prompt string | hit int64 | screen_id int64 | crispr_strategy string | gene string | phenotype string | cell_type string | gene_context string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ghsr in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,263 | Knockout | Ghsr | cell proliferation | Colonic Cancer Cell Line | Gene: Ghsr (growth hormone secretagogue receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, G protein-coupled receptor signaling pathway, actin polymerization or depolymerization, adult feeding behavior, cellular response ... |
Does Knockout of Cav2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Cav2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Cav2 (caveolin 2)
Type: protein-coding
Summary: This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize tog... |
Does Knockout of Riok2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,171 | Knockout | Riok2 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Riok2 (RIO kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA, positive regulation of rRNA processing, positive regulation of ribosomal small subunit export from nucleus, protein autophosphorylation, regulation of mitotic metaphase/anap... |
Does Knockout of Tvp23b in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Tvp23b | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Tvp23b (trans-golgi network vesicle protein 23B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein secretion, vesicle-mediated transport; CC: Golgi membrane, membrane
Pathways:
UniProt: Q9D8T4
Entrez ID: 67510 |
Does Knockout of Qrich2 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Qrich2 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Qrich2 (glutamine rich 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection assembly, flagellated sperm motility, negative regulation of ubiquitin-dependent protein catabolic process; CC: cell projection, cilium, cytoplasm, membrane, motile cilium, nuc... |
Does Knockout of Sub1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 83 | Knockout | Sub1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Sub1 (SUB1 homolog, transcriptional regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, negative regulation of DNA metabolic process, positive regulation of transcription initiation by RNA polymerase II, protein homooligo... |
Does Knockout of Dach1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Dach1 | cell proliferation | Melanoma Cell Line | Gene: Dach1 (dachshund family transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: development of primary female sexual characteristics, epithelial cell proliferation, negative regulation of DNA biosynthetic process, negative regulation of DNA-templated... |
Does Knockout of Vmn1r47 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 578 | Knockout | Vmn1r47 | cell proliferation | Embryonic Stem Cell Line | Gene: Vmn1r47 (vomeronasal 1 receptor 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone ... |
Does Knockout of Rasgef1a in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Rasgef1a | protein/peptide accumulation | Regulatory T cell | Gene: Rasgef1a (RasGEF domain family, member 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Signal Transduction
UniProt: A0A0N4SVF2, A6H650, A0A0N4SVR5, Q3TYC0
... |
Does Knockout of Mrpl32 in Melanoma Cell Line causally result in protein/peptide accumulation? | 0 | 1,839 | Knockout | Mrpl32 | protein/peptide accumulation | Melanoma Cell Line | Gene: Mrpl32 (mitochondrial ribosomal protein L32)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, ... |
Does Knockout of Rint1 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Rint1 | protein/peptide accumulation | Microglial Cell Line | Gene: Rint1 (RAD50 interactor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, mitotic G2 DNA damage checkpoint signaling, protein transport, regulation of ER to Golgi vesicle-mediated transport, retrograde vesi... |
Does Knockout of Usp32 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Usp32 | response to virus | Embryonic Fibroblast Cell Line | Gene: Usp32 (ubiquitin specific peptidase 32)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of TORC1 signaling, protein deubiquitination, proteolysis; MF: calcium ion binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, h... |
Does Knockout of Dlgap3 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Dlgap3 | phagocytosis | macrophage | Gene: Dlgap3 (DLG associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: modification of postsynaptic structure, modulation of chemical synaptic transmission, protein-containing complex assembly, signaling; MF: PDZ domain binding, amyloid-beta binding, mole... |
Does Knockout of Zmynd11 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | Zmynd11 | protein/peptide distribution | myoblast cell line | Gene: Zmynd11 (zinc finger, MYND domain containing 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, defense response to virus, negative regulation of DNA-templated transcription, negative regulation of JNK cascade, negative regulation of canonic... |
Does Knockout of Cnnm2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Cnnm2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Cnnm2 (cyclin M2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: magnesium ion homeostasis, magnesium ion transmembrane transport, magnesium ion transport, monoatomic ion transport; MF: ATP binding, magnesium ion transmembrane transporter activity; CC: basolateral ... |
Does Knockout of Vmn1r233 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,265 | Knockout | Vmn1r233 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Vmn1r233 (vomeronasal 1 receptor 233)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromon... |
Does Knockout of Stx18 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 84 | Knockout | Stx18 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Stx18 (syntaxin 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum membrane organization, intracellular protein transport, membrane fusion, positive regulation of ER to Golgi vesicle-mediated transport, positive regulation of organelle assembl... |
Does Knockout of Car1 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,682 | Knockout | Car1 | protein/peptide distribution | myoblast cell line | Gene: Car1 (carbonic anhydrase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: arylesterase activity, carbonate dehydratase activity, cyanamide hydratase activity, hydro-lyase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytoplasm
Pathway... |
Does Knockout of Map3k6 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Map3k6 | cell proliferation | Mouse kidney carcinoma cell | Gene: Map3k6 (mitogen-activated protein kinase kinase kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, MAPK cascade, p38MAPK cascade; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, magnesium ion binding, metal ion binding, nucle... |
Does Knockout of Klhl7 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,685 | Knockout | Klhl7 | protein/peptide distribution | myoblast cell line | Gene: Klhl7 (kelch-like 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination; MF: identical protein binding, protein homodimerization activity, ubiquitin-like ligase-substrate adaptor ... |
Does Knockout of Dnmt3a in Colonic Cancer Cell Line causally result in cell proliferation? | 0 | 1,276 | Knockout | Dnmt3a | cell proliferation | Colonic Cancer Cell Line | Gene: Dnmt3a (DNA methyltransferase 3A)
Type: protein-coding
Summary: This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple diffe... |
Does Knockout of Gab1 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Gab1 | cell proliferation | Regulatory T cell | Gene: Gab1 (growth factor receptor bound protein 2-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cellular response to vascular endothelial growth factor stimulus, endothelial cell chemotaxis, epidermal growth factor receptor signaling... |
Does Knockout of Foxn3 in macrophage causally result in phagocytosis? | 0 | 1,888 | Knockout | Foxn3 | phagocytosis | macrophage | Gene: Foxn3 (forkhead box N3)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within craniofacial suture morphogenesis. Predicted to be active in nucleus. Is expressed in sev... |
Does Knockout of Emb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Emb | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Emb (embigin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell adhesion, dendrite self-avoidance, homophilic cell adhesion via plasma membrane adhesion molecules, plasma membrane lactate transport; CC: axon, membrane, plasma membrane, synapse
... |
Does Knockout of Scn10a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 688 | Knockout | Scn10a | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Scn10a (sodium channel, voltage-gated, type X, alpha)
Type: protein-coding
Summary: Enables voltage-gated sodium channel activity. Involved in behavioral response to pain; circadian rhythm; and detection of stimulus involved in sensory perception. Acts upstream of or within several processes, incl... |
Does Knockout of Swap70 in Lymphoma Cell Line causally result in response to chemicals? | 0 | 1,554 | Knockout | Swap70 | response to chemicals | Lymphoma Cell Line | Gene: Swap70 (SWA-70 protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle assembly, isotype switching, negative regulation of actin filament depolymerization, negative regulation of cell-cell adhesion mediated by integrin, positive regulation of ... |
Does Knockout of Slc35f4 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Slc35f4 | response to virus | Microglial Cell Line | Gene: Slc35f4 (solute carrier family 35, member F4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8BZK4
Entrez ID: 75288 |
Does Knockout of Clpx in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Clpx | cell proliferation | Mouse kidney carcinoma cell | Gene: Clpx (caseinolytic mitochondrial matrix peptidase chaperone subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, protein folding, proteolysis, proteolysis involved in protein catabolic process; MF: ATP binding, ATP hydrolysis activity, ATP... |
Does Knockout of Olfml2a in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,290 | Knockout | Olfml2a | cell proliferation | Mouse kidney carcinoma cell | Gene: Olfml2a (olfactomedin-like 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extracellular matrix organization, signal transduction; MF: extracellular matrix binding, identical protein binding; CC: extracellular matrix, extracellular region, extracellular space
... |
Does Knockout of Cped1 in renal medulla cell line causally result in response to bacteria? | 0 | 2,049 | Knockout | Cped1 | response to bacteria | renal medulla cell line | Gene: Cped1 (cadherin-like and PC-esterase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endoplasmic reticulum
Pathways:
UniProt: A0A2Z4MSG2, B2RX70, D3YUQ2, E9Q7L8, S4R2A1
Entrez ID: 214642 |
Does Knockout of Megf6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 1,130 | Knockout | Megf6 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Megf6 (multiple EGF-like-domains 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, vesicle-mediated transport; MF: calcium ion binding, molecular_function, scavenger receptor activity; CC: extracellular matrix, extracellular region
Path... |
Does Knockout of Tcea3 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,288 | Knockout | Tcea3 | cell proliferation | Mouse kidney carcinoma cell | Gene: Tcea3 (transcription elongation factor A (SII), 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: DNA binding, metal ion binding, nucle... |
Does Knockout of Baiap2l2 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Baiap2l2 | response to virus | Microglial Cell Line | Gene: Baiap2l2 (BAI1-associated protein 2-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin crosslink formation, actin filament bundle assembly, membrane organization, plasma membrane organization, positive regulation of actin filament polymerization; MF: iden... |
Does Knockout of Commd7 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,289 | Knockout | Commd7 | cell proliferation | Mouse kidney carcinoma cell | Gene: Commd7 (COMM domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, tumor necrosis factor-mediated signaling pathway; MF: NF-kappaB binding
Pathways: Metabolism of proteins, Neddylation, Post... |
Does Knockout of Vamp7 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Vamp7 | response to virus | Embryonic Fibroblast Cell Line | Gene: Vamp7 (vesicle-associated membrane protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi vesicle transport, SNARE complex assembly, calcium-ion regulated exocytosis, chylomicron assembly, endoplasmic reticulum t... |
Does Knockout of Agxt2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,175 | Knockout | Agxt2 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Agxt2 (alanine-glyoxylate aminotransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alanine catabolic process, by transamination, N(omega),N(omega)-dimethyl-L-arginine catabolic process, glycine biosynthetic process, by transamination of glyoxylate, glyo... |
Does Knockout of Lingo2 in Embryonic Fibroblast Cell Line causally result in cell proliferation? | 0 | 345 | Knockout | Lingo2 | cell proliferation | Embryonic Fibroblast Cell Line | Gene: Lingo2 (leucine rich repeat and Ig domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of synapse assembly, regulation of nervous system development; MF: molecular_function, signaling receptor activity; CC: glutamatergic synapse,... |
Does Knockout of Uri1 in macrophage causally result in response to bacteria? | 0 | 2,211 | Knockout | Uri1 | response to bacteria | macrophage | Gene: Uri1 (URI1, prefoldin-like chaperone)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to growth factor stimulus, cellular response to steroid hormone stimulus, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, n... |
Does Knockout of Mir338 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Mir338 | cell cycle progression | breast epithelium | Gene: Mir338 (microRNA 338)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase I... |
Does Knockout of Rcc1l in Embryonic Stem Cell Line causally result in cell proliferation? | 1 | 579 | Knockout | Rcc1l | cell proliferation | Embryonic Stem Cell Line | Gene: Rcc1l (reculator of chromosome condensation 1 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial fusion, mitochondrial large ribosomal subunit assembly, mitochondrial small ribosomal subunit assembly; MF: guanyl-nucleotide exchange factor activity, ... |
Does Knockout of Pgm1 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | Pgm1 | response to virus | Microglial Cell Line | Gene: Pgm1 (phosphoglucomutase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, galactose catabolic process via UDP-galactose, Leloir pathway, glucose metabolic process, glycogen biosynthetic process, glycogen catabolic process; MF: intra... |
Does Knockout of Cyp2d12 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,274 | Knockout | Cyp2d12 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Cyp2d12 (cytochrome P450, family 2, subfamily d, polypeptide 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, xenobiotic metabolic process; MF: anandamide 11,12 epoxidase activity, anandamide 14,15 epoxidase activity, anandamide 8,... |
Does Knockout of Zfp746 in breast epithelium causally result in cell cycle progression? | 0 | 1,468 | Knockout | Zfp746 | cell cycle progression | breast epithelium | Gene: Zfp746 (zinc finger protein 746)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, protein heteroo... |
Does Knockout of Prkd2 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Prkd2 | protein/peptide accumulation | Regulatory T cell | Gene: Prkd2 (protein kinase D2)
Type: protein-coding
Summary: Predicted to enable protein kinase C binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in positive regulation of macromolecule biosynthetic process and positive regulation of signal trans... |
Does Knockout of Klf7 in macrophage causally result in phagocytosis? | 0 | 1,889 | Knockout | Klf7 | phagocytosis | macrophage | Gene: Klf7 (Kruppel-like transcription factor 7 (ubiquitous))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, axonogenesis, dendrite morphogenesis, glucose homeostasis, negative regulation of adipose tissue development, negative regulation of insulin secret... |
Does Knockout of Prrt2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,284 | Knockout | Prrt2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Prrt2 (proline-rich transmembrane protein 2)
Type: protein-coding
Summary: Enables syntaxin-1 binding activity. Involved in negative regulation of short-term synaptic potentiation; regulation of vesicle fusion; and synaptic vesicle fusion to presynaptic active zone membrane. Located in axon termin... |
Does Knockout of Tmed5 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,269 | Knockout | Tmed5 | cell proliferation | Melanoma Cell Line | Gene: Tmed5 (transmembrane p24 trafficking protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi ribbon formation, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport; CC: COPII-coated ER to Golgi transp... |
Does Knockout of Ankrd7 in Microglial Cell Line causally result in protein/peptide accumulation? | 0 | 1,399 | Knockout | Ankrd7 | protein/peptide accumulation | Microglial Cell Line | Gene: Ankrd7 (ankyrin repeat domain 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, nucleoplasm, nucleus
Pathways:
UniProt: Q9D504
Entrez ID: 75196 |
Does Knockout of Fh1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,272 | Knockout | Fh1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Fh1 (fumarate hydratase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, arginine metabolic process, fumarate metabolic process, homeostasis of number of cells within a tissue, malate metabolic process, positive regulation of cold-... |
Does Knockout of Lmcd1 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,281 | Knockout | Lmcd1 | cell proliferation | Melanoma Cell Line | Gene: Lmcd1 (LIM and cysteine-rich domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of calcineurin-NFAT signaling cascade, regulation of cardiac muscle hypertrophy; MF: metal ion bind... |
Does Knockout of Cyp2c37 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Cyp2c37 | response to virus | Embryonic Fibroblast Cell Line | Gene: Cyp2c37 (cytochrome P450, family 2. subfamily c, polypeptide 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, epoxygenase P450 pathway, lipid metabolic process, xenobiotic catabolic process; MF: arachidonate epoxygenase activity, a... |
Does Knockout of Stx12 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,280 | Knockout | Stx12 | cell proliferation | Colonic Adenocarcinoma Cell Line | Gene: Stx12 (syntaxin 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, cholesterol efflux, endocytic recycling, intracellular protein transport, organelle fusion, protein stabilization, protein transport, regulation of biological quality, regula... |
Does Knockout of Zfp281 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 161 | Knockout | Zfp281 | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Zfp281 (zinc finger protein 281)
Type: protein-coding
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic body morphogenesis and stem cell differentiation... |
Does Knockout of Retn in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,565 | Knockout | Retn | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Retn (resistin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fat cell differentiation, negative regulation of feeding behavior, positive regulation of collagen metabolic process, positive regulation of progesterone secretion, positive regulation of smooth muscle ... |
Does Knockout of Atxn7 in Embryonic Cell Line causally result in protein/peptide accumulation? | 0 | 1,152 | Knockout | Atxn7 | protein/peptide accumulation | Embryonic Cell Line | Gene: Atxn7 (ataxin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of microtubule depolymerization, positive regulation of DNA-temp... |
Does Knockout of Phyhd1 in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,682 | Knockout | Phyhd1 | protein/peptide distribution | myoblast cell line | Gene: Phyhd1 (phytanoyl-CoA dioxygenase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 2-oxoglutarate-dependent dioxygenase activity, dioxygenase activity, metal ion binding, oxidoreductase activity
Pathways:
UniProt: Q9DB26
... |
Does Knockout of Lonrf2 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,287 | Knockout | Lonrf2 | cell proliferation | Mouse kidney carcinoma cell | Gene: Lonrf2 (LON peptidase N-terminal domain and ring finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: motor behavior, negative regulation of neuron apoptotic process, neuromuscular process, neuron apoptotic process, neuron projection development, protein qualit... |
Does Knockout of Dnajc2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity? | 0 | 2,172 | Knockout | Dnajc2 | tumorigenicity | Breast Adenocarcinoma Cell Line | Gene: Dnajc2 (DnaJ heat shock protein family (Hsp40) member C2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' cotranslational protein folding, DNA replication, chromatin organization, negative regulation of DNA biosynthetic process, negative regulation of cell... |
Does Knockout of Pcsk1n in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Pcsk1n | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Pcsk1n (proprotein convertase subtilisin/kexin type 1 inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuropeptide signaling pathway, peptide hormone processing, response to cold, response to dietary excess; MF: endopeptidase inhibitor activity, protein b... |
Does Knockout of Rtp2 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Rtp2 | response to virus | Microglial Cell Line | Gene: Rtp2 (receptor transporter protein 2)
Type: protein-coding
Summary: Predicted to enable olfactory receptor binding activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste; protein insertion into membrane; and protein targeting to membrane... |
Does Knockout of Dkk4 in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,680 | Knockout | Dkk4 | protein/peptide distribution | myoblast cell line | Gene: Dkk4 (dickkopf WNT signaling pathway inhibitor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of hair follicle placod... |
Does Knockout of Mpv17l in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,684 | Knockout | Mpv17l | protein/peptide distribution | myoblast cell line | Gene: Mpv17l (Mpv17 transgene, kidney disease mutant-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of hydrogen peroxide biosynthetic process, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling p... |
Does Knockout of Gab3 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,260 | Knockout | Gab3 | cell proliferation | Mouse kidney carcinoma cell | Gene: Gab3 (growth factor receptor bound protein 2-associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: macrophage differentiation, signal transduction; MF: protein binding, signaling adaptor activity; CC: cellular_component, cytoplasm, cytosol
P... |
Does Knockout of Oosp3 in Embryonic Stem Cell Line causally result in cell proliferation? | 0 | 579 | Knockout | Oosp3 | cell proliferation | Embryonic Stem Cell Line | Gene: Oosp3 (oocyte secreted protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: G5E8D7
Entrez ID: 225923 |
Does Knockout of Rfc2 in Regulatory T cell causally result in cell proliferation? | 0 | 1,484 | Knockout | Rfc2 | cell proliferation | Regulatory T cell | Gene: Rfc2 (replication factor C (activator 1) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding... |
Does Knockout of Traf2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,261 | Knockout | Traf2 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Traf2 (TNF receptor-associated factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD27 signaling pathway, CD40 signaling pathway, T cell activation, TORC1 complex assembly, TORC1 signaling, TORC2 complex disassembly, TORC2 signaling, apoptotic process, cellul... |
Does Knockout of Stkld1 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Stkld1 | cell proliferation | Regulatory T cell | Gene: Stkld1 (serine/threonine kinase-like domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity
Pathways:
UniProt: Q80YS9
Entrez I... |
Does Knockout of Mettl13 in macrophage causally result in phagocytosis? | 0 | 1,890 | Knockout | Mettl13 | phagocytosis | macrophage | Gene: Mettl13 (methyltransferase 13, eEF1A lysine and N-terminal methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: catalytic activity, methyltransferase activity, molecular_function, protein-lysine N-methyltransferase activity, transferase activity; CC: c... |
Does Knockout of Ppfia1 in Regulatory T cell causally result in cell proliferation? | 0 | 1,483 | Knockout | Ppfia1 | cell proliferation | Regulatory T cell | Gene: Ppfia1 (protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cortical microtubule organization, negative regulation of protein localization to plasma membrane, nega... |
Does Knockout of Mbl2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,838 | Knockout | Mbl2 | cell proliferation | Melanoma Cell Line | Gene: Mbl2 (mannose-binding lectin (protein C) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of membrane attack complex, antiviral innate immune response, cell surface pattern recognition receptor signaling pathway, complement activation, complement activa... |
Does Knockout of Cldn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 0 | 81 | Knockout | Cldn1 | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Cldn1 (claudin 1)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the parace... |
Does Knockout of Ms4a8a in Pancreatic Cancer Cell Line causally result in response to chemicals? | 0 | 2,359 | Knockout | Ms4a8a | response to chemicals | Pancreatic Cancer Cell Line | Gene: Ms4a8a (membrane-spanning 4-domains, subfamily A, member 8A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q99N10
Entrez ID: 64381 |
Does Knockout of Rassf10 in breast epithelium causally result in cell cycle progression? | 0 | 1,470 | Knockout | Rassf10 | cell cycle progression | breast epithelium | Gene: Rassf10 (Ras association (RalGDS/AF-6) domain family (N-terminal) member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development, positive regulation of neural precursor cell proliferation, positive regulation of neurogenesis, signal transduct... |
Does Knockout of Spata20 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 2,307 | Knockout | Spata20 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Spata20 (spermatogenesis associated 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cell differentiation, spermatogenesis
Pathways:
UniProt: Q80YT5
Entrez ID: 217116 |
Does Knockout of Prss45 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation? | 0 | 1,077 | Knockout | Prss45 | protein/peptide accumulation | Mouse Embryonic Stem Cell | Gene: Prss45 (serine protease 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: serine-type endopeptidase activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8K4I7
Entrez ID: 260408 |
Does Knockout of Rev3l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 81 | Knockout | Rev3l | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Rev3l (REV3 like, DNA directed polymerase zeta catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, double-strand break repair via homologous recombination, error-prone translesion synthesis, translesio... |
Does Knockout of Cyb5r4 in Neuroblastoma Cell Line causally result in response to virus? | 0 | 1,422 | Knockout | Cyb5r4 | response to virus | Neuroblastoma Cell Line | Gene: Cyb5r4 (cytochrome b5 reductase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NADP+ metabolic process, cell development, glucose homeostasis, heme metabolic process, insulin secretion, reactive oxygen species metabolic process, response to antibiotic, superoxid... |
Does Knockout of Dmpk in myoblast cell line causally result in protein/peptide distribution? | 1 | 1,679 | Knockout | Dmpk | protein/peptide distribution | myoblast cell line | Gene: Dmpk (dystrophia myotonica-protein kinase)
Type: protein-coding
Summary: The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appear... |
Does Knockout of Stx5a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation? | 1 | 82 | Knockout | Stx5a | cell proliferation | Pre-B-Lymphocyte Cell Line | Gene: Stx5a (syntaxin 5A)
Type: protein-coding
Summary: Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and regulation of Golgi organization. Predicted to act upstream of or within... |
Does Knockout of Acaa1a in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,286 | Knockout | Acaa1a | cell proliferation | Mouse kidney carcinoma cell | Gene: Acaa1a (acetyl-Coenzyme A acyltransferase 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-linolenic acid metabolic process, bile acid metabolic process, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA oxidase, fatty acid derivative bios... |
Does Knockout of Ccdc184 in Melanoma Cell Line causally result in cell proliferation? | 0 | 1,270 | Knockout | Ccdc184 | cell proliferation | Melanoma Cell Line | Gene: Ccdc184 (coiled-coil domain containing 184)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm
Pathways:
UniProt: Q8BMK5
Entrez ID: 239650 |
Does Knockout of Vash2 in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,482 | Knockout | Vash2 | protein/peptide accumulation | Regulatory T cell | Gene: Vash2 (vasohibin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, cell-cell fusion, labyrinthine layer blood vessel development, labyrinthine layer development, placenta blood vessel development, positive regulation of angiogenesis, positive regu... |
Does Knockout of Gtpbp2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,663 | Knockout | Gtpbp2 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Gtpbp2 (GTP binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, no-go decay, rescue of stalled ribosome, translational elongation; MF: GTP binding, GTPase activity, alpha-aminoacyl-tRNA binding, identical pr... |
Does Knockout of Zfp2 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,488 | Knockout | Zfp2 | cell proliferation | Melanoma Cell Line | Gene: Zfp2 (zinc finger protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Gene ex... |
Does Knockout of Zbtb2 in Mammary Gland Tumor Cell Line causally result in cell proliferation? | 0 | 1,266 | Knockout | Zbtb2 | cell proliferation | Mammary Gland Tumor Cell Line | Gene: Zbtb2 (zinc finger and BTB domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA-binding transcription repressor... |
Does Knockout of Krt79 in Melanoma Cell Line causally result in cell proliferation? | 0 | 2,492 | Knockout | Krt79 | cell proliferation | Melanoma Cell Line | Gene: Krt79 (keratin 79)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermediate filament organization, keratinization; MF: enzyme binding, structural constituent of skin epidermis; CC: intermediate filament, keratin filament
Pathways: Developmental Biology,... |
Does Knockout of H3f3a in myoblast cell line causally result in protein/peptide distribution? | 0 | 1,681 | Knockout | H3f3a | protein/peptide distribution | myoblast cell line | Gene: H3f3a (H3.3 histone A)
Type: protein-coding
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 ... |
Does Knockout of Tmem216 in Microglial Cell Line causally result in phagocytosis? | 0 | 1,587 | Knockout | Tmem216 | phagocytosis | Microglial Cell Line | Gene: Tmem216 (transmembrane protein 216)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which is involved in regulation of signaling and trafficking of associated proteins. In humans, mutations in this gene are associated with ciliopathies including Joubert, Meckel and related ... |
Does Knockout of Urgcp in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Urgcp | protein/peptide accumulation | Regulatory T cell | Gene: Urgcp (upregulator of cell proliferation)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, molecular_function, nucleotide binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q5NCI0
Entrez ID: 72046 |
Does Knockout of Ccr9 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Ccr9 | response to virus | Embryonic Fibroblast Cell Line | Gene: Ccr9 (C-C motif chemokine receptor 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, gamma-delta intraepithelial T cell differentiation, G protein-coupled receptor signaling pathway, calcium-mediated signaling, cell chemotaxis, chemokine-mediated sign... |
Does Knockout of Slc35e4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity? | 0 | 687 | Knockout | Slc35e4 | tumorigenicity | Immortal Mouse Liver-derived Cell Line | Gene: Slc35e4 (solute carrier family 35, member E4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, membrane
Pathways:
UniProt: Q8K3D6
Entrez ID: 103710 |
Does Knockout of Prok2 in Embryonic Fibroblast Cell Line causally result in response to virus? | 0 | 1,133 | Knockout | Prok2 | response to virus | Embryonic Fibroblast Cell Line | Gene: Prok2 (prokineticin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, chemotaxis, circadian rhythm, coronary vasculature development, endothelial cell proliferation, epicardium-derived cardiac endothelial cell differentiation, epicardium-derived cardi... |
Does Knockout of Csgalnact1 in Mouse kidney carcinoma cell causally result in cell proliferation? | 0 | 1,259 | Knockout | Csgalnact1 | cell proliferation | Mouse kidney carcinoma cell | Gene: Csgalnact1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1)
Type: protein-coding
Summary: Enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate proteoglycan biosynthetic process. Acts upstream of or with... |
Does Knockout of Zbed6 in Regulatory T cell causally result in cell proliferation? | 0 | 2,127 | Knockout | Zbed6 | cell proliferation | Regulatory T cell | Gene: Zbed6 (zinc finger, BED type containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst hatching, negative regulation of DNA-templated transcription, negative regulation of muscle cell differentiation, negative regulation of transcription by RNA polyme... |
Does Knockout of Tfb2m in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype? | 0 | 167 | Knockout | Tfb2m | regulation of signal transduction phenotype | Embryonic Fibroblast Cell Line | Gene: Tfb2m (transcription factor B2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, mitochondrial transcription, rRNA methylation, rRNA modification, rRNA processing, transcription initiation at mitochondrial promoter; MF: RNA binding, methyl... |
Does Knockout of Lonrf2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals? | 0 | 1,565 | Knockout | Lonrf2 | response to chemicals | Pancreatic Ductal Adenocarcinoma Cell Line | Gene: Lonrf2 (LON peptidase N-terminal domain and ring finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: motor behavior, negative regulation of neuron apoptotic process, neuromuscular process, neuron apoptotic process, neuron projection development, protein qualit... |
Does Knockout of Stard8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation? | 0 | 1,277 | Knockout | Stard8 | cell proliferation | Breast Adenocarcinoma Cell Line | Gene: Stard8 (StAR related lipid transfer domain containing 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, regulation of Rho protein signal transduction, signal transduction; MF: GTPase activator activity, lipid binding; CC: anchoring ... |
Does Knockout of N6amt1 in Microglial Cell Line causally result in response to virus? | 0 | 2,429 | Knockout | N6amt1 | response to virus | Microglial Cell Line | Gene: N6amt1 (N-6 adenine-specific DNA methyltransferase 1 (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arsonoacetate metabolic process, chromatin organization, methylation, negative regulation of gene expression, epigenetic, peptidyl-glutamine methylation,... |
Does Knockout of Hbp1 in Microglial Cell Line causally result in response to virus? | 0 | 1,439 | Knockout | Hbp1 | response to virus | Microglial Cell Line | Gene: Hbp1 (high mobility group box transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of lipid transport, negative regulation of macrophage derived foam cell differentiation, negative regulation of reactive ... |
Does Knockout of Ppib in Regulatory T cell causally result in protein/peptide accumulation? | 0 | 1,481 | Knockout | Ppib | protein/peptide accumulation | Regulatory T cell | Gene: Ppib (peptidylprolyl isomerase B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone development, host-mediated activation of viral genome replication, host-mediated activation of viral process, neutrophil chemotaxis, positive regulation of multicellular organism ... |
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