0 stringlengths 12 494 | embeddings listlengths 384 384 |
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tumor\ton\tthe\tadrenal\tor\tpituitary\tgland.\tWeight\tgain,\tinsulin\tresistance,\thigh\tblood\tsugar,\texcessive\nthirst,\teasy\tbruising,\tdepression,\tmuscle\tloss,\n\tand\tweakness\tare\tcommon\tsymptoms.\tBecause\tcortisol | [
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causes\tbone\tloss\tover\ttime,\ta\tdiet\trich\tin\tcalcium\tand\tvitamin\tD\tmay\thelp\tprevent\tosteoporosis.\nReducing\tsodium,\toptimal\thydration,\tand\tcaloric\tawareness\tcan\talso\tassist\twith\tweight\tmanagement\nand\tthe\tprevention\tof\tfluid\tretention.\nAddison’s\tdisease\nPrimary\tadrenal\tinsufficiency,... | [
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Addison’s\tdisease\n,\tis\trare.\tIn\tthis\tcondition,\ninsufficient\tsteroid\thormones\tare\tproduced\tin\tspite\tof\tadequate\tlevels\tof\tthe\thormone\nadrenocorticotropic\thormone\t(ACTH).\tPeople\twith\tAddison’s\tdisease\tlose\tthe\tability\tto\tappropriately\nregulate\tblood\tsugar\tand\twill\thave\tlow\tlevels\... | [
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norepinephrine.\tThis\tleads\tto\tloss\tof\tappetite,\tfatigue,\tlow\tblood\tpressure,\tnausea\tand\tvomiting,\tand,\nfor\tsome,\tdarkening\tof\n\tskin\ton\tthe\tface\tand\tneck.\tPatients\twith\tAddison’s\tdisease\thave\tan\tincreased\nneed\tfor\tsalt\tand\twater\tand\talso\tneed\tto\teat\tregular\tbalanced\tmeals\t(w... | [
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carbohydrate\tand\tprotein)\tto\tregulate\tblood\tsugar.\nAdrenal\tinsufficiency/adrenal\tfatigue\nAdrenal\tfatigue\n\thas\tbeen\tidentified\tas\ta\tcollection\tof\tsigns\tand\tsymptoms\tcaused\tby\tthe\tdecreased\nability\tof\tthe\tadrenal\tglands\tto\trespond\n\tadequately\tto\tstress.\tA\tvariety\tof\tterms\tare\tfo... | [
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adequately\tto\tstress.\tA\tvariety\tof\tterms\tare\tfound\tin\tthe\nscientific\tliterature\tthat\taddress\tadrenal\tfatigue,\tincluding\tsubclinical\tadrenal\tinsufficiency,\tadrenal\nstress,\tadrenal\texhaustion,\tadrenal\tburnout,\tand\tadrenal\timbalance\t(\nAllen\tJr,\t2013\n).\tThe\tadrenals | [
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Allen\tJr,\t2013\n).\tThe\tadrenals\nare\tthe\ttwo\ttriangular-shaped\tglands\tlocated\tat\tthe\ttop\tof\teach\tkidney\tand\tare\tresponsible\tprimarily\nfor\tgoverning\tthe\tbody’s\tadaptations\n\tto\tstress\tof\tany\tkind.\tUnder\tthe\tinfluence\tof\tstress,\tthe\nadrenals\twill\trespond\twith\tincreased\thormone\tpr... | [
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blood\tpressure.\tOver\ttime,\tthe\tadrenal\tcan\tbecome\tdecompensated,\twhere\tthe\thormone\toutput\tmay\nbe\tdiminished.\tThis\tis\toften\treferred\tto\tas\tadrenal\tfatigue.\tThis\tcan\toccur\twhether\tthe\tsource\tof\nstress—physical,\temotional,\tor\tpsychological—is\tchronic\n\tand\tcontinues\tto\tpersist\tcausi... | [
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and\tcontinues\tto\tpersist\tcausing\ta\ncumulative\teffect,\tor\tis\ta\tvery\tintense\tsingle\tevent\tstressor.\tIn\tother\twords,\tthe\tadrenal\tglands\tare\nunable\tto\tkeep\tpace\twith\tthe\tdemands\tof\tperpetual\tfight-or-flight\tarousal,\tresulting\tin\tsubclinical\nadrenal\tdysfunction.\tThe\tmost\tcommon\tsymp... | [
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excessive\tfatigue\tand\texhaustion,\thair\tloss,\thypoglycemia,\n\thormone\timbalance,\tpoor\tdigestion,\tlow\nimmune\tfunction,\tslow\trecovery\tfrom\tillness,\tinability\tto\tconcentrate,\tand\tinability\tto\tcope\twith\nstressors.\nChronic\tadrenal\tstress\tcauses\tthe\tfollowing\t(\nSun\tet\tal,\t2016\n;\t\nTsigos... | [
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Sun\tet\tal,\t2016\n;\t\nTsigos\tand\tChrousos,\t2002\n):\n•\t\nAffects\tcommunication\tbetween\tthe\tbrain\tand\thormone-secreting\tglands.\tThe\thypothalamus\nand\tpituitary\tgland\tdirect\thormone\tproduction,\tincluding\tthat\tof\n\tthe\tthyroid.\tWhen\tthe\nhypothalamus\tand\tpituitary\tweaken\tbecause\tof\tchroni... | [
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communicate\twell\twith\tthe\tthyroid\tgland.\n•\t\nIncreases\tthyroid-binding\tprotein\tactivity,\tso\tthat\tthyroid\thormones\tcannot\tget\tinto\tcells\tto\ndo\ttheir\tjob.\n•\t\nHampers\tthe\tconversion\tof\tT\n4\n\tto\tactive\tforms\tof\tT\n3\n,\twhich\tcan\tlead\tto\tfatigue.\n•\t\nInterferes\twith\tthe\tbiotransf... | [
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pathways\tthrough\twhich\tthyroid\nhormones\texit\tthe\tbody,\tleading\tto\tthyroid\thormone\timbalance.\n•\t\nCauses\tcells\tto\tlose\tsensitivity\tto\tthyroid\thormones.\n•\t\nWeakens\tthe\timmune\tbarriers\tof\tthe\tdigestive\ttract,\tlungs,\tand\tbrain;\tpromotes\tpoor\nimmune\tregulation.\nThe\timpact\tof\thigh\ts... | [
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decrease\tin\tthe\tnumber\tof\t\nBifidobacteria\n\tand\t\nLactobacilli\n\twas\treported.\tConversely,\tan\tincrease\tin\nthe\tnumber\tof\t\nEscherichia\tcoli\n\tand\tenterobacteria\twere\talso\treported,\tsuggesting\tthat\tthe\tincreased\nchronic\tstress\tdisrupts\tintestinal\tmicroflora\tecology.\tThe\tauthors\tpropos... | [
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increased\tpermeability\tof\tthe\tgut,\tallowing\tbacteria\tand\tbacterial\tantigens\tto\tcross\tthe\tepithelial\nbarrier\tand\tactivate\ta\tmucosal\timmune\tresponse,\n\twhich\tin\tturn\talters\tthe\tcomposition\tof\tthe\nmicrobiome\tand\tleads\tto\tenhanced\thypothalamic-pituitary-adrenal\t(HPA)\tactivation\t(\nDinan... | [
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Dinan\tand\nCryan,\t2012\n).\nThese\tare\tsome\tof\tthe\tways\tadrenal\tstress\tdirectly\taffect\tthyroid\tfunction\t(\nHerman\tet\tal,\t2016\n).\nChronic\tadrenal\tstress\taffects\tother\tsystems\tof\tthe\tbody,\twhich\tin\tturn\tdecreases\tthyroid\tfunction.\nFor\texample,\tthe\tadrenal\thormone\t\ncortisol\n\tplays\... | [
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cortisol\n\tplays\n\ta\tlarge\trole\tin\tthyroid\thealth.\tCortisol\tis\ta\tlife-\nsustaining\thormone\tessential\tto\tthe\tmaintenance\tof\thomeostasis.\tIt\toften\tis\tcalled\tthe\t“stress\nhormone”\tbecause\tit\tinfluences,\tregulates,\tor\tmodulates\tmany\tof\tthe\tchanges\tthat\toccur\tin\tthe\tbody\nin\tresponse\... | [
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•\t\nAntiinflammatory\tactions\n•\t\nBlood\tglucose\tlevels\n•\t\nBlood\tpressure\n•\t\nCentral\n\tnervous\tsystem\tactivation\n•\t\nFat,\tprotein,\tand\tcarbohydrate\tmetabolism\tto\tmaintain\tblood\tglucose\n•\t\nHeart\tand\tblood\tvessel\ttone\tand\tcontraction\n•\t\nImmune\tresponses\nCortisol\tlevels\tfollow\ta\tc... | [
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peaking\tat\tabout\t8\ta.m\tand\treaching\ta\tlow\tat\tabout\t4\tp.m\t(\nAllen\tJr,\t2013\n).\tIt\tis\tvery\timportant\tthat\nbodily\tfunctions\tand\tcortisol\tlevels\n\treturn\tto\tnormal\tafter\ta\tstressful\tevent.\tAdrenal\tfatigue\tappears\nto\toccur\twhen\tthe\tamount\tof\tstress\tor\tcombined\tstresses\toverexte... | [
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compensate\tfor\tand\trecover\tfrom\tthat\tstress.\tWhen\tthis\thappens\trepeatedly,\tit\texhausts\tthe\tadrenal | [
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and\tthyroid\tglands,\tas\twell\tas\tthe\thypothalamus\tand\tthe\tpituitary\tgland.\tOver\ttime\tthis\texhaustion\nleads\tto\tfunctional\thypothyroidism.\n\tIn\taddition,\tconstant\tcortisol\tproduction\tincreases\trisk\tfor\nobesity\tand\tweakens\tthe\tgastrointestinal\t(GI)\ttract,\tmaking\tone\tmore\tsusceptible\tto... | [
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dysbiosis\t(poor\tgut\thealth),\tand\tinfection\t(\nFoster,\t2017\n;\t\nvan\tder\tValk\tet\tal,\t2018\n).\nThe\tfollowing\tinclude\tcommon\tintegrative\tinterventions\tin\tthe\ttreatment\tof\tadrenal\tfatigue\t(\nAllolio\net\tal,\t2007\n;\t\nCharmandari,\t2014\n):\n•\t\nB-complex\tvitamins\n\tto\tprovide\tcofactors\tfo... | [
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•\t\nExercise\tin\tmoderation\n•\t\nLow-glycemic\tload,\tnutrient-dense\tdiet\n•\t\nAntianxiolytic/sedative\tbotanicals\t(i.e.\tchamomile\tand\tlavender)\t(\nHead\tand\tKelly,\t2009\n).\n•\t\nProbiotics\n•\t\nOptimizing\tsleep\thabits\n•\t\nRelaxation\tand\tstress\tmanagement\nOvert\tstressors\tsuch\tas\tchildhood\temo... | [
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0.053... |
result\tin\n\tcortisol\thyperactivity,\tthus\tleading\tto\tpituitary\tand\tadrenal\thyperreactivity\tand\tadrenal\nfatigue\tand\tdecompensation\t(\nRasmusson\tet\tal,\t2001\n).\tIncreased\tcortisol\tsignaling,\thowever,\thas\nbeen\tshown\tto\tbe\tneurocognitively\tbeneficial\tin\tdepressed\twomen\twith\ta\thistory\tof\... | [
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(\nAbercrombie\tet\tal,\t2018\n).\nCLINICAL\tCASE\tSTUDY\nFrank\tis\ta\t72-year-old\tblack\tman\tfrom\tJamaica\twho\tmoved\tto\tthe\n\tUnited\tStates\t2\tyears\tago.\tHe\nhas\tbeen\tdiagnosed\twith\thypothyroidism\tthis\tpast\tyear.\tHe\tcomes\tto\tyour\tclinic\ttaking\tSynthroid,\ngarlic,\tand\tchamomile.\tHis\tdiet\t... | [
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pepper,\tmango,\tand\tpapaya.\tHe\tstates\tthat\the\thas\tbeen\tvery\ttired\tlately,\thas\tlittle\tenergy,\tand\thas\nconstipation.\tHis\thormone\tlevels\ton\this\tlast\tmedical\treport\twere\tthyroxine\t(T\n4\n):\t1.7\tng/dL,\ntriiodothyronine\t(T\n3\n):\t75\tng/dL,\tand\tthyroid-stimulating\thormone\t(TSH):\t6\tU/mL,... | [
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0.056142374873161316,
0.1147564947605133,
-0.06192829832434654,
-0.00402873707935214,
0.10295972228050232,
-0.03876900300383568,
0.05074770748615265,
0.03483665... |
his\thypothyroidism\tis\tstill\tnot\twell\tcontrolled.\nNutrition\tdiagnostic\tstatement\n•\t\nFood-medication\tinteraction\trelated\tto\tmixing\tSynthroid\twith\tfoods\tand\therbs\tthat\taggravate\nthyroid\tdysfunction\tas\tevidenced\tby\tfatigue,\tconstipation,\thigh\tTSH,\tand\tlow\tserum\tT\n3\n\tand\nT\n4\n.\nNutr... | [
0.03891173377633095,
-0.015524684451520443,
0.04280402511358261,
-0.04362987354397774,
-0.05150081589818001,
0.032075896859169006,
0.12959393858909607,
0.06603372097015381,
-0.08034329861402512,
0.05929635465145111,
0.07972205430269241,
-0.0003207977279089391,
0.01822826638817787,
0.017861... |
3\n\tand\nT\n4\n.\nNutrition\n\tcare\tquestions\n1.\t\nWhat\tother\tinformation\tdo\tyou\tneed\tfor\ta\tmore\tthorough\tassessment?\n2.\t\nTaking\tinto\tconsideration\this\tJamaican\theritage,\tadvice\twould\tyou\toffer\tFrank\tabout\this\ndiet?\n3.\t\nWhat\tfoods\tand\tsupplements\tconflict\twith\tSynthroid?\n4. | [
0.0306391604244709,
-0.028936173766851425,
0.0637081116437912,
-0.04527889937162399,
-0.07206159085035324,
0.020394431427121162,
0.12541761994361877,
-0.005578523501753807,
-0.09201904386281967,
0.06842104345560074,
0.11698482930660248,
-0.05204451456665993,
0.01316490676254034,
0.00888806... |
diet?\n3.\t\nWhat\tfoods\tand\tsupplements\tconflict\twith\tSynthroid?\n4.\t\nBecause\the\tis\ta\trecent\timmigrant,\twhat\tpotential\tstressors\tmay\the\tbe\texperiencing?\nUseful\twebsites\nAmerican\tAssociation\tof\tClinical\n\tEndocrinologists\nAmerican\tThyroid\tAssociation\nEndocrine\tWeb\nThyroid\tDisease\tInfor... | [
0.011684519238770008,
-0.032646436244249344,
0.07123096287250519,
0.05495309457182884,
-0.032207515090703964,
0.009105644188821316,
0.08652044832706451,
-0.0050710770301520824,
-0.10748106241226196,
0.01853501982986927,
0.11119284480810165,
-0.07738412916660309,
-0.05528933182358742,
-0.04... |
References\nAbercrombie\tHC,\tFrost\tCP,\tWalsh\tEC.\tet\tal.\t\nNeural\tsignaling\tof\tcortisol,\tchildhood\temotional\nabuse\tand\tdepression-related\tmemory\tbias\n\tBiol\tPsychiatry\tCogn\tNeurosci\tNeuroimaging\n2018;3:\t274-284.\nAllen\tLV\tJr.\t\nAdrenal\tfatigue\n\tInt\tJ\tPharm\tCompd\t2013;17:\t39-44.\nAlloli... | [
-0.034557707607746124,
0.04530646651983261,
0.010000334121286869,
-0.0478457510471344,
-0.08880151063203812,
0.011104509234428406,
0.04043510556221008,
0.04689311981201172,
0.004295748192816973,
-0.0014566162135452032,
0.07957185059785843,
-0.05451270565390587,
0.03847067803144455,
-0.0008... |
Int\tJ\tPharm\tCompd\t2013;17:\t39-44.\nAllolio\tB,\tArlt\tW,\tHahner\tS.\t\nDHEA:\twhy,\twhen,\tand\thow\tmuch-DHEA\treplacement\tin\tadrenal\ninsufficiency\n\tAnn\tEndocrinol\t(Paris)\t2007;68:\t268-273.\nAmbali\tSF,\tOrieji\tC,\tAbubakar\tWO.\tet\tal.\t\nAmeliorative\teffect\tof\tVitamin\tC\ton\talterations\tin | [
-0.05269259959459305,
0.020651934668421745,
-0.020247353240847588,
-0.021490292623639107,
-0.0442231111228466,
0.021039769053459167,
0.035498183220624924,
0.08875822275876999,
-0.013936473056674004,
0.007579333148896694,
0.06497735530138016,
-0.09863152354955673,
-0.05293646082282066,
0.01... |
Ameliorative\teffect\tof\tVitamin\tC\ton\talterations\tin\nthyroid\thormone\tconcentrations\tinduced\tby\tsub-chronic\tCo-administration\tof\tChloropyrifos\nand\tLead\tin\twistar\trats\n\tJ\tThyroid\tRes\t2011;\t214924.\nAmerican\tThyroid\tAssociation:\t\nThyroid\tdisease\tand\n\tpregnancy\n\t(website).\nhttp://www.thy... | [
-0.019533922895789146,
-0.08443169295787811,
0.02019534632563591,
-0.0413893386721611,
-0.021867338567972183,
0.03165816888213158,
0.07547173649072647,
0.0764564722776413,
-0.040870144963264465,
0.06711778044700623,
0.05210413411259651,
-0.044199418276548386,
0.016685305163264275,
-0.01750... |
(website).\nhttp://www.thyroid.org/thyroid-disease-and-pregnancy/\n.\nAmin\tAl,\tHegazy\tNM,\tIbrahim\tKS.\tet\tal.\t\nThyroid\thormone\tindices\tin\tcomputer\tworkers\twith\nemphasis\ton\tthe\trole\tof\tZinc\tsupplementation\n\tOpen\tAccess\tMaced\tJ\tMed\tSci\t2016;4:\t296-301.\nBaeke\tF,\tTakiishi\tT,\tKorf\tH.\tet\... | [
-0.02882264368236065,
-0.06364750117063522,
0.0004036717291455716,
-0.0723630040884018,
0.013846301473677158,
0.007769026327878237,
0.011601374484598637,
0.07074154913425446,
-0.03884578496217728,
0.025421202182769775,
0.0718161016702652,
-0.029518745839595795,
0.026659585535526276,
-0.048... |
Vitamin\tD:\tmodulator\tof\tthe\timmune\tsystem\n\tCurr\tOpin\nPharmacol\t2010;10:\t482-496.\nBajaj\tJK,\tSalwan\tP,\n\tSalwan\tS.\t\nVarious\tpossible\ttoxicants\tinvolved\tin\tthyroid\tdysfunction:\ta\nreview\n\tJ\tClin\tDiagn\tRes\t2016;10:\tFE01-\tFE03.\nBarker\tJM,\tLiu\tE.\t\nCeliac\tdisease:\tpathophysiology,\tc... | [
-0.05012090131640434,
-0.07275602221488953,
0.028092794120311737,
-0.029678912833333015,
-0.08245640248060226,
0.00382475508376956,
0.10219275951385498,
0.09829238802194595,
-0.06614150106906891,
0.05665102228522301,
0.06128162518143654,
-0.026789816096425056,
0.03368440270423889,
0.044397... |
autoimmune\tconditions\n\tAdv\tPediatr\t2008;55:\t349-365. | [
-0.07702507823705673,
0.03430662304162979,
0.01141584012657404,
0.023389264941215515,
-0.060200031846761703,
0.005191479809582233,
0.13800638914108276,
0.11149469763040543,
-0.043347373604774475,
0.04106510058045387,
-0.0019130985019728541,
-0.04587247967720032,
-0.00845007412135601,
0.059... |
31\nMedical\tnutrition\ttherapy\tfor\nanemia\nMichelle\tLoy,\tMPH,\tMS,\tRDN\nKEY\tTERMS\nanemia\naplastic\tanemia\nceruloplasmin\nferritin\nferroprotein\nglossitis\nhematocrit\nheme\tiron\nhemoglobin\nhemolytic\tanemia\nhepcidin\nhereditary\themochromatosis\nolotranscobalamin\tII\t(holo\tTCII)\nhypochromic\nintrinsic\... | [
-0.02355860359966755,
-0.039623744785785675,
-0.06860968470573425,
-0.024418631568551064,
-0.07679207623004913,
-0.0018960919696837664,
0.05705110728740692,
0.08600761741399765,
-0.07717958092689514,
0.08336753398180008,
0.03969850763678551,
-0.014053475111722946,
0.017883284017443657,
-0.... |
iron\tdeficiency\tanemia\nkoilonychia\nmacrocytic\tanemia\nmeat-fish-poultry\n\t(MFP)\tfactor\nmegaloblastic\tanemia\nmicrocytic\tanemia\nnonheme\tiron\nnormochromic\nnutritional\tanemias\npagophagia\npernicious\tanemia\npica\nplasma\npolycythemia\nprotoporphyrin\nreticulocytosis\nrestless\tlegs\tsyndrome\t(RLS)\nserum... | [
0.006749071180820465,
-0.0055512902326881886,
-0.032011616975069046,
0.06303142011165619,
-0.03284000977873802,
0.015274643898010254,
0.06188461184501648,
0.04888046905398369,
-0.06282808631658554,
0.058140840381383896,
0.01830364018678665,
-0.0457676462829113,
-0.010648338124155998,
-0.00... |
restless\tlegs\tsyndrome\t(RLS)\nserum\nsickle\tcell\tdisease\t(SCD)\nsideroblastic\t(pyridoxine-responsive)\tanemia\nsoluble\tserum\ttransferrin\treceptors\t(STFRs)\nsports\tanemia\nthalassemia\ntotal\tiron-binding\n\tcapacity\t(TIBC) | [
-0.008275034837424755,
-0.07652731984853745,
-0.015693800523877144,
0.0714181587100029,
-0.06745395064353943,
0.026005486026406288,
0.05296717584133148,
0.09618343412876129,
0.017346495762467384,
0.0464666485786438,
0.019046762958168983,
0.009855542331933975,
0.04295094683766365,
0.0663896... |
transferrin\ntransferrin\treceptor\ntransferrin\tsaturation\nAnemia\n\tis\tthe\tpredominant\thematologic\tdisorder\tin\tthe\tUnited\tStates\tand\tis\tassociated\twith\tmedical\nconsequences\tthat\tinfluence\tmorbidity\tand\tmortality.\tAnemia\taffects\t5.6%\tof\tthe\tnation’s\tpopulation\nwith\tthe\tprevalence\tbeing\t... | [
0.01692529208958149,
-0.06341514736413956,
0.03206423670053482,
-0.023604298010468483,
-0.07920827716588974,
0.016787923872470856,
0.08472071588039398,
0.049415796995162964,
-0.00963179487735033,
0.06033217906951904,
0.08633749932050705,
-0.01233004406094551,
-0.02311771735548973,
0.008788... |
blacks,\tand\tHispanics\t(\nLe,\t2016\n).\tAnemia\tis\talso\ta\tserious\tglobal\thealth\tburden\taffecting\t2\tbillion\npeople\tworldwide\twith\tthe\thighest\trates\toccurring\tin\tSouth\tAsia\tand\tcentral\tand\twest\tsub-Saharan\nAfrica\t(\nKassebaum,\t2016\n).\tGlobally,\tyoung\tchildren,\twomen,\tand\tolder\tadults... | [
0.03978945314884186,
-0.0008108566980808973,
0.06846848875284195,
-0.027172645553946495,
-0.08962010592222214,
-0.022805161774158478,
0.08299748599529266,
-0.06106440722942352,
-0.0232873372733593,
0.0805586576461792,
0.08151485025882721,
-0.09232351928949356,
-0.03200292959809303,
-0.0187... |
developing\tanemia.\tTo\tbest\taddress\tthis\tserious\thealth\tproblem,\tnutrition\tprofessionals\tneed\ta\tsolid\nunderstanding\tof\tthe\trelevant\tterminology\n\talong\twith\tthe\tetiology,\tpathophysiology,\tand\tmedical\tand\nnutritional\tmanagement\tof\tthe\tmost\tcommon\ttypes\tof\tanemia.\nHemoglobin | [
0.04465549439191818,
-0.006780114956200123,
-0.017444510012865067,
0.018031002953648567,
-0.06846743077039719,
0.01788940839469433,
0.09124203771352768,
0.05066100135445595,
-0.07782184332609177,
0.07131471484899521,
0.04732625186443329,
-0.0343359149992466,
-0.05279361456632614,
0.0104731... |
nutritional\tmanagement\tof\tthe\tmost\tcommon\ttypes\tof\tanemia.\nHemoglobin\n\tis\ta\tconjugated\tprotein\tcontaining\tfour\theme\tgroups\tand\tglobin;\tit\tis\tthe\toxygen-\ncarrying\tpigment\tof\tthe\terythrocytes.\tThe\t\nhematocrit\n\tis\tthe\tvolume\tpercentage\tof\terythrocytes\tin\nthe\tblood.\t\nPlasma\n\tis... | [
-0.0266107190400362,
-0.04052178934216499,
-0.01452681701630354,
-0.016660109162330627,
-0.0778941884636879,
0.0608200766146183,
0.1015208289027214,
0.04469125717878342,
-0.04352642968297005,
0.07345952838659286,
0.05086464062333107,
-0.021689148619771004,
0.005328531842678785,
0.014468194... |
serum\n\tis\tthe\nliquid\tportion\tof\twhole\tblood\twithout\tcoagulation\tfactors.\nAnemia\tis\ta\tdeficiency\tin\tthe\tsize\tor\tnumber\tof\tred\tblood\tcells\t(RBCs)\tor\tthe\tamount\tof\themoglobin\nthey\tcontain.\tThis\tdeficiency\tlimits\tthe\texchange\tof\toxygen\tand\tcarbon\tdioxide\tbetween\tthe\tblood | [
0.014980653300881386,
-0.09016953408718109,
-0.019187897443771362,
-0.013750431127846241,
-0.05671478435397148,
0.03764953836798668,
0.1141093298792839,
0.08949849009513855,
-0.034627944231033325,
0.047538623213768005,
0.0714837908744812,
-0.04042994976043701,
0.008249797858297825,
0.05129... |
and\tthe\ttissue\tcells.\tAnemia\tclassification\tis\tbased\ton\tcell\tsize—macrocytic\t(large),\tnormocytic\n(normal),\tand\tmicrocytic\t(small)—and\n\ton\themoglobin\tcontent:\t\nhypochromic\n\t(pale\tcolor\tfrom\ndeficiency\tof\themoglobin)\tand\t\nnormochromic\n\t(normal\tcolor)\t(\nTable\t31.1\n). | [
0.006495624780654907,
-0.03149239346385002,
-0.0019733007065951824,
-0.01862781122326851,
-0.062036819756031036,
0.0068758949637413025,
0.08285417407751083,
0.11749032884836197,
-0.04248809814453125,
0.06810430437326431,
0.07154520601034164,
-0.040227845311164856,
-0.0462564118206501,
0.05... |
TABLE\t31.1\nMorphologic\tClassification\tof\tAnemia\nMorphologic\nType\tof\nAnemia\nUnderlying\nAbnormality\nClinical\tSyndromes\nTreatment\nMacrocytic\t(MCV\t>\t94;\tMCHC\t>\t31)\nMegaloblastic\nVitamin\tB\n12\ndeficiency\nPernicious\tanemia\nVitamin\tB\n12\nFolate\tdeficiency\nNutritional\tmegaloblastic\nanemias,\tm... | [
-0.013679643161594868,
-0.05664554983377457,
0.004770007450133562,
-0.006728406064212322,
-0.04815620929002762,
-0.007686343975365162,
0.03288722783327103,
0.11204192787408829,
-0.09954000264406204,
0.04033161699771881,
0.05957632139325142,
-0.008464806713163853,
0.013944264501333237,
-0.0... |
anemias,\tmalabsorption\nsyndromes\nFolic\tacid\nInherited\ndisorders\tof\nDNA\tsynthesis\nOrotic\taciduria\nSickle\tcell\tdisease\nTreatment\tbased\ton\tthe\tnature\tof\nthe\tdisorder\nDrug-induced\ndisorders\tof\nDNA\tsynthesis\nSide\teffects\tof\nchemotherapeutic\tagents,\nanticonvulsants,\toral\ncontraceptives\nDis... | [
-0.05105661600828171,
-0.07075865566730499,
0.012166633270680904,
0.005612404551357031,
-0.08782227337360382,
0.020174872130155563,
0.008913329802453518,
0.03679044172167778,
-0.047540225088596344,
0.10498882830142975,
0.11931120604276657,
-0.021802393719553947,
0.02465750277042389,
0.0114... |
contraceptives\nDiscontinue\toffending\tdrug\tand\nadminister\tfolic\tacid\nNonmegaloblastic\nAccelerated\nerythropoiesis\nHemolytic\tanemia\nTreatment\tof\tunderlying\tdisease\nHypochromic\tMicrocytic\t(MCV\t<\t80;\tMCHC\t<\t31)\nIron\tdeficiency\nChronic\tloss\tof\n\tblood,\ninadequate\tdiet,\timpaired\nabsorption,\t... | [
-0.05527243763208389,
-0.09805100411176682,
-0.013231396675109863,
0.025109170004725456,
-0.09361939132213593,
0.025105809792876244,
0.07241592556238174,
0.11387529224157333,
-0.027894441038370132,
0.0955023318529129,
0.11191465705633163,
0.005266943946480751,
-0.010425141081213951,
0.0328... |
absorption,\tincreased\ndemands\nFerrous\tsulfate\tor\tferrous\tbis\nglycinate\tand\tcorrection\tof\nunderlying\tcause\nDisorders\tof\nglobin\nsynthesis\nThalassemia\nHemoglobin\tE\nHemoglobin\tC\nNonspecific\nMild\t–\tdoes\tnot\trequire\ntreatment;\nSevere\t–\tfrequent\tblood\ntransfusions\tto\tprovide\nhealthy\tRBCs\... | [
-0.013489124365150928,
-0.1074841320514679,
0.012722715735435486,
0.000329935661284253,
-0.06970564275979996,
0.015619768761098385,
0.09658654779195786,
0.03062228485941887,
-0.019031034782528877,
0.10880652815103531,
0.059450846165418625,
-0.01952384226024151,
-0.013626361265778542,
0.060... |
Hgb\nDisorders\tof\nporphyrin\tand\nheme\nsynthesis\nPyridoxine-responsive\n\tanemia\nPyridoxine\nOther\tdisorders\nof\tiron\nmetabolism\nCopper\tdeficiency\nCopper\nNormochromic\tNormocytic\t(MCV\t82-92;\tMCHC\t>\t30)\nRecent\tblood\tloss\nVarious\nTransfusion,\tiron,\tcorrection\tof\nunderlying\tcondition\nOverexpans... | [
-0.046171609312295914,
-0.07017440348863602,
-0.0011755459709092975,
-0.010451334528625011,
-0.0502234548330307,
0.018893275409936905,
0.018088605254888535,
0.09504145383834839,
-0.0499810166656971,
0.05644308775663376,
0.0888184905052185,
-0.020277660340070724,
0.01655956543982029,
0.0261... |
Overexpansion\tof\nplasma\tvolume\nEdema\tof\tpregnancy\nRestore\thomeostasis\nHemolytic\ndiseases\nOverhydration\nTreatment\tbased\ton\tthe\tnature\tof\nthe\tdisorder\nHypoplastic\tbone\nmarrow\nAplastic\tanemia\nPure\tRBC\taplasia\nTransfusion\nAndrogens\nInfiltrated\tbone\nmarrow\nLeukemia,\tmultiple\tmyeloma,\nmyel... | [
-0.038676392287015915,
-0.04754521697759628,
0.04387002810835838,
-0.013720687478780746,
-0.0877237617969513,
-0.014345028437674046,
0.024981750175356865,
0.10522833466529846,
-0.06439446657896042,
0.10137128084897995,
0.03278928995132446,
0.03727325052022934,
0.042301297187805176,
-0.0083... |
myelofibrosis\nChemotherapy\nEndocrine\nabnormality\nHypothyroidism,\tadrenal\ninsufficiency\nTreatment\tof\tunderlying\tdisease\nChronic\tdisease\nTreatment\tof\tunderlying\tdisease\nRenal\tdisease\nRenal\tdisease\nTreatment\tof\tunderlying\tdisease\nLiver\tdisease\nCirrhosis\nTreatment\tof\tunderlying\n\tdisease\nDNA... | [
-0.03752022609114647,
-0.061193305999040604,
0.025562673807144165,
-0.038314253091812134,
-0.10243258625268936,
0.00020106435113120824,
-0.008306284435093403,
0.03682403638958931,
-0.05955931544303894,
0.13278985023498535,
0.08645753562450409,
0.007597777526825666,
0.020188087597489357,
0.... |
Treatment\tof\tunderlying\n\tdisease\nDNA,\n\tDeoxyribonucleic\tacid;\t\nMCHC,\n\tmean\tcorpuscular\themoglobin\tconcentration:\tconcentration\tof\themoglobin\texpressed\tin\tgrams\tper\tdeciliter\n(g/dL);\t\nMCV,\n\tmean\tcorpuscular\tvolume:\tvolume\tof\tone\tred\tblood\tcell\texpressed\tin\tfemtoliters\t(fl);\t\nRBC... | [
-0.05713033676147461,
-0.08377186208963394,
0.006017675157636404,
-0.11915150284767151,
-0.1100769191980362,
0.006551968399435282,
0.04007803648710251,
0.03600737452507019,
-0.04905932769179344,
0.06545381247997284,
0.12749305367469788,
0.02768133580684662,
0.0013024666113778949,
0.0165791... |
RBC\n,\tred\tblood\tcell.\nModified\tfrom\tWintrobe\tMM\tet\tal:\t\nClinical\thematology,\n\ted\t8,\tPhiladelphia,\t1981,\tLea\t&\tFebiger.\nMacrocytic\tanemia\n\tpresents\n\twith\tlarger-than-normal\tRBCs,\tplus\tincreased\tmean\tcorpuscular\nvolume\t(MCV)\tand\tmean\tcorpuscular\themoglobin\tconcentration\t(MCHC).\t\... | [
-0.04637422785162926,
-0.105244480073452,
-0.0631503313779831,
0.005935076158493757,
-0.06218620017170906,
0.010088678449392319,
0.0494559071958065,
0.11516962945461273,
-0.04957141727209091,
0.048620205372571945,
0.032948967069387436,
-0.02546798065304756,
-0.030756818130612373,
0.0304350... |
Microcytic\tanemia\n\tis\ncharacterized\tby\tsmaller-than-normal\terythrocytes\tand\tless\tcirculating\themoglobin,\tas\tin\tiron\ndeficiency\tanemia\tand\tthalassemia.\nMost\tanemias\tare\tcaused\tby\ta\tlack\tof\tnutrients\trequired\tfor\tnormal\terythrocyte\tsynthesis,\nprincipally\tiron,\tvitamin\tB\n12\n,\tand\tfo... | [
0.005166747607290745,
-0.032528653740882874,
0.002665318548679352,
0.004787136800587177,
-0.04809881001710892,
0.014466896653175354,
0.08826003968715668,
0.05006806552410126,
-0.06615486741065979,
0.06316520273685455,
0.050782471895217896,
-0.04857407510280609,
0.011316796764731407,
0.0481... |
protein,\tcertain\tvitamins,\tcopper,\tand\tother\theavy\tmetals\tare\tcalled\t\nnutritional\tanemias\n.\tOther\nanemias\tresult\tfrom\tconditions\tsuch\tas\themorrhage,\tgenetic\tabnormalities,\tchronic\tdisease\tstates, | [
-0.011111285537481308,
-0.07213131338357925,
0.015462329611182213,
0.026397932320833206,
-0.05374899506568909,
0.06401332467794418,
0.09155330061912537,
0.04961824789643288,
-0.05408719182014465,
0.06109188124537468,
0.04290812090039253,
-0.06664049625396729,
-0.028538232669234276,
0.05276... |
or\tdrug\ttoxicity\tand\thave\tvarying\tdegrees\tof\tnutritional\tconsequence.\nIron-related\tblood\tdisorders\nIron\tstatus\tcan\trange\tfrom\n\toverload\tto\tdeficiency\tand\tanemia.\tRoutine\tmeasurement\tof\tiron\tstatus\tis\nnecessary\tbecause\tapproximately\t6%\tof\tAmericans\thave\ta\tnegative\tiron\tbalance,\ta... | [
-0.007979409769177437,
-0.06782520562410355,
0.0038180341944098473,
-0.00012599823821801692,
-0.0723315179347992,
0.0009877571137621999,
0.06753472983837128,
0.04250817745923996,
-0.039649784564971924,
0.030476737767457962,
0.11917701363563538,
-0.024035464972257614,
-0.013268624432384968,
... |
have\ta\tgene\tfor\tpositive\tbalance\tand\tincreased\tstorage\tof\tiron,\tand\tapproximately\t1%\thave\tiron\noverload.\tAnemia\talso\taffects\tsome\tgroups\tmore\tthan\tothers.\tNon-Hispanic\tblacks\tand\tHispanics\nhave\tthe\thighest\tprevalence\tof\tanemia\n\tfollowed\tby\tnon-Hispanic\twhites.\tAs\tshown\tin\t\nFi... | [
0.04329146817326546,
-0.012378606013953686,
0.050338875502347946,
0.012095090933144093,
-0.047734055668115616,
0.024532973766326904,
0.08593200147151947,
-0.028234019875526428,
-0.0702383741736412,
0.030498884618282318,
0.14418265223503113,
-0.0788465216755867,
-0.051158152520656586,
-0.01... |
followed\tby\tnon-Hispanic\twhites.\tAs\tshown\tin\t\nFig.\t31.1\n,\nstages\tof\tiron\tstatus\trange\tfrom\tiron\toverload\tto\tiron\tdeficiency\tanemia\tand\tare\tsummarized\tas\nfollows\t(\nHerbert,\t1992\n):\na.\t\nStage\tI\tand\tstage\tII\tnegative\tiron\tbalance\t(i.e.,\tiron\tdepletion).\tIn\tthese\tstages\tiron\... | [
-0.004316908307373524,
-0.021334072574973106,
0.014851084910333157,
-0.038302864879369736,
-0.05912155658006668,
0.023320117965340614,
0.06340614706277847,
0.018747903406620026,
-0.02922179363667965,
0.028480038046836853,
0.13597038388252258,
-0.05013168230652809,
-0.014739135280251503,
0.... |
are\tlow\tand\tthere\tis\tno\tdysfunction.\tIn\tstage\tI\tnegative\tiron\tbalance,\treduced\tiron\nabsorption\tproduces\tmoderately\tdepleted\n\tiron\tstores.\tStage\tII\tnegative\tiron\tbalance\tis\ncharacterized\tby\tseverely\tdepleted\tiron\tstores.\nb.\t\nStage\tIII\tand\tstage\tIV\tnegative\tiron\tbalance\t(i.e.,\... | [
-0.0000748107850085944,
-0.04296976700425148,
0.020177459344267845,
-0.05312824621796608,
-0.08429761230945587,
-0.019524382427334785,
0.08127905428409576,
0.008071597665548325,
-0.020277054980397224,
0.06332645565271378,
0.08352585881948471,
-0.02357497811317444,
0.03648991510272026,
0.08... |
characterized\tby\tinadequate\tbody\tiron,\tpossibly\tcausing\tdysfunction\tand\tdisease.\tIn\tstage\tIII\nnegative\tiron\tbalance,\tdysfunction\tis\tnot\taccompanied\tby\tanemia;\tanemia\tdevelops\tin\tstage\nIV\tnegative\tiron\tbalance.\nc.\t\nStage\tI\tand\tstage\tII\tpositive\tiron\tbalance.\tStage\tI\tpositive\tba... | [
0.04078690707683563,
-0.03836812451481819,
0.027700770646333694,
-0.0329691581428051,
-0.11046455055475235,
0.006692058872431517,
0.08167038857936859,
0.03562193736433983,
-0.027744164690375328,
0.06623836606740952,
0.09361618757247925,
-0.05740063637495041,
0.011891970410943031,
0.0632071... |
years\twith\tno\tdysfunction.\tSupplements\tof\tiron\tand/or\tvitamin\tC\tpromote\tprogression\tto\ndysfunction\tor\tdisease,\twhereas\tiron\tremoval\tprevents\tprogression\tto\tdisease.\tIron\toverload\ndisease\tdevelops\tin\tpersons\twith\tstage\tII\tpositive\tbalance\tafter\tyears\tof\tiron\toverload\thave\ncaused\t... | [
-0.035874657332897186,
-0.029523741453886032,
0.024093206971883774,
-0.06870377063751221,
-0.07335928827524185,
-0.00395927345380187,
0.03546467795968056,
0.02148415520787239,
-0.02514616586267948,
0.059650808572769165,
0.10221055895090103,
-0.00392912095412612,
0.06430457532405853,
0.0063... |
caused\tprogressive\tdamage\n\tto\ttissues\tand\torgans.\nFIG.\t31.1\nSequential\tstages\tof\tiron\tstatus.\t\nIBC\n,\tIron-binding\tcapacity;\t\nRBC\n,\tred\tblood\tcell;\t\nRE\n,\nreticuloendothelial\tcells.\n\tSource:\t(Copyright\tVictor\tHerbert,\t1995.)\nIron\tstatus\thas\ta\tvariety\tof\tindicators.\tSerum\t\nfer... | [
-0.0939282774925232,
-0.007130248472094536,
0.028916537761688232,
-0.0745503157377243,
-0.07371143996715546,
0.01999424211680889,
0.04406068101525307,
0.05454372987151146,
0.016960466280579567,
0.07533037662506104,
0.07286971062421799,
-0.005440134555101395,
0.011900841258466244,
0.0044015... |
ferritin\n\tis\tan\tiron\tapoferritin\tcomplex,\tone\tof\tthe\nchief\tstorage\tforms\tof\tiron.\tSerum\tferritin\tlevels\tare\tin\tequilibrium\twith\tbody\tiron\tstores.\tVery\tearly\n(stage\tI)\tpositive\tiron\n\tbalance\tmay\tbest\tbe\trecognized\tby\tmeasuring\t\ntotal\tiron-binding\tcapacity\n(TIBC)\n,\tthe\tcapaci... | [
-0.03951261565089226,
-0.07729041576385498,
0.016572993248701096,
-0.04114481806755066,
-0.11159930378198624,
0.021991202607750893,
0.05553857609629631,
0.008089535869657993,
0.00767305726185441,
0.04336864873766899,
0.026463711634278297,
-0.009247889742255211,
0.06291594356298447,
0.02891... |
measurement\tof\tserum\tor\tplasma\tferritin\tlevels\tmay\tbest\treveal\tearly\t(stages\tI\tor\tII)\tnegative\tiron\nbalance,\talthough\tserum\tTIBC\tmay\tbe\tas\tgood\tan\tindicator\t(see\t\nChapter\t5\n).\t\nTransferrin\tsaturation\nis\tthe\tmeasure\tof\tthe\tamount\tof\tiron\n\tbound\tto\ttransferrin\tand\tis\ta\tga... | [
-0.010138342157006264,
-0.06466903537511826,
0.04906264320015907,
-0.03566389158368111,
-0.12384707480669022,
-0.008077774196863174,
0.06644361466169357,
0.004908639006316662,
0.018010703846812248,
0.06791645288467407,
0.08595200628042221,
-0.019384095445275307,
0.03641655296087265,
0.0477... |
bound\tto\ttransferrin\tand\tis\ta\tgauge\tof\tiron\tsupply\tto\tthe\ttissues;\nthe\tpercent\tsaturation\t=\tserum\tiron/TIBC\t×\t100.\nIron\tdeficiency\tanemia\nPathophysiology\nIron\tdeficiency\tanemia\n\tis\tcharacterized\tby\tthe\tproduction\tof\tmicrocytic\terythrocytes\tand\ta | [
0.0006213432061485946,
-0.05586446449160576,
-0.013923010788857937,
-0.008484615944325924,
-0.07950275391340256,
0.023262564092874527,
0.05645502731204033,
0.09093662351369858,
-0.029687460511922836,
0.031079662963747978,
0.05897486209869385,
-0.02743501216173172,
-0.014474169351160526,
0.... |
diminished\tlevel\tof\tcirculating\themoglobin.\tThis\tmicrocytic\tanemia\tis\tthe\tlast\tstage\tof\tiron\ndeficiency,\tand\tit\trepresents\tthe\tend\tpoint\tof\ta\tlong\n\tperiod\tof\tiron\tdeprivation.\tThere\tare\tmany\ncauses\tof\tiron\tdeficiency\tanemia\tas\tdiscussed\tin\t\nBox\t31.1\n.\nBOX\t31.1\nCauses\tof\tI... | [
0.05097372457385063,
-0.03842668607831001,
0.023048309609293938,
0.0025299370754510164,
-0.0617598332464695,
0.017402008175849915,
0.05678312107920647,
0.0985129103064537,
-0.02679016813635826,
0.051567498594522476,
0.05418868735432625,
0.0025977063924074173,
0.00866648182272911,
0.0432717... |
.\nBOX\t31.1\nCauses\tof\tIron\tDeficiency\tAnemia\nInadeq\nuate\nInge\nstion\nPoor\tdiet\twithout\tsupplementation\tof\tiron\nInadeq\nuate\nAbso\nrptio\nn\nDiarrhea,\tachlorhydria,\tintestinal\tdisease\tsuch\tas\tceliac\tdisease,\tatrophic\tgastritis,\tpartial\tor\ntotal\tgastrectomy,\tor\tdrug\tinterference\nInadeq\nu... | [
0.004685764666646719,
-0.09264169633388519,
-0.01116197556257248,
-0.006860100664198399,
-0.08921273797750473,
-0.01642751321196556,
0.023516591638326645,
0.050805602222681046,
-0.06107582524418831,
0.043347667902708054,
0.06260042637586594,
0.03332807496190071,
0.06083797290921211,
0.0380... |
Utili\nzatio\nn\nChronic\tgastrointestinal\tdisturbances\nIncreas\ned\nReq\nuire\nment\nIncrease\tof\tblood\tvolume,\twhich\toccurs\tduring\tinfancy,\tadolescence,\tpregnancy,\tand\tlactation\nand\twhich\tis\tnot\tbeing\tmatched\twith\tintake\nIncreas\ned\nExcr\netion\nExcessive\tmenstrual\tblood\t(in\tfemales);\themor... | [
0.02387288026511669,
-0.07982504367828369,
0.021712977439165115,
0.006560286041349173,
-0.14833736419677734,
-0.00883399322628975,
0.07879818975925446,
0.02060227282345295,
0.010370033793151379,
0.09022786468267441,
0.09107358008623123,
-0.006997554562985897,
0.033629950135946274,
0.056679... |
bleeding\tulcer,\tbleeding\themorrhoids,\tesophageal\tvarices,\tregional\tenteritis,\tceliac\n\tdisease,\nCrohn’s\tdisease,\tulcerative\tcolitis,\tparasitic\tor\tmalignant\tdisease\nIncreas\ned\nDest\nructi\non\nCaused\tby\ta\tchronic\tinflammation\tor\tother\tchronic\tdisorder\tleading\tto\tdestruction\tof\tRBC’s | [
-0.003182373009622097,
-0.09911733865737915,
0.03877750411629677,
-0.01725705899298191,
-0.10932528227567673,
0.035645559430122375,
0.010583148337900639,
0.028139809146523476,
0.034614186733961105,
0.07131300866603851,
0.06284838169813156,
-0.024344436824321747,
-0.016257766634225845,
0.06... |
A\tcommon\tcause\tof\tiron\tdeficiency\tis\tblood\tloss,\teither\tchronic\tor\tacute,\tincluding\theavy\tmenstrual\nbleeding\tin\twomen.\tIt\tcan\talso\tbe\tcaused\tby\tmalabsorption,\tmedications,\tand\tinadequate\tintake.\nBecause\tanemia\tis\tthe\tlast\tmanifestation\tof\tchronic,\tlong-term\tiron\tdeficiency,\tthe\... | [
0.00446089543402195,
-0.06176307052373886,
0.058031439781188965,
-0.006544461008161306,
-0.12396480143070221,
0.0051901210099458694,
0.08565802872180939,
0.013287902809679508,
0.002403805498033762,
0.10444434732198715,
0.1022116169333458,
-0.0399160236120224,
0.014063267037272453,
0.055904... |
a\tmalfunction\tof\ta\tvariety\tof\tbody\tsystems.\tInadequate\tmuscle\tfunction\tis\treflected\tin\tdecreased\nwork\tperformance\tand\texercise\ttolerance.\tNeurologic\tinvolvement\tis\tmanifested\tby\tbehavioral\nchanges\tsuch\tas\tfatigue,\tanorexia,\tand\t\npica\n\t(consumption\tof\tnonfood\titems),\tespecially\t\n... | [
0.05346822738647461,
-0.07695548981428146,
0.05374710634350777,
0.03927988559007645,
-0.12548920512199402,
0.02411189302802086,
0.10079225152730942,
0.023339712992310524,
-0.03171338140964508,
0.07266711443662643,
0.11528279632329941,
-0.05804893374443054,
0.01304230559617281,
0.0169697925... |
(consumption\tof\tnonfood\titems),\tespecially\t\npagophagia\n(ice\teating).\n\tAbnormal\tcognitive\tdevelopment\tin\tchildren\tmay\tindicate\tiron\tdeficiency\tbefore\tit\thas\ndeveloped\tinto\tovert\tanemia\t(\nJáuregui-Lobera,\t2014\n).\nGrowth\tabnormalities,\tepithelial\tdisorders,\tand\ta\treduction\tin\tgastric\... | [
0.020385386422276497,
-0.056985076516866684,
0.04556291177868843,
0.034920092672109604,
-0.0716429203748703,
0.024625012651085854,
0.09071153402328491,
0.014171639457345009,
-0.021117962896823883,
0.09696492552757263,
0.10328333079814911,
-0.0856916680932045,
-0.0015253786696121097,
0.0384... |
possible\tsign\tof\tearly\tiron\tdeficiency\tis\treduced\timmunocompetence,\tparticularly\tdefects\tin\tcell-\nmediated\timmunity\tand\tthe\tphagocytic\tactivity\tof\tneutrophils,\n\twhich\tmay\tlead\tto\tfrequent\tinfections.\nRestless\tlegs\tsyndrome\t(RLS)\n\twith\tleg\tpain\tor\tdiscomfort\tmay\tresult\tfrom\ta\tla... | [
-0.006864973343908787,
-0.07460354268550873,
0.048735056072473526,
0.010540819726884365,
-0.09368181228637695,
0.030925801023840904,
0.065719373524189,
0.025378871709108353,
0.014166967011988163,
0.09073808789253235,
0.09770844876766205,
-0.011882243677973747,
0.04863926023244858,
0.078004... |
brain;\tthis\talters\tdopamine\tproduction\tand\tmovement\t(\nConnor\tet\tal,\t2017\n).\nAs\tiron\tdeficiency\tanemia\tbecomes\tmore\tsevere,\tdefects\tarise\tin\tthe\tstructure\tand\tfunction\tof\tthe\nepithelial\ttissues,\tespecially\tof\tthe\ttongue,\tnails,\tmouth,\tand\tstomach.\tThe\tskin\tmay\tappear\n\tpale\tin | [
0.011065864935517311,
-0.050542980432510376,
0.05157995596528053,
-0.020075691863894463,
-0.08533655852079391,
0.016941793262958527,
0.1123216301202774,
0.010192335583269596,
-0.005794045515358448,
0.09594519436359406,
0.09111979603767395,
-0.04641667753458023,
-0.01378086768090725,
0.0239... |
pale\tin\npeople\twith\tlighter\tcomplexions,\tand\tthe\tinside\tof\tthe\tlower\teyelid\tmay\tbe\tlight\tpink\tinstead\tof\tred\nregardless\tof\tskin\ttone.\tMouth\tchanges\tinclude\tatrophy\tof\tthe\tlingual\tpapillae,\tburning,\tredness,\tand\nin\tsevere\tcases,\t\nglossitis\n,\ta\tcompletely\tsmooth,\twaxy,\tand\tgl... | [
0.028301823884248734,
-0.035026177763938904,
0.08456841856241226,
-0.010163315571844578,
-0.11184111982584,
0.020814063027501106,
0.09132102131843567,
-0.022837994620203972,
-0.014806872233748436,
0.06389185786247253,
0.09894907474517822,
-0.10055746138095856,
0.01973000541329384,
0.007205... |
,\ta\tcompletely\tsmooth,\twaxy,\tand\tglistening\tappearance\tof\tthe\ttongue.\nAngular\tstomatitis\tand\ta\tform\tof\tdysphagia\tmay\toccur.\tGastritis\toccurs\tfrequently\tand\tmay\n\tresult\tin\nachlorhydria\t(low\tstomach\tacid).\tFingernails\tcan\tbecome\tthin\tand\tflat,\tand\teventually\t\nkoilonychia\n(spoon-s... | [
0.024455329403281212,
-0.06265933811664581,
0.055790551006793976,
-0.017184097319841385,
-0.12091287225484848,
-0.0249125175178051,
0.10025200992822647,
0.01397772692143917,
-0.009102091193199158,
0.04450346156954765,
0.08133026957511902,
-0.01471109502017498,
0.054882753640413284,
0.02684... |
FIG.\t31.2\nFingernails\twith\tcup-like\tdepressions\t(koilonychia)\tare\ta\tsign\tof\tiron\tdeficiency\tin\tadults.\n\tSource:\t(From\nHeitz\tC.\tKoilonychia.\tIn:\tFlickr\t[website].\t\t\nhttps://www.flickr.com/photos/coreyheitzmd/15023020192\n.\tApril\t14,\t2014.)\nProgressive,\tuntreated\tanemia\tresults\tin\tcardi... | [
-0.03937361389398575,
-0.01912267878651619,
0.0025508489925414324,
0.0016436197329312563,
-0.032974723726511,
-0.03555574268102646,
0.0911477729678154,
0.043801188468933105,
-0.03731301426887512,
0.05870725214481354,
0.12881776690483093,
-0.05127102509140968,
0.02657267078757286,
0.0573741... |
eventually\tlead\tto\tcardiac\tfailure.\tSome\tsocial\tand\temotional\tbehavioral\n\tsymptoms\trespond\tto\tiron\ntherapy\tbefore\tthe\tanemia\tis\tcured,\tsuggesting\tthey\tmay\tbe\tthe\tresult\tof\ttissue\tdepletion\tof\tiron-\ncontaining\tenzymes\trather\tthan\ta\tdecreased\tlevel\tof\themoglobin\t(\nsee\n\t\nPathop... | [
0.016350766643881798,
-0.09879098832607269,
0.02108202502131462,
-0.0029202888254076242,
-0.08244471251964569,
0.010133077390491962,
0.09897314012050629,
0.04524816945195198,
-0.032781392335891724,
0.07087662070989609,
0.07343589514493942,
0.005307170562446117,
0.02466721460223198,
0.05305... |
Management\tAlgorithm:\n\tIron\tDeficiency\tAnemia\n).\nAssessment\nA\tdefinitive\tdiagnosis\tof\tiron\tdeficiency\tanemia\trequires\tmore\tthan\tone\tmethod\tof\tiron\tevaluation;\nserum\tferritin,\tiron,\tand\ttransferrin\tare\tthe\tmost\tuseful.\tThe\tevaluation\talso\tshould\tinclude\tan | [
-0.013185897842049599,
0.018132152035832405,
0.012828396633267403,
-0.007705171592533588,
-0.06883605569601059,
-0.0020903167314827442,
0.128363236784935,
0.03293221816420555,
-0.046237025409936905,
0.02958092838525772,
0.09657100588083267,
-0.03939881920814514,
-0.01064248662441969,
0.042... |
assessment\tof\tcell\tsize\tand\tshape\t(morphology).\tBy\titself,\themoglobin\tconcentration\tis\tunsuitable\tas\na\tdiagnostic\ttool\tin\tcases\tof\tsuspected\tiron\tdeficiency\tanemia\tfor\tthree\treasons:\n\t(1)\tit\tis\taffected\tonly\nlate\tin\tthe\tdisease,\t(2)\tit\tcannot\tdistinguish\tiron\tdeficiency\tfrom\t... | [
0.0030053008813410997,
-0.0645083338022232,
-0.009796755388379097,
-0.015232222154736519,
-0.0752486139535904,
0.0044615366496145725,
0.07982663810253143,
0.042155005037784576,
-0.03462733328342438,
0.09254105389118195,
0.06997759640216827,
-0.04657106474041939,
-0.014221280813217163,
0.08... |
values\tmay\tbe\twithin\tthe\tnormal\trange\tdespite\tiron\tdeficiency.\nAfter\tabsorption,\tiron\tis\ttransported\tby\tplasma\t\ntransferrin\n—a\tbeta-1\tglobulin\t(protein)\tthat\tbinds\niron\tderived\tfrom\tthe\tgastrointestinal\ttract,\tiron\tstorage\tsites,\tor\themoglobin\tbreakdown—to\tthe\nbone\tmarrow | [
-0.011007598601281643,
-0.0756826102733612,
-0.057674795389175415,
-0.04748939350247383,
-0.08953329920768738,
-0.015116543509066105,
0.0758494958281517,
0.09328483045101166,
-0.016382474452257156,
0.03344787284731865,
0.08648370951414108,
0.009849601425230503,
0.019190195947885513,
0.0692... |
bone\tmarrow\n\t(hemoglobin\tsynthesis),\tendothelial\tcells\t(storage),\tor\tplacenta\t(fetal\tneeds). | [
-0.05142210051417351,
-0.04295085370540619,
-0.008481576107442379,
-0.016507074236869812,
-0.059157293289899826,
-0.006601984612643719,
0.04077274352312088,
0.04064379632472992,
-0.035966046154499054,
0.07836927473545074,
0.04055366665124893,
-0.034404002130031586,
-0.04664355516433716,
-0... |
Transferrin\tmolecules\tare\tgenerated\ton\tthe\tsurface\tof\tRBCs\tin\tresponse\tto\tthe\tneed\tfor\tiron.\tWith\niron\tdeficiency,\tso\tmany\t\ntransferrin\treceptors\n\tare\ton\tthe\tcell\tsurface\tunbound\tto\tiron\tthat\tsome\tof\nthem\tbreak\toff\tand\tfloat\tin\tthe\tserum.\tTheir\tpresence\tis\tan\tearly\tsign\... | [
-0.04317750036716461,
-0.07001973688602448,
0.03762858733534813,
-0.05079079419374466,
-0.06765168160200119,
0.00044546142453327775,
0.0655137225985527,
0.007079544011503458,
0.012297490611672401,
0.0367167703807354,
0.08585172146558762,
-0.03507769852876663,
0.020761549472808838,
0.031177... |
higher\tquantity\n\tof\t\nsoluble\tserum\ttransferrin\treceptors\t(STFRs)\n\tmeans\tgreater\tdeficiency\tof\tiron.\nProgressive\tstages\tof\tiron\tdeficiency\tcan\tbe\tevaluated\tby\tmeasurements,\tas\tshown\tin\t\nTable\t31.2\n.\nTABLE\t31.2\nBiochemical\tEvaluation\tof\tIron\tDeficiency\nMeasure\nReference\nRange\nDe... | [
-0.019930405542254448,
-0.09846668690443039,
-0.028133254498243332,
-0.040844645351171494,
-0.10533822327852249,
-0.04703100398182869,
-0.011317910626530647,
0.08343726396560669,
-0.028706390410661697,
0.03802591562271118,
0.03646022081375122,
-0.03159740939736366,
0.020944299176335335,
0.... |
Serum\tor\nplasma\nferritin\nNewborn\t25-200\nng/mL;\t25-\n200\tmcg/dL\nNeonate\t–\t5\nmos\n50-200\nng/mL;\n50-200\nmcg/dL\n6\tmos-15\tyr\n7-142\nng/mL;\t7-\n142\nmcg/dL\nF\t15\tyr\t+\t10-\n150\nng/mL;\n10-150\nmcg/dL\nM\t15\tyr\t+\n12-300\nng/mL;\n12-300\nmcg/dL\nThe\tmost\tsensitive\tindicator\tof\tiron\tdeficiency.\... | [
-0.04747302830219269,
-0.048790570348501205,
-0.019478000700473785,
-0.07911456376314163,
-0.04570693150162697,
0.000734823988750577,
0.03740687668323517,
0.10216473042964935,
-0.06774009019136429,
0.018204743042588234,
0.10357211530208588,
-0.05473167821764946,
0.02613818272948265,
0.0545... |
are\talso\tseen\tin\tsevere\tprotein\tdepletion.\nFemales\t–\t<\t10\tmcg/dL\nMales\t–\t<\t12\tmcg/dL\nSerum\tor\nplasma\tiron\nF\t40-150\nmcg/dL;\t7.2-\n26.9\tmmol/L\nM\t50-160\nmcg/dL;\n8.9-28.7\nmmol/L\nA\tgood\tmeasure\tof\tquantity\tof\tiron\tbound\tto\ttransferrin.\nFemales\t–\t<\t40\tmcg/dL\nMales\t–\t<50\tmcg/dL... | [
-0.04816485568881035,
-0.05155649036169052,
-0.0015021945582702756,
-0.06320147216320038,
-0.13649073243141174,
-0.020046187564730644,
0.0295686237514019,
0.08010905981063843,
-0.03381616622209549,
0.02085454761981964,
0.06351722031831741,
-0.006301832385361195,
0.08725550770759583,
0.0361... |
Total\tiron-\nbinding\ncapacity\n(TIBC)\n250-460\tmcg/dL;\n45-82\tmmol/L\nTIBC\tprimarily\treflects\tliver\tfunction\tand\tis\tan\tindirect\tmeasurement\nof\ttransferrin.\nIncreases\twith\tiron-deficiency\tanemia.\nTransferrin\nsaturation\nF\t15%-50%\nM\t20%-50%\nMeasures\tthe\tiron\tsupply\tto\tthe\ttissues.\nCalculat... | [
-0.01897479221224785,
-0.07225970923900604,
0.011428424157202244,
0.011508860625326633,
-0.08768252283334732,
-0.03218468651175499,
0.06235407665371895,
0.09381067007780075,
-0.047044966369867325,
0.01590150222182274,
0.07540509849786758,
-0.040097810328006744,
0.012314621359109879,
0.0488... |
Calculated\tby\tdividing\tserum\tiron\tby\tthe\tTIBC\tmultiplied\tby\t100.\nLevels\tless\n\tthan\t16%\tare\tconsidered\tinadequate\tfor\terythropoiesis.\nSoluble\tserum\ntransferrin\nreceptor\n(STFR)\nF\t1.9-4.4\tmg/L\nM\t2.2-5\tmg/L\nSTFR\treflects\tthe\trate\tof\tred\tblood\tcell\t(RBC)\tproduction\tin\tbone\nmarrow.... | [
0.005179535131901503,
-0.08979802578687668,
-0.019184544682502747,
-0.0025411893147975206,
-0.055662624537944794,
-0.017417481169104576,
-0.013917289674282074,
0.14410735666751862,
-0.029312269762158394,
0.032692570239305496,
0.06414365023374557,
-0.03292097896337509,
0.003285726998001337,
... |
marrow.\tOrdered\tto\tdifferentiate\tbetween\tiron\tdeficiency\tanemia\nand\tanemia\tof\tchronic\tdisease.\nMore\tsensitive\tthan\tserum\tferritin\tbecause\tit\tis\televated\twith\tiron\ndeficiency,\tis\twithin\tnormal\tlimits\t(WNL)\n\tin\tchronic\tdisease\tor\ninflammation,\tand\tis\tlow\twith\tiron\toverload.\nCreat... | [
-0.03351246193051338,
-0.04148565232753754,
0.021620187908411026,
-0.028229128569364548,
-0.09159248322248459,
0.007011984474956989,
0.07262501865625381,
0.07626587897539139,
-0.03184051066637039,
0.0756111890077591,
0.09436236321926117,
0.003563442500308156,
-0.016639523208141327,
0.04126... |
Protoporphyrin\n\tis\tthe\tiron-containing\tportion\tof\tthe\trespiratory\tpigments\tthat\tcombines\twith\nprotein\tto\tform\themoglobin\tor\tmyoglobin.\tThe\tzinc\tprotoporphyrin\t(ZnPP)/heme\tratio\tis\tmeasured\tto\nassess\tiron\tdeficiency.\tHowever,\tboth\tthis\tZnPP/heme\tratio\tand\themoglobin\n\tlevels\tare\taf... | [
-0.012910058721899986,
-0.0401030071079731,
-0.0069436123594641685,
-0.029338538646697998,
-0.014881225302815437,
0.021283170208334923,
0.06966280192136765,
0.09968400001525879,
-0.009997461922466755,
0.09098807722330093,
0.06544896215200424,
-0.007060410920530558,
-0.05660678818821907,
0.... |
levels\tare\taffected\tby\nchronic\tinfection\tand\tother\tfactors\tthat\tcan\tproduce\ta\tcondition\tthat\tmimics\tiron\tdeficiency\tanemia\nwhen,\tin\tfact,\tiron\tis\tadequate.\nAt\thigher\taltitudes,\twhere\tthere\tis\ta\tlower\tavailability\tof\toxygen,\thematocrit\tand\themoglobin\tlevels\nincrease\tto\tadapt\t(\... | [
-0.008787347003817558,
-0.0689387246966362,
0.03449774906039238,
-0.01692436821758747,
-0.055873338133096695,
0.012672560289502144,
0.07576996833086014,
0.06421323865652084,
-0.07474031299352646,
0.07259896397590637,
0.07505472004413605,
-0.03278867527842522,
0.033340469002723694,
0.078444... |
increase\tto\tadapt\t(\nRyan\tet\tal,\t2014\n).\tThis\tmust\tbe\tconsidered\twhen\tassessing\tanemia.\tHigh\taltitude\nis\t4900\tto\t11,500\tfeet;\tvery\thigh\taltitude\n\tis\t11,500\tto\t18,000\tfeet;\textreme\taltitude\tis\tabove\t18,000\nfeet.\nMedical\tmanagement\nTreatment\tof\tiron\tdeficiency\tanemia\tshould\tfo... | [
0.024327557533979416,
-0.0018310692394152284,
0.020795421674847603,
-0.012022212147712708,
-0.10834771394729614,
-0.027739375829696655,
0.0995824784040451,
0.0812387615442276,
-0.06757698953151703,
0.042331866919994354,
0.048831116408109665,
0.0009560166508890688,
0.028638962656259537,
-0.... |
often\tdifficult\tto\tdetermine.\tThe\tgoal\tis\trepletion\tof\tiron\tstores.\nOral\tsupplementation.\nThe\tchief\ttreatment\tfor\tiron\tdeficiency\tanemia\tinvolves\toral\tadministration\tof\tinorganic\tiron\tin\tthe\nferrous\tform.\n\tAlthough\tthe\tbody\tuses\tferric\tand\tferrous\tiron,\tthe\treduced\tferrous\tis\t... | [
0.04194856062531471,
-0.0897708311676979,
0.033009257167577744,
-0.010849694721400738,
-0.15066710114479065,
0.021938012912869453,
0.07183393836021423,
-0.015200074762105942,
0.038629576563835144,
0.10174453258514404,
0.09226610511541367,
-0.04424304887652397,
0.023468339815735817,
0.03550... |
and\tbetter\tabsorbed.\tAt\ta\tdose\tof\t30\tmg,\tabsorption\tof\tferrous\tiron\tis\tthree\ttimes\tgreater\tthan\tif\tthe | [
0.047917257994413376,
-0.09143775701522827,
-0.011935821734368801,
-0.06254063546657562,
-0.11679734289646149,
-0.004953133407980204,
0.08413717150688171,
0.010516098700463772,
0.009223784320056438,
0.05542230233550072,
0.09980640560388565,
-0.0015036511467769742,
0.043978285044431686,
0.0... |
same\tamount\twere\tgiven\tin\tthe\tferric\tform.\nIron\tis\tbest\tabsorbed\twhen\tthe\tstomach\tis\tempty.\tHowever,\tunder\tthese\tconditions\tit\ttends\tto\ncause\tgastric\tirritation,\twhich\tis\ta\tdirect\tresult\tof\tthe\thigh\tquantity\n\tof\tfree\tferrous\tiron\tin\tthe\nstomach.\tGastrointestinal\tside\teffect... | [
0.040879685431718826,
-0.10836499184370041,
0.042218759655952454,
-0.024225905537605286,
-0.13764849305152893,
-0.04762372747063637,
0.08205725252628326,
-0.0228488240391016,
-0.00922196451574564,
0.04218842834234238,
0.09169761091470718,
0.0009770289761945605,
0.05370638892054558,
0.02926... |
heartburn,\tdiarrhea,\tor\tconstipation.\tIf\tthese\tside\teffects\toccur,\tthe\tpatient\tis\ttold\tto\ttake\tthe\tiron\nwith\tmeals\tinstead\tof\ton\tan\tempty\tstomach;\thowever,\tthis\tsharply\treduces\tthe\tabsorbability\tof\tthe\niron.\tChelated\tforms\tof\tiron\t(combined\twith\tamino\tacids\tor\tKrebs\tcycle\n\t... | [
0.011871595866978168,
-0.0869516059756279,
0.036249469965696335,
-0.010858236812055111,
-0.07998181879520416,
-0.00006499992014141753,
0.10041766613721848,
0.018724529072642326,
-0.0075250910595059395,
0.007152835838496685,
0.08187339454889297,
-0.031200900673866272,
0.051052507013082504,
... |
intermediaries)\tare\tmore\nbioavailable\tthan\tnonchelated\tiron.\tChelated\tiron\tis\tless\taffected\tby\tinhibitors\tof\tiron\tabsorption,\nincluding\tphytate,\toxalate,\tphosphate,\tand\tcalcium.\tChelated\tiron,\tparticularly\tferrous\tbis\tglycinate,\ncauses\tless\tgastrointestinal\tdisturbances\tthan\telemental\... | [
-0.0082083223387599,
-0.08458497375249863,
0.037130288779735565,
-0.0515262745320797,
-0.09565606713294983,
-0.030018867924809456,
0.10881815105676651,
0.02059781923890114,
-0.024025866761803627,
0.06215996667742729,
0.08781725913286209,
-0.021897803992033005,
0.05835747346282005,
0.067500... |
(\nFerrari\tet\tal,\t2012\n;\t\nMilman\tet\tal,\t2013\n).\tMicronutrient\tpowders\t(MNPs)\n\tcontaining\tiron\tmay\tbe\nuseful\tmethods\tof\thome\tfood\tfortification\tfor\tchildren\tunder\tage\t2\t(\nDe-Regil\tet\tal,\t2013\n).\tThe\tMNPs\ncan\tbe\tadded\tto\tsemisolid\tfoods\twithout\taffecting\tthe\tsensory\tappeal\... | [
-0.04694890230894089,
-0.030616674572229385,
0.02633672207593918,
-0.027976814657449722,
-0.06249435618519783,
-0.0005267685046419501,
0.09795212000608444,
-0.005201057996600866,
-0.0018796693766489625,
0.02583914063870907,
0.14523959159851074,
-0.0658051073551178,
0.0629386305809021,
0.02... |
iron\tsupplements\tare\tdiscussed\tin\t\nTable\t31.3\n.\nTABLE\t31.3\nForms\tof\tIron\tSupplements\nIron\tSupplement\nAdvantages\nDisadvantages\nFerrous\tsulfate\nMost\tcommonly\tstudied\nLeast\texpensive\nMost\tconstipating\nFerrous\tgluconate\nGenerally\twell\ttolerated\twith\nfew\tgastrointestinal\tside\neffects\nCa... | [
-0.010333011858165264,
-0.09681373834609985,
0.021206839010119438,
0.08489187806844711,
-0.040568575263023376,
0.026022575795650482,
0.07227471470832825,
0.006405618507415056,
-0.08604540675878525,
0.04939470440149307,
0.025625722482800484,
-0.0000797856118879281,
0.002007139613851905,
0.0... |
effects\nCarbonyl\tiron\t(slow\tiron)\nGenerally\twell\ttolerated\twith\nfew\tgastrointestinal\tside\neffects\nSlow\trate\tof\tsolubilization,\nwhich\tslows\tthe\trate\tof\nabsorption\nChelated\tiron\t(ferrous\tfumarate,\nsuccinate,\taspartate,\tand\tbis\nglycinate)\nBetter\tabsorbed\nFewer\tside\teffects\nLeast\tconst... | [
0.0033302009105682373,
-0.10566768050193787,
0.036983832716941833,
0.02039366401731968,
-0.028588805347681046,
0.02891351282596588,
0.04036927595734596,
0.05746307596564293,
0.005897178780287504,
0.026078607887029648,
0.048669733107089996,
0.03166103735566139,
0.0017378368647769094,
0.0351... |
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