prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Riok3 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Riok3
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Riok3 (RIO kinase 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to dsDNA, cellular response to dsRNA, cellular response to virus, defense response to virus, immune system process, innate immune response, maturation of SSU-rRNA, negative regulation of MDA-5 signaling pathway, negative regulation of canonical NF-kappaB signal transduction, negative regulation of protein-containing complex assembly, positive regulation of innate immune response, positive regulation of interferon-beta production, ribosome biogenesis; MF: ATP binding, caspase binding, catalytic activity, kinase activity, metal ion binding, nucleotide binding, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9DBU3
Entrez ID: 66878
|
Does Knockout of Sh2d1a in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Sh2d1a
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Sh2d1a (SH2 domain containing 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: adaptive immune response, cell-cell signaling, cellular defense response, humoral immune response, immune system process, innate immune response, natural killer cell activation, negative regulation of T cell receptor signaling pathway, positive regulation of natural killer cell mediated cytotoxicity, regulation of immune response; MF: protein binding, protein-macromolecule adaptor activity; CC: cytoplasm
Pathways: Natural killer cell mediated cytotoxicity - Mus musculus (mouse)
UniProt: O88890
Entrez ID: 20400
|
Does Knockout of Wdr35 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Wdr35
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Wdr35 (WD repeat domain 35)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection organization, cellular response to leukemia inhibitory factor, cellular response to tumor necrosis factor, cilium assembly, intraciliary retrograde transport, intraciliary transport, negative regulation of gene expression, negative regulation of nitric oxide biosynthetic process, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of release of cytochrome c from mitochondria, positive regulation of vasoconstriction, protein localization to cilium; CC: axoneme, cell projection, centrosome, ciliary basal body, cilium, cytoplasm, cytoskeleton, intraciliary transport particle A
Pathways: Cilium Assembly, Hedgehog 'off' state, Intraflagellar transport, Organelle biogenesis and maintenance, Signal Transduction, Signaling by Hedgehog
UniProt: Q8BND3
Entrez ID: 74682
|
Does Knockout of Mir6950 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Mir6950
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Mir6950 (microRNA 6950)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 102465573
|
Does Knockout of Myh2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,178
|
Knockout
|
Myh2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Myh2 (myosin, heavy polypeptide 2, skeletal muscle, adult)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: muscle contraction, response to muscle activity; MF: ATP binding, actin binding, actin filament binding, cytoskeletal motor activity, microfilament motor activity, nucleotide binding; CC: A band, actomyosin contractile ring, cell-cell junction, cytoplasm, muscle myosin complex, myofibril, myosin II complex, myosin complex, myosin filament, protein-containing complex
Pathways: Fcgamma receptor (FCGR) dependent phagocytosis, Immune System, Innate Immune System, Regulation of actin dynamics for phagocytic cup formation
UniProt: G3UW82
Entrez ID: 17882
|
Does Knockout of Rft1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Rft1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rft1 (RFT1 homolog)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: dolichol-linked oligosaccharide biosynthetic process, glycolipid translocation, protein N-linked glycosylation; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways:
UniProt: Q8C3B8
Entrez ID: 328370
|
Does Knockout of Mdm4 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,663
|
Knockout
|
Mdm4
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Mdm4 (transformed mouse 3T3 cell double minute 4)
Type: protein-coding
Summary: This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Gene Ontology: BP: DNA damage response, signal transduction by p53 class mediator, atrial septum development, atrioventricular valve morphogenesis, endocardial cushion morphogenesis, heart valve development, negative regulation of DNA-templated transcription, negative regulation of apoptotic process, negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, negative regulation of protein catabolic process, negative regulation of transcription by RNA polymerase II, positive regulation of cell population proliferation, protein ubiquitination, protein-containing complex assembly, regulation of cell cycle, regulation of cell population proliferation, regulation of heart rate, ventricular septum development; MF: enzyme binding, metal ion binding, protein binding, ubiquitin-protein transferase activity, zinc ion binding; CC: nucleoplasm, nucleus, transcription repressor complex
Pathways: Cell Cycle, Cell Cycle Checkpoints, Cellular Senescence, Cellular responses to stimuli, Cellular responses to stress, Deubiquitination, G1/S DNA Damage Checkpoints, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of proteins, MicroRNAs in cancer - Mus musculus (mouse), Oncogene Induced Senescence, Oxidative Stress Induced Senescence, Post-translational protein modification, RNA Polymerase II Transcription, Regulation of TP53 Activity, Regulation of TP53 Activity through Methylation, Regulation of TP53 Activity through Phosphorylation, Regulation of TP53 Degradation, Regulation of TP53 Expression and Degradation, Stabilization of p53, Transcriptional Regulation by TP53, Ub-specific processing proteases, p53 signaling pathway - Mus musculus (mouse), p53-Dependent G1 DNA Damage Response, p53-Dependent G1/S DNA damage checkpoint
UniProt: O35618
Entrez ID: 17248
|
Does Knockout of Cdkn3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Cdkn3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cdkn3 (cyclin dependent kinase inhibitor 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, regulation of cell cycle; MF: hydrolase activity, phosphoprotein phosphatase activity, protein binding, protein serine/threonine phosphatase activity, protein tyrosine phosphatase activity; CC: cytoplasm, cytosol, nucleus, perinuclear region of cytoplasm
Pathways:
UniProt: Q810P3
Entrez ID: 72391
|
Does Knockout of Pcx in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Pcx
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pcx (pyruvate carboxylase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NADP+ metabolic process, gluconeogenesis, glyceraldehyde-3-phosphate biosynthetic process, host-mediated activation of viral process, lipid metabolic process, negative regulation of gene expression, positive regulation of phospholipid biosynthetic process, viral RNA genome packaging, viral release from host cell; MF: ATP binding, biotin binding, catalytic activity, identical protein binding, ligase activity, metal ion binding, nucleotide binding, pyruvate carboxylase activity; CC: cytoplasm, cytosol, mitochondrial inner membrane, mitochondrial matrix, mitochondrion
Pathways: Citrate cycle (TCA cycle) - Mus musculus (mouse), Pyruvate metabolism - Mus musculus (mouse), aspartate biosynthesis
UniProt: Q8BP54, G5E8R3, Q3UFS6, E9QPD7, A0A286YCC5, A0A494B951, A0A494B912
Entrez ID: 18563
|
Does Knockout of Foxd1 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Foxd1
|
phagocytosis
|
macrophage
|
Gene: Foxd1 (forkhead box D1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: anatomical structure morphogenesis, axon guidance, branching involved in ureteric bud morphogenesis, canonical Wnt signaling pathway, cell differentiation, dichotomous subdivision of terminal units involved in ureteric bud branching, kidney development, luteinizing hormone secretion, metanephric capsule development, metanephric capsule specification, metanephric nephron development, negative regulation of DNA-templated transcription, nephrogenic mesenchyme development, pattern specification involved in metanephros development, positive regulation of BMP signaling pathway, positive regulation of gene expression, positive regulation of kidney development, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA binding, bending, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding
Pathways:
UniProt: Q61345
Entrez ID: 15229
|
Does Knockout of Loxhd1 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Loxhd1
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Loxhd1 (lipoxygenase homology domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: sensory perception of sound; CC: cell projection, stereocilium
Pathways:
UniProt: C8YR32
Entrez ID: 240411
|
Does Knockout of Blvra in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Blvra
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Blvra (biliverdin reductase A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: MAPK cascade, apoptotic DNA fragmentation, canonical NF-kappaB signal transduction, chemotaxis, complement component C5a signaling pathway, ear development, fatty acid metabolic process, gene expression, glucose homeostasis, glycogen metabolic process, heme catabolic process, immune response, inflammatory response, insulin metabolic process, insulin receptor signaling pathway, lipid metabolic process, lipid oxidation, negative regulation of apoptotic process, phosphatidylinositol 3-kinase/protein kinase B signal transduction, pigment metabolic process, reactive oxygen species biosynthetic process, response to cyclosporin A, response to food, response to lipopolysaccharide, response to oxidative stress, sensory perception of itch, triglyceride metabolic process; MF: RNA polymerase II cis-regulatory region sequence-specific DNA binding, biliberdin reductase (NADH) activity, biliverdin reductase (NADPH) activity, biliverdin reductase [NAD(P)H] activity, metal ion binding, nucleotide binding, oxidoreductase activity, protein serine/threonine kinase activity, zinc ion binding; CC: cell surface, cytoplasm, cytosol, nucleus
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Heme degradation, Metabolism, Metabolism of porphyrins, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), heme degradation
UniProt: Q9CY64
Entrez ID: 109778
|
Does Knockout of Mad2l1bp in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Mad2l1bp
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Mad2l1bp (MAD2L1 binding protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: deactivation of mitotic spindle assembly checkpoint, mitotic spindle assembly checkpoint signaling, regulation of exit from mitosis; CC: cytoplasm, cytoskeleton, nuclear membrane, nucleolus, nucleoplasm, nucleus, spindle
Pathways:
UniProt: Q9DCX1
Entrez ID: 66591
|
Does Knockout of Hmox2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Hmox2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Hmox2 (heme oxygenase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to iron ion starvation, heme catabolic process, heme oxidation, response to hypoxia, response to oxidative stress; MF: heme binding, heme oxygenase (decyclizing) activity, metal ion binding, oxidoreductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Cellular response to chemical stress, Cellular responses to stimuli, Cellular responses to stress, Cytoprotection by HMOX1, Heme degradation, Immune System, Innate Immune System, Iron uptake and transport, Metabolism, Metabolism of porphyrins, Mineral absorption - Mus musculus (mouse), Neutrophil degranulation, Porphyrin and chlorophyll metabolism - Mus musculus (mouse), RHO GTPase cycle, RHOA GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport of small molecules, heme degradation
UniProt: O70252
Entrez ID: 15369
|
Does Knockout of Hvcn1 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Hvcn1
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Hvcn1 (hydrogen voltage-gated channel 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to pH, cellular response to zinc ion, immune system process, innate immune response, monoatomic ion transmembrane transport, monoatomic ion transport, positive regulation of superoxide anion generation, proton transmembrane transport, regulation of acrosome reaction, regulation of intracellular pH, regulation of reactive oxygen species biosynthetic process, response to pH, response to zinc ion, transmembrane transport; MF: identical protein binding, monoatomic ion channel activity, protein homodimerization activity, voltage-gated monoatomic cation channel activity, voltage-gated proton channel activity; CC: apical plasma membrane, cell projection, cilium, cytoplasmic vesicle, membrane, monoatomic ion channel complex, motile cilium, phagocytic vesicle membrane, plasma membrane, sperm flagellum
Pathways: Fertilization, Immune System, Innate Immune System, Neutrophil degranulation, ROS and RNS production in phagocytes, Reproduction, Sperm Motility And Taxes
UniProt: Q3U2S8
Entrez ID: 74096
|
Does Knockout of Ttll8 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 2,477
|
Knockout
|
Ttll8
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Ttll8 (tubulin tyrosine ligase-like family, member 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axoneme assembly, cilium assembly, flagellated sperm motility, protein polyglycylation, spermatogenesis; MF: ATP binding, ligase activity, metal ion binding, nucleotide binding, protein-glycine ligase activity, protein-glycine ligase activity, initiating; CC: axoneme, cell projection, cilium, cytoplasm, cytoskeleton, microtubule, microtubule cytoskeleton, motile cilium, sperm flagellum
Pathways: Carboxyterminal post-translational modifications of tubulin, Metabolism of proteins, Post-translational protein modification
UniProt: A4Q9F1
Entrez ID: 239591
|
Does Knockout of Ndufa12 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,282
|
Knockout
|
Ndufa12
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ndufa12 (NADH:ubiquinone oxidoreductase subunit A12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aerobic respiration, mitochondrial ATP synthesis coupled electron transport, proton motive force-driven mitochondrial ATP synthesis; CC: membrane, mitochondrial inner membrane, mitochondrion, respiratory chain complex I
Pathways: Aerobic respiration and respiratory electron transport, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Complex I biogenesis, Diabetic cardiomyopathy - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), Metabolism, NADH to cytochrome <i>bd</i> oxidase electron transfer I, NADH to cytochrome <i>bo</i> oxidase electron transfer I, Non-alcoholic fatty liver disease - Mus musculus (mouse), Oxidative phosphorylation - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Respiratory electron transport, Retrograde endocannabinoid signaling - Mus musculus (mouse), Thermogenesis - Mus musculus (mouse), aerobic respiration -- electron donor II
UniProt: Q7TMF3
Entrez ID: 66414
|
Does Knockout of Cntd1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Cntd1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cntd1 (cyclin N-terminal domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: meiotic cell cycle, reciprocal meiotic recombination, regulation of meiotic cell cycle, spermatogenesis; CC: chromosome, cytoplasm, nucleus, site of double-strand break
Pathways:
UniProt: Q9D995
Entrez ID: 68107
|
Does Knockout of Dhx36 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 1
| 161
|
Knockout
|
Dhx36
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Dhx36 (DEAH-box helicase 36)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 3'-UTR-mediated mRNA destabilization, cell differentiation, cellular response to UV, cellular response to arsenite ion, cellular response to heat, defense response to virus, immune system process, innate immune response, negative regulation of translation, ossification, positive regulation of canonical NF-kappaB signal transduction, positive regulation of cardioblast differentiation, positive regulation of cytoplasmic translation, positive regulation of dendritic spine morphogenesis, positive regulation of gene expression, positive regulation of hematopoietic progenitor cell differentiation, positive regulation of interferon-alpha production, positive regulation of intracellular mRNA localization, positive regulation of mRNA 3'-end processing, positive regulation of myeloid dendritic cell cytokine production, positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, positive regulation of telomere maintenance, positive regulation of telomere maintenance via telomere lengthening, positive regulation of transcription by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, regulation of embryonic development, regulation of mRNA stability, regulation of transcription by RNA polymerase III, regulation of translation, response to exogenous dsRNA, response to virus, spermatogenesis, telomerase RNA stabilization; MF: ATP binding, ATP hydrolysis activity, ATP-dependent activity, acting on DNA, DNA binding, DNA helicase activity, G-quadruplex DNA binding, G-quadruplex RNA binding, RNA binding, RNA helicase activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, catalytic activity, acting on a nucleic acid, double-stranded RNA binding, helicase activity, histone deacetylase binding, hydrolase activity, mRNA 3'-UTR AU-rich region binding, mRNA 3'-UTR binding, mRNA 5'-UTR binding, magnesium ion binding, metal ion binding, nucleic acid binding, nucleotide binding, pre-miRNA binding, protein binding, single-stranded DNA binding, telomerase RNA binding, transcription cis-regulatory region binding; CC: axon, cell projection, chromosome, chromosome, telomeric region, cytoplasm, cytoplasmic stress granule, cytosol, dendrite, mitochondrion, nuclear speck, nucleoplasm, nucleus, perikaryon
Pathways: Cytosolic sensors of pathogen-associated DNA , DEx/H-box helicases activate type I IFN and inflammatory cytokines production , Immune System, Innate Immune System, RNA degradation - Mus musculus (mouse)
UniProt: Q8VHK9
Entrez ID: 72162
|
Does Knockout of Nmral1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,262
|
Knockout
|
Nmral1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Nmral1 (NmrA-like family domain containing 1)
Type: protein-coding
Summary: Predicted to enable identical protein binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; genitourinary system; gut; and lung. Orthologous to human NMRAL1 (NmrA like redox sensor 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: CC: cytoplasm, nucleoplasm, nucleus, perinuclear region of cytoplasm
Pathways: Metabolism, Metabolism of amino acids and derivatives, Urea cycle
UniProt: Q8K2T1
Entrez ID: 67824
|
Does Knockout of Krt16 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,273
|
Knockout
|
Krt16
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Krt16 (keratin 16)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin and acts as an innate immune system effector, promoting the inflammatory response upon breach of the skin barrier. Defects in this gene are a cause of pachyonychia congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].
Gene Ontology: BP: establishment of skin barrier, hair cycle, immune system process, inflammatory response, innate immune response, intermediate filament cytoskeleton organization, intermediate filament organization, keratinization, keratinocyte differentiation, keratinocyte migration, morphogenesis of an epithelium, negative regulation of cell migration; MF: protein binding, structural constituent of cytoskeleton, structural constituent of skin epidermis, structural molecule activity; CC: cornified envelope, cytoskeleton, intermediate filament, keratin filament
Pathways: Developmental Biology, Estrogen signaling pathway - Mus musculus (mouse), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Q9Z2K1
Entrez ID: 16666
|
Does Knockout of Nudcd2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Nudcd2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Nudcd2 (NudC domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, chromosome, chromosome, centromeric region, cytoplasm, cytoskeleton, cytosol, intercellular bridge, kinetochore, microtubule cytoskeleton, mitotic spindle, spindle pole
Pathways:
UniProt: Q9CQ48
Entrez ID: 52653
|
Does Knockout of Vmn2r110 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Vmn2r110
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Vmn2r110 (vomeronasal 2, receptor 110)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, signal transduction; MF: G protein-coupled receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: A0A3B2W3V0, E9PWD5, A0A3B2WCK1
Entrez ID: 224582
|
Does Knockout of Abhd16a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Abhd16a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Abhd16a (abhydrolase domain containing 16A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: lipid metabolic process, monoacylglycerol catabolic process, phosphatidylserine catabolic process, prostaglandin catabolic process; MF: hydrolase activity, monoacylglycerol lipase activity, phospholipase activity
Pathways:
UniProt: Q9Z1Q2
Entrez ID: 193742
|
Does Knockout of Polg in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Polg
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Polg (polymerase (DNA directed), gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA biosynthetic process, DNA metabolic process, DNA replication, DNA replication proofreading, DNA-templated DNA replication, base-excision repair, determination of adult lifespan, mitochondrial DNA replication; MF: 3'-5' exonuclease activity, 5'-deoxyribose-5-phosphate lyase activity, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, catalytic activity, acting on a nucleic acid, chromatin binding, exonuclease activity, hydrolase activity, lyase activity, metal ion binding, nucleotidyltransferase activity, protease binding, protein binding, single-stranded DNA 3'-5' DNA exonuclease activity, transferase activity; CC: gamma DNA polymerase complex, mitochondrial chromosome, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, protein-containing complex, terminal bouton
Pathways:
UniProt: Q3UG70, Q75WC0, Q3UZX3, A0A0J9YTR4, A0A0J9YU70, A0A0J9YUA1, F7BP45, A0A0J9YU03, F6YLN2, D6RIP1, A0A0J9YV64, A0A0J9YTZ6
Entrez ID: 18975
|
Does Knockout of Tnks1bp1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Tnks1bp1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Tnks1bp1 (tankyrase 1 binding protein 1)
Type: protein-coding
Summary: Predicted to enable ankyrin repeat binding activity and enzyme binding activity. Predicted to be involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Predicted to be located in adherens junction; cytoplasm; and plasma membrane. Predicted to be part of CCR4-NOT complex. Predicted to be active in heterochromatin and nucleus. Orthologous to human TNKS1BP1 (tankyrase 1 binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: cellular response to ionizing radiation, double-strand break repair; MF: ankyrin repeat binding, enzyme binding, protein serine/threonine kinase activator activity, protein-containing complex binding; CC: CCR4-NOT complex, adherens junction, chromosome, cytoplasm, cytoskeleton, cytosol, heterochromatin, nucleus
Pathways: Deadenylation of mRNA, Deadenylation-dependent mRNA decay, Gene expression (Transcription), Generic Transcription Pathway, Metabolism of RNA, RNA Polymerase II Transcription, TP53 Regulates Transcription of Cell Cycle Genes, TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain, Transcriptional Regulation by TP53
UniProt: P58871
Entrez ID: 228140
|
Does Knockout of Atf6 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Atf6
|
response to bacteria
|
renal medulla cell line
|
Gene: Atf6 (activating transcription factor 6)
Type: protein-coding
Summary: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and protein heterodimerization activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; eye; liver; long bone; and tooth. Used to study achromatopsia 7. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: endoplasmic reticulum unfolded protein response, eye development, positive regulation of ATF6-mediated unfolded protein response, positive regulation of apoptotic process, positive regulation of autophagy, positive regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, response to endoplasmic reticulum stress, response to unfolded protein, visual perception; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, enzyme binding, identical protein binding, protein binding, protein heterodimerization activity, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, ubiquitin protein ligase binding; CC: Golgi apparatus, Golgi membrane, RNA polymerase II transcription regulator complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleus
Pathways: ATF6 (ATF6-alpha) activates chaperones, Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Cellular responses to stimuli, Cellular responses to stress, Lipid and atherosclerosis - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Protein processing in endoplasmic reticulum - Mus musculus (mouse), Unfolded Protein Response (UPR)
UniProt: F6VAN0
Entrez ID: 226641
|
Does Knockout of Ccdc85a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Ccdc85a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Ccdc85a (coiled-coil domain containing 85A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: adherens junction, anchoring junction
Pathways:
UniProt: Q5SP85
Entrez ID: 216613
|
Does Knockout of Spata20 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Spata20
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Spata20 (spermatogenesis associated 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cell differentiation, spermatogenesis
Pathways:
UniProt: Q80YT5
Entrez ID: 217116
|
Does Knockout of Mrpl37 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,838
|
Knockout
|
Mrpl37
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mrpl37 (mitochondrial ribosomal protein L37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrial ribosome, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Translation
UniProt: Q921S7
Entrez ID: 56280
|
Does Knockout of Tra2a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Tra2a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tra2a (transformer 2 alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA splicing, mRNA processing, mRNA splicing, via spliceosome, positive regulation of mRNA splicing, via spliceosome; MF: RNA binding, identical protein binding, nucleic acid binding, protein binding; CC: nucleolus, nucleoplasm, nucleus, spliceosomal complex
Pathways: Alcoholic liver disease - Mus musculus (mouse), Spliceosome - Mus musculus (mouse)
UniProt: A0A0N4SVC2, E9QP00, A0A0N4SV13
Entrez ID: 101214
|
Does Knockout of Cebpz in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 2,477
|
Knockout
|
Cebpz
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Cebpz (CCAAT/enhancer binding protein zeta)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: CCAAT-binding factor complex, nucleoplasm, nucleus
Pathways:
UniProt: P53569
Entrez ID: 12607
|
Does Knockout of Nat9 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Nat9
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Nat9 (N-acetyltransferase 9 (GCN5-related, putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: N-acetyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, transferase activity, tubulin N-terminal-methionine acetyltransferase activity; CC: protein-containing complex
Pathways:
UniProt: Q3UG98
Entrez ID: 66176
|
Does Knockout of Ublcp1 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Ublcp1
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Ublcp1 (ubiquitin-like domain containing CTD phosphatase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of proteasome assembly; MF: hydrolase activity, metal ion binding, phosphoprotein phosphatase activity, proteasome regulatory particle binding, protein serine/threonine phosphatase activity; CC: nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: Q8BGR9
Entrez ID: 79560
|
Does Knockout of Calm5 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Calm5
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Calm5 (calmodulin 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: calcium ion binding, enzyme regulator activity, metal ion binding
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Alcoholism - Mus musculus (mouse), Aldosterone synthesis and secretion - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amphetamine addiction - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), Calcium signaling pathway - Mus musculus (mouse), Cellular senescence - Mus musculus (mouse), Circadian entrainment - Mus musculus (mouse), Dopaminergic synapse - Mus musculus (mouse), Estrogen signaling pathway - Mus musculus (mouse), Fluid shear stress and atherosclerosis - Mus musculus (mouse), Gastric acid secretion - Mus musculus (mouse), Glioma - Mus musculus (mouse), Glucagon signaling pathway - Mus musculus (mouse), GnRH signaling pathway - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Long-term potentiation - Mus musculus (mouse), Melanogenesis - Mus musculus (mouse), Neurotrophin signaling pathway - Mus musculus (mouse), Olfactory transduction - Mus musculus (mouse), Oocyte meiosis - Mus musculus (mouse), Oxytocin signaling pathway - Mus musculus (mouse), Parkinson disease - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Pertussis - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phototransduction - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Renin secretion - Mus musculus (mouse), Salivary secretion - Mus musculus (mouse), Tuberculosis - Mus musculus (mouse), Vascular smooth muscle contraction - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), cGMP-PKG signaling pathway - Mus musculus (mouse)
UniProt: A0A087WNL0, Q6W3E0
Entrez ID: 494124
|
Does Knockout of Fam168a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Fam168a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fam168a (family with sequence similarity 168, member A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of base-excision repair
Pathways:
UniProt: Q8BGZ2
Entrez ID: 319604
|
Does Knockout of Naa35 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,270
|
Knockout
|
Naa35
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Naa35 (N(alpha)-acetyltransferase 35, NatC auxiliary subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of apoptotic process, smooth muscle cell proliferation; CC: NatC complex, cytoplasm, cytosol, nucleoplasm, plasma membrane
Pathways:
UniProt: Q6PHQ8
Entrez ID: 78689
|
Does Knockout of Tbc1d24 in Melanoma Cell Line causally result in cell proliferation?
| 1
| 1,838
|
Knockout
|
Tbc1d24
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tbc1d24 (TBC1 domain family, member 24)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, cellular response to oxidative stress, dendrite development, negative regulation of cellular response to oxidative stress, neuron projection development, positive regulation of dendrite morphogenesis, positive regulation of excitatory postsynaptic potential, positive regulation of neuron migration, synaptic vesicle endocytosis; CC: cell junction, cell projection, cytoplasm, cytoplasmic vesicle, cytoplasmic vesicle membrane, membrane, neuromuscular junction, plasma membrane, presynapse, synapse, terminal bouton
Pathways: Membrane Trafficking, Rab regulation of trafficking, TBC/RABGAPs, Vesicle-mediated transport
UniProt: Q3UUG6
Entrez ID: 224617
|
Does Knockout of Myl2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,683
|
Knockout
|
Myl2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Myl2 (myosin, light polypeptide 2, regulatory, cardiac, slow)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cardiac muscle contraction, cardiac myofibril assembly, heart contraction, heart development, heart morphogenesis, muscle cell development, muscle cell fate specification, negative regulation of cell growth, positive regulation of the force of heart contraction, post-embryonic development, regulation of the force of heart contraction, ventricular cardiac muscle tissue morphogenesis; MF: actin monomer binding, calcium ion binding, metal ion binding, structural constituent of muscle; CC: A band, actin cytoskeleton, cardiac myofibril, contractile muscle fiber, cytoplasm, cytoskeleton, myofibril, myosin complex
Pathways: Adrenergic signaling in cardiomyocytes - Mus musculus (mouse), Apelin signaling pathway - Mus musculus (mouse), Cardiac muscle contraction - Mus musculus (mouse), Dilated cardiomyopathy - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Hypertrophic cardiomyopathy - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Muscle contraction, Regulation of actin cytoskeleton - Mus musculus (mouse), Salmonella infection - Mus musculus (mouse), Striated Muscle Contraction, Tight junction - Mus musculus (mouse)
UniProt: P51667
Entrez ID: 17906
|
Does Knockout of Tmem132a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Tmem132a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tmem132a (transmembrane protein 132A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of programmed cell death, negative regulation of protein catabolic process, positive regulation of Wnt protein secretion, positive regulation of Wnt signaling pathway; MF: protein binding, protein homodimerization activity; CC: Golgi apparatus, Golgi membrane, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q922P8
Entrez ID: 98170
|
Does Knockout of Cpne7 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 2,173
|
Knockout
|
Cpne7
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Cpne7 (copine VII)
Type: protein-coding
Summary: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008].
Gene Ontology: BP: cellular response to calcium ion; MF: calcium-dependent phospholipid binding, metal ion binding; CC: cytoplasm, membrane, nucleus, plasma membrane, synapse
Pathways: Glycerophospholipid biosynthesis, Metabolism, Metabolism of lipids, Phospholipid metabolism
UniProt: Q0VE82
Entrez ID: 102278
|
Does Knockout of Tm9sf2 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Tm9sf2
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Tm9sf2 (transmembrane 9 superfamily member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ceramide metabolic process, glycosphingolipid biosynthetic process, protein localization to membrane, regulation of heparan sulfate proteoglycan biosynthetic process; CC: Golgi apparatus, cytoplasm, cytoskeleton, endosome, endosome membrane, membrane, microtubule organizing center
Pathways:
UniProt: P58021
Entrez ID: 68059
|
Does Knockout of Mdfi in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,283
|
Knockout
|
Mdfi
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Mdfi (MyoD family inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell differentiation, dorsal/ventral axis specification, embryonic skeletal system morphogenesis, maintenance of protein location in cell, negative regulation of DNA-templated transcription, negative regulation of Wnt signaling pathway, negative regulation of transcription by RNA polymerase II, regulation of JNK cascade, regulation of Wnt signaling pathway, regulation of gene expression, trophoblast giant cell differentiation; MF: DNA-binding transcription factor binding, identical protein binding, protein binding, protein sequestering activity; CC: cytoplasm, nucleus
Pathways:
UniProt: P70331
Entrez ID: 17240
|
Does Knockout of Cggbp1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Cggbp1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cggbp1 (CGG triplet repeat binding protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: epigenetic regulation of gene expression, negative regulation of transcription by RNA polymerase II, regulation of gene expression, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor binding, double-stranded DNA binding, identical protein binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q8BHG9
Entrez ID: 106143
|
Does Knockout of Atp8b4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Atp8b4
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Atp8b4 (ATPase, class I, type 8B, member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi organization, lipid transport, phospholipid translocation, phospholipid transport; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, magnesium ion binding, metal ion binding, nucleotide binding; CC: Golgi apparatus, cytoplasm, endomembrane system, membrane, phospholipid-translocating ATPase complex, plasma membrane, trans-Golgi network
Pathways: Immune System, Innate Immune System, Ion channel transport, Ion transport by P-type ATPases, Neutrophil degranulation, Transport of small molecules
UniProt: A2ANX3, A1L3S5, Q69Z59, F2Z411, A2ANX2
Entrez ID: 241633
|
Does Knockout of Mmel1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,680
|
Knockout
|
Mmel1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mmel1 (membrane metallo-endopeptidase-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein processing, proteolysis; MF: endopeptidase activity, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding; CC: Golgi apparatus, endoplasmic reticulum, extracellular region, extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q9JLI3
Entrez ID: 27390
|
Does Knockout of Tmem98 in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Tmem98
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Tmem98 (transmembrane protein 98)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: T-helper 1 cell differentiation, canonical Wnt signaling pathway, gene expression, negative regulation of myelination, negative regulation of oligodendrocyte differentiation, negative regulation of protein localization to nucleus, negative regulation of protein processing; CC: Golgi apparatus, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, extracellular region, extracellular space, membrane, plasma membrane
Pathways:
UniProt: Q91X86
Entrez ID: 103743
|
Does Knockout of Cct4 in Colonic Cancer Cell Line causally result in cell proliferation?
| 1
| 1,264
|
Knockout
|
Cct4
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Cct4 (chaperonin containing TCP1 subunit 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: binding of sperm to zona pellucida, positive regulation of telomerase RNA localization to Cajal body, positive regulation of telomere maintenance via telomerase, protein folding, protein stabilization, scaRNA localization to Cajal body; MF: ATP binding, ATP hydrolysis activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, protein binding, protein folding chaperone, unfolded protein binding; CC: cell body, cell projection, centrosome, chaperonin-containing T-complex, cilium, cytoplasm, cytoskeleton, cytosol, melanosome, microtubule, nucleoplasm, zona pellucida receptor complex
Pathways: Association of TriC/CCT with target proteins during biosynthesis, Chaperonin-mediated protein folding, Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding, Metabolism of proteins, Protein folding
UniProt: P80315
Entrez ID: 12464
|
Does Knockout of Fmo2 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Fmo2
|
phagocytosis
|
macrophage
|
Gene: Fmo2 (flavin containing monooxygenase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NADP+ metabolic process, energy homeostasis, negative regulation of fatty acid oxidation, organic acid metabolic process, oxygen metabolic process, toxin metabolic process, xenobiotic metabolic process; MF: N,N-dimethylaniline monooxygenase activity, NADP binding, flavin adenine dinucleotide binding, monooxygenase activity, oxidoreductase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: Biological oxidations, Drug metabolism - cytochrome P450 - Mus musculus (mouse), FMO oxidises nucleophiles, Metabolism, Phase I - Functionalization of compounds, nicotine degradation II
UniProt: Q8K2I3
Entrez ID: 55990
|
Does Knockout of Mbnl1 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,308
|
Knockout
|
Mbnl1
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Mbnl1 (muscleblind like splicing regulator 1)
Type: protein-coding
Summary: Predicted to enable double-stranded RNA binding activity and regulatory region RNA binding activity. Involved in several processes, including embryonic limb morphogenesis; in utero embryonic development; and myoblast differentiation. Acts upstream of or within alternative mRNA splicing, via spliceosome; mRNA splice site recognition; and skeletal muscle tissue development. Located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb bud; and retina. Used to study myotonic disease and myotonic dystrophy type 1. Orthologous to human MBNL1 (muscleblind like splicing regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: RNA splicing, alternative mRNA splicing, via spliceosome, embryonic limb morphogenesis, in utero embryonic development, mRNA processing, mRNA splice site recognition, myoblast differentiation, nervous system development, regulation of RNA splicing, regulation of alternative mRNA splicing, via spliceosome, skeletal muscle tissue development; MF: RNA binding, double-stranded RNA binding, metal ion binding, regulatory region RNA binding, zinc ion binding; CC: cytoplasm, cytoplasmic stress granule, cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q9JKP5
Entrez ID: 56758
|
Does Knockout of 1700010B08Rik in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
1700010B08Rik
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: 1700010B08Rik (RIKEN cDNA 1700010B08 gene)
Type: ncRNA
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID: 75485
|
Does Knockout of Scd2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Scd2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Scd2 (stearoyl-Coenzyme A desaturase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fatty acid biosynthetic process, fatty acid metabolic process, lipid metabolic process, monounsaturated fatty acid biosynthetic process, response to fatty acid, unsaturated fatty acid biosynthetic process; MF: acyl-CoA desaturase activity, iron ion binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water, palmitoyl-CoA 9-desaturase activity, stearoyl-CoA 9-desaturase activity; CC: endoplasmic reticulum, endoplasmic reticulum membrane, membrane, nucleolus
Pathways: AMPK signaling pathway - Mus musculus (mouse), Alcoholic liver disease - Mus musculus (mouse), Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid metabolism, Fatty acyl-CoA biosynthesis, Metabolism, Metabolism of lipids, PPAR signaling pathway - Mus musculus (mouse), oleate biosynthesis II (animals)
UniProt: P13011
Entrez ID: 20250
|
Does Knockout of Cryba2 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Cryba2
|
phagocytosis
|
macrophage
|
Gene: Cryba2 (crystallin, beta A2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: eye development, lens development in camera-type eye, visual perception; MF: identical protein binding, structural constituent of eye lens
Pathways:
UniProt: Q9JJV1
Entrez ID: 12958
|
Does Knockout of Tpk1 in Microglial Cell Line causally result in response to virus?
| 0
| 1,438
|
Knockout
|
Tpk1
|
response to virus
|
Microglial Cell Line
|
Gene: Tpk1 (thiamine pyrophosphokinase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of pyruvate decarboxylation to acetyl-CoA, thiamine diphosphate biosynthetic process, thiamine metabolic process; MF: ATP binding, UTP thiamine diphosphokinase activity, identical protein binding, kinase activity, nucleotide binding, thiamine binding, thiamine diphosphokinase activity, transferase activity; CC: cytosol
Pathways: Metabolism, Metabolism of vitamins and cofactors, Metabolism of water-soluble vitamins and cofactors, Thiamine metabolism - Mus musculus (mouse), Vitamin B1 (thiamin) metabolism
UniProt: Q9R0M5
Entrez ID: 29807
|
Does Knockout of Cdr1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Cdr1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Cdr1 (cerebellar degeneration related antigen 1)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Vmn2r120 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Vmn2r120
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Vmn2r120 (vomeronasal 2, receptor 120)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A3Q4L2R4, A0A8V5KX69, A0A3Q4EHP3, A0A3Q4EGT3, A0A3Q4EI01, A0A3Q4EGU0, A0A3Q4EC41, A0A3Q4EGZ3, A0A3Q4EGL8, A0A3Q4EHE9, A0A3Q4EG47, E9PX34, A0A3Q4L2S4, A0A3Q4EG75, A0A3Q4EGA5, A0A3Q4EG79, A0A3Q4L2Y3
Entrez ID: 224916
|
Does Knockout of Focad in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Focad
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Focad (focadhesin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, regulation of post-transcriptional gene silencing; CC: anchoring junction, cytoplasm, cytosol, focal adhesion
Pathways:
UniProt: A2AKG8
Entrez ID: 230393
|
Does Knockout of Rtn1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Rtn1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Rtn1 (reticulon 1)
Type: protein-coding
Summary: Predicted to be involved in endoplasmic reticulum tubular network formation; negative regulation of amyloid-beta formation; and nervous system development. Located in dendrite; endoplasmic reticulum; and neuronal cell body. Is expressed in several structures, including genitourinary system; immune system; nervous system; neural retina; and skin. Orthologous to human RTN1 (reticulon 1). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: brain development, endoplasmic reticulum tubular network formation, endoplasmic reticulum tubular network membrane organization, negative regulation of amyloid-beta formation, neuron differentiation; CC: Golgi apparatus, Golgi membrane, dendrite, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, neuron projection, neuronal cell body, nuclear body, postsynaptic density, smooth endoplasmic reticulum
Pathways:
UniProt: Q8K0T0
Entrez ID: 104001
|
Does Activation of Gpaa1 in Liver cell line causally result in tumorigenicity?
| 0
| 2,372
|
Activation
|
Gpaa1
|
tumorigenicity
|
Liver cell line
|
Gene: Gpaa1 (GPI anchor attachment protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: GPI anchor biosynthetic process, GPI anchored protein biosynthesis, attachment of GPI anchor to protein; MF: GPI anchor binding, GPI-anchor transamidase activity, metal ion binding; CC: GPI-anchor transamidase complex, centrosome, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrion, plasma membrane
Pathways: Attachment of GPI anchor to uPAR, Glycosylphosphatidylinositol (GPI)-anchor biosynthesis - Mus musculus (mouse), Metabolism of proteins, Post-translational modification: synthesis of GPI-anchored proteins, Post-translational protein modification
UniProt: Q9WTK3
Entrez ID: 14731
|
Does Knockout of Trim52 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Trim52
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Trim52 (tripartite motif-containing 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: defense response to virus, innate immune response, positive regulation of canonical NF-kappaB signal transduction, protein autoubiquitination, protein ubiquitination; MF: metal ion binding, transcription coactivator activity, ubiquitin protein ligase activity, zinc ion binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q8CDV4
Entrez ID: 212085
|
Does Knockout of Gm4871 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Gm4871
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Gm4871 (predicted gene 4871)
Type: protein-coding
Summary: predicted gene 4871
Gene Ontology: MF: guanyl-nucleotide exchange factor activity, molecular_function
Pathways:
UniProt: D3Z0W7
Entrez ID: 231885
|
Does Knockout of Wdr75 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Wdr75
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Wdr75 (WD repeat domain 75)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of rRNA processing, positive regulation of transcription by RNA polymerase I, rRNA processing, ribosomal small subunit biogenesis, ribosome biogenesis; MF: RNA binding; CC: nucleolus, nucleus, small-subunit processome
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q3U821
Entrez ID: 73674
|
Does Knockout of Ubtf in Acute Myeloid Leukemia Cell Line causally result in cell proliferation?
| 1
| 685
|
Knockout
|
Ubtf
|
cell proliferation
|
Acute Myeloid Leukemia Cell Line
|
Gene: Ubtf (upstream binding transcription factor, RNA polymerase I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase I preinitiation complex assembly, cellular response to leukemia inhibitory factor, positive regulation of transcription by RNA polymerase I, rDNA heterochromatin formation, transcription by RNA polymerase I, transcription elongation by RNA polymerase I, transcription initiation at RNA polymerase I promoter; MF: DNA binding, RNA polymerase I cis-regulatory region sequence-specific DNA binding, RNA polymerase I core promoter sequence-specific DNA binding, RNA polymerase I general transcription initiation factor activity, chromatin binding, protein binding, scaffold protein binding; CC: fibrillar center, nucleolus, nucleus
Pathways:
UniProt: A2AWT5, A2AWT6, E9Q4A8, A2AWT7, Q9DBH1, G3UZW9
Entrez ID: 21429
|
Does Knockout of Cntrl in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 82
|
Knockout
|
Cntrl
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cntrl (centriolin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aorta development, cardiac septum development, cell division, coronary vasculature development, female germ-line stem cell asymmetric division, kidney development, ventricular septum development; CC: Flemming body, Golgi apparatus, centriolar satellite, centriolar subdistal appendage, centrosome, ciliary basal body, cytoplasm, cytoskeleton, cytosol, meiotic spindle, meiotic spindle pole, microtubule cytoskeleton, mitotic spindle pole, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: A2AL36
Entrez ID: 26920
|
Does Knockout of Lrrc52 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Lrrc52
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Lrrc52 (leucine rich repeat containing 52)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: establishment of localization in cell, monoatomic ion transmembrane transport, monoatomic ion transport, potassium ion transmembrane transport, potassium ion transport; MF: potassium channel activator activity, potassium channel activity, transmembrane transporter binding, voltage-gated potassium channel activity; CC: membrane, plasma membrane, voltage-gated potassium channel complex
Pathways:
UniProt: Q5M8M9
Entrez ID: 240899
|
Does Knockout of Lrrc15 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Lrrc15
|
phagocytosis
|
macrophage
|
Gene: Lrrc15 (leucine rich repeat containing 15)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: entry receptor-mediated virion attachment to host cell, host-mediated suppression of symbiont invasion, negative regulation of protein localization to plasma membrane, positive regulation of cell migration, positive regulation of synapse assembly, receptor-mediated virion attachment to host cell; MF: collagen binding, fibronectin binding, laminin binding, protein sequestering activity, signaling receptor activity; CC: apical plasma membrane, cell surface, membrane, plasma membrane
Pathways:
UniProt: Q80X72
Entrez ID: 74488
|
Does Knockout of Copa in Microglial Cell Line causally result in response to virus?
| 1
| 1,438
|
Knockout
|
Copa
|
response to virus
|
Microglial Cell Line
|
Gene: Copa (coatomer protein complex subunit alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, intra-Golgi vesicle-mediated transport, intracellular protein transport, pancreatic juice secretion, protein localization to axon, protein localization to cell leading edge, protein transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, signal transduction, vesicle-mediated transport; MF: hormone activity, mRNA binding, protein binding, structural molecule activity; CC: COPI vesicle coat, COPI-coated vesicle, COPI-coated vesicle membrane, Golgi apparatus, Golgi membrane, axon, cytoplasm, cytoplasmic vesicle, extracellular region, extracellular space, growth cone, membrane, membrane coat, neuronal cell body
Pathways: Asparagine N-linked glycosylation, COPI-dependent Golgi-to-ER retrograde traffic, COPI-mediated anterograde transport, ER to Golgi Anterograde Transport, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q8CIE6
Entrez ID: 12847
|
Does Knockout of Wdr41 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Wdr41
|
cell proliferation
|
Regulatory T cell
|
Gene: Wdr41 (WD repeat domain 41)
Type: protein-coding
Summary: This gene encodes a protein of unknown function, but which contains a WD40 domain consisting of six WD40 repeats. The WD40 domain is one of the most abundant protein domains in eukaryotes, and is found in proteins with widely varying cellular functions. However, proteins with this domain often provide a rigid scaffold for protein-protein interactions. [provided by RefSeq, Aug 2012].
Gene Ontology: BP: autophagy, negative regulation of exocytosis, negative regulation of immune response, regulation of autophagy; MF: GTPase activator activity, guanyl-nucleotide exchange factor activity; CC: cytoplasm, guanyl-nucleotide exchange factor complex
Pathways: Amyotrophic lateral sclerosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse)
UniProt: Q3UDP0
Entrez ID: 218460
|
Does Knockout of Rspo4 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Rspo4
|
cell proliferation
|
Regulatory T cell
|
Gene: Rspo4 (R-spondin 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, limb development, nail development, positive regulation of Wnt signaling pathway, positive regulation of canonical Wnt signaling pathway; MF: heparin binding, signaling receptor binding; CC: extracellular region, extracellular space
Pathways: Regulation of FZD by ubiquitination, Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q8BJ73
Entrez ID: 228770
|
Does Knockout of Gm5849 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Gm5849
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gm5849 (predicted gene 5849)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: antimicrobial humoral immune response mediated by antimicrobial peptide, astrocyte development, autocrine signaling, autophagy, chronic inflammatory response, endothelial cell migration, leukocyte migration involved in inflammatory response, neutrophil aggregation, neutrophil chemotaxis, positive regulation of inflammatory response, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of neuron projection development; MF: calcium ion binding, calcium-dependent protein binding, metal ion binding; CC: S100A9 complex, calprotectin complex, cytoplasm, extracellular region, extracellular space, plasma membrane
Pathways:
UniProt:
Entrez ID: 545541
|
Does Knockout of Ocln in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Ocln
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ocln (occludin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bicellular tight junction assembly, cell-cell junction organization, negative regulation of gene expression, positive regulation of D-glucose import, positive regulation of blood-brain barrier permeability, positive regulation of gene expression, regulation of D-glucose transmembrane transport, response to interleukin-18, tight junction organization; MF: protein binding, protein domain specific binding; CC: anchoring junction, apical plasma membrane, apicolateral plasma membrane, bicellular tight junction, cell junction, cell surface, cell-cell junction, cytoplasmic vesicle, endocytic vesicle, lateral plasma membrane, lysosomal membrane, membrane, plasma membrane, protein-containing complex, tight junction
Pathways: Cell adhesion molecules - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: Q61146
Entrez ID: 18260
|
Does Knockout of Pars2 in Colonic Cancer Cell Line causally result in tumorigenicity?
| 0
| 2,177
|
Knockout
|
Pars2
|
tumorigenicity
|
Colonic Cancer Cell Line
|
Gene: Pars2 (prolyl-tRNA synthetase (mitochondrial)(putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: prolyl-tRNA aminoacylation, tRNA aminoacylation for protein translation, translation; MF: ATP binding, aminoacyl-tRNA ligase activity, ligase activity, nucleotide binding, proline-tRNA ligase activity; CC: cytoplasm, mitochondrial matrix, mitochondrion
Pathways: Aminoacyl-tRNA biosynthesis - Mus musculus (mouse), tRNA charging pathway
UniProt: Q8CFI5
Entrez ID: 230577
|
Does Knockout of Ahsg in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Ahsg
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Ahsg (alpha-2-HS-glycoprotein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: acute-phase response, male gonad development, negative regulation of bone mineralization, negative regulation of cell growth, negative regulation of insulin receptor signaling pathway, ossification, positive regulation of bone resorption, positive regulation of phagocytosis, protein-containing complex assembly, regulation of inflammatory response; MF: cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, receptor signaling protein tyrosine kinase inhibitor activity; CC: Golgi apparatus, extracellular matrix, extracellular region, extracellular space, protein-containing complex
Pathways: Hemostasis, Immune System, Innate Immune System, Metabolism of proteins, Neutrophil degranulation, Platelet activation, signaling and aggregation, Platelet degranulation , Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), Response to elevated platelet cytosolic Ca2+
UniProt: P29699
Entrez ID: 11625
|
Does Knockout of Nqo2 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Nqo2
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Nqo2 (N-ribosyldihydronicotinamide quinone reductase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of ERK1 and ERK2 cascade, positive regulation of neuron apoptotic process, positive regulation of reactive oxygen species metabolic process, positive regulation of vascular associated smooth muscle cell proliferation, quinone catabolic process; MF: FAD binding, NAD(P)H dehydrogenase (quinone) activity, chloride ion binding, dihydronicotinamide riboside quinone reductase activity, electron transfer activity, melatonin binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on other nitrogenous compounds as donors, protein homodimerization activity, resveratrol binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm
Pathways: Biological oxidations, Metabolism, Phase I - Functionalization of compounds
UniProt: Q9JI75
Entrez ID: 18105
|
Does Knockout of Tm9sf4 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Tm9sf4
|
response to bacteria
|
renal medulla cell line
|
Gene: Tm9sf4 (transmembrane 9 superfamily member 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, phagocytosis, positive regulation of protein exit from endoplasmic reticulum, positive regulation of protein localization to cell surface, protein localization to membrane, regulation of intracellular pH, response to hypoxia, vacuolar proton-transporting V-type ATPase complex assembly; CC: Golgi apparatus, early endosome, endosome, membrane
Pathways:
UniProt: Q8BH24
Entrez ID: 99237
|
Does Knockout of Snrpd3 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Snrpd3
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Snrpd3 (small nuclear ribonucleoprotein D3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA processing, RNA splicing, mRNA processing, mRNA splicing, via spliceosome, spliceosomal snRNP assembly; MF: RNA binding, U1 snRNP binding, U7 snRNA binding, enzyme binding, histone pre-mRNA DCP binding, telomerase RNA binding; CC: SMN-Sm protein complex, U1 snRNP, U12-type spliceosomal complex, U2 snRNP, U2-type catalytic step 2 spliceosome, U2-type precatalytic spliceosome, U2-type spliceosomal complex, U4 snRNP, U4/U6 x U5 tri-snRNP complex, U5 snRNP, U7 snRNP, catalytic step 2 spliceosome, commitment complex, cytoplasm, cytosol, methylosome, nuclear body, nucleoplasm, nucleus, pICln-Sm protein complex, precatalytic spliceosome, ribonucleoprotein complex, spliceosomal complex, spliceosomal tri-snRNP complex, telomerase holoenzyme complex
Pathways: Gene expression (Transcription), Metabolism of RNA, Metabolism of non-coding RNA, Processing of Capped Intron-Containing Pre-mRNA, Processing of Capped Intronless Pre-mRNA, RNA Polymerase II Transcription, RNA Polymerase II Transcription Termination, SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs, SLBP independent Processing of Histone Pre-mRNAs, Spliceosome - Mus musculus (mouse), Systemic lupus erythematosus - Mus musculus (mouse), mRNA Splicing, mRNA Splicing - Major Pathway, mRNA Splicing - Minor Pathway, snRNP Assembly
UniProt: P62320
Entrez ID: 67332
|
Does Knockout of Mrpl9 in Cytotoxic T-lymphocyte (CD8+ T cells) causally result in cell proliferation?
| 1
| 2,411
|
Knockout
|
Mrpl9
|
cell proliferation
|
Cytotoxic T-lymphocyte (CD8+ T cells)
|
Gene: Mrpl9 (mitochondrial ribosomal protein L9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial translation, translation; CC: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q99N94
Entrez ID: 78523
|
Does Knockout of Dbr1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Dbr1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Dbr1 (debranching RNA lariats 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA fragment catabolic process, RNA splicing, via transesterification reactions, mRNA processing, mRNA splicing, via spliceosome; MF: RNA lariat debranching enzyme activity, hydrolase activity, hydrolase activity, acting on ester bonds, metal ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q923B1
Entrez ID: 83703
|
Does Knockout of Inca1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Inca1
|
cell proliferation
|
Regulatory T cell
|
Gene: Inca1 (inhibitor of CDK, cyclin A1 interacting protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: apoptotic signaling pathway, negative regulation of cell population proliferation, negative regulation of fibroblast proliferation, positive regulation of apoptotic signaling pathway; MF: cyclin binding, cyclin-dependent protein serine/threonine kinase inhibitor activity, identical protein binding, protein binding, protein kinase inhibitor activity, protein-containing complex binding; CC: cytoplasm, nuclear body, nucleoplasm, nucleus
Pathways:
UniProt: Q6PKN7
Entrez ID: 103844
|
Does Knockout of Krt40 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Krt40
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Krt40 (keratin 40)
Type: protein-coding
Summary: Predicted to enable structural molecule activity. Predicted to be involved in epithelial cell differentiation and intermediate filament organization. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Orthologous to human KRT40 (keratin 40). [provided by Alliance of Genome Resources, Apr 2025]
Gene Ontology: BP: epithelial cell differentiation, intermediate filament organization, morphogenesis of an epithelium; MF: structural constituent of skin epidermis, structural molecule activity; CC: cytoskeleton, intermediate filament, keratin filament
Pathways: Developmental Biology, Estrogen signaling pathway - Mus musculus (mouse), Formation of the cornified envelope, Keratinization, Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: Q6IFX3
Entrez ID: 406221
|
Does Knockout of Vwa7 in Microglial Cell Line causally result in protein/peptide distribution?
| 0
| 1,585
|
Knockout
|
Vwa7
|
protein/peptide distribution
|
Microglial Cell Line
|
Gene: Vwa7 (von Willebrand factor A domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q9JHA8
Entrez ID: 27762
|
Does Knockout of Atp8a2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Atp8a2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Atp8a2 (ATPase, aminophospholipid transporter-like, class I, type 8A, member 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: aminophospholipid translocation, axonogenesis, detection of light stimulus involved in visual perception, determination of adult lifespan, eating behavior, inner ear morphogenesis, involuntary skeletal muscle contraction, lipid transport, neurofilament cytoskeleton organization, neuromuscular process controlling posture, neuron development, neuron projection development, phospholipid translocation, phospholipid transport, positive regulation of multicellular organism growth, positive regulation of neuron projection development, positive regulation of phospholipid translocation, response to auditory stimulus, retina layer formation, skin development; MF: ATP binding, ATP hydrolysis activity, ATPase-coupled intramembrane lipid transporter activity, aminophospholipid flippase activity, magnesium ion binding, metal ion binding, nucleotide binding, phosphatidylethanolamine flippase activity, phosphatidylserine flippase activity, phosphatidylserine floppase activity; CC: Golgi apparatus, Golgi membrane, cell projection, endosome, endosome membrane, membrane, nucleoplasm, phospholipid-translocating ATPase complex, plasma membrane, trans-Golgi network
Pathways: Ion channel transport, Ion transport by P-type ATPases, Transport of small molecules
UniProt: P98200
Entrez ID: 50769
|
Does Knockout of Ercc1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Ercc1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ercc1 (excision repair cross-complementing rodent repair deficiency, complementation group 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA recombination, DNA repair, UV protection, UV-damage excision repair, cell development, cell population proliferation, chromosome organization, determination of adult lifespan, double-strand break repair, double-strand break repair via nonhomologous end joining, germ cell development, insulin-like growth factor receptor signaling pathway, interstrand cross-link repair, isotype switching, male gonad development, mitotic recombination, multicellular organism growth, negative regulation of protection from non-homologous end joining at telomere, negative regulation of telomere maintenance, nucleotide-excision repair, oogenesis, positive regulation of t-circle formation, positive regulation of transcription initiation by RNA polymerase II, post-embryonic hemopoiesis, pyrimidine dimer repair by nucleotide-excision repair, regulation of telomere maintenance, replicative senescence, response to X-ray, response to oxidative stress, spermatogenesis, syncytium formation, t-circle formation, telomere maintenance, telomeric DNA-containing double minutes formation; MF: 3' overhang single-stranded DNA endodeoxyribonuclease activity, DNA binding, TFIID-class transcription factor complex binding, damaged DNA binding, promoter-specific chromatin binding, protein binding, single-stranded DNA binding, single-stranded DNA endodeoxyribonuclease activity; CC: ERCC4-ERCC1 complex, chromosome, telomeric region, nucleoplasm, nucleotide-excision repair complex, nucleotide-excision repair factor 1 complex, nucleus
Pathways: DNA Double-Strand Break Repair, DNA Repair, Dual Incision in GG-NER, Dual incision in TC-NER, Fanconi Anemia Pathway, Fanconi anemia pathway - Mus musculus (mouse), Formation of Incision Complex in GG-NER, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), Transcription-Coupled Nucleotide Excision Repair (TC-NER)
UniProt: P07903
Entrez ID: 13870
|
Does Knockout of Pik3c2g in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Pik3c2g
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Pik3c2g (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell migration, chemotaxis, host-mediated perturbation of viral process, lipid metabolic process, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, kinase activity, nucleotide binding, phosphatidylinositol binding, transferase activity; CC: cytoplasm, membrane, nuclear envelope, plasma membrane
Pathways: 3-phosphoinositide biosynthesis, Inositol phosphate metabolism - Mus musculus (mouse), Metabolism, Metabolism of lipids, PI Metabolism, PIP metabolism, Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipid metabolism, Salmonella infection - Mus musculus (mouse), Synthesis of PIPs at the Golgi membrane, Synthesis of PIPs at the plasma membrane
UniProt: O70167
Entrez ID: 18705
|
Does Knockout of Rpn1 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 1
| 1,261
|
Knockout
|
Rpn1
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Rpn1 (ribophorin I)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein N-linked glycosylation, protein N-linked glycosylation via asparagine, protein glycosylation; CC: cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, oligosaccharyltransferase complex, oligosaccharyltransferase complex A, oligosaccharyltransferase complex B, rough endoplasmic reticulum
Pathways: Adaptive Immune System, Adherens junctions interactions, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Co-inhibition by PD-1, Immune System, N-Glycan biosynthesis - Mus musculus (mouse), PD-L1(CD274) glycosylation and translocation to plasma membrane, Protein processing in endoplasmic reticulum - Mus musculus (mouse), Regulation of CDH1 Expression and Function, Regulation of CDH1 posttranslational processing and trafficking to plasma membrane, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) Post-translational modification, Regulation of PD-L1(CD274) expression, Regulation of T cell activation by CD28 family, Various types of N-glycan biosynthesis - Mus musculus (mouse)
UniProt: Q91YQ5
Entrez ID: 103963
|
Does Knockout of Atxn7l3b in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 84
|
Knockout
|
Atxn7l3b
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Atxn7l3b (ataxin 7-like 3B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: regulation of gene expression; CC: cytoplasm
Pathways:
UniProt: Q3UD01
Entrez ID: 382423
|
Does Knockout of Med18 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,271
|
Knockout
|
Med18
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Med18 (mediator complex subunit 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II preinitiation complex assembly, positive regulation of transcription elongation by RNA polymerase II, positive regulation of transcription initiation by RNA polymerase II, protein ubiquitination, regulation of transcription by RNA polymerase II; MF: transcription coregulator activity, ubiquitin protein ligase activity; CC: core mediator complex, mediator complex, nucleoplasm, nucleus, ubiquitin ligase complex
Pathways:
UniProt: Q9CZ82
Entrez ID: 67219
|
Does Knockout of Scnm1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Scnm1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Scnm1 (sodium channel modifier 1)
Type:
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt:
Entrez ID:
|
Does Knockout of Ascc2 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Ascc2
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Ascc2 (activating signal cointegrator 1 complex subunit 2)
Type: protein-coding
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and ubiquitin binding activity. Predicted to be involved in regulation of DNA-templated transcription; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of DNA repair complex and RQC-trigger complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including adrenal gland; alimentary system; aorta; brain; and genitourinary system. Orthologous to human ASCC2 (activating signal cointegrator 1 complex subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: DNA damage response, DNA repair, regulation of DNA-templated transcription, rescue of stalled ribosome, ribosome disassembly, ribosome-associated ubiquitin-dependent protein catabolic process; MF: K63-linked polyubiquitin modification-dependent protein binding, ubiquitin binding; CC: DNA repair complex, RQC-trigger complex, cytosolic ribosome, nuclear speck, nucleus
Pathways: Metabolism of proteins, Ribosome-associated quality control, Translation, ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
UniProt: Q91WR3
Entrez ID: 75452
|
Does Knockout of Ifrd1 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Ifrd1
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Ifrd1 (interferon-related developmental regulator 1)
Type: protein-coding
Summary: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including adipose tissue development; fat cell differentiation; and negative regulation of axonogenesis. Located in nucleus and sarcoplasm. Is expressed in several structures, including extraembryonic component; liver and biliary system; nasal cavity epithelium; nervous system; and tooth. Orthologous to human IFRD1 (interferon related developmental regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Wnt signaling pathway, adipose tissue development, cell differentiation, fat cell differentiation, muscle cell differentiation, negative regulation of axon extension, negative regulation of collateral sprouting, positive regulation of transcription by RNA polymerase II, regulation of transcription by RNA polymerase II, skeletal muscle tissue regeneration, striated muscle tissue development; CC: cytoplasm, nucleus, sarcoplasm
Pathways:
UniProt: P19182
Entrez ID: 15982
|
Does Knockout of Pik3ca in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Pik3ca
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Pik3ca (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: TORC2 signaling, actin cytoskeleton organization, adipose tissue development, angiogenesis, autosome genomic imprinting, cardiac muscle cell contraction, cell migration, cellular response to glucose stimulus, cellular response to hydrostatic pressure, cellular response to insulin stimulus, energy homeostasis, glucose metabolic process, insulin receptor signaling pathway, insulin-like growth factor receptor signaling pathway, liver development, negative regulation of actin filament depolymerization, negative regulation of anoikis, negative regulation of fibroblast apoptotic process, negative regulation of gene expression, negative regulation of neuron apoptotic process, phagocytosis, phosphatidylinositol 3-kinase/protein kinase B signal transduction, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-mediated signaling, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction, positive regulation of protein localization to membrane, positive regulation of smooth muscle cell proliferation, regulation of actin filament organization, regulation of cellular respiration, regulation of gene expression, regulation of multicellular organism growth, relaxation of cardiac muscle, response to L-leucine, response to activity, response to butyrate, response to dexamethasone, response to hormone, response to muscle inactivity, response to muscle stretch, vascular endothelial growth factor signaling pathway; MF: 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding, insulin receptor substrate binding, kinase activity, nucleotide binding, protein binding, protein kinase activator activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, intercalated disc, lamellipodium, phosphatidylinositol 3-kinase complex, phosphatidylinositol 3-kinase complex, class IA, phosphatidylinositol 3-kinase complex, class IB, plasma membrane
Pathways: 3-phosphoinositide biosynthesis, AGE-RAGE signaling pathway in diabetic complications - Mus musculus (mouse), AMPK signaling pathway - Mus musculus (mouse), Acute myeloid leukemia - Mus musculus (mouse), Adaptive Immune System, Aldosterone-regulated sodium reabsorption - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amoebiasis - Mus musculus (mouse), Apoptosis - Mus musculus (mouse), Autophagy - animal - Mus musculus (mouse), Axon guidance, Axon guidance - Mus musculus (mouse), B cell receptor signaling pathway - Mus musculus (mouse), Bacterial invasion of epithelial cells - Mus musculus (mouse), Breast cancer - Mus musculus (mouse), C-type lectin receptor signaling pathway - Mus musculus (mouse), CD28 dependent PI3K/Akt signaling, Carbohydrate digestion and absorption - Mus musculus (mouse), Cell surface interactions at the vascular wall, Cellular senescence - Mus musculus (mouse), Central carbon metabolism in cancer - Mus musculus (mouse), Chagas disease - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Chemical carcinogenesis - receptor activation - Mus musculus (mouse), Chemokine signaling pathway - Mus musculus (mouse), Choline metabolism in cancer - Mus musculus (mouse), Cholinergic synapse - Mus musculus (mouse), Chronic myeloid leukemia - Mus musculus (mouse), Co-stimulation by CD28, Co-stimulation by ICOS, Colorectal cancer - Mus musculus (mouse), Coronavirus disease - COVID-19 - Mus musculus (mouse), Cytokine Signaling in Immune system, DAP12 interactions, DAP12 signaling, Developmental Biology, Diabetic cardiomyopathy - Mus musculus (mouse), Downstream TCR signaling, Downstream signal transduction, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, ESR-mediated signaling, Endometrial cancer - Mus musculus (mouse), Epstein-Barr virus infection - Mus musculus (mouse), ErbB signaling pathway - Mus musculus (mouse), Erythropoietin activates Phosphoinositide-3-kinase (PI3K), Estrogen signaling pathway - Mus musculus (mouse), Extra-nuclear estrogen signaling, FLT3 Signaling, Fc epsilon RI signaling pathway - Mus musculus (mouse), Fc epsilon receptor (FCERI) signaling, Fc gamma R-mediated phagocytosis - Mus musculus (mouse), Fcgamma receptor (FCGR) dependent phagocytosis, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), FoxO signaling pathway - Mus musculus (mouse), G alpha (q) signalling events, GAB1 signalosome, GPCR downstream signalling, GPVI-mediated activation cascade, Gastric cancer - Mus musculus (mouse), Glioma - Mus musculus (mouse), GnRH secretion - Mus musculus (mouse), Growth hormone synthesis, secretion and action - Mus musculus (mouse), HIF-1 signaling pathway - Mus musculus (mouse), Hemostasis, Hepatitis B - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human T-cell leukemia virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Human papillomavirus infection - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Immune System, Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Influenza A - Mus musculus (mouse), Innate Immune System, Inositol phosphate metabolism - Mus musculus (mouse), Insulin receptor signalling cascade, Insulin resistance - Mus musculus (mouse), Insulin signaling pathway - Mus musculus (mouse), Interleukin receptor SHC signaling, Interleukin-2 family signaling, Interleukin-3, Interleukin-5 and GM-CSF signaling, Intracellular signaling by second messengers, JAK-STAT signaling pathway - Mus musculus (mouse), Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), Longevity regulating pathway - Mus musculus (mouse), Longevity regulating pathway - multiple species - Mus musculus (mouse), MAPK family signaling cascades, MAPK1/MAPK3 signaling, MET activates PI3K/AKT signaling, Measles - Mus musculus (mouse), Melanoma - Mus musculus (mouse), Metabolism, Metabolism of lipids, MicroRNAs in cancer - Mus musculus (mouse), Natural killer cell mediated cytotoxicity - Mus musculus (mouse), Negative regulation of the PI3K/AKT network, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), Neutrophil extracellular trap formation - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Non-small cell lung cancer - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), PD-L1 expression and PD-1 checkpoint pathway in cancer - Mus musculus (mouse), PI Metabolism, PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K events in ERBB2 signaling, PI3K events in ERBB4 signaling, PI3K-Akt signaling pathway - Mus musculus (mouse), PI3K/AKT activation, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP metabolism, PIP3 activates AKT signaling, Pancreatic cancer - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Phosphatidylinositol signaling system - Mus musculus (mouse), Phospholipase D signaling pathway - Mus musculus (mouse), Phospholipid metabolism, Platelet activation - Mus musculus (mouse), Platelet activation, signaling and aggregation, Prion disease - Mus musculus (mouse), Progesterone-mediated oocyte maturation - Mus musculus (mouse), Prolactin signaling pathway - Mus musculus (mouse), Prostate cancer - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RAC1 GTPase cycle, RAC2 GTPase cycle, RAF/MAP kinase cascade, RET signaling, RHO GTPase cycle, Rap1 signaling pathway - Mus musculus (mouse), Ras signaling pathway - Mus musculus (mouse), Regulation of T cell activation by CD28 family, Regulation of actin cytoskeleton - Mus musculus (mouse), Regulation of lipolysis in adipocytes - Mus musculus (mouse), Regulation of signaling by CBL, Relaxin signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Role of LAT2/NTAL/LAB on calcium mobilization, Role of phospholipids in phagocytosis, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by ALK, Signaling by EGFR, Signaling by ERBB2, Signaling by ERBB4, Signaling by Erythropoietin, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by GPCR, Signaling by Insulin receptor, Signaling by Interleukins, Signaling by LTK, Signaling by MET, Signaling by NTRK1 (TRKA), Signaling by NTRKs, Signaling by Nuclear Receptors, Signaling by PDGF, Signaling by Receptor Tyrosine Kinases, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Signaling by SCF-KIT, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), Signaling by VEGF, Signaling pathways regulating pluripotency of stem cells - Mus musculus (mouse), Small cell lung cancer - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), Synthesis of PIPs at the plasma membrane, T cell receptor signaling pathway - Mus musculus (mouse), TCR signaling, TNF signaling pathway - Mus musculus (mouse), Thyroid hormone signaling pathway - Mus musculus (mouse), Tie2 Signaling, Toll-like receptor signaling pathway - Mus musculus (mouse), Type II diabetes mellitus - Mus musculus (mouse), VEGF signaling pathway - Mus musculus (mouse), VEGFA-VEGFR2 Pathway, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse), cAMP signaling pathway - Mus musculus (mouse), mTOR signaling pathway - Mus musculus (mouse)
UniProt: P42337
Entrez ID: 18706
|
Does Knockout of Serpina10 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Serpina10
|
response to bacteria
|
renal medulla cell line
|
Gene: Serpina10 (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10)
Type: protein-coding
Summary: The protein encoded by this gene is a member of the large serpin family of proteins, and is also known as serpin PZ-dependent protease inhibitor (ZPI or PZI). This protein is thought to play an important role in the regulation of coagulation. It directly inhibits factor XIa, and also inhibits factor Xa in the presence of calcium, phospholipids, and protein Z (PZ). Deficiencies in this gene lead to an increase in thrombosis. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms. [provided by RefSeq, Aug 2014].
Gene Ontology: BP: blood coagulation, hemostasis, liver regeneration; MF: heparin binding, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity; CC: extracellular region, extracellular space
Pathways: Metabolism of proteins, Post-translational protein modification, Post-translational protein phosphorylation, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
UniProt: Q8R121
Entrez ID: 217847
|
Does Knockout of Pcdhb21 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Pcdhb21
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Pcdhb21 (protocadherin beta 21)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell adhesion, homophilic cell adhesion via plasma membrane adhesion molecules; MF: calcium ion binding, cell adhesion molecule binding, molecular_function; CC: membrane, plasma membrane
Pathways:
UniProt: Q91V48
Entrez ID: 93892
|
Does Knockout of P2rx3 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
P2rx3
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: P2rx3 (purinergic receptor P2X, ligand-gated ion channel, 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: behavioral response to formalin induced pain, behavioral response to pain, calcium ion transmembrane transport, cellular response to ATP, chemical synaptic transmission, establishment of localization in cell, excitatory postsynaptic potential, inorganic cation transmembrane transport, modulation of chemical synaptic transmission, monoatomic cation transmembrane transport, monoatomic cation transport, monoatomic ion transmembrane transport, monoatomic ion transport, neuromuscular synaptic transmission, neuronal action potential, peristalsis, protein homotrimerization, purinergic nucleotide receptor signaling pathway, regulation of synaptic plasticity, response to ATP, response to carbohydrate, response to cold, response to heat, response to hypoxia, response to mechanical stimulus, response to temperature stimulus, sensory perception of taste, urinary bladder smooth muscle contraction; MF: ATP binding, extracellularly ATP-gated monoatomic cation channel activity, identical protein binding, metal ion binding, monoatomic ion channel activity, nucleotide binding, purinergic nucleotide receptor activity; CC: Schaffer collateral - CA1 synapse, axon, dendritic spine, hippocampal mossy fiber to CA3 synapse, membrane, neuron projection, neuronal cell body, plasma membrane, postsynapse, presynaptic membrane, receptor complex, terminal bouton
Pathways: Calcium signaling pathway - Mus musculus (mouse), Elevation of cytosolic Ca2+ levels, Hemostasis, Neuroactive ligand-receptor interaction - Mus musculus (mouse), Platelet calcium homeostasis, Platelet homeostasis, Taste transduction - Mus musculus (mouse)
UniProt: Q3UR32
Entrez ID: 228139
|
Does Knockout of Tmem156 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Tmem156
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tmem156 (transmembrane protein 156)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: A0A1D5RLR8, A0A1D5RLB5, D3Z447, A0A1D5RM02
Entrez ID: 243025
|
Does Knockout of Plac8l1 in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Plac8l1
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Plac8l1 (PLAC8-like 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q08EJ0
Entrez ID: 69401
|
Does Knockout of Dtd1 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Dtd1
|
cell cycle progression
|
breast epithelium
|
Gene: Dtd1 (D-tyrosyl-tRNA deacylase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA replication, aminoacyl-tRNA metabolism involved in translational fidelity, tRNA metabolic process; MF: D-aminoacyl-tRNA deacylase activity, D-tyrosyl-tRNA(Tyr) deacylase activity, DNA binding, Gly-tRNA(Ala) deacylase activity, RNA binding, aminoacyl-tRNA deacylase activity, hydrolase activity, metal ion binding, tRNA binding; CC: cytoplasm, nucleus
Pathways:
UniProt: Q9DD18
Entrez ID: 66044
|
Does Knockout of Vmn1r79 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,679
|
Knockout
|
Vmn1r79
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Vmn1r79 (vomeronasal 1 receptor 79)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, biological_process, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, molecular_function, pheromone binding, pheromone receptor activity; CC: cellular_component, membrane, plasma membrane
Pathways:
UniProt: Q8R285
Entrez ID: 100042437
|
Does Knockout of Prep in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Prep
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Prep (prolyl endopeptidase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiotensin maturation, protein catabolic process, proteolysis; MF: endopeptidase activity, hydrolase activity, metallocarboxypeptidase activity, oligopeptidase activity, peptidase activity, peptide binding, serine-type endopeptidase activity, serine-type peptidase activity; CC: cytoplasm, cytosol, extracellular region, nucleus
Pathways: Renin-angiotensin system - Mus musculus (mouse)
UniProt: Q9QUR6
Entrez ID: 19072
|
Does Knockout of 4930523C07Rik in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
4930523C07Rik
|
cell proliferation
|
Melanoma Cell Line
|
Gene: 4930523C07Rik (RIKEN cDNA 4930523C07 gene)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: Q8CE67, E9Q2T4
Entrez ID: 67647
|
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