prompt
string | hit
int64 | screen_id
int64 | crispr_strategy
string | gene
string | phenotype
string | cell_type
string | gene_context
string |
|---|---|---|---|---|---|---|---|
Does Knockout of Ghsr in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,263
|
Knockout
|
Ghsr
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Ghsr (growth hormone secretagogue receptor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor internalization, G protein-coupled receptor signaling pathway, actin polymerization or depolymerization, adult feeding behavior, cellular response to hormone stimulus, cellular response to insulin stimulus, cellular response to insulin-like growth factor stimulus, cellular response to lipopolysaccharide, cellular response to thyroid hormone stimulus, decidualization, female pregnancy, ghrelin secretion, growth hormone secretion, hormone-mediated signaling pathway, learning or memory, negative regulation of appetite, negative regulation of inflammatory response, negative regulation of insulin secretion, negative regulation of interleukin-1 beta production, negative regulation of interleukin-6 production, negative regulation of locomotion involved in locomotory behavior, negative regulation of macrophage apoptotic process, negative regulation of norepinephrine secretion, negative regulation of tumor necrosis factor production, peptide hormone secretion, positive regulation of appetite, positive regulation of eating behavior, positive regulation of fatty acid metabolic process, positive regulation of growth, positive regulation of insulin-like growth factor receptor signaling pathway, positive regulation of multicellular organism growth, positive regulation of small intestinal transit, positive regulation of small intestine smooth muscle contraction, positive regulation of sprouting angiogenesis, positive regulation of vascular endothelial cell proliferation, postsynaptic modulation of chemical synaptic transmission, regulation of appetite, regulation of feeding behavior, regulation of gastric motility, regulation of growth hormone secretion, regulation of hindgut contraction, regulation of neurotransmitter receptor localization to postsynaptic specialization membrane, regulation of postsynapse organization, regulation of response to food, regulation of synapse assembly, regulation of transmission of nerve impulse, response to L-glutamate, response to dexamethasone, response to estradiol, response to follicle-stimulating hormone, response to food, response to growth hormone, response to hormone, signal transduction, spermatogenesis; MF: G protein-coupled receptor activity, growth hormone secretagogue receptor activity, growth hormone-releasing hormone receptor activity, hormone binding, identical protein binding, peptide hormone binding; CC: Schaffer collateral - CA1 synapse, cell surface, glutamatergic synapse, membrane, membrane raft, neuron projection, plasma membrane, postsynapse, synaptic membrane
Pathways: G alpha (q) signalling events, GPCR downstream signalling, Growth hormone synthesis, secretion and action - Mus musculus (mouse), Neuroactive ligand-receptor interaction - Mus musculus (mouse), Signal Transduction, Signaling by GPCR, cAMP signaling pathway - Mus musculus (mouse)
UniProt: Q99P50
Entrez ID: 208188
|
Does Knockout of Cav2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Cav2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Cav2 (caveolin 2)
Type: protein-coding
Summary: This gene belongs to the caveolin family whose members encode the major protein components of caveolae, which are invaginations of plasma membrane. This gene is located adjacent to caveolin-1 and the proteins coexpressed by the two genes localize together in caveolae, where they form hetero-oligomers. The encoded protein may be involved in diverse cellular functions including proliferation, differentiation, endocytosis and trafficking. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: G protein-coupled receptor signaling pathway, basement membrane organization, caveola assembly, cell differentiation, chemical synaptic transmission, endocytosis, endoplasmic reticulum organization, host-mediated activation of viral process, insulin receptor signaling pathway, mitochondrion organization, negative regulation of endothelial cell proliferation, negative regulation of skeletal muscle cell proliferation, negative regulation of transforming growth factor beta receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of dopamine receptor signaling pathway, positive regulation of endothelial cell proliferation, positive regulation of protein localization to nucleus, receptor-mediated endocytosis of virus by host cell, regulation of cytosolic calcium ion concentration, regulation of mitotic nuclear division, skeletal muscle fiber development, vesicle docking, vesicle fusion, vesicle organization, viral release from host cell; MF: D1 dopamine receptor binding, SNARE binding, heterotrimeric G-protein binding, mitogen-activated protein kinase kinase kinase binding, molecular adaptor activity, phosphoprotein binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein kinase binding, protein-macromolecule adaptor activity, scaffold protein binding, syntaxin binding; CC: Golgi apparatus, Golgi membrane, acrosomal membrane, caveola, caveolar macromolecular signaling complex, cell surface, cytoplasm, cytoplasmic vesicle, focal adhesion, lipid droplet, membrane, membrane raft, nuclear envelope, nuclear inner membrane, nucleus, perinuclear region of cytoplasm, plasma membrane, plasma membrane raft, protein-containing complex, transport vesicle
Pathways: Bacterial invasion of epithelial cells - Mus musculus (mouse), ESR-mediated signaling, Endocytosis - Mus musculus (mouse), Extra-nuclear estrogen signaling, Fluid shear stress and atherosclerosis - Mus musculus (mouse), Focal adhesion - Mus musculus (mouse), Prion disease - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), Signal Transduction, Signaling by Nuclear Receptors
UniProt: Q9WVC3
Entrez ID: 12390
|
Does Knockout of Riok2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,171
|
Knockout
|
Riok2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Riok2 (RIO kinase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: maturation of SSU-rRNA, positive regulation of rRNA processing, positive regulation of ribosomal small subunit export from nucleus, protein autophosphorylation, regulation of mitotic metaphase/anaphase transition, ribosomal small subunit biogenesis, ribosome biogenesis; MF: ATP binding, catalytic activity, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, nucleus, preribosome, small subunit precursor
Pathways: Major pathway of rRNA processing in the nucleolus and cytosol, Metabolism of RNA, Ribosome biogenesis in eukaryotes - Mus musculus (mouse), rRNA processing, rRNA processing in the nucleus and cytosol
UniProt: Q9CQS5
Entrez ID: 67045
|
Does Knockout of Tvp23b in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Tvp23b
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Tvp23b (trans-golgi network vesicle protein 23B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: protein secretion, vesicle-mediated transport; CC: Golgi membrane, membrane
Pathways:
UniProt: Q9D8T4
Entrez ID: 67510
|
Does Knockout of Qrich2 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Qrich2
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Qrich2 (glutamine rich 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cell projection assembly, flagellated sperm motility, negative regulation of ubiquitin-dependent protein catabolic process; CC: cell projection, cilium, cytoplasm, membrane, motile cilium, nuclear membrane, nucleus, sperm flagellum
Pathways:
UniProt: Q3V2A7
Entrez ID: 217341
|
Does Knockout of Sub1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 83
|
Knockout
|
Sub1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Sub1 (SUB1 homolog, transcriptional regulator)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: RNA polymerase II promoter clearance, negative regulation of DNA metabolic process, positive regulation of transcription initiation by RNA polymerase II, protein homooligomerization, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA helicase activity, DNA-binding transcription factor binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, double-stranded DNA binding, identical protein binding, single-stranded DNA binding, transcription coactivator activity; CC: nucleolus, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: P11031
Entrez ID: 20024
|
Does Knockout of Dach1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Dach1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Dach1 (dachshund family transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: development of primary female sexual characteristics, epithelial cell proliferation, negative regulation of DNA biosynthetic process, negative regulation of DNA-templated transcription, negative regulation of cell migration, negative regulation of cell proliferation involved in contact inhibition, negative regulation of fibroblast proliferation, negative regulation of transcription by RNA polymerase II, negative regulation of transcription by competitive promoter binding, regulation of DNA-templated transcription, regulation of nuclear cell cycle DNA replication, regulation of transcription by RNA polymerase II, respiratory gaseous exchange by respiratory system, suckling behavior, type B pancreatic cell proliferation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, protein binding; CC: Golgi apparatus, cytoplasm, cytosol, nuclear speck, nucleoplasm, nucleus, transcription regulator complex
Pathways:
UniProt: Q9QYB2
Entrez ID: 13134
|
Does Knockout of Vmn1r47 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 578
|
Knockout
|
Vmn1r47
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Vmn1r47 (vomeronasal 1 receptor 47)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q9EQ51
Entrez ID: 113846
|
Does Knockout of Rasgef1a in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Rasgef1a
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Rasgef1a (RasGEF domain family, member 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways: MAPK family signaling cascades, MAPK1/MAPK3 signaling, RAF/MAP kinase cascade, Signal Transduction
UniProt: A0A0N4SVF2, A6H650, A0A0N4SVR5, Q3TYC0
Entrez ID: 70727
|
Does Knockout of Mrpl32 in Melanoma Cell Line causally result in protein/peptide accumulation?
| 0
| 1,839
|
Knockout
|
Mrpl32
|
protein/peptide accumulation
|
Melanoma Cell Line
|
Gene: Mrpl32 (mitochondrial ribosomal protein L32)
Type: protein-coding
Summary: Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL32 (mitochondrial ribosomal protein L32). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: mitochondrial translation, translation; MF: metal ion binding, structural constituent of ribosome; CC: cytosol, large ribosomal subunit, mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion, ribonucleoprotein complex, ribosome
Pathways: Metabolism of proteins, Mitochondrial protein degradation, Mitochondrial ribosome-associated quality control, Mitochondrial translation, Mitochondrial translation elongation, Mitochondrial translation termination, Ribosome - Mus musculus (mouse), Translation
UniProt: Q9DCI9
Entrez ID: 75398
|
Does Knockout of Rint1 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Rint1
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Rint1 (RAD50 interactor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum to Golgi vesicle-mediated transport, mitotic G2 DNA damage checkpoint signaling, protein transport, regulation of ER to Golgi vesicle-mediated transport, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; CC: Dsl1/NZR complex, cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Vesicle-mediated transport
UniProt: Q8BZ36
Entrez ID: 72772
|
Does Knockout of Usp32 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Usp32
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Usp32 (ubiquitin specific peptidase 32)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of TORC1 signaling, protein deubiquitination, proteolysis; MF: calcium ion binding, cysteine-type deubiquitinase activity, cysteine-type peptidase activity, hydrolase activity, metal ion binding, peptidase activity; CC: Golgi apparatus, Golgi membrane, cytoplasm, cytosol, endomembrane system, glutamatergic synapse, membrane, plasma membrane, postsynaptic density, intracellular component, recycling endosome
Pathways:
UniProt: F8VPZ3
Entrez ID: 237898
|
Does Knockout of Dlgap3 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Dlgap3
|
phagocytosis
|
macrophage
|
Gene: Dlgap3 (DLG associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: modification of postsynaptic structure, modulation of chemical synaptic transmission, protein-containing complex assembly, signaling; MF: PDZ domain binding, amyloid-beta binding, molecular adaptor activity, protein domain specific binding, scaffold protein binding; CC: cholinergic synapse, dendritic spine, glutamatergic synapse, membrane, neuromuscular junction, neuronal cell body, plasma membrane, postsynaptic density, postsynaptic specialization, synapse
Pathways: Neurexins and neuroligins, Neuronal System, Protein-protein interactions at synapses
UniProt: Q6PFD5
Entrez ID: 242667
|
Does Knockout of Zmynd11 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
Zmynd11
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Zmynd11 (zinc finger, MYND domain containing 11)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: chromatin organization, defense response to virus, negative regulation of DNA-templated transcription, negative regulation of JNK cascade, negative regulation of canonical NF-kappaB signal transduction, negative regulation of extrinsic apoptotic signaling pathway, regulation of signal transduction, regulation of transcription elongation by RNA polymerase II; MF: DNA binding, double-stranded DNA binding, histone H3K36me3 reader activity, metal ion binding, protein binding, transcription corepressor activity, zinc ion binding; CC: chromosome, nucleoplasm, nucleus
Pathways:
UniProt: Q8R5C8
Entrez ID: 66505
|
Does Knockout of Cnnm2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Cnnm2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cnnm2 (cyclin M2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: magnesium ion homeostasis, magnesium ion transmembrane transport, magnesium ion transport, monoatomic ion transport; MF: ATP binding, magnesium ion transmembrane transporter activity; CC: basolateral plasma membrane, glutamatergic synapse, membrane, plasma membrane, synapse
Pathways:
UniProt: Q3TWN3
Entrez ID: 94219
|
Does Knockout of Vmn1r233 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,265
|
Knockout
|
Vmn1r233
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Vmn1r233 (vomeronasal 1 receptor 233)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: G protein-coupled receptor signaling pathway, response to pheromone, sensory perception of chemical stimulus, signal transduction; MF: G protein-coupled receptor activity, pheromone binding, pheromone receptor activity; CC: membrane, plasma membrane
Pathways:
UniProt: Q8R294
Entrez ID: 171236
|
Does Knockout of Stx18 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 84
|
Knockout
|
Stx18
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Stx18 (syntaxin 18)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: endoplasmic reticulum membrane organization, intracellular protein transport, membrane fusion, positive regulation of ER to Golgi vesicle-mediated transport, positive regulation of organelle assembly, protein transport, regulation of Golgi organization, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle-mediated transport; MF: SNAP receptor activity, protein domain specific binding; CC: Golgi apparatus, Golgi membrane, SNARE complex, endoplasmic reticulum, endoplasmic reticulum membrane, membrane
Pathways: COPI-dependent Golgi-to-ER retrograde traffic, Golgi-to-ER retrograde transport, Intra-Golgi and retrograde Golgi-to-ER traffic, Membrane Trafficking, Phagosome - Mus musculus (mouse), SNARE interactions in vesicular transport - Mus musculus (mouse), Vesicle-mediated transport
UniProt: Q8VDS8
Entrez ID: 71116
|
Does Knockout of Car1 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,682
|
Knockout
|
Car1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Car1 (carbonic anhydrase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: arylesterase activity, carbonate dehydratase activity, cyanamide hydratase activity, hydro-lyase activity, lyase activity, metal ion binding, zinc ion binding; CC: cytoplasm
Pathways: Erythrocytes take up carbon dioxide and release oxygen, Erythrocytes take up oxygen and release carbon dioxide, Metabolism, Nitrogen metabolism - Mus musculus (mouse), O2/CO2 exchange in erythrocytes, Reversible hydration of carbon dioxide, Transport of small molecules
UniProt: P13634
Entrez ID: 12346
|
Does Knockout of Map3k6 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Map3k6
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Map3k6 (mitogen-activated protein kinase kinase kinase 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: JNK cascade, MAPK cascade, p38MAPK cascade; MF: ATP binding, MAP kinase kinase kinase activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity
Pathways: MAPK signaling pathway - Mus musculus (mouse)
UniProt: A0A0A0MQ82
Entrez ID: 53608
|
Does Knockout of Klhl7 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,685
|
Knockout
|
Klhl7
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Klhl7 (kelch-like 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteasome-mediated ubiquitin-dependent protein catabolic process, protein ubiquitination; MF: identical protein binding, protein homodimerization activity, ubiquitin-like ligase-substrate adaptor activity; CC: Cul3-RING ubiquitin ligase complex, cytoplasm, cytosol, nucleolus, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane
Pathways:
UniProt: Q8BUL5
Entrez ID: 52323
|
Does Knockout of Dnmt3a in Colonic Cancer Cell Line causally result in cell proliferation?
| 0
| 1,276
|
Knockout
|
Dnmt3a
|
cell proliferation
|
Colonic Cancer Cell Line
|
Gene: Dnmt3a (DNA methyltransferase 3A)
Type: protein-coding
Summary: This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012].
Gene Ontology: BP: DNA methylation-dependent constitutive heterochromatin formation, autosome genomic imprinting, cellular response to amino acid stimulus, cellular response to bisphenol A, cellular response to ethanol, cellular response to hypoxia, chromatin organization, developmental process involved in reproduction, epigenetic programming of gene expression, gamete generation, gene silencing by piRNA-directed DNA methylation, genomic imprinting, hepatocyte apoptotic process, heterochromatin formation, methylation, negative regulation of DNA-templated transcription, negative regulation of gene expression via chromosomal CpG island methylation, negative regulation of transcription by RNA polymerase II, neuron differentiation, oocyte development, positive regulation of cellular response to hypoxia, post-embryonic development, regulation of gene expression, regulatory ncRNA-mediated heterochromatin formation, response to cocaine, response to estradiol, response to ethanol, response to ionizing radiation, response to lead ion, response to nutrient levels, response to toxic substance, response to vitamin A, response to xenobiotic stimulus, spermatogenesis, transposable element silencing by piRNA-mediated DNA methylation; MF: DNA (cytosine-5-)-methyltransferase activity, DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates, DNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, RNA polymerase II-specific DNA-binding transcription factor binding, chromatin binding, identical protein binding, lncRNA binding, metal ion binding, methyltransferase activity, protein binding, protein-cysteine methyltransferase activity, transferase activity, unmethylated CpG binding, zinc ion binding; CC: XY body, catalytic complex, chromosome, chromosome, centromeric region, cytoplasm, euchromatin, heterochromatin, nuclear matrix, nucleoplasm, nucleus
Pathways: Cysteine and methionine metabolism - Mus musculus (mouse), MicroRNAs in cancer - Mus musculus (mouse)
UniProt: O88508
Entrez ID: 13435
|
Does Knockout of Gab1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Gab1
|
cell proliferation
|
Regulatory T cell
|
Gene: Gab1 (growth factor receptor bound protein 2-associated protein 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, cellular response to vascular endothelial growth factor stimulus, endothelial cell chemotaxis, epidermal growth factor receptor signaling pathway, epidermis development, heart development, interleukin-6-mediated signaling pathway, intracellular signal transduction, labyrinthine layer development, myoblast migration, platelet-derived growth factor receptor signaling pathway, positive regulation of MAPK cascade, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, regulation of cell migration, response to hepatocyte growth factor, response to oxidative stress, signal transduction, vascular endothelial growth factor signaling pathway; MF: protein binding, signaling adaptor activity; CC: cell cortex, cell-cell junction, cytoplasm, cytosol
Pathways: Axon guidance, Bacterial invasion of epithelial cells - Mus musculus (mouse), Developmental Biology, Downstream signaling of activated FGFR1, Downstream signaling of activated FGFR2, Downstream signaling of activated FGFR3, Downstream signaling of activated FGFR4, ErbB signaling pathway - Mus musculus (mouse), Erythropoietin activates Phosphoinositide-3-kinase (PI3K), GAB1 signalosome, Gastric cancer - Mus musculus (mouse), Hepatocellular carcinoma - Mus musculus (mouse), IGF1R signaling cascade, IRS-mediated signalling, IRS-related events triggered by IGF1R, Insulin receptor signalling cascade, Intracellular signaling by second messengers, MET activates PI3K/AKT signaling, MET activates PTPN11, MET activates RAP1 and RAC1, MET promotes cell motility, MET receptor recycling, Negative regulation of the PI3K/AKT network, Nervous system development, Neurotrophin signaling pathway - Mus musculus (mouse), PI-3K cascade:FGFR1, PI-3K cascade:FGFR2, PI-3K cascade:FGFR3, PI-3K cascade:FGFR4, PI3K Cascade, PI3K events in ERBB2 signaling, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, PIP3 activates AKT signaling, Phospholipase D signaling pathway - Mus musculus (mouse), Proteoglycans in cancer - Mus musculus (mouse), RET signaling, Ras signaling pathway - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), Signal Transduction, Signaling by EGFR, Signaling by ERBB2, Signaling by Erythropoietin, Signaling by FGFR, Signaling by FGFR1, Signaling by FGFR2, Signaling by FGFR3, Signaling by FGFR4, Signaling by Insulin receptor, Signaling by MET, Signaling by Receptor Tyrosine Kinases, Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
UniProt: Q9QYY0
Entrez ID: 14388
|
Does Knockout of Foxn3 in macrophage causally result in phagocytosis?
| 0
| 1,888
|
Knockout
|
Foxn3
|
phagocytosis
|
macrophage
|
Gene: Foxn3 (forkhead box N3)
Type: protein-coding
Summary: Predicted to enable DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within craniofacial suture morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; immune system; peripheral nervous system; and sensory organ. Orthologous to human FOXN3 (forkhead box N3). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: craniofacial suture morphogenesis, mitotic G2 DNA damage checkpoint signaling, negative regulation of DNA-templated transcription, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, cis-regulatory region sequence-specific DNA binding, sequence-specific DNA binding; CC: nucleus
Pathways:
UniProt: Q499D0
Entrez ID: 71375
|
Does Knockout of Emb in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Emb
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Emb (embigin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, cell adhesion, dendrite self-avoidance, homophilic cell adhesion via plasma membrane adhesion molecules, plasma membrane lactate transport; CC: axon, membrane, plasma membrane, synapse
Pathways: Proton-coupled monocarboxylate transport, SLC-mediated transmembrane transport, SLC-mediated transport of organic anions, Transport of small molecules
UniProt: P21995
Entrez ID: 13723
|
Does Knockout of Scn10a in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 688
|
Knockout
|
Scn10a
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Scn10a (sodium channel, voltage-gated, type X, alpha)
Type: protein-coding
Summary: Enables voltage-gated sodium channel activity. Involved in behavioral response to pain; circadian rhythm; and detection of stimulus involved in sensory perception. Acts upstream of or within several processes, including cardiac conduction; regulation of atrial cardiac muscle cell membrane depolarization; and sodium ion transport. Located in C-fiber and plasma membrane. Is expressed in brain; ganglia; and heart. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 2. Orthologous to human SCN10A (sodium voltage-gated channel alpha subunit 10). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: AV node cell action potential, behavioral response to pain, bundle of His cell action potential, cardiac conduction, circadian rhythm, detection of mechanical stimulus involved in sensory perception, detection of temperature stimulus involved in sensory perception of pain, establishment of localization in cell, membrane depolarization during action potential, membrane depolarization during cardiac muscle cell action potential, monoatomic ion transmembrane transport, monoatomic ion transport, neuronal action potential, regulation of atrial cardiac muscle cell membrane depolarization, regulation of cardiac muscle contraction, regulation of heart rate, regulation of membrane potential, regulation of monoatomic ion transmembrane transport, sensory perception of pain, sodium ion transmembrane transport, sodium ion transport, transmembrane transport; MF: monoatomic cation channel activity, monoatomic ion channel activity, sodium channel activity, transmembrane transporter binding, voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential, voltage-gated sodium channel activity, voltage-gated sodium channel activity involved in cardiac muscle cell action potential; CC: C-fiber, axon, clathrin complex, glutamatergic synapse, membrane, monoatomic ion channel complex, plasma membrane, presynaptic membrane, voltage-gated sodium channel complex
Pathways:
UniProt: Q6QIY3
Entrez ID: 20264
|
Does Knockout of Swap70 in Lymphoma Cell Line causally result in response to chemicals?
| 0
| 1,554
|
Knockout
|
Swap70
|
response to chemicals
|
Lymphoma Cell Line
|
Gene: Swap70 (SWA-70 protein)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin filament bundle assembly, isotype switching, negative regulation of actin filament depolymerization, negative regulation of cell-cell adhesion mediated by integrin, positive regulation of actin filament bundle assembly, positive regulation of cytosolic calcium ion concentration, positive regulation of mast cell chemotaxis, regulation of actin polymerization or depolymerization, regulation of protein localization, somatic cell DNA recombination; MF: ATP binding, DNA binding, protein binding; CC: actin cytoskeleton, cell projection, cytoplasm, cytoskeleton, lamellipodium, membrane, nucleus, plasma membrane, postsynapse
Pathways: RAC1 GTPase cycle, RAC2 GTPase cycle, RAC3 GTPase cycle, RHO GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q6A028
Entrez ID: 20947
|
Does Knockout of Slc35f4 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Slc35f4
|
response to virus
|
Microglial Cell Line
|
Gene: Slc35f4 (solute carrier family 35, member F4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cellular_component, membrane
Pathways:
UniProt: Q8BZK4
Entrez ID: 75288
|
Does Knockout of Clpx in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Clpx
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Clpx (caseinolytic mitochondrial matrix peptidase chaperone subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: ATP metabolic process, protein folding, proteolysis, proteolysis involved in protein catabolic process; MF: ATP binding, ATP hydrolysis activity, ATP-dependent peptidase activity, ATP-dependent protein folding chaperone, hydrolase activity, metal ion binding, nucleotide binding, peptidase activator activity, protein binding, protein dimerization activity, unfolded protein binding, zinc ion binding; CC: cytosol, endopeptidase Clp complex, mitochondrial endopeptidase Clp complex, mitochondrial inner membrane, mitochondrial matrix, mitochondrial nucleoid, mitochondrion, nucleoplasm
Pathways: Metabolism of proteins, Mitochondrial protein degradation
UniProt: Q9JHS4
Entrez ID: 270166
|
Does Knockout of Olfml2a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,290
|
Knockout
|
Olfml2a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Olfml2a (olfactomedin-like 2A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: extracellular matrix organization, signal transduction; MF: extracellular matrix binding, identical protein binding; CC: extracellular matrix, extracellular region, extracellular space
Pathways:
UniProt: Q8BHP7
Entrez ID: 241327
|
Does Knockout of Cped1 in renal medulla cell line causally result in response to bacteria?
| 0
| 2,049
|
Knockout
|
Cped1
|
response to bacteria
|
renal medulla cell line
|
Gene: Cped1 (cadherin-like and PC-esterase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: endoplasmic reticulum
Pathways:
UniProt: A0A2Z4MSG2, B2RX70, D3YUQ2, E9Q7L8, S4R2A1
Entrez ID: 214642
|
Does Knockout of Megf6 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 1,130
|
Knockout
|
Megf6
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Megf6 (multiple EGF-like-domains 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: biological_process, vesicle-mediated transport; MF: calcium ion binding, molecular_function, scavenger receptor activity; CC: extracellular matrix, extracellular region
Pathways:
UniProt: F6YCL7, A0A0A0MQ83, B1ASH4
Entrez ID: 230971
|
Does Knockout of Tcea3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,288
|
Knockout
|
Tcea3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Tcea3 (transcription elongation factor A (SII), 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA-templated transcription, regulation of transcription by RNA polymerase II, transcription elongation by RNA polymerase II; MF: DNA binding, metal ion binding, nucleic acid binding, zinc ion binding; CC: nucleus
Pathways:
UniProt: P23881
Entrez ID: 21401
|
Does Knockout of Baiap2l2 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Baiap2l2
|
response to virus
|
Microglial Cell Line
|
Gene: Baiap2l2 (BAI1-associated protein 2-like 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin crosslink formation, actin filament bundle assembly, membrane organization, plasma membrane organization, positive regulation of actin filament polymerization; MF: identical protein binding, lipid binding, phospholipid binding; CC: anchoring junction, cell-cell contact zone, clathrin complex, cytoplasmic vesicle, cytoplasmic vesicle membrane, cytosol, membrane, nucleoplasm, plasma membrane, vesicle membrane
Pathways: RHO GTPase cycle, RHOF GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q80Y61
Entrez ID: 207495
|
Does Knockout of Commd7 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,289
|
Knockout
|
Commd7
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Commd7 (COMM domain containing 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, tumor necrosis factor-mediated signaling pathway; MF: NF-kappaB binding
Pathways: Metabolism of proteins, Neddylation, Post-translational protein modification
UniProt: Q8BG94
Entrez ID: 99311
|
Does Knockout of Vamp7 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Vamp7
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Vamp7 (vesicle-associated membrane protein 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi to plasma membrane protein transport, Golgi vesicle transport, SNARE complex assembly, calcium-ion regulated exocytosis, chylomicron assembly, endoplasmic reticulum to Golgi vesicle-mediated transport, endosome to lysosome transport, eosinophil degranulation, exocytosis, natural killer cell degranulation, neutrophil degranulation, phagocytosis, engulfment, positive regulation of dendrite morphogenesis, positive regulation of histamine secretion by mast cell, protein transport, regulation of protein targeting to vacuolar membrane, synaptic vesicle exocytosis, triglyceride transport, vesicle fusion, vesicle fusion with Golgi apparatus, vesicle transport along microtubule, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding, protein binding, syntaxin binding; CC: Golgi apparatus, SNARE complex, apical part of cell, azurophil granule membrane, cell surface, cytoplasm, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, endosome, filopodium, hippocampal mossy fiber to CA3 synapse, lamellipodium, late endosome membrane, lysosomal membrane, lysosome, membrane, neuron projection, perinuclear region of cytoplasm, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, plasma membrane bounded cell projection, platelet alpha granule, pseudopodium, secretory granule, secretory granule membrane, synapse, synaptic vesicle membrane, trans-Golgi network, transport vesicle, transport vesicle membrane
Pathways: SNARE interactions in vesicular transport - Mus musculus (mouse)
UniProt: P70280
Entrez ID: 20955
|
Does Knockout of Agxt2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,175
|
Knockout
|
Agxt2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Agxt2 (alanine-glyoxylate aminotransferase 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: L-alanine catabolic process, by transamination, N(omega),N(omega)-dimethyl-L-arginine catabolic process, glycine biosynthetic process, by transamination of glyoxylate, glyoxylate catabolic process, positive regulation of nitric oxide biosynthetic process; MF: (R)-3-amino-2-methylpropionate-pyruvate transaminase activity, alanine-glyoxylate transaminase activity, beta-alanine:pyruvate transaminase activity, pyridoxal phosphate binding, transaminase activity, transferase activity; CC: mitochondrion
Pathways: Alanine, aspartate and glutamate metabolism - Mus musculus (mouse), Cysteine and methionine metabolism - Mus musculus (mouse), Glycine, serine and threonine metabolism - Mus musculus (mouse), Glyoxylate metabolism and glycine degradation, Metabolism, Metabolism of amino acids and derivatives, Valine, leucine and isoleucine degradation - Mus musculus (mouse), glycine biosynthesis III
UniProt: Q3UEG6
Entrez ID: 268782
|
Does Knockout of Lingo2 in Embryonic Fibroblast Cell Line causally result in cell proliferation?
| 0
| 345
|
Knockout
|
Lingo2
|
cell proliferation
|
Embryonic Fibroblast Cell Line
|
Gene: Lingo2 (leucine rich repeat and Ig domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: positive regulation of synapse assembly, regulation of nervous system development; MF: molecular_function, signaling receptor activity; CC: glutamatergic synapse, membrane, plasma membrane, synaptic membrane
Pathways:
UniProt: Q3URE9
Entrez ID: 242384
|
Does Knockout of Uri1 in macrophage causally result in response to bacteria?
| 0
| 2,211
|
Knockout
|
Uri1
|
response to bacteria
|
macrophage
|
Gene: Uri1 (URI1, prefoldin-like chaperone)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cellular response to growth factor stimulus, cellular response to steroid hormone stimulus, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, negative regulation of intrinsic apoptotic signaling pathway, negative regulation of phosphatase activity, negative regulation of transcription by RNA polymerase II, regulation of cell growth, regulation of transcription by RNA polymerase II, response to virus; MF: RNA polymerase II complex binding, chromatin binding, phosphatase inhibitor activity, phosphoprotein binding, protein phosphatase inhibitor activity, transcription corepressor activity; CC: RPAP3/R2TP/prefoldin-like complex, cell projection, cytoplasm, cytosol, dendrite, mitochondrion, nucleoplasm, nucleus
Pathways:
UniProt: Q3TLD5
Entrez ID: 19777
|
Does Knockout of Mir338 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Mir338
|
cell cycle progression
|
breast epithelium
|
Gene: Mir338 (microRNA 338)
Type: ncRNA
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
Gene Ontology: BP: cellular response to growth factor stimulus, long-term synaptic potentiation, miRNA-mediated post-transcriptional gene silencing, myelination, negative regulation of gene expression, negative regulation of osteoblast differentiation, ossification, osteoblast differentiation, response to estrogen, response to wounding, sensory perception of sound; CC: RISC complex
Pathways:
UniProt:
Entrez ID: 723844
|
Does Knockout of Rcc1l in Embryonic Stem Cell Line causally result in cell proliferation?
| 1
| 579
|
Knockout
|
Rcc1l
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Rcc1l (reculator of chromosome condensation 1 like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: mitochondrial fusion, mitochondrial large ribosomal subunit assembly, mitochondrial small ribosomal subunit assembly; MF: guanyl-nucleotide exchange factor activity, protein binding, rRNA binding; CC: membrane, mitochondrial inner membrane, mitochondrial matrix, mitochondrial membrane, mitochondrion
Pathways:
UniProt: Q9CYF5
Entrez ID: 94254
|
Does Knockout of Pgm1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
Pgm1
|
response to virus
|
Microglial Cell Line
|
Gene: Pgm1 (phosphoglucomutase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, galactose catabolic process via UDP-galactose, Leloir pathway, glucose metabolic process, glycogen biosynthetic process, glycogen catabolic process; MF: intramolecular phosphotransferase activity, isomerase activity, magnesium ion binding, metal ion binding, phosphoglucomutase activity; CC: Z disc, cytoplasm, cytosol
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), GDP-glucose biosynthesis, Galactose catabolism, Galactose metabolism - Mus musculus (mouse), Glycogen breakdown (glycogenolysis), Glycogen metabolism, Glycogen synthesis, Glycolysis / Gluconeogenesis - Mus musculus (mouse), Immune System, Innate Immune System, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, Neutrophil degranulation, Pentose phosphate pathway - Mus musculus (mouse), Purine metabolism - Mus musculus (mouse), Starch and sucrose metabolism - Mus musculus (mouse), UDP-glucose conversion, glucose and glucose-1-phosphate degradation, glycogen degradation II, glycogen degradation III, starch degradation
UniProt: Q9D0F9
Entrez ID: 72157
|
Does Knockout of Cyp2d12 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,274
|
Knockout
|
Cyp2d12
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Cyp2d12 (cytochrome P450, family 2, subfamily d, polypeptide 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, xenobiotic metabolic process; MF: anandamide 11,12 epoxidase activity, anandamide 14,15 epoxidase activity, anandamide 8,9 epoxidase activity, aromatase activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, mitochondrion
Pathways: Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse)
UniProt: Q8BVD2, B7ZP10, A0A2R8VHA2, A0A2R8VJY6
Entrez ID: 380997
|
Does Knockout of Zfp746 in breast epithelium causally result in cell cycle progression?
| 0
| 1,468
|
Knockout
|
Zfp746
|
cell cycle progression
|
breast epithelium
|
Gene: Zfp746 (zinc finger protein 746)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of transcription by RNA polymerase II, protein heterooligomerization, protein homooligomerization, regulation of DNA-templated transcription; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, transcription cis-regulatory region binding, ubiquitin protein ligase binding, zinc ion binding; CC: cytoplasm, cytosol, nucleoplasm, nucleus
Pathways: Gene expression (Transcription), Generic Transcription Pathway, Herpes simplex virus 1 infection - Mus musculus (mouse), RNA Polymerase II Transcription
UniProt: Q3U133
Entrez ID: 69228
|
Does Knockout of Prkd2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Prkd2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Prkd2 (protein kinase D2)
Type: protein-coding
Summary: Predicted to enable protein kinase C binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in positive regulation of macromolecule biosynthetic process and positive regulation of signal transduction. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and vibrissa. Orthologous to human PRKD2 (protein kinase D2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: T cell receptor signaling pathway, adaptive immune response, angiogenesis, cell adhesion, cellular response to vascular endothelial growth factor stimulus, immune system process, intracellular signal transduction, phospholipase C-activating G protein-coupled receptor signaling pathway, positive regulation of DNA biosynthetic process, positive regulation of DNA-binding transcription factor activity, positive regulation of ERK1 and ERK2 cascade, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell receptor signaling pathway, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of cell adhesion, positive regulation of cell communication, positive regulation of endothelial cell chemotaxis, positive regulation of endothelial cell migration, positive regulation of endothelial cell proliferation, positive regulation of fibroblast growth factor receptor signaling pathway, positive regulation of interleukin-2 production, positive regulation of interleukin-8 production, positive regulation of signaling, positive regulation of transcription by RNA polymerase II, positive regulation of vascular endothelial growth factor receptor signaling pathway, regulation of T cell apoptotic process, vascular endothelial growth factor receptor signaling pathway; MF: ATP binding, diacylglycerol-dependent serine/threonine kinase activity, kinase activity, metal ion binding, nucleotide binding, protein kinase C binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity, zinc ion binding; CC: Golgi apparatus, cytoplasm, cytosol, membrane, nucleoplasm, nucleus, plasma membrane
Pathways: Aldosterone synthesis and secretion - Mus musculus (mouse), Chemical carcinogenesis - reactive oxygen species - Mus musculus (mouse), Rap1 signaling pathway - Mus musculus (mouse)
UniProt: Q8BZ03
Entrez ID: 101540
|
Does Knockout of Klf7 in macrophage causally result in phagocytosis?
| 0
| 1,889
|
Knockout
|
Klf7
|
phagocytosis
|
macrophage
|
Gene: Klf7 (Kruppel-like transcription factor 7 (ubiquitous))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon guidance, axonogenesis, dendrite morphogenesis, glucose homeostasis, negative regulation of adipose tissue development, negative regulation of insulin secretion involved in cellular response to glucose stimulus, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of epidermal cell differentiation, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, zinc ion binding; CC: cytosol, nucleoplasm, nucleus
Pathways:
UniProt: Q99JB0
Entrez ID: 93691
|
Does Knockout of Prrt2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,284
|
Knockout
|
Prrt2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Prrt2 (proline-rich transmembrane protein 2)
Type: protein-coding
Summary: Enables syntaxin-1 binding activity. Involved in negative regulation of short-term synaptic potentiation; regulation of vesicle fusion; and synaptic vesicle fusion to presynaptic active zone membrane. Located in axon terminus; plasma membrane; and synaptic vesicle. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in brain and spinal cord. Used to study episodic kinesigenic dyskinesia 1. Human ortholog(s) of this gene implicated in benign familial infantile seizures 2 and episodic kinesigenic dyskinesia 1. Orthologous to human PRRT2 (proline rich transmembrane protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: negative regulation of SNARE complex assembly, negative regulation of short-term synaptic potentiation, neuromuscular process controlling posture, regulation of calcium-dependent activation of synaptic vesicle fusion, synaptic vesicle fusion to presynaptic active zone membrane; MF: SH3 domain binding, protein binding, syntaxin-1 binding; CC: axon, axon terminus, cell projection, cytoplasmic vesicle, dendritic spine, glutamatergic synapse, membrane, neuron projection, plasma membrane, postsynaptic density membrane, postsynaptic membrane, presynapse, presynaptic membrane, synapse, synaptic vesicle, synaptic vesicle membrane, vesicle
Pathways:
UniProt: E9PUL5
Entrez ID: 69017
|
Does Knockout of Tmed5 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,269
|
Knockout
|
Tmed5
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Tmed5 (transmembrane p24 trafficking protein 5)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Golgi ribbon formation, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, protein transport; CC: COPII-coated ER to Golgi transport vesicle, Golgi apparatus, cis-Golgi network, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane
Pathways: Signal Transduction, Signaling by WNT, WNT ligand biogenesis and trafficking
UniProt: Q9CXE7
Entrez ID: 73130
|
Does Knockout of Ankrd7 in Microglial Cell Line causally result in protein/peptide accumulation?
| 0
| 1,399
|
Knockout
|
Ankrd7
|
protein/peptide accumulation
|
Microglial Cell Line
|
Gene: Ankrd7 (ankyrin repeat domain 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: centrosome, nucleoplasm, nucleus
Pathways:
UniProt: Q9D504
Entrez ID: 75196
|
Does Knockout of Fh1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,272
|
Knockout
|
Fh1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Fh1 (fumarate hydratase 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, arginine metabolic process, fumarate metabolic process, homeostasis of number of cells within a tissue, malate metabolic process, positive regulation of cold-induced thermogenesis, positive regulation of double-strand break repair via nonhomologous end joining, regulation of arginine metabolic process, tricarboxylic acid cycle, urea cycle; MF: catalytic activity, fumarate hydratase activity, histone binding, lyase activity; CC: chromosome, cytoplasm, cytosol, mitochondrial matrix, mitochondrion, nucleus, site of double-strand break
Pathways: Aerobic respiration and respiratory electron transport, Citrate cycle (TCA cycle) - Mus musculus (mouse), Citric acid cycle (TCA cycle), Cushing syndrome - Mus musculus (mouse), Metabolism, Metabolism of proteins, Mitochondrial protein degradation, Pathways in cancer - Mus musculus (mouse), Pyruvate metabolism - Mus musculus (mouse), Renal cell carcinoma - Mus musculus (mouse), TCA cycle, TCA cycle variation III (eukaryotic), glutamate degradation VII
UniProt: P97807
Entrez ID: 14194
|
Does Knockout of Lmcd1 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,281
|
Knockout
|
Lmcd1
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Lmcd1 (LIM and cysteine-rich domains 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, positive regulation of calcineurin-NFAT signaling cascade, regulation of cardiac muscle hypertrophy; MF: metal ion binding, protein binding, transcription corepressor activity, zinc ion binding; CC: cytoplasm, nucleus
Pathways: Metabolism of proteins, Surfactant metabolism
UniProt: Q8VEE1
Entrez ID: 30937
|
Does Knockout of Cyp2c37 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Cyp2c37
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Cyp2c37 (cytochrome P450, family 2. subfamily c, polypeptide 37)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arachidonate metabolic process, epoxygenase P450 pathway, lipid metabolic process, xenobiotic catabolic process; MF: arachidonate epoxygenase activity, arachidonate monooxygenase activity, caffeine oxidase activity, enzyme binding, estrogen 16-alpha-hydroxylase activity, heme binding, iron ion binding, long-chain fatty acid omega-1 hydroxylase activity, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, retinoic acid 4-hydroxylase activity, steroid hydroxylase activity; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum membrane, intracellular membrane-bounded organelle, membrane, plasma membrane
Pathways: Arachidonic acid metabolism - Mus musculus (mouse), Chemical carcinogenesis - DNA adducts - Mus musculus (mouse), Inflammatory mediator regulation of TRP channels - Mus musculus (mouse), Linoleic acid metabolism - Mus musculus (mouse), Retinol metabolism - Mus musculus (mouse), Serotonergic synapse - Mus musculus (mouse), Steroid hormone biosynthesis - Mus musculus (mouse), bupropion degradation, nicotine degradation II, nicotine degradation III
UniProt: P56654
Entrez ID: 13096
|
Does Knockout of Stx12 in Colonic Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,280
|
Knockout
|
Stx12
|
cell proliferation
|
Colonic Adenocarcinoma Cell Line
|
Gene: Stx12 (syntaxin 12)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: autophagosome assembly, cholesterol efflux, endocytic recycling, intracellular protein transport, organelle fusion, protein stabilization, protein transport, regulation of biological quality, regulation of postsynaptic membrane neurotransmitter receptor levels, synaptic vesicle to endosome fusion, vesicle docking, vesicle fusion, vesicle organization, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding, protein binding; CC: BLOC-1 complex, Golgi apparatus, Golgi membrane, SNARE complex, early endosome membrane, endomembrane system, endosome, endosome membrane, glutamatergic synapse, membrane, membrane raft, nucleoplasm, phagocytic vesicle, phagophore assembly site, postsynaptic recycling endosome, postsynaptic recycling endosome membrane, recycling endosome, recycling endosome membrane, synaptic vesicle, synaptic vesicle membrane, vesicle
Pathways: Phagosome - Mus musculus (mouse)
UniProt: Q9ER00
Entrez ID: 100226
|
Does Knockout of Zfp281 in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 161
|
Knockout
|
Zfp281
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Zfp281 (zinc finger protein 281)
Type: protein-coding
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic body morphogenesis and stem cell differentiation. Predicted to be located in nucleoplasm. Is expressed in several structures, including branchial arch; egg cylinder; genitourinary system; immune system; and intestine. Orthologous to human ZNF281 (zinc finger protein 281). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: cell differentiation, embryonic body morphogenesis, negative regulation of DNA-templated transcription, negative regulation of gene expression, negative regulation of transcription by RNA polymerase II, positive regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II, stem cell differentiation; MF: DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, protein binding, sequence-specific DNA binding, sequence-specific double-stranded DNA binding, transcription cis-regulatory region binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q99LI5
Entrez ID: 226442
|
Does Knockout of Retn in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Retn
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Retn (resistin)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: fat cell differentiation, negative regulation of feeding behavior, positive regulation of collagen metabolic process, positive regulation of progesterone secretion, positive regulation of smooth muscle cell migration, positive regulation of smooth muscle cell proliferation, positive regulation of synaptic transmission, response to insulin, signal transduction; CC: extracellular region, extracellular space
Pathways: Immune System, Innate Immune System, Neutrophil degranulation
UniProt: Q99P87
Entrez ID: 57264
|
Does Knockout of Atxn7 in Embryonic Cell Line causally result in protein/peptide accumulation?
| 0
| 1,152
|
Knockout
|
Atxn7
|
protein/peptide accumulation
|
Embryonic Cell Line
|
Gene: Atxn7 (ataxin 7)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: microtubule cytoskeleton organization, negative regulation of insulin-like growth factor receptor signaling pathway, negative regulation of microtubule depolymerization, positive regulation of DNA-templated transcription, positive regulation of transcription by RNA polymerase II, regulation of DNA repair, regulation of RNA splicing, regulation of transcription by RNA polymerase II; MF: chromatin binding, protein binding; CC: SAGA complex, cytoplasm, cytoskeleton, cytosol, microtubule cytoskeleton, nuclear matrix, nucleolus, nucleoplasm, nucleus, transcription factor TFTC complex
Pathways: Deubiquitination, Metabolism of proteins, Post-translational protein modification, Ub-specific processing proteases
UniProt: Q8R4I1
Entrez ID: 246103
|
Does Knockout of Phyhd1 in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,682
|
Knockout
|
Phyhd1
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Phyhd1 (phytanoyl-CoA dioxygenase domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: 2-oxoglutarate-dependent dioxygenase activity, dioxygenase activity, metal ion binding, oxidoreductase activity
Pathways:
UniProt: Q9DB26
Entrez ID: 227696
|
Does Knockout of Lonrf2 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,287
|
Knockout
|
Lonrf2
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Lonrf2 (LON peptidase N-terminal domain and ring finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: motor behavior, negative regulation of neuron apoptotic process, neuromuscular process, neuron apoptotic process, neuron projection development, protein quality control for misfolded or incompletely synthesized proteins, protein ubiquitination, response to sodium arsenite, spinal cord motor neuron differentiation; MF: metal ion binding, misfolded protein binding, protein binding, ribonucleoprotein complex binding, ubiquitin protein ligase activity, zinc ion binding; CC: cellular_component, cytoplasm
Pathways:
UniProt: F6ZE64, B2RT44
Entrez ID: 381338
|
Does Knockout of Dnajc2 in Breast Adenocarcinoma Cell Line causally result in tumorigenicity?
| 0
| 2,172
|
Knockout
|
Dnajc2
|
tumorigenicity
|
Breast Adenocarcinoma Cell Line
|
Gene: Dnajc2 (DnaJ heat shock protein family (Hsp40) member C2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: 'de novo' cotranslational protein folding, DNA replication, chromatin organization, negative regulation of DNA biosynthetic process, negative regulation of cell growth, positive regulation of DNA-templated transcription, regulation of translational fidelity; MF: Hsp70 protein binding, chromatin binding, histone binding, protein binding, ribosome binding, ubiquitin-modified histone reader activity; CC: cytoplasm, cytosol, nuclear membrane, nucleolus, nucleus
Pathways: Cellular response to heat stress, Cellular responses to stimuli, Cellular responses to stress, Regulation of HSF1-mediated heat shock response
UniProt: P54103
Entrez ID: 22791
|
Does Knockout of Pcsk1n in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Pcsk1n
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Pcsk1n (proprotein convertase subtilisin/kexin type 1 inhibitor)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: neuropeptide signaling pathway, peptide hormone processing, response to cold, response to dietary excess; MF: endopeptidase inhibitor activity, protein binding, serine-type endopeptidase inhibitor activity; CC: Golgi apparatus, extracellular region, extracellular space, secretory granule, trans-Golgi network
Pathways:
UniProt: Q9QXV0
Entrez ID: 30052
|
Does Knockout of Rtp2 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Rtp2
|
response to virus
|
Microglial Cell Line
|
Gene: Rtp2 (receptor transporter protein 2)
Type: protein-coding
Summary: Predicted to enable olfactory receptor binding activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste; protein insertion into membrane; and protein targeting to membrane. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be active in cell surface. Is expressed in olfactory epithelium. Orthologous to human RTP2 (receptor transporter protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: detection of chemical stimulus involved in sensory perception of bitter taste, protein insertion into membrane, protein targeting to membrane; MF: metal ion binding, olfactory receptor binding, zinc ion binding; CC: cell surface, endoplasmic reticulum membrane, membrane, plasma membrane
Pathways:
UniProt: Q80ZI2
Entrez ID: 224055
|
Does Knockout of Dkk4 in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,680
|
Knockout
|
Dkk4
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dkk4 (dickkopf WNT signaling pathway inhibitor 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of Wnt signaling pathway, negative regulation of canonical Wnt signaling pathway, negative regulation of hair follicle placode formation; MF: co-receptor binding, receptor antagonist activity; CC: extracellular region, extracellular space
Pathways: Alzheimer disease - Mus musculus (mouse), Negative regulation of TCF-dependent signaling by WNT ligand antagonists, Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Signal Transduction, Signaling by WNT, TCF dependent signaling in response to WNT, Wnt signaling pathway - Mus musculus (mouse)
UniProt: Q8VEJ3
Entrez ID: 234130
|
Does Knockout of Mpv17l in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,684
|
Knockout
|
Mpv17l
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Mpv17l (Mpv17 transgene, kidney disease mutant-like)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of hydrogen peroxide biosynthetic process, negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway, reactive oxygen species metabolic process; CC: cytoplasm, membrane, mitochondrion, peroxisomal membrane, peroxisome
Pathways: Peroxisome - Mus musculus (mouse)
UniProt: Q99MS3
Entrez ID: 93734
|
Does Knockout of Gab3 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,260
|
Knockout
|
Gab3
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Gab3 (growth factor receptor bound protein 2-associated protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: macrophage differentiation, signal transduction; MF: protein binding, signaling adaptor activity; CC: cellular_component, cytoplasm, cytosol
Pathways:
UniProt: Q8BSM5
Entrez ID: 210710
|
Does Knockout of Oosp3 in Embryonic Stem Cell Line causally result in cell proliferation?
| 0
| 579
|
Knockout
|
Oosp3
|
cell proliferation
|
Embryonic Stem Cell Line
|
Gene: Oosp3 (oocyte secreted protein 3)
Type: protein-coding
Summary: No summary available.
Gene Ontology:
Pathways:
UniProt: G5E8D7
Entrez ID: 225923
|
Does Knockout of Rfc2 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,484
|
Knockout
|
Rfc2
|
cell proliferation
|
Regulatory T cell
|
Gene: Rfc2 (replication factor C (activator 1) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA repair, DNA replication, DNA-templated DNA replication, positive regulation of DNA-directed DNA polymerase activity; MF: ATP binding, ATP hydrolysis activity, DNA binding, DNA clamp loader activity, enzyme binding, nucleotide binding, single-stranded DNA helicase activity; CC: Ctf18 RFC-like complex, DNA replication factor C complex, nucleus
Pathways: Activation of ATR in response to replication stress, Base Excision Repair, Cell Cycle, Cell Cycle Checkpoints, Cell Cycle, Mitotic, Chromosome Maintenance, DNA Damage Bypass, DNA Double-Strand Break Repair, DNA Repair, DNA Replication, DNA replication - Mus musculus (mouse), DNA strand elongation, Dual Incision in GG-NER, Dual incision in TC-NER, Extension of Telomeres, G2/M Checkpoints, G2/M DNA damage checkpoint, Gap-filling DNA repair synthesis and ligation in GG-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, Gene expression (Transcription), Generic Transcription Pathway, Global Genome Nucleotide Excision Repair (GG-NER), HDR through Homologous Recombination (HRR), HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA), HDR through Single Strand Annealing (SSA), Homology Directed Repair, Lagging Strand Synthesis, Leading Strand Synthesis, Mismatch repair - Mus musculus (mouse), Nucleotide Excision Repair, Nucleotide excision repair - Mus musculus (mouse), PCNA-Dependent Long Patch Base Excision Repair, Polymerase switching, Polymerase switching on the C-strand of the telomere, Processing of DNA double-strand break ends, RNA Polymerase II Transcription, Recognition of DNA damage by PCNA-containing replication complex, Regulation of TP53 Activity, Regulation of TP53 Activity through Phosphorylation, Resolution of AP sites via the multiple-nucleotide patch replacement pathway, Resolution of Abasic Sites (AP sites), S Phase, Synthesis of DNA, Telomere C-strand (Lagging Strand) Synthesis, Telomere Maintenance, Termination of translesion DNA synthesis, Transcription-Coupled Nucleotide Excision Repair (TC-NER), Transcriptional Regulation by TP53, Translesion Synthesis by POLH, Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q9WUK4
Entrez ID: 19718
|
Does Knockout of Traf2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,261
|
Knockout
|
Traf2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Traf2 (TNF receptor-associated factor 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD27 signaling pathway, CD40 signaling pathway, T cell activation, TORC1 complex assembly, TORC1 signaling, TORC2 complex disassembly, TORC2 signaling, apoptotic process, cellular response to nitric oxide, innate immune response, interleukin-17-mediated signaling pathway, mRNA stabilization, negative regulation of apoptotic process, negative regulation of canonical NF-kappaB signal transduction, negative regulation of glial cell apoptotic process, non-canonical NF-kappaB signal transduction, positive regulation of JUN kinase activity, positive regulation of NF-kappaB transcription factor activity, positive regulation of T cell cytokine production, positive regulation of canonical NF-kappaB signal transduction, positive regulation of extrinsic apoptotic signaling pathway, positive regulation of gene expression, positive regulation of interleukin-2 production, positive regulation of tumor necrosis factor-mediated signaling pathway, programmed cell death, programmed necrotic cell death, protein K63-linked ubiquitination, protein autoubiquitination, protein catabolic process, protein polyubiquitination, protein ubiquitination, protein-containing complex assembly, regulation of JNK cascade, regulation of MAPK cascade, regulation of apoptotic process, regulation of immunoglobulin production, regulation of production of molecular mediator of immune response, regulation of protein-containing complex assembly, signal transduction, signal transduction involved in regulation of gene expression, tumor necrosis factor-mediated signaling pathway; MF: CD40 receptor binding, enzyme binding, identical protein binding, lipid binding, metal ion binding, mitogen-activated protein kinase kinase kinase binding, protein binding, protein kinase binding, protein phosphatase binding, protein-containing complex binding, protein-macromolecule adaptor activity, signaling adaptor activity, sphingolipid binding, thioesterase binding, transferase activity, tumor necrosis factor binding, tumor necrosis factor receptor binding, tumor necrosis factor receptor superfamily binding, ubiquitin protein ligase activity, ubiquitin protein ligase binding, ubiquitin-protein transferase activity, zinc ion binding; CC: CD40 receptor complex, IRE1-TRAF2-ASK1 complex, TRAF2-GSTP1 complex, cell cortex, cytoplasm, cytoplasmic side of plasma membrane, cytosol, membrane raft, protein-containing complex, receptor complex, tumor necrosis factor receptor superfamily complex, ubiquitin ligase complex, vesicle membrane
Pathways: Adipocytokine signaling pathway - Mus musculus (mouse), Alzheimer disease - Mus musculus (mouse), Amyotrophic lateral sclerosis - Mus musculus (mouse), Apoptosis, Apoptosis - Mus musculus (mouse), CASP8 activity is inhibited, Caspase activation via Death Receptors in the presence of ligand, Caspase activation via extrinsic apoptotic signalling pathway, Cytokine Signaling in Immune system, Death Receptor Signaling, Deubiquitination, Dimerization of procaspase-8, Epstein-Barr virus infection - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Herpes simplex virus 1 infection - Mus musculus (mouse), Human cytomegalovirus infection - Mus musculus (mouse), Human immunodeficiency virus 1 infection - Mus musculus (mouse), Huntington disease - Mus musculus (mouse), IL-17 signaling pathway - Mus musculus (mouse), Immune System, Innate Immune System, Interleukin-1 family signaling, Interleukin-1 signaling, Kaposi sarcoma-associated herpesvirus infection - Mus musculus (mouse), Lipid and atherosclerosis - Mus musculus (mouse), MAPK signaling pathway - Mus musculus (mouse), Metabolism of proteins, MyD88 cascade initiated on plasma membrane, MyD88 dependent cascade initiated on endosome, MyD88-independent TLR4 cascade , MyD88:MAL(TIRAP) cascade initiated on plasma membrane, NF-kappa B signaling pathway - Mus musculus (mouse), NOD-like receptor signaling pathway - Mus musculus (mouse), Necroptosis - Mus musculus (mouse), Non-alcoholic fatty liver disease - Mus musculus (mouse), Osteoclast differentiation - Mus musculus (mouse), Pathways in cancer - Mus musculus (mouse), Pathways of neurodegeneration - multiple diseases - Mus musculus (mouse), Post-translational protein modification, Programmed Cell Death, Protein processing in endoplasmic reticulum - Mus musculus (mouse), RIG-I-like receptor signaling pathway - Mus musculus (mouse), RIPK1-mediated regulated necrosis, Regulated Necrosis, Regulation by c-FLIP, Regulation of NF-kappa B signaling, Regulation of TNFR1 signaling, Regulation of necroptotic cell death, Salmonella infection - Mus musculus (mouse), Signal Transduction, Signaling by Interleukins, Small cell lung cancer - Mus musculus (mouse), Sphingolipid signaling pathway - Mus musculus (mouse), Spinocerebellar ataxia - Mus musculus (mouse), TAK1-dependent IKK and NF-kappa-B activation , TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway, TNF signaling, TNF signaling pathway - Mus musculus (mouse), TNFR1-induced NF-kappa-B signaling pathway, TNFR1-induced proapoptotic signaling, TNFR2 non-canonical NF-kB pathway, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, TRIF (TICAM1)-mediated TLR4 signaling , Toll Like Receptor 10 (TLR10) Cascade, Toll Like Receptor 2 (TLR2) Cascade, Toll Like Receptor 3 (TLR3) Cascade, Toll Like Receptor 4 (TLR4) Cascade, Toll Like Receptor 5 (TLR5) Cascade, Toll Like Receptor 7/8 (TLR7/8) Cascade, Toll Like Receptor 9 (TLR9) Cascade, Toll Like Receptor TLR1:TLR2 Cascade, Toll Like Receptor TLR6:TLR2 Cascade, Toll-like Receptor Cascades, Ub-specific processing proteases, Viral carcinogenesis - Mus musculus (mouse), Yersinia infection - Mus musculus (mouse)
UniProt: P39429
Entrez ID: 22030
|
Does Knockout of Stkld1 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Stkld1
|
cell proliferation
|
Regulatory T cell
|
Gene: Stkld1 (serine/threonine kinase-like domain containing 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: ATP binding, nucleotide binding, protein kinase activity, protein serine/threonine kinase activity
Pathways:
UniProt: Q80YS9
Entrez ID: 279029
|
Does Knockout of Mettl13 in macrophage causally result in phagocytosis?
| 0
| 1,890
|
Knockout
|
Mettl13
|
phagocytosis
|
macrophage
|
Gene: Mettl13 (methyltransferase 13, eEF1A lysine and N-terminal methyltransferase)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: catalytic activity, methyltransferase activity, molecular_function, protein-lysine N-methyltransferase activity, transferase activity; CC: cytoplasm, cytosol, mitochondrion, nucleus
Pathways:
UniProt: Q91YR5
Entrez ID: 71449
|
Does Knockout of Ppfia1 in Regulatory T cell causally result in cell proliferation?
| 0
| 1,483
|
Knockout
|
Ppfia1
|
cell proliferation
|
Regulatory T cell
|
Gene: Ppfia1 (protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: cortical microtubule organization, negative regulation of protein localization to plasma membrane, negative regulation of stress fiber assembly, regulation of postsynaptic membrane neurotransmitter receptor levels, synapse organization; CC: Schaffer collateral - CA1 synapse, axon, cell cortex, cytoplasm, cytosol, dendrite, focal adhesion, presynaptic active zone, protein-containing complex, spine apparatus
Pathways: Acetylcholine Neurotransmitter Release Cycle, Dopamine Neurotransmitter Release Cycle, Glutamate Neurotransmitter Release Cycle, Neuronal System, Neurotransmitter release cycle, Norepinephrine Neurotransmitter Release Cycle, Protein-protein interactions at synapses, Receptor-type tyrosine-protein phosphatases, Serotonin Neurotransmitter Release Cycle, Transmission across Chemical Synapses
UniProt: B2RXW8, B2RXQ2, S4R1D4, S4R1I7
Entrez ID: 233977
|
Does Knockout of Mbl2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,838
|
Knockout
|
Mbl2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Mbl2 (mannose-binding lectin (protein C) 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: activation of membrane attack complex, antiviral innate immune response, cell surface pattern recognition receptor signaling pathway, complement activation, complement activation, classical pathway, complement activation, lectin pathway, defense response to Gram-positive bacterium, immune system process, innate immune response, killing by host of symbiont cells, killing of cells of another organism, leukocyte chemotaxis involved in immune response, negative regulation of viral process, opsonization, positive regulation of complement activation, positive regulation of opsonization, positive regulation of phagocytosis, positive regulation of protein processing, protein maturation, proteolysis, surfactant homeostasis, zymogen activation; MF: D-mannose binding, calcium ion binding, calcium-dependent protein binding, carbohydrate binding, galactose binding, identical protein binding, pattern recognition receptor activity, phosphatidylinositol-4-phosphate binding, protease binding, signaling receptor binding; CC: collagen trimer, extracellular region, extracellular space, multivesicular body, protein-containing complex, serine-type endopeptidase complex, symbiont cell surface
Pathways: Complement and coagulation cascades - Mus musculus (mouse), Complement cascade, Coronavirus disease - COVID-19 - Mus musculus (mouse), Creation of C4 and C2 activators, Immune System, Initial triggering of complement, Innate Immune System, Lectin pathway of complement activation, Phagosome - Mus musculus (mouse), Staphylococcus aureus infection - Mus musculus (mouse)
UniProt: P41317
Entrez ID: 17195
|
Does Knockout of Cldn1 in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 0
| 81
|
Knockout
|
Cldn1
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Cldn1 (claudin 1)
Type: protein-coding
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene die soon after birth as a consequence of dehydration from trandermal water loss, indicating that this gene is indispensable for creating and maintaining the epidermal barrier. The protein encoded by this gene also has gastric tumor suppressive activity, and is a key factor for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010].
Gene Ontology: BP: bicellular tight junction assembly, calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules, cell adhesion, cell junction maintenance, cell-cell junction organization, cellular response to butyrate, cellular response to lead ion, cellular response to transforming growth factor beta stimulus, cellular response to tumor necrosis factor, cellular response to type II interferon, establishment of blood-nerve barrier, establishment of endothelial intestinal barrier, establishment of skin barrier, liver regeneration, positive regulation of bicellular tight junction assembly, positive regulation of cell migration, positive regulation of epithelial cell proliferation involved in wound healing, positive regulation of wound healing, protein complex oligomerization, response to dexamethasone, response to ethanol, response to interleukin-18, response to lipopolysaccharide, response to toxic substance, symbiont entry into host cell, xenobiotic transport across blood-nerve barrier; MF: identical protein binding, protein binding, structural molecule activity, virus receptor activity; CC: anchoring junction, apical plasma membrane, basolateral plasma membrane, bicellular tight junction, cell junction, cell-cell junction, lateral plasma membrane, membrane, plasma membrane, protein-containing complex, tight junction
Pathways: Cell adhesion molecules - Mus musculus (mouse), Hepatitis C - Mus musculus (mouse), Leukocyte transendothelial migration - Mus musculus (mouse), Tight junction - Mus musculus (mouse)
UniProt: O88551
Entrez ID: 12737
|
Does Knockout of Ms4a8a in Pancreatic Cancer Cell Line causally result in response to chemicals?
| 0
| 2,359
|
Knockout
|
Ms4a8a
|
response to chemicals
|
Pancreatic Cancer Cell Line
|
Gene: Ms4a8a (membrane-spanning 4-domains, subfamily A, member 8A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: membrane, plasma membrane
Pathways:
UniProt: Q99N10
Entrez ID: 64381
|
Does Knockout of Rassf10 in breast epithelium causally result in cell cycle progression?
| 0
| 1,470
|
Knockout
|
Rassf10
|
cell cycle progression
|
breast epithelium
|
Gene: Rassf10 (Ras association (RalGDS/AF-6) domain family (N-terminal) member 10)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nervous system development, positive regulation of neural precursor cell proliferation, positive regulation of neurogenesis, signal transduction; CC: cellular_component, centrosome, cytoplasm, cytoskeleton, cytosol, spindle pole
Pathways:
UniProt: Q8BL43
Entrez ID: 78748
|
Does Knockout of Spata20 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 2,307
|
Knockout
|
Spata20
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Spata20 (spermatogenesis associated 20)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: carbohydrate metabolic process, cell differentiation, spermatogenesis
Pathways:
UniProt: Q80YT5
Entrez ID: 217116
|
Does Knockout of Prss45 in Mouse Embryonic Stem Cell causally result in protein/peptide accumulation?
| 0
| 1,077
|
Knockout
|
Prss45
|
protein/peptide accumulation
|
Mouse Embryonic Stem Cell
|
Gene: Prss45 (serine protease 45)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: proteolysis; MF: serine-type endopeptidase activity; CC: extracellular region, extracellular space
Pathways:
UniProt: Q8K4I7
Entrez ID: 260408
|
Does Knockout of Rev3l in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 81
|
Knockout
|
Rev3l
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Rev3l (REV3 like, DNA directed polymerase zeta catalytic subunit)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: DNA damage response, DNA repair, DNA replication, double-strand break repair via homologous recombination, error-prone translesion synthesis, translesion synthesis; MF: 4 iron, 4 sulfur cluster binding, DNA binding, DNA polymerase activity, DNA-directed DNA polymerase activity, iron-sulfur cluster binding, metal ion binding, nucleic acid binding, nucleotide binding, nucleotidyltransferase activity, transferase activity, zinc ion binding; CC: nuclear lumen, nucleolus, nucleus, zeta DNA polymerase complex
Pathways: DNA Damage Bypass, DNA Repair, Fanconi anemia pathway - Mus musculus (mouse), Translesion synthesis by POLI, Translesion synthesis by POLK, Translesion synthesis by REV1, Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
UniProt: Q61493
Entrez ID: 19714
|
Does Knockout of Cyb5r4 in Neuroblastoma Cell Line causally result in response to virus?
| 0
| 1,422
|
Knockout
|
Cyb5r4
|
response to virus
|
Neuroblastoma Cell Line
|
Gene: Cyb5r4 (cytochrome b5 reductase 4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: NADP+ metabolic process, cell development, glucose homeostasis, heme metabolic process, insulin secretion, reactive oxygen species metabolic process, response to antibiotic, superoxide metabolic process; MF: NAD(P)H oxidase H2O2-forming activity, NADPH-hemoprotein reductase activity, cytochrome-b5 reductase activity, acting on NAD(P)H, flavin adenine dinucleotide binding, heme binding, metal ion binding, oxidoreductase activity, oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor, protein binding; CC: cytoplasm, endoplasmic reticulum, perinuclear region of cytoplasm
Pathways: Amino sugar and nucleotide sugar metabolism - Mus musculus (mouse), Erythrocytes take up carbon dioxide and release oxygen, O2/CO2 exchange in erythrocytes, Transport of small molecules
UniProt: Q3TDX8
Entrez ID: 266690
|
Does Knockout of Dmpk in myoblast cell line causally result in protein/peptide distribution?
| 1
| 1,679
|
Knockout
|
Dmpk
|
protein/peptide distribution
|
myoblast cell line
|
Gene: Dmpk (dystrophia myotonica-protein kinase)
Type: protein-coding
Summary: The protein encoded by this gene is a serine/threonine protein kinase that contains coiled-coil and C-terminal membrane association domains. In the embryonic mouse, it is found in cardiac and skeletal myocytes where it appears to play a role in myogenesis. In adults, the transcript is localized to several tissues including brain, heart, and skeletal and smooth muscle, and a function in cytoskeletal remodeling has been described. Transcripts with expanded CUG repeats in the 3' untranslated region mediate alternative splicing of several genes and sequester RNA binding proteins and RNA transcripts that contain CAG repeats, resulting in myotonic dystrophy, an autosomal dominant neuromuscular disorder. Alternative splicing results in multiple protein coding and non-coding transcript variants. [provided by RefSeq, Oct 2014].
Gene Ontology: BP: establishment of localization in cell, intracellular calcium ion homeostasis, muscle cell apoptotic process, nuclear envelope organization, protein phosphorylation, regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction, regulation of heart contraction, regulation of myotube differentiation, regulation of skeletal muscle contraction by calcium ion signaling, regulation of sodium ion transport, regulation of synapse structural plasticity; MF: ATP binding, kinase activity, metal ion binding, myosin phosphatase regulator activity, nucleotide binding, protein binding, protein kinase activity, protein serine kinase activity, protein serine/threonine kinase activity, transferase activity; CC: cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, membrane, mitochondrial outer membrane, mitochondrion, nuclear membrane, nuclear outer membrane, nucleus, plasma membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane
Pathways: Cardiac conduction, Ion homeostasis, Muscle contraction
UniProt: P54265
Entrez ID: 13400
|
Does Knockout of Stx5a in Pre-B-Lymphocyte Cell Line causally result in cell proliferation?
| 1
| 82
|
Knockout
|
Stx5a
|
cell proliferation
|
Pre-B-Lymphocyte Cell Line
|
Gene: Stx5a (syntaxin 5A)
Type: protein-coding
Summary: Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in several processes, including Golgi disassembly; Golgi vesicle transport; and regulation of Golgi organization. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in Golgi apparatus and vesicle. Predicted to be part of SNARE complex. Predicted to be active in Golgi membrane. Is expressed in mesenchyme of metanephros and metanephros epithelium. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human STX5 (syntaxin 5). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: Golgi disassembly, early endosome to Golgi transport, endoplasmic reticulum to Golgi vesicle-mediated transport, intracellular protein transport, positive regulation of protein catabolic process, regulation of Golgi organization, retrograde transport, endosome to Golgi, retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum, vesicle docking, vesicle fusion, vesicle fusion with Golgi apparatus, vesicle-mediated transport; MF: SNAP receptor activity, SNARE binding; CC: Golgi apparatus, Golgi membrane, SNARE complex, cytosol, endomembrane system, endoplasmic reticulum-Golgi intermediate compartment membrane, membrane, vesicle
Pathways: Asparagine N-linked glycosylation, COPI-mediated anterograde transport, COPII-mediated vesicle transport, Cargo concentration in the ER, ER to Golgi Anterograde Transport, Insertion of tail-anchored proteins into the endoplasmic reticulum membrane, Intra-Golgi and retrograde Golgi-to-ER traffic, Intra-Golgi traffic, Membrane Trafficking, Metabolism of proteins, Post-translational protein modification, Protein localization, RHO GTPase cycle, RHOA GTPase cycle, RHOC GTPase cycle, RHOG GTPase cycle, SNARE interactions in vesicular transport - Mus musculus (mouse), Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3, Transport to the Golgi and subsequent modification, Vesicle-mediated transport
UniProt: Q8K1E0
Entrez ID: 56389
|
Does Knockout of Acaa1a in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,286
|
Knockout
|
Acaa1a
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Acaa1a (acetyl-Coenzyme A acyltransferase 1A)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: alpha-linolenic acid metabolic process, bile acid metabolic process, fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA oxidase, fatty acid derivative biosynthetic process, fatty acid metabolic process, lipid metabolic process, long-chain fatty acid biosynthetic process, phenylacetate catabolic process, response to nutrient, response to steroid hormone, unsaturated fatty acid biosynthetic process, very long-chain fatty acid metabolic process; MF: acetate CoA-transferase activity, acetyl-CoA C-acetyltransferase activity, acetyl-CoA C-acyltransferase activity, acetyl-CoA C-myristoyltransferase activity, acyltransferase activity, acyltransferase activity, transferring groups other than amino-acyl groups, transferase activity; CC: mitochondrion, peroxisomal matrix, peroxisome
Pathways: Biosynthesis of unsaturated fatty acids - Mus musculus (mouse), Fatty acid degradation - Mus musculus (mouse), PPAR signaling pathway - Mus musculus (mouse), Peroxisome - Mus musculus (mouse), Valine, leucine and isoleucine degradation - Mus musculus (mouse), alpha-Linolenic acid metabolism - Mus musculus (mouse), fatty acid β-oxidation I, fatty acid β-oxidation II (core pathway)
UniProt: Q921H8
Entrez ID: 113868
|
Does Knockout of Ccdc184 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 1,270
|
Knockout
|
Ccdc184
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Ccdc184 (coiled-coil domain containing 184)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: cytoplasm
Pathways:
UniProt: Q8BMK5
Entrez ID: 239650
|
Does Knockout of Vash2 in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,482
|
Knockout
|
Vash2
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Vash2 (vasohibin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: axon development, cell-cell fusion, labyrinthine layer blood vessel development, labyrinthine layer development, placenta blood vessel development, positive regulation of angiogenesis, positive regulation of endothelial cell proliferation, proteolysis, regulation of angiogenesis, syncytium formation by plasma membrane fusion; MF: actin binding, carboxypeptidase activity, hydrolase activity, metallocarboxypeptidase activity, microtubule binding, peptidase activity, protein binding, tubulin-tyrosine carboxypeptidase; CC: cytoplasm, cytoskeleton, cytosol, extracellular region
Pathways:
UniProt: Q8C5G2
Entrez ID: 226841
|
Does Knockout of Gtpbp2 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,663
|
Knockout
|
Gtpbp2
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Gtpbp2 (GTP binding protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: nuclear-transcribed mRNA catabolic process, no-go decay, rescue of stalled ribosome, translational elongation; MF: GTP binding, GTPase activity, alpha-aminoacyl-tRNA binding, identical protein binding, nucleotide binding, protein binding, translation elongation factor activity
Pathways: Hemostasis, Platelet activation, signaling and aggregation, Platelet degranulation , Response to elevated platelet cytosolic Ca2+
UniProt: Q3UJK4
Entrez ID: 56055
|
Does Knockout of Zfp2 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,488
|
Knockout
|
Zfp2
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Zfp2 (zinc finger protein 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II cis-regulatory region sequence-specific DNA binding, metal ion binding, zinc ion binding
Pathways: Gene expression (Transcription), Generic Transcription Pathway, RNA Polymerase II Transcription
UniProt: P08043
Entrez ID: 22678
|
Does Knockout of Zbtb2 in Mammary Gland Tumor Cell Line causally result in cell proliferation?
| 0
| 1,266
|
Knockout
|
Zbtb2
|
cell proliferation
|
Mammary Gland Tumor Cell Line
|
Gene: Zbtb2 (zinc finger and BTB domain containing 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: negative regulation of transcription by RNA polymerase II, regulation of cytokine production, regulation of immune system process; MF: DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA polymerase II cis-regulatory region sequence-specific DNA binding, identical protein binding, sequence-specific double-stranded DNA binding, zinc ion binding; CC: nucleoplasm, nucleus
Pathways:
UniProt: Q69ZI2, Q3V3W4, Q3V1Q5
Entrez ID: 381990
|
Does Knockout of Krt79 in Melanoma Cell Line causally result in cell proliferation?
| 0
| 2,492
|
Knockout
|
Krt79
|
cell proliferation
|
Melanoma Cell Line
|
Gene: Krt79 (keratin 79)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: intermediate filament organization, keratinization; MF: enzyme binding, structural constituent of skin epidermis; CC: intermediate filament, keratin filament
Pathways: Developmental Biology, Formation of the cornified envelope, Keratinization
UniProt: Q8VED5
Entrez ID: 223917
|
Does Knockout of H3f3a in myoblast cell line causally result in protein/peptide distribution?
| 0
| 1,681
|
Knockout
|
H3f3a
|
protein/peptide distribution
|
myoblast cell line
|
Gene: H3f3a (H3.3 histone A)
Type: protein-coding
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Nov 2015].
Gene Ontology:
Pathways: Adaptive Immune System, Adherens junctions interactions, Alcoholism - Mus musculus (mouse), Cell Cycle, Cell Cycle, Mitotic, Cell junction organization, Cell-Cell communication, Cell-cell junction organization, Chromosome Maintenance, Co-inhibition by PD-1, Condensation of Prophase Chromosomes, ESR-mediated signaling, Epigenetic regulation by WDR5-containing histone modifying complexes, Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes, Epigenetic regulation of gene expression, Epigenetic regulation of gene expression by MLL3 and MLL4 complexes, Estrogen-dependent gene expression, Factors involved in megakaryocyte development and platelet production, Gene expression (Transcription), Generic Transcription Pathway, Hemostasis, Immune System, Inhibition of DNA recombination at telomere, M Phase, MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis, Mitotic Prophase, Negative Regulation of CDH1 Gene Transcription, Neutrophil extracellular trap formation - Mus musculus (mouse), PRC2 methylates histones and DNA, RNA Polymerase II Transcription, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function, Regulation of CDH1 Expression and Function, Regulation of CDH1 Gene Transcription, Regulation of Expression and Function of Type I Classical Cadherins, Regulation of Homotypic Cell-Cell Adhesion, Regulation of PD-L1(CD274) expression, Regulation of PD-L1(CD274) transcription, Regulation of T cell activation by CD28 family, Regulation of endogenous retroelements, Regulation of endogenous retroelements by KRAB-ZFP proteins, Signal Transduction, Signaling by Nuclear Receptors, Systemic lupus erythematosus - Mus musculus (mouse), Telomere Maintenance, Transcriptional misregulation in cancer - Mus musculus (mouse), Transcriptional regulation by RUNX1
UniProt: P84244
Entrez ID: 15078
|
Does Knockout of Tmem216 in Microglial Cell Line causally result in phagocytosis?
| 0
| 1,587
|
Knockout
|
Tmem216
|
phagocytosis
|
Microglial Cell Line
|
Gene: Tmem216 (transmembrane protein 216)
Type: protein-coding
Summary: This gene encodes a transmembrane protein which is involved in regulation of signaling and trafficking of associated proteins. In humans, mutations in this gene are associated with ciliopathies including Joubert, Meckel and related syndromes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2013].
Gene Ontology: BP: cell projection organization, cilium assembly, non-motile cilium assembly; CC: MKS complex, cell projection, ciliary transition zone, cilium, cytoplasm, cytoskeleton, membrane
Pathways: Anchoring of the basal body to the plasma membrane, Cilium Assembly, Organelle biogenesis and maintenance
UniProt: Q9CQC4
Entrez ID: 68642
|
Does Knockout of Urgcp in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Urgcp
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Urgcp (upregulator of cell proliferation)
Type: protein-coding
Summary: No summary available.
Gene Ontology: MF: GTP binding, molecular_function, nucleotide binding; CC: cytoplasm, cytosol, nucleus
Pathways:
UniProt: Q5NCI0
Entrez ID: 72046
|
Does Knockout of Ccr9 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Ccr9
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Ccr9 (C-C motif chemokine receptor 9)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: CD8-positive, gamma-delta intraepithelial T cell differentiation, G protein-coupled receptor signaling pathway, calcium-mediated signaling, cell chemotaxis, chemokine-mediated signaling pathway, chemotaxis, immune response, positive regulation of cytosolic calcium ion concentration, signal transduction; MF: C-C chemokine binding, C-C chemokine receptor activity, G protein-coupled receptor activity, chemokine receptor activity, protein binding; CC: cell surface, external side of plasma membrane, membrane, plasma membrane
Pathways: Chemokine receptors bind chemokines, Chemokine signaling pathway - Mus musculus (mouse), Class A/1 (Rhodopsin-like receptors), Cytokine-cytokine receptor interaction - Mus musculus (mouse), G alpha (i) signalling events, GPCR downstream signalling, GPCR ligand binding, Intestinal immune network for IgA production - Mus musculus (mouse), Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR, Viral protein interaction with cytokine and cytokine receptor - Mus musculus (mouse)
UniProt: Q9WUT7
Entrez ID: 12769
|
Does Knockout of Slc35e4 in Immortal Mouse Liver-derived Cell Line causally result in tumorigenicity?
| 0
| 687
|
Knockout
|
Slc35e4
|
tumorigenicity
|
Immortal Mouse Liver-derived Cell Line
|
Gene: Slc35e4 (solute carrier family 35, member E4)
Type: protein-coding
Summary: No summary available.
Gene Ontology: CC: Golgi apparatus, membrane
Pathways:
UniProt: Q8K3D6
Entrez ID: 103710
|
Does Knockout of Prok2 in Embryonic Fibroblast Cell Line causally result in response to virus?
| 0
| 1,133
|
Knockout
|
Prok2
|
response to virus
|
Embryonic Fibroblast Cell Line
|
Gene: Prok2 (prokineticin 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: angiogenesis, chemotaxis, circadian rhythm, coronary vasculature development, endothelial cell proliferation, epicardium-derived cardiac endothelial cell differentiation, epicardium-derived cardiac vascular smooth muscle cell differentiation, negative regulation of apoptotic process, neuropeptide signaling pathway, positive regulation of smooth muscle contraction, rhythmic process, spermatogenesis, vasculogenesis involved in coronary vascular morphogenesis; MF: G protein-coupled receptor binding
Pathways: Class A/1 (Rhodopsin-like receptors), G alpha (q) signalling events, GPCR downstream signalling, GPCR ligand binding, Peptide ligand-binding receptors, Signal Transduction, Signaling by GPCR
UniProt: Q9QXU7
Entrez ID: 50501
|
Does Knockout of Csgalnact1 in Mouse kidney carcinoma cell causally result in cell proliferation?
| 0
| 1,259
|
Knockout
|
Csgalnact1
|
cell proliferation
|
Mouse kidney carcinoma cell
|
Gene: Csgalnact1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1)
Type: protein-coding
Summary: Enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate proteoglycan biosynthetic process. Acts upstream of or within chondroitin sulfate proteoglycan metabolic process; extracellular matrix organization; and skeletal system development. Is active in Golgi apparatus. Is expressed in several structures, including alimentary system; cartilage; limb; nervous system; and sensory organ. Orthologous to human CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Gene Ontology: BP: UDP-N-acetylgalactosamine metabolic process, UDP-glucuronate metabolic process, cartilage development, chondroitin sulfate proteoglycan biosynthetic process, chondroitin sulfate proteoglycan metabolic process, endochondral ossification, extracellular matrix organization; MF: acetylgalactosaminyltransferase activity, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, glucuronosyltransferase activity, glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity, metal ion binding, peptidoglycan glycosyltransferase activity, transferase activity; CC: Golgi apparatus, Golgi cisterna membrane, membrane
Pathways: CS-GAG biosynthesis, Chondroitin sulfate/dermatan sulfate metabolism, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Mus musculus (mouse), Glycosaminoglycan metabolism, Metabolism, Metabolism of carbohydrates and carbohydrate derivatives, chondroitin and dermatan biosynthesis, chondroitin sulfate biosynthesis, dermatan sulfate biosynthesis
UniProt: Q8BJQ9
Entrez ID: 234356
|
Does Knockout of Zbed6 in Regulatory T cell causally result in cell proliferation?
| 0
| 2,127
|
Knockout
|
Zbed6
|
cell proliferation
|
Regulatory T cell
|
Gene: Zbed6 (zinc finger, BED type containing 6)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: blastocyst hatching, negative regulation of DNA-templated transcription, negative regulation of muscle cell differentiation, negative regulation of transcription by RNA polymerase II, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription repressor activity, RNA polymerase II-specific, metal ion binding, protein dimerization activity, transcription cis-regulatory region binding, zinc ion binding; CC: centriolar satellite, cytoplasm, nucleolus, nucleoplasm, nucleus
Pathways:
UniProt: D2EAC2
Entrez ID: 667118
|
Does Knockout of Tfb2m in Embryonic Fibroblast Cell Line causally result in regulation of signal transduction phenotype?
| 0
| 167
|
Knockout
|
Tfb2m
|
regulation of signal transduction phenotype
|
Embryonic Fibroblast Cell Line
|
Gene: Tfb2m (transcription factor B2, mitochondrial)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: methylation, mitochondrial transcription, rRNA methylation, rRNA modification, rRNA processing, transcription initiation at mitochondrial promoter; MF: RNA binding, methyltransferase activity, mitochondrial transcription factor activity, rRNA (adenine-N6,N6-)-dimethyltransferase activity, rRNA (adenine-N6-)-methyltransferase activity, transferase activity; CC: mitochondrial matrix, mitochondrial nucleoid, mitochondrion
Pathways: Gene expression (Transcription), Mitochondrial transcription initiation, Transcription from mitochondrial promoters
UniProt: Q3TL26
Entrez ID: 15278
|
Does Knockout of Lonrf2 in Pancreatic Ductal Adenocarcinoma Cell Line causally result in response to chemicals?
| 0
| 1,565
|
Knockout
|
Lonrf2
|
response to chemicals
|
Pancreatic Ductal Adenocarcinoma Cell Line
|
Gene: Lonrf2 (LON peptidase N-terminal domain and ring finger 2)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: motor behavior, negative regulation of neuron apoptotic process, neuromuscular process, neuron apoptotic process, neuron projection development, protein quality control for misfolded or incompletely synthesized proteins, protein ubiquitination, response to sodium arsenite, spinal cord motor neuron differentiation; MF: metal ion binding, misfolded protein binding, protein binding, ribonucleoprotein complex binding, ubiquitin protein ligase activity, zinc ion binding; CC: cellular_component, cytoplasm
Pathways:
UniProt: F6ZE64, B2RT44
Entrez ID: 381338
|
Does Knockout of Stard8 in Breast Adenocarcinoma Cell Line causally result in cell proliferation?
| 0
| 1,277
|
Knockout
|
Stard8
|
cell proliferation
|
Breast Adenocarcinoma Cell Line
|
Gene: Stard8 (StAR related lipid transfer domain containing 8)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: actin cytoskeleton organization, regulation of Rho protein signal transduction, signal transduction; MF: GTPase activator activity, lipid binding; CC: anchoring junction, focal adhesion
Pathways: CDC42 GTPase cycle, RHO GTPase cycle, RHOA GTPase cycle, RHOB GTPase cycle, Signal Transduction, Signaling by Rho GTPases, Signaling by Rho GTPases, Miro GTPases and RHOBTB3
UniProt: Q8K031
Entrez ID: 236920
|
Does Knockout of N6amt1 in Microglial Cell Line causally result in response to virus?
| 0
| 2,429
|
Knockout
|
N6amt1
|
response to virus
|
Microglial Cell Line
|
Gene: N6amt1 (N-6 adenine-specific DNA methyltransferase 1 (putative))
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: arsonoacetate metabolic process, chromatin organization, methylation, negative regulation of gene expression, epigenetic, peptidyl-glutamine methylation, positive regulation of cell growth, toxin metabolic process, transcription initiation-coupled chromatin remodeling; MF: S-adenosyl-L-methionine binding, S-adenosylmethionine-dependent methyltransferase activity, arsenite methyltransferase activity, histone H4K12 methyltransferase activity, histone methyltransferase activity, methyltransferase activity, nucleic acid binding, protein binding, protein methyltransferase activity, protein-glutamine N-methyltransferase activity, site-specific DNA-methyltransferase (adenine-specific) activity, transferase activity; CC: eRF1 methyltransferase complex, nucleus, protein-containing complex
Pathways: Biological oxidations, Eukaryotic Translation Termination, Metabolism, Metabolism of proteins, Methylation, Phase II - Conjugation of compounds, Translation
UniProt: Q6SKR2
Entrez ID: 67768
|
Does Knockout of Hbp1 in Microglial Cell Line causally result in response to virus?
| 0
| 1,439
|
Knockout
|
Hbp1
|
response to virus
|
Microglial Cell Line
|
Gene: Hbp1 (high mobility group box transcription factor 1)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: Wnt signaling pathway, negative regulation of lipid transport, negative regulation of macrophage derived foam cell differentiation, negative regulation of reactive oxygen species biosynthetic process, negative regulation of transcription by RNA polymerase II, positive regulation of potassium ion transport, regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II; MF: DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, RNA binding, RNA polymerase II cis-regulatory region sequence-specific DNA binding, protein binding; CC: nuclear speck, nucleoplasm, nucleus
Pathways:
UniProt: Q8R316
Entrez ID: 73389
|
Does Knockout of Ppib in Regulatory T cell causally result in protein/peptide accumulation?
| 0
| 1,481
|
Knockout
|
Ppib
|
protein/peptide accumulation
|
Regulatory T cell
|
Gene: Ppib (peptidylprolyl isomerase B)
Type: protein-coding
Summary: No summary available.
Gene Ontology: BP: bone development, host-mediated activation of viral genome replication, host-mediated activation of viral process, neutrophil chemotaxis, positive regulation of multicellular organism growth, protein folding, protein stabilization; MF: RNA polymerase binding, collagen binding, cyclosporin A binding, isomerase activity, peptidyl-prolyl cis-trans isomerase activity, protein binding; CC: cytoplasm, endoplasmic reticulum, endoplasmic reticulum chaperone complex, endoplasmic reticulum lumen, intracellular membrane-bounded organelle, melanosome, nucleoplasm, perinuclear region of cytoplasm, protein-containing complex, smooth endoplasmic reticulum
Pathways:
UniProt: P24369
Entrez ID: 19035
|
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