uuid stringlengths 4 8 | template_uuid stringclasses 40 values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 138 627 | execution_results stringlengths 2 1.14M | query_type stringclasses 2 values | sql_category stringclasses 26 values | bio_category stringclasses 14 values |
|---|---|---|---|---|---|---|---|---|
Q11.65 | Q11 | Are there any VRK3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene VRK3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'VRK3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1366 | Q11 | Are there any UBAC2-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene UBAC2-AS1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'UBAC2-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.191 | Q11 | Are there any TRAPPC6A SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TRAPPC6A gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs10408847
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.89e-16; HEIDI: 2.8963e-23
• rs75858218
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.76e-09; HEIDI: 4.3429e-03
• rs12462040
• Cortex: Adjusted SMR multi-SNP P-value: 7.03e-07; HEIDI: 6.7784e-04
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRAPPC6A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503914', 'Gene': 'TRAPPC6A', 'topRSID': 'rs10408847', 'p_SMR_multi': 1.890037e-16, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.896294e-23}, {'UUID': 'NDD_SMR_genes_all_update_text_1397653', 'Gene': 'TRAPPC6A', 'topRSID': 'rs75858218', 'p_SMR_multi': 2.760943e-09, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.004342879}, {'UUID': 'NDD_SMR_genes_all_update_text_1108036', 'Gene': 'TRAPPC6A', 'topRSID': 'rs12462040', 'p_SMR_multi': 7.034371e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.0006778446}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1630 | Q11 | Are there any PPP1R32 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Tibial Nerve, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene PPP1R32 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'PPP1R32' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1395 | Q11 | Are there any AKR7A2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Multi Ancestry Whole Brain and Hypothalamus samples tested there are no SNPs within the gene AKR7A2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AKR7A2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1547 | Q11 | Are there any HMOX1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene HMOX1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'HMOX1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.346 | Q11 | Are there any GSTM5 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene GSTM5 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'GSTM5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.400 | Q11 | Are there any RP11-75L1.1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-75L1.1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-75L1.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1393 | Q11 | Are there any DND1P1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the DND1P1 gene has 5 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.42e-44; HEIDI: 8.5640e-12
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.27e-22; HEIDI: 6.7663e-09
• rs12373139
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 9.20e-33; HEIDI: 5.7418e-23
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.68e-30; HEIDI: 6.5741e-27
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 4.95e-28; HEIDI: 1.9527e-19
• rs1981997
• Cortex: Adjusted SMR multi-SNP P-value: 1.17e-18; HEIDI: 5.5703e-19
• Liver: Adjusted SMR multi-SNP P-value: 2.01e-18; HEIDI: 3.9152e-20
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 1.98e-15; HEIDI: 1.2228e-14
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 3.94e-15; HEIDI: 8.1405e-18
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 4.49e-15; HEIDI: 5.5655e-13
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 2.03e-14; HEIDI: 3.6292e-13
• Hypothalamus: Adjusted SMR multi-SNP P-value: 1.17e-13; HEIDI: 8.9697e-14
• Hippocampus: Adjusted SMR multi-SNP P-value: 2.99e-13; HEIDI: 9.8659e-13
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 3.91e-13; HEIDI: 3.6693e-11
• Cerebellum: Adjusted SMR multi-SNP P-value: 3.09e-12; HEIDI: 8.4170e-12
• Amygdala: Adjusted SMR multi-SNP P-value: 3.50e-11; HEIDI: 7.6437e-09
• Substantia nigra: Adjusted SMR multi-SNP P-value: 3.64e-10; HEIDI: 7.4607e-07
• rs11012
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.36e-18; HEIDI: 1.8465e-09
• rs1635291
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 1.17e-10; HEIDI: 1.0030e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'DND1P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041717', 'Gene': 'DND1P1', 'topRSID': 'rs169201', 'p_SMR_multi': 9.423973e-44, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.563959e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1375925', 'Gene': 'DND1P1', 'topRSID': 'rs12373139', 'p_SMR_multi': 9.1959e-33, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 5.741812e-23}, {'UUID': 'NDD_SMR_genes_all_update_text_1684931', 'Gene': 'DND1P1', 'topRSID': 'rs12373139', 'p_SMR_multi': 1.679239e-30, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.574053e-27}, {'UUID': 'NDD_SMR_genes_all_update_text_1336285', 'Gene': 'DND1P1', 'topRSID': 'rs12373139', 'p_SMR_multi': 4.947749e-28, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 1.952743e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_560847', 'Gene': 'DND1P1', 'topRSID': 'rs169201', 'p_SMR_multi': 2.2711060000000003e-22, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 6.766314e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1264978', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.168828e-18, 'Omic_tissue': 'Cortex', 'p_HEIDI': 5.570316e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_1478184', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.006353e-18, 'Omic_tissue': 'Liver', 'p_HEIDI': 3.915164e-20}, {'UUID': 'NDD_SMR_genes_all_update_text_1579417', 'Gene': 'DND1P1', 'topRSID': 'rs11012', 'p_SMR_multi': 6.355047e-18, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.846462e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1732391', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.984919e-15, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 1.222775e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_1596819', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.938411e-15, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 8.140454e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_1283698', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 4.486381e-15, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 5.565544e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1170870', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.025005e-14, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 3.629172e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1464414', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.167935e-13, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 8.96972e-14}, {'UUID': 'NDD_SMR_genes_all_update_text_1388479', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.988024e-13, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 9.865906e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1489534', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.907491e-13, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 3.669264e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1714151', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.090669e-12, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 8.416991e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1604710', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.495275e-11, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 7.643693e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1194212', 'Gene': 'DND1P1', 'topRSID': 'rs1635291', 'p_SMR_multi': 1.174317e-10, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 1.003004e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1452479', 'Gene': 'DND1P1', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.639455e-10, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 7.460653e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1876 | Q11 | Are there any RP11-641A6.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-641A6.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-641A6.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.199 | Q11 | Are there any ASB8 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Putamen Basal Ganglia, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ASB8 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ASB8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1173 | Q11 | Are there any MORN2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Tibial Nerve, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene MORN2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MORN2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.320 | Q11 | Are there any CRY1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Skeletal Muscle and Whole Blood samples tested there are no SNPs within the gene CRY1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CRY1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1002 | Q11 | Are there any MMP8 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene MMP8 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MMP8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.223 | Q11 | Are there any METTL7B SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene METTL7B that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'METTL7B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1220 | Q11 | Are there any AC079610.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC079610.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AC079610.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.103 | Q11 | Are there any ARGFX SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene ARGFX that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ARGFX' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1655 | Q11 | Are there any PDE4DIP SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene PDE4DIP that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'PDE4DIP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.949 | Q11 | Are there any ZDHHC2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene ZDHHC2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'ZDHHC2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1939 | Q11 | Are there any LRRC37A2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the LRRC37A2 gene has 6 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.86e-44; HEIDI: 1.4593e-11
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.45e-32; HEIDI: 4.9972e-10
• rs7225002
• Cortex: Adjusted SMR multi-SNP P-value: 6.07e-41; HEIDI: 2.6571e-31
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 3.00e-25; HEIDI: 3.7604e-19
• Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.20e-14; HEIDI: 1.0953e-09
• Hippocampus: Adjusted SMR multi-SNP P-value: 1.38e-13; HEIDI: 1.7831e-08
• rs1981997
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.83e-39; HEIDI: -9.9990e+03
• Cerebellum: Adjusted SMR multi-SNP P-value: 4.72e-22; HEIDI: 8.9844e-28
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 6.46e-22; HEIDI: 5.1288e-21
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 8.01e-20; HEIDI: 4.0290e-24
• Cortex: Adjusted SMR multi-SNP P-value: 1.15e-19; HEIDI: 2.0953e-21
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.27e-19; HEIDI: 7.3416e-22
• Hypothalamus: Adjusted SMR multi-SNP P-value: 1.54e-19; HEIDI: 2.6440e-21
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 2.48e-18; HEIDI: 3.9649e-20
• Hippocampus: Adjusted SMR multi-SNP P-value: 3.25e-18; HEIDI: 1.2749e-19
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 7.02e-18; HEIDI: 1.5264e-20
• Liver: Adjusted SMR multi-SNP P-value: 3.74e-14; HEIDI: 1.5646e-09
• Substantia nigra: Adjusted SMR multi-SNP P-value: 1.03e-13; HEIDI: 2.2587e-06
• rs12373139
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 8.61e-30; HEIDI: 6.4689e-15
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.85e-27; HEIDI: 1.0987e-15
• rs393152
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.27e-28; HEIDI: 4.3671e-27
• Amygdala: Adjusted SMR multi-SNP P-value: 1.65e-15; HEIDI: 2.3129e-17
• rs8070723
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 6.47e-17; HEIDI: 9.9615e-19
• Spinalcord: Adjusted SMR multi-SNP P-value: 2.16e-11; HEIDI: 1.7749e-07
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LRRC37A2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579429', 'Gene': 'LRRC37A2', 'topRSID': 'rs169201', 'p_SMR_multi': 3.8561219999999997e-44, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.459323e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1154400', 'Gene': 'LRRC37A2', 'topRSID': 'rs7225002', 'p_SMR_multi': 6.06628e-41, 'Omic_tissue': 'Cortex', 'p_HEIDI': 2.657098e-31}, {'UUID': 'NDD_SMR_genes_all_update_text_1444275', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.830322e-39, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1646050', 'Gene': 'LRRC37A2', 'topRSID': 'rs169201', 'p_SMR_multi': 1.448721e-32, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.997206e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1336298', 'Gene': 'LRRC37A2', 'topRSID': 'rs12373139', 'p_SMR_multi': 8.612767e-30, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 6.468901e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_22220', 'Gene': 'LRRC37A2', 'topRSID': 'rs393152', 'p_SMR_multi': 2.2734860000000003e-28, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 4.3670899999999995e-27}, {'UUID': 'NDD_SMR_genes_all_update_text_1684941', 'Gene': 'LRRC37A2', 'topRSID': 'rs12373139', 'p_SMR_multi': 2.849383e-27, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.09875e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_1375936', 'Gene': 'LRRC37A2', 'topRSID': 'rs7225002', 'p_SMR_multi': 2.998771e-25, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 3.760397e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_1714163', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 4.723072000000002e-22, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 8.98438e-28}, {'UUID': 'NDD_SMR_genes_all_update_text_1194223', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 6.455195e-22, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 5.128805e-21}, {'UUID': 'NDD_SMR_genes_all_update_text_1732402', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 8.013994e-20, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 4.028984e-24}, {'UUID': 'NDD_SMR_genes_all_update_text_1264989', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.153006e-19, 'Omic_tissue': 'Cortex', 'p_HEIDI': 2.095334e-21}, {'UUID': 'NDD_SMR_genes_all_update_text_1283710', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.265662e-19, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 7.341628000000002e-22}, {'UUID': 'NDD_SMR_genes_all_update_text_1464424', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.5374719999999998e-19, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 2.644028e-21}, {'UUID': 'NDD_SMR_genes_all_update_text_1170879', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.481395e-18, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 3.964873e-20}, {'UUID': 'NDD_SMR_genes_all_update_text_1388487', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.252101e-18, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 1.274896e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_1596829', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 7.019893e-18, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 1.526377e-20}, {'UUID': 'NDD_SMR_genes_all_update_text_1489544', 'Gene': 'LRRC37A2', 'topRSID': 'rs8070723', 'p_SMR_multi': 6.474394000000001e-17, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 9.961509e-19}, {'UUID': 'NDD_SMR_genes_all_update_text_1604719', 'Gene': 'LRRC37A2', 'topRSID': 'rs393152', 'p_SMR_multi': 1.654495e-15, 'Omic_tissue': 'Amygdala', 'p_HEIDI': 2.312915e-17}, {'UUID': 'NDD_SMR_genes_all_update_text_27915', 'Gene': 'LRRC37A2', 'topRSID': 'rs7225002', 'p_SMR_multi': 2.199261e-14, 'Omic_tissue': 'Basal Ganglia', 'p_HEIDI': 1.095297e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1478193', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 3.741471e-14, 'Omic_tissue': 'Liver', 'p_HEIDI': 1.564571e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1452486', 'Gene': 'LRRC37A2', 'topRSID': 'rs1981997', 'p_SMR_multi': 1.031055e-13, 'Omic_tissue': 'Substantia nigra', 'p_HEIDI': 2.258729e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_33474', 'Gene': 'LRRC37A2', 'topRSID': 'rs7225002', 'p_SMR_multi': 1.37808e-13, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 1.783082e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_30484', 'Gene': 'LRRC37A2', 'topRSID': 'rs8070723', 'p_SMR_multi': 2.162574e-11, 'Omic_tissue': 'Spinalcord', 'p_HEIDI': 1.774927e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1914 | Q11 | Are there any MIR3682 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene MIR3682 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'MIR3682' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1127 | Q11 | Are there any RP11-499O7.7 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene RP11-499O7.7 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-499O7.7' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1052 | Q11 | Are there any C1orf146 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum and Cortex samples tested there are no SNPs within the gene C1orf146 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C1orf146' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1538 | Q11 | Are there any GFOD1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cerebellar Hemisphere, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene GFOD1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'GFOD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.356 | Q11 | Are there any UBE2U SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Anterior Cingulate Cortex BA24 and Amygdala samples tested there are no SNPs within the gene UBE2U that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'UBE2U' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.603 | Q11 | Are there any SLC2A5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SLC2A5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SLC2A5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1559 | Q11 | Are there any PLEKHM1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the PLEKHM1 gene has 12 SNPs that are statistically significant in Parkinson's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs10451283
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 3.22e-13; HEIDI: -9.9990e+03
• rs62065453
• Cerebellum: Adjusted SMR multi-SNP P-value: 8.05e-13; HEIDI: -9.9990e+03
• rs1991556
• Cerebellum: Adjusted SMR multi-SNP P-value: 3.70e-12; HEIDI: -9.9990e+03
• rs12947718
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 7.76e-12; HEIDI: 3.5360e-02
• rs4383188
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 4.40e-11; HEIDI: -9.9990e+03
• rs10445367
• Cortex: Adjusted SMR multi-SNP P-value: 3.81e-09; HEIDI: 3.4718e-02
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 3.93e-09; HEIDI: 2.7722e-03
• rs79724577
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 5.90e-09; HEIDI: 1.5617e-02
• rs55663797
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.78e-08; HEIDI: 1.6742e-09
• rs55925547
• Cortex: Adjusted SMR multi-SNP P-value: 2.82e-08; HEIDI: 1.2079e-02
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 1.03e-06; HEIDI: 3.3940e-01
• rs79172804
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 2.22e-07; HEIDI: 4.6432e-02
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 1.19e-06; HEIDI: 5.3847e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PLEKHM1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1435913', 'Gene': 'PLEKHM1', 'topRSID': 'rs10451283', 'p_SMR_multi': 3.220666e-13, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_19645', 'Gene': 'PLEKHM1', 'topRSID': 'rs62065453', 'p_SMR_multi': 8.047881e-13, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1710340', 'Gene': 'PLEKHM1', 'topRSID': 'rs1991556', 'p_SMR_multi': 3.695806e-12, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1370536', 'Gene': 'PLEKHM1', 'topRSID': 'rs12947718', 'p_SMR_multi': 7.763854e-12, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.03535971}, {'UUID': 'NDD_SMR_genes_all_update_text_1191162', 'Gene': 'PLEKHM1', 'topRSID': 'rs4383188', 'p_SMR_multi': 4.397564e-11, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1262218', 'Gene': 'PLEKHM1', 'topRSID': 'rs10445367', 'p_SMR_multi': 3.805476e-09, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.03471772}, {'UUID': 'NDD_SMR_genes_all_update_text_1730057', 'Gene': 'PLEKHM1', 'topRSID': 'rs10445367', 'p_SMR_multi': 3.928019e-09, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 0.002772246}, {'UUID': 'NDD_SMR_genes_all_update_text_1242261', 'Gene': 'PLEKHM1', 'topRSID': 'rs79724577', 'p_SMR_multi': 5.896621e-09, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 0.01561697}, {'UUID': 'NDD_SMR_genes_all_update_text_1564775', 'Gene': 'PLEKHM1', 'topRSID': 'rs55663797', 'p_SMR_multi': 1.782097e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.674159e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1147252', 'Gene': 'PLEKHM1', 'topRSID': 'rs55925547', 'p_SMR_multi': 2.819249e-08, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.01207896}, {'UUID': 'NDD_SMR_genes_all_update_text_1281348', 'Gene': 'PLEKHM1', 'topRSID': 'rs79172804', 'p_SMR_multi': 2.221153e-07, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 0.04643205}, {'UUID': 'NDD_SMR_genes_all_update_text_1594918', 'Gene': 'PLEKHM1', 'topRSID': 'rs62065442', 'p_SMR_multi': 2.866553e-07, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.03026128}, {'UUID': 'NDD_SMR_genes_all_update_text_1640212', 'Gene': 'PLEKHM1', 'topRSID': 'rs113434679', 'p_SMR_multi': 7.172429e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.3130195}, {'UUID': 'NDD_SMR_genes_all_update_text_1488134', 'Gene': 'PLEKHM1', 'topRSID': 'rs55925547', 'p_SMR_multi': 1.027281e-06, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 0.3394045}, {'UUID': 'NDD_SMR_genes_all_update_text_1168830', 'Gene': 'PLEKHM1', 'topRSID': 'rs79172804', 'p_SMR_multi': 1.191544e-06, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': 0.05384652}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1350 | Q11 | Are there any POU5F1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the POU5F1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs1265098
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.17e-06; HEIDI: 1.4351e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'POU5F1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620801', 'Gene': 'POU5F1', 'topRSID': 'rs1265098', 'p_SMR_multi': 1.168562e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01435111}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1359 | Q11 | Are there any RP11-373D23.3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RP11-373D23.3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-373D23.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.947 | Q11 | Are there any TIMM22 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood, Putamen Basal Ganglia, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene TIMM22 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'TIMM22' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.348 | Q11 | Are there any CTD-3222D19.2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CTD-3222D19.2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTD-3222D19.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.606 | Q11 | Are there any GDE1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cerebellar Hemisphere, Prefrontal Cortex, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene GDE1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'GDE1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.719 | Q11 | Are there any OXCT1-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene OXCT1-AS1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'OXCT1-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.118 | Q11 | Are there any ANXA1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene ANXA1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'ANXA1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.617 | Q11 | Are there any METTL21A SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene METTL21A that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'METTL21A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1013 | Q11 | Are there any RP11-145M4.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-145M4.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-145M4.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1265 | Q11 | Are there any ZNF720 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cortex, Frontal Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene ZNF720 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ZNF720' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1489 | Q11 | Are there any PRDX3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex, Skeletal Muscle, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene PRDX3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'PRDX3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.489 | Q11 | Are there any RP11-137H2.4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the RP11-137H2.4 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs11185932
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.57e-09; HEIDI: 1.0265e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-137H2.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1497630', 'Gene': 'RP11-137H2.4', 'topRSID': 'rs11185932', 'p_SMR_multi': 2.56544e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1026472}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1711 | Q11 | Are there any RP5-827C21.6 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Cortex and Cerebellum samples tested there are no SNPs within the gene RP5-827C21.6 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP5-827C21.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.787 | Q11 | Are there any C1QTNF4 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the C1QTNF4 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs1317149
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.02e-06; HEIDI: 3.3812e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C1QTNF4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498219', 'Gene': 'C1QTNF4', 'topRSID': 'rs1317149', 'p_SMR_multi': 1.023534e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.000338117}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.881 | Q11 | Are there any SERPINE3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene SERPINE3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SERPINE3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1555 | Q11 | Are there any MEPCE SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the MEPCE gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs67471932
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.43e-07; HEIDI: 2.2632e-03
• rs6970806
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.14e-06; HEIDI: 9.2928e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'MEPCE' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495809', 'Gene': 'MEPCE', 'topRSID': 'rs67471932', 'p_SMR_multi': 1.430791e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002263153}, {'UUID': 'NDD_SMR_genes_all_update_text_1392631', 'Gene': 'MEPCE', 'topRSID': 'rs6970806', 'p_SMR_multi': 2.137433e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.09292833}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.567 | Q11 | Are there any CRKL SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CRKL that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CRKL' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.254 | Q11 | Are there any CR1L SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CR1L gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs4844385
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.72e-06; HEIDI: 2.1490e-08 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CR1L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_655845', 'Gene': 'CR1L', 'topRSID': 'rs4844385', 'p_SMR_multi': 2.715364e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.148959e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.242 | Q11 | Are there any GHRHR SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene GHRHR that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'GHRHR' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.176 | Q11 | Are there any RP11-823P9.3 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Tibial Nerve, Anterior Cingulate Cortex BA24, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RP11-823P9.3 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-823P9.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.824 | Q11 | Are there any CTD-2192J16.11 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene CTD-2192J16.11 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CTD-2192J16.11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.983 | Q11 | Are there any RP11-45A12.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-45A12.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-45A12.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1476 | Q11 | Are there any TREM2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TREM2 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs9394778
• Cortex: Adjusted SMR multi-SNP P-value: 6.31e-07; HEIDI: 7.0327e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TREM2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1109138', 'Gene': 'TREM2', 'topRSID': 'rs9394778', 'p_SMR_multi': 6.308333e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.7032683}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1262 | Q11 | Are there any EIF5 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene EIF5 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'EIF5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1280 | Q11 | Are there any RP11-430C7.5 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Tibial Nerve and Whole Blood samples tested there are no SNPs within the gene RP11-430C7.5 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-430C7.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.751 | Q11 | Are there any KLRC2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Spinalcord, Hippocampus, Whole Brain, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Whole Blood, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene KLRC2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KLRC2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.561 | Q11 | Are there any LCE1C SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain and Whole Blood samples tested there are no SNPs within the gene LCE1C that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LCE1C' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.81 | Q11 | Are there any RP11-45A12.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-45A12.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-45A12.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1042 | Q11 | Are there any STK39 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the STK39 gene has 5 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2390669
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.17e-07; HEIDI: 4.6493e-01
• rs13016703
• Whole Brain: Adjusted SMR multi-SNP P-value: 2.99e-07; HEIDI: 1.3663e-01
• rs13033661
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.41e-07; HEIDI: 8.8004e-02
• rs10930310
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.91e-06; HEIDI: 1.3668e-04
• rs17179976
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.79e-06; HEIDI: 6.7173e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'STK39' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_422838', 'Gene': 'STK39', 'topRSID': 'rs2390669', 'p_SMR_multi': 1.174594e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.4649286}, {'UUID': 'NDD_SMR_genes_all_update_text_422837', 'Gene': 'STK39', 'topRSID': 'rs13016703', 'p_SMR_multi': 2.989266e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.1366261}, {'UUID': 'NDD_SMR_genes_all_update_text_1019477', 'Gene': 'STK39', 'topRSID': 'rs13033661', 'p_SMR_multi': 4.406423e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.08800387}, {'UUID': 'NDD_SMR_genes_all_update_text_1554406', 'Gene': 'STK39', 'topRSID': 'rs10930310', 'p_SMR_multi': 1.908937e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0001366755}, {'UUID': 'NDD_SMR_genes_all_update_text_1019471', 'Gene': 'STK39', 'topRSID': 'rs17179976', 'p_SMR_multi': 2.794479e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.06717335}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1314 | Q11 | Are there any RAB29 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the RAB29 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs823118
• Cortex: Adjusted SMR multi-SNP P-value: 1.91e-06; HEIDI: 4.5812e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RAB29' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1142765', 'Gene': 'RAB29', 'topRSID': 'rs823118', 'p_SMR_multi': 1.914143e-06, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.004581236}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.33 | Q11 | Are there any IGKV2D-30 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene IGKV2D-30 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'IGKV2D-30' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1739 | Q11 | Are there any CTSZ SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CTSZ that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CTSZ' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.358 | Q11 | Are there any SNAI1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SNAI1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SNAI1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1077 | Q11 | Are there any DCHS2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene DCHS2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'DCHS2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1692 | Q11 | Are there any AC005682.8 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene AC005682.8 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'AC005682.8' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.127 | Q11 | Are there any ALDH18A1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cerebellar Hemisphere, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene ALDH18A1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ALDH18A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1031 | Q11 | Are there any TPSD1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene TPSD1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TPSD1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.399 | Q11 | Are there any RP11-763B22.9 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-763B22.9 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-763B22.9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.444 | Q11 | Are there any GAPDHP16 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellar Hemisphere samples tested there are no SNPs within the gene GAPDHP16 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'GAPDHP16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.166 | Q11 | Are there any SCARNA16 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene SCARNA16 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SCARNA16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.206 | Q11 | Are there any CTB-147C13.1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene CTB-147C13.1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTB-147C13.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1571 | Q11 | Are there any HNRNPM SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene HNRNPM that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'HNRNPM' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1641 | Q11 | Are there any RP11-252E2.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-252E2.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-252E2.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1565 | Q11 | Are there any RP11-120K24.3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Whole Blood and Whole Brain samples tested there are no SNPs within the gene RP11-120K24.3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-120K24.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.491 | Q11 | Are there any KLF16 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene KLF16 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'KLF16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1966 | Q11 | Are there any TTC3-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene TTC3-AS1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'TTC3-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1800 | Q11 | Are there any BCKDK SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the BCKDK gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs4889619
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.89e-08; HEIDI: 8.2320e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'BCKDK' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563816', 'Gene': 'BCKDK', 'topRSID': 'rs4889619', 'p_SMR_multi': 7.887199e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.008231964}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1330 | Q11 | Are there any NCCRP1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood and Cerebellar Hemisphere samples tested there are no SNPs within the gene NCCRP1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'NCCRP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.285 | Q11 | Are there any C7orf50 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene C7orf50 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'C7orf50' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1375 | Q11 | Are there any TRMU SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Whole Blood and Cerebellum samples tested there are no SNPs within the gene TRMU that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'TRMU' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.221 | Q11 | Are there any AL049758.2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene AL049758.2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'AL049758.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1931 | Q11 | Are there any DCAKD SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the DCAKD gene has 1 SNP that is statistically significant in Progressive supranuclear palsy:
• rs4413004
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.89e-08; HEIDI: 1.1770e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'DCAKD' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579401', 'Gene': 'DCAKD', 'topRSID': 'rs4413004', 'p_SMR_multi': 3.891266e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1176966}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.888 | Q11 | Are there any RP11-175P13.3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-175P13.3 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-175P13.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1623 | Q11 | Are there any RP4-576H24.5 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP4-576H24.5 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP4-576H24.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.701 | Q11 | Are there any VHLL SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene VHLL that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'VHLL' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.61 | Q11 | Are there any AC008984.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the AC008984.2 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs1761453
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.02e-06; HEIDI: 5.7705e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AC008984.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1504183', 'Gene': 'AC008984.2', 'topRSID': 'rs1761453', 'p_SMR_multi': 2.023069e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.05770473}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.843 | Q11 | Are there any C10orf107 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Frontal Cortex, Cerebellar Hemisphere, Cortex, Caudate Basal Ganglia, Tibial Nerve, Hippocampus, Substantia nigra, Hypothalamus, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene C10orf107 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'C10orf107' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1356 | Q11 | Are there any RP11-777B9.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-777B9.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-777B9.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.76 | Q11 | Are there any IAPP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene IAPP that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'IAPP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.165 | Q11 | Are there any FAM83F SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene FAM83F that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'FAM83F' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.576 | Q11 | Are there any RP11-67M1.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Tibial Nerve and Cerebellum samples tested there are no SNPs within the gene RP11-67M1.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-67M1.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.959 | Q11 | Are there any ZKSCAN1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ZKSCAN1 gene has 3 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4729568
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.57e-09; HEIDI: 1.9521e-07
• rs11771331
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.73e-09; HEIDI: 9.3196e-03
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.30e-07; HEIDI: 1.2810e-04
• rs4216
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 6.58e-08; HEIDI: 5.6684e-03
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.23e-06; HEIDI: 3.7046e-08
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZKSCAN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495787', 'Gene': 'ZKSCAN1', 'topRSID': 'rs4729568', 'p_SMR_multi': 2.568335e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.952063e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_585967', 'Gene': 'ZKSCAN1', 'topRSID': 'rs11771331', 'p_SMR_multi': 9.72543e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.009319552}, {'UUID': 'NDD_SMR_genes_all_update_text_1287862', 'Gene': 'ZKSCAN1', 'topRSID': 'rs4216', 'p_SMR_multi': 6.579727e-08, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 0.005668404}, {'UUID': 'NDD_SMR_genes_all_update_text_74022', 'Gene': 'ZKSCAN1', 'topRSID': 'rs11771331', 'p_SMR_multi': 1.301299e-07, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 0.0001281028}, {'UUID': 'NDD_SMR_genes_all_update_text_1392614', 'Gene': 'ZKSCAN1', 'topRSID': 'rs4216', 'p_SMR_multi': 2.233311e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 3.704643e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1540 | Q11 | Are there any SUGP1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene SUGP1 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SUGP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1046 | Q11 | Are there any TTC9 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene TTC9 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TTC9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1706 | Q11 | Are there any SENP1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene SENP1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SENP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.513 | Q11 | Are there any CPLX1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the CPLX1 gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs3088106
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.95e-07; HEIDI: 8.2543e-04 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CPLX1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_996235', 'Gene': 'CPLX1', 'topRSID': 'rs3088106', 'p_SMR_multi': 2.945018e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0008254259}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.46 | Q11 | Are there any THSD7B SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene THSD7B that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'THSD7B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.946 | Q11 | Are there any FAM107B SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain and Putamen Basal Ganglia samples tested there are no SNPs within the gene FAM107B that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'FAM107B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.366 | Q11 | Are there any RP11-795J1.1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-795J1.1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'RP11-795J1.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.540 | Q11 | Are there any HADHB SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Caudate Basal Ganglia, Skeletal Muscle, Multi Ancestry Whole Brain, Hypothalamus, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene HADHB that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'HADHB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.79 | Q11 | Are there any CRYGD SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene CRYGD that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CRYGD' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1917 | Q11 | Are there any PPP1R37 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the PPP1R37 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs10412988
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.19e-08; HEIDI: 3.8263e-10 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PPP1R37' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503912', 'Gene': 'PPP1R37', 'topRSID': 'rs10412988', 'p_SMR_multi': 1.185896e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 3.826285e-10}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1416 | Q11 | Are there any VAPA SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene VAPA that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `card-ai-389220.bio_sql_benchmark.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'VAPA' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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