uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
values | bio_category stringclasses 14
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|---|---|---|---|---|---|---|---|---|
Q11.1355 | Q11 | Are there any SENP6 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Cerebellum samples tested there are no SNPs within the gene SENP6 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SENP6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.226 | Q11 | Are there any RPS27L SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus and Anterior Cingulate Cortex BA24 samples tested there are no SNPs within the gene RPS27L that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RPS27L' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.148 | Q11 | Are there any CTB-83J4.1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CTB-83J4.1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTB-83J4.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1097 | Q11 | Are there any SVIP SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Cortex, Cerebellar Hemisphere, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene SVIP that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'SVIP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.379 | Q11 | Are there any RP11-56H16.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-56H16.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-56H16.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1422 | Q11 | Are there any SLC25A1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SLC25A1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'SLC25A1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1152 | Q11 | Are there any RP1-293L8.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Prefrontal Cortex samples tested there are no SNPs within the gene RP1-293L8.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP1-293L8.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1828 | Q11 | Are there any CKM SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the CKM gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs386569
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.61e-08; HEIDI: 2.1922e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CKM' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503918', 'Gene': 'CKM', 'topRSID': 'rs386569', 'p_SMR_multi': 2.608329e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.021922}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1496 | Q11 | Are there any PCGF3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the PCGF3 gene has 3 SNPs that are statistically significant in Parkinson's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs28743077
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.41e-09; HEIDI: 3.5148e-04
• rs11940788
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.30e-07; HEIDI: 1.3810e-02
• rs3775142
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.03e-06; HEIDI: 2.3926e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'PCGF3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_996184', 'Gene': 'PCGF3', 'topRSID': 'rs28743077', 'p_SMR_multi': 3.407907e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.000351479}, {'UUID': 'NDD_SMR_genes_all_update_text_996183', 'Gene': 'PCGF3', 'topRSID': 'rs11940788', 'p_SMR_multi': 4.304558e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01380985}, {'UUID': 'NDD_SMR_genes_all_update_text_1555634', 'Gene': 'PCGF3', 'topRSID': 'rs3775142', 'p_SMR_multi': 1.03112e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02392648}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1602 | Q11 | Are there any RP11-57C13.3 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-57C13.3 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-57C13.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1759 | Q11 | Are there any ZNF10 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood, Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene ZNF10 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'ZNF10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.10 | Q11 | Are there any CAMSAP1L1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene CAMSAP1L1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'CAMSAP1L1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.455 | Q11 | Are there any NDFIP1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Skeletal Muscle, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene NDFIP1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'NDFIP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.715 | Q11 | Are there any CHST15 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Tibial Nerve, Multi Ancestry Whole Brain and Liver samples tested there are no SNPs within the gene CHST15 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CHST15' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.258 | Q11 | Are there any ZSCAN18 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Tibial Nerve, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene ZSCAN18 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ZSCAN18' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.889 | Q11 | Are there any ARHGAP27 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the ARHGAP27 gene has 4 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs11012
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.18e-40; HEIDI: 2.7612e-07
• Whole Brain: Adjusted SMR multi-SNP P-value: 9.28e-28; HEIDI: -9.9990e+03
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 9.17e-15; HEIDI: 1.9863e-21
• rs169201
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.03e-13; HEIDI: 2.0851e-03
• rs1981997
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 2.59e-13; HEIDI: 1.6832e-11
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 4.80e-08; HEIDI: 4.7380e-06
• rs1230103
• Cortex: Adjusted SMR multi-SNP P-value: 1.52e-09; HEIDI: 4.0822e-05
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'ARHGAP27' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1041709', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 3.175631e-40, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.761191e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1041713', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 1.378348e-39, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 8.450584e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1041708', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 7.2253840000000005e-28, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.190862e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_560834', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 9.282341e-28, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1041710', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 9.844243e-21, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.44795e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_560838', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 1.788484e-17, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560840', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 1.26046e-16, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560839', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 1.971352e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560835', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 7.442074e-15, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 1.260381e-15}, {'UUID': 'NDD_SMR_genes_all_update_text_1444267', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 9.167847e-15, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.986258e-21}, {'UUID': 'NDD_SMR_genes_all_update_text_1041706', 'Gene': 'ARHGAP27', 'topRSID': 'rs169201', 'p_SMR_multi': 1.028577e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.002085073}, {'UUID': 'NDD_SMR_genes_all_update_text_1041707', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 1.359097e-13, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.07969932}, {'UUID': 'NDD_SMR_genes_all_update_text_1732388', 'Gene': 'ARHGAP27', 'topRSID': 'rs1981997', 'p_SMR_multi': 2.587633e-13, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 1.683187e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_560837', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 2.673637e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560841', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 3.08796e-13, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1579412', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 1.305912e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.01603211}, {'UUID': 'NDD_SMR_genes_all_update_text_560836', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 5.243165e-12, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 4.456056e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1041712', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 8.748855e-12, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3462195}, {'UUID': 'NDD_SMR_genes_all_update_text_560843', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 7.455937e-11, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_560842', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 1.444009e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1154392', 'Gene': 'ARHGAP27', 'topRSID': 'rs1230103', 'p_SMR_multi': 1.523917e-09, 'Omic_tissue': 'Cortex', 'p_HEIDI': 4.082213e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1041711', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 1.913055e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2092193}, {'UUID': 'NDD_SMR_genes_all_update_text_1283695', 'Gene': 'ARHGAP27', 'topRSID': 'rs1981997', 'p_SMR_multi': 4.799834e-08, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 4.737999e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1041705', 'Gene': 'ARHGAP27', 'topRSID': 'rs11012', 'p_SMR_multi': 2.348543e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.5244976}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.395 | Q11 | Are there any RP11-580I1.2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-580I1.2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-580I1.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.916 | Q11 | Are there any CTD-2587M2.1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Cortex, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Liver, Whole Blood, Putamen Basal Ganglia, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene CTD-2587M2.1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CTD-2587M2.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.932 | Q11 | Are there any RNF170 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Multi Ancestry Whole Brain and Whole Blood samples tested there are no SNPs within the gene RNF170 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RNF170' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1704 | Q11 | Are there any VPS41 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Cortex, Cerebellar Hemisphere, Tibial Nerve, Multi Ancestry Whole Brain, Whole Blood, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene VPS41 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'VPS41' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1231 | Q11 | Are there any CTB-39G8.3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the CTB-39G8.3 gene has 1 SNP that is statistically significant in Progressive supranuclear palsy:
• rs1230103
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.32e-06; HEIDI: -9.9990e+03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTB-39G8.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1684927', 'Gene': 'CTB-39G8.3', 'topRSID': 'rs1230103', 'p_SMR_multi': 1.318334e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.466 | Q11 | Are there any MMRN1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | Yes, the MMRN1 gene has 1 SNP that is statistically significant in Lewy Body Dementia:
• rs1372525
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.26e-08; HEIDI: 5.9547e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MMRN1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1540411', 'Gene': 'MMRN1', 'topRSID': 'rs1372525', 'p_SMR_multi': 2.257256e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.005954692}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1967 | Q11 | Are there any IPO11 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene IPO11 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'IPO11' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1178 | Q11 | Are there any C7orf43 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the C7orf43 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs6975031
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.99e-09; HEIDI: 4.0038e-07 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C7orf43' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495797', 'Gene': 'C7orf43', 'topRSID': 'rs6975031', 'p_SMR_multi': 1.991609e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.003791e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.967 | Q11 | Are there any PILRB SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the PILRB gene has 6 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs6955367
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.43e-16; HEIDI: 5.1321e-05
• rs76798830
• Cortex: Adjusted SMR multi-SNP P-value: 2.23e-10; HEIDI: 1.6901e-03
• rs2897358
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 1.21e-09; HEIDI: 6.5833e-02
• rs7799901
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.83e-09; HEIDI: 1.6475e-01
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.26e-06; HEIDI: 2.0838e-01
• rs6975660
• Prefrontal Cortex: Adjusted SMR multi-SNP P-value: 1.82e-07; HEIDI: 9.6624e-05
• rs112622797
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.46e-07; HEIDI: 1.7239e-03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PILRB' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495806', 'Gene': 'PILRB', 'topRSID': 'rs6955367', 'p_SMR_multi': 8.429652e-16, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.132122e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1105975', 'Gene': 'PILRB', 'topRSID': 'rs76798830', 'p_SMR_multi': 2.227993e-10, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.001690066}, {'UUID': 'NDD_SMR_genes_all_update_text_1392628', 'Gene': 'PILRB', 'topRSID': 'rs2897358', 'p_SMR_multi': 1.205748e-09, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 0.06583308}, {'UUID': 'NDD_SMR_genes_all_update_text_585990', 'Gene': 'PILRB', 'topRSID': 'rs7799901', 'p_SMR_multi': 2.834641e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.1647482}, {'UUID': 'NDD_SMR_genes_all_update_text_1198853', 'Gene': 'PILRB', 'topRSID': 'rs6975660', 'p_SMR_multi': 1.815993e-07, 'Omic_tissue': 'Prefrontal Cortex', 'p_HEIDI': 9.662354e-05}, {'UUID': 'NDD_SMR_genes_all_update_text_1649656', 'Gene': 'PILRB', 'topRSID': 'rs112622797', 'p_SMR_multi': 9.457238e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001723871}, {'UUID': 'NDD_SMR_genes_all_update_text_1340321', 'Gene': 'PILRB', 'topRSID': 'rs7799901', 'p_SMR_multi': 1.260226e-06, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 0.2083771}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.507 | Q11 | Are there any RASAL3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood and Skeletal Muscle samples tested there are no SNPs within the gene RASAL3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RASAL3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.746 | Q11 | Are there any TNS4 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene TNS4 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'TNS4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1851 | Q11 | Are there any RP11-67P15.1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-67P15.1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-67P15.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.875 | Q11 | Are there any IRAK2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene IRAK2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'IRAK2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.738 | Q11 | Are there any C3orf66 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene C3orf66 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'C3orf66' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.545 | Q11 | Are there any RP11-31F19.1 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-31F19.1 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'RP11-31F19.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1211 | Q11 | Are there any KRT81 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Frontal Cortex, Prefrontal Cortex, Hippocampus, Substantia nigra, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene KRT81 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'KRT81' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.704 | Q11 | Are there any AC073869.2 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Frontal Cortex, Prefrontal Cortex, Cortex, Caudate Basal Ganglia, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene AC073869.2 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC073869.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1394 | Q11 | Are there any RP11-114H24.5 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RP11-114H24.5 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-114H24.5' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1783 | Q11 | Are there any RP11-448G15.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene RP11-448G15.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-448G15.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1155 | Q11 | Are there any LDLRAP1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Basal Ganglia, Hippocampus, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Multi Ancestry Whole Brain, Substantia nigra, Putamen Basal Ganglia, Amygdala and Nucleus Accumbens Basal samples tested there are no SNPs within the gene LDLRAP1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'LDLRAP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1040 | Q11 | Are there any PSORS1C1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the PSORS1C1 gene has 11 SNPs that are statistically significant in Alzheimer's Disease. Here are the top 10 SNPs along with their adjusted SMR p-values:
• rs9501055
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.49e-08; HEIDI: 4.8590e-03
• rs3909111
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.91e-07; HEIDI: 1.2033e-02
• rs3131003
• Whole Blood: Adjusted SMR multi-SNP P-value: 4.59e-07; HEIDI: 2.1699e-08
• rs6911408
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.35e-07; HEIDI: 3.2366e-04
• rs28732097
• Whole Blood: Adjusted SMR multi-SNP P-value: 7.27e-07; HEIDI: 2.6124e-02
• rs141943201
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.09e-07; HEIDI: 3.0818e-01
• rs3130979
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.38e-06; HEIDI: 4.9531e-02
• rs707913
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.50e-06; HEIDI: 2.6302e-01
• rs1265093
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.01e-06; HEIDI: 7.9340e-04
• rs3094197
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.26e-06; HEIDI: 3.5014e-02
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'PSORS1C1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620729', 'Gene': 'PSORS1C1', 'topRSID': 'rs9501055', 'p_SMR_multi': 5.485384e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.004858996}, {'UUID': 'NDD_SMR_genes_all_update_text_620724', 'Gene': 'PSORS1C1', 'topRSID': 'rs3909111', 'p_SMR_multi': 1.905324e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0120331}, {'UUID': 'NDD_SMR_genes_all_update_text_620712', 'Gene': 'PSORS1C1', 'topRSID': 'rs3131003', 'p_SMR_multi': 4.58781e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 2.169864e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_620719', 'Gene': 'PSORS1C1', 'topRSID': 'rs6911408', 'p_SMR_multi': 5.354445e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0003236574}, {'UUID': 'NDD_SMR_genes_all_update_text_620731', 'Gene': 'PSORS1C1', 'topRSID': 'rs28732097', 'p_SMR_multi': 7.271994e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02612357}, {'UUID': 'NDD_SMR_genes_all_update_text_620722', 'Gene': 'PSORS1C1', 'topRSID': 'rs141943201', 'p_SMR_multi': 8.08675e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.3081788}, {'UUID': 'NDD_SMR_genes_all_update_text_620695', 'Gene': 'PSORS1C1', 'topRSID': 'rs3130979', 'p_SMR_multi': 1.375028e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.04953092}, {'UUID': 'NDD_SMR_genes_all_update_text_620721', 'Gene': 'PSORS1C1', 'topRSID': 'rs707913', 'p_SMR_multi': 1.496852e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2630174}, {'UUID': 'NDD_SMR_genes_all_update_text_620740', 'Gene': 'PSORS1C1', 'topRSID': 'rs1265093', 'p_SMR_multi': 2.012412e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0007933961}, {'UUID': 'NDD_SMR_genes_all_update_text_620709', 'Gene': 'PSORS1C1', 'topRSID': 'rs3094197', 'p_SMR_multi': 2.258954e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03501374}, {'UUID': 'NDD_SMR_genes_all_update_text_620713', 'Gene': 'PSORS1C1', 'topRSID': 'rs3131003', 'p_SMR_multi': 2.271991e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.251638e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_620708', 'Gene': 'PSORS1C1', 'topRSID': 'rs1042148', 'p_SMR_multi': 2.345112e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0346833}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.378 | Q11 | Are there any RP11-565A3.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene RP11-565A3.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-565A3.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.674 | Q11 | Are there any RP11-77H9.6 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-77H9.6 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP11-77H9.6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1527 | Q11 | Are there any KLF16 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the KLF16 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2289286
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.87e-07; HEIDI: 1.9736e-03
• rs12977787
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 2.33e-06; HEIDI: 2.2131e-08
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'KLF16' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_634435', 'Gene': 'KLF16', 'topRSID': 'rs2289286', 'p_SMR_multi': 1.865688e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.001973643}, {'UUID': 'NDD_SMR_genes_all_update_text_1397200', 'Gene': 'KLF16', 'topRSID': 'rs12977787', 'p_SMR_multi': 2.33404e-06, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 2.21306e-08}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.362 | Q11 | Are there any SLC49A4 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene SLC49A4 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SLC49A4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.976 | Q11 | Are there any WIPF1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Basal Ganglia, Hippocampus, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Multi Ancestry Whole Brain, Substantia nigra, Whole Blood, Putamen Basal Ganglia, Amygdala, Whole Brain, Cerebellum and Nucleus Accumbens Basal samples tested there are no SNPs within the gene WIPF1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'WIPF1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.790 | Q11 | Are there any SEPSECS SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SEPSECS that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'SEPSECS' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.742 | Q11 | Are there any ZNF616 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cortex and Whole Blood samples tested there are no SNPs within the gene ZNF616 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ZNF616' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1044 | Q11 | Are there any COPS6 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the COPS6 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs1130958
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.08e-09; HEIDI: 2.1648e-01 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'COPS6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1495790', 'Gene': 'COPS6', 'topRSID': 'rs1130958', 'p_SMR_multi': 2.084808e-09, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.2164842}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.979 | Q11 | Are there any TRIM35 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TRIM35 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs7830415
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.29e-07; HEIDI: 4.3438e-07 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRIM35' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1496304', 'Gene': 'TRIM35', 'topRSID': 'rs7830415', 'p_SMR_multi': 2.29082e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 4.343769e-07}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1526 | Q11 | Are there any MGC72080 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene MGC72080 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MGC72080' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1488 | Q11 | Are there any TEX44 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene TEX44 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TEX44' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1525 | Q11 | Are there any CTD-2058B24.2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene CTD-2058B24.2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'CTD-2058B24.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1492 | Q11 | Are there any C21orf63 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene C21orf63 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'C21orf63' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1694 | Q11 | Are there any SSTR1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SSTR1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SSTR1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1716 | Q11 | Are there any IFNL3P1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene IFNL3P1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'IFNL3P1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1246 | Q11 | Are there any AP000439.2 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AP000439.2 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'AP000439.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.892 | Q11 | Are there any AC004538.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain, Prefrontal Cortex and Tibial Nerve samples tested there are no SNPs within the gene AC004538.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AC004538.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.82 | Q11 | Are there any DPCR1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the DPCR1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs2233980
• Whole Blood: Adjusted SMR multi-SNP P-value: 5.38e-08; HEIDI: 3.5616e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'DPCR1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_620628', 'Gene': 'DPCR1', 'topRSID': 'rs2233980', 'p_SMR_multi': 5.375279e-08, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03561558}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1182 | Q11 | Are there any NSFP1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the NSFP1 gene has 2 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs17692129
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.51e-24; HEIDI: 5.4446e-16
• Putamen Basal Ganglia: Adjusted SMR multi-SNP P-value: 1.45e-11; HEIDI: 3.9510e-01
• rs4792831
• Whole Blood: Adjusted SMR multi-SNP P-value: 8.73e-17; HEIDI: 6.1159e-25
• Skeletal Muscle: Adjusted SMR multi-SNP P-value: 1.68e-16; HEIDI: 7.7676e-27
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 4.81e-13; HEIDI: 4.5682e-18
• Nucleus Accumbens Basal: Adjusted SMR multi-SNP P-value: 6.61e-12; HEIDI: 8.9767e-09
• Cortex: Adjusted SMR multi-SNP P-value: 7.95e-12; HEIDI: 1.7010e-09
• Cerebellum: Adjusted SMR multi-SNP P-value: 1.22e-11; HEIDI: 5.2168e-10
• Cerebellar Hemisphere: Adjusted SMR multi-SNP P-value: 4.48e-11; HEIDI: 3.6559e-11
• Caudate Basal Ganglia: Adjusted SMR multi-SNP P-value: 5.32e-11; HEIDI: 1.0555e-07
• Liver: Adjusted SMR multi-SNP P-value: 2.17e-10; HEIDI: 9.6466e-12
• Anterior Cingulate Cortex BA24: Adjusted SMR multi-SNP P-value: 4.31e-10; HEIDI: 3.0956e-10
• Amygdala: Adjusted SMR multi-SNP P-value: 4.71e-10; HEIDI: -9.9990e+03
• Frontal Cortex: Adjusted SMR multi-SNP P-value: 1.11e-09; HEIDI: -9.9990e+03
• Hypothalamus: Adjusted SMR multi-SNP P-value: 5.12e-09; HEIDI: 7.3946e-13
• Hippocampus: Adjusted SMR multi-SNP P-value: 1.42e-08; HEIDI: 9.9954e-11
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'NSFP1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579428', 'Gene': 'NSFP1', 'topRSID': 'rs17692129', 'p_SMR_multi': 6.512217e-24, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.444598e-16}, {'UUID': 'NDD_SMR_genes_all_update_text_1684940', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 8.727098000000001e-17, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 6.115947e-25}, {'UUID': 'NDD_SMR_genes_all_update_text_1375935', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 1.681578e-16, 'Omic_tissue': 'Skeletal Muscle', 'p_HEIDI': 7.767569999999999e-27}, {'UUID': 'NDD_SMR_genes_all_update_text_1336297', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 4.811439e-13, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 4.568217e-18}, {'UUID': 'NDD_SMR_genes_all_update_text_1732401', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 6.608576e-12, 'Omic_tissue': 'Nucleus Accumbens Basal', 'p_HEIDI': 8.976722e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1264988', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 7.947629e-12, 'Omic_tissue': 'Cortex', 'p_HEIDI': 1.700974e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1714162', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 1.218244e-11, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 5.216785e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1596828', 'Gene': 'NSFP1', 'topRSID': 'rs17692129', 'p_SMR_multi': 1.446027e-11, 'Omic_tissue': 'Putamen Basal Ganglia', 'p_HEIDI': 0.3950962}, {'UUID': 'NDD_SMR_genes_all_update_text_1194222', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 4.481296e-11, 'Omic_tissue': 'Cerebellar Hemisphere', 'p_HEIDI': 3.655884e-11}, {'UUID': 'NDD_SMR_genes_all_update_text_1283709', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 5.322685e-11, 'Omic_tissue': 'Caudate Basal Ganglia', 'p_HEIDI': 1.055477e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1478192', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 2.170348e-10, 'Omic_tissue': 'Liver', 'p_HEIDI': 9.646594e-12}, {'UUID': 'NDD_SMR_genes_all_update_text_1489543', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 4.313718e-10, 'Omic_tissue': 'Anterior Cingulate Cortex BA24', 'p_HEIDI': 3.095568e-10}, {'UUID': 'NDD_SMR_genes_all_update_text_1604718', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 4.706001e-10, 'Omic_tissue': 'Amygdala', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1170878', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 1.110217e-09, 'Omic_tissue': 'Frontal Cortex', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1464423', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 5.118727e-09, 'Omic_tissue': 'Hypothalamus', 'p_HEIDI': 7.394618e-13}, {'UUID': 'NDD_SMR_genes_all_update_text_1388486', 'Gene': 'NSFP1', 'topRSID': 'rs4792831', 'p_SMR_multi': 1.422993e-08, 'Omic_tissue': 'Hippocampus', 'p_HEIDI': 9.995444e-11}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.821 | Q11 | Are there any CA12 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene CA12 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'CA12' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1283 | Q11 | Are there any RP11-64D22.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex, Tibial Nerve and Liver samples tested there are no SNPs within the gene RP11-64D22.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-64D22.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.678 | Q11 | Are there any AC009107.1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene AC009107.1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC009107.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1533 | Q11 | Are there any ERCC2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ERCC2 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs171140
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.75e-06; HEIDI: 3.9685e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ERCC2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503920', 'Gene': 'ERCC2', 'topRSID': 'rs171140', 'p_SMR_multi': 1.751872e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03968516}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.59 | Q11 | Are there any AC046143.3 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC046143.3 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'AC046143.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.136 | Q11 | Are there any STYXL1 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain, Hypothalamus, Liver, Anterior Cingulate Cortex BA24, Putamen Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene STYXL1 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'STYXL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1150 | Q11 | Are there any ATP8B3 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the ATP8B3 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs7250872
• Whole Blood: Adjusted SMR multi-SNP P-value: 9.57e-07; HEIDI: 5.0227e-03 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'ATP8B3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1503153', 'Gene': 'ATP8B3', 'topRSID': 'rs7250872', 'p_SMR_multi': 9.567693e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.005022678}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.942 | Q11 | Are there any WNT3 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | Yes, the WNT3 gene has 5 SNPs that are statistically significant in Progressive supranuclear palsy. Here are the SNPs along with their adjusted SMR p-values:
• rs2074404
• Whole Blood: Adjusted SMR multi-SNP P-value: 6.75e-20; HEIDI: 1.3082e-04
• rs8069437
• Cortex: Adjusted SMR multi-SNP P-value: 9.26e-18; HEIDI: 1.2071e-08
• Multi Ancestry Whole Brain: Adjusted SMR multi-SNP P-value: 4.41e-13; HEIDI: 5.2477e-09
• rs415430
• Tibial Nerve: Adjusted SMR multi-SNP P-value: 1.53e-12; HEIDI: 5.4107e-06
• rs12952746
• Whole Brain: Adjusted SMR multi-SNP P-value: 1.31e-10; HEIDI: 8.3832e-07
• rs8074816
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.63e-06; HEIDI: -9.9990e+03
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'WNT3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1579433', 'Gene': 'WNT3', 'topRSID': 'rs2074404', 'p_SMR_multi': 6.747848e-20, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.000130815}, {'UUID': 'NDD_SMR_genes_all_update_text_1154402', 'Gene': 'WNT3', 'topRSID': 'rs8069437', 'p_SMR_multi': 9.262221e-18, 'Omic_tissue': 'Cortex', 'p_HEIDI': 1.20707e-08}, {'UUID': 'NDD_SMR_genes_all_update_text_1444278', 'Gene': 'WNT3', 'topRSID': 'rs8069437', 'p_SMR_multi': 4.410459e-13, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 5.247729e-09}, {'UUID': 'NDD_SMR_genes_all_update_text_1336301', 'Gene': 'WNT3', 'topRSID': 'rs415430', 'p_SMR_multi': 1.531814e-12, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 5.410745e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1646053', 'Gene': 'WNT3', 'topRSID': 'rs12952746', 'p_SMR_multi': 1.306315e-10, 'Omic_tissue': 'Whole Brain', 'p_HEIDI': 8.383191e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_1041775', 'Gene': 'WNT3', 'topRSID': 'rs8074816', 'p_SMR_multi': 2.627101e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': -9999.0}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1685 | Q11 | Are there any RP11-58A11.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene RP11-58A11.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-58A11.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.830 | Q11 | Are there any C2orf73 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Cortex samples tested there are no SNPs within the gene C2orf73 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'C2orf73' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1224 | Q11 | Are there any HTR1B SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex and Tibial Nerve samples tested there are no SNPs within the gene HTR1B that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'HTR1B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.510 | Q11 | Are there any C19orf6 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the C19orf6 gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs4807395
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.49e-06; HEIDI: 3.9088e-04
• rs7251792
• Whole Blood: Adjusted SMR multi-SNP P-value: 1.60e-06; HEIDI: 1.7720e-06
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'C19orf6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_634274', 'Gene': 'C19orf6', 'topRSID': 'rs4807395', 'p_SMR_multi': 1.492903e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0003908802}, {'UUID': 'NDD_SMR_genes_all_update_text_634273', 'Gene': 'C19orf6', 'topRSID': 'rs7251792', 'p_SMR_multi': 1.597138e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 1.771956e-06}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1776 | Q11 | Are there any AC004471.9 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene AC004471.9 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'AC004471.9' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.351 | Q11 | Are there any RP11-61J19.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene RP11-61J19.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-61J19.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.392 | Q11 | Are there any OR8B10P SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Whole Brain and Prefrontal Cortex samples tested there are no SNPs within the gene OR8B10P that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'OR8B10P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1033 | Q11 | Are there any CYSLTR2 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene CYSLTR2 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'CYSLTR2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.901 | Q11 | Are there any RP11-597M17.2 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Tibial Nerve samples tested there are no SNPs within the gene RP11-597M17.2 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RP11-597M17.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.835 | Q11 | Are there any RN7SL538P SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Caudate Basal Ganglia and Nucleus Accumbens Basal samples tested there are no SNPs within the gene RN7SL538P that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'RN7SL538P' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1894 | Q11 | Are there any TBX6 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the TBX6 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs3809627
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.82e-07; HEIDI: 5.0366e-06 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TBX6' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1501443', 'Gene': 'TBX6', 'topRSID': 'rs3809627', 'p_SMR_multi': 2.822436e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 5.036562e-06}, {'UUID': 'NDD_SMR_genes_all_update_text_1111647', 'Gene': 'TBX6', 'topRSID': 'rs3809627', 'p_SMR_multi': 4.169908e-07, 'Omic_tissue': 'Cortex', 'p_HEIDI': 0.0001585194}, {'UUID': 'NDD_SMR_genes_all_update_text_1396163', 'Gene': 'TBX6', 'topRSID': 'rs3809627', 'p_SMR_multi': 4.656974e-07, 'Omic_tissue': 'Multi Ancestry Whole Brain', 'p_HEIDI': 1.912084e-07}, {'UUID': 'NDD_SMR_genes_all_update_text_577435', 'Gene': 'TBX6', 'topRSID': 'rs3809627', 'p_SMR_multi': 1.122228e-06, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.0008741498}, {'UUID': 'NDD_SMR_genes_all_update_text_1291220', 'Gene': 'TBX6', 'topRSID': 'rs3809627', 'p_SMR_multi': 1.430013e-06, 'Omic_tissue': 'Tibial Nerve', 'p_HEIDI': 8.78868e-05}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.481 | Q11 | Are there any SPPL2C SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the SPPL2C gene has 2 SNPs that are statistically significant in Alzheimer's Disease. Here are the SNPs along with their adjusted SMR p-values:
• rs2532233
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.37e-06; HEIDI: -9.9990e+03
• rs17573607
• Cerebellum: Adjusted SMR multi-SNP P-value: 2.71e-06; HEIDI: 9.2014e-01
| SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'SPPL2C' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_2656', 'Gene': 'SPPL2C', 'topRSID': 'rs2532233', 'p_SMR_multi': 2.367296e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': -9999.0}, {'UUID': 'NDD_SMR_genes_all_update_text_1690044', 'Gene': 'SPPL2C', 'topRSID': 'rs17573607', 'p_SMR_multi': 2.714257e-06, 'Omic_tissue': 'Cerebellum', 'p_HEIDI': 0.9201365}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1472 | Q11 | Are there any TMEM151A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood samples tested there are no SNPs within the gene TMEM151A that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'TMEM151A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1887 | Q11 | Are there any TATDN3 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Cerebellar Hemisphere, Prefrontal Cortex, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene TATDN3 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'TATDN3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1398 | Q11 | Are there any RP11-56P9.10 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-56P9.10 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'RP11-56P9.10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.659 | Q11 | Are there any AP001257.1 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the AP001257.1 gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs620368
• Whole Blood: Adjusted SMR multi-SNP P-value: 3.20e-10; HEIDI: 3.3203e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'AP001257.1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1498261', 'Gene': 'AP001257.1', 'topRSID': 'rs620368', 'p_SMR_multi': 3.201054e-10, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.03320265}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.175 | Q11 | Are there any MAST2 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MAST2 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'MAST2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1159 | Q11 | Are there any MYO1B SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Prefrontal Cortex and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene MYO1B that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'MYO1B' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.39 | Q11 | Are there any CTD-2530N21.4 SNPs that have a statistically significant adjusted SMR p-value in association with Lewy Body Dementia and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Tibial Nerve samples tested there are no SNPs within the gene CTD-2530N21.4 that are significantly associated with Lewy Body Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'LBD' AND Gene = 'CTD-2530N21.4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.720 | Q11 | Are there any AGL SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Cortex, Caudate Basal Ganglia, Tibial Nerve, Multi Ancestry Whole Brain and Nucleus Accumbens Basal samples tested there are no SNPs within the gene AGL that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'AGL' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.93 | Q11 | Are there any GCLC SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Whole Blood, Cortex, Prefrontal Cortex, Tibial Nerve, Hippocampus, Multi Ancestry Whole Brain and Whole Brain samples tested there are no SNPs within the gene GCLC that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'GCLC' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1937 | Q11 | Are there any MTTP SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain and Cortex samples tested there are no SNPs within the gene MTTP that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'MTTP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1215 | Q11 | Are there any ITGAX SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | Yes, the ITGAX gene has 1 SNP that is statistically significant in Parkinson's Disease:
• rs11574631
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.59e-07; HEIDI: 8.3626e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ITGAX' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1563822', 'Gene': 'ITGAX', 'topRSID': 'rs11574631', 'p_SMR_multi': 2.59174e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.08362627}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.882 | Q11 | Are there any VPS36 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Cortex, Prefrontal Cortex, Skeletal Muscle, Multi Ancestry Whole Brain, Whole Blood and Whole Brain samples tested there are no SNPs within the gene VPS36 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'VPS36' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1353 | Q11 | Are there any SREBF2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Multi Ancestry Whole Brain samples tested there are no SNPs within the gene SREBF2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SREBF2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1891 | Q11 | Are there any SMC5-AS1 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood and Prefrontal Cortex samples tested there are no SNPs within the gene SMC5-AS1 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'SMC5-AS1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1102 | Q11 | Are there any RP11-499F3.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain samples tested there are no SNPs within the gene RP11-499F3.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RP11-499F3.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1165 | Q11 | Are there any RP4-610C12.3 SNPs that have a statistically significant adjusted SMR p-value in association with Frontotemporal Dementia and what tissues are they significant in? | No, based on the Prefrontal Cortex, Whole Blood and Whole Brain samples tested there are no SNPs within the gene RP4-610C12.3 that are significantly associated with Frontotemporal Dementia. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'FTD' AND Gene = 'RP4-610C12.3' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1365 | Q11 | Are there any CTD-2005H7.2 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Blood, Tibial Nerve and Skeletal Muscle samples tested there are no SNPs within the gene CTD-2005H7.2 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'CTD-2005H7.2' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1959 | Q11 | Are there any ADAM3A SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain and Whole Blood samples tested there are no SNPs within the gene ADAM3A that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'ADAM3A' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.505 | Q11 | Are there any NLRP10 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cortex samples tested there are no SNPs within the gene NLRP10 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'NLRP10' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.342 | Q11 | Are there any LEPROTL1 SNPs that have a statistically significant adjusted SMR p-value in association with Amyotrophic Lateral Sclerosis and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve, Skeletal Muscle and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene LEPROTL1 that are significantly associated with Amyotrophic Lateral Sclerosis. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'ALS' AND Gene = 'LEPROTL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1198 | Q11 | Are there any IGHGP SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | Yes, the IGHGP gene has 1 SNP that is statistically significant in Alzheimer's Disease:
• rs11627978
• Whole Blood: Adjusted SMR multi-SNP P-value: 2.39e-07; HEIDI: 2.2968e-02 | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'IGHGP' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [{'UUID': 'NDD_SMR_genes_all_update_text_1500533', 'Gene': 'IGHGP', 'topRSID': 'rs11627978', 'p_SMR_multi': 2.39192e-07, 'Omic_tissue': 'Whole Blood', 'p_HEIDI': 0.02296792}] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.29 | Q11 | Are there any STYXL1 SNPs that have a statistically significant adjusted SMR p-value in association with Progressive supranuclear palsy and what tissues are they significant in? | No, based on the Cerebellum, Whole Brain, Whole Blood, Cortex, Frontal Cortex, Cerebellar Hemisphere, Caudate Basal Ganglia, Tibial Nerve, Skeletal Muscle, Hippocampus, Multi Ancestry Whole Brain and Hypothalamus samples tested there are no SNPs within the gene STYXL1 that are significantly associated with Progressive supranuclear palsy. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PSP' AND Gene = 'STYXL1' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1227 | Q11 | Are there any TRIM60P14 SNPs that have a statistically significant adjusted SMR p-value in association with Alzheimer's Disease and what tissues are they significant in? | No, based on the Prefrontal Cortex samples tested there are no SNPs within the gene TRIM60P14 that are significantly associated with Alzheimer's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'AD' AND Gene = 'TRIM60P14' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
Q11.1434 | Q11 | Are there any RAB11FIP4 SNPs that have a statistically significant adjusted SMR p-value in association with Parkinson's Disease and what tissues are they significant in? | No, based on the Whole Brain, Whole Blood, Tibial Nerve and Multi Ancestry Whole Brain samples tested there are no SNPs within the gene RAB11FIP4 that are significantly associated with Parkinson's Disease. | SELECT UUID, Gene, topRSID, p_SMR_multi, Omic_tissue, p_HEIDI
FROM `{project_id}.{dataset_name}.NeurodegenerativeDiseases_SMR_Genes_Full`
WHERE Disease = 'PD' AND Gene = 'RAB11FIP4' AND p_SMR_multi < 2.95e-6
ORDER BY p_SMR_multi
LIMIT 100 | [] | refined | Select, Order By, Multi-Filter, Threshold | SMR Significance |
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