uuid stringlengths 4 8 | template_uuid stringclasses 40
values | question stringlengths 13 193 | answer stringlengths 29 2.2k | benchmark_query stringlengths 133 622 | execution_results stringlengths 2 1.14M | query_type stringclasses 2
values | sql_category stringclasses 26
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Q6.107 | Q6 | What genes does Ephedrine Sulfate target when it's used to treat seasonal allergic rhinitis? | When used to treat seasonal allergic rhinitis, the drug Ephedrine Sulfate targets the genes ADRA1A, ADRB2, ADRB1, ADRB3, ADRA1D, ADRA1B, ADRA2A, ADRA2C, and ADRA2B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ephedrine sulfate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_418286', 'drugName': 'Ephedrine Sulfate', 'tradeNames_list': "['Akovaz', 'Corphedra', 'Emerphed', 'Expansyl', 'Franol plus', 'Franol-plusIsofedrol']", 'syns_list': "['Ephedrine sulfate', 'Ephedrine sulphate', 'Ephedrini sulfas']", 'target': 'ENSG00000043591', 'approvedSymbol'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.695 | Q6 | What genes does Ciclesonide target when it's used to treat Rhinitis, Allergic, Perennial? | When used to treat Rhinitis, Allergic, Perennial, the drug Ciclesonide targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ciclesonide%" OR LOWER(tradeNames_list) LIKE "%ci... | [{'UUID': 'DrugTargetsIndication121923_text_217455', 'drugName': 'Ciclesonide', 'tradeNames_list': "['Alvesco', 'Alvesco 160', 'Alvesco 80', 'Omnaris', 'Zetonna']", 'syns_list': "['BI54903', 'Ciclesonide', 'RPR-251526', 'RPR251526']", 'target': 'ENSG00000113580', 'approvedSymbol': 'NR3C1', 'approvedName': 'nuclear rece... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1305 | Q6 | What genes does Imiquimod target when it's used to treat viral disease? | When used to treat viral disease, the drug Imiquimod targets the gene TLR7. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%imiquimod%" OR LOWER(tradeNames_list) LIKE "%imiq... | [{'UUID': 'DrugTargetsIndication121923_text_919778', 'drugName': 'Imiquimod', 'tradeNames_list': "['Aldara', 'Imiquimod', 'Zyclara']", 'syns_list': "['Aldara', 'Imiquimod', 'NSC-369100', 'NSC-759651', 'R-837', 'S-26308', 'S26308Tmx-101']", 'target': 'ENSG00000196664', 'approvedSymbol': 'TLR7', 'approvedName': 'toll lik... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.833 | Q6 | What genes does Docetaxel target when it's used to treat cancer? | When used to treat cancer, the drug Docetaxel targets the genes TUBB4B, TUBB1, TUBA3C, TUBA4A, TUBB3, TUBA1A, TUBB4A, TUBB8, TUBB, TUBA1B, TUBA1C, TUBA3E, TUBB2A, TUBB2B, and TUBB6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%docetaxel%" OR LOWER(tradeNames_list) LIKE "%doce... | [{'UUID': 'DrugTargetsIndication121923_text_99470', 'drugName': 'Docetaxel', 'tradeNames_list': "['Docefrez', 'Docetaxel', 'Taxceus', 'Taxotere']", 'syns_list': "['Bind 014', 'CKD-810', 'Docetaxel', 'Docetaxel (as trihydrate)Docetaxel anhydrous', 'Docetaxel hydrate', 'Docetaxel trihydrateNSC-628503', 'RP 56976', 'RP-56... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.64 | Q6 | What genes does Desoximetasone target when it's used to treat psoriasis vulgaris? | When used to treat psoriasis vulgaris, the drug Desoximetasone targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%desoximetasone%" OR LOWER(tradeNames_list) LIKE "... | [{'UUID': 'DrugTargetsIndication121923_text_220822', 'drugName': 'Desoximetasone', 'tradeNames_list': "['Desoximetasone', 'Stiedex', 'Stiedex lp', 'Stiedex lpn', 'TopicortTopicort lp']", 'syns_list': "['A-41-304', 'A-41304', 'Desoximetasone', 'Desoxymethasone', 'HOE 304HOE-304', 'J83.644C', 'NSC-759189', 'R 2113', 'R-2... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.859 | Q6 | What genes does Imatinib Mesylate target when it's used to treat chronic myelogenous leukemia? | When used to treat chronic myelogenous leukemia, the drug Imatinib Mesylate targets the genes ABL1, BCR, KIT, and PDGFRB. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%imatinib mesylate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_743542', 'drugName': 'Imatinib Mesylate', 'tradeNames_list': "['Gleevec', 'Glivec', 'Imatinib mesylate']", 'syns_list': "['Gleevec', 'Imatinib (as mesilate)', 'Imatinib accord', 'Imatinib medacImatinib mesilate', 'Imatinib mesylate', 'Imatinib methane sulfonateImatinib methan... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1355 | Q6 | What genes does Temsirolimus target when it's used to treat clear cell renal carcinoma? | When used to treat clear cell renal carcinoma, the drug Temsirolimus targets the gene FKBP1A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%temsirolimus%" OR LOWER(tradeNames_list) LIKE "%t... | [{'UUID': 'DrugTargetsIndication121923_text_1091088', 'drugName': 'Temsirolimus', 'tradeNames_list': "['Torisel']", 'syns_list': "['CCI-779', 'Temsirolimus']", 'target': 'ENSG00000088832', 'approvedSymbol': 'FKBP1A', 'approvedName': 'FKBP prolyl isomerase 1A', 'mesh_heading': 'Carcinoma, Renal Cell', 'efo_term': 'clear... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.226 | Q6 | What genes does Fesoterodine Fumarate target when it's used to treat Urinary incontinence? | Fesoterodine Fumarate has not been approved by the FDA as a treatment for Urinary incontinence, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are CHRM3 and CHRM2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%fesoterodine fumarate%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_857374', 'drugName': 'Fesoterodine Fumarate', 'tradeNames_list': "['Fesoterodine fumarate', 'Toviaz']", 'syns_list': "['Fesoterodine fumarate', 'SPM 8272', 'SPM 907', 'SPM-8272', 'SPM-907']", 'target': 'ENSG00000181072', 'approvedSymbol': 'CHRM2', 'approvedName': 'cholinergic... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.148 | Q6 | What genes does Epinephrine target when it's used to treat sinusitis? | When used to treat sinusitis, the drug Epinephrine targets the genes ADRA1A, ADRB2, ADRB1, ADRB3, ADRA1D, ADRA1B, ADRA2A, ADRA2C, and ADRA2B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%epinephrine%" OR LOWER(tradeNames_list) LIKE "%ep... | [{'UUID': 'DrugTargetsIndication121923_text_361096', 'drugName': 'Epinephrine', 'tradeNames_list': "['Adren co', 'Adrenaclick', 'Adrenalin', 'Ana-Kit', 'Ana-guard', 'AnapenAnaphylactic shock drug kit', 'Asma-vydrin', 'Asthmahaler', 'Auvi-qBronkaid mist', 'Brovon', 'Emerade', 'Epi e z pen jr', 'EpinephrineEpinephrine (c... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1097 | Q6 | What genes does Midostaurin target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Midostaurin targets the genes KDR, FLT3, KIT, PDGFRB, PDGFRA, PRKCE, PRKCB, PRKD3, PRKCI, PRKCA, PRKCG, PRKCD, PRKCZ, PRKCH, PRKD1, and PRKCQ. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%midostaurin%" OR LOWER(tradeNames_list) LIKE "%mi... | [{'UUID': 'DrugTargetsIndication121923_text_667533', 'drugName': 'Midostaurin', 'tradeNames_list': "['Rydapt']", 'syns_list': "['CGP 41251', 'CGP-41251', 'Midostaurin', 'NSC-656576', 'NVP-PKC412', 'PKC 412PKC-412', 'Pkc-412']", 'target': 'ENSG00000115825', 'approvedSymbol': 'PRKD3', 'approvedName': 'protein kinase D3',... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.379 | Q6 | What genes does Beclomethasone Dipropionate target when it's used to treat graft versus host disease? | Beclomethasone Dipropionate has not been approved by the FDA as a treatment for graft versus host disease, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%beclomethasone dipropionate%" OR LOWER(tradeNames... | [{'UUID': 'DrugTargetsIndication121923_text_221039', 'drugName': 'Beclomethasone Dipropionate', 'tradeNames_list': "['Aerobec 100', 'Aerobec 50', 'Aerobec fte 250', 'Asmabec clickhalerAsmabec spacehaler', 'Beclazone 100', 'Beclazone 100 e-breatheBeclazone 200', 'Beclazone 250', 'Beclazone 250 e-breathe', 'Beclazone 50B... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1422 | Q6 | What genes does Olodaterol Hydrochloride target when it's used to treat emphysema? | When used to treat emphysema, the drug Olodaterol Hydrochloride targets the gene ADRB2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%olodaterol hydrochloride%" OR LOWER(tradeNames_li... | [{'UUID': 'DrugTargetsIndication121923_text_937111', 'drugName': 'Olodaterol Hydrochloride', 'tradeNames_list': "['Striverdi respimat']", 'syns_list': "['BI 1744 CL', 'BI-1744 CL', 'BI-1744-CL', 'Olodaterol hydrochloride']", 'target': 'ENSG00000169252', 'approvedSymbol': 'ADRB2', 'approvedName': 'adrenoceptor beta 2', ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1152 | Q6 | What genes does Megestrol Acetate target when it's used to treat AIDS? | When used to treat AIDS, the drug Megestrol Acetate targets the gene PGR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%megestrol acetate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_940578', 'drugName': 'Megestrol Acetate', 'tradeNames_list': "['Megace', 'Megace es', 'Megestrol acetate', 'Ovaban']", 'syns_list': "['5071', 'BDH 1298', 'BDH-1298', 'Chronopil', 'Megesterol acetate', 'MegestrolMegestrol 17.alpha.-acetate', 'Megestrol acetate', 'NSC-71423', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1828 | Q6 | What genes does Thalidomide target when it's used to treat Beta-thalassemia? | Thalidomide has not been approved by the FDA as a treatment for Beta-thalassemia, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are CRBN, DDB1, CUL4A, and RBX1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%thalidomide%" OR LOWER(tradeNames_list) LIKE "%th... | [{'UUID': 'DrugTargetsIndication121923_text_1105090', 'drugName': 'Thalidomide', 'tradeNames_list': "['Talidex', 'Thalomid']", 'syns_list': "['.alpha.-phthalimidoglutarimide', 'Celgene', 'Contergan', 'Distaval', 'K-17Myrin', 'N-phthalylglutamic acid imide', 'NSC-527179', 'NSC-66847Neurosedyn', 'Pantosediv', 'Pharmion',... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1496 | Q6 | What genes does Selexipag target when it's used to treat idiopathic and/or familial pulmonary arterial hypertension? | When used to treat idiopathic and/or familial pulmonary arterial hypertension, the drug Selexipag targets the gene PTGIR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%selexipag%" OR LOWER(tradeNames_list) LIKE "%sele... | [{'UUID': 'DrugTargetsIndication121923_text_246145', 'drugName': 'Selexipag', 'tradeNames_list': "['Uptravi']", 'syns_list': "['ACT-293987', 'NS-304', 'Selexipag']", 'target': 'ENSG00000160013', 'approvedSymbol': 'PTGIR', 'approvedName': 'prostaglandin I2 receptor', 'mesh_heading': 'Familial Primary Pulmonary Hypertens... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1602 | Q6 | What genes does Topiramate target when it's used to treat migraine disorder? | When used to treat migraine disorder, the drug Topiramate targets the genes SCN1A, SCN5A, SCN4A, SCN7A, SCN2A, SCN9A, SCN3A, SCN11A, SCN8A, SCN10A, CA2, CA4, GABRA1, GABRB2, GABRG2, GABRB3, GABRA4, GABRG3, GABRQ, GABRA3, GABRP, GABRD, GABRG1, GABRB1, GABRE, GABRA2, GABRA5, GABRA6, GRIK1, GRIK5, GRIK4, GRIK2, GRIK3, GRI... | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%topiramate%" OR LOWER(tradeNames_list) LIKE "%top... | [{'UUID': 'DrugTargetsIndication121923_text_457464', 'drugName': 'Topiramate', 'tradeNames_list': "['Epitomax', 'Eprontia', 'Qudexy xr', 'Topamax', 'Topamax sprinkleTopiramate', 'Trokendi xr']", 'syns_list': "['(-)-topiramate', 'Epitoma', 'Eprontia', 'MCN-4853', 'Qudexy', 'RWJ-17021RWJ-17021-000', 'Sincronil', 'Topamac... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1759 | Q6 | What genes does Celecoxib target when it's used to treat melanoma? | Celecoxib has not been approved by the FDA as a treatment for melanoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is PTGS2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%celecoxib%" OR LOWER(tradeNames_list) LIKE "%cele... | [{'UUID': 'DrugTargetsIndication121923_text_833420', 'drugName': 'Celecoxib', 'tradeNames_list': "['Celebra', 'Celebrex', 'Celecoxib', 'Elyxyb', 'Onsenal']", 'syns_list': "['Celecoxib', 'DFN-15', 'DFN15', 'NSC-719627', 'NSC-758624', 'SC-58635']", 'target': 'ENSG00000073756', 'approvedSymbol': 'PTGS2', 'approvedName': '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.10 | Q6 | What genes does Enalapril Maleate target when it's used to treat hypertension? | When used to treat hypertension, the drug Enalapril Maleate targets the gene ACE. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%enalapril maleate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_1091900', 'drugName': 'Enalapril Maleate', 'tradeNames_list': "['Ednyt', 'Enalapril maleate', 'Enapren', 'Epaned', 'Epaned kit', 'InnovacePralenal 10', 'Pralenal 2.5', 'Pralenal 20', 'Pralenal 5', 'RenitecVasotec', 'Xanef']", 'syns_list': "['Enalapril maleate', 'MK-421', 'NSC... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.455 | Q6 | What genes does Nintedanib target when it's used to treat prostate adenocarcinoma? | Nintedanib has not been approved by the FDA as a treatment for prostate adenocarcinoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are KDR, FGFR1, FGFR3, FGFR2, FLT1, FLT4, PDGFRB, PDGFRA, and FGFR4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%nintedanib%" OR LOWER(tradeNames_list) LIKE "%nin... | [{'UUID': 'DrugTargetsIndication121923_text_678894', 'drugName': 'Nintedanib', 'tradeNames_list': "['Ofev', 'Vargatef']", 'syns_list': "['BIBF 1120', 'BIBF-1120', 'BIBF1120', 'Bibf-1120', 'Intedanib', 'Nintedanib']", 'target': 'ENSG00000128052', 'approvedSymbol': 'KDR', 'approvedName': 'kinase insert domain receptor', ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.715 | Q6 | What genes does Cinacalcet Hydrochloride target when it's used to treat secondary hyperparathyroidism? | When used to treat secondary hyperparathyroidism, the drug Cinacalcet Hydrochloride targets the gene CASR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%cinacalcet hydrochloride%" OR LOWER(tradeNames_li... | [{'UUID': 'DrugTargetsIndication121923_text_1149037', 'drugName': 'Cinacalcet Hydrochloride', 'tradeNames_list': "['Mimpara', 'Sensipar']", 'syns_list': "['AMG-073', 'AMG-073 HCL', 'AMG073 HCL', 'AMG073 HYDROCHLORIDECinacalcet hcl', 'Cinacalcet hydrochloride']", 'target': 'ENSG00000036828', 'approvedSymbol': 'CASR', 'a... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.258 | Q6 | What genes does Paclitaxel target when it's used to treat non-small cell lung carcinoma? | When used to treat non-small cell lung carcinoma, the drug Paclitaxel targets the genes TUBB4B, TUBB1, TUBA3C, TUBA4A, TUBB3, TUBA1A, TUBB4A, TUBB8, TUBB, TUBA1B, TUBA1C, TUBA3E, TUBB2A, TUBB2B, and TUBB6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%paclitaxel%" OR LOWER(tradeNames_list) LIKE "%pac... | [{'UUID': 'DrugTargetsIndication121923_text_933', 'drugName': 'Paclitaxel', 'tradeNames_list': "['Abraxane', 'Pacitaxel', 'Paclitaxel', 'Paxene', 'Taxol', 'Taxol 100']", 'syns_list': "['(-)-paclitaxel', 'ABI-007', 'ABI-007 COMPONENT PACLITAXEL', 'BMS 181339-01BMS-181339-01', 'Capxol', 'Cyclopax', 'DHP 107', 'DHP-107', ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.889 | Q6 | What genes does Sonidegib Phosphate target when it's used to treat basal cell carcinoma? | When used to treat basal cell carcinoma, the drug Sonidegib Phosphate targets the gene SMO. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%sonidegib phosphate%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_1072620', 'drugName': 'Sonidegib Phosphate', 'tradeNames_list': "['Odomzo']", 'syns_list': "['Erismodegib phosphate', 'Sonidegib diphosphate', 'Sonidegib phosphate']", 'target': 'ENSG00000128602', 'approvedSymbol': 'SMO', 'approvedName': 'smoothened, frizzled class receptor',... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.395 | Q6 | What genes does Vorinostat target when it's used to treat cancer? | When used to treat cancer, the drug Vorinostat targets the genes HDAC1, HDAC3, HDAC6, and HDAC2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%vorinostat%" OR LOWER(tradeNames_list) LIKE "%vor... | [{'UUID': 'DrugTargetsIndication121923_text_1078457', 'drugName': 'Vorinostat', 'tradeNames_list': "['Zolinza']", 'syns_list': "['MK-0683', 'MK0683', 'NSC-701852', 'NSC-748799', 'NSC-759852Suberoylanilide hydroxamic acid', 'Vorinostat']", 'target': 'ENSG00000094631', 'approvedSymbol': 'HDAC6', 'approvedName': 'histone ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.916 | Q6 | What genes does Propranolol Hydrochloride target when it's used to treat angina pectoris? | When used to treat angina pectoris, the drug Propranolol Hydrochloride targets the genes ADRB2 and ADRB1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%propranolol hydrochloride%" OR LOWER(tradeNames_l... | [{'UUID': 'DrugTargetsIndication121923_text_937042', 'drugName': 'Propranolol Hydrochloride', 'tradeNames_list': "['Angilol', 'Apsolol', 'Avlocardyl', 'Bedranol', 'Bedranol s.r.', 'BerkololBeta-prograne mr', 'Betadur cr', 'Cardinol', 'DupromexHalf beta-prograne mr', 'Half propanix la', 'Half propatard laHalf-beprane cr... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.932 | Q6 | What genes does Vorinostat target when it's used to treat HIV-1 infection? | Vorinostat has not been approved by the FDA as a treatment for HIV-1 infection, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are HDAC1, HDAC3, HDAC6, and HDAC2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%vorinostat%" OR LOWER(tradeNames_list) LIKE "%vor... | [{'UUID': 'DrugTargetsIndication121923_text_1077086', 'drugName': 'Vorinostat', 'tradeNames_list': "['Zolinza']", 'syns_list': "['MK-0683', 'MK0683', 'NSC-701852', 'NSC-748799', 'NSC-759852Suberoylanilide hydroxamic acid', 'Vorinostat']", 'target': 'ENSG00000116478', 'approvedSymbol': 'HDAC1', 'approvedName': 'histone ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1704 | Q6 | What genes does Sodium Oxybate target when it's used to treat narcolepsy? | When used to treat narcolepsy, the drug Sodium Oxybate targets the genes GABBR1 and GABBR2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%sodium oxybate%" OR LOWER(tradeNames_list) LIKE "... | [{'UUID': 'DrugTargetsIndication121923_text_1192730', 'drugName': 'Sodium Oxybate', 'tradeNames_list': "['Xyrem']", 'syns_list': "['.gamma.-hydroxybutyrate sodium salt', 'Catabate', 'Lumryz', 'NSC-84223Oxybate sodium', 'Sodium oxybat', 'Sodium oxybate', 'Sodium oxybutyrateWY-3478']", 'target': 'ENSG00000204681', 'appro... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1231 | Q6 | What genes does Bortezomib target when it's used to treat melanoma? | Bortezomib has not been approved by the FDA as a treatment for melanoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are PSMD1, PSMB2, PSMB1, PSMB5, PSMB8, PSMB9, PSMB6, PSMD14, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMA8, PSMB10, PSMB11, PSMB3, PS... | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bortezomib%" OR LOWER(tradeNames_list) LIKE "%bor... | [{'UUID': 'DrugTargetsIndication121923_text_342291', 'drugName': 'Bortezomib', 'tradeNames_list': "['Velcade']", 'syns_list': "['Bortezomib', 'Bortezomib accord', 'Bortezomib hydrate', 'LDP-341NSC-681239', 'PS-341', 'Velcade']", 'target': 'ENSG00000126067', 'approvedSymbol': 'PSMB2', 'approvedName': 'proteasome 20S sub... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.466 | Q6 | What genes does Linaclotide target when it's used to treat Constipation? | When used to treat Constipation, the drug Linaclotide targets the gene GUCY2C. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%linaclotide%" OR LOWER(tradeNames_list) LIKE "%li... | [{'UUID': 'DrugTargetsIndication121923_text_1092097', 'drugName': 'Linaclotide', 'tradeNames_list': "['Constella', 'Linzess']", 'syns_list': "['ASP-0456', 'ASP0456', 'Linaclotide', 'MD-1100']", 'target': 'ENSG00000070019', 'approvedSymbol': 'GUCY2C', 'approvedName': 'guanylate cyclase 2C', 'mesh_heading': 'Constipation... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1967 | Q6 | What genes does Lubiprostone target when it's used to treat Constipation? | When used to treat Constipation, the drug Lubiprostone targets the gene CLCN2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lubiprostone%" OR LOWER(tradeNames_list) LIKE "%l... | [{'UUID': 'DrugTargetsIndication121923_text_1193397', 'drugName': 'Lubiprostone', 'tradeNames_list': "['Amitiza']", 'syns_list': "['Lubiprostone', 'RU-0211']", 'target': 'ENSG00000114859', 'approvedSymbol': 'CLCN2', 'approvedName': 'chloride voltage-gated channel 2', 'mesh_heading': 'Constipation', 'efo_term': 'constip... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1178 | Q6 | What genes does Topotecan Hydrochloride target when it's used to treat malignant epithelial tumor of ovary? | When used to treat malignant epithelial tumor of ovary, the drug Topotecan Hydrochloride targets the gene TOP1MT. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%topotecan hydrochloride%" OR LOWER(tradeNames_lis... | [{'UUID': 'DrugTargetsIndication121923_text_1193579', 'drugName': 'Topotecan Hydrochloride', 'tradeNames_list': "['Hycamptin', 'Hycamtin', 'Topotecan', 'Topotecan hydrochloride']", 'syns_list': "['Evotopin', 'NSC-759263', 'Nogitecan hydrochloride', 'SK&F S-104864-ASK&F-S-104864A', 'SK-S-104864-A', 'Topotecan (as hydroc... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.967 | Q6 | What genes does Esomeprazole Magnesium target when it's used to treat Zollinger-Ellison Syndrome? | When used to treat Zollinger-Ellison Syndrome, the drug Esomeprazole Magnesium targets the genes ATP4A and ATP4B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%esomeprazole magnesium%" OR LOWER(tradeNames_list... | [{'UUID': 'DrugTargetsIndication121923_text_1097875', 'drugName': 'Esomeprazole Magnesium', 'tradeNames_list': "['Esomeprazole magnesium', 'Nexium', 'Nexium 24hr']", 'syns_list': "['Esomeprazole (as magnesium)', 'Esomeprazole magnesiumEsomeprazole magnesium hydrate', 'Esomeprazole magnesium trihydrateH199/18 MAGNESIUM ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.507 | Q6 | What genes does Viltolarsen target when it's used to treat muscular dystrophy? | When used to treat muscular dystrophy, the drug Viltolarsen targets the gene DMD. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%viltolarsen%" OR LOWER(tradeNames_list) LIKE "%vi... | [{'UUID': 'DrugTargetsIndication121923_text_1100429', 'drugName': 'Viltolarsen', 'tradeNames_list': "['Viltepso']", 'syns_list': "['NCNP-01', 'NS-065', 'NS-065/NCNP-01', 'Ns-065/ncnp-01', 'Viltolarsen']", 'target': 'ENSG00000198947', 'approvedSymbol': 'DMD', 'approvedName': 'dystrophin', 'mesh_heading': 'Muscular Dystr... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.746 | Q6 | What genes does Ibandronate Sodium target when it's used to treat osteoporosis? | When used to treat osteoporosis, the drug Ibandronate Sodium targets the gene FDPS. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ibandronate sodium%" OR LOWER(tradeNames_list) LI... | [{'UUID': 'DrugTargetsIndication121923_text_1099485', 'drugName': 'Ibandronate Sodium', 'tradeNames_list': "['Boniva', 'Ibandronate sodium']", 'syns_list': "['BM 21.0955 NA H20', 'BM-21.0955', 'BM-210955Ibandronate monosodium monohydrate', 'Ibandronate sodiumIbandronate sodium hydrate', 'Ibandronate sodium monohydrateI... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1851 | Q6 | What genes does Paclitaxel target when it's used to treat cancer? | When used to treat cancer, the drug Paclitaxel targets the genes TUBB4B, TUBB1, TUBA3C, TUBA4A, TUBB3, TUBA1A, TUBB4A, TUBB8, TUBB, TUBA1B, TUBA1C, TUBA3E, TUBB2A, TUBB2B, and TUBB6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%paclitaxel%" OR LOWER(tradeNames_list) LIKE "%pac... | [{'UUID': 'DrugTargetsIndication121923_text_5610', 'drugName': 'Paclitaxel', 'tradeNames_list': "['Abraxane', 'Pacitaxel', 'Paclitaxel', 'Paxene', 'Taxol', 'Taxol 100']", 'syns_list': "['(-)-paclitaxel', 'ABI-007', 'ABI-007 COMPONENT PACLITAXEL', 'BMS 181339-01BMS-181339-01', 'Capxol', 'Cyclopax', 'DHP 107', 'DHP-107',... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.875 | Q6 | What genes does Triamcinolone Acetonide target when it's used to treat Nasal congestion? | When used to treat Nasal congestion, the drug Triamcinolone Acetonide targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%triamcinolone acetonide%" OR LOWER(tradeNames_lis... | [{'UUID': 'DrugTargetsIndication121923_text_222197', 'drugName': 'Triamcinolone Acetonide', 'tradeNames_list': "['Adcortyl', 'Adcortyl in orabase', 'Allernaze', 'Aristocort', 'Aristocort aAristogel', 'Audicort', 'Aureocort', 'Azmacort', 'Flutex', 'Gppe ear dps capGppe ear oint', 'Kenacort', 'Kenalog', 'Kenalog in oraba... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.738 | Q6 | What genes does Apalutamide target when it's used to treat prostate cancer? | When used to treat prostate cancer, the drug Apalutamide targets the gene AR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%apalutamide%" OR LOWER(tradeNames_list) LIKE "%ap... | [{'UUID': 'DrugTargetsIndication121923_text_921863', 'drugName': 'Apalutamide', 'tradeNames_list': "['Erleada']", 'syns_list': "['ARN-509', 'Apalutamide', 'Arn-509', 'JNJ-56021927']", 'target': 'ENSG00000169083', 'approvedSymbol': 'AR', 'approvedName': 'androgen receptor', 'mesh_heading': 'Prostatic Neoplasms', 'efo_te... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.545 | Q6 | What genes does Morphine Sulfate target when it's used to treat cancer? | When used to treat cancer, the drug Morphine Sulfate targets the gene OPRM1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%morphine sulfate%" OR LOWER(tradeNames_list) LIKE... | [{'UUID': 'DrugTargetsIndication121923_text_763496', 'drugName': 'Morphine Sulfate', 'tradeNames_list': "['Arymo er', 'Astramorph pf', 'Avinza', 'Depodur', 'Duramorph', 'Duramorph pfDuromorph', 'Filnarine sr', 'Infumorph', 'Kadian', 'Moraxen', 'Morcap srMorphabond', 'Morphabond er', 'Morphgesic sr', 'Morphine sulfateMo... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1211 | Q6 | What genes does Lifitegrast target when it's used to treat eye disease? | When used to treat eye disease, the drug Lifitegrast targets the genes ITGAL and ITGB2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lifitegrast%" OR LOWER(tradeNames_list) LIKE "%li... | [{'UUID': 'DrugTargetsIndication121923_text_1053375', 'drugName': 'Lifitegrast', 'tradeNames_list': "['Xiidra']", 'syns_list': "['Lifitegrast', 'SAR 1118', 'SAR-1118', 'SHP-606', 'SHP606']", 'target': 'ENSG00000005844', 'approvedSymbol': 'ITGAL', 'approvedName': 'integrin subunit alpha L', 'mesh_heading': 'Eye Diseases... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.704 | Q6 | What genes does Sirolimus target when it's used to treat chronic granulomatous disease? | Sirolimus has not been approved by the FDA as a treatment for chronic granulomatous disease, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is FKBP1A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%sirolimus%" OR LOWER(tradeNames_list) LIKE "%siro... | [{'UUID': 'DrugTargetsIndication121923_text_1084466', 'drugName': 'Sirolimus', 'tradeNames_list': "['Fyarro', 'Hyftor', 'Rapamune', 'Sirolimus']", 'syns_list': "['AY-22989', 'Fyarro', 'Hyftor', 'L04AA10', 'NSC-226080', 'Npc-12g', 'RapalimusRapamycin', 'SM-88 COMPONENT SIROLIMUS', 'Sirolimus', 'WY-090217']", 'target': '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1394 | Q6 | What genes does Dabrafenib Mesylate target when it's used to treat thyroid carcinoma? | When used to treat thyroid carcinoma, the drug Dabrafenib Mesylate targets the gene BRAF. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dabrafenib mesylate%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_752714', 'drugName': 'Dabrafenib Mesylate', 'tradeNames_list': "['Tafinlar']", 'syns_list': "['Dabrafenib mesilate', 'Dabrafenib mesylateGSK-2118436 METHANESULFONATE SALT', 'GSK-2118436BGSK-2118436B MESYLATE', 'GSK-2118436B METHANESULFONATE SALTGSK2118436B', 'GSK2118436B, MET... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1783 | Q6 | What genes does Dimethyl Fumarate target when it's used to treat Cutaneous T-cell lymphoma? | Dimethyl Fumarate has not been approved by the FDA as a treatment for Cutaneous T-cell lymphoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is KEAP1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dimethyl fumarate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_1055748', 'drugName': 'Dimethyl Fumarate', 'tradeNames_list': "['Tecfidera']", 'syns_list': "['AZL 0 211089', 'AZL O 211089', 'AZL-0211089', 'AZL-O-211089', 'BG 00012BG 12', 'BG-00012', 'BG-12', 'BG00012', 'Dimethyl fumar', 'Dimethyl fumarateFAG-201', 'FP-187', 'FP187', 'Fuma... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1155 | Q6 | What genes does Umbralisib Tosylate target when it's used to treat pancreatic carcinoma? | Umbralisib Tosylate has not been approved by the FDA as a treatment for pancreatic carcinoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are ABL1, PIK3CD, and CSNK1E. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%umbralisib tosylate%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_744686', 'drugName': 'Umbralisib Tosylate', 'tradeNames_list': "['Ukoniq']", 'syns_list': "['RP-5307', 'TGR-1202', 'TGR-1202 (4-METHYLBENZENESULFONATE)', 'Tgr-1202Umbralisib tosylate']", 'target': 'ENSG00000097007', 'approvedSymbol': 'ABL1', 'approvedName': 'ABL proto-oncogen... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1040 | Q6 | What genes does Albuterol target when it's used to treat Bronchospasm? | When used to treat Bronchospasm, the drug Albuterol targets the gene ADRB2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%albuterol%" OR LOWER(tradeNames_list) LIKE "%albu... | [{'UUID': 'DrugTargetsIndication121923_text_936282', 'drugName': 'Albuterol Sulfate', 'tradeNames_list': "['Accuneb', 'Albuterol sulfate', 'Proair', 'Proair digihaler', 'Proair hfaProair respiclick', 'Proventil', 'Proventil-hfa', 'Ventolin', 'Ventolin hfaVentolin rotacaps', 'Volmax', 'Vospire er']", 'syns_list': "['Alb... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.378 | Q6 | What genes does Oxybutynin Chloride target when it's used to treat Urinary incontinence? | Oxybutynin Chloride has not been approved by the FDA as a treatment for Urinary incontinence, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are CHRM3 and CHRM2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%oxybutynin chloride%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_857276', 'drugName': 'Oxybutynin Chloride', 'tradeNames_list': "['Ditropan', 'Ditropan xl', 'Gelnique', 'Oxybutynin chloride']", 'syns_list': "['5058', 'MJ 4309-1', 'MJ-4309-1', 'NSC-759108', 'Oxybutynin chlorideOxybutynin hydrochloride', 'Pollakisu', 'Tropax']", 'target': 'E... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.674 | Q6 | What genes does Ciclesonide target when it's used to treat allergic rhinitis? | When used to treat allergic rhinitis, the drug Ciclesonide targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ciclesonide%" OR LOWER(tradeNames_list) LIKE "%ci... | [{'UUID': 'DrugTargetsIndication121923_text_217464', 'drugName': 'Ciclesonide', 'tradeNames_list': "['Alvesco', 'Alvesco 160', 'Alvesco 80', 'Omnaris', 'Zetonna']", 'syns_list': "['BI54903', 'Ciclesonide', 'RPR-251526', 'RPR251526']", 'target': 'ENSG00000113580', 'approvedSymbol': 'NR3C1', 'approvedName': 'nuclear rece... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1527 | Q6 | What genes does Ivabradine target when it's used to treat cardiovascular disease? | When used to treat cardiovascular disease, the drug Ivabradine targets the gene HCN4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%ivabradine%" OR LOWER(tradeNames_list) LIKE "%iva... | [{'UUID': 'DrugTargetsIndication121923_text_1148502', 'drugName': 'Ivabradine', 'tradeNames_list': "['Corlanor', 'Procoralan']", 'syns_list': "['Ivabradine', 'S-16257']", 'target': 'ENSG00000138622', 'approvedSymbol': 'HCN4', 'approvedName': 'hyperpolarization activated cyclic nucleotide gated potassium channel 4', 'me... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.362 | Q6 | What genes does Celecoxib target when it's used to treat hemorrhage? | When used to treat hemorrhage, the drug Celecoxib targets the gene PTGS2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%celecoxib%" OR LOWER(tradeNames_list) LIKE "%cele... | [{'UUID': 'DrugTargetsIndication121923_text_833158', 'drugName': 'Celecoxib', 'tradeNames_list': "['Celebra', 'Celebrex', 'Celecoxib', 'Elyxyb', 'Onsenal']", 'syns_list': "['Celecoxib', 'DFN-15', 'DFN15', 'NSC-719627', 'NSC-758624', 'SC-58635']", 'target': 'ENSG00000073756', 'approvedSymbol': 'PTGS2', 'approvedName': '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.976 | Q6 | What genes does Bivalirudin target when it's used to treat syndromic disease? | When used to treat syndromic disease, the drug Bivalirudin targets the gene F2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bivalirudin%" OR LOWER(tradeNames_list) LIKE "%bi... | [{'UUID': 'DrugTargetsIndication121923_text_1092331', 'drugName': 'Bivalirudin', 'tradeNames_list': "['Angiomax', 'Angiomax rtu', 'BivalirudinBivalirudin in 0.9% sodium chloride']", 'syns_list': "['BG-8967', 'BG8967', 'Bivalirudin']", 'target': 'ENSG00000180210', 'approvedSymbol': 'F2', 'approvedName': 'coagulation fac... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.790 | Q6 | What genes does Hydrocortisone target when it's used to treat inflammation? | When used to treat inflammation, the drug Hydrocortisone targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%hydrocortisone%" OR LOWER(tradeNames_list) LIKE "... | [{'UUID': 'DrugTargetsIndication121923_text_241717', 'drugName': 'Hydrocortisone', 'tradeNames_list': "['Acetasol hc', 'Acticort', 'Aeroseb-hc', 'Ala-cort', 'Ala-scalpAlkindi sprinkle', 'Alphaderm', 'Anflam', 'Anucort-Hc', 'Anugesic hcAnusol hc', 'Anusol plus hc', 'Anusol soothing relief', 'Anusol-HcBalneol-hc', 'Beta-... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.742 | Q6 | What genes does Empagliflozin target when it's used to treat diabetes mellitus? | When used to treat diabetes mellitus, the drug Empagliflozin targets the gene SLC5A2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%empagliflozin%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_1096709', 'drugName': 'Empagliflozin', 'tradeNames_list': "['Bi 10773', 'Jardiance']", 'syns_list': "['BI 10773', 'BI-10773', 'Bi10773', 'Empagliflozin']", 'target': 'ENSG00000140675', 'approvedSymbol': 'SLC5A2', 'approvedName': 'solute carrier family 5 member 2', 'mesh_headi... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1044 | Q6 | What genes does Desmopressin Acetate target when it's used to treat hemorrhage? | When used to treat hemorrhage, the drug Desmopressin Acetate targets the genes AVPR2, AVPR1A, and AVPR1B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%desmopressin acetate%" OR LOWER(tradeNames_list) ... | [{'UUID': 'DrugTargetsIndication121923_text_694760', 'drugName': 'Desmopressin Acetate', 'tradeNames_list': "['Concentraid', 'Ddavp', 'Ddavp (needs no refrigeration)', 'DesmomeltDesmopressin acetate', 'Desmopressin acetate (needs no refrigeration)Desmopressin acetate preservative free', 'Desmospray', 'DesmotabsMinirin'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.979 | Q6 | What genes does Montelukast target when it's used to treat acute myeloid leukemia? | Montelukast has not been approved by the FDA as a treatment for acute myeloid leukemia, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is CYSLTR1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%montelukast%" OR LOWER(tradeNames_list) LIKE "%mo... | [{'UUID': 'DrugTargetsIndication121923_text_1100405', 'drugName': 'Montelukast', 'tradeNames_list': "['Singulair']", 'syns_list': "['Brondilat', 'MK-476', 'Montelukast']", 'target': 'ENSG00000173198', 'approvedSymbol': 'CYSLTR1', 'approvedName': 'cysteinyl leukotriene receptor 1', 'mesh_heading': 'Leukemia, Myeloid, Ac... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1526 | Q6 | What genes does Axitinib target when it's used to treat renal carcinoma? | When used to treat renal carcinoma, the drug Axitinib targets the genes KDR, FLT1, and FLT4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%axitinib%" OR LOWER(tradeNames_list) LIKE "%axiti... | [{'UUID': 'DrugTargetsIndication121923_text_689242', 'drugName': 'Axitinib', 'tradeNames_list': "['Inlyta']", 'syns_list': "['AG-013736', 'AG-13736', 'Axitinib', 'NSC-757441']", 'target': 'ENSG00000128052', 'approvedSymbol': 'KDR', 'approvedName': 'kinase insert domain receptor', 'mesh_heading': 'Carcinoma, Renal Cell'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1488 | Q6 | What genes does Bosutinib target when it's used to treat chronic myelogenous leukemia? | When used to treat chronic myelogenous leukemia, the drug Bosutinib targets the genes ABL1, BCR, HCK, SRC, and LYN. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bosutinib%" OR LOWER(tradeNames_list) LIKE "%bosu... | [{'UUID': 'DrugTargetsIndication121923_text_712567', 'drugName': 'Bosutinib', 'tradeNames_list': "['Bosulif']", 'syns_list': "['Bosutinib', 'Bosutinib (as monohydrate)', 'Bosutinib hydrateBosutinib monohydrate', 'SK-606', 'SKI-606']", 'target': 'ENSG00000197122', 'approvedSymbol': 'SRC', 'approvedName': 'SRC proto-onco... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1525 | Q6 | What genes does Budesonide target when it's used to treat ulcerative colitis? | When used to treat ulcerative colitis, the drug Budesonide targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%budesonide%" OR LOWER(tradeNames_list) LIKE "%bud... | [{'UUID': 'DrugTargetsIndication121923_text_222614', 'drugName': 'Budesonide', 'tradeNames_list': "['Aircort', 'Budeflam aquanase', 'Budelin novolizer', 'BudenofalkBudesonide', 'Cortiment', 'Duoresp spiromax', 'Entocort', 'Entocort crEntocort ec', 'Ortikos', 'Preferid', 'Pulmaxan', 'PulmicortPulmicort flexhaler', 'Pulm... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1492 | Q6 | What genes does Nusinersen Sodium target when it's used to treat spinal muscular atrophy? | When used to treat spinal muscular atrophy, the drug Nusinersen Sodium targets the gene SMN2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%nusinersen sodium%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_1072719', 'drugName': 'Nusinersen Sodium', 'tradeNames_list': "['Spinraza']", 'syns_list': "['Nusinersen sodium']", 'target': 'ENSG00000205571', 'approvedSymbol': 'SMN2', 'approvedName': 'survival of motor neuron 2, centromeric', 'mesh_heading': 'Muscular Atrophy, Spinal', 'e... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1694 | Q6 | What genes does Brivaracetam target when it's used to treat Unverricht-Lundborg disease? | Brivaracetam has not been approved by the FDA as a treatment for Unverricht-Lundborg disease, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is SV2A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%brivaracetam%" OR LOWER(tradeNames_list) LIKE "%b... | [{'UUID': 'DrugTargetsIndication121923_text_1097448', 'drugName': 'Brivaracetam', 'tradeNames_list': "['Briviact']", 'syns_list': "['Brivaracetam', 'UCB 34714', 'UCB-34714']", 'target': 'ENSG00000159164', 'approvedSymbol': 'SV2A', 'approvedName': 'synaptic vesicle glycoprotein 2A', 'mesh_heading': 'Unverricht-Lundborg ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1716 | Q6 | What genes does Epinephrine target when it's used to treat sudden cardiac arrest? | When used to treat sudden cardiac arrest, the drug Epinephrine targets the genes ADRA1A, ADRB2, ADRB1, ADRB3, ADRA1D, ADRA1B, ADRA2A, ADRA2C, and ADRA2B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%epinephrine%" OR LOWER(tradeNames_list) LIKE "%ep... | [{'UUID': 'DrugTargetsIndication121923_text_365066', 'drugName': 'Epinephrine', 'tradeNames_list': "['Adren co', 'Adrenaclick', 'Adrenalin', 'Ana-Kit', 'Ana-guard', 'AnapenAnaphylactic shock drug kit', 'Asma-vydrin', 'Asthmahaler', 'Auvi-qBronkaid mist', 'Brovon', 'Emerade', 'Epi e z pen jr', 'EpinephrineEpinephrine (c... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1246 | Q6 | What genes does Prednisone target when it's used to treat arthritis? | When used to treat arthritis, the drug Prednisone targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%prednisone%" OR LOWER(tradeNames_list) LIKE "%pre... | [{'UUID': 'DrugTargetsIndication121923_text_217679', 'drugName': 'Prednisone', 'tradeNames_list': "['Cortan', 'Cortancyl', 'Decortisyl', 'Delta-dome', 'Deltasone', 'FernisoneLiquid pred', 'Lodotra', 'Meticorten', 'Orasone', 'Paracort', 'Prednicen-mPrednisone', 'Prednisone intensol', 'Rayos', 'Servisone', 'Sterapred']",... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.892 | Q6 | What genes does Nilotinib Hydrochloride Monohydrate target when it's used to treat chronic myelogenous leukemia? | When used to treat chronic myelogenous leukemia, the drug Nilotinib Hydrochloride Monohydrate targets the genes ABL1 and BCR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%nilotinib hydrochloride monohydrate%" OR LOWER(tr... | [{'UUID': 'DrugTargetsIndication121923_text_745306', 'drugName': 'Nilotinib Hydrochloride Monohydrate', 'tradeNames_list': "['Tasigna']", 'syns_list': "['Nilotinib (as hydrochloride)', 'Nilotinib Hydrochloride MonohydrateNilotinib hydrochloride', 'Nilotinib hydrochloride anhydrousNilotinib hydrochloride hydrate', 'Nilo... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.82 | Q6 | What genes does Degarelix Acetate target when it's used to treat prostate adenocarcinoma? | When used to treat prostate adenocarcinoma, the drug Degarelix Acetate targets the gene GNRHR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%degarelix acetate%" OR LOWER(tradeNames_list) LIK... | [{'UUID': 'DrugTargetsIndication121923_text_1097143', 'drugName': 'Degarelix Acetate', 'tradeNames_list': "['Firmagon']", 'syns_list': "['Degarelix (as acetate)', 'Degarelix acetate', 'Degarelix acetate hydrateFE-200486', 'FE200486', 'FE200486 (FREE BASE)']", 'target': 'ENSG00000109163', 'approvedSymbol': 'GNRHR', 'app... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1182 | Q6 | What genes does Selpercatinib target when it's used to treat thyroid cancer? | When used to treat thyroid cancer, the drug Selpercatinib targets the genes RET, CCDC6, and KIF5B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%selpercatinib%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_944411', 'drugName': 'Selpercatinib', 'tradeNames_list': "['Retevmo']", 'syns_list': "['LOXO-292', 'LY-3527723', 'LY3527723', 'Loxo-292', 'Ret inhibitor loxo-292Selpercatinib']", 'target': 'ENSG00000165731', 'approvedSymbol': 'RET', 'approvedName': 'ret proto-oncogene', 'mesh... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.821 | Q6 | What genes does Topotecan Hydrochloride target when it's used to treat anaplastic oligodendroglioma? | Topotecan Hydrochloride has not been approved by the FDA as a treatment for anaplastic oligodendroglioma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is TOP1MT. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%topotecan hydrochloride%" OR LOWER(tradeNames_lis... | [{'UUID': 'DrugTargetsIndication121923_text_1193518', 'drugName': 'Topotecan Hydrochloride', 'tradeNames_list': "['Hycamptin', 'Hycamtin', 'Topotecan', 'Topotecan hydrochloride']", 'syns_list': "['Evotopin', 'NSC-759263', 'Nogitecan hydrochloride', 'SK&F S-104864-ASK&F-S-104864A', 'SK-S-104864-A', 'Topotecan (as hydroc... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1283 | Q6 | What genes does Fexofenadine Hydrochloride target when it's used to treat seasonal allergic rhinitis? | When used to treat seasonal allergic rhinitis, the drug Fexofenadine Hydrochloride targets the gene HRH1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%fexofenadine hydrochloride%" OR LOWER(tradeNames_... | [{'UUID': 'DrugTargetsIndication121923_text_455783', 'drugName': 'Fexofenadine Hydrochloride', 'tradeNames_list': '[\'Allegra\', \'Allegra allergy\', \'Allegra hives\', "Children\'s allegra allergyChildren\'s allegra hivesChildren\'s fexofenadine hydrochloride allergyChildren\'s fexofenadine hydrochloride hivesFexofena... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.678 | Q6 | What genes does Gilteritinib Fumarate target when it's used to treat myeloid leukemia? | When used to treat myeloid leukemia, the drug Gilteritinib Fumarate targets the genes FLT3 and AXL. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%gilteritinib fumarate%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_933934', 'drugName': 'Gilteritinib Fumarate', 'tradeNames_list': "['Xospata']", 'syns_list': "['ASP-2215 HEMIFUMARATE', 'ASP2215 hemifumarate', 'Gilteritinib fumarateGilteritinib hemifumarate']", 'target': 'ENSG00000122025', 'approvedSymbol': 'FLT3', 'approvedName': 'fms rela... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1533 | Q6 | What genes does Cabozantinib S-Malate target when it's used to treat thyroid carcinoma? | When used to treat thyroid carcinoma, the drug Cabozantinib S-Malate targets the genes KDR and MET. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%cabozantinib s-malate%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_670547', 'drugName': 'Cabozantinib S-Malate', 'tradeNames_list': "['Cabometyx', 'Cometriq']", 'syns_list': "['BMS-907351', 'Cabozantinib malate', 'Cabozantinib s-malate', 'XL-184XL184']", 'target': 'ENSG00000128052', 'approvedSymbol': 'KDR', 'approvedName': 'kinase insert dom... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.59 | Q6 | What genes does Bosentan target when it's used to treat pulmonary arterial hypertension? | When used to treat pulmonary arterial hypertension, the drug Bosentan targets the genes EDNRA and EDNRB. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%bosentan%" OR LOWER(tradeNames_list) LIKE "%bosen... | [{'UUID': 'DrugTargetsIndication121923_text_1084238', 'drugName': 'Bosentan', 'tradeNames_list': "['Tracleer']", 'syns_list': "['Anhydrous bosentan', 'Bosentan', 'Bosentan anhydrous', 'Bosentan hydrateBosentan monohydrate', 'RO 47-0203/029', 'RO-47-0203-029', 'RO-470203029']", 'target': 'ENSG00000151617', 'approvedSymb... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.136 | Q6 | What genes does Methotrexate target when it's used to treat immune system disease? | When used to treat immune system disease, the drug Methotrexate targets the gene DHFR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%methotrexate%" OR LOWER(tradeNames_list) LIKE "%m... | [{'UUID': 'DrugTargetsIndication121923_text_1057586', 'drugName': 'Methotrexate', 'tradeNames_list': "['Amethopterin', 'Ebetrex', 'Emtexate high-pot', 'Emtexate pf', 'FolexMaxtrex', 'Methotrexate', 'Metoject', 'Mexate', 'Otrexup', 'Otrexup pfsRasuvo', 'Reditrex', 'Rheumatrex', 'Trexall', 'Zlatal']", 'syns_list': "['(r)... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1150 | Q6 | What genes does Doxepin Hydrochloride target when it's used to treat insomnia? | When used to treat insomnia, the drug Doxepin Hydrochloride targets the gene SLC6A2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%doxepin hydrochloride%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_440817', 'drugName': 'Doxepin Hydrochloride', 'tradeNames_list': "['Adapin', 'Doxepin hydrochloride', 'Quitaxon', 'Silenor', 'Sinequan', 'XepinZonalon']", 'syns_list': "['Doxepin hcl', 'Doxepin hydrochloride', 'NSC-108160', 'P-3693A']", 'target': 'ENSG00000103546', 'approvedS... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.942 | Q6 | What genes does Hydrocortisone target when it's used to treat eye inflammation? | When used to treat eye inflammation, the drug Hydrocortisone targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%hydrocortisone%" OR LOWER(tradeNames_list) LIKE "... | [{'UUID': 'DrugTargetsIndication121923_text_241225', 'drugName': 'Hydrocortisone', 'tradeNames_list': "['Acetasol hc', 'Acticort', 'Aeroseb-hc', 'Ala-cort', 'Ala-scalpAlkindi sprinkle', 'Alphaderm', 'Anflam', 'Anucort-Hc', 'Anugesic hcAnusol hc', 'Anusol plus hc', 'Anusol soothing relief', 'Anusol-HcBalneol-hc', 'Beta-... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1685 | Q6 | What genes does Hydrocortisone target when it's used to treat hemorrhoid? | When used to treat hemorrhoid, the drug Hydrocortisone targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%hydrocortisone%" OR LOWER(tradeNames_list) LIKE "... | [{'UUID': 'DrugTargetsIndication121923_text_241226', 'drugName': 'Hydrocortisone', 'tradeNames_list': "['Acetasol hc', 'Acticort', 'Aeroseb-hc', 'Ala-cort', 'Ala-scalpAlkindi sprinkle', 'Alphaderm', 'Anflam', 'Anucort-Hc', 'Anugesic hcAnusol hc', 'Anusol plus hc', 'Anusol soothing relief', 'Anusol-HcBalneol-hc', 'Beta-... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.830 | Q6 | What genes does Acalabrutinib Maleate target when it's used to treat Mantle cell lymphoma? | When used to treat Mantle cell lymphoma, the drug Acalabrutinib Maleate targets the gene BTK. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%acalabrutinib maleate%" OR LOWER(tradeNames_list)... | [{'UUID': 'DrugTargetsIndication121923_text_1024995', 'drugName': 'Acalabrutinib Maleate', 'tradeNames_list': "['Calquence']", 'syns_list': "['Acalabrutinib maleate', 'Acalabrutinib maleate anhydrousCalquence maleate']", 'target': 'ENSG00000010671', 'approvedSymbol': 'BTK', 'approvedName': 'Bruton tyrosine kinase', 'me... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1224 | Q6 | What genes does Afatinib target when it's used to treat cancer? | When used to treat cancer, the drug Afatinib targets the genes EGFR, ERBB2, and ERBB4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%afatinib%" OR LOWER(tradeNames_list) LIKE "%afati... | [{'UUID': 'DrugTargetsIndication121923_text_207795', 'drugName': 'Afatinib', 'tradeNames_list': "['Gilotrif', 'Giotrif']", 'syns_list': "['Afatinib', 'BIBW-2992', 'BIBW2992', 'Bibw 2992', 'NSC-750691', 'TomtovokTovok']", 'target': 'ENSG00000146648', 'approvedSymbol': 'EGFR', 'approvedName': 'epidermal growth factor rec... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.510 | Q6 | What genes does Mometasone Furoate target when it's used to treat Airway obstruction? | When used to treat Airway obstruction, the drug Mometasone Furoate targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%mometasone furoate%" OR LOWER(tradeNames_list) LI... | [{'UUID': 'DrugTargetsIndication121923_text_242037', 'drugName': 'Mometasone Furoate', 'tradeNames_list': "['Asmanex', 'Asmanex hfa', 'Asmanex twisthaler', 'EloconMometasone furoate', 'Nasonex', 'Nasonex 24hr allergy', 'Sinuva']", 'syns_list': "['LAS-41002', 'LAS41002', 'LYR-210', 'LYR210', 'Lyr-210', 'MometasoneMometa... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1776 | Q6 | What genes does Amiodarone Hydrochloride target when it's used to treat ventricular tachycardia? | When used to treat ventricular tachycardia, the drug Amiodarone Hydrochloride targets the gene KCNH2. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%amiodarone hydrochloride%" OR LOWER(tradeNames_li... | [{'UUID': 'DrugTargetsIndication121923_text_969595', 'drugName': 'Amiodarone Hydrochloride', 'tradeNames_list': "['Amidox', 'Amiodarone hydrochloride', 'Amyben', 'Cordarone', 'Cordarone xCordarone x 100', 'Cordarone x 200', 'Darmil', 'Nexterone', 'Pacerone']", 'syns_list': "['Amiodar', 'Amiodarone', 'Amiodarone hcl', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.351 | Q6 | What genes does Amlodipine Besylate target when it's used to treat hypertension? | When used to treat hypertension, the drug Amlodipine Besylate targets the genes CACNA1C, CACNA1S, CACNA1D, and CACNA1F. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%amlodipine besylate%" OR LOWER(tradeNames_list) L... | [{'UUID': 'DrugTargetsIndication121923_text_1043678', 'drugName': 'Amlodipine Besylate', 'tradeNames_list': "['Amlodipine besylate', 'Norliqva', 'Norvasc']", 'syns_list': "['Amlodipine (as besilate)', 'Amlodipine benzenesulfonateAmlodipine besilate', 'Amlodipine besylate', 'Amlor', 'AntacalLodipressin', 'Monopina', 'NS... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.392 | Q6 | What genes does Pomalidomide target when it's used to treat non-Hodgkins lymphoma? | Pomalidomide has not been approved by the FDA as a treatment for non-Hodgkins lymphoma, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are CRBN, DDB1, CUL4A, and RBX1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%pomalidomide%" OR LOWER(tradeNames_list) LIKE "%p... | [{'UUID': 'DrugTargetsIndication121923_text_1141304', 'drugName': 'Pomalidomide', 'tradeNames_list': "['Imnovid', 'Pomalyst']", 'syns_list': "['Actimid', 'CC-4047', 'IMID 3', 'IMID-3', 'Pomalidomide']", 'target': 'ENSG00000113851', 'approvedSymbol': 'CRBN', 'approvedName': 'cereblon', 'mesh_heading': 'Lymphoma, Non-Hod... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1033 | Q6 | What genes does Betamethasone Dipropionate target when it's used to treat Airway obstruction? | When used to treat Airway obstruction, the drug Betamethasone Dipropionate targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%betamethasone dipropionate%" OR LOWER(tradeNames_... | [{'UUID': 'DrugTargetsIndication121923_text_220891', 'drugName': 'Betamethasone Dipropionate', 'tradeNames_list': "['Alphatrex', 'Betamethasone dipropionate', 'Diprolene', 'Diprolene afDiprosone', 'Sernivo']", 'syns_list': "['Betamethasone (as dipropionate)', 'Betamethasone 17,21-dipropionateBetamethasone dipropionate'... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.901 | Q6 | What genes does Omeprazole target when it's used to treat gastric ulcer? | When used to treat gastric ulcer, the drug Omeprazole targets the genes ATP4A and ATP4B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%omeprazole%" OR LOWER(tradeNames_list) LIKE "%ome... | [{'UUID': 'DrugTargetsIndication121923_text_1098039', 'drugName': 'Omeprazole', 'tradeNames_list': "['Antra', 'Losec', 'Losec mups', 'Mezzopram', 'Mopral', 'Omeprazole', 'OmeranPrilosec', 'Zanprol']", 'syns_list': "['H 168/68', 'H-168/68', 'NSC-751450', 'NSC-759192', 'Omeprazole']", 'target': 'ENSG00000105675', 'approv... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.835 | Q6 | What genes does Voxelotor target when it's used to treat sickle cell anemia? | When used to treat sickle cell anemia, the drug Voxelotor targets the genes HBA1, HBA2, and HBB. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%voxelotor%" OR LOWER(tradeNames_list) LIKE "%voxe... | [{'UUID': 'DrugTargetsIndication121923_text_1095609', 'drugName': 'Voxelotor', 'tradeNames_list': "['Oxbryta']", 'syns_list': "['GBT-440', 'GBT440', 'GTX-011', 'Gbt440', 'Voxelotor']", 'target': 'ENSG00000206172', 'approvedSymbol': 'HBA1', 'approvedName': 'hemoglobin subunit alpha 1', 'mesh_heading': 'Anemia, Sickle Ce... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1894 | Q6 | What genes does Paclitaxel target when it's used to treat chronic lymphocytic leukemia? | Paclitaxel has not been approved by the FDA as a treatment for chronic lymphocytic leukemia, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are TUBB4B, TUBB1, TUBA3C, TUBA4A, TUBB3, TUBA1A, TUBB4A, TUBB8, TUBB, TUBA1B, TUBA1C, TUBA3E, TUBB2A, TUBB2B, and TUBB6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%paclitaxel%" OR LOWER(tradeNames_list) LIKE "%pac... | [{'UUID': 'DrugTargetsIndication121923_text_781', 'drugName': 'Paclitaxel', 'tradeNames_list': "['Abraxane', 'Pacitaxel', 'Paclitaxel', 'Paxene', 'Taxol', 'Taxol 100']", 'syns_list': "['(-)-paclitaxel', 'ABI-007', 'ABI-007 COMPONENT PACLITAXEL', 'BMS 181339-01BMS-181339-01', 'Capxol', 'Cyclopax', 'DHP 107', 'DHP-107', ... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.481 | Q6 | What genes does Riociguat target when it's used to treat cystic fibrosis? | Riociguat has not been approved by the FDA as a treatment for cystic fibrosis, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are GUCY1B1, GUCY1B2, GUCY1A2, and GUCY1A1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%riociguat%" OR LOWER(tradeNames_list) LIKE "%rioc... | [{'UUID': 'DrugTargetsIndication121923_text_972969', 'drugName': 'Riociguat', 'tradeNames_list': "['Adempas', 'Bay 63-2521']", 'syns_list': "['BAY 63-2521', 'BAY-63-2521', 'Riociguat']", 'target': 'ENSG00000061918', 'approvedSymbol': 'GUCY1B1', 'approvedName': 'guanylate cyclase 1 soluble subunit beta 1', 'mesh_heading... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1472 | Q6 | What genes does Pegcetacoplan target when it's used to treat thrombotic microangiopathy? | Pegcetacoplan has not been approved by the FDA as a treatment for thrombotic microangiopathy, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is C3. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%pegcetacoplan%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_1103144', 'drugName': 'Pegcetacoplan', 'tradeNames_list': "['Empaveli']", 'syns_list': "['APL-2', 'Pegcetacoplan']", 'target': 'ENSG00000125730', 'approvedSymbol': 'C3', 'approvedName': 'complement C3', 'mesh_heading': 'Thrombotic Microangiopathies', 'efo_term': 'thrombotic m... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1887 | Q6 | What genes does Naltrexone target when it's used to treat alcohol abuse? | When used to treat alcohol abuse, the drug Naltrexone targets the genes OPRM1, OPRK1, and OPRD1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%naltrexone%" OR LOWER(tradeNames_list) LIKE "%nal... | [{'UUID': 'DrugTargetsIndication121923_text_785289', 'drugName': 'Naltrexone', 'tradeNames_list': "['Celupan', 'Trexal', 'Trexan', 'Vivitrol']", 'syns_list': "['EN-1639A', 'EN-1639A FREE BASE', 'EN-1639A [AS HYDROCHLORIDE]NSC-758439', 'Naltrexone', 'Revia']", 'target': 'ENSG00000116329', 'approvedSymbol': 'OPRD1', 'app... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1398 | Q6 | What genes does Pregabalin target when it's used to treat neuropathic pain? | When used to treat neuropathic pain, the drug Pregabalin targets the genes CACNA1B, CACNA1C, CACNA1S, CACNA1D, CACNA1F, CACNA2D2, CACNA2D1, CACNA1H, CACNA1G, CACNA1I, CACNA1A, CACNA2D3, CACNA2D4, CACNA1E, CACNB4, CACNB2, CACNB1, CACNB3, CACNG7, CACNG5, CACNG2, CACNG4, CACNG8, CACNG3, CACNG6, and CACNG1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%pregabalin%" OR LOWER(tradeNames_list) LIKE "%pre... | [{'UUID': 'DrugTargetsIndication121923_text_859588', 'drugName': 'Pregabalin', 'tradeNames_list': "['Alzain', 'Axalid', 'Lecaent', 'Lyrica', 'Lyrica cr', 'Pregabalin', 'Rewisca']", 'syns_list': "['CI-1008', 'NSC-759256', 'PD-144723', 'Pregabalin', 'Pregabalin mylanPregabalin sandoz', 'Pregabalin sandoz gmbh', 'Pregabal... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.659 | Q6 | What genes does Rosuvastatin Calcium target when it's used to treat hyperlipidemia? | When used to treat hyperlipidemia, the drug Rosuvastatin Calcium targets the gene HMGCR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%rosuvastatin calcium%" OR LOWER(tradeNames_list) ... | [{'UUID': 'DrugTargetsIndication121923_text_1104169', 'drugName': 'Rosuvastatin Calcium', 'tradeNames_list': "['Crestor', 'Ezallor', 'Ezallor sprinkle', 'Rosuvastatin calcium']", 'syns_list': "['Fortius', 'NSC-747274', 'NSC-758930', 'Rostar', 'Rosuvastatin (as calcium)Rosuvastatin calcium', 'Rosuvastatin calcium saltRo... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.175 | Q6 | What genes does Cabozantinib target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Cabozantinib targets the genes KDR and MET. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%cabozantinib%" OR LOWER(tradeNames_list) LIKE "%c... | [{'UUID': 'DrugTargetsIndication121923_text_669860', 'drugName': 'Cabozantinib S-Malate', 'tradeNames_list': "['Cabometyx', 'Cometriq']", 'syns_list': "['BMS-907351', 'Cabozantinib malate', 'Cabozantinib s-malate', 'XL-184XL184']", 'target': 'ENSG00000128052', 'approvedSymbol': 'KDR', 'approvedName': 'kinase insert dom... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1159 | Q6 | What genes does Vilazodone Hydrochloride target when it's used to treat unipolar depression? | When used to treat unipolar depression, the drug Vilazodone Hydrochloride targets the genes SLC6A4 and HTR1A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%vilazodone hydrochloride%" OR LOWER(tradeNames_li... | [{'UUID': 'DrugTargetsIndication121923_text_207060', 'drugName': 'Vilazodone Hydrochloride', 'tradeNames_list': "['Viibryd']", 'syns_list': "['EMD 68 843', 'EMD-68843', 'SB-659746-A', 'SB659746-A', 'Vilazodone hclVilazodone hydrochloride']", 'target': 'ENSG00000108576', 'approvedSymbol': 'SLC6A4', 'approvedName': 'solu... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.39 | Q6 | What genes does Lurasidone Hydrochloride target when it's used to treat schizophrenia? | When used to treat schizophrenia, the drug Lurasidone Hydrochloride targets the genes DRD2 and HTR2A. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%lurasidone hydrochloride%" OR LOWER(tradeNames_li... | [{'UUID': 'DrugTargetsIndication121923_text_197915', 'drugName': 'Lurasidone Hydrochloride', 'tradeNames_list': "['Latuda']", 'syns_list': "['Lurasidone hcl', 'Lurasidone hydrochloride', 'SM-13496']", 'target': 'ENSG00000149295', 'approvedSymbol': 'DRD2', 'approvedName': 'dopamine receptor D2', 'mesh_heading': 'Schizop... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.720 | Q6 | What genes does Docetaxel target when it's used to treat breast neoplasm? | When used to treat breast neoplasm, the drug Docetaxel targets the genes TUBB4B, TUBB1, TUBA3C, TUBA4A, TUBB3, TUBA1A, TUBB4A, TUBB8, TUBB, TUBA1B, TUBA1C, TUBA3E, TUBB2A, TUBB2B, and TUBB6. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%docetaxel%" OR LOWER(tradeNames_list) LIKE "%doce... | [{'UUID': 'DrugTargetsIndication121923_text_97536', 'drugName': 'Docetaxel', 'tradeNames_list': "['Docefrez', 'Docetaxel', 'Taxceus', 'Taxotere']", 'syns_list': "['Bind 014', 'CKD-810', 'Docetaxel', 'Docetaxel (as trihydrate)Docetaxel anhydrous', 'Docetaxel hydrate', 'Docetaxel trihydrateNSC-628503', 'RP 56976', 'RP-56... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.93 | Q6 | What genes does Pemetrexed target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Pemetrexed targets the genes TYMS, GART, and DHFR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%pemetrexed%" OR LOWER(tradeNames_list) LIKE "%pem... | [{'UUID': 'DrugTargetsIndication121923_text_918479', 'drugName': 'Pemetrexed', 'tradeNames_list': "['Alimta', 'Pemfexy']", 'syns_list': "['LY-2315', 'LY-231514', 'LY231514', 'NSC-698037', 'Pemetrexed']", 'target': 'ENSG00000176890', 'approvedSymbol': 'TYMS', 'approvedName': 'thymidylate synthetase', 'mesh_heading': 'Ne... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1937 | Q6 | What genes does Epinephrine target when it's used to treat type III hypersensitivity reaction disease? | When used to treat type III hypersensitivity reaction disease, the drug Epinephrine targets the genes ADRA1A, ADRB2, ADRB1, ADRB3, ADRA1D, ADRA1B, ADRA2A, ADRA2C, and ADRA2B. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%epinephrine%" OR LOWER(tradeNames_list) LIKE "%ep... | [{'UUID': 'DrugTargetsIndication121923_text_361099', 'drugName': 'Epinephrine', 'tradeNames_list': "['Adren co', 'Adrenaclick', 'Adrenalin', 'Ana-Kit', 'Ana-guard', 'AnapenAnaphylactic shock drug kit', 'Asma-vydrin', 'Asthmahaler', 'Auvi-qBronkaid mist', 'Brovon', 'Emerade', 'Epi e z pen jr', 'EpinephrineEpinephrine (c... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1215 | Q6 | What genes does Aspirin target when it's used to treat non-allergic rhinitis? | When used to treat non-allergic rhinitis, the drug Aspirin targets the genes PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%aspirin%" OR LOWER(tradeNames_list) LIKE "%aspiri... | [{'UUID': 'DrugTargetsIndication121923_text_834438', 'drugName': 'Aspirin', 'tradeNames_list': "['8-hour bayer', 'Acetosalic Acid', 'Acetylsalic acidAcetylsalicylic Acid', 'Alka rapid', 'Anadin all night', 'Angettes 75Aspirin', 'Aspro clr', 'Bayer extra strength aspirin for migraine painDanamep', 'Disprin cv', 'Disprin... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.882 | Q6 | What genes does Relugolix target when it's used to treat neoplasm? | When used to treat neoplasm, the drug Relugolix targets the gene GNRHR. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%relugolix%" OR LOWER(tradeNames_list) LIKE "%relu... | [{'UUID': 'DrugTargetsIndication121923_text_1096971', 'drugName': 'Relugolix', 'tradeNames_list': "['Orgovyx']", 'syns_list': "['Relugolix', 'TAK-385', 'Tak-385']", 'target': 'ENSG00000109163', 'approvedSymbol': 'GNRHR', 'approvedName': 'gonadotropin releasing hormone receptor', 'mesh_heading': 'Prostatic Neoplasms', '... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1353 | Q6 | What genes does Dexamethasone target when it's used to treat rheumatoid arthritis? | When used to treat rheumatoid arthritis, the drug Dexamethasone targets the gene NR3C1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%dexamethasone%" OR LOWER(tradeNames_list) LIKE "%... | [{'UUID': 'DrugTargetsIndication121923_text_227753', 'drugName': 'Dexamethasone', 'tradeNames_list': "['Aeroseb-dex', 'Dalalone', 'Decaderm', 'Decadron', 'Decadron-75', 'DecasprayDexacortisyl', 'Dexafree', 'Dexamethasone', 'Dexamethasone intensolDexone', 'Dexone 0.5', 'Dexone 0.75', 'Dexone 1.5', 'Dexone 4', 'DexsolDex... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1891 | Q6 | What genes does Imiquimod target when it's used to treat leukemia? | Imiquimod has not been approved by the FDA as a treatment for leukemia, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene target is TLR7. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%imiquimod%" OR LOWER(tradeNames_list) LIKE "%imiq... | [{'UUID': 'DrugTargetsIndication121923_text_920120', 'drugName': 'Imiquimod', 'tradeNames_list': "['Aldara', 'Imiquimod', 'Zyclara']", 'syns_list': "['Aldara', 'Imiquimod', 'NSC-369100', 'NSC-759651', 'R-837', 'S-26308', 'S26308Tmx-101']", 'target': 'ENSG00000196664', 'approvedSymbol': 'TLR7', 'approvedName': 'toll lik... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1102 | Q6 | What genes does Thalidomide target when it's used to treat pain? | Thalidomide has not been approved by the FDA as a treatment for pain, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are CRBN, DDB1, CUL4A, and RBX1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%thalidomide%" OR LOWER(tradeNames_list) LIKE "%th... | [{'UUID': 'DrugTargetsIndication121923_text_1105070', 'drugName': 'Thalidomide', 'tradeNames_list': "['Talidex', 'Thalomid']", 'syns_list': "['.alpha.-phthalimidoglutarimide', 'Celgene', 'Contergan', 'Distaval', 'K-17Myrin', 'N-phthalylglutamic acid imide', 'NSC-527179', 'NSC-66847Neurosedyn', 'Pantosediv', 'Pharmion',... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1165 | Q6 | What genes does Aspirin target when it's used to treat Fatigue? | Aspirin has not been approved by the FDA as a treatment for Fatigue, but it is currently undergoing evaluation in clinical trials for this purpose. The proposed gene targets are PTGS2 and PTGS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%aspirin%" OR LOWER(tradeNames_list) LIKE "%aspiri... | [{'UUID': 'DrugTargetsIndication121923_text_834444', 'drugName': 'Aspirin', 'tradeNames_list': "['8-hour bayer', 'Acetosalic Acid', 'Acetylsalic acidAcetylsalicylic Acid', 'Alka rapid', 'Anadin all night', 'Angettes 75Aspirin', 'Aspro clr', 'Bayer extra strength aspirin for migraine painDanamep', 'Disprin cv', 'Disprin... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1365 | Q6 | What genes does Metoclopramide Hydrochloride target when it's used to treat cancer? | When used to treat cancer, the drug Metoclopramide Hydrochloride targets the genes DRD2, HTR3A, and HTR4. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%metoclopramide hydrochloride%" OR LOWER(tradeName... | [{'UUID': 'DrugTargetsIndication121923_text_199702', 'drugName': 'Metoclopramide Hydrochloride', 'tradeNames_list': '[\'"clopra-""yellow"""\', \'Clopra\', \'Clopra-"Yellow"\', \'Gastrese l.a.Gastrobid continus\', \'Gastroflux\', \'Gastromax\', \'Gimoti\', \'MaxolonMaxolon sr\', \'Metoclomex\', \'Metoclopramide hydrochl... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
Q6.1959 | Q6 | What genes does Belzutifan target when it's used to treat von Hippel-Lindau disease? | When used to treat von Hippel-Lindau disease, the drug Belzutifan targets the gene EPAS1. | SELECT DISTINCT UUID, drugName, tradeNames_list, syns_list, target, approvedSymbol, approvedName, mesh_heading, efo_term, yearOfFirstApproval, max_phase_for_ind
FROM `{project_id}.{dataset_name}.DrugTargets_IndicationsAndTherapeuticUses`
WHERE (LOWER(drugName) LIKE "%belzutifan%" OR LOWER(tradeNames_list) LIKE "%bel... | [{'UUID': 'DrugTargetsIndication121923_text_1192114', 'drugName': 'Belzutifan', 'tradeNames_list': "['Welireg']", 'syns_list': "['Belzutifan', 'MK-6482', 'MK6482', 'Mk-6482', 'PT-2977', 'PT2977', 'Pt 2977Pt2977']", 'target': 'ENSG00000116016', 'approvedSymbol': 'EPAS1', 'approvedName': 'endothelial PAS domain protein 1... | general | Distinct, Order By, Similarity Search | Genetic Target, Approval Status |
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