulation of neuron differentiation, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of gene expression, regulation of myofibroblast cell apoptotic process, regulation of neurogenesis, regulation of transcription by RNA polymerase II, response to growth factor, response to oxygen-glucose deprivation, response to retinoic acid, retina morphogenesis in camera-type eye, sensory perception of sound, somatic stem cell population maintenance, stem cell differentiation, stem cell population maintenance, tongue development, trophectodermal cell differentiation; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin DNA binding, chromatin binding, miRNA binding, nitric-oxide synthase binding, protein binding, sequence-specific DNA binding, transcription cis-regulatory region binding; CC: chromatin, cytoplasm, cytosol, nucleoplasm, nucleus, transcription regulator complex
Pathways: Deactivation of the beta-catenin transactivating complex, Hippo signaling pathway - Mus musculus (mouse), Signal Transduction, Signaling by WNT, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), TCF dependent signaling in response to WNT
UniProt: P48432
Entrez ID: 20674
|
Does Knockout of Gabrd in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Gabrd
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Gabrd (gamma-aminobutyric acid (GABA) A receptor, subunit delta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-cell signaling, chemical synaptic transmission, chloride transmembrane transport, chloride transport, gamma-aminobutyric acid signaling pathway, monoatomic ion transmembrane transport, monoatomic ion transport, regulation of postsynaptic membrane potential, synaptic transmission, GABAergic; MF: GABA-A receptor activity, chloride channel activity, extracellular ligand-gated monoatomic ion channel activity, monoatomic ion channel activity, transmembrane signaling receptor activity, transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; CC: GABA-A receptor complex, GABA-ergic synapse, axon, chloride channel complex, dendrite, glutamatergic synapse, membrane, neuronal cell body, plasma membrane, postsynaptic membrane
Pathways: GABAergic synapse - Mus musculus (mouse), Morphine addiction - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Nicotine addiction - Mus musculus (mouse), Retrograde endocannabinoid signaling - Mus musculus (mouse)
UniProt: P22933
Entrez ID: 14403
|
Does Knockout of Iqcf3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Iqcf3
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Iqcf3 (IQ motif containing F3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D498
Entrez ID: 68265
|
Does Knockout of Wdr26 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Wdr26
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Wdr26 (WD repeat domain 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: GID complex, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate metabolism, Regulation of pyruvate metabolism
UniProt: Q8C6G8
Entrez ID: 226757
|
Does Knockout of Fundc1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Fundc1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fundc1 (FUN14 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, autophagy of mitochondrion, mitochondrial fusion, mitophagy, response to hypoxia; CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways: Autophagy, Macroautophagy, Mitophagy, Mitophagy - animal - Mus musculus (mouse), Receptor Mediated Mitophagy, Selective autophagy
UniProt: Q9DB70
Entrez ID: 72018
|
Does Knockout of Tnnt3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Tnnt3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tnnt3 (troponin T3, skeletal, fast)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of muscle contraction, regulation of striated muscle contraction, sarcomere organization, skeletal muscle contraction; MF: actin binding, calcium-dependent protein binding, tropomyosin binding, troponin C binding, troponin I binding; CC: troponin complex
Pathways: Muscle contraction, Striated Muscle Contraction
UniProt: Q9QZ47
Entrez ID: 21957
|
Does Knockout of Eif5a2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 1,664
|
Knockout
|
Eif5a2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Eif5a2 (eukaryotic translation initiation factor 5A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of translational elongation, positive regulation of translational termination, translation, translational elongation; MF: RNA binding, ribosome binding, translation elongation factor activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation, Hypusine synthesis from eIF5A-lysine, Metabolism of proteins, Post-translational protein modification
UniProt: Q8BGY2
Entrez ID: 208691
|
Does Knockout of Tjap1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Tjap1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tjap1 (tight junction associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization; CC: Golgi apparatus, anchoring junction, bicellular tight junction, cytoplasm, endosome, membrane, plasma membrane, trans-Golgi network
Pathways: Tight junction - Mus musculus (mouse)
UniProt: Q9DCD5
Entrez ID: 74094
|
Does Knockout of Sptssb in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Sptssb
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Sptssb (serine palmitoyltransferase, small subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, endoplasmic reticulum organization, lipid metabolic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphingosine biosynthetic process; MF: serine C-palmitoyltransferase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, serine palmitoyltransferase complex
Pathways: Metabolism, Metabolism of lipids, Sphingolipid de novo biosynthesis, Sphingolipid metabolism
UniProt: Q925E8
Entrez ID: 66183
|
Does Knockout of Klb in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Klb
|
cell proliferation
|
Regulatory T cell
|
Gene: Klb (klotho beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, fibroblast growth factor receptor signaling pathway, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation of cell population proliferation; MF: fibroblast growth factor binding, fibroblast growth factor receptor binding, hydrolase activity, hydrolyzing O-glycosyl compounds, protein binding; CC: membrane, plasma membrane
Pathways: Downstream signaling of activated FGFR4, FGFR4 ligand binding and activation, FRS-mediated FGFR4 signaling, IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Negative regulation of FGFR4 signaling, Negative regulation of the PI3K/AKT network, PI-3K cascade:FGFR4, PI3K Cascade, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phospholipase C-mediated cascade; FGFR4, RAF/MAP kinase cascade, SHC-mediated cascade:FGFR4, Signal Transduction, Signaling by FGFR, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Thermogenesis - Mus musculus (mouse), betaKlotho-mediated ligand binding
UniProt: Q99N32
Entrez ID: 83379
|
Does Knockout of Arhgap26 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 2,403
|
Knockout
|
Arhgap26
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Arhgap26 (Rho GTPase activating protein 26)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity; phospholipid binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in mitophagy. Predicted to be located in cytosol and endosome membrane. Predicted to be active in mitochondrion. Is expressed in amygdala; diencephalon lateral wall mantle layer; hypothalamus mantle layer; olfactory epithelium; and telencephalon mantle layer. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia and juvenile myelomonocytic leukemia. Orthologous to human ARHGAP26 (Rho GTPase activating protein 26). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: mitophagy, signal transduction; MF: GTPase activator activity, phospholipid binding, protein binding, protein-macromolecule adaptor activity; CC: anchoring junction, cytoplasm, cytoskeleton, cytosol, endosome, endosome membrane, focal adhesion, membrane, mitochondrion
Pathways: CDC42 GTPase cycle, RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6ZQ82
Entrez ID: 71302
|
Does Knockout of Rbm38 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Rbm38
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Rbm38 (RNA binding motif protein 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, DNA damage response, signal transduction by p53 class mediator, RNA splicing, cell differentiation, mRNA processing, negative regulation of cell population proliferation, regulation of RNA splicing, regulation of cell cycle, regulation of myotube differentiation; MF: RNA binding, mRNA 3'-UTR binding, mRNA binding, nucleic acid binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q62176
Entrez ID: 56190
|
Does Knockout of Pacsin3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Pacsin3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Pacsin3 (protein kinase C and casein kinase substrate in neurons 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, endocytosis, negative regulation of calcium ion transport, negative regulation of endocytosis, plasma membrane tubulation, positive regulation of membrane protein ectodomain proteolysis, regulation of endocytosis; MF: calcium channel inhibitor activity, cytoskeletal protein binding, identical protein binding, lipid binding, phospholipid binding, protein binding; CC: cytoplasm, cytosol, endosome, membrane, plasma membrane
Pathways: Clathrin-mediated endocytosis, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q99JB8
Entrez ID: 80708
|
Does Knockout of Defb38 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Defb38
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Defb38 (defensin beta 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, innate immune response in mucosa, response to bacterium; CC: extracellular region, extracellular space
Pathways:
UniProt: Q7TNV7
Entrez ID: 360212
|
Does Knockout of Kcne4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Kcne4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Kcne4 (potassium voltage-gated channel, Isk-related subfamily, gene 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: membrane repolarization during action potential, membrane repolarization during ventricular cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion export across plasma membrane, potassium ion transmembrane transport, potassium ion transport, regulation of heart rate by cardiac conduction, regulation of ventricular cardiac muscle cell membrane repolarization, ventricular cardiac muscle cell action potential; MF: delayed rectifier potassium channel activity, potassium channel activity, potassium channel inhibitor activity, potassium channel regulator activity, protein binding, transmembrane transporter binding, voltage-gated potassium channel activity, voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization; CC: apical plasma membrane, membrane, monoatomic ion channel complex, voltage-gated potassium channel complex
Pathways: Cardiac conduction, Muscle contraction, Phase 2 - plateau phase, Phase 3 - rapid repolarisation
UniProt: Q9WTW3
Entrez ID: 57814
|
Does Knockout of Prkcsh in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,180
|
Knockout
|
Prkcsh
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Prkcsh (protein kinase C substrate 80K-H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-glycan processing, in utero embryonic development, liver development, negative regulation of neuron projection development, nitrogen cycle metabolic process; MF: RNA binding, calcium ion binding, metal ion binding, phosphoprotein binding, protein binding, protein kinase C binding, protein-containing complex binding, transmembrane transporter binding; CC: endoplasmic reticulum, glucosidase II complex, intracellular membrane-bounded organelle
Pathways: Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: O08795
Entrez ID: 19089
|
Does Knockout of Prom2 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Prom2
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Prom2 (prominin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of caveolin-mediated endocytosis, negative regulation of pinocytosis, positive regulation of cell projection organization; MF: cholesterol binding; CC: apical plasma membrane, basolateral plasma membrane, cell projection, cell surface, ciliary membrane, cilium, cytoplasmic vesicle, membrane, membrane raft, microspike, microvillus, microvillus membrane, plasma membrane, prominosome
Pathways:
UniProt: Q3UUY6
Entrez ID: 192212
|
Does Knockout of Cilp in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Cilp
|
response to virus
|
Microglial Cell Line
|
Gene: Cilp (cartilage intermediate layer protein, nucleotide pyrophosphohydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of SMAD protein signal transduction, negative regulation of gene expression, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of transforming growth factor beta receptor signaling pathway; CC: extracellular matrix, extracellular region, extracellular space
Pathways: Signal Transduction, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: Q66K08
Entrez ID: 214425
|
Does Knockout of Snapc4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Snapc4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Snapc4 (small nuclear RNA activating complex, polypeptide 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III; MF: DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II general transcription initiation factor activity, RNA polymerase III general transcription initiation factor activity, RNA polymerase III type 3 promoter sequence-specific DNA binding; CC: nucleus, snRNA-activating protein complex
Pathways: Gene expression (Transcription), RNA Polymerase II Transcription, RNA Polymerase III Transcription, RNA Polymerase III Transcription Initiation, RNA Polymerase III Transcription Initiation From Type 3 Promoter, RNA polymerase II transcribes snRNA genes
UniProt: Q8BP86
Entrez ID: 227644
|
Does Knockout of Arhgap35 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Arhgap35
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Arhgap35 (Rho GTPase activating protein 35)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, axon guidance, axonal fasciculation, camera-type eye development, cell migration, central nervous system neuron axonogenesis, establishment or maintenance of actin cytoskeleton polarity, forebrain development, integrin-mediated signaling pathway, mammary gland development, negative regulation of Rho protein signal transduction, negative regulation of vascular permeability, neural tube closure, neuron projection guidance, positive regulation of GTPase activity, positive regulation of cilium assembly, positive regulation of neuron projection development, regulation of actin cytoskeleton organization, regulation of actin polymerization or depolymerization, regulation of axonogenesis, regulation of cell shape, regulation of cell size, regulation of cellular component size, regulation of small GTPase mediated signal transduction, signal transduction, wound healing, spreading of cells; MF: DNA binding, GTP binding, GTPase activating protein binding, GTPase activator activity, GTPase activity, lipid binding, nucleotide binding, phospholipid binding, protein-containing complex binding; CC: actin cytoskeleton, cell projection, ciliary basal body, cytoplasm, cytoskeleton, cytosol, membrane, nucleus, plasma membrane
Pathways: Axon guidance, CDC42 GTPase cycle, Developmental Biology, Focal adhesion - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Nervous system development, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, Platelet activation - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, RHOC GTPase cycle, RHOD GTPase cycle, RHOG GTPase cycle, RHOJ GTPase cycle, RHOQ GTPase cycle, RND1 GTPase cycle, RND2 GTPase cycle, RND3 GTPase cycle, Regulation of actin cytoskeleton - Mus musculus (mouse), Sema4D in semaphorin signaling, Sema4D mediated inhibition of cell attachment and migration, Semaphorin interactions, Signal Transduction, Signaling by Non-Receptor Tyrosine Kinases, Signaling by PTK6, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q91YM2
Entrez ID: 232906
|
Does Knockout of Zscan30 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Zscan30
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Zscan30 (zinc finger and SCAN domain containing 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q149X8
Entrez ID: 328918
|
Does Knockout of Stx5a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Stx5a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Stx5a (syntaxin 5A)
Type: protein-coding
Summary: Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and regulation of Golgi organization. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in Golgi apparatus and vesicle. Predicted to be part of SNARE complex. Predicted to be active in Golgi membrane. Is expressed in mesenchyme of metanephros and metanephros epithelium. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human STX5 (syntaxin 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi disassembly, early endosome to Golgi transport, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, positive regulation of protein catabolic process, regulation of Golgi organization, retrograde transport, endosome to Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle docking, vesicle fusion, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding; CC: Golgi apparatus, Golgi membrane, SNARE complex, cytosol, endomembrane system, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, vesicle
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein localization, RHO GTPase cycle, RHOA GTPase cycle, RHOC GTPase cycle, RHOG GTPase cycle, SNARE interactions in vesicular transport - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q8K1E0
Entrez ID: 56389
|
Does Knockout of Prdm12 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,398
|
Knockout
|
Prdm12
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Prdm12 (PR domain containing 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of temperature stimulus involved in sensory perception of pain, negative regulation of transcription by RNA polymerase II, neurogenesis, neuron fate specification, neuron projection development, positive regulation of transcription by RNA polymerase II, regulation of gene expression, sensory perception of pain; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, histone chaperone activity, histone methyltransferase binding, metal ion binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: A2AJ77
Entrez ID: 381359
|
Does Knockout of Peg3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Peg3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Peg3 (paternally expressed 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II transcription regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding; CC: autophagosome, cytoplasm, nucleus
Pathways:
UniProt: Q3URU2
Entrez ID: 18616
|
Does Knockout of Hsd17b13 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Hsd17b13
|
response to bacteria
|
macrophage
|
Gene: Hsd17b13 (hydroxysteroid (17-beta) dehydrogenase 13)
Type: protein-coding
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within positive regulation of lipid biosynthetic process. Located in lipid droplet. Orthologous to human HSD17B13 (hydroxysteroid 17-beta dehydrogenase 13). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: lipid metabolic process, positive regulation of lipid biosynthetic process; MF: all-trans-retinol dehydrogenase (NAD+) activity, estradiol 17-beta-dehydrogenase [NAD(P)+] activity, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, steroid dehydrogenase activity; CC: endoplasmic reticulum, lipid droplet
Pathways: Lipid particle organization, Metabolism, Metabolism of lipids
UniProt: Q8VCR2
Entrez ID: 243168
|
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