uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
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Q6.1340 | Q6 | What genes does Dantrolene Sodium target when it's used to treat Spinal cord injury? | When used to treat Spinal cord injury, the drug Dantrolene Sodium targets the genes RYR3 and RYR1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dantrolene sodium%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_1100267', 'drugName': 'Dantrolene Sodium', 'tradeNames_list': "['Dantrium', 'Dantrolene sodium', 'Revonto', 'Ryanodex']", 'syns_list': "['Dantamacrin', 'Dantrolen', 'Dantrolene sodiumDantrolene sodium heptahydrate', 'Dantrolene sodium hydrateDantrolene sodium salt hemiheptahy... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.12 | Q6 | What genes does Betamethasone Dipropionate target when it's used to treat skin disease? | When used to treat skin disease, the drug Betamethasone Dipropionate targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%betamethasone dipropionate%" OR LOWER(tradeNames_... | [{'UUID': 'DrugTargetsIndication121923_text_220894', 'drugName': 'Betamethasone Dipropionate', 'tradeNames_list': "['Alphatrex', 'Betamethasone dipropionate', 'Diprolene', 'Diprolene afDiprosone', 'Sernivo']", 'syns_list': "['Betamethasone (as dipropionate)', 'Betamethasone 17,21-dipropionateBetamethasone dipropionate'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.402 | Q6 | What genes does Capsaicin target when it's used to treat Muscle spasm? | When used to treat Muscle spasm, the drug Capsaicin targets the gene TRPV1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%capsaicin%" OR LOWER(tradeNames_list) LIKE "%caps... | [{'UUID': 'DrugTargetsIndication121923_text_993223', 'drugName': 'Capsaicin', 'tradeNames_list': "['Qutenza', 'Zacin', 'Zostrix', 'Zostrix hp']", 'syns_list': "['ALGRX 4975', 'ALGRX-4975', 'Ausanil', 'Axsain', 'Capsaicin', 'Capzasin-hpCntx-4975', 'Dolenon', 'FEMA NO. 3404', 'Mioton', 'NGX-1998', 'NGX-4010NSC-56353', 'N... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.288 | Q6 | What genes does Mirabegron target when it's used to treat heart failure? | Mirabegron has not been approved by the FDA as a treatment for heart failure, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is ADRB3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%mirabegron%" OR LOWER(tradeNames_list) LIKE "%mir... | [{'UUID': 'DrugTargetsIndication121923_text_937765', 'drugName': 'Mirabegron', 'tradeNames_list': "['Betmiga', 'Myrbetriq', 'Myrbetriq granules']", 'syns_list': "['Betanis', 'Mirabegron', 'YM-178', 'YM178']", 'target': 'ENSG00000188778', 'approvedSymbol': 'ADRB3', 'approvedName': 'adrenoceptor beta 3', 'mesh_heading': ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1075 | Q6 | What genes does Testosterone Cypionate target when it's used to treat orchitis? | When used to treat orchitis, the drug Testosterone Cypionate targets the gene AR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%testosterone cypionate%" OR LOWER(tradeNames_list... | [{'UUID': 'DrugTargetsIndication121923_text_921014', 'drugName': 'Testosterone Cypionate', 'tradeNames_list': "['Andro-Cyp', 'Depandro', 'Depo-testosterone', 'Depotest', 'TestosteroneTestosterone cypionate']", 'syns_list': "['Depo-Testadiol', 'NSC-9157Testosterone 17.beta.-cyclopentanepropionate', 'Testosterone cipiona... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1201 | Q6 | What genes does Loxapine target when it's used to treat schizophrenia? | When used to treat schizophrenia, the drug Loxapine targets the genes HTR2C, DRD2, DRD3, DRD4, and HTR2A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%loxapine%" OR LOWER(tradeNames_list) LIKE "%loxap... | [{'UUID': 'DrugTargetsIndication121923_text_149114', 'drugName': 'Loxapine', 'tradeNames_list': "['Adasuve', 'Loxitane intramuscular [as hydrochloride]Loxitane-c oral suspension [as hydrochloride]']", 'syns_list': "['CL 62,362', 'CL-62362', 'Loxapac', 'Loxapine', 'Loxitane', 'SUM 3170SUM-3170']", 'target': 'ENSG0000014... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1746 | Q6 | What genes does Irinotecan Hydrochloride target when it's used to treat leukemia? | Irinotecan Hydrochloride has not been approved by the FDA as a treatment for leukemia, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is TOP1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%irinotecan hydrochloride%" OR LOWER(tradeNames_li... | [{'UUID': 'DrugTargetsIndication121923_text_940710', 'drugName': 'Irinotecan Hydrochloride', 'tradeNames_list': "['Campto', 'Camptosar', 'Irinotecan hydrochloride', 'Onivyde']", 'syns_list': "['CPT-11', 'DQ-2805', 'Irinotecan hydrochlorideIrinotecan hydrochloride anhydrous', 'Irinotecan hydrochloride hydrateIrinotecan ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.697 | Q6 | What genes does Ribavirin target when it's used to treat cirrhosis of liver? | When used to treat cirrhosis of liver, the drug Ribavirin targets the gene IMPDH1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ribavirin%" OR LOWER(tradeNames_list) LIKE "%riba... | [{'UUID': 'DrugTargetsIndication121923_text_937565', 'drugName': 'Ribavirin', 'tradeNames_list': "['Copegus', 'Rebetol', 'Ribapak', 'Ribasphere', 'Ribavarin', 'RibavirinRibofluranosyl Carboxamide', 'Tribavirin', 'Viramid', 'Virazid', 'Virazole']", 'syns_list': "['Cotronak', 'NSC-163039', 'Ribavirin', 'Ribavirin biopart... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1632 | Q6 | What genes does Baclofen target when it's used to treat Spinal cord injury? | When used to treat Spinal cord injury, the drug Baclofen targets the genes GABBR1 and GABBR2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%baclofen%" OR LOWER(tradeNames_list) LIKE "%baclo... | [{'UUID': 'DrugTargetsIndication121923_text_1193247', 'drugName': 'Baclofen', 'tradeNames_list': "['Baclofen', 'Baclospas-10', 'Fleqsuvy', 'Gablofen', 'Kemstro', 'LioresalLioresal intrath', 'Lyflex', 'Lyvispah', 'Ozobax']", 'syns_list': "['(rs)-baclofen', 'BA-34,647', 'BA-34647', 'Baclofen', 'Fleqsuvy', 'LyvispahNSC-75... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1877 | Q6 | What genes does Lamotrigine target when it's used to treat bipolar disorder? | When used to treat bipolar disorder, the drug Lamotrigine targets the genes SCN1A, SCN5A, SCN4A, SCN7A, SCN2A, SCN9A, SCN3A, SCN11A, SCN8A, and SCN10A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lamotrigine%" OR LOWER(tradeNames_list) LIKE "%la... | [{'UUID': 'DrugTargetsIndication121923_text_653062', 'drugName': 'Lamotrigine', 'tradeNames_list': "['Lamictal', 'Lamictal cd', 'Lamictal odt', 'Lamictal xr', 'Lamotrigine']", 'syns_list': "['BW 430C', 'BW-430C', 'Lamotrigine', 'NSC-759171']", 'target': 'ENSG00000144285', 'approvedSymbol': 'SCN1A', 'approvedName': 'sod... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.696 | Q6 | What genes does Panobinostat target when it's used to treat breast cancer? | Panobinostat has not been approved by the FDA as a treatment for breast cancer, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are HDAC1, HDAC3, HDAC6, HDAC2, HDAC5, HDAC7, HDAC8, HDAC11, HDAC4, HDAC9, and HDAC10. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%panobinostat%" OR LOWER(tradeNames_list) LIKE "%p... | [{'UUID': 'DrugTargetsIndication121923_text_1080930', 'drugName': 'Panobinostat', 'tradeNames_list': "['Farydak']", 'syns_list': "['LBH-589', 'LBH589', 'Panobinostat', 'Panobinostat hydrate']", 'target': 'ENSG00000116478', 'approvedSymbol': 'HDAC1', 'approvedName': 'histone deacetylase 1', 'mesh_heading': 'Breast Neopl... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.858 | Q6 | What genes does Lenalidomide target when it's used to treat anemia (phenotype)? | When used to treat anemia (phenotype), the drug Lenalidomide targets the genes CRBN, DDB1, CUL4A, and RBX1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lenalidomide%" OR LOWER(tradeNames_list) LIKE "%l... | [{'UUID': 'DrugTargetsIndication121923_text_1106172', 'drugName': 'Lenalidomide', 'tradeNames_list': "['Revlimid']", 'syns_list': "['CC-5013', 'CDC-501', 'Lenalidomide', 'NSC-747972', 'SYP-1512']", 'target': 'ENSG00000113851', 'approvedSymbol': 'CRBN', 'approvedName': 'cereblon', 'mesh_heading': 'Anemia', 'efo_term': '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.162 | Q6 | What genes does Dextroamphetamine target when it's used to treat attention deficit hyperactivity disorder? | When used to treat attention deficit hyperactivity disorder, the drug Dextroamphetamine targets the genes SLC6A2, SLC18A2, and SLC6A3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dextroamphetamine%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_418424', 'drugName': 'Dextroamphetamine', 'tradeNames_list': "['Dexedrine', 'Dextrostat', 'Xelstrym']", 'syns_list': "['Amfetamine, (s)-', 'Amphetamine, d-', 'D-amphetamine', 'DexamfetamineDexampex', 'Dexamphetamine', 'Dexedrine', 'Dexidrine', 'DextroamphetamineDextroamphetam... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.902 | Q6 | What genes does Amphetamine Sulfate target when it's used to treat narcolepsy-cataplexy syndrome? | When used to treat narcolepsy-cataplexy syndrome, the drug Amphetamine Sulfate targets the genes SLC6A2 and SLC6A3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%amphetamine sulfate%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_440698', 'drugName': 'Amphetamine Sulfate', 'tradeNames_list': "['Amphetamine sulfate', 'Benzadrine', 'Evekeo', 'Evekeo odt']", 'syns_list': "['Amfetamine sulfate', 'Amfetamine sulphate', 'Amphetamine SulfateAmphetamine sulfate', 'Astedin', 'Benzedrine', 'Dl-amphetamine sulfa... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1576 | Q6 | What genes does Lansoprazole target when it's used to treat gastroesophageal reflux disease? | When used to treat gastroesophageal reflux disease, the drug Lansoprazole targets the genes ATP4A and ATP4B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lansoprazole%" OR LOWER(tradeNames_list) LIKE "%l... | [{'UUID': 'DrugTargetsIndication121923_text_1098431', 'drugName': 'Dexlansoprazole', 'tradeNames_list': "['Dexilant', 'Dexilant solutab', 'Kapidex']", 'syns_list': "['(r)-lansoprazole', 'Dexlansoprazole', 'Kapidex', 'Lansoprazole r-formLansoprazole, (r)-', 'NSC-758710', 'T-168390', 'TAK-390']", 'target': 'ENSG000001056... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.260 | Q6 | What genes does Tadalafil target when it's used to treat erectile dysfunction? | When used to treat erectile dysfunction, the drug Tadalafil targets the gene PDE5A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%tadalafil%" OR LOWER(tradeNames_list) LIKE "%tada... | [{'UUID': 'DrugTargetsIndication121923_text_1094099', 'drugName': 'Tadalafil', 'tradeNames_list': "['Adcirca', 'Cialis', 'Tadliq']", 'syns_list': "['IC-351', 'IC351', 'LY-450190', 'LY450190', 'NSC-750236', 'NSC-759172Tadalafil', 'Tadalafil mylan', 'Trans-tadalafil']", 'target': 'ENSG00000138735', 'approvedSymbol': 'PDE... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.339 | Q6 | What genes does Aripiprazole Lauroxil target when it's used to treat Tourette syndrome? | When used to treat Tourette syndrome, the drug Aripiprazole Lauroxil targets the genes DRD2, HTR2A, and HTR1A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%aripiprazole lauroxil%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_158028', 'drugName': 'Aripiprazole Lauroxil', 'tradeNames_list': "['Aristada', 'Aristada initio kit']", 'syns_list': "['ALKS 9072', 'ALKS-9070', 'ALKS-9072', 'Aripiprazole lauroxilAristada initio', 'RDC-3317', 'RDC3317']", 'target': 'ENSG00000149295', 'approvedSymbol': 'DRD2'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1881 | Q6 | What genes does Glasdegib Maleate target when it's used to treat acute myeloid leukemia? | When used to treat acute myeloid leukemia, the drug Glasdegib Maleate targets the gene SMO. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%glasdegib maleate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_1072617', 'drugName': 'Glasdegib Maleate', 'tradeNames_list': "['Daurismo']", 'syns_list': "['Glasdegib maleate', 'PF-04449913 MALEATE']", 'target': 'ENSG00000128602', 'approvedSymbol': 'SMO', 'approvedName': 'smoothened, frizzled class receptor', 'mesh_heading': 'Leukemia, M... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1048 | Q6 | What genes does Belzutifan target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Belzutifan targets the gene EPAS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%belzutifan%" OR LOWER(tradeNames_list) LIKE "%bel... | [{'UUID': 'DrugTargetsIndication121923_text_1192111', 'drugName': 'Belzutifan', 'tradeNames_list': "['Welireg']", 'syns_list': "['Belzutifan', 'MK-6482', 'MK6482', 'Mk-6482', 'PT-2977', 'PT2977', 'Pt 2977Pt2977']", 'target': 'ENSG00000116016', 'approvedSymbol': 'EPAS1', 'approvedName': 'endothelial PAS domain protein 1... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.521 | Q6 | What genes does Bupivacaine target when it's used to treat Chronic pain? | Bupivacaine has not been approved by the FDA as a treatment for Chronic pain, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is SCN4A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bupivacaine%" OR LOWER(tradeNames_list) LIKE "%bu... | [{'UUID': 'DrugTargetsIndication121923_text_663106', 'drugName': 'Bupivacaine', 'tradeNames_list': "['Anekain', 'Exparel', 'Marcaine', 'Posimir', 'Sensorcaine']", 'syns_list': "['Bucaine', 'Bupivacaine', 'Bupivacaine liposome', 'LIQ-865', 'LIQ865Liposomal bupivacaine', 'MarcaineRopivacaine hydrochloride impurity, bupiv... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1363 | Q6 | What genes does Mirabegron target when it's used to treat Polyuria? | When used to treat Polyuria, the drug Mirabegron targets the gene ADRB3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%mirabegron%" OR LOWER(tradeNames_list) LIKE "%mir... | [{'UUID': 'DrugTargetsIndication121923_text_937773', 'drugName': 'Mirabegron', 'tradeNames_list': "['Betmiga', 'Myrbetriq', 'Myrbetriq granules']", 'syns_list': "['Betanis', 'Mirabegron', 'YM-178', 'YM178']", 'target': 'ENSG00000188778', 'approvedSymbol': 'ADRB3', 'approvedName': 'adrenoceptor beta 3', 'mesh_heading': ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1024 | Q6 | What genes does Naproxen target when it's used to treat vaginal inflammation? | When used to treat vaginal inflammation, the drug Naproxen targets the genes PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%naproxen%" OR LOWER(tradeNames_list) LIKE "%napro... | [{'UUID': 'DrugTargetsIndication121923_text_838544', 'drugName': 'Naproxen', 'tradeNames_list': "['Aleve', 'Anaprox', 'Arthrosin 250', 'Arthrosin 250 ec', 'Arthrosin 500Arthrosin 500 ec', 'Condrotec', 'Ec-naprosyn', 'Equiproxen', 'Feminax ultraGrenoxal', 'Kenosyn', 'Laraflex', 'Napratec op', 'Naprosyn', 'Naprosyn 375Na... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.775 | Q6 | What genes does Indomethacin target when it's used to treat rheumatic disease? | When used to treat rheumatic disease, the drug Indomethacin targets the genes PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%indomethacin%" OR LOWER(tradeNames_list) LIKE "%i... | [{'UUID': 'DrugTargetsIndication121923_text_828376', 'drugName': 'Indomethacin', 'tradeNames_list': "['Artracin', 'Artracin sr', 'Berlind 75 ret', 'Flexin-25 continusFlexin-50 continus', 'Flexin-75 continus', 'Imbrilon', 'Indo-lemmonIndo-paed', 'Indocid ret', 'Indocid-r', 'Indocin', 'Indocin sr', 'IndodermIndoflex', 'I... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1748 | Q6 | What genes does Ponatinib target when it's used to treat acute lymphoblastic leukemia? | Ponatinib has not been approved by the FDA as a treatment for acute lymphoblastic leukemia, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are ABL1 and BCR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ponatinib%" OR LOWER(tradeNames_list) LIKE "%pona... | [{'UUID': 'DrugTargetsIndication121923_text_749495', 'drugName': 'Ponatinib Hydrochloride', 'tradeNames_list': "['Iclusig']", 'syns_list': "['AP-24534 HCL', 'AP24534 HCL', 'Ponatinib hydrochloride']", 'target': 'ENSG00000097007', 'approvedSymbol': 'ABL1', 'approvedName': 'ABL proto-oncogene 1, non-receptor tyrosine kin... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.768 | Q6 | What genes does Oxymetazoline Hydrochloride target when it's used to treat Nasal congestion? | When used to treat Nasal congestion, the drug Oxymetazoline Hydrochloride targets the genes ADRA1A, ADRA1D, ADRA1B, ADRA2A, ADRA2C, and ADRA2B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%oxymetazoline hydrochloride%" OR LOWER(tradeNames... | [{'UUID': 'DrugTargetsIndication121923_text_417239', 'drugName': 'Oxymetazoline Hydrochloride', 'tradeNames_list': "['Afrazine', 'Ocuclear', 'Rhofade', 'Upneeq', 'Visine', 'Visine l.r.']", 'syns_list': "['Agn-199201', 'NSC-757254', 'Oximetazoline hydrochlorideOxymetazoline hcl', 'Oxymetazoline hydrochloride', 'SCH 9384... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1256 | Q6 | What genes does Levetiracetam target when it's used to treat brain neoplasm? | Levetiracetam has not been approved by the FDA as a treatment for brain neoplasm, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are CACNA1B and SV2A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%levetiracetam%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_914924', 'drugName': 'Levetiracetam', 'tradeNames_list': "['Desitrend', 'Elepsia xr', 'Keppra', 'Keppra xr', 'LevetiracetamLevetiracetam in sodium chloride', 'Matever', 'Spritam']", 'syns_list': "['AGB-101', 'Elepsia', 'Levetiracetam', 'Levetiracetam accordLevetiracetam actav... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1213 | Q6 | What genes does Ribavirin target when it's used to treat fibrosis? | When used to treat fibrosis, the drug Ribavirin targets the gene IMPDH1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ribavirin%" OR LOWER(tradeNames_list) LIKE "%riba... | [{'UUID': 'DrugTargetsIndication121923_text_937567', 'drugName': 'Ribavirin', 'tradeNames_list': "['Copegus', 'Rebetol', 'Ribapak', 'Ribasphere', 'Ribavarin', 'RibavirinRibofluranosyl Carboxamide', 'Tribavirin', 'Viramid', 'Virazid', 'Virazole']", 'syns_list': "['Cotronak', 'NSC-163039', 'Ribavirin', 'Ribavirin biopart... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1469 | Q6 | What genes does Ixazomib Citrate target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Ixazomib Citrate targets the genes PSMD1, PSMB2, PSMB1, PSMB5, PSMB8, PSMB9, PSMB6, PSMD14, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB10, PSMB11, PSMB3, PSMB4, PSMB7, ADRM1, PSMC2, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD2, PSMD3, PSMD12, PSMD11, PSMD6, PSMD7, PSMD... | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ixazomib citrate%" OR LOWER(tradeNames_list) LIKE... | [{'UUID': 'DrugTargetsIndication121923_text_327015', 'drugName': 'Ixazomib Citrate', 'tradeNames_list': "['Ninlaro']", 'syns_list': "['Ixazomib citrate', 'MLN-9708', 'MLN9708']", 'target': 'ENSG00000126067', 'approvedSymbol': 'PSMB2', 'approvedName': 'proteasome 20S subunit beta 2', 'mesh_heading': 'Neoplasms', 'efo_te... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1984 | Q6 | What genes does Prednisone target when it's used to treat systemic lupus erythematosus? | When used to treat systemic lupus erythematosus, the drug Prednisone targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%prednisone%" OR LOWER(tradeNames_list) LIKE "%pre... | [{'UUID': 'DrugTargetsIndication121923_text_218677', 'drugName': 'Prednisone', 'tradeNames_list': "['Cortan', 'Cortancyl', 'Decortisyl', 'Delta-dome', 'Deltasone', 'FernisoneLiquid pred', 'Lodotra', 'Meticorten', 'Orasone', 'Paracort', 'Prednicen-mPrednisone', 'Prednisone intensol', 'Rayos', 'Servisone', 'Sterapred']",... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.527 | Q6 | What genes does Lamotrigine target when it's used to treat Bilateral tonic-clonic seizure? | When used to treat Bilateral tonic-clonic seizure, the drug Lamotrigine targets the genes SCN1A, SCN5A, SCN4A, SCN7A, SCN2A, SCN9A, SCN3A, SCN11A, SCN8A, and SCN10A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lamotrigine%" OR LOWER(tradeNames_list) LIKE "%la... | [{'UUID': 'DrugTargetsIndication121923_text_653149', 'drugName': 'Lamotrigine', 'tradeNames_list': "['Lamictal', 'Lamictal cd', 'Lamictal odt', 'Lamictal xr', 'Lamotrigine']", 'syns_list': "['BW 430C', 'BW-430C', 'Lamotrigine', 'NSC-759171']", 'target': 'ENSG00000144285', 'approvedSymbol': 'SCN1A', 'approvedName': 'sod... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.23 | Q6 | What genes does Acetaminophen target when it's used to treat infection? | Acetaminophen has not been approved by the FDA as a treatment for infection, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are PTGS2, PTGS1, TRPV1, and FAAH. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%acetaminophen%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_829653', 'drugName': 'Acetaminophen', 'tradeNames_list': '[\'Abdine\', \'Acephen\', \'Acetaminophen\', \'Alvedon\', \'Angiers\', \'CalpolCalpol six plus\', \'Calpol six plus fastmelts\', \'Child lemsip\', \'CupanolDafalgan\', \'Datril\', \'Disprol\', \'Disprol infant\', \'Dis... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.361 | Q6 | What genes does Lisinopril target when it's used to treat congestive heart failure? | When used to treat congestive heart failure, the drug Lisinopril targets the gene ACE. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lisinopril%" OR LOWER(tradeNames_list) LIKE "%lis... | [{'UUID': 'DrugTargetsIndication121923_text_1091708', 'drugName': 'Lisinopril', 'tradeNames_list': "['Acemin', 'Carace', 'Lisinopril', 'Lisopress', 'Prinivil', 'Qbrelis', 'Zestril']", 'syns_list': "['Lisinopril', 'Lisinopril dihydrate', 'Lisinopril hydrate', 'MK-521Ranolip']", 'target': 'ENSG00000159640', 'approvedSymb... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1288 | Q6 | What genes does Topotecan target when it's used to treat cancer? | When used to treat cancer, the drug Topotecan targets the gene TOP1MT. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%topotecan%" OR LOWER(tradeNames_list) LIKE "%topo... | [{'UUID': 'DrugTargetsIndication121923_text_1193672', 'drugName': 'Topotecan', 'tradeNames_list': "['Hycamtin', 'Potactasol']", 'syns_list': "['Ff-10850 (liposomal topotecan)', 'Hycamptamine', 'Hycamptin', 'HycamtinNSC-609699', 'NSC-641007', 'Nogitecan', 'SKF-104864', 'Topotecan']", 'target': 'ENSG00000184428', 'approv... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1326 | Q6 | What genes does Rosuvastatin Calcium target when it's used to treat hyperlipoproteinemia type 3? | When used to treat hyperlipoproteinemia type 3, the drug Rosuvastatin Calcium targets the gene HMGCR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%rosuvastatin calcium%" OR LOWER(tradeNames_list) ... | [{'UUID': 'DrugTargetsIndication121923_text_1104219', 'drugName': 'Rosuvastatin Calcium', 'tradeNames_list': "['Crestor', 'Ezallor', 'Ezallor sprinkle', 'Rosuvastatin calcium']", 'syns_list': "['Fortius', 'NSC-747274', 'NSC-758930', 'Rostar', 'Rosuvastatin (as calcium)Rosuvastatin calcium', 'Rosuvastatin calcium saltRo... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1683 | Q6 | What genes does Bempedoic Acid target when it's used to treat familial hypercholesterolemia? | When used to treat familial hypercholesterolemia, the drug Bempedoic Acid targets the gene ACLY. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bempedoic acid%" OR LOWER(tradeNames_list) LIKE "... | [{'UUID': 'DrugTargetsIndication121923_text_1191843', 'drugName': 'Bempedoic Acid', 'tradeNames_list': "['Nexletol']", 'syns_list': "['Bempedoic acid', 'ESP-55016', 'ETC-1002', 'ETC1002']", 'target': 'ENSG00000131473', 'approvedSymbol': 'ACLY', 'approvedName': 'ATP citrate lyase', 'mesh_heading': 'Hyperlipoproteinemia ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.344 | Q6 | What genes does Megestrol Acetate target when it's used to treat Cachexia? | When used to treat Cachexia, the drug Megestrol Acetate targets the gene PGR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%megestrol acetate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_940575', 'drugName': 'Megestrol Acetate', 'tradeNames_list': "['Megace', 'Megace es', 'Megestrol acetate', 'Ovaban']", 'syns_list': "['5071', 'BDH 1298', 'BDH-1298', 'Chronopil', 'Megesterol acetate', 'MegestrolMegestrol 17.alpha.-acetate', 'Megestrol acetate', 'NSC-71423', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.437 | Q6 | What genes does Imiquimod target when it's used to treat keratosis? | When used to treat keratosis, the drug Imiquimod targets the gene TLR7. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%imiquimod%" OR LOWER(tradeNames_list) LIKE "%imiq... | [{'UUID': 'DrugTargetsIndication121923_text_919622', 'drugName': 'Imiquimod', 'tradeNames_list': "['Aldara', 'Imiquimod', 'Zyclara']", 'syns_list': "['Aldara', 'Imiquimod', 'NSC-369100', 'NSC-759651', 'R-837', 'S-26308', 'S26308Tmx-101']", 'target': 'ENSG00000196664', 'approvedSymbol': 'TLR7', 'approvedName': 'toll lik... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.479 | Q6 | What genes does Brimonidine Tartrate target when it's used to treat ocular hypertension? | When used to treat ocular hypertension, the drug Brimonidine Tartrate targets the genes ADRA2A, ADRA2C, and ADRA2B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%brimonidine tartrate%" OR LOWER(tradeNames_list) ... | [{'UUID': 'DrugTargetsIndication121923_text_1034086', 'drugName': 'Brimonidine Tartrate', 'tradeNames_list': "['Alphagan', 'Alphagan p', 'Brimonidine tartrate', 'Brymont', 'LumifyMirvaso', 'Qoliana']", 'syns_list': "['AGN 190342-LF', 'AGN-190342-LF', 'AGN-190342LF', 'Brimonidine d-tartrateBrimonidine tartrate', 'Bromox... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.220 | Q6 | What genes does Clobetasol Propionate target when it's used to treat psoriasis? | When used to treat psoriasis, the drug Clobetasol Propionate targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%clobetasol propionate%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_243471', 'drugName': 'Clobetasol Propionate', 'tradeNames_list': "['Clarelux', 'Clobaderm', 'Clobetasol propionateClobetasol propionate (emollient)', 'Clobex', 'Cormax', 'DermovateDermovate nn', 'Embeline', 'Embeline e', 'Etrivex', 'Impeklo', 'ImpoyzOlux', 'Olux e', 'Temovate... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.919 | Q6 | What genes does Trametinib target when it's used to treat meningioma? | Trametinib has not been approved by the FDA as a treatment for meningioma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are MAP2K2 and MAP2K1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%trametinib%" OR LOWER(tradeNames_list) LIKE "%tra... | [{'UUID': 'DrugTargetsIndication121923_text_928690', 'drugName': 'Trametinib', 'tradeNames_list': "['Mekinist']", 'syns_list': "['GSK-1120212', 'GSK1120212', 'JTP 74057', 'JTP-74057', 'TMT-212', 'TMT212Tmt212', 'Trametinib']", 'target': 'ENSG00000126934', 'approvedSymbol': 'MAP2K2', 'approvedName': 'mitogen-activated p... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1237 | Q6 | What genes does Liraglutide target when it's used to treat MODY? | When used to treat MODY, the drug Liraglutide targets the gene GLP1R. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%liraglutide%" OR LOWER(tradeNames_list) LIKE "%li... | [{'UUID': 'DrugTargetsIndication121923_text_1044539', 'drugName': 'Liraglutide', 'tradeNames_list': "['Saxenda', 'Victoza']", 'syns_list': "['Liraglutide', 'Liraglutide (rdna origin)', 'Liraglutide recombinantNN-2211', 'NN-9924', 'NN2211', 'NN9924', 'NNC 90-1170', 'NNC-90-1170']", 'target': 'ENSG00000112164', 'approved... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1597 | Q6 | What genes does Cyclosporine target when it's used to treat infection? | Cyclosporine has not been approved by the FDA as a treatment for infection, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is PPIA. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%cyclosporine%" OR LOWER(tradeNames_list) LIKE "%c... | [{'UUID': 'DrugTargetsIndication121923_text_1100730', 'drugName': 'Cyclosporine', 'tradeNames_list': "['Capimune', 'Capsorin', 'Cequa', 'Cyclosporine', 'Deximune', 'GengrafIkervis', 'Neoral', 'Optimmune', 'Restasis', 'Restasis multidoseSandimmun', 'Sandimmune', 'Sangcya', 'Vanquoral', 'Verkazia']", 'syns_list': "['27-4... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1020 | Q6 | What genes does Lusutrombopag target when it's used to treat Thrombocytopenia? | When used to treat Thrombocytopenia, the drug Lusutrombopag targets the gene MPL. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lusutrombopag%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_1056630', 'drugName': 'Lusutrombopag', 'tradeNames_list': "['Mulpleta', 'S-888711']", 'syns_list': "['Lusutrombopag', 'RSC888711', 'S-888711']", 'target': 'ENSG00000117400', 'approvedSymbol': 'MPL', 'approvedName': 'MPL proto-oncogene, thrombopoietin receptor', 'mesh_heading'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1950 | Q6 | What genes does Lenvatinib target when it's used to treat Hodgkins lymphoma? | Lenvatinib has not been approved by the FDA as a treatment for Hodgkins lymphoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are KDR, FLT1, and FLT4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lenvatinib%" OR LOWER(tradeNames_list) LIKE "%len... | [{'UUID': 'DrugTargetsIndication121923_text_690773', 'drugName': 'Lenvatinib', 'tradeNames_list': "['Kisplyx', 'Lenvima']", 'syns_list': "['E-7080', 'ER-203492-00', 'Lenvatinib']", 'target': 'ENSG00000128052', 'approvedSymbol': 'KDR', 'approvedName': 'kinase insert domain receptor', 'mesh_heading': 'Hodgkin Disease', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.96 | Q6 | What genes does Regorafenib target when it's used to treat ovarian neoplasm? | Regorafenib has not been approved by the FDA as a treatment for ovarian neoplasm, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are KDR, FGFR1, FGFR2, ABL1, BRAF, TEK, FLT1, KIT, FLT4, PDGFRB, PDGFRA, RAF1, EPHA2, FRK, NTRK1, RET, DDR2, and MAPK11. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%regorafenib%" OR LOWER(tradeNames_list) LIKE "%re... | [{'UUID': 'DrugTargetsIndication121923_text_664094', 'drugName': 'Regorafenib', 'tradeNames_list': "['Stivarga']", 'syns_list': "['BAY 73-4506', 'BAY 73-4506 monohydrate', 'BAY-73-4506', 'BAY-734506Regorafenib', 'Regorafenib anhydrous', 'Regorafenib hydrateRegorafenib monohydrate']", 'target': 'ENSG00000128052', 'appro... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1017 | Q6 | What genes does Ezetimibe target when it's used to treat cardiovascular disease? | When used to treat cardiovascular disease, the drug Ezetimibe targets the gene NPC1L1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ezetimibe%" OR LOWER(tradeNames_list) LIKE "%ezet... | [{'UUID': 'DrugTargetsIndication121923_text_1097388', 'drugName': 'Ezetimibe', 'tradeNames_list': "['Ezetimibe', 'Ezetrol', 'Zetia']", 'syns_list': "['Ezetimibe', 'MK0653', 'NSC-758923', 'SCH-58235', 'SCH58235']", 'target': 'ENSG00000015520', 'approvedSymbol': 'NPC1L1', 'approvedName': 'NPC1 like intracellular choleste... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1079 | Q6 | What genes does Bortezomib target when it's used to treat cancer? | When used to treat cancer, the drug Bortezomib targets the genes PSMD1, PSMB2, PSMB1, PSMB5, PSMB8, PSMB9, PSMB6, PSMD14, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB10, PSMB11, PSMB3, PSMB4, PSMB7, ADRM1, PSMC2, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD2, PSMD3, PSMD12, PSMD11, PSMD6, PSMD7, PSMD13, PSMD... | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bortezomib%" OR LOWER(tradeNames_list) LIKE "%bor... | [{'UUID': 'DrugTargetsIndication121923_text_348844', 'drugName': 'Bortezomib', 'tradeNames_list': "['Velcade']", 'syns_list': "['Bortezomib', 'Bortezomib accord', 'Bortezomib hydrate', 'LDP-341NSC-681239', 'PS-341', 'Velcade']", 'target': 'ENSG00000222028', 'approvedSymbol': 'PSMB11', 'approvedName': 'proteasome subuni... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1101 | Q6 | What genes does Carvedilol target when it's used to treat heart failure? | When used to treat heart failure, the drug Carvedilol targets the genes ADRA1A, ADRB2, ADRB1, ADRB3, ADRA1D, and ADRA1B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%carvedilol%" OR LOWER(tradeNames_list) LIKE "%car... | [{'UUID': 'DrugTargetsIndication121923_text_357043', 'drugName': 'Carvedilol', 'tradeNames_list': "['Carvedilol', 'Coreg', 'Coreg CR', 'Eucardic 12.5', 'Eucardic 25Eucardic 3.125', 'Eucardic 6.25']", 'syns_list': "['BM 14.190', 'BM-14-190', 'BM-14.190', 'BM-14190', 'C07AG02', 'CarvedilolCoronis', 'DQ-2466', 'Dilatrend'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1586 | Q6 | What genes does Phenylephrine Hydrochloride target when it's used to treat Nasal congestion? | When used to treat Nasal congestion, the drug Phenylephrine Hydrochloride targets the genes ADRA1A, ADRA1D, and ADRA1B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%phenylephrine hydrochloride%" OR LOWER(tradeNames... | [{'UUID': 'DrugTargetsIndication121923_text_416698', 'drugName': 'Phenylephrine Hydrochloride', 'tradeNames_list': "['Afrin 4 hour nasal spray', 'Biomydrin', 'Biorphen', 'Fenilfar', 'FenoxMydfrin', 'Nazex', 'Neo-synephrine', 'Neosynephrine', 'NostrilNurofen sinus pain relief', 'Phenylephrine hydrochloride', 'PrefrinVaz... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1321 | Q6 | What genes does Naproxen Sodium target when it's used to treat ankylosing spondylitis? | When used to treat ankylosing spondylitis, the drug Naproxen Sodium targets the genes PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%naproxen sodium%" OR LOWER(tradeNames_list) LIKE ... | [{'UUID': 'DrugTargetsIndication121923_text_838133', 'drugName': 'Naproxen Sodium', 'tradeNames_list': "['Aleve', 'Anaprox', 'Anaprox ds', 'Naprelan', 'Naproxen sodium', 'Synflex']", 'syns_list': "['BAY-117031', 'BAY117031', 'BAYH6689', 'Naproxen sodiumNaproxen sodium anhydrous', 'Naproxen sodium salt', 'RS-3650']", 't... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.703 | Q6 | What genes does Cariprazine Hydrochloride target when it's used to treat bipolar disorder? | When used to treat bipolar disorder, the drug Cariprazine Hydrochloride targets the genes DRD2 and DRD3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%cariprazine hydrochloride%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_199881', 'drugName': 'Cariprazine Hydrochloride', 'tradeNames_list': "['Vraylar']", 'syns_list': "['Cariprazine hcl', 'Cariprazine hydrochloride', 'RGH-188 HCL']", 'target': 'ENSG00000149295', 'approvedSymbol': 'DRD2', 'approvedName': 'dopamine receptor D2', 'mesh_heading': '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1794 | Q6 | What genes does Naproxen target when it's used to treat rheumatic disease? | When used to treat rheumatic disease, the drug Naproxen targets the genes PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%naproxen%" OR LOWER(tradeNames_list) LIKE "%napro... | [{'UUID': 'DrugTargetsIndication121923_text_838543', 'drugName': 'Naproxen', 'tradeNames_list': "['Aleve', 'Anaprox', 'Arthrosin 250', 'Arthrosin 250 ec', 'Arthrosin 500Arthrosin 500 ec', 'Condrotec', 'Ec-naprosyn', 'Equiproxen', 'Feminax ultraGrenoxal', 'Kenosyn', 'Laraflex', 'Napratec op', 'Naprosyn', 'Naprosyn 375Na... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1005 | Q6 | What genes does Fluorouracil target when it's used to treat actinic keratosis? | When used to treat actinic keratosis, the drug Fluorouracil targets the gene TYMS. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%fluorouracil%" OR LOWER(tradeNames_list) LIKE "%f... | [{'UUID': 'DrugTargetsIndication121923_text_919465', 'drugName': 'Fluorouracil', 'tradeNames_list': "['5.f.u.', 'Accusite', 'Actikerall', 'Adrucil', 'Carac', 'Efudex', 'EfudixFluoro-uracil roche', 'Fluoroplex', 'Fluorouracil', 'Tolak']", 'syns_list': "['5 FU', '5-FU', '5-Fluorouracil', '5-fluoruracil', 'FluorouracilFlu... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.156 | Q6 | What genes does Cyclobenzaprine Hydrochloride target when it's used to treat Muscle spasm? | When used to treat Muscle spasm, the drug Cyclobenzaprine Hydrochloride targets the genes HTR2C and HTR2A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%cyclobenzaprine hydrochloride%" OR LOWER(tradeNam... | [{'UUID': 'DrugTargetsIndication121923_text_151278', 'drugName': 'Cyclobenzaprine Hydrochloride', 'tradeNames_list': "['Amrix', 'Cyclobenzaprine hydrochloride', 'Flexeril']", 'syns_list': "['Cyclobenzaprine hcl', 'Cyclobenzaprine hydrochloride', 'MK-130MK-130 HYDROCHLORIDE', 'MK-130 [AS THE BASE]', 'NSC-169900', 'NSC-1... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1108 | Q6 | What genes does Ponatinib target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Ponatinib targets the genes ABL1 and BCR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ponatinib%" OR LOWER(tradeNames_list) LIKE "%pona... | [{'UUID': 'DrugTargetsIndication121923_text_751070', 'drugName': 'Ponatinib', 'tradeNames_list': "['Iclusig']", 'syns_list': "['AP-24534', 'AP24534', 'Ponatinib']", 'target': 'ENSG00000097007', 'approvedSymbol': 'ABL1', 'approvedName': 'ABL proto-oncogene 1, non-receptor tyrosine kinase', 'mesh_heading': 'Neoplasms', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1719 | Q6 | What genes does Dasatinib target when it's used to treat childhood acute lymphoblastic leukemia? | When used to treat childhood acute lymphoblastic leukemia, the drug Dasatinib targets the genes ABL1, BCR, HCK, SRC, LYN, KIT, PDGFRB, EPHA2, FRK, FYN, LCK, YES1, BLK, FGR, and SRMS. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dasatinib%" OR LOWER(tradeNames_list) LIKE "%dasa... | [{'UUID': 'DrugTargetsIndication121923_text_713601', 'drugName': 'Dasatinib', 'tradeNames_list': "['Dasatinib', 'Sprycel']", 'syns_list': "['BMS-354825', 'BMS-354825 HYDRATE', 'BMS-354825-03', 'DasatinibDasatinib anhydrous', 'Dasatinib hydrate', 'Dasatinib monohydrateNSC-759877']", 'target': 'ENSG00000097007', 'approve... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1998 | Q6 | What genes does Zanubrutinib target when it's used to treat Mantle cell lymphoma? | When used to treat Mantle cell lymphoma, the drug Zanubrutinib targets the gene BTK. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%zanubrutinib%" OR LOWER(tradeNames_list) LIKE "%z... | [{'UUID': 'DrugTargetsIndication121923_text_1025175', 'drugName': 'Zanubrutinib', 'tradeNames_list': "['Brukinsa']", 'syns_list': "['BGB-3111', 'Bgb-3111', 'Zanubrutinib']", 'target': 'ENSG00000010671', 'approvedSymbol': 'BTK', 'approvedName': 'Bruton tyrosine kinase', 'mesh_heading': 'Lymphoma, Mantle-Cell', 'efo_term... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.796 | Q6 | What genes does Diazepam target when it's used to treat Stiff-Person syndrome? | When used to treat Stiff-Person syndrome, the drug Diazepam targets the genes GABRA1, GABRB2, GABRG2, GABRB3, GABRA4, GABRG3, GABRQ, GABRA3, GABRP, GABRD, GABRG1, GABRB1, GABRE, GABRA2, GABRA5, and GABRA6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%diazepam%" OR LOWER(tradeNames_list) LIKE "%diaze... | [{'UUID': 'DrugTargetsIndication121923_text_960286', 'drugName': 'Diazepam', 'tradeNames_list': "['Alupram 10', 'Alupram 2', 'Alupram 5', 'Apozepam', 'Atensine', 'DialarDialar fte', 'Diastat', 'Diastat acudial', 'Diazepam', 'Diazepam intensolDizac', 'E-Pam', 'Paxel', 'Q-pam', 'Relanium', 'Scriptopam', 'SerenackSolis', ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.587 | Q6 | What genes does Mirabegron target when it's used to treat urgency urinary incontinence? | When used to treat urgency urinary incontinence, the drug Mirabegron targets the gene ADRB3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%mirabegron%" OR LOWER(tradeNames_list) LIKE "%mir... | [{'UUID': 'DrugTargetsIndication121923_text_937774', 'drugName': 'Mirabegron', 'tradeNames_list': "['Betmiga', 'Myrbetriq', 'Myrbetriq granules']", 'syns_list': "['Betanis', 'Mirabegron', 'YM-178', 'YM178']", 'target': 'ENSG00000188778', 'approvedSymbol': 'ADRB3', 'approvedName': 'adrenoceptor beta 3', 'mesh_heading': ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.710 | Q6 | What genes does Everolimus target when it's used to treat breast carcinoma? | When used to treat breast carcinoma, the drug Everolimus targets the gene FKBP1A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%everolimus%" OR LOWER(tradeNames_list) LIKE "%eve... | [{'UUID': 'DrugTargetsIndication121923_text_1087114', 'drugName': 'Everolimus', 'tradeNames_list': "['Afinitor', 'Afinitor disperz', 'Certican', 'Votubia', 'Zortress']", 'syns_list': "['40-o-(2-hydroxyethyl)-rapamycin', 'Everolimus', 'RAD 666', 'RAD-001RAD-666', 'RAD001', 'SDZ-RAD', 'Sdz rad']", 'target': 'ENSG00000088... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1222 | Q6 | What genes does Dexamethasone target when it's used to treat hemophagocytic syndrome? | Dexamethasone has not been approved by the FDA as a treatment for hemophagocytic syndrome, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dexamethasone%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_227724', 'drugName': 'Dexamethasone', 'tradeNames_list': "['Aeroseb-dex', 'Dalalone', 'Decaderm', 'Decadron', 'Decadron-75', 'DecasprayDexacortisyl', 'Dexafree', 'Dexamethasone', 'Dexamethasone intensolDexone', 'Dexone 0.5', 'Dexone 0.75', 'Dexone 1.5', 'Dexone 4', 'DexsolDex... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1308 | Q6 | What genes does Pralatrexate target when it's used to treat mature T-cell and NK-cell non-Hodgkin lymphoma? | When used to treat mature T-cell and NK-cell non-Hodgkin lymphoma, the drug Pralatrexate targets the gene DHFR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%pralatrexate%" OR LOWER(tradeNames_list) LIKE "%p... | [{'UUID': 'DrugTargetsIndication121923_text_1072535', 'drugName': 'Pralatrexate', 'tradeNames_list': "['Folotyn']", 'syns_list': "['NSC-754230', 'PDX', 'Pralatrexate']", 'target': 'ENSG00000228716', 'approvedSymbol': 'DHFR', 'approvedName': 'dihydrofolate reductase', 'mesh_heading': 'Lymphoma, T-Cell, Peripheral', 'efo... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1666 | Q6 | What genes does Idelalisib target when it's used to treat neoplasm of mature B-cells? | When used to treat neoplasm of mature B-cells, the drug Idelalisib targets the gene PIK3CD. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%idelalisib%" OR LOWER(tradeNames_list) LIKE "%ide... | [{'UUID': 'DrugTargetsIndication121923_text_858490', 'drugName': 'Idelalisib', 'tradeNames_list': "['Zydelig']", 'syns_list': "['CAL-101', 'GS-1101', 'GS-11CAL-101', 'Idelalisib']", 'target': 'ENSG00000171608', 'approvedSymbol': 'PIK3CD', 'approvedName': 'phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1270 | Q6 | What genes does Pazopanib target when it's used to treat head and neck squamous cell carcinoma? | Pazopanib has not been approved by the FDA as a treatment for head and neck squamous cell carcinoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are KDR, FGFR1, FGFR3, FLT1, KIT, FLT4, PDGFRB, PDGFRA, LCK, CSF1R, and ITK. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%pazopanib%" OR LOWER(tradeNames_list) LIKE "%pazo... | [{'UUID': 'DrugTargetsIndication121923_text_668678', 'drugName': 'Pazopanib', 'tradeNames_list': "['Votrient']", 'syns_list': "['GW786034', 'NSC-752782', 'Pazopanib']", 'target': 'ENSG00000068078', 'approvedSymbol': 'FGFR3', 'approvedName': 'fibroblast growth factor receptor 3', 'mesh_heading': 'Carcinoma, Squamous Cel... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.493 | Q6 | What genes does Triamcinolone Acetonide target when it's used to treat hearing loss? | Triamcinolone Acetonide has not been approved by the FDA as a treatment for hearing loss, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%triamcinolone acetonide%" OR LOWER(tradeNames_lis... | [{'UUID': 'DrugTargetsIndication121923_text_222157', 'drugName': 'Triamcinolone Acetonide', 'tradeNames_list': "['Adcortyl', 'Adcortyl in orabase', 'Allernaze', 'Aristocort', 'Aristocort aAristogel', 'Audicort', 'Aureocort', 'Azmacort', 'Flutex', 'Gppe ear dps capGppe ear oint', 'Kenacort', 'Kenalog', 'Kenalog in oraba... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.565 | Q6 | What genes does Pimavanserin Tartrate target when it's used to treat Hallucinations? | When used to treat Hallucinations, the drug Pimavanserin Tartrate targets the gene HTR2A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%pimavanserin tartrate%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_205116', 'drugName': 'Pimavanserin Tartrate', 'tradeNames_list': "['Nuplazid']", 'syns_list': "['ACP-103', 'Pimavanserin tartrate']", 'target': 'ENSG00000102468', 'approvedSymbol': 'HTR2A', 'approvedName': '5-hydroxytryptamine receptor 2A', 'mesh_heading': 'Hallucinations', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1151 | Q6 | What genes does Hydrocortisone target when it's used to treat cancer? | Hydrocortisone has not been approved by the FDA as a treatment for cancer, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%hydrocortisone%" OR LOWER(tradeNames_list) LIKE "... | [{'UUID': 'DrugTargetsIndication121923_text_218601', 'drugName': 'Prednisone', 'tradeNames_list': "['Cortan', 'Cortancyl', 'Decortisyl', 'Delta-dome', 'Deltasone', 'FernisoneLiquid pred', 'Lodotra', 'Meticorten', 'Orasone', 'Paracort', 'Prednicen-mPrednisone', 'Prednisone intensol', 'Rayos', 'Servisone', 'Sterapred']",... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1129 | Q6 | What genes does Trifarotene target when it's used to treat acne? | When used to treat acne, the drug Trifarotene targets the gene RARG. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%trifarotene%" OR LOWER(tradeNames_list) LIKE "%tr... | [{'UUID': 'DrugTargetsIndication121923_text_1055617', 'drugName': 'Trifarotene', 'tradeNames_list': "['Aklief']", 'syns_list': "['CD-5789', 'CD5789', 'Trifarotene']", 'target': 'ENSG00000172819', 'approvedSymbol': 'RARG', 'approvedName': 'retinoic acid receptor gamma', 'mesh_heading': 'Acne Vulgaris', 'efo_term': 'acne... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.808 | Q6 | What genes does Thalidomide target when it's used to treat Castleman disease? | Thalidomide has not been approved by the FDA as a treatment for Castleman disease, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are CRBN, DDB1, CUL4A, and RBX1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%thalidomide%" OR LOWER(tradeNames_list) LIKE "%th... | [{'UUID': 'DrugTargetsIndication121923_text_1105098', 'drugName': 'Thalidomide', 'tradeNames_list': "['Talidex', 'Thalomid']", 'syns_list': "['.alpha.-phthalimidoglutarimide', 'Celgene', 'Contergan', 'Distaval', 'K-17Myrin', 'N-phthalylglutamic acid imide', 'NSC-527179', 'NSC-66847Neurosedyn', 'Pantosediv', 'Pharmion',... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.518 | Q6 | What genes does Alpelisib target when it's used to treat breast carcinoma? | When used to treat breast carcinoma, the drug Alpelisib targets the gene PIK3CA. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%alpelisib%" OR LOWER(tradeNames_list) LIKE "%alpe... | [{'UUID': 'DrugTargetsIndication121923_text_939627', 'drugName': 'Alpelisib', 'tradeNames_list': "['Piqray', 'Vijoice']", 'syns_list': "['Alpelisib', 'BYL-719', 'BYL719', 'Byl-719', 'NVP-BYL719', 'Vijoice']", 'target': 'ENSG00000121879', 'approvedSymbol': 'PIK3CA', 'approvedName': 'phosphatidylinositol-4,5-bisphosphate... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.640 | Q6 | What genes does Lorazepam target when it's used to treat anxiety? | When used to treat anxiety, the drug Lorazepam targets the genes GABRA1, GABRB2, GABRG2, GABRB3, GABRA4, GABRG3, GABRQ, GABRA3, GABRP, GABRD, GABRG1, GABRB1, GABRE, GABRA2, GABRA5, and GABRA6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lorazepam%" OR LOWER(tradeNames_list) LIKE "%lora... | [{'UUID': 'DrugTargetsIndication121923_text_958523', 'drugName': 'Lorazepam', 'tradeNames_list': "['Abbloraz', 'Ativan', 'Loraz', 'Lorazepam', 'Lorazepam intensolLorazepam preservative free', 'Loreev xr', 'Temesta']", 'syns_list': "['Lorazepam', 'Lorazepam civ', 'NSC-289758', 'WY-4036']", 'target': 'ENSG00000022355', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1480 | Q6 | What genes does Dronabinol target when it's used to treat Nausea? | When used to treat Nausea, the drug Dronabinol targets the gene CNR1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dronabinol%" OR LOWER(tradeNames_list) LIKE "%dro... | [{'UUID': 'DrugTargetsIndication121923_text_1073256', 'drugName': 'Dronabinol', 'tradeNames_list': "['Dronabinol', 'Marinol', 'Syndros']", 'syns_list': "['.delta.-9-tetrahydrocannabinol', '.delta.1-thc.delta.9-tetrahydrocannabinol', '.delta.9-thc', 'ABBOTT 40566ABBOTT-40566', 'Delta-9-tetrahydrocannabinol', 'Delta-9-th... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1789 | Q6 | What genes does Colchicine target when it's used to treat vascular disease? | Colchicine has not been approved by the FDA as a treatment for vascular disease, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are TUBB4B, TUBB1, TUBA3C, TUBA4A, TUBB3, TUBA1A, TUBB4A, TUBB8, TUBB, TUBA1B, TUBA1C, TUBA3E, TUBB2A, TUBB2B, and TUBB6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%colchicine%" OR LOWER(tradeNames_list) LIKE "%col... | [{'UUID': 'DrugTargetsIndication121923_text_70224', 'drugName': 'Colchicine', 'tradeNames_list': "['Colchicine', 'Colcrys', 'Gloperba', 'Mitigare']", 'syns_list': "['(-)-colchicine', 'Colchcine', 'Colchicine', 'Colchicinum', 'ColchineosColchisol', 'NSC-757']", 'target': 'ENSG00000188229', 'approvedSymbol': 'TUBB4B', 'a... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1546 | Q6 | What genes does Dexamethasone target when it's used to treat choroiditis? | When used to treat choroiditis, the drug Dexamethasone targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dexamethasone%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_227800', 'drugName': 'Dexamethasone', 'tradeNames_list': "['Aeroseb-dex', 'Dalalone', 'Decaderm', 'Decadron', 'Decadron-75', 'DecasprayDexacortisyl', 'Dexafree', 'Dexamethasone', 'Dexamethasone intensolDexone', 'Dexone 0.5', 'Dexone 0.75', 'Dexone 1.5', 'Dexone 4', 'DexsolDex... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1160 | Q6 | What genes does Apixaban target when it's used to treat deep vein thrombosis? | When used to treat deep vein thrombosis, the drug Apixaban targets the gene F10. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%apixaban%" OR LOWER(tradeNames_list) LIKE "%apixa... | [{'UUID': 'DrugTargetsIndication121923_text_710509', 'drugName': 'Apixaban', 'tradeNames_list': "['Eliquis']", 'syns_list': "['Apixaban', 'BMS-562247', 'BMS-562247-01']", 'target': 'ENSG00000126218', 'approvedSymbol': 'F10', 'approvedName': 'coagulation factor X', 'mesh_heading': 'Venous Thrombosis', 'efo_term': 'deep ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.797 | Q6 | What genes does Eluxadoline target when it's used to treat irritable bowel syndrome? | When used to treat irritable bowel syndrome, the drug Eluxadoline targets the gene OPRM1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%eluxadoline%" OR LOWER(tradeNames_list) LIKE "%el... | [{'UUID': 'DrugTargetsIndication121923_text_763315', 'drugName': 'Eluxadoline', 'tradeNames_list': "['Truberzi', 'Viberzi']", 'syns_list': "['Eluxadoline', 'JNJ-27018966']", 'target': 'ENSG00000112038', 'approvedSymbol': 'OPRM1', 'approvedName': 'opioid receptor mu 1', 'mesh_heading': 'Irritable Bowel Syndrome', 'efo_t... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.119 | Q6 | What genes does Axitinib target when it's used to treat clear cell renal carcinoma? | When used to treat clear cell renal carcinoma, the drug Axitinib targets the genes KDR, FLT1, and FLT4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%axitinib%" OR LOWER(tradeNames_list) LIKE "%axiti... | [{'UUID': 'DrugTargetsIndication121923_text_689364', 'drugName': 'Axitinib', 'tradeNames_list': "['Inlyta']", 'syns_list': "['AG-013736', 'AG-13736', 'Axitinib', 'NSC-757441']", 'target': 'ENSG00000128052', 'approvedSymbol': 'KDR', 'approvedName': 'kinase insert domain receptor', 'mesh_heading': 'Carcinoma, Renal Cell'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.747 | Q6 | What genes does Pantoprazole Sodium target when it's used to treat Esophagitis? | When used to treat Esophagitis, the drug Pantoprazole Sodium targets the genes ATP4A and ATP4B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%pantoprazole sodium%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_1097771', 'drugName': 'Pantoprazole Sodium', 'tradeNames_list': "['Pantoprazole sodium', 'Protonix', 'Protonix iv']", 'syns_list': "['Controloc control', 'Pantoprazole (as sodium)', 'Pantoprazole sodiumPantoprazole sodium hydrate', 'Pantoprazole sodium sesquihydratePantozol c... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1691 | Q6 | What genes does Aspirin target when it's used to treat prostate adenocarcinoma? | Aspirin has not been approved by the FDA as a treatment for prostate adenocarcinoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%aspirin%" OR LOWER(tradeNames_list) LIKE "%aspiri... | [{'UUID': 'DrugTargetsIndication121923_text_834317', 'drugName': 'Aspirin', 'tradeNames_list': "['8-hour bayer', 'Acetosalic Acid', 'Acetylsalic acidAcetylsalicylic Acid', 'Alka rapid', 'Anadin all night', 'Angettes 75Aspirin', 'Aspro clr', 'Bayer extra strength aspirin for migraine painDanamep', 'Disprin cv', 'Disprin... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1090 | Q6 | What genes does Ixazomib Citrate target when it's used to treat multiple myeloma? | When used to treat multiple myeloma, the drug Ixazomib Citrate targets the genes PSMD1, PSMB2, PSMB1, PSMB5, PSMB8, PSMB9, PSMB6, PSMD14, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB10, PSMB11, PSMB3, PSMB4, PSMB7, ADRM1, PSMC2, PSMC1, PSMC4, PSMC6, PSMC3, PSMC5, PSMD2, PSMD3, PSMD12, PSMD11, PSMD6, PSM... | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ixazomib citrate%" OR LOWER(tradeNames_list) LIKE... | [{'UUID': 'DrugTargetsIndication121923_text_326447', 'drugName': 'Ixazomib Citrate', 'tradeNames_list': "['Ninlaro']", 'syns_list': "['Ixazomib citrate', 'MLN-9708', 'MLN9708']", 'target': 'ENSG00000173692', 'approvedSymbol': 'PSMD1', 'approvedName': 'proteasome 26S subunit, non-ATPase 1', 'mesh_heading': 'Multiple Mye... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.837 | Q6 | What genes does Cetirizine Hydrochloride target when it's used to treat seasonal allergic rhinitis? | When used to treat seasonal allergic rhinitis, the drug Cetirizine Hydrochloride targets the gene HRH1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%cetirizine hydrochloride%" OR LOWER(tradeNames_li... | [{'UUID': 'DrugTargetsIndication121923_text_455819', 'drugName': 'Cetirizine Hydrochloride', 'tradeNames_list': '[\'Allacan\', \'Allertek\', \'Becoallergy\', \'Cetec\', \'Cetirizine hydrochlorideCetirizine hydrochloride allergy\', \'Cetirizine hydrochloride hivesCetirizine hydrochloride hives relief\', "CetirocolChildr... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.122 | Q6 | What genes does Fluticasone Propionate target when it's used to treat skin disease? | When used to treat skin disease, the drug Fluticasone Propionate targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%fluticasone propionate%" OR LOWER(tradeNames_list... | [{'UUID': 'DrugTargetsIndication121923_text_232531', 'drugName': 'Fluticasone Propionate', 'tradeNames_list': "['Aerivio spiromax', 'Airflusal forspiro', 'Armonair digihalerArmonair respiclick', 'Cutivate', 'Flixonase', 'Flixotide', 'FlonaseFlonase allergy relief', 'Flovent', 'Flovent diskus 100Flovent diskus 250', 'Fl... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.663 | Q6 | What genes does Esomeprazole Magnesium target when it's used to treat ankylosing spondylitis? | When used to treat ankylosing spondylitis, the drug Esomeprazole Magnesium targets the genes ATP4A and ATP4B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%esomeprazole magnesium%" OR LOWER(tradeNames_list... | [{'UUID': 'DrugTargetsIndication121923_text_1097872', 'drugName': 'Esomeprazole Magnesium', 'tradeNames_list': "['Esomeprazole magnesium', 'Nexium', 'Nexium 24hr']", 'syns_list': "['Esomeprazole (as magnesium)', 'Esomeprazole magnesiumEsomeprazole magnesium hydrate', 'Esomeprazole magnesium trihydrateH199/18 MAGNESIUM ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1908 | Q6 | What genes does Ribociclib Succinate target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Ribociclib Succinate targets the genes CDK4 and CDK6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ribociclib succinate%" OR LOWER(tradeNames_list) ... | [{'UUID': 'DrugTargetsIndication121923_text_848933', 'drugName': 'Ribociclib Succinate', 'tradeNames_list': "['Kisqali']", 'syns_list': "['Birociclib', 'LEE-011-BBA', 'LEE011-BBA', 'Ribociclib succinate']", 'target': 'ENSG00000135446', 'approvedSymbol': 'CDK4', 'approvedName': 'cyclin dependent kinase 4', 'mesh_heading... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.642 | Q6 | What genes does Celecoxib target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Celecoxib targets the gene PTGS2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%celecoxib%" OR LOWER(tradeNames_list) LIKE "%cele... | [{'UUID': 'DrugTargetsIndication121923_text_833160', 'drugName': 'Celecoxib', 'tradeNames_list': "['Celebra', 'Celebrex', 'Celecoxib', 'Elyxyb', 'Onsenal']", 'syns_list': "['Celecoxib', 'DFN-15', 'DFN15', 'NSC-719627', 'NSC-758624', 'SC-58635']", 'target': 'ENSG00000073756', 'approvedSymbol': 'PTGS2', 'approvedName': '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.374 | Q6 | What genes does Fentanyl Citrate target when it's used to treat interstitial lung disease? | Fentanyl Citrate has not been approved by the FDA as a treatment for interstitial lung disease, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is OPRM1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%fentanyl citrate%" OR LOWER(tradeNames_list) LIKE... | [{'UUID': 'DrugTargetsIndication121923_text_785352', 'drugName': 'Fentanyl Citrate', 'tradeNames_list': "['Abstral', 'Actiq', 'Fentanyl', 'Fentanyl citrateFentanyl citrate preservative free', 'Fentora', 'Lazanda', 'OnsolisSublimaze', 'Sublimaze preservative free', 'Thalamonal']", 'syns_list': "['Fentanyl buccal', 'Fent... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.271 | Q6 | What genes does Diclofenac target when it's used to treat sprain? | When used to treat sprain, the drug Diclofenac targets the genes PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%diclofenac%" OR LOWER(tradeNames_list) LIKE "%dic... | [{'UUID': 'DrugTargetsIndication121923_text_837522', 'drugName': 'Diclofenac', 'tradeNames_list': "['Cambia', 'Voltaren', 'Voltaren Ophthalmic', 'Voltaren Xr', 'ZorvolexZorvolex capsules']", 'syns_list': "['Arthrotec', 'Cataflam', 'Diclofenac', 'Diclofenac acidDiclofenac free acid', 'LAS-41007', 'LAS41007', 'Las41007',... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.662 | Q6 | What genes does Hydrocortisone Butyrate target when it's used to treat skin disease? | When used to treat skin disease, the drug Hydrocortisone Butyrate targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%hydrocortisone butyrate%" OR LOWER(tradeNames_lis... | [{'UUID': 'DrugTargetsIndication121923_text_243802', 'drugName': 'Hydrocortisone Butyrate', 'tradeNames_list': "['Hydrocortisone butyrate', 'Locoid', 'Locoid c', 'Locoid creloLocoid lipocream']", 'syns_list': "['Cortisol 17-butyrate', 'Hydrocortisone 17-butyrateHydrocortisone butyrate', 'Hydrocortisone-17-butyrate', 'N... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.944 | Q6 | What genes does Alpelisib target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Alpelisib targets the gene PIK3CA. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%alpelisib%" OR LOWER(tradeNames_list) LIKE "%alpe... | [{'UUID': 'DrugTargetsIndication121923_text_939608', 'drugName': 'Alpelisib', 'tradeNames_list': "['Piqray', 'Vijoice']", 'syns_list': "['Alpelisib', 'BYL-719', 'BYL719', 'Byl-719', 'NVP-BYL719', 'Vijoice']", 'target': 'ENSG00000121879', 'approvedSymbol': 'PIK3CA', 'approvedName': 'phosphatidylinositol-4,5-bisphosphate... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.829 | Q6 | What genes does Midazolam target when it's used to treat status epilepticus? | When used to treat status epilepticus, the drug Midazolam targets the genes GABRA1, GABRB2, GABRG2, GABRB3, GABRA4, GABRG3, GABRQ, GABRA3, GABRP, GABRD, GABRG1, GABRB1, GABRE, GABRA2, GABRA5, and GABRA6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%midazolam%" OR LOWER(tradeNames_list) LIKE "%mida... | [{'UUID': 'DrugTargetsIndication121923_text_949055', 'drugName': 'Midazolam', 'tradeNames_list': "['Midazolam in 0.8% sodium chloride', 'Midazolam in 0.9% sodium chlorideNayzilam']", 'syns_list': "['Midazolam', 'Midazolam civ', 'USL-261', 'USL261']", 'target': 'ENSG00000022355', 'approvedSymbol': 'GABRA1', 'approvedNam... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.873 | Q6 | What genes does Panobinostat target when it's used to treat glioblastoma multiforme? | Panobinostat has not been approved by the FDA as a treatment for glioblastoma multiforme, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are HDAC1, HDAC3, HDAC6, HDAC2, HDAC5, HDAC7, HDAC8, HDAC11, HDAC4, HDAC9, and HDAC10. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%panobinostat%" OR LOWER(tradeNames_list) LIKE "%p... | [{'UUID': 'DrugTargetsIndication121923_text_1080914', 'drugName': 'Panobinostat', 'tradeNames_list': "['Farydak']", 'syns_list': "['LBH-589', 'LBH589', 'Panobinostat', 'Panobinostat hydrate']", 'target': 'ENSG00000116478', 'approvedSymbol': 'HDAC1', 'approvedName': 'histone deacetylase 1', 'mesh_heading': 'Glioblastoma... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.47 | Q6 | What genes does Desonide target when it's used to treat atopic eczema? | When used to treat atopic eczema, the drug Desonide targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%desonide%" OR LOWER(tradeNames_list) LIKE "%deson... | [{'UUID': 'DrugTargetsIndication121923_text_217428', 'drugName': 'Desonide', 'tradeNames_list': "['Desonate', 'Desonide', 'Desowen', 'Tridesilon', 'Verdeso']", 'syns_list': "['D-2083', 'D2083', 'Desonate', 'Desonide', 'NSC-759226']", 'target': 'ENSG00000113580', 'approvedSymbol': 'NR3C1', 'approvedName': 'nuclear recep... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1388 | Q6 | What genes does Tivozanib Hydrochloride target when it's used to treat renal cell carcinoma? | When used to treat renal cell carcinoma, the drug Tivozanib Hydrochloride targets the genes KDR, FLT1, KIT, FLT4, and PDGFRB. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%tivozanib hydrochloride%" OR LOWER(tradeNames_lis... | [{'UUID': 'DrugTargetsIndication121923_text_682894', 'drugName': 'Tivozanib Hydrochloride', 'tradeNames_list': "['Fotivda']", 'syns_list': "['AV-951', 'Tivozanib hydrochloride', 'Tivozanib hydrochloride monohydrate']", 'target': 'ENSG00000102755', 'approvedSymbol': 'FLT1', 'approvedName': 'fms related receptor tyrosine... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1709 | Q6 | What genes does Everolimus target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Everolimus targets the gene FKBP1A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%everolimus%" OR LOWER(tradeNames_list) LIKE "%eve... | [{'UUID': 'DrugTargetsIndication121923_text_1085633', 'drugName': 'Everolimus', 'tradeNames_list': "['Afinitor', 'Afinitor disperz', 'Certican', 'Votubia', 'Zortress']", 'syns_list': "['40-o-(2-hydroxyethyl)-rapamycin', 'Everolimus', 'RAD 666', 'RAD-001RAD-666', 'RAD001', 'SDZ-RAD', 'Sdz rad']", 'target': 'ENSG00000088... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1000 | Q6 | What genes does Zoledronic Acid target when it's used to treat bone metastasis? | When used to treat bone metastasis, the drug Zoledronic Acid targets the gene FDPS. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%zoledronic acid%" OR LOWER(tradeNames_list) LIKE ... | [{'UUID': 'DrugTargetsIndication121923_text_1099882', 'drugName': 'Zoledronic Acid', 'tradeNames_list': "['Aclasta', 'Reclast', 'Zerlinda', 'Zoledronic acid', 'Zometa']", 'syns_list': "['AK-156', 'Anhydrous zoledronic acid', 'CGP 42446', 'CGP-42446', 'CGP-42446ANSC-721517', 'Zoladrona acid mylan', 'Zoledronate', 'Zoled... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.883 | Q6 | What genes does Donepezil Hydrochloride target when it's used to treat migraine disorder? | Donepezil Hydrochloride has not been approved by the FDA as a treatment for migraine disorder, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is ACHE. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%donepezil hydrochloride%" OR LOWER(tradeNames_lis... | [{'UUID': 'DrugTargetsIndication121923_text_993841', 'drugName': 'Donepezil Hydrochloride', 'tradeNames_list': "['Adlarity', 'Aricept', 'Aricept evess', 'Aricept odtDonepezil hydrochloride']", 'syns_list': "['Adlarity', 'BNAG', 'Donepezil hcl', 'Donepezil hydrochloride', 'E-2020E2020', 'NSC-737535', 'NSC-758882']", 'ta... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.780 | Q6 | What genes does Calcifediol target when it's used to treat secondary hyperparathyroidism? | When used to treat secondary hyperparathyroidism, the drug Calcifediol targets the gene VDR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%calcifediol%" OR LOWER(tradeNames_list) LIKE "%ca... | [{'UUID': 'DrugTargetsIndication121923_text_823428', 'drugName': 'Calcifediol', 'tradeNames_list': "['Calderol', 'Rayaldee']", 'syns_list': "['CTAP101', 'Calcidiol', 'Calcifediol', 'Calcifediol hydrate', 'Ctap-101Didrogyl', 'Hidroferol', 'Rayaldy', 'U-32,070E', 'U-32070E']", 'target': 'ENSG00000111424', 'approvedSymbol... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1229 | Q6 | What genes does Methotrexate target when it's used to treat lung cancer? | When used to treat lung cancer, the drug Methotrexate targets the gene DHFR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%methotrexate%" OR LOWER(tradeNames_list) LIKE "%m... | [{'UUID': 'DrugTargetsIndication121923_text_1057602', 'drugName': 'Methotrexate', 'tradeNames_list': "['Amethopterin', 'Ebetrex', 'Emtexate high-pot', 'Emtexate pf', 'FolexMaxtrex', 'Methotrexate', 'Metoject', 'Mexate', 'Otrexup', 'Otrexup pfsRasuvo', 'Reditrex', 'Rheumatrex', 'Trexall', 'Zlatal']", 'syns_list': "['(r)... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.2000 | Q6 | What genes does Olopatadine Hydrochloride target when it's used to treat seasonal allergic rhinitis? | When used to treat seasonal allergic rhinitis, the drug Olopatadine Hydrochloride targets the gene HRH1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%olopatadine hydrochloride%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_455973', 'drugName': 'Olopatadine Hydrochloride', 'tradeNames_list': "['Olopatadine hydrochloride', 'Pataday', 'Pataday once daily reliefPataday twice daily relief', 'Patanase', 'Patanol', 'Pazeo']", 'syns_list': "['ALO-4943A', 'ALO4943A', 'Allelock', 'KW-4679', 'KW4679Olopat... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.5 | Q6 | What genes does Abiraterone Acetate target when it's used to treat prostate adenocarcinoma? | When used to treat prostate adenocarcinoma, the drug Abiraterone Acetate targets the gene CYP17A1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%abiraterone acetate%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_1094286', 'drugName': 'Abiraterone Acetate', 'tradeNames_list': "['Yonsa', 'Zytiga']", 'syns_list': "['Abiraterone acetate', 'CB-7630', 'CB7630', 'NSC-748121', 'NSC-749227']", 'target': 'ENSG00000148795', 'approvedSymbol': 'CYP17A1', 'approvedName': 'cytochrome P450 family 17... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
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