uuid stringlengths 4 8 | template_uuid stringclasses 40 values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 138 627 | execution_results stringlengths 2 1.14M | query_type stringclasses 2 values | sql_category stringclasses 26 values | bio_category stringclasses 14 values |
|---|---|---|---|---|---|---|---|---|
Q11.1473 | Q11 | Are there any RP11-13K12.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Anterior Cingulate Cortex BA24, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-13K12.1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-13K12.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1784 | Q11 | Are there any FYTTD1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene FYTTD1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FYTTD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.644 | Q11 | Are there any RP11-598F7.5 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellar Hemisphere and Cerebellum samples tested there are no SNPs within the gene RP11-598F7.5 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-598F7.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.357 | Q11 | Are there any AP4M1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Liver and Nucleus Accumbens Basal samples tested there are no SNPs within the gene AP4M1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'AP4M1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1128 | Q11 | Are there any HRH2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene HRH2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'HRH2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.439 | Q11 | Are there any GPR32 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene GPR32 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'GPR32' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1121 | Q11 | Are there any TRBV3-1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex and Whole Blood samples tested there are no SNPs within the gene TRBV3-1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'TRBV3-1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1103 | Q11 | Are there any LRRC37A4P SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the LRRC37A4P gene has 17 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs570200944
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 3.01e-15; HEIDI: 6.2418e-01
• rs112746008
• Whole Brain: Adjusted SMR multi-SNP P-value: 5.39e-15; HEIDI: 5.4471e-04
• rs62065450
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 7.19e-15; HEIDI: 1.4371e-01
• rs1724390
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.11e-14; HEIDI: -9.9990e+03
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 6.93e-14; HEIDI: -9.9990e+03
• rs757055
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.18e-13; HEIDI: -9.9990e+03
• rs1991556
• Cerebellum: Adjusted SMR multi-SNP P-value: 5.01e-13; HEIDI: 3.5028e-02
• rs62062283
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 6.23e-13; HEIDI: -9.9990e+03
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.36e-11; HEIDI: -9.9990e+03
• rs62063271
• Cortex: Adjusted SMR multi-SNP P-value: 1.12e-12; HEIDI: -9.9990e+03
• rs62062813
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.24e-12; HEIDI: -9.9990e+03
• rs2942166
• Liver: Adjusted SMR multi-SNP P-value: 1.63e-12; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'LRRC37A4P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1242262', 'Gene': 'LRRC37A4P', 'topRSID': 'rs570200944', 'p_SMR_multi': 3.008197e-15, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.624181}, {'UUID': 'NDD_SMR_genes_all_update_text_1640214', 'Gene': 'LRRC37A4P', 'topRSID': 'rs112746008', 'p_SMR_multi': 5.393237e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0005447143}, {'UUID': 'NDD_SMR_genes_all_update_text_1435914', 'Gene': 'LRRC37A4P', 'topRSID': 'rs62065450', 'p_SMR_multi': 7.192293e-15, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.1437094}, {'UUID': 'NDD_SMR_genes_all_update_text_1679559', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1724390', 'p_SMR_multi': 1.113045e-14, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1328924', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1724390', 'p_SMR_multi': 6.929096e-14, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1370537', 'Gene': 'LRRC37A4P', 'topRSID': 'rs757055', 'p_SMR_multi': 1.183314e-13, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1710342', 'Gene': 'LRRC37A4P', 'topRSID': 'rs1991556', 'p_SMR_multi': 5.010673e-13, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.0350284}, {'UUID': 'NDD_SMR_genes_all_update_text_1730058', 'Gene': 'LRRC37A4P', 'topRSID': 'rs62062283', 'p_SMR_multi': 6.227745e-13, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1262219', 'Gene': 'LRRC37A4P', 'topRSID': 'rs62063271', 'p_SMR_multi': 1.116506e-12, 'Omic_tissue': 'Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1281349', 'Gene': 'LRRC37A4P', 'topRSID': 'rs62062813', 'p_SMR_multi': 1.242453e-12, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1476420', 'Gene': 'LRRC37A4P', 'topRSID': 'rs2942166', 'p_SMR_multi': 1.630765e-12, 'Omic_tissue': 'Liver', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1168831', 'Gene': 'LRRC37A4P', 'topRSID': 'rs62057151', 'p_SMR_multi': 2.026026e-12, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.7481131}, {'UUID': 'NDD_SMR_genes_all_update_text_1191164', 'Gene': 'LRRC37A4P', 'topRSID': 'rs62055496', 'p_SMR_multi': 2.240779e-12, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1462889', 'Gene': 'LRRC37A4P', 'topRSID': 'rs112155389', 'p_SMR_multi': 5.015928e-12, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1386986', 'Gene': 'LRRC37A4P', 'topRSID': 'rs62060768', 'p_SMR_multi': 5.270065e-12, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1488135', 'Gene': 'LRRC37A4P', 'topRSID': 'rs62060768', 'p_SMR_multi': 5.64783e-12, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1594919', 'Gene': 'LRRC37A4P', 'topRSID': 'rs62062283', 'p_SMR_multi': 2.363754e-11, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1451658', 'Gene': 'LRRC37A4P', 'topRSID': 'rs58879558', 'p_SMR_multi': 2.717363e-11, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 0.131708}, {'UUID': 'NDD_SMR_genes_all_update_text_1603772', 'Gene': 'LRRC37A4P', 'topRSID': 'rs112411928', 'p_SMR_multi': 5.687577e-11, 'Omic_tissue': 'Amygdala', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1564777', 'Gene': 'LRRC37A4P', 'topRSID': 'rs112560196', 'p_SMR_multi': 5.646241e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001341234}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1348 | Q11 | Are there any COL6A1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene COL6A1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'COL6A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.597 | Q11 | Are there any SULT1C4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood, Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Amygdala and Whole Brain samples tested there are no SNPs within the gene SULT1C4 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SULT1C4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1368 | Q11 | Are there any BHLHA15 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Hippocampus, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene BHLHA15 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'BHLHA15' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1401 | Q11 | Are there any OR2A2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Cortex samples tested there are no SNPs within the gene OR2A2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'OR2A2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.753 | Q11 | Are there any CD82 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CD82 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CD82' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.259 | Q11 | Are there any NUPL2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the NUPL2 gene has 8 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs1637221
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.99e-08; HEIDI: 9.4689e-01
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 3.31e-08; HEIDI: 2.5531e-01
• rs1881200
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 5.93e-08; HEIDI: 7.8287e-02
• rs28673077
• Whole Brain: Adjusted SMR multi-SNP P-value: 6.17e-08; HEIDI: 3.1215e-06
• rs6970694
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.83e-07; HEIDI: 7.2287e-02
• rs858289
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.94e-07; HEIDI: 6.3951e-01
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 4.03e-07; HEIDI: 6.0680e-01
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 1.34e-06; HEIDI: 9.6810e-01
• rs6962213
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 7.62e-07; HEIDI: 1.4059e-02
• rs1881201
• Cortex: Adjusted SMR multi-SNP P-value: 8.47e-07; HEIDI: 5.2264e-01
• rs2141307
• Hypothalamus: Adjusted SMR multi-SNP P-value: 2.90e-06; HEIDI: 1.8773e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'NUPL2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1557762', 'Gene': 'NUPL2', 'topRSID': 'rs1637221', 'p_SMR_multi': 1.986696e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.9468852}, {'UUID': 'NDD_SMR_genes_all_update_text_1431547', 'Gene': 'NUPL2', 'topRSID': 'rs1637221', 'p_SMR_multi': 3.310267e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.2553095}, {'UUID': 'NDD_SMR_genes_all_update_text_1237814', 'Gene': 'NUPL2', 'topRSID': 'rs1881200', 'p_SMR_multi': 5.927793e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.07828704}, {'UUID': 'NDD_SMR_genes_all_update_text_1636965', 'Gene': 'NUPL2', 'topRSID': 'rs28673077', 'p_SMR_multi': 6.169894e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.1215e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1324772', 'Gene': 'NUPL2', 'topRSID': 'rs6970694', 'p_SMR_multi': 1.827718e-07, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.07228731}, {'UUID': 'NDD_SMR_genes_all_update_text_1708094', 'Gene': 'NUPL2', 'topRSID': 'rs858289', 'p_SMR_multi': 2.943089e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.6395146}, {'UUID': 'NDD_SMR_genes_all_update_text_1189326', 'Gene': 'NUPL2', 'topRSID': 'rs858289', 'p_SMR_multi': 4.034196e-07, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.6067969}, {'UUID': 'NDD_SMR_genes_all_update_text_1367507', 'Gene': 'NUPL2', 'topRSID': 'rs6962213', 'p_SMR_multi': 7.620288e-07, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.01405869}, {'UUID': 'NDD_SMR_genes_all_update_text_1260546', 'Gene': 'NUPL2', 'topRSID': 'rs1881201', 'p_SMR_multi': 8.474918e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.5226387}, {'UUID': 'NDD_SMR_genes_all_update_text_1167542', 'Gene': 'NUPL2', 'topRSID': 'rs858289', 'p_SMR_multi': 1.340795e-06, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.9681001}, {'UUID': 'NDD_SMR_genes_all_update_text_1461948', 'Gene': 'NUPL2', 'topRSID': 'rs2141307', 'p_SMR_multi': 2.903356e-06, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 0.01877344}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1687 | Q11 | Are there any SHROOM3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the SHROOM3 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs59136511
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.14e-07; HEIDI: 2.2609e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SHROOM3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_998381', 'Gene': 'SHROOM3', 'topRSID': 'rs59136511', 'p_SMR_multi': 5.144308e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02260865}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1723 | Q11 | Are there any AC025335.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC025335.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AC025335.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.544 | Q11 | Are there any KBTBD3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene KBTBD3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'KBTBD3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.792 | Q11 | Are there any ZCCHC7 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene ZCCHC7 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ZCCHC7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1484 | Q11 | Are there any RBAK-RBAKDN SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RBAK-RBAKDN that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RBAK-RBAKDN' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.420 | Q11 | Are there any RP3-402G11.26 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Frontal Cortex, Cerebellar Hemisphere, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP3-402G11.26 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP3-402G11.26' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1849 | Q11 | Are there any LRRC37A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the LRRC37A gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2668632
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.23e-08; HEIDI: 4.0459e-03
• rs383241
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 6.75e-08; HEIDI: -9.9990e+03
• rs2696466
• Cortex: Adjusted SMR multi-SNP P-value: 9.23e-08; HEIDI: 6.3190e-01
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.13e-06; HEIDI: 5.1906e-01
• rs62062280
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.26e-08; HEIDI: 3.1260e-02
• rs7225002
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 2.39e-07; HEIDI: 4.4649e-01
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.55e-06; HEIDI: 1.7689e-04
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 2.92e-06; HEIDI: 9.6449e-02
• rs4510068
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.06e-06; HEIDI: 6.2624e-01
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.61e-06; HEIDI: 8.1075e-02
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 2.24e-06; HEIDI: 4.7819e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'LRRC37A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1203016', 'Gene': 'LRRC37A', 'topRSID': 'rs2668632', 'p_SMR_multi': 1.228585e-08, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.004045895}, {'UUID': 'NDD_SMR_genes_all_update_text_1396751', 'Gene': 'LRRC37A', 'topRSID': 'rs383241', 'p_SMR_multi': 6.752554e-08, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1106831', 'Gene': 'LRRC37A', 'topRSID': 'rs2696466', 'p_SMR_multi': 9.232231e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.6318983}, {'UUID': 'NDD_SMR_genes_all_update_text_1610870', 'Gene': 'LRRC37A', 'topRSID': 'rs62062280', 'p_SMR_multi': 9.258575e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.03126041}, {'UUID': 'NDD_SMR_genes_all_update_text_1291766', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 2.387945e-07, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.4464903}, {'UUID': 'NDD_SMR_genes_all_update_text_1690051', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_SMR_multi': 1.056725e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.6262373}, {'UUID': 'NDD_SMR_genes_all_update_text_1343159', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 1.548118e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.0001768944}, {'UUID': 'NDD_SMR_genes_all_update_text_1652503', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_SMR_multi': 1.613978e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.08107542}, {'UUID': 'NDD_SMR_genes_all_update_text_2658', 'Gene': 'LRRC37A', 'topRSID': 'rs2696466', 'p_SMR_multi': 2.127122e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.519064}, {'UUID': 'NDD_SMR_genes_all_update_text_1174603', 'Gene': 'LRRC37A', 'topRSID': 'rs4510068', 'p_SMR_multi': 2.236244e-06, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.4781917}, {'UUID': 'NDD_SMR_genes_all_update_text_1157205', 'Gene': 'LRRC37A', 'topRSID': 'rs7225002', 'p_SMR_multi': 2.918089e-06, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.09644851}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1920 | Q11 | Are there any RP11-162A12.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene RP11-162A12.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-162A12.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1099 | Q11 | Are there any SS18L1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SS18L1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SS18L1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.845 | Q11 | Are there any GIGYF1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the GIGYF1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs506597
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.41e-08; HEIDI: 6.6507e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GIGYF1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495820', 'Gene': 'GIGYF1', 'topRSID': 'rs506597', 'p_SMR_multi': 1.409553e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.6650747}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.68 | Q11 | Are there any C7orf68 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene C7orf68 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'C7orf68' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1698 | Q11 | Are there any IDUA SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the IDUA gene has 15 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs1051613
• Whole Brain: Adjusted SMR multi-SNP P-value: 4.55e-13; HEIDI: 2.2131e-05
• rs6599388
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.87e-12; HEIDI: 1.9149e-02
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.39e-09; HEIDI: 5.6506e-03
• rs11724804
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.50e-11; HEIDI: 2.1160e-03
• rs11936407
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.16e-09; HEIDI: 4.7751e-12
• rs11248061
• Whole Brain: Adjusted SMR multi-SNP P-value: 3.55e-09; HEIDI: 8.5096e-02
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 3.54e-08; HEIDI: 1.9435e-03
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.08e-07; HEIDI: 2.4358e-02
• rs10010999
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.21e-08; HEIDI: 1.0798e-04
• rs62294519
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.00e-08; HEIDI: 5.2135e-02
• rs115435541
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.12e-08; HEIDI: 2.6075e-07
• rs73211813
• Cortex: Adjusted SMR multi-SNP P-value: 2.39e-08; HEIDI: 3.8647e-02
• rs4690219
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.05e-07; HEIDI: 3.0223e-07
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'IDUA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_429873', 'Gene': 'IDUA', 'topRSID': 'rs1051613', 'p_SMR_multi': 4.554749e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 2.213052e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_429874', 'Gene': 'IDUA', 'topRSID': 'rs1051613', 'p_SMR_multi': 1.717529e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.400598e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_429872', 'Gene': 'IDUA', 'topRSID': 'rs6599388', 'p_SMR_multi': 1.871471e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.01914885}, {'UUID': 'NDD_SMR_genes_all_update_text_429870', 'Gene': 'IDUA', 'topRSID': 'rs6599388', 'p_SMR_multi': 3.767513e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.008214192}, {'UUID': 'NDD_SMR_genes_all_update_text_1555642', 'Gene': 'IDUA', 'topRSID': 'rs11724804', 'p_SMR_multi': 3.500513e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002115975}, {'UUID': 'NDD_SMR_genes_all_update_text_429871', 'Gene': 'IDUA', 'topRSID': 'rs1051613', 'p_SMR_multi': 8.179958e-11, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.04819888}, {'UUID': 'NDD_SMR_genes_all_update_text_996313', 'Gene': 'IDUA', 'topRSID': 'rs11936407', 'p_SMR_multi': 1.158943e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.775076e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1366483', 'Gene': 'IDUA', 'topRSID': 'rs6599388', 'p_SMR_multi': 1.389369e-09, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.005650594}, {'UUID': 'NDD_SMR_genes_all_update_text_429875', 'Gene': 'IDUA', 'topRSID': 'rs11248061', 'p_SMR_multi': 3.549245e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.08509635}, {'UUID': 'NDD_SMR_genes_all_update_text_429877', 'Gene': 'IDUA', 'topRSID': 'rs11248061', 'p_SMR_multi': 1.161936e-08, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1446274}, {'UUID': 'NDD_SMR_genes_all_update_text_996317', 'Gene': 'IDUA', 'topRSID': 'rs10010999', 'p_SMR_multi': 1.210406e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001079832}, {'UUID': 'NDD_SMR_genes_all_update_text_996316', 'Gene': 'IDUA', 'topRSID': 'rs62294519', 'p_SMR_multi': 2.002718e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05213469}, {'UUID': 'NDD_SMR_genes_all_update_text_996312', 'Gene': 'IDUA', 'topRSID': 'rs115435541', 'p_SMR_multi': 2.118233e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.60753e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1140277', 'Gene': 'IDUA', 'topRSID': 'rs73211813', 'p_SMR_multi': 2.390642e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.03864672}, {'UUID': 'NDD_SMR_genes_all_update_text_1323353', 'Gene': 'IDUA', 'topRSID': 'rs11248061', 'p_SMR_multi': 3.538938e-08, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.00194353}, {'UUID': 'NDD_SMR_genes_all_update_text_429865', 'Gene': 'IDUA', 'topRSID': 'rs4690219', 'p_SMR_multi': 1.050752e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.02227e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_996322', 'Gene': 'IDUA', 'topRSID': 'rs11248060', 'p_SMR_multi': 1.466363e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.07626291}, {'UUID': 'NDD_SMR_genes_all_update_text_429876', 'Gene': 'IDUA', 'topRSID': 'rs11248061', 'p_SMR_multi': 1.66957e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.09144947}, {'UUID': 'NDD_SMR_genes_all_update_text_1675612', 'Gene': 'IDUA', 'topRSID': 'rs11248061', 'p_SMR_multi': 4.08187e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02435755}, {'UUID': 'NDD_SMR_genes_all_update_text_996314', 'Gene': 'IDUA', 'topRSID': 'rs6964', 'p_SMR_multi': 1.284951e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001024977}, {'UUID': 'NDD_SMR_genes_all_update_text_429866', 'Gene': 'IDUA', 'topRSID': 'rs3806756', 'p_SMR_multi': 2.018075e-06, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 8.91352e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_996315', 'Gene': 'IDUA', 'topRSID': 'rs188911015', 'p_SMR_multi': 2.300619e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.380483e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1430186', 'Gene': 'IDUA', 'topRSID': 'rs4690326', 'p_SMR_multi': 2.398698e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.868522e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1733 | Q11 | Are there any PTENP1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Prefrontal Cortex, Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene PTENP1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PTENP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.380 | Q11 | Are there any ZNF780A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Liver, Whole Blood and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ZNF780A that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ZNF780A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.240 | Q11 | Are there any RP1-90J4.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Liver samples tested there are no SNPs within the gene RP1-90J4.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP1-90J4.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.257 | Q11 | Are there any PCDHGB7 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PCDHGB7 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PCDHGB7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1032 | Q11 | Are there any TMED3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Amygdala samples tested there are no SNPs within the gene TMED3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TMED3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.30 | Q11 | Are there any PRSS41 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene PRSS41 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'PRSS41' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.293 | Q11 | Are there any EFCAB1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene EFCAB1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'EFCAB1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1886 | Q11 | Are there any GAST SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene GAST that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'GAST' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1823 | Q11 | Are there any AC021188.4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene AC021188.4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'AC021188.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.620 | Q11 | Are there any TRIM31 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TRIM31 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs139747027
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.09e-07; HEIDI: 7.7038e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRIM31' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620227', 'Gene': 'TRIM31', 'topRSID': 'rs139747027', 'p_SMR_multi': 6.086832e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.07703764}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1667 | Q11 | Are there any CTTNBP2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CTTNBP2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTTNBP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.850 | Q11 | Are there any STAG3L5P-PVRIG2P-PILRB SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene STAG3L5P-PVRIG2P-PILRB that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'STAG3L5P-PVRIG2P-PILRB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.215 | Q11 | Are there any FARP2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Anterior Cingulate Cortex BA24 and Nucleus Accumbens Basal samples tested there are no SNPs within the gene FARP2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FARP2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.524 | Q11 | Are there any PRR11 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene PRR11 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PRR11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.477 | Q11 | Are there any TREML5P SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TREML5P gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs6458200
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.12e-10; HEIDI: 2.7424e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TREML5P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1494872', 'Gene': 'TREML5P', 'topRSID': 'rs6458200', 'p_SMR_multi': 1.116296e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0002742431}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1327 | Q11 | Are there any SRSF9 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood, Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Brain samples tested there are no SNPs within the gene SRSF9 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SRSF9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1433 | Q11 | Are there any UFSP1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the UFSP1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs7783457
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.12e-09; HEIDI: 6.1776e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'UFSP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495826', 'Gene': 'UFSP1', 'topRSID': 'rs7783457', 'p_SMR_multi': 5.120394e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.6177553}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.123 | Q11 | Are there any KIAA1841 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Cortex, Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene KIAA1841 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'KIAA1841' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1351 | Q11 | Are there any TMEM74 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex and Skeletal Muscle samples tested there are no SNPs within the gene TMEM74 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'TMEM74' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1942 | Q11 | Are there any IGHV3-74 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene IGHV3-74 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'IGHV3-74' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1371 | Q11 | Are there any IGLC3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Liver and Whole Blood samples tested there are no SNPs within the gene IGLC3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'IGLC3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1171 | Q11 | Are there any FRS3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cerebellar Hemisphere, Caudate Basal Ganglia, Tibial Nerve, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene FRS3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FRS3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.138 | Q11 | Are there any RP11-418J17.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-418J17.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-418J17.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1134 | Q11 | Are there any ZFP57 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ZFP57 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2747429
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.31e-06; HEIDI: 2.5189e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZFP57' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_619934', 'Gene': 'ZFP57', 'topRSID': 'rs2747429', 'p_SMR_multi': 2.309027e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2518906}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1874 | Q11 | Are there any FAHD2A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene FAHD2A that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'FAHD2A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1241 | Q11 | Are there any CCDC37 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CCDC37 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CCDC37' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1338 | Q11 | Are there any RP11-563N12.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene RP11-563N12.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-563N12.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.958 | Q11 | Are there any CTD-2541J13.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellar Hemisphere samples tested there are no SNPs within the gene CTD-2541J13.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTD-2541J13.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.929 | Q11 | Are there any AC020907.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC020907.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AC020907.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.112 | Q11 | Are there any WDR81 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the WDR81 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs62090040
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.20e-06; HEIDI: 2.3112e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'WDR81' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_588665', 'Gene': 'WDR81', 'topRSID': 'rs62090040', 'p_SMR_multi': 1.198628e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02311191}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1240 | Q11 | Are there any KRTAP10-9 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene KRTAP10-9 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KRTAP10-9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1921 | Q11 | Are there any TPR SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene TPR that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TPR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1963 | Q11 | Are there any RP11-259G18.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-259G18.2 gene has 8 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs199528
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.22e-07; HEIDI: 1.6323e-01
• rs55974014
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.29e-07; HEIDI: -9.9990e+03
• rs2532233
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.99e-07; HEIDI: 1.9749e-02
• rs62056812
• Cerebellum: Adjusted SMR multi-SNP P-value: 9.15e-07; HEIDI: 4.1087e-01
• rs2696673
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.80e-06; HEIDI: 8.7247e-01
• rs199533
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 2.51e-06; HEIDI: 4.5664e-01
• rs62055938
• Liver: Adjusted SMR multi-SNP P-value: 2.71e-06; HEIDI: 5.1283e-01
• rs17763086
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 2.95e-06; HEIDI: 7.1768e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-259G18.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1610867', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs199528', 'p_SMR_multi': 1.217741e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1632318}, {'UUID': 'NDD_SMR_genes_all_update_text_1652500', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs55974014', 'p_SMR_multi': 5.286305e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1502450', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs2532233', 'p_SMR_multi': 5.992863e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01974858}, {'UUID': 'NDD_SMR_genes_all_update_text_1690047', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs62056812', 'p_SMR_multi': 9.150679e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.4108652}, {'UUID': 'NDD_SMR_genes_all_update_text_1291762', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs2696673', 'p_SMR_multi': 1.802782e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.8724702}, {'UUID': 'NDD_SMR_genes_all_update_text_1480160', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs199533', 'p_SMR_multi': 2.511431e-06, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.4566359}, {'UUID': 'NDD_SMR_genes_all_update_text_1466647', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs62055938', 'p_SMR_multi': 2.710665e-06, 'Omic_tissue': 'Liver', 'p_HEIDI': 0.5128316}, {'UUID': 'NDD_SMR_genes_all_update_text_1174599', 'Gene': 'RP11-259G18.2', 'topRSID': 'rs17763086', 'p_SMR_multi': 2.948594e-06, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.7176842}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.214 | Q11 | Are there any ST7L SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Basal Ganglia, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ST7L that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'ST7L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.999 | Q11 | Are there any NAA20 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene NAA20 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'NAA20' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1269 | Q11 | Are there any TXNDC5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene TXNDC5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TXNDC5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.592 | Q11 | Are there any PARD3-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene PARD3-AS1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'PARD3-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1391 | Q11 | Are there any CDC14A SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Liver samples tested there are no SNPs within the gene CDC14A that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CDC14A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1450 | Q11 | Are there any ANKRD11 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ANKRD11 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ANKRD11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.279 | Q11 | Are there any CTD-2228A4.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Hippocampus, Hypothalamus, Anterior Cingulate Cortex BA24, Amygdala, Whole Brain, Whole Blood, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CTD-2228A4.1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTD-2228A4.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1507 | Q11 | Are there any YPEL3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the YPEL3 gene has 4 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs9932605
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.16e-09; HEIDI: 1.1287e-02
• rs73530179
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 6.50e-08; HEIDI: 9.1041e-03
• rs12444973
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.35e-07; HEIDI: 9.9437e-09
• Cerebellum: Adjusted SMR multi-SNP P-value: 7.25e-07; HEIDI: 7.8083e-02
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.41e-06; HEIDI: 6.0928e-02
• rs7201518
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.37e-07; HEIDI: 8.6770e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'YPEL3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501444', 'Gene': 'YPEL3', 'topRSID': 'rs9932605', 'p_SMR_multi': 1.157442e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01128746}, {'UUID': 'NDD_SMR_genes_all_update_text_1291221', 'Gene': 'YPEL3', 'topRSID': 'rs73530179', 'p_SMR_multi': 6.499622e-08, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.009104112}, {'UUID': 'NDD_SMR_genes_all_update_text_1396164', 'Gene': 'YPEL3', 'topRSID': 'rs12444973', 'p_SMR_multi': 1.349949e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 9.943744e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_577437', 'Gene': 'YPEL3', 'topRSID': 'rs7201518', 'p_SMR_multi': 4.369101e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.08676983}, {'UUID': 'NDD_SMR_genes_all_update_text_1689748', 'Gene': 'YPEL3', 'topRSID': 'rs12444973', 'p_SMR_multi': 7.254515e-07, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.07808286}, {'UUID': 'NDD_SMR_genes_all_update_text_1174357', 'Gene': 'YPEL3', 'topRSID': 'rs12444973', 'p_SMR_multi': 1.406057e-06, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.06092829}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1328 | Q11 | Are there any IGKV1-16 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene IGKV1-16 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'IGKV1-16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1271 | Q11 | Are there any MINK1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MINK1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs3966782
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.47e-06; HEIDI: 1.4446e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MINK1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501910', 'Gene': 'MINK1', 'topRSID': 'rs3966782', 'p_SMR_multi': 1.46809e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01444606}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1820 | Q11 | Are there any ATP10B SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ATP10B that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ATP10B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.273 | Q11 | Are there any EPHA1-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the EPHA1-AS1 gene has 5 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs3935067
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.91e-11; HEIDI: 3.7193e-02
• rs11769559
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.89e-11; HEIDI: 5.4766e-02
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.34e-09; HEIDI: 5.0508e-02
• rs10226151
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.94e-09; HEIDI: 3.2471e-05
• rs75045569
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.94e-09; HEIDI: 1.6353e-01
• rs1404650
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.03e-07; HEIDI: 1.9527e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'EPHA1-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1496073', 'Gene': 'EPHA1-AS1', 'topRSID': 'rs3935067', 'p_SMR_multi': 3.914159e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03719332}, {'UUID': 'NDD_SMR_genes_all_update_text_1649764', 'Gene': 'EPHA1-AS1', 'topRSID': 'rs11769559', 'p_SMR_multi': 7.887443e-11, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05476588}, {'UUID': 'NDD_SMR_genes_all_update_text_1287997', 'Gene': 'EPHA1-AS1', 'topRSID': 'rs11769559', 'p_SMR_multi': 1.341267e-09, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.05050774}, {'UUID': 'NDD_SMR_genes_all_update_text_75161', 'Gene': 'EPHA1-AS1', 'topRSID': 'rs10226151', 'p_SMR_multi': 2.944914e-09, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 3.247074e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_587067', 'Gene': 'EPHA1-AS1', 'topRSID': 'rs75045569', 'p_SMR_multi': 6.942181e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1635299}, {'UUID': 'NDD_SMR_genes_all_update_text_587068', 'Gene': 'EPHA1-AS1', 'topRSID': 'rs1404650', 'p_SMR_multi': 2.026225e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001952697}, {'UUID': 'NDD_SMR_genes_all_update_text_587069', 'Gene': 'EPHA1-AS1', 'topRSID': 'rs1404650', 'p_SMR_multi': 2.382327e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001793992}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1863 | Q11 | Are there any GALNT14 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene GALNT14 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'GALNT14' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.578 | Q11 | Are there any RP11-259G18.1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hypothalamus, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-259G18.1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-259G18.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.638 | Q11 | Are there any ARAP1-AS2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene ARAP1-AS2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ARAP1-AS2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.713 | Q11 | Are there any HIGD2B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene HIGD2B that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'HIGD2B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1529 | Q11 | Are there any CSTF1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CSTF1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs6024857
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.11e-10; HEIDI: 1.2547e-05 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CSTF1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1504669', 'Gene': 'CSTF1', 'topRSID': 'rs6024857', 'p_SMR_multi': 2.112683e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.254673e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.627 | Q11 | Are there any SHPRH SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SHPRH that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SHPRH' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1991 | Q11 | Are there any LA16c-381G6.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LA16c-381G6.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'LA16c-381G6.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.813 | Q11 | Are there any AC006435.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC006435.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AC006435.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.309 | Q11 | Are there any CTD-2020K17.1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the CTD-2020K17.1 gene has 2 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs62063276
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.99e-08; HEIDI: 8.1330e-01
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.55e-07; HEIDI: 9.0697e-01
• rs1358071
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 2.44e-06; HEIDI: 1.0007e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTD-2020K17.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1710336', 'Gene': 'CTD-2020K17.1', 'topRSID': 'rs62063276', 'p_SMR_multi': 8.988243e-08, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.8132973}, {'UUID': 'NDD_SMR_genes_all_update_text_1435909', 'Gene': 'CTD-2020K17.1', 'topRSID': 'rs62063276', 'p_SMR_multi': 2.545914e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.9069703}, {'UUID': 'NDD_SMR_genes_all_update_text_1191158', 'Gene': 'CTD-2020K17.1', 'topRSID': 'rs1358071', 'p_SMR_multi': 2.43574e-06, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 0.1000749}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.550 | Q11 | Are there any CAPN10 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Putamen Basal Ganglia samples tested there are no SNPs within the gene CAPN10 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CAPN10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1606 | Q11 | Are there any MUC12 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene MUC12 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'MUC12' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1743 | Q11 | Are there any SH3TC2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene SH3TC2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SH3TC2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.50 | Q11 | Are there any RP11-646J21.6 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-646J21.6 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-646J21.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1089 | Q11 | Are there any EVA1B SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene EVA1B that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'EVA1B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1674 | Q11 | Are there any ZNF193 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ZNF193 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ZNF193' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1697 | Q11 | Are there any IGLL3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene IGLL3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'IGLL3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.686 | Q11 | Are there any RP11-83C7.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-83C7.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-83C7.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1485 | Q11 | Are there any SRPK2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene SRPK2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SRPK2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1455 | Q11 | Are there any U8 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene U8 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'U8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1486 | Q11 | Are there any FSD1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene FSD1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FSD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1292 | Q11 | Are there any DBF4B SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene DBF4B that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'DBF4B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1232 | Q11 | Are there any RP11-257K9.8 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-257K9.8 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-257K9.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.525 | Q11 | Are there any RP11-666A20.4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex and Tibial Nerve samples tested there are no SNPs within the gene RP11-666A20.4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-666A20.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1654 | Q11 | Are there any RP3-439F8.1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP3-439F8.1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP3-439F8.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.908 | Q11 | Are there any RP11-173B14.4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Whole Blood and Whole Brain samples tested there are no SNPs within the gene RP11-173B14.4 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-173B14.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1904 | Q11 | Are there any UQCR11 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene UQCR11 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'UQCR11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1242 | Q11 | Are there any ANLN SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene ANLN that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ANLN' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.24 | Q11 | Are there any SNORA33 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene SNORA33 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SNORA33' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.779 | Q11 | Are there any LHFPL3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene LHFPL3 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LHFPL3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.