uuid stringlengths 4 8 | template_uuid stringclasses 40 values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 138 627 | execution_results stringlengths 2 1.14M | query_type stringclasses 2 values | sql_category stringclasses 26 values | bio_category stringclasses 14 values |
|---|---|---|---|---|---|---|---|---|
Q10.665 | Q10 | Are there any MIR5685 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within MIR5685 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MIR5685' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1626 | Q10 | Are there any RBM15 SNPs that have a statistically significant association with Alzheimer's Disease? | No, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are no SNPs within RBM15 that are significantly associated with Alzheimer's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RBM15' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1028 | Q10 | Are there any CTD-2651B20.4 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within CTD-2651B20.4 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTD-2651B20.4' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1994 | Q10 | Are there any MRPL23-AS1 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within MRPL23-AS1 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MRPL23-AS1' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1519 | Q10 | Are there any AKR7A3 SNPs that have a statistically significant association with Progressive supranuclear palsy? | No, according to genome-wide analysis of Progressive supranuclear palsy (Höglinger et al., 2011), there are no SNPs within AKR7A3 that are significantly associated with Progressive supranuclear palsy. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AKR7A3' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.968 | Q10 | Are there any UGCG SNPs that have a statistically significant association with Amyotrophic Lateral Sclerosis? | No, according to genome-wide analysis of Amyotrophic Lateral Sclerosis (Nicolas et al., 2018), there are no SNPs within UGCG that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'UGCG' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.1883 | Q10 | Are there any TRAPPC6A SNPs that have a statistically significant association with Alzheimer's Disease? | Yes, according to the largest European genome-wide meta-analysis of Alzheimer's Disease (Bellenguez, 2022), there are at least 3 TRAPPC6A SNPs that are significantly associatied with Alzheimer's Disease:
• rs12462040 (GWAS p-value: 3.96e-26; b-value: -0.1512)
• rs75858218 (GWAS p-value: 1.14e-17; b-value: 0.1378)
• rs10408847 (GWAS p-value: 3.95e-11; b-value: 0.0687) | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRAPPC6A' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1108036', 'Gene': 'TRAPPC6A', 'topRSID': 'rs12462040', 'p_GWAS': 3.957646e-26, 'b_GWAS': -0.1512}, {'UUID': 'NDD_SMR_genes_all_update_text_1397653', 'Gene': 'TRAPPC6A', 'topRSID': 'rs75858218', 'p_GWAS': 1.1384460000000001e-17, 'b_GWAS': 0.1378}, {'UUID': 'NDD_SMR_genes_all_update_text_1503914', 'Gene': 'TRAPPC6A', 'topRSID': 'rs10408847', 'p_GWAS': 3.954585e-11, 'b_GWAS': 0.0687}] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q10.287 | Q10 | Are there any LILRA3 SNPs that have a statistically significant association with Parkinson's Disease? | No, according to the largest European genome-wide meta-analysis of Parkinson's Disease (Nalls et al., 2019), there are no SNPs within LILRA3 that are significantly associated with Parkinson's Disease. | SELECT DISTINCT UUID, Gene, topRSID, p_GWAS, b_GWAS
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LILRA3' AND p_GWAS < 5e-8
ORDER BY p_GWAS
LIMIT 100 | [] | refined | Distinct, Multi-Filter, Order By | GWAS Significance |
Q11.589 | Q11 | Are there any CTC-260E6.6 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CTC-260E6.6 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CTC-260E6.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1868 | Q11 | Are there any RP11-693J15.4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-693J15.4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-693J15.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1061 | Q11 | Are there any TAS2R60 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TAS2R60 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs11769559
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.80e-10; HEIDI: 1.1049e-01
• rs11771145
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.52e-09; HEIDI: 2.3818e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TAS2R60' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1649765', 'Gene': 'TAS2R60', 'topRSID': 'rs11769559', 'p_SMR_multi': 1.80317e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1104902}, {'UUID': 'NDD_SMR_genes_all_update_text_1496072', 'Gene': 'TAS2R60', 'topRSID': 'rs11771145', 'p_SMR_multi': 1.519833e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2381783}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1084 | Q11 | Are there any CLASRP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CLASRP gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1560725
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.09e-14; HEIDI: 7.7273e-12
• rs10416445
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.37e-08; HEIDI: 7.9839e-12
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CLASRP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_637443', 'Gene': 'CLASRP', 'topRSID': 'rs1560725', 'p_SMR_multi': 2.085517e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.727262e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_637444', 'Gene': 'CLASRP', 'topRSID': 'rs10416445', 'p_SMR_multi': 9.366781e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.983891e-12}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.925 | Q11 | Are there any PIN1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene PIN1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PIN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.73 | Q11 | Are there any RBM16 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RBM16 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RBM16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.435 | Q11 | Are there any RP11-475O6.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene RP11-475O6.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-475O6.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.911 | Q11 | Are there any SNX31 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the SNX31 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1693551
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.09e-07; HEIDI: 6.0315e-01
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 2.01e-07; HEIDI: 5.9220e-01
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.91e-07; HEIDI: 8.8502e-01
• rs1693560
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.21e-07; HEIDI: 7.3481e-01
• rs1693568
• Cerebellum: Adjusted SMR multi-SNP P-value: 4.69e-07; HEIDI: 7.1607e-01
• Cortex: Adjusted SMR multi-SNP P-value: 1.78e-06; HEIDI: 5.8104e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SNX31' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1288287', 'Gene': 'SNX31', 'topRSID': 'rs1693551', 'p_SMR_multi': 1.089976e-07, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.6031476}, {'UUID': 'NDD_SMR_genes_all_update_text_1340611', 'Gene': 'SNX31', 'topRSID': 'rs1693551', 'p_SMR_multi': 2.012102e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.5921966}, {'UUID': 'NDD_SMR_genes_all_update_text_1608145', 'Gene': 'SNX31', 'topRSID': 'rs1693560', 'p_SMR_multi': 3.210118e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.7348103}, {'UUID': 'NDD_SMR_genes_all_update_text_3737', 'Gene': 'SNX31', 'topRSID': 'rs1693568', 'p_SMR_multi': 4.685159e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.7160667}, {'UUID': 'NDD_SMR_genes_all_update_text_1688163', 'Gene': 'SNX31', 'topRSID': 'rs1693551', 'p_SMR_multi': 8.906882e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.8850191}, {'UUID': 'NDD_SMR_genes_all_update_text_1109774', 'Gene': 'SNX31', 'topRSID': 'rs1693568', 'p_SMR_multi': 1.780954e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.5810352}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.922 | Q11 | Are there any RP11-574K11.28 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-574K11.28 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-574K11.28' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1679 | Q11 | Are there any ABCF3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Blood, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ABCF3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ABCF3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1272 | Q11 | Are there any IGLV4-69 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene IGLV4-69 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'IGLV4-69' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1094 | Q11 | Are there any C7orf50 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene C7orf50 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'C7orf50' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.389 | Q11 | Are there any MARCH10 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested there are no SNPs within the gene MARCH10 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MARCH10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.841 | Q11 | Are there any SSPN SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene SSPN that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SSPN' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.774 | Q11 | Are there any GRHPR SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene GRHPR that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GRHPR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1805 | Q11 | Are there any HCP5 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the HCP5 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs139063538
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.04e-07; HEIDI: 1.4936e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'HCP5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620885', 'Gene': 'HCP5', 'topRSID': 'rs139063538', 'p_SMR_multi': 5.036251e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001493575}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1992 | Q11 | Are there any DYDC1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the DYDC1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs10749575
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.56e-07; HEIDI: 2.3054e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'DYDC1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_572625', 'Gene': 'DYDC1', 'topRSID': 'rs10749575', 'p_SMR_multi': 8.563031e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02305442}, {'UUID': 'NDD_SMR_genes_all_update_text_572626', 'Gene': 'DYDC1', 'topRSID': 'rs10749575', 'p_SMR_multi': 1.130184e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.003280651}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1066 | Q11 | Are there any LST1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene LST1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LST1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.58 | Q11 | Are there any FTLP17 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene FTLP17 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'FTLP17' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1688 | Q11 | Are there any RNF216-IT1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RNF216-IT1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RNF216-IT1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1955 | Q11 | Are there any PEA15 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene PEA15 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PEA15' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1218 | Q11 | Are there any HCG4P3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene HCG4P3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'HCG4P3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1680 | Q11 | Are there any GTPBP10 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene GTPBP10 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'GTPBP10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1975 | Q11 | Are there any RP11-476D10.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RP11-476D10.1 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs2638222
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.85e-07; HEIDI: 2.7878e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-476D10.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1561428', 'Gene': 'RP11-476D10.1', 'topRSID': 'rs2638222', 'p_SMR_multi': 7.845953e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0002787799}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.213 | Q11 | Are there any PPP3R2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene PPP3R2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PPP3R2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1534 | Q11 | Are there any CCDC91 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CCDC91 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CCDC91' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1135 | Q11 | Are there any SCARNA5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene SCARNA5 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SCARNA5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.131 | Q11 | Are there any GCKR SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene GCKR that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GCKR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.819 | Q11 | Are there any RP11-80H8.4 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene RP11-80H8.4 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-80H8.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1282 | Q11 | Are there any FLNB SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene FLNB that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FLNB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1872 | Q11 | Are there any CRISPLD2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CRISPLD2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CRISPLD2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.438 | Q11 | Are there any KANSL1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the KANSL1 gene has 9 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2696569
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.27e-08; HEIDI: 1.2584e-02
• rs199447
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 7.67e-08; HEIDI: 2.5230e-04
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 8.81e-07; HEIDI: 8.7602e-01
• rs12150087
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.65e-07; HEIDI: 1.8468e-03
• rs62073098
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.67e-07; HEIDI: -9.9990e+03
• rs199457
• Cortex: Adjusted SMR multi-SNP P-value: 7.58e-07; HEIDI: 9.1736e-01
• rs10514904
• Whole Brain: Adjusted SMR multi-SNP P-value: 7.69e-07; HEIDI: 2.9967e-02
• rs55987700
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.42e-06; HEIDI: 3.2562e-01
• rs2532233
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.65e-06; HEIDI: 9.6884e-02
• rs12951057
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.40e-06; HEIDI: 2.0442e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'KANSL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_115207', 'Gene': 'KANSL1', 'topRSID': 'rs2696569', 'p_SMR_multi': 5.266316e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01258408}, {'UUID': 'NDD_SMR_genes_all_update_text_1203011', 'Gene': 'KANSL1', 'topRSID': 'rs199447', 'p_SMR_multi': 7.667099e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.0002523026}, {'UUID': 'NDD_SMR_genes_all_update_text_115208', 'Gene': 'KANSL1', 'topRSID': 'rs2696569', 'p_SMR_multi': 1.339626e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0009945204}, {'UUID': 'NDD_SMR_genes_all_update_text_115204', 'Gene': 'KANSL1', 'topRSID': 'rs12150087', 'p_SMR_multi': 1.653432e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.001846827}, {'UUID': 'NDD_SMR_genes_all_update_text_115217', 'Gene': 'KANSL1', 'topRSID': 'rs62073098', 'p_SMR_multi': 3.667803e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_115205', 'Gene': 'KANSL1', 'topRSID': 'rs12150087', 'p_SMR_multi': 4.430445e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1106830', 'Gene': 'KANSL1', 'topRSID': 'rs199457', 'p_SMR_multi': 7.577246e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.9173582}, {'UUID': 'NDD_SMR_genes_all_update_text_115203', 'Gene': 'KANSL1', 'topRSID': 'rs10514904', 'p_SMR_multi': 7.687888e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.02996729}, {'UUID': 'NDD_SMR_genes_all_update_text_1396749', 'Gene': 'KANSL1', 'topRSID': 'rs199447', 'p_SMR_multi': 8.813429e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.8760188}, {'UUID': 'NDD_SMR_genes_all_update_text_115201', 'Gene': 'KANSL1', 'topRSID': 'rs55987700', 'p_SMR_multi': 1.422011e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.3256178}, {'UUID': 'NDD_SMR_genes_all_update_text_591218', 'Gene': 'KANSL1', 'topRSID': 'rs2532233', 'p_SMR_multi': 1.651529e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0968839}, {'UUID': 'NDD_SMR_genes_all_update_text_1502448', 'Gene': 'KANSL1', 'topRSID': 'rs12951057', 'p_SMR_multi': 2.401427e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.044173e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.417 | Q11 | Are there any OR9Q2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene OR9Q2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'OR9Q2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1504 | Q11 | Are there any CSNK1G2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CSNK1G2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CSNK1G2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.234 | Q11 | Are there any HOXD-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene HOXD-AS1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'HOXD-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1708 | Q11 | Are there any C6orf10 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the C6orf10 gene has 7 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs35265698
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.93e-08; HEIDI: 2.3441e-06
• rs116667074
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.45e-08; HEIDI: 3.9442e-02
• rs9271543
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.52e-08; HEIDI: 1.2118e-01
• rs6937318
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.32e-07; HEIDI: 5.9927e-03
• rs679242
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.69e-07; HEIDI: 7.5084e-07
• rs601945
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.19e-07; HEIDI: 5.3810e-06
• rs2076538
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.83e-06; HEIDI: 1.7969e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C6orf10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_621662', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_SMR_multi': 2.929935e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.344082e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_621660', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_SMR_multi': 3.712767e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.430729e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_621661', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_SMR_multi': 5.706762e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.469903e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_621669', 'Gene': 'C6orf10', 'topRSID': 'rs116667074', 'p_SMR_multi': 6.447594e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03944189}, {'UUID': 'NDD_SMR_genes_all_update_text_621667', 'Gene': 'C6orf10', 'topRSID': 'rs9271543', 'p_SMR_multi': 8.523301e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.121175}, {'UUID': 'NDD_SMR_genes_all_update_text_621648', 'Gene': 'C6orf10', 'topRSID': 'rs116667074', 'p_SMR_multi': 1.103085e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03721245}, {'UUID': 'NDD_SMR_genes_all_update_text_621653', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_SMR_multi': 1.820986e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.50754e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_621651', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_SMR_multi': 2.723386e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.749152e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_621665', 'Gene': 'C6orf10', 'topRSID': 'rs6937318', 'p_SMR_multi': 5.316686e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.005992745}, {'UUID': 'NDD_SMR_genes_all_update_text_621652', 'Gene': 'C6orf10', 'topRSID': 'rs679242', 'p_SMR_multi': 5.688821e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.508439e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_621657', 'Gene': 'C6orf10', 'topRSID': 'rs601945', 'p_SMR_multi': 6.190897e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.380995e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_621659', 'Gene': 'C6orf10', 'topRSID': 'rs601945', 'p_SMR_multi': 7.025473e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0003142187}, {'UUID': 'NDD_SMR_genes_all_update_text_621656', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_SMR_multi': 1.108801e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.138573e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_621650', 'Gene': 'C6orf10', 'topRSID': 'rs35265698', 'p_SMR_multi': 1.550106e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 9.935057e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_66150', 'Gene': 'C6orf10', 'topRSID': 'rs2076538', 'p_SMR_multi': 2.832551e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.001796922}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.895 | Q11 | Are there any A1BG SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene A1BG that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'A1BG' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1625 | Q11 | Are there any FUNDC2P4 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene FUNDC2P4 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'FUNDC2P4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.699 | Q11 | Are there any STMN4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Basal Ganglia, Spinalcord, Whole Brain, Cortex, Caudate Basal Ganglia, Hippocampus, Substantia nigra, Hypothalamus, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene STMN4 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'STMN4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1769 | Q11 | Are there any TUBB8P7 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TUBB8P7 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs112089506
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 6.61e-07; HEIDI: 1.9875e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TUBB8P7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1202665', 'Gene': 'TUBB8P7', 'topRSID': 'rs112089506', 'p_SMR_multi': 6.611364e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.1987472}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.301 | Q11 | Are there any FAM162A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene FAM162A that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM162A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1399 | Q11 | Are there any CTC-419K13.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene CTC-419K13.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTC-419K13.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1987 | Q11 | Are there any TLX2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene TLX2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TLX2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.102 | Q11 | Are there any GRIK1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene GRIK1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'GRIK1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.831 | Q11 | Are there any OR1H1P SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene OR1H1P that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'OR1H1P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.359 | Q11 | Are there any SLC25A14P1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Whole Brain and Cerebellum samples tested there are no SNPs within the gene SLC25A14P1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SLC25A14P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.114 | Q11 | Are there any SETD6 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene SETD6 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SETD6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1440 | Q11 | Are there any GATS SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the GATS gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1636988
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.26e-11; HEIDI: 7.1818e-05
• rs2950517
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.44e-10; HEIDI: 4.8612e-05
• rs1617502
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.77e-07; HEIDI: 4.7811e-06
• rs1727133
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 6.13e-07; HEIDI: 2.1806e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GATS' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_585988', 'Gene': 'GATS', 'topRSID': 'rs1636988', 'p_SMR_multi': 1.261396e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.181786e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1495802', 'Gene': 'GATS', 'topRSID': 'rs2950517', 'p_SMR_multi': 2.44138e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.861188e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1392625', 'Gene': 'GATS', 'topRSID': 'rs1617502', 'p_SMR_multi': 1.767868e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 4.781059e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1340318', 'Gene': 'GATS', 'topRSID': 'rs1727133', 'p_SMR_multi': 6.128731e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.2180583}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1840 | Q11 | Are there any CTD-3074O7.5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene CTD-3074O7.5 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTD-3074O7.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.952 | Q11 | Are there any APOE SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the APOE gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs73050293
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.93e-14; HEIDI: 1.5908e-11 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'APOE' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_122464', 'Gene': 'APOE', 'topRSID': 'rs73050293', 'p_SMR_multi': 3.931424e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.590816e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_122463', 'Gene': 'APOE', 'topRSID': 'rs73050293', 'p_SMR_multi': 2.087656e-11, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.50689e-10}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1186 | Q11 | Are there any LRRC40 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene LRRC40 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'LRRC40' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.456 | Q11 | Are there any SCAP SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Multi Ancestry Whole Brain, Hypothalamus, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene SCAP that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'SCAP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.876 | Q11 | Are there any MAPT SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the MAPT gene has 11 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs1981997
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.10e-44; HEIDI: 1.4255e-02
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.19e-44; HEIDI: 3.1134e-12
• rs12373139
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 3.94e-37; HEIDI: -9.9990e+03
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.30e-15; HEIDI: 2.2016e-10
• rs8070723
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.36e-34; HEIDI: 1.3352e-03
• rs2074404
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.07e-21; HEIDI: 6.7829e-05
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.17e-08; HEIDI: -9.9990e+03
• rs415430
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.20e-15; HEIDI: 1.6098e-04
• rs4792891
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.23e-15; HEIDI: 4.8679e-09
• rs11012
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.53e-14; HEIDI: 6.5593e-05
• rs6503455
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.94e-14; HEIDI: 7.9939e-14
• rs173365
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.91e-08; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MAPT' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_560864', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.100115e-44, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01425494}, {'UUID': 'NDD_SMR_genes_all_update_text_560866', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.100115e-44, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041740', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 3.1929999999999995e-44, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.11336e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1041741', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 3.4561940000000002e-43, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.553934e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1041744', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 2.3803009999999997e-42, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.907532e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1041745', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 1.6428750000000002e-39, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.610014e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1444271', 'Gene': 'MAPT', 'topRSID': 'rs12373139', 'p_SMR_multi': 3.936612e-37, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560871', 'Gene': 'MAPT', 'topRSID': 'rs8070723', 'p_SMR_multi': 1.363481e-34, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.001335199}, {'UUID': 'NDD_SMR_genes_all_update_text_560865', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.18903e-31, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.08905337}, {'UUID': 'NDD_SMR_genes_all_update_text_1041752', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 1.2074550000000001e-31, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.222134e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1041736', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 7.307604e-31, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.062933e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1041753', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 5.19183e-29, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.248839e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1041746', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 2.400425e-28, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.182818e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1041734', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 4.544105e-28, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.43666e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_560875', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 4.31748e-27, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.25016e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_560873', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.354128e-26, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.083093e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_560882', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.051081999999999e-26, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.037131e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_560877', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.719349e-26, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 7.60612e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1041747', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 3.272687e-23, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 7.927043e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1646042', 'Gene': 'MAPT', 'topRSID': 'rs2074404', 'p_SMR_multi': 1.066715e-21, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 6.782874e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_560869', 'Gene': 'MAPT', 'topRSID': 'rs8070723', 'p_SMR_multi': 7.657674000000001e-18, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 5.409939e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1041737', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 2.584895e-16, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.480934e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_560872', 'Gene': 'MAPT', 'topRSID': 'rs8070723', 'p_SMR_multi': 3.672562e-16, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041732', 'Gene': 'MAPT', 'topRSID': 'rs415430', 'p_SMR_multi': 1.200666e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001609827}, {'UUID': 'NDD_SMR_genes_all_update_text_560859', 'Gene': 'MAPT', 'topRSID': 'rs4792891', 'p_SMR_multi': 1.232863e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.867928e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_560856', 'Gene': 'MAPT', 'topRSID': 'rs8070723', 'p_SMR_multi': 5.146984e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.003742995}, {'UUID': 'NDD_SMR_genes_all_update_text_560879', 'Gene': 'MAPT', 'topRSID': 'rs8070723', 'p_SMR_multi': 6.079171e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.968213e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_560857', 'Gene': 'MAPT', 'topRSID': 'rs12373139', 'p_SMR_multi': 6.300775e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.201556e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_560858', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.612511e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 8.30113e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_560876', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.765792e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041748', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 1.861224e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0002127885}, {'UUID': 'NDD_SMR_genes_all_update_text_1041749', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 2.796982e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001814462}, {'UUID': 'NDD_SMR_genes_all_update_text_1041735', 'Gene': 'MAPT', 'topRSID': 'rs11012', 'p_SMR_multi': 4.527811e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.559262e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_560880', 'Gene': 'MAPT', 'topRSID': 'rs6503455', 'p_SMR_multi': 9.94001e-14, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 7.99395e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_560870', 'Gene': 'MAPT', 'topRSID': 'rs8070723', 'p_SMR_multi': 9.399525e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.004031737}, {'UUID': 'NDD_SMR_genes_all_update_text_560868', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 9.803227e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560878', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.581687e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041750', 'Gene': 'MAPT', 'topRSID': 'rs415430', 'p_SMR_multi': 2.556759e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004118148}, {'UUID': 'NDD_SMR_genes_all_update_text_560874', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 7.717093e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041742', 'Gene': 'MAPT', 'topRSID': 'rs11012', 'p_SMR_multi': 6.220856e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1366316}, {'UUID': 'NDD_SMR_genes_all_update_text_1041738', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 7.355534e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.00050318}, {'UUID': 'NDD_SMR_genes_all_update_text_560855', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.206067e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041733', 'Gene': 'MAPT', 'topRSID': 'rs415430', 'p_SMR_multi': 1.087261e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560881', 'Gene': 'MAPT', 'topRSID': 'rs6503455', 'p_SMR_multi': 1.241387e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.92587e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1041743', 'Gene': 'MAPT', 'topRSID': 'rs173365', 'p_SMR_multi': 2.913971e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041751', 'Gene': 'MAPT', 'topRSID': 'rs2074404', 'p_SMR_multi': 4.171251e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560867', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 4.711873e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041731', 'Gene': 'MAPT', 'topRSID': 'rs169201', 'p_SMR_multi': 9.094477e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560861', 'Gene': 'MAPT', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.169317e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041739', 'Gene': 'MAPT', 'topRSID': 'rs11012', 'p_SMR_multi': 1.782842e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1579420', 'Gene': 'MAPT', 'topRSID': 'rs17692129', 'p_SMR_multi': 2.304864e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560863', 'Gene': 'MAPT', 'topRSID': 'rs4792891', 'p_SMR_multi': 5.807146e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560862', 'Gene': 'MAPT', 'topRSID': 'rs4792891', 'p_SMR_multi': 1.227493e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560860', 'Gene': 'MAPT', 'topRSID': 'rs4792891', 'p_SMR_multi': 1.503663e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1545 | Q11 | Are there any NDUFAF2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the NDUFAF2 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs2619893
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.32e-08; HEIDI: 4.0245e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NDUFAF2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1556333', 'Gene': 'NDUFAF2', 'topRSID': 'rs2619893', 'p_SMR_multi': 1.315685e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004024545}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1701 | Q11 | Are there any UTF1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex and Cerebellar Hemisphere samples tested there are no SNPs within the gene UTF1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'UTF1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1436 | Q11 | Are there any FAM209A SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene FAM209A that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'FAM209A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.915 | Q11 | Are there any CTC-429P9.4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CTC-429P9.4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTC-429P9.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.310 | Q11 | Are there any AC006946.17 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex, Tibial Nerve, Whole Brain and Cerebellum samples tested there are no SNPs within the gene AC006946.17 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AC006946.17' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1257 | Q11 | Are there any IGHV4-61 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the IGHV4-61 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs12892441
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.56e-08; HEIDI: 2.1513e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'IGHV4-61' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1651677', 'Gene': 'IGHV4-61', 'topRSID': 'rs12892441', 'p_SMR_multi': 4.555003e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2151316}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1409 | Q11 | Are there any FAM131B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the FAM131B gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs13232480
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.03e-07; HEIDI: 7.4923e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM131B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1496068', 'Gene': 'FAM131B', 'topRSID': 'rs13232480', 'p_SMR_multi': 8.029512e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.07492317}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.618 | Q11 | Are there any ACP3 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Basal Ganglia, Hippocampus and Cortex samples tested there are no SNPs within the gene ACP3 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'ACP3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1479 | Q11 | Are there any RP11-50E11.3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RP11-50E11.3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-50E11.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.250 | Q11 | Are there any PRSS36 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the PRSS36 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs55667375
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.46e-07; HEIDI: 1.5829e-02
• Cortex: Adjusted SMR multi-SNP P-value: 2.42e-06; HEIDI: 4.2497e-01
• rs78924645
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.59e-07; HEIDI: 4.1358e-02
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.04e-06; HEIDI: 5.7439e-01
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.10e-06; HEIDI: 1.2325e-02
• rs1549299
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.79e-07; HEIDI: 1.4193e-01
• Cortex: Adjusted SMR multi-SNP P-value: 1.83e-06; HEIDI: 4.4656e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PRSS36' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_109538', 'Gene': 'PRSS36', 'topRSID': 'rs55667375', 'p_SMR_multi': 6.457535e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01582905}, {'UUID': 'NDD_SMR_genes_all_update_text_109537', 'Gene': 'PRSS36', 'topRSID': 'rs78924645', 'p_SMR_multi': 9.593659e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.04135834}, {'UUID': 'NDD_SMR_genes_all_update_text_1610409', 'Gene': 'PRSS36', 'topRSID': 'rs1549299', 'p_SMR_multi': 9.789657e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1419257}, {'UUID': 'NDD_SMR_genes_all_update_text_1174366', 'Gene': 'PRSS36', 'topRSID': 'rs78924645', 'p_SMR_multi': 1.035283e-06, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.5743859}, {'UUID': 'NDD_SMR_genes_all_update_text_1246861', 'Gene': 'PRSS36', 'topRSID': 'rs1549299', 'p_SMR_multi': 1.82609e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.4465604}, {'UUID': 'NDD_SMR_genes_all_update_text_1396182', 'Gene': 'PRSS36', 'topRSID': 'rs78924645', 'p_SMR_multi': 2.103277e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.0123253}, {'UUID': 'NDD_SMR_genes_all_update_text_1111663', 'Gene': 'PRSS36', 'topRSID': 'rs55667375', 'p_SMR_multi': 2.416914e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.4249718}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.734 | Q11 | Are there any CES2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CES2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CES2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.311 | Q11 | Are there any STAG3L5P SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the STAG3L5P gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs6975660
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 5.47e-08; HEIDI: 4.2718e-05
• rs73401443
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.59e-07; HEIDI: 1.6394e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'STAG3L5P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1198851', 'Gene': 'STAG3L5P', 'topRSID': 'rs6975660', 'p_SMR_multi': 5.468728e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 4.271835e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1392627', 'Gene': 'STAG3L5P', 'topRSID': 'rs73401443', 'p_SMR_multi': 1.589447e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.01639354}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.236 | Q11 | Are there any AP001425.14 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AP001425.14 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AP001425.14' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.72 | Q11 | Are there any BNIP2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Skeletal Muscle, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene BNIP2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'BNIP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.896 | Q11 | Are there any AC005493.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC005493.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AC005493.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1754 | Q11 | Are there any RP11-259G18.3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the RP11-259G18.3 gene has 3 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.67e-41; HEIDI: 4.4070e-05
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 2.64e-33; HEIDI: 1.5294e-13
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 8.68e-31; HEIDI: 1.4110e-09
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 3.12e-21; HEIDI: 4.9135e-13
• Cortex: Adjusted SMR multi-SNP P-value: 1.00e-20; HEIDI: 4.4109e-17
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 1.59e-19; HEIDI: 1.2779e-17
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 4.74e-19; HEIDI: 1.5890e-09
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 7.26e-18; HEIDI: 1.5258e-14
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.77e-17; HEIDI: 4.5137e-04
• Hippocampus: Adjusted SMR multi-SNP P-value: 3.10e-17; HEIDI: 4.2235e-15
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 4.72e-17; HEIDI: 2.4414e-10
• Hypothalamus: Adjusted SMR multi-SNP P-value: 5.77e-17; HEIDI: 2.7997e-13
• Amygdala: Adjusted SMR multi-SNP P-value: 2.53e-15; HEIDI: 4.4203e-10
• Substantia nigra: Adjusted SMR multi-SNP P-value: 7.58e-11; HEIDI: 1.4734e-05
• rs12373139
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.70e-36; HEIDI: 1.2946e-18
• rs1981997
• Liver: Adjusted SMR multi-SNP P-value: 1.69e-22; HEIDI: 1.8276e-21
• Cerebellum: Adjusted SMR multi-SNP P-value: 4.27e-22; HEIDI: 3.0603e-21
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.82e-18; HEIDI: 1.1302e-20
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-259G18.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579424', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 2.66922e-41, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.407001e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1684937', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs12373139', 'p_SMR_multi': 3.696455e-36, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.294555e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_1375931', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 2.638097e-33, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 1.529365e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1336293', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 8.684303e-31, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 1.411049e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1478189', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.6939850000000002e-22, 'Omic_tissue': 'Liver', 'p_HEIDI': 1.827604e-21}, {'UUID': 'NDD_SMR_genes_all_update_text_1714158', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs1981997', 'p_SMR_multi': 4.265334e-22, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 3.060336e-21}, {'UUID': 'NDD_SMR_genes_all_update_text_1283705', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 3.119082e-21, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 4.913538e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1264984', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 1.001249e-20, 'Omic_tissue': 'Cortex', 'p_HEIDI': 4.410943e-17}, {'UUID': 'NDD_SMR_genes_all_update_text_1732397', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 1.5889129999999998e-19, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 1.2779040000000003e-17}, {'UUID': 'NDD_SMR_genes_all_update_text_1194219', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 4.740741e-19, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 1.588974e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1596824', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.823399e-18, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 1.1301979999999999e-20}, {'UUID': 'NDD_SMR_genes_all_update_text_1170875', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 7.257474e-18, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 1.525835e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_1646046', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 1.769883e-17, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0004513712}, {'UUID': 'NDD_SMR_genes_all_update_text_1388484', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 3.1035400000000004e-17, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 4.223495e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_1489540', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 4.7246440000000004e-17, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 2.441354e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1464420', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 5.766183e-17, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 2.799671e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1604715', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 2.52599e-15, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 4.420346e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1452484', 'Gene': 'RP11-259G18.3', 'topRSID': 'rs169201', 'p_SMR_multi': 7.584953e-11, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 1.473435e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.712 | Q11 | Are there any HR SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene HR that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'HR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1383 | Q11 | Are there any FBXL19 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene FBXL19 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FBXL19' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1329 | Q11 | Are there any TALDO1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene TALDO1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TALDO1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.624 | Q11 | Are there any UNC93A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene UNC93A that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'UNC93A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1464 | Q11 | Are there any CTD-2532D12.4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CTD-2532D12.4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CTD-2532D12.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1556 | Q11 | Are there any PRDM5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PRDM5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PRDM5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.708 | Q11 | Are there any MAT1A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MAT1A gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1890578
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.08e-08; HEIDI: 2.4687e-03
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.43e-06; HEIDI: 1.5240e-01
• rs10749551
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.28e-07; HEIDI: 9.8136e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MAT1A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_572621', 'Gene': 'MAT1A', 'topRSID': 'rs1890578', 'p_SMR_multi': 2.078454e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002468691}, {'UUID': 'NDD_SMR_genes_all_update_text_85765', 'Gene': 'MAT1A', 'topRSID': 'rs10749551', 'p_SMR_multi': 2.281899e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0009813646}, {'UUID': 'NDD_SMR_genes_all_update_text_85767', 'Gene': 'MAT1A', 'topRSID': 'rs1890578', 'p_SMR_multi': 1.434926e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1524045}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1928 | Q11 | Are there any IGSF6 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene IGSF6 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'IGSF6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.614 | Q11 | Are there any IRX5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene IRX5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'IRX5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.372 | Q11 | Are there any RP5-874C20.3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP5-874C20.3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP5-874C20.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1756 | Q11 | Are there any ORC5 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ORC5 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ORC5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1669 | Q11 | Are there any LARP4B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LARP4B that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LARP4B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.533 | Q11 | Are there any RP11-166N6.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-166N6.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-166N6.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1821 | Q11 | Are there any RP11-126O1.5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-126O1.5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-126O1.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1442 | Q11 | Are there any AK3P3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the AK3P3 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs28483572
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.51e-08; HEIDI: 5.1363e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'AK3P3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1557760', 'Gene': 'AK3P3', 'topRSID': 'rs28483572', 'p_SMR_multi': 9.507488e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.005136264}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.302 | Q11 | Are there any RP5-827C21.4 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Amygdala, Whole Brain and Cerebellum samples tested there are no SNPs within the gene RP5-827C21.4 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP5-827C21.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1016 | Q11 | Are there any PRKRIR SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene PRKRIR that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PRKRIR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1417 | Q11 | Are there any RP5-1030M6.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP5-1030M6.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP5-1030M6.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1567 | Q11 | Are there any AP001432.14 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene AP001432.14 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AP001432.14' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1311 | Q11 | Are there any DND1P1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the DND1P1 gene has 8 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs55974014
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.33e-15; HEIDI: -9.9990e+03
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 4.65e-15; HEIDI: -9.9990e+03
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.52e-14; HEIDI: -9.9990e+03
• Liver: Adjusted SMR multi-SNP P-value: 1.42e-12; HEIDI: 6.9873e-01
• Cortex: Adjusted SMR multi-SNP P-value: 2.29e-12; HEIDI: 7.5025e-01
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.09e-11; HEIDI: 4.3440e-01
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 4.75e-11; HEIDI: 8.7062e-01
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 5.01e-11; HEIDI: 8.2863e-01
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 1.58e-10; HEIDI: 9.1718e-01
• Hypothalamus: Adjusted SMR multi-SNP P-value: 1.98e-10; HEIDI: 8.5280e-01
• Hippocampus: Adjusted SMR multi-SNP P-value: 2.16e-10; HEIDI: 8.6922e-01
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 5.50e-10; HEIDI: 5.1890e-01
• Cerebellum: Adjusted SMR multi-SNP P-value: 9.30e-10; HEIDI: 7.2173e-01
• Amygdala: Adjusted SMR multi-SNP P-value: 2.72e-09; HEIDI: 5.0772e-01
• Substantia nigra: Adjusted SMR multi-SNP P-value: 5.47e-09; HEIDI: 6.0307e-01
• rs199447
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.93e-15; HEIDI: 3.8668e-06
• rs1724390
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.08e-13; HEIDI: 3.7537e-02
• rs575074983
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 3.82e-10; HEIDI: 5.3146e-06
• rs113991678
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.91e-09; HEIDI: 2.7225e-02
• rs1724400
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.18e-08; HEIDI: 1.5096e-01
• rs4327090
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.22e-08; HEIDI: 2.7989e-01
• rs57213017
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.02e-07; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'DND1P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1679562', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 4.32665e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1370540', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 4.645815e-15, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_948856', 'Gene': 'DND1P1', 'topRSID': 'rs199447', 'p_SMR_multi': 4.92908e-15, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.866787e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1328927', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.51557e-14, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_491080', 'Gene': 'DND1P1', 'topRSID': 'rs1724390', 'p_SMR_multi': 3.078724e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.03753698}, {'UUID': 'NDD_SMR_genes_all_update_text_1476423', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.423253e-12, 'Omic_tissue': 'Liver', 'p_HEIDI': 0.6987305}, {'UUID': 'NDD_SMR_genes_all_update_text_1262221', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.285615e-12, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.7502548}, {'UUID': 'NDD_SMR_genes_all_update_text_1594920', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.093413e-11, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.4344016}, {'UUID': 'NDD_SMR_genes_all_update_text_1281350', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 4.749159e-11, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.8706195}, {'UUID': 'NDD_SMR_genes_all_update_text_1730060', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 5.008634e-11, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.8286284}, {'UUID': 'NDD_SMR_genes_all_update_text_1168832', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.576563e-10, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.9171828}, {'UUID': 'NDD_SMR_genes_all_update_text_1462890', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 1.9788e-10, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.852796}, {'UUID': 'NDD_SMR_genes_all_update_text_1386988', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.161785e-10, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 0.8692197}, {'UUID': 'NDD_SMR_genes_all_update_text_1242266', 'Gene': 'DND1P1', 'topRSID': 'rs575074983', 'p_SMR_multi': 3.818601e-10, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 5.314638e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1488136', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 5.499578e-10, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.5188977}, {'UUID': 'NDD_SMR_genes_all_update_text_1710345', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 9.299729e-10, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.7217328}, {'UUID': 'NDD_SMR_genes_all_update_text_1603773', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 2.717583e-09, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 0.5077181}, {'UUID': 'NDD_SMR_genes_all_update_text_1564780', 'Gene': 'DND1P1', 'topRSID': 'rs113991678', 'p_SMR_multi': 3.906653e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02722508}, {'UUID': 'NDD_SMR_genes_all_update_text_1451660', 'Gene': 'DND1P1', 'topRSID': 'rs55974014', 'p_SMR_multi': 5.468392e-09, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 0.603074}, {'UUID': 'NDD_SMR_genes_all_update_text_1191167', 'Gene': 'DND1P1', 'topRSID': 'rs1724400', 'p_SMR_multi': 1.183855e-08, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.150965}, {'UUID': 'NDD_SMR_genes_all_update_text_1640217', 'Gene': 'DND1P1', 'topRSID': 'rs4327090', 'p_SMR_multi': 6.216822e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.2798898}, {'UUID': 'NDD_SMR_genes_all_update_text_491081', 'Gene': 'DND1P1', 'topRSID': 'rs57213017', 'p_SMR_multi': 1.022103e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.862 | Q11 | Are there any SEMA4G SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene SEMA4G that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SEMA4G' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.591 | Q11 | Are there any KLRC4-KLRK1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene KLRC4-KLRK1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KLRC4-KLRK1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.485 | Q11 | Are there any MLH3 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene MLH3 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MLH3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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