prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Cyp3a13 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Cyp3a13 | response to virus | Embryonic Fibroblast Cell Line | Gene: Cyp3a13 (cytochrome P450, family 3, subfamily a, polypeptide 13)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: oxidative demethylation, positive regulation of gene expression, steroid metabolic process, xenobiotic transport; MF: 1-alpha,25-dihydroxyvitamin D3 23-h... |
Does Knockout of Rhbdf1 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Rhbdf1 | cell cycle progression | breast epithelium | Gene: Rhbdf1 (rhomboid 5 homolog 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, cell population proliferation, negative regulation of protein secretion, regulation of epidermal growth factor receptor signaling pathway, regulation of proteasomal protein... |
Does Knockout of Slc2a9 in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Slc2a9 | response to bacteria | macrophage | Gene: Slc2a9 (solute carrier family 2 (facilitated glucose transporter), member 9)
Type: protein-coding
Summary: Enables D-glucose transmembrane transporter activity and urate transmembrane transporter activity. Involved in urate transport. Acts upstream of or within D-glucose transmembrane transport. L... |
Does Knockout of Klk1b4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Klk1b4 | protein/peptide distribution | myoblast cell line | Gene: Klk1b4 (kallikrein 1-related pepidase b4)
Type: protein-coding
Summary: This gene encodes the alpha subunit of the 7S nerve growth factor (NGF) complex that is essential for the differentiation and survival of distinct populations of neurons in both the central and the peripheral nervous systems. ... |
Does Knockout of Lyst in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,172 | Knockout | Lyst | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Lyst (lysosomal trafficking regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T cell mediated immunity, blood coagulation, defense response to bacterium, defense response to other organism, defense response to protozoan, defense response to virus, endosome ... |
Does Knockout of Slc25a44 in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,178 | Knockout | Slc25a44 | tumorigenicity | Colonic Cancer Cell Line | Gene: Slc25a44 (solute carrier family 25, member 44)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: amino acid transport, branched-chain amino acid catabolic process, branched-chain amino acid transport, regulation of cold-induced thermogenesis, transmembrane transport; ... |
Does Knockout of Coq7 in Melanoma Cell Line causally result in response to chemicals? | 0 | 2,490 | Knockout | Coq7 | response to chemicals | Melanoma Cell Line | Gene: Coq7 (demethyl-Q 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to oxidative stress, determination of adult lifespan, in utero embryonic development, mitochondrial ATP synthesis coupled electron transport, mitochondrion organization, negative r... |
Does Knockout of Fnta in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Fnta | protein/peptide accumulation | Embryonic Cell Line | Gene: Fnta (farnesyltransferase, CAAX box, alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: enzyme-linked receptor protein signaling pathway, negative regulation of apoptotic process, nuclear envelope organization, peptide pheromone maturation, positive regulation o... |
Does Knockout of Hnrnpd in Mouse kidney carcinoma cell causally result in cell proliferation? | 1 | 1,289 | Knockout | Hnrnpd | cell proliferation | Mouse kidney carcinoma cell | Gene: Hnrnpd (heterogeneous nuclear ribonucleoprotein D)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, CRD-mediated mRNA stabilization, cellular response to amino acid stimulus, cellular response to estradiol stimulus, cellular resp... |
Does Knockout of Tmem8b in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Tmem8b | cell proliferation | Mouse kidney carcinoma cell | Gene: Tmem8b (transmembrane protein 8B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, cell-matrix adhesion; CC: cell surface, cytoplasm, endoplasmic reticulum, membrane, mitochondrion, nucleus, plasma membrane
Pathways:
UniProt: B1AWJ5
... |
Does Knockout of Krt12 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,172 | Knockout | Krt12 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Krt12 (keratin 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cornea development in camera-type eye, epithelial cell differentiation, epithelium development, intermediate filament organization, morphogenesis of an epithelium; MF: structural constituent of skin ... |
Does Knockout of 1810055G02Rik in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | 1810055G02Rik | phagocytosis | macrophage | Gene: 1810055G02Rik (RIKEN cDNA 1810055G02 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, membrane, nucleoplasm, plasma membrane
Pathways:
UniProt: Q9D8N1
Entrez ID: 72056 |
Does Knockout of Mutyh in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,267 | Knockout | Mutyh | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Mutyh (mutY DNA glycosylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, base-excision repair, mismatch repair, negative regulation of necroptotic process, response to oxidative stress, response to stress; MF: 4 iron, 4 sulfur cl... |
Does Knockout of Kif12 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Kif12 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Kif12 (kinesin family member 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule-based movement, negative regulation of fatty acid biosynthetic process; MF: ATP binding, ATP hydrolysis activity, microtubule binding, microtubule motor activity, nucleotide... |
Does Knockout of Lpar6 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Lpar6 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Lpar6 (lysophosphatidic acid receptor 6)
Type: protein-coding
Summary: Predicted to enable lysophosphatidic acid receptor activity. Acts upstream of or within blastocyst hatching. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Is exp... |
Does Knockout of Bcat1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Bcat1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Bcat1 (branched chain aminotransferase 1, cytosolic)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-leucine biosynthetic process, L-valine biosynthetic process, amino acid biosynthetic process, branched-chain amino acid biosynthetic process, branched-chain amino ... |
Does Knockout of Tcp11l1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Tcp11l1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Tcp11l1 (t-complex 11 like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: microtubule
Pathways:
UniProt: Q8BTG3
Entrez ID: 320554 |
Does Knockout of Mir7670 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Mir7670 | cell cycle progression | breast epithelium | Gene: Mir7670 (microRNA 7670)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase... |
Does Knockout of Gm4204 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Gm4204 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Gm4204 (nucleosome assembly protein 1-like 1 pseudogene)
Type: pseudo
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100043064 |
Does Knockout of Zcchc10 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Zcchc10 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Zcchc10 (zinc finger, CCHC domain containing 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: metal ion binding, molecular_function, nucleic acid binding, zinc ion binding
Pathways:
UniProt: Q9CX48
Entrez ID: 67966 |
Does Knockout of Tmem45a2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Tmem45a2 | cell proliferation | Melanoma Cell Line | Gene: Tmem45a2 (transmembrane protein 45A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8CEZ6, B7ZWJ5
Entrez ID: 69457 |
Does Knockout of Chmp4b in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,273 | Knockout | Chmp4b | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Chmp4b (charged multivesicular body protein 4B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome maturation, autophagy, exit from mitosis, late endosome to lysosome transport, late endosome to vacuole transport via multivesicular body sorting pathway, m... |
Does Knockout of Ebp in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Ebp | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Ebp (EBP cholestenol delta-isomerase)
Type: protein-coding
Summary: This gene encodes a transmembrane protein that localizes to the endoplasmic reticulum. This protein catalyses the conversion of delta8 to delta7 sterols, an important step in sterol biosynthesis. Mutations in this gene are respons... |
Does Knockout of Frat2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,308 | Knockout | Frat2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Frat2 (frequently rearranged in advanced T cell lymphomas 2)
Type: protein-coding
Summary: Acts upstream of or within Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary syste... |
Does Knockout of Mettl16 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Mettl16 | phagocytosis | macrophage | Gene: Mettl16 (methyltransferase 16, N6-methyladenosine)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA methylation, RNA modification, S-adenosylmethionine biosynthetic process, mRNA catabolic process, mRNA destabilization, mRNA processing, methylation, negative regu... |
Does Knockout of Ryk in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Ryk | response to virus | Microglial Cell Line | Gene: Ryk (receptor-like tyrosine kinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, Wnt signaling pathway, planar cell polarity pathway, axon guidance, axonogenesis, cell surface receptor protein tyrosine kinase signaling pathway, chemorepulsi... |
Does Knockout of Flcn in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 1 | 1,268 | Knockout | Flcn | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Flcn (folliculin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, TORC1 signaling, cell-cell junction assembly, cellular response to amino acid starvation, cellular response to nutrient levels,... |
Does Knockout of Lyrm1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Lyrm1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Lyrm1 (LYR motif containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: midbody, mitochondrion, nucleoplasm
Pathways:
UniProt: Q9CQB7
Entrez ID: 73919 |
Does Knockout of Sobp in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Sobp | protein/peptide accumulation | Embryonic Cell Line | Gene: Sobp (sine oculis binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: animal organ development, cochlea development, cognition, inner ear morphogenesis, locomotory behavior, sensory perception of sound; MF: SUMO polymer binding, metal ion binding, zinc ... |
Does Knockout of Rnpc3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,679 | Knockout | Rnpc3 | protein/peptide distribution | myoblast cell line | Gene: Rnpc3 (RNA-binding region (RNP1, RRM) containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA splicing, via spliceosome; MF: RNA binding, U12 snRNA binding, nucleic acid binding, pre-mRNA intronic binding; CC: U12-type spliceosomal complex, ... |
Does Knockout of Tars2 in Microglial Cell Line causally result in protein/peptide distribution? | 0 | 1,585 | Knockout | Tars2 | protein/peptide distribution | Microglial Cell Line | Gene: Tars2 (threonyl-tRNA synthetase 2, mitochondrial (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aminoacyl-tRNA metabolism involved in translational fidelity, tRNA aminoacylation, tRNA aminoacylation for protein translation, threonyl-tRNA aminoacylation,... |
Does Knockout of Gbp3 in Immortal mouse chromaffin cells causally result in cell viability? | 0 | 2,469 | Knockout | Gbp3 | cell viability | Immortal mouse chromaffin cells | Gene: Gbp3 (guanylate binding protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, adhesion of symbiont to host, cellular response to interferon-beta, cellular response to lipopolysaccharide, cellular response to tumor necrosis ... |
Does Knockout of Neto2 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 163 | Knockout | Neto2 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Neto2 (neuropilin (NRP) and tolloid (TLL)-like 2)
Type: protein-coding
Summary: Enables ionotropic glutamate receptor binding activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of neurotransmitter receptor localizatio... |
Does Knockout of Rps19bp1 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Rps19bp1 | response to bacteria | renal medulla cell line | Gene: Rps19bp1 (ribosomal protein S19 binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, ribosomal small subunit biogenesis; MF: enzyme binding, protein binding; CC: cytosol, nucleolus, nucleoplasm, nucleus, small-subunit processome
... |
Does Knockout of Fank1 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Fank1 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Fank1 (fibronectin type 3 and ankyrin repeat domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of apoptotic process, positive regulation of DNA-binding transcription factor activity, positive regulation of DNA-templated transcription, po... |
Does Knockout of Upk3a in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Upk3a | cell cycle progression | breast epithelium | Gene: Upk3a (uroplakin 3A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell morphogenesis, epithelial cell differentiation, kidney development, potassium ion homeostasis, sodium ion homeostasis, urea transport, urinary bladder development, water transport; CC: apical ... |
Does Knockout of Defb48 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Defb48 | phagocytosis | macrophage | Gene: Defb48 (defensin beta 48)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, defense response, defense response to bacterium, positive chemotaxis; MF: CCR6 chemokine receptor binding, chemoattractant activity; CC: extracellular region, extracellular sp... |
Does Knockout of Pou2f2 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Pou2f2 | phagocytosis | macrophage | Gene: Pou2f2 (POU domain, class 2, transcription factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell maturation, cellular response to virus, mature B cell differentiation, positive regulation of DNA-templated transcription, positive regulation of interleukin-6 ... |
Does Knockout of Gpr15 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Gpr15 | cell proliferation | Colonic Cancer Cell Line | Gene: Gpr15 (G protein-coupled receptor 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, T cell migration, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, angiogenesis, signal transduction, symbio... |
Does Knockout of Fut4 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Fut4 | cell proliferation | Colonic Cancer Cell Line | Gene: Fut4 (fucosyltransferase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Lewis x epitope biosynthetic process, fucosylation, glycosphingolipid biosynthetic process, inflammatory response, lymphocyte migration into lymph node, oligosaccharide metabolic process, po... |
Does Knockout of Shq1 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Shq1 | cell proliferation | Embryonic Stem Cell Line | Gene: Shq1 (SHQ1 homolog (S. cerevisiae))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: box H/ACA snoRNP assembly, positive regulation of TORC1 signaling, protein-RNA complex assembly, regulation of androgen receptor signaling pathway; CC: cytoplasm, cytosol, nucleoplas... |
Does Knockout of Vsig8 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Vsig8 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Vsig8 (V-set and immunoglobulin domain containing 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q6P3A4
Entrez ID: 240916 |
Does Knockout of Mdn1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Mdn1 | protein/peptide distribution | myoblast cell line | Gene: Mdn1 (midasin AAA ATPase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit assembly, ribosome biogenesis; MF: ATP binding, ATP hydrolysis activity, molecular_function, nucleotide binding; CC: cytosol, intermediate filament cytoskeleton, nucl... |
Does Knockout of Rsl24d1 in Regulatory T cell causally result in cell proliferation? | 1 | 1,483 | Knockout | Rsl24d1 | cell proliferation | Regulatory T cell | Gene: Rsl24d1 (ribosomal L24 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ribosomal large subunit biogenesis, ribosome biogenesis; CC: nucleolus, nucleoplasm, nucleus
Pathways: Coronavirus disease - COVID-19 - Mus musculus (mouse), Ribosom... |
Does Knockout of Rab21 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 2,170 | Knockout | Rab21 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Rab21 (RAB21, member RAS oncogene family)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rab protein signal transduction, anterograde axonal transport, intracellular protein transport, positive regulation of dendrite morphogenesis, positive regulation of early endo... |
Does Knockout of Erv3 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Erv3 | protein/peptide distribution | myoblast cell line | Gene: Erv3 (endogenous retroviral sequence 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9DAX3
Entrez ID: 71995 |
Does Knockout of Nr1d1 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,682 | Knockout | Nr1d1 | protein/peptide distribution | myoblast cell line | Gene: Nr1d1 (nuclear receptor subfamily 1, group D, member 1)
Type: protein-coding
Summary: This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock... |
Does Knockout of Rps6ka6 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Rps6ka6 | cell proliferation | Colonic Cancer Cell Line | Gene: Rps6ka6 (ribosomal protein S6 kinase polypeptide 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, TORC1 signaling, intracellular signal transduction, negative regulation of ERK1 and ERK2 cascade, nega... |
Does Knockout of Mageb1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Mageb1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Mageb1 (MAGE family member B1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q60761
Entrez ID: 17145 |
Does Knockout of Mrpl18 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,440 | Knockout | Mrpl18 | protein/peptide accumulation | Embryonic Cell Line | Gene: Mrpl18 (mitochondrial ribosomal protein L18)
Type: protein-coding
Summary: Predicted to enable 5S rRNA binding activity. Predicted to be involved in rRNA import into mitochondrion. Located in mitochondrion. Is expressed in several structures, including brain; connective tissue; early conceptus; ge... |
Does Knockout of Phrf1 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Phrf1 | cell proliferation | Embryonic Stem Cell Line | Gene: Phrf1 (PHD and ring finger domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mRNA processing, transcription by RNA polymerase II; MF: RNA polymerase binding, metal ion binding, protein domain specific binding, zinc ion binding
Pathways:
U... |
Does Knockout of Usp9y in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Usp9y | cell proliferation | Mouse kidney carcinoma cell | Gene: Usp9y (ubiquitin specific peptidase 9, Y chromosome)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, protein deubiquitination, protein ubiquitination, proteolysis, regulation of protein stability; MF: cysteine-type deubiquitinase activity, cysteine-t... |
Does Knockout of Hnrnpm in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Hnrnpm | protein/peptide accumulation | Microglial Cell Line | Gene: Hnrnpm (heterogeneous nuclear ribonucleoprotein M)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, mRNA processing, positive regulation of protein import, positive regulation of protein localization to nucleu... |
Does Knockout of Pitpna in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Pitpna | cell proliferation | Melanoma Cell Line | Gene: Pitpna (phosphatidylinositol transfer protein, alpha)
Type: protein-coding
Summary: This gene encodes a member of a family of lipid-binding proteins that transfer molecules of phosphatidylinositol or phosphatidylcholine between membrane surfaces. The protein is implicated in phospholipase C signal... |
Does Knockout of Klc1 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Klc1 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Klc1 (kinesin light chain 1)
Type: protein-coding
Summary: Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains b... |
Does Knockout of Gm11627 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,285 | Knockout | Gm11627 | cell proliferation | Mouse kidney carcinoma cell | Gene: Gm11627 (predicted gene 11627)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 100040792 |
Does Knockout of Camsap3 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,282 | Knockout | Camsap3 | cell proliferation | Melanoma Cell Line | Gene: Camsap3 (calmodulin regulated spectrin-associated protein family, member 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cilium movement, cytoplasmic microtubule organization, embryo development ending in birth or egg hatching, epith... |
Does Knockout of Zcchc3 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Zcchc3 | cell proliferation | Mouse kidney carcinoma cell | Gene: Zcchc3 (zinc finger, CCHC domain containing 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of innate immune response, cellular response to exogenous dsRNA, defense response to virus, detection of virus, immune system process, innate immune response, p... |
Does Knockout of Lrig3 in Melanoma Cell Line causally result in tumorigenicity? | 0 | 2,187 | Knockout | Lrig3 | tumorigenicity | Melanoma Cell Line | Gene: Lrig3 (leucine-rich repeats and immunoglobulin-like domains 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: otolith morphogenesis; CC: cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, plasma membrane
Pathways:
UniProt: Q6P1C6
... |
Does Knockout of Dbndd2 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Dbndd2 | protein/peptide accumulation | Regulatory T cell | Gene: Dbndd2 (dysbindin domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ERK1 and ERK2 cascade, apoptotic process, monoatomic ion homeostasis, negative regulation of protein kinase activity, neurogenesis, neuron projection development, regulation of si... |
Does Knockout of Stk35 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Stk35 | phagocytosis | macrophage | Gene: Stk35 (serine/threonine kinase 35)
Type: protein-coding
Summary: Predicted to enable protein kinase activity. Predicted to be involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of G2/MI transition of meiotic cell cycle. Predicted to be located in nucle... |
Does Knockout of Ankrd45 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Ankrd45 | cell proliferation | Embryonic Stem Cell Line | Gene: Ankrd45 (ankyrin repeat domain 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell population proliferation; CC: Flemming body, centrosome, cleavage furrow, cytoplasm, cytosol, midbody, plasma membrane
Pathways:
UniProt: Q810N6
Entrez... |
Does Knockout of Vsx2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Vsx2 | cell proliferation | Colonic Cancer Cell Line | Gene: Vsx2 (visual system homeobox 2)
Type: protein-coding
Summary: This gene encodes a member of the Vsx (visual system homeobox) family which belongs to the larger PRD homeobox class. The encoded protein is required for eye organogenesis and controls retinal development. Disruption of this gene is ass... |
Does Knockout of Akap1 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,264 | Knockout | Akap1 | cell proliferation | Colonic Cancer Cell Line | Gene: Akap1 (A kinase anchor protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antiviral innate immune response, apoptotic process, negative regulation of cell growth involved in cardiac muscle cell development, negative regulation of dephosphorylation, negative ... |
Does Knockout of Plxnb3 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Plxnb3 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Plxnb3 (plexin B3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell chemotaxis, homophilic cell adhesion via plasma membrane adhesion molecules, negative regulation of GTPase activity, negative regulation of cell adhesion, negative regulation of cell migration, ... |
Does Knockout of Tcl1b3 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Tcl1b3 | protein/peptide accumulation | Microglial Cell Line | Gene: Tcl1b3 (T cell leukemia/lymphoma 1B, 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intracellular signal transduction; MF: protein kinase binding, protein serine/threonine kinase activator activity
Pathways:
UniProt: P56842
Entrez ID: ... |
Does Knockout of Atg12 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,680 | Knockout | Atg12 | protein/peptide distribution | myoblast cell line | Gene: Atg12 (autophagy related 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, autophagosome maturation, autophagy, autophagy of mitochondrion, glycophagy, macroautophagy, negative regulation of defense response to virus, negative regulation of... |
Does Knockout of Runx1t1 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Runx1t1 | protein/peptide accumulation | Embryonic Cell Line | Gene: Runx1t1 (RUNX1 translocation partner 1)
Type: protein-coding
Summary: Enables identical protein binding activity. Involved in negative regulation of fat cell differentiation. Acts upstream of or within fat cell differentiation and regulation of DNA-templated transcription. Located in nucleus. Is e... |
Does Knockout of Camta2 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Camta2 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Camta2 (calmodulin binding transcription activator 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle hypertrophy in response to stress, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II; MF: D... |
Does Knockout of Rps16 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Rps16 | protein/peptide accumulation | Embryonic Cell Line | Gene: Rps16 (ribosomal protein S16)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to leukemia inhibitory factor, cytoplasmic translation, maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), rRNA processing, ribosom... |
Does Knockout of Gm266 in breast epithelium causally result in cell cycle progression? | 0 | 1,469 | Knockout | Gm266 | cell cycle progression | breast epithelium | Gene: Gm266 (predicted gene 266)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rap protein signal transduction, negative regulation of cell migration, signal transduction; MF: GDP binding, GTP binding, GTPase activity; CC: endomembrane system, membrane, plasma membrane
... |
Does Knockout of Gba2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,171 | Knockout | Gba2 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Gba2 (glucosidase beta 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bile acid metabolic process, carbohydrate metabolic process, central nervous system development, central nervous system neuron development, cholesterol metabolic process, glucosylceramide cata... |
Does Knockout of Il22 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Il22 | protein/peptide distribution | myoblast cell line | Gene: Il22 (interleukin 22)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of cytokine production involved in inflammatory response, negative regulation of inflammatory response, positive regulation of inflammatory response, positive regulation of tra... |
Does Knockout of Prlr in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Prlr | phagocytosis | macrophage | Gene: Prlr (prolactin receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell surface receptor signaling pathway via JAK-STAT, cellular response to granulocyte macrophage colony-stimulating factor stimulus, cytokine-mediated signaling pathway, lactation, mammary gl... |
Does Knockout of Zfr2 in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,275 | Knockout | Zfr2 | cell proliferation | Colonic Cancer Cell Line | Gene: Zfr2 (zinc finger RNA binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: double-stranded RNA binding, molecular_function, nucleic acid binding, single-stranded RNA binding, zinc ion binding
Pathways:
UniProt: F6VRB4, E9Q5M4, D3YXQ2... |
Does Knockout of Sox2 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Sox2 | protein/peptide accumulation | Embryonic Cell Line | Gene: Sox2 (SRY (sex determining region Y)-box 2)
Type: protein-coding
Summary: This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is re... |
Does Knockout of Gabrd in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Gabrd | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Gabrd (gamma-aminobutyric acid (GABA) A receptor, subunit delta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell-cell signaling, chemical synaptic transmission, chloride transmembrane transport, chloride transport, gamma-aminobutyric acid signaling pathway, mon... |
Does Knockout of Iqcf3 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Iqcf3 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Iqcf3 (IQ motif containing F3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9D498
Entrez ID: 68265 |
Does Knockout of Wdr26 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Wdr26 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Wdr26 (WD repeat domain 26)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: GID complex, cytoplasm, cytosol, mitochondrion, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways: Aerobic respiration and respiratory electron transport, Metabolism, Pyruvate... |
Does Knockout of Fundc1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Fundc1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Fundc1 (FUN14 domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagy, autophagy of mitochondrion, mitochondrial fusion, mitophagy, response to hypoxia; CC: membrane, mitochondrial outer membrane, mitochondrion
Pathways: Autophagy, Ma... |
Does Knockout of Tnnt3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Tnnt3 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Tnnt3 (troponin T3, skeletal, fast)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of muscle contraction, regulation of striated muscle contraction, sarcomere organization, skeletal muscle contraction; MF: actin binding, calcium-dependent protein binding... |
Does Knockout of Eif5a2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 1,664 | Knockout | Eif5a2 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Eif5a2 (eukaryotic translation initiation factor 5A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of translational elongation, positive regulation of translational termination, translation, translational elongation; MF: RNA binding, ribosome ... |
Does Knockout of Tjap1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Tjap1 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Tjap1 (tight junction associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization; CC: Golgi apparatus, anchoring junction, bicellular tight junction, cytoplasm, endosome, membrane, plasma membrane, trans-Golgi network
Pathways:... |
Does Knockout of Sptssb in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Sptssb | cell proliferation | Mouse kidney carcinoma cell | Gene: Sptssb (serine palmitoyltransferase, small subunit B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide biosynthetic process, endoplasmic reticulum organization, lipid metabolic process, sphingolipid biosynthetic process, sphingolipid metabolic process, sphin... |
Does Knockout of Klb in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Klb | cell proliferation | Regulatory T cell | Gene: Klb (klotho beta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, fibroblast growth factor receptor signaling pathway, positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway, positive regulation o... |
Does Knockout of Arhgap26 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 2,403 | Knockout | Arhgap26 | protein/peptide accumulation | Embryonic Cell Line | Gene: Arhgap26 (Rho GTPase activating protein 26)
Type: protein-coding
Summary: Predicted to enable GTPase activator activity; phospholipid binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in mitophagy. Predicted to be located in cytosol and endosome membrane. Predi... |
Does Knockout of Rbm38 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Rbm38 | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Rbm38 (RNA binding motif protein 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA stabilization, DNA damage response, signal transduction by p53 class mediator, RNA splicing, cell differentiation, mRNA processing, negative regulation of cell ... |
Does Knockout of Pacsin3 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Pacsin3 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Pacsin3 (protein kinase C and casein kinase substrate in neurons 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cytoskeleton organization, endocytosis, negative regulation of calcium ion transport, negative regulation of endocytosis, plasma membrane tubulation, ... |
Does Knockout of Defb38 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Defb38 | cell proliferation | Melanoma Cell Line | Gene: Defb38 (defensin beta 38)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, defense response to bacterium, innate immune response in mucosa, response to bacteri... |
Does Knockout of Kcne4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Kcne4 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Kcne4 (potassium voltage-gated channel, Isk-related subfamily, gene 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: membrane repolarization during action potential, membrane repolarization during ventricular cardiac muscle cell action potential, monoatomic ion tr... |
Does Knockout of Prkcsh in Colonic Cancer Cell Line causally result in tumorigenicity? | 0 | 2,180 | Knockout | Prkcsh | tumorigenicity | Colonic Cancer Cell Line | Gene: Prkcsh (protein kinase C substrate 80K-H)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: N-glycan processing, in utero embryonic development, liver development, negative regulation of neuron projection development, nitrogen cycle metabolic process; MF: RNA binding,... |
Does Knockout of Prom2 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Prom2 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Prom2 (prominin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of caveolin-mediated endocytosis, negative regulation of pinocytosis, positive regulation of cell projection organization; MF: cholesterol binding; CC: apical plasma membrane, bas... |
Does Knockout of Cilp in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Cilp | response to virus | Microglial Cell Line | Gene: Cilp (cartilage intermediate layer protein, nucleotide pyrophosphohydrolase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of SMAD protein signal transduction, negative regulation of gene expression, negative regulation of insulin-like growth f... |
Does Knockout of Snapc4 in Colonic Cancer Cell Line causally result in cell proliferation? | 1 | 1,264 | Knockout | Snapc4 | cell proliferation | Colonic Cancer Cell Line | Gene: Snapc4 (small nuclear RNA activating complex, polypeptide 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: snRNA transcription by RNA polymerase II, snRNA transcription by RNA polymerase III; MF: DNA binding, RNA polymerase II cis-regulatory region sequence-specif... |
Does Knockout of Arhgap35 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Arhgap35 | protein/peptide distribution | myoblast cell line | Gene: Arhgap35 (Rho GTPase activating protein 35)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Rho protein signal transduction, axon guidance, axonal fasciculation, camera-type eye development, cell migration, central nervous system neuron axonogenesis, establishment o... |
Does Knockout of Zscan30 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,283 | Knockout | Zscan30 | cell proliferation | Mouse kidney carcinoma cell | Gene: Zscan30 (zinc finger and SCAN domain containing 30)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q149X8
Entrez ID: 328918 |
Does Knockout of Stx5a in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Stx5a | cell proliferation | Mouse kidney carcinoma cell | Gene: Stx5a (syntaxin 5A)
Type: protein-coding
Summary: Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and regulation of Golgi organization. Predicted to act upstream of or within... |
Does Knockout of Prdm12 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,398 | Knockout | Prdm12 | protein/peptide accumulation | Microglial Cell Line | Gene: Prdm12 (PR domain containing 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: detection of temperature stimulus involved in sensory perception of pain, negative regulation of transcription by RNA polymerase II, neurogenesis, neuron fate specification, neuron proj... |
Does Knockout of Peg3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,262 | Knockout | Peg3 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Peg3 (paternally expressed 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic process, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, regulation of gene expression, regulation of transc... |
Does Knockout of Hsd17b13 in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Hsd17b13 | response to bacteria | macrophage | Gene: Hsd17b13 (hydroxysteroid (17-beta) dehydrogenase 13)
Type: protein-coding
Summary: Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and steroid dehydrogenase activity. Predicted to be involved in lipid metabolic process. Predicted to act ups... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.