0 stringlengths 12 494 | embeddings listlengths 384 384 |
|---|---|
Fig.\t3.2\n\tin\nChapter\t3\n).\tOverhydration\tis\tcaused\tby\tan\tincrease\tin\tcapillary\thydrostatic\tpressure\tor\tcapillary\npermeability,\tor\ta\tdecrease\tin\tcolloid\tosmotic\tpressure.\tIt\toften\tis\tassociated\twith\trenal\tfailure,\nchronic\theart\tfailure,\tcirrhosis\tof\tthe\tliver,\tCushing’s\tsyndrome,... | [
-0.040447134524583817,
-0.05256952345371246,
0.061208903789520264,
0.007250548340380192,
-0.033797942101955414,
0.008311483077704906,
0.07069023698568344,
0.01879454031586647,
-0.005740464199334383,
0.06097675859928131,
0.07479240745306015,
-0.05504265055060387,
0.022876247763633728,
0.044... |
intravenous\tfluids,\tand\texcessive\tintake\tof\tsodium-containing\tfood\tor\tmedications.\tCharacteristics\ninclude\trapid\tweight\tgain,\tperipheral\tedema,\tdistended\tneck\tveins,\tslow\temptying\tof\tperipheral\nveins,\ta\tbounding\tand\tfull\tpulse,\trales\tin\tthe\tlungs,\tpolyuria,\tascites,\tand\tpleural\teff... | [
0.011451106518507004,
-0.053889043629169464,
0.06057713180780411,
0.030188381671905518,
-0.07311288267374039,
-0.03649984672665596,
0.09787524491548538,
0.03747944161295891,
-0.021388383582234383,
0.030936704948544502,
0.09107501804828644,
-0.047297216951847076,
0.053092874586582184,
0.030... |
edema\tmay\toccur\tin\tsevere\tcases.\nLaboratory\tmeasures\tof\thydration\tstatus\tinclude\tserum\tsodium,\tblood\n\turea\tnitrogen\t(elevated\tout\nof\tproportion\tto\tserum\tcreatinine),\tserum\tosmolality,\tand\turine-specific\tgravity.\tAlthough\tthe\nlaboratory\ttests\tare\timportant,\tdecisions\tregarding\thydra... | [
-0.005862656980752945,
-0.0353565588593483,
0.10096181184053421,
0.003366757184267044,
-0.056944042444229126,
-0.0065222615376114845,
0.06586790084838867,
0.0235772542655468,
-0.013337516225874424,
0.06247744336724281,
0.08258070051670074,
-0.04543454572558403,
0.04184440150856972,
0.01657... |
conjunction\twith\tother\tinformation\tfrom\tphysical\texamination,\tnutrition-focused\tphysical\nexamination,\tand\tthe\tclinical\tcondition\tof\tthe\tpatient.\tIn\taddition,\tmany\tother\tlaboratories\n\tmay\tbe\naffected\tby\toverhydration\tor\tdehydration,\tand\taccurate\tinterpretation\tof\tlaboratory\tresults\tis... | [
0.041438620537519455,
-0.03652922064065933,
0.07090139389038086,
-0.02862737886607647,
-0.11516711860895157,
-0.002011355711147189,
0.060878925025463104,
-0.017814403399825096,
0.0008441212703473866,
0.02406330779194832,
0.08104989677667618,
-0.009247172623872757,
0.03746894747018814,
0.04... |
Inflammation\tand\tbiochemical\tassessment\nInflammation\n\tis\ta\tprotective\tresponse\tby\tthe\timmune\tsystem\tto\tinfection,\tacute\tillness,\ttrauma,\ntoxins,\tmany\tchronic\tdiseases,\tand\tphysical\tstress.\tBiochemical\tindices\tare\taffected\tby\tinflammation\nprimarily\n\tby\tredirection\tto\tsynthesis\tof\ta... | [
0.012776287272572517,
-0.11334094405174255,
0.03722049668431282,
-0.015871385112404823,
-0.0897805318236351,
0.06687409430742264,
0.09291597455739975,
0.09420620650053024,
-0.007236011326313019,
0.11897055804729462,
0.025901904329657555,
-0.03728152811527252,
0.037545688450336456,
0.074930... |
immune\tresponse\tto\trelease\teicosanoids\tand\tcytokines,\twhich\tmobilize\tnutrients\trequired\tto\nsynthesize\t\npositive\tacute-phase\treactants\n\t(which\tincrease\tin\tresponse\tto\tinflammation)\tand\nleukocytes.\tCytokines\t(interleukin-1beta\t[IL-1β],\ttumor\tnecrosis\tfactor\talpha\t[TNF-α],\tinterleukin-6\n... | [
-0.03535452485084534,
-0.034969743341207504,
0.007402455434203148,
-0.017678221687674522,
-0.06052420660853386,
0.06792843341827393,
0.06451087445020676,
0.10327575355768204,
-0.0045672147534787655,
0.07901634275913239,
0.023344706743955612,
-0.018491895869374275,
0.01982302963733673,
0.01... |
[IL-6]),\tand\teicosanoids\n\t(prostaglandin\tE2\t[PGE2])\tinfluence\twhole-body\tmetabolism,\tbody\ncomposition,\tand\tnutritional\tstatus.\tCytokines\treorient\thepatic\tsynthesis\tof\tplasma\tproteins\tand\nincrease\tthe\tbreakdown\tof\tmuscle\tprotein\tto\tmeet\tthe\tdemand\tfor\tprotein\tand\tenergy\tduring\tthe | [
-0.014560947194695473,
-0.057756416499614716,
0.024751899763941765,
-0.031044358387589455,
-0.06569012999534607,
0.009904933162033558,
0.08133376389741898,
0.09480123221874237,
-0.013396205380558968,
0.07262120395898819,
0.06590427458286285,
0.01612059958279133,
-0.04896590858697891,
0.022... |
inflammatory\tresponse.\tMoreover,\tthere\tis\ta\tredistribution\tof\talbumin\tto\tthe\tinterstitial\ncompartment,\tresulting\tin\tedema.\tDeclining\tvalues\tof\n\tthe\t\nnegative\tacute-phase\treactants\n\t(i.e.,\nserum\talbumin,\tprealbumin,\tand\ttransferrin)\talso\treflect\tthe\tinflammatory\tprocesses\tand\tseveri... | [
0.03451834246516228,
-0.11433422565460205,
0.033404186367988586,
-0.011901089921593666,
-0.10212250053882599,
0.02846844680607319,
0.0720820501446724,
0.0517442561686039,
0.02854027971625328,
0.07655199617147446,
0.07098384201526642,
0.019087698310613632,
0.027226736769080162,
0.0790348947... |
tissue\tinjury.\tIn\tthe\tacute\tinflammatory\tstate,\tnegative\tacute\tphase\treactant\tvalues\tdo\tnot\treflect\ncurrent\tdietary\tintake\tor\tprotein\tstatus\t(\nWhite\tet\tal,\t2012\n).\nCytokines\timpair\tthe\tproduction\tof\terythrocytes\tand\treorient\tiron\tstores\tfrom\themoglobin\tand | [
-0.011890973895788193,
-0.07647163420915604,
0.021634899079799652,
-0.06635965406894684,
-0.10216335207223892,
0.04287039861083031,
0.10885652154684067,
0.0755540132522583,
-0.031678736209869385,
0.13815250992774963,
0.07466452568769455,
-0.025206075981259346,
-0.02076716534793377,
0.09268... |
serum\tiron\tto\tferritin.\tDuring\tinfection\tIL-1β\tinhibits\tthe\tproduction\tand\trelease\tof\ttransferrin\twhile\nstimulating\tthe\tsynthesis\tof\tferritin.\tTherefore\tlaboratory\ttest\tresults\tused\tto\tpredict\tthe\trisk\tof\nnutritional\tanemias\t(see\t\nChapter\t31\n)\tare\tnot\tuseful\tin\tassessing\tthe\tp... | [
-0.0016430554678663611,
-0.04393422603607178,
0.030673135071992874,
-0.0025167677085846663,
-0.08193694800138474,
0.019912535324692726,
0.10032226890325546,
0.07255847752094269,
-0.047426868230104446,
0.012692449614405632,
0.07275176048278809,
-0.035741861909627914,
0.0009783514542505145,
... |
response.\tRefer\tto\t\nChapter\t7\n\tfor\tmore\tinformation\ton\tthe\teffects\tof\tcytokines\ton\torgan\tsystems.\nAs\tthe\tbody\tresponds\tto\tacute\tinflammation,\tTNF-α,\tIL-1β,\tIL-6,\tand\tPGE2\tincrease\tto\ta\tset\nthreshold,\tthen\tIL-6\tand\tPGE2\tinhibit\tTNF-α\tsynthesis\tand\tIL-1β\tsecretion,\tcreating\ta... | [
-0.07207942754030228,
-0.0788256973028183,
0.006526765413582325,
-0.040944866836071014,
-0.06231564283370972,
0.02117694914340973,
0.06446710228919983,
0.06089921295642853,
-0.0004994866321794689,
0.05065656080842018,
0.07220986485481262,
-0.05948884040117264,
-0.04307486489415169,
0.02910... |
feedback\tcycle.\tHepatic\tsynthesis\tof\tpositive\tacute-phase\treactants\tdiminishes,\tand\tsynthesis\tof\nnegative\tacute-phase\treactants\tincreases.\tAlbumin\tshifts\tfrom\tthe\tinterstitial\tcompartment\tto\tthe\nextravascular\tspace\n\twhere\tit\tcan\tbe\tmeasured\tas\tserum\talbumin.\tAlbumin\tin\tthe\tintersti... | [
-0.03467706963419914,
-0.058698080480098724,
0.014225328341126442,
-0.0193661879748106,
-0.08307493478059769,
0.03232941776514053,
0.06133226305246353,
0.034105800092220306,
-0.00421828031539917,
0.06671670824289322,
0.06942274421453476,
-0.06778611242771149,
0.03900176286697388,
-0.002200... |
cannot\tbe\tmeasured,\ttherefore\talbumin\tis\tnot\ta\treliable\tmarker\tfor\tprotein\tstatus.\tIron\tstores\tshift\nfrom\tferritin\tto\ttransferrin\tand\themoglobin.\nMarkers\tof\tinflammation\nBiochemical\tmarkers\tof\tinflammation\tinclude\tpositive\tacute\tphase\treactants\tand\tnegative\tacute\nphase\treactants.\t... | [
0.01796526461839676,
-0.10626919567584991,
0.011873519979417324,
-0.04885590076446533,
-0.08872675150632858,
0.03383095562458038,
0.07950606942176819,
0.05687771737575531,
-0.014333036728203297,
0.09374263137578964,
0.08845442533493042,
-0.036979109048843384,
0.02300657331943512,
0.0884016... |
phase\treactants.\tIn\tthe\tpresence\tof\tinflammation,\tthe\n\thepatic\tsynthesis\tof\tpositive\tacute-phase\nreactants\tis\t\nincreased\n\twhile\tthe\tsynthesis\tof\tthe\tnegative\tacute-phase\treactants\tis\t\ndepressed.\n\tSee\nTable\t5.4\n\tfor\tacute\tphase\treactants.\tAdditional\tmarkers\tof\toxidative\tstress\... | [
0.0022225510329008102,
-0.09026060998439789,
0.036666519939899445,
-0.027010802179574966,
-0.09304678440093994,
0.07317601144313812,
0.03052898868918419,
0.042258597910404205,
-0.03535394370555878,
0.11189673840999603,
0.08327638357877731,
-0.03288711979985237,
0.0076956297270953655,
0.050... |
found\tin\t\nTable\t5.5\n.\nTABLE\t5.4\nAcute\tPhase\tReactants\nPositive\tAcute-Phase\tReactants\nNegative\tAcute-Phase\tProteins\nC-reactive\tprotein\nAlbumin\na\n-\n1\n\tantichymotrypsin\nTransferrin\na\n1\n-antitrypsin\nPrealbumin\t(transthyretin)\nHaptoglobins\nRetinol-binding\tprotein\nCeruloplasmin\nSerum\tamylo... | [
-0.030910708010196686,
-0.0762581080198288,
0.010670549236238003,
0.0006008303025737405,
-0.02674379013478756,
0.0734788104891777,
0.030416399240493774,
0.1057693138718605,
-0.001002695644274354,
0.1087876409292221,
0.07126343995332718,
-0.035100050270557404,
-0.0020644241012632847,
0.1087... |
Fibrinogen\nFerritin\nComplement\tand\tcomponents\tC3\tand\tC4\nOrosomucoid\nTABLE\t5.5\nAdvantages\tand\tDisadvantages\tof\tVarious\tBiomarkers\tof\tOxidative\tStress\nBiomarker\nAdvantages\nDisadvantages\nComments\nIsoPs\t(isoprostanes)\nCan\tbe\tdetected\tin\tvarious\tsamples\n(serum,\turine)\tand\thas\tbeen\nshown\... | [
0.011597462929785252,
-0.08594252169132233,
0.060965489596128464,
-0.007043072488158941,
-0.05183420330286026,
0.058398421853780746,
0.10959671437740326,
0.049950819462537766,
-0.04948563873767853,
0.08226212859153748,
0.08590928465127945,
-0.0772579163312912,
-0.012011390179395676,
0.0838... |
shown\tto\tbe\televated\tin\tthe\npresence\tof\ta\trange\tof\tCV\trisk\nfactors\nCurrent\tmethods\tof\nquantification\tare\nimpractical\tfor\nlarge-scale\nscreening.\nNo\tevidence\nlinking\tthis\nbiomarker\tto\nclinical\noutcomes\tyet.\nF\n2\n-IsoPs\tshow\nmost\tpotential\nMDA\t(mal-\nondialdehyde)\nTechnically\teasy\t... | [
-0.012196427211165428,
-0.07955127209424973,
0.03356492146849632,
-0.027133870869874954,
-0.0521622970700264,
-0.0006871671066619456,
0.03346957638859749,
0.05226916819810867,
0.0008819663198664784,
0.03817446157336235,
0.13834038376808167,
-0.049272920936346054,
0.003209718270227313,
0.06... |
spectrophotometrically\tusing\nthe\tTBARS\tassay\tELISA\tkits\tto\ndetect\tMDA\talso\thave\tgood\nperformance\nStudies\tshow\tMDA\tcan\tpredict\nTBARS\tassay\tis\nnonspecific\t(can\ndetect\taldehydes\nother\tthan\tMDA)\nand\tsample\npreparation\tcan\nShows\tpromise\tas\na\tclinical\nbiomarker;\nhowever,\tdoes\nnot\thav... | [
0.009156313724815845,
-0.0814092755317688,
0.03800949454307556,
-0.045720312744379044,
-0.060124993324279785,
-0.0008904026472009718,
0.07178551703691483,
0.034105926752090454,
-0.006388732697814703,
0.07564032077789307,
0.14329388737678528,
-0.05032621696591377,
0.023942630738019943,
0.03... |
progression\tof\tCAD\tand\tcarotid\natherosclerosis\tat\t3\tyears\ninfluence\tresults.\nimpact\ton\tthe\npathophysiology\nof\tCVD\nNitrotyrosine\t(3-\nNO2-tyr)\nHuman\tstudies\thave\tdemonstrated\nassociation\twith\tCAD\nindependent\tof\ttraditional\trisk\nfactors\nCirculating\tlevels\nare\tnot\nequivalent\tto\ntissue\... | [
0.0022362989839166403,
-0.09614746272563934,
0.028550224378705025,
-0.03304262086749077,
-0.1399509161710739,
0.01669583097100258,
0.03192577138543129,
0.043344371020793915,
-0.005271841771900654,
0.08288168162107468,
0.0899517834186554,
-0.02788661979138851,
-0.0007100224611349404,
0.0619... |
Current\tdetection\nmethods\tare\nexpensive\tand\nimpractical.\nNitrotyrosine\nformation\ton\nparticular\ncardiovascular\nproteins\thas\ndirect\teffect\ton\nfunction\nS-glutathionylation\nS-glutathionylation\n\tof\tSERCA,\neNOS\tand\tNa\n+\n–K\n+\n\tpump\ndemonstrated\tas\tbiomarkers\tas\nwell\tas\trole\tin\tpathogenes... | [
-0.003414436476305127,
-0.10339158028364182,
0.015876447781920433,
0.0026612202636897564,
-0.08547106385231018,
0.021135251969099045,
0.07186172902584076,
0.06932970881462097,
-0.02462964504957199,
0.09597272425889969,
0.12014076858758926,
-0.040127068758010864,
0.0006380971171893179,
0.07... |
Detection\tof\tS-\nglutathionylation\nprone\tto\nmethodological\nartifact\nAccess\tto\ttissue\n(myocardium,\nvasculature),\nwhere\nmodification\noccurs\tpresents\ta\nclinical\tobstacle\nModified\nhemoglobin\ncurrently\tbeing\ninvestigated\tas\nbiomarker\nMyeloperoxidase\n(MPO)\nCommercial\tassays\tavailable.\tAn\nenzym... | [
-0.004959280602633953,
-0.06864552199840546,
-0.004882763605564833,
-0.00763984490185976,
-0.05633774772286415,
0.015231765806674957,
0.06998126208782196,
0.02306876704096794,
-0.03620545193552971,
0.09402252733707428,
0.11183235794305801,
-0.037464600056409836,
0.0004405891231726855,
0.08... |
enzyme\tabundant\tin\n\tgranules\tin\ninflammatory\tcells.\tStrong\nevidence\tthat\tMPO\tcorrelates\nwith\tCVD\trisk\nInfluenced\tby\nsample\tstorage\nand\ttime\tto\nanalysis\nMPO\tis\ta\npromising\nbiomarker\tfor\nCVD\trisk\nprediction\nOxidized\tLDL\ncholesterol\n(OxLDL)\nForms\tand\toccurs\tin\tvascular\twalls\nas\t... | [
-0.03262193500995636,
-0.11808828264474869,
-0.014111418277025223,
-0.04420434311032295,
-0.06863554567098618,
0.008050852455198765,
0.005871253553777933,
0.08036871254444122,
-0.01020535547286272,
0.06477116793394089,
0.09594385325908661,
-0.029901908710598946,
0.006716315634548664,
0.072... |
as\tfoam\tcells\tand\tstimulates\nproduction\tof\tproinflammatory\ncytokines\tby\tendothelial\tcells.\nElevated\tin\tCAD,\tincreasing\nOxLDL\tcorrelates\twith\nincreasing\tclinical\tseverity.\tAlso\nis\tpredictive\tof\tfuture\tCAD\tin\nhealthy\tpopulation.\tGood\nreproducibility\tfrom\tfrozen\nsamples\nReduction\tin\tO... | [
-0.011365506798028946,
-0.11712906509637833,
0.020742999389767647,
-0.027302373200654984,
-0.08722516894340515,
0.02379653789103031,
0.06527933478355408,
0.04523950442671776,
-0.02708366885781288,
0.06440897285938263,
0.0966666042804718,
-0.030777093023061752,
0.02332712709903717,
0.076955... |
by\tantioxidant\npharmacotherapy\nhas\tnot\tbeen\nmatched\tby\nreduction\tin\tCVD\nseverity.\nELISAs\tfor\tOxLDL\ndetection\nreadily\tavailable\nROS-induced\nchanges\tto\tgene\nexpression\nThe\texpression\tof\tseveral\tgenes\ninvolved\tin\tregulating\toxidative\nstress\tmay\tbe\n\tmeasured\nsimultaneously\tusing\tmicro... | [
-0.016794713214039803,
-0.062232375144958496,
0.023095283657312393,
0.021738020703196526,
-0.03038189373910427,
0.02507891319692135,
0.09528116881847382,
0.02340680919587612,
-0.03254394605755806,
0.06278162449598312,
0.10225045680999756,
0.013616673648357391,
0.048247285187244415,
0.03145... |
technology,\tpotentially\nincreasing\tthe\tpower\tof\tthis\nbiomarker\nMicroarray\ntechnology\tcan\nbe\tmanually\tand\ncomputationally\nexpensive\nIt\tis\tunclear\tif\nexpression\nprofiles\tof\tcells\nin\tbiologic\nsamples\treflect\nthat\tin\ncardiovascular\ntissues\nSerum\tantioxidant\ncapacity\nActivity\tof\tantioxid... | [
-0.005796593148261309,
-0.09371025860309601,
0.010950629599392414,
0.018576500937342644,
-0.04610026627779007,
0.03314483165740967,
0.07405686378479004,
0.057301115244627,
-0.04945458471775055,
0.09264378249645233,
0.07575077563524246,
-0.035478487610816956,
-0.014915267005562782,
0.041740... |
Activity\tof\tantioxidant\tenzymes\nsuch\tas\tglutathione\tperoxidase\t1\n(GPX-1)\tand\tsuperoxide\ndismutase\t(SOD)\tare\ndemonstrated\tto\tbe\tinversely\nproportional\tto\tCAD.\nCommercial\tkits\tavailable\tto\nmeasure\tantioxidant\tcapacity.\nReproducibly\tquantified\tdespite\nfrozen\tsample\tstorage\nAntioxidant\ta... | [
0.0029637152329087257,
-0.10163542628288269,
0.02910308539867401,
0.010611436329782009,
-0.01055974792689085,
0.03970777243375778,
0.06143182888627052,
0.018665190786123276,
-0.018703587353229523,
0.061032459139823914,
0.08691868931055069,
-0.012473058886826038,
-0.014039703644812107,
0.04... |
in\tserum\tmay\tnot\nreflect\tthat\tof\tthe\ncells\tthat\tare\nimportant\tto\tthe\npathogenesis\tof\nCVD\nClinical\trelevance\nof\tantioxidant\nquantification\tto\nCVD\trisk\tneeds\nfurther\ninvestigation\nCAD\n,\tCoronary\n\tartery\tdisease;\t\nCV\n,\tcardiovascular;\t\nCVD\n,\tcardiovascular\tdisease;\t\nELISA\n,\ten... | [
0.008556382730603218,
-0.09434253722429276,
0.006318267900496721,
-0.06386420875787735,
-0.09295827895402908,
0.011100031435489655,
0.020637473091483116,
0.048876289278268814,
-0.02632737159729004,
0.09166464954614639,
0.09578171372413635,
-0.04072245955467224,
0.0016544840764254332,
0.042... |
ELISA\n,\tenzyme-linked\timmunosorbent\tassay;\t\nTBARS\n,\nthiobarbituric\tacid\t(TBA)\treacting\tsubstances;\t\neNOS\n,\tendothelial\tnitric\toxide\tsynthase;\t\nGPX-1\n,\tglutathione\tperoxidase-1,\t\nROS\n,\treactive\toxygen\nspecies;\t\nSERCA\n,\tsarcoplasmic\treticulum\tCa\n2+\n\t-ATPase,\t\nSOD\n,\tsuperoxide\td... | [
-0.03740811347961426,
-0.059459138661623,
0.002969699678942561,
-0.048143867403268814,
-0.05318343639373779,
0.00936831347644329,
0.02079831436276436,
0.09545359760522842,
-0.027652794495224953,
0.07606472074985504,
0.022072916850447655,
-0.026426006108522415,
0.006285029463469982,
0.11028... |
,\tsarcoplasmic\treticulum\tCa\n2+\n\t-ATPase,\t\nSOD\n,\tsuperoxide\tdismutase.\nAdapted\tfrom\tHo\tE\tet\tal:\tBiological\tmarkers\tof\toxidative\tstress:\n\tapplications\tto\tcardiovascular\tresearch\tand\tpractice,\t\nRedox\tBiology\n\t1:483,\t2013.\nPositive\tacute\tphase\treactants\nC-reactive\tprotein\nC-reactiv... | [
-0.020909829065203667,
-0.08468910306692123,
0.030235789716243744,
-0.024754341691732407,
-0.05158005654811859,
0.059874940663576126,
0.011905957013368607,
0.1235077753663063,
-0.008335227146744728,
0.09718986600637436,
0.026568813249468803,
-0.02886381931602955,
0.013696825131773949,
0.09... |
C-reactive\tprotein\nC-reactive\tprotein\t(CRP)\n\tis\ta\tnonspecific\tmarker\tof\tinflammation\tthat\tmay\thelp\testimate\tand\nmonitor\tthe\tseverity\tof\tillness.\t\nHigh-sensitivity\tCRP\t(hs-CRP)\n\tis\ta\tmore\tsensitive\tmeasure\tof\nchronic\tinflammation\tseen\tin\tpatients\twith\tatherosclerosis\tand\tother\tc... | [
-0.02870473451912403,
-0.08687731623649597,
0.03853236511349678,
0.011341468431055546,
-0.05895226076245308,
0.045177578926086426,
0.04623202979564667,
0.14811080694198608,
-0.002152866916731,
0.053842365741729736,
0.06605618447065353,
-0.0260589849203825,
0.061306193470954895,
0.105812542... |
diseases\t(\nWang\tet\tal,\n2017\n).\tAlthough\tthe\texact\tfunction\tof\tCRP\tis\tunclear,\tit\tincreases\tin\tthe\tinitial\tstages\tof\tacute\tstress\n—usually\twithin\t4\tto\t6\thours\tof\tsurgery\tor\tother\ttrauma.\tFurthermore,\tits\tlevel\tcan\tincrease\tas\tmuch\nas\t1000-fold,\tdepending\ton\tthe\tintensity\to... | [
-0.007289439905434847,
-0.046068884432315826,
0.04500944912433624,
-0.05299725756049156,
-0.11946884542703629,
-0.011426538228988647,
0.08079880475997925,
0.05174233764410019,
-0.008731820620596409,
0.06476254016160965,
0.10801301151514053,
-0.01756053790450096,
0.06879167258739471,
0.0455... |
decrease,\tthe\tpatient\thas\tentered\tthe\tanabolic\tperiod\tof\tthe\tinflammatory\tresponse\n\tand\tthe\nbeginning\tof\trecovery\twhen\tmore\tintensive\tnutrition\ttherapy\tmay\tbe\tbeneficial.\tOngoing\tassessment\nand\tfollow-up\tare\trequired\tto\taddress\tchanges\tin\tnutrition\tstatus. | [
0.06571461260318756,
0.012009434401988983,
0.07235585153102875,
-0.0009258343488909304,
-0.1117284819483757,
0.021312298253178596,
0.10305220633745193,
0.04472152888774872,
0.016192005947232246,
0.016742326319217682,
0.08846431970596313,
0.006796593312174082,
0.03010966256260872,
0.0459779... |
Ferritin\nFerritin\n\tis\ta\tpositive\tacute-phase\tprotein,\tmeaning\tthat\tsynthesis\tof\tferritin\tincreases\tin\tthe\npresence\tof\tinflammation.\tFerritin\tis\tnot\ta\treliable\tindicator\tof\tiron\tstores\tin\tpatients\twith\tacute\ninflammation,\n\turemia,\tmetastatic\tcancer,\tor\talcoholic-related\tliver\tdise... | [
0.013342354446649551,
-0.10392044484615326,
0.017296405509114265,
0.0071318866685032845,
-0.11741342395544052,
0.04867977648973465,
0.09973639249801636,
0.05758994445204735,
-0.017601121217012405,
0.043516725301742554,
0.058908186852931976,
-0.0033727127593010664,
-0.00814172811806202,
0.0... |
inflammatory\tmediators\tcan\tincrease\tferritin\tsynthesis,\tferritin\tleakage\tfrom\tcells,\tor\tboth.\nElevations\tin\tferritin\toccur\t1\tto\t2\tdays\tafter\tthe\tonset\tof\tthe\tacute\tillness\tand\tpeak\tat\t3\tto\t5\tdays.\tIf\niron\tdeficiency\talso\texists,\tit\tmay\tnot\tbe\tdiagnosed\tbecause\tthe\tlevel\tof... | [
0.011930414475500584,
-0.08126633614301682,
0.04079347848892212,
-0.024161117151379585,
-0.1168377548456192,
0.008981694467365742,
0.059510309249162674,
0.00815482810139656,
-0.006346351932734251,
0.07610659301280975,
0.08027908205986023,
0.0021029331255704165,
0.04562173783779144,
0.04948... |
elevated.\nErythrocyte\tsedimentation\trate\nErythrocyte\tsedimentation\trate\t(ESR)\n\treflects\tthe\trate\tat\twhich\tRBCs\tsettle\tinto\tcolumns\tor\nstacks\tin\ta\tsaline\tor\tplasma\twithin\ta\tgiven\ttime\tperiod.\tInflammatory\tprocesses\tlead\tto\tincreased\nweight\tof\tthe\tRBC\tand\tmore\tlikely\tto\tsettle\t... | [
-0.014136831276118755,
-0.07549144327640533,
0.032670773565769196,
-0.026863250881433487,
-0.1427847445011139,
-0.023488856852054596,
0.08537278324365616,
0.06370861083269119,
-0.03181201219558716,
0.04468467831611633,
0.06927169859409332,
-0.023768369108438492,
0.009907878004014492,
0.066... |
differentiating\tdisease\tentities\tand\tis\talso\tused\tto\tmonitor\tdisease\ttherapy\t(i.e.,\n\tas\tESR\tincreases,\nthe\tdisease\tstate\tworsens)\t(\nLitchford,\t2017\n).\nNegative\tacute\tphase\treactants\nAlbumin\nAlbumin\n\tis\tresponsible\tfor\tthe\ttransport\tof\tmajor\tblood\tconstituents,\thormones,\tenzymes, | [
0.0717179924249649,
-0.029791412875056267,
0.05156335234642029,
-0.06222941726446152,
-0.09167176485061646,
0.04394088685512543,
0.07905623316764832,
0.016182739287614822,
-0.01329690869897604,
0.10038920491933823,
0.09518684446811676,
-0.07906980812549591,
0.015033308416604996,
0.09535036... |
medications,\tminerals,\tions,\tfatty\tacids,\tamino\tacids,\tand\tmetabolites.\tA\tmajor\trole\tof\talbumin\tis\tto\nmaintain\tcolloidal\tosmotic\tpressure,\tproviding\tapproximately\t80%\tof\tcolloidal\tosmotic\tpressure\n\tof\nthe\tplasma.\tWhen\tserum\talbumin\tlevels\tdecrease,\tthe\twater\tin\tthe\tplasma\tmoves\... | [
-0.021169045940041542,
-0.08367129415273666,
0.019599050283432007,
-0.018044598400592804,
-0.08279135823249817,
-0.008927826769649982,
0.08214455842971802,
0.10655184835195541,
0.001377259730361402,
0.021611841395497322,
0.0420675091445446,
0.003026639111340046,
0.08035185933113098,
0.0711... |
compartment\tand\tedema\tresults.\tThis\tloss\tof\tplasma\tfluid\tresults\tin\thypovolemia,\twhich\ttriggers\nrenal\tretention\tof\twater\tand\tsodium.\nAlbumin\thas\ta\thalf-life\tof\t18\tto\t21\tdays.\tLevels\tof\talbumin\tremain\tnearly\tnormal\tduring\nuncomplicated\tstarvation\tas\tredistribution\tfrom\tthe\tinter... | [
-0.018690716475248337,
-0.04984621703624725,
0.03655480593442917,
-0.01870882138609886,
-0.0481443777680397,
-0.03284228593111038,
0.07014819234609604,
0.019205009564757347,
0.003383590606972575,
0.044145938009023666,
0.09890798479318619,
-0.031403299421072006,
0.03619995340704918,
0.04568... |
plasma\toccurs.\tLevels\tof\nalbumin\tfall\tprecipitously\tin\tinflammatory\tstress\tand\toften\tdo\tnot\timprove\twith\taggressive\tnutrition\nsupport.\tSerum\tlevels\treflect\tthe\tseverity\tof\tillness\tbut\tdo\tnot\treflect\tcurrent\tprotein\tstatus\tor\tthe\neffects\tof\tnutrient-dense\tsupplemental\tnutrition.\tF... | [
0.0053080106154084206,
-0.100972980260849,
0.054881881922483444,
0.0023776341695338488,
-0.0655767023563385,
0.036285534501075745,
0.08348233252763748,
0.0467986986041069,
-0.0028755050152540207,
0.04360170662403107,
0.07307080179452896,
-0.05138872563838959,
0.045039981603622437,
0.049061... |
patient\tmay\thave\tlow\tlevels\tof\talbumin\tand\tthe\thepatic\ttransport\tproteins,\n\twhereas\ta\tpatient\twho\nhas\thad\tsignificant\tweight\tloss\tand\tundernutrition\tmay\thave\tnormal\tor\tclose\tto\tnormal\tlevels.\nAlbumin\tis\tvery\tsensitive\tto\thydration\tstatus,\tand\tthe\tpractitioner\tmust\tbe\taware\ta... | [
0.014683250337839127,
-0.010537647642195225,
0.03751927241683006,
0.004043017979711294,
-0.06753833591938019,
0.013469155877828598,
0.06969399005174637,
0.03911769390106201,
-0.012450817972421646,
0.012657726183533669,
0.12036533653736115,
0.011010066606104374,
0.06329721212387085,
0.03829... |
true\tcause\tof\tan\televated\tor\tdepressed\talbumin\tlevel.\nAlbumin\tis\tsynthesized\tin\tthe\tliver\tand\tis\ta\tmeasure\tof\tliver\tfunction.\tWhen\tdisease\taffects\tthe\nliver,\tthe\tsynthesis\tof\talbumin,\n\tby\tthe\thepatocytes,\tis\timpaired.\tBecause\tof\tthe\thalf-life\tof\talbumin,\nsignificant\tchanges\t... | [
-0.05086998641490936,
-0.08608710020780563,
0.042472582310438156,
-0.00956259947270155,
-0.06395669281482697,
0.026090310886502266,
0.0640498548746109,
0.027248810976743698,
-0.006890712305903435,
0.10706061124801636,
0.10260020941495895,
-0.033188596367836,
0.0172054972499609,
0.047106008... |
Prealbumin\t(transthyretin)\nPrealbumin\t(PAB)\n,\tofficially\t\ntransthyretin\t(TTHY)\n,\tis\ta\thepatic\tprotein\ttransported\tin\tthe\tserum\nas\ta\tcomplex\tof\tretinol-binding\tprotein\tand\tvitamin\tA.\tIt\ttransports\tthe\tthyroid\thormones\ntriiodothyronine\tand\tthyroxine\t(T\n4\n),\talong\n\twith\tT\n4\n-bind... | [
-0.04038127139210701,
-0.10570714622735977,
0.0015010240022093058,
-0.04653206467628479,
-0.07973933219909668,
0.026371043175458908,
0.03288540616631508,
0.11645365506410599,
-0.019868062809109688,
0.04544606804847717,
0.07381374388933182,
-0.002502479823306203,
-0.005657660774886608,
0.06... |
with\tT\n4\n-binding\tglobulin.\tIt\thas\ta\tshort\thalf-life\t(t½\t=\t2\ndays),\tand\tcurrently\tit\tis\tconsidered\ta\tmarker\tof\tinflammation.\tLevels\tof\tPAB\tplummet\tin\ninflammatory\tstress\tand\tare\tnot\tsensitive\tmeasures\tto\tevaluate\tthe\teffectiveness\tof\taggressive\nnutrition\tsupport.\tMoreover,\tse... | [
0.01719028688967228,
-0.045611828565597534,
0.009705469012260437,
-0.001966736512258649,
-0.0657317042350769,
0.025909649208188057,
0.08825971186161041,
0.06305120140314102,
0.021852118894457817,
0.03931981697678566,
0.07638750225305557,
-0.030985964462161064,
0.04534774273633957,
0.053274... |
the\tintestines\tor\tkidneys.\tSerum\tlevels\tdo\tnot\treflect\n\tprotein\tstatus\tor\tthe\teffects\tof\trefeeding\tin\tthe\nindividual\twith\tdepleted\tprotein\treserves.\tSerum\tlevels\talso\tdecrease\tin\tthe\tpresence\tof\ta\tzinc\ndeficiency\tbecause\tzinc\tis\trequired\tfor\thepatic\tsynthesis\tand\tsecretion\tof... | [
-0.019338352605700493,
-0.09025539457798004,
0.01707194373011589,
-0.017579959705471992,
-0.08333071321249008,
0.028238076716661453,
0.05188940092921257,
0.034202851355075836,
-0.022291535511612892,
0.10413938760757446,
0.11437077820301056,
-0.027674585580825806,
0.024849997833371162,
0.03... |
from\tdietary\tintake\tand\tmedical\thistory,\tin\taddition\tto\tinflammation,\twhen\tinterpreting\tlow\tplasma\nPAB\tlevels.\nPAB\tlevels\tare\toften\tnormal\tin\tstarvation-related\n\tmalnutrition\tbut\tdecreased\tin\twell-nourished\nindividuals\twho\thave\tundergone\trecent\tstress\tor\ttrauma.\tDuring\tpregnancy,\t... | [
0.002714528003707528,
0.004003305919468403,
0.026306618005037308,
0.010667848400771618,
-0.0731186792254448,
0.032139379531145096,
0.05633304640650749,
0.040131114423274994,
-0.060396142303943634,
0.04966961592435837,
0.09091413766145706,
-0.03653787449002266,
0.023414745926856995,
-0.0353... |
levels\tstimulate\tPAB\tsynthesis\tand\tserum\tlevels\tmay\tincrease.\tIn\tnephrotic\tsyndrome,\tPAB\tlevels\nalso\tmay\tbe\tincreased.\tProteinuria\tand\thypoproteinemia\tare\tcommon\tin\tnephrotic\tsyndrome,\tand\nbecause\tPAB\tis\tsynthesized\trapidly,\ta\tdisproportionate\tpercentage\n\tof\tPAB\tcan\texist\tin\tthe... | [
-0.016522999852895737,
-0.041911184787750244,
0.032482121139764786,
-0.017097529023885727,
-0.04382685571908951,
0.01991649717092514,
0.036537736654281616,
0.05537489801645279,
-0.03851276636123657,
0.04420978203415871,
0.10228751599788666,
-0.016677087172865868,
0.05151072517037392,
0.023... |
whereas\tother\tproteins\ttake\tlonger\tto\tproduce\t(\nLitchford,\t2017\n).\nRetinol-binding\tprotein\nThe\thepatic\tprotein\twith\tthe\tshortest\thalf-life\t(t\t½\t=\t12\thr)\tis\t\nretinol-binding\tprotein\t(RBP)\n,\ta\nsmall\tplasma\tprotein\tthat\tdoes\tnot\tpass\tthrough\tthe\trenal\tglomerulus\tbecause\tit\tcirc... | [
-0.01503072027117014,
-0.08584896475076675,
0.011265420354902744,
-0.0484720841050148,
-0.08680736273527145,
-0.019001802429556847,
0.021218368783593178,
0.07308479398488998,
0.044921066612005234,
0.040945716202259064,
0.07781793177127838,
0.04381817951798439,
0.04565780237317085,
0.080220... |
complex\twith\tPAB.\tAs\timplied\tby\tits\tname,\tRBP\tbinds\t\nretinol\n,\tand\ttransport\tof\n\tthis\tvitamin\tA\nmetabolite\tseems\tto\tbe\tits\texclusive\tfunction.\tRBP\tis\tsynthesized\tin\tthe\tliver\tand\treleased\twith\nretinol.\tAfter\tRBP\treleases\tretinol\tin\tperipheral\ttissue,\tits\taffinity\tfor\tPAB\t... | [
0.017816675826907158,
-0.06746366620063782,
0.046869173645973206,
-0.04312557727098465,
-0.0821346789598465,
-0.020321179181337357,
0.10358259826898575,
-0.012362590059638023,
-0.020845899358391762,
0.06045949459075928,
0.0874057188630104,
-0.03208259120583534,
0.03518044948577881,
0.04760... |
dissociation\tof\tthe\tPAB-RBP\tcomplex\tand\tfiltration\tof\tapoprotein\t(apo)-RBP\tby\tthe\tglomerulus.\nThe\tplasma\tRBP\tconcentration\thas\tbeen\tshown\tto\tdecrease\tin\tstarvation-related\tmalnutrition.\nHowever,\tRBP\tlevels\talso\tfall\tin\tthe\tpresence\tof\tinflammatory\tstress\tand\tmay\tnot\timprove\twith | [
0.010704727843403816,
-0.09836407750844955,
0.023405248299241066,
0.005789507646113634,
-0.09452251344919205,
-0.007462246343493462,
0.07382243126630783,
0.0767865777015686,
0.01541974488645792,
0.021236151456832886,
0.10092376917600632,
0.01220425684005022,
0.028440766036510468,
0.0609393... |
refeeding.\tRBP\tmay\tnot\treflect\tprotein\tstatus\tin\tacutely\tstressed\tpatients.\tIt\tmay\teven\tbe\televated\nwith\trenal\tfailure\tbecause\tthe\tRBP\tis\tnot\tbeing\tcatabolized\tby\tthe\trenal\ttubule.\nRBP4\tis\tan\tadipocyte-derived\tpeptide\tof\tRBP\tthat\tinfluences\tglucose\thomeostasis\tand\tlipoprotein\n... | [
0.0038397496100515127,
-0.0777597725391388,
0.02529420703649521,
-0.020565437152981758,
-0.09487912058830261,
-0.007237419486045837,
0.06529219448566437,
0.0732189491391182,
-0.014090199023485184,
0.035105541348457336,
0.12281916290521622,
0.030134357511997223,
0.004033553879708052,
0.0493... |
metabolism.\tHuman\tclinical\n\ttrials\thave\tdemonstrated\tincreased\tRBP4\tlevels\tin\tobesity,\tinsulin\nresistance,\tgestational\tdiabetes,\tproliferative\tdiabetic\tretinopathy,\tand\tnondiabetic\tstage\t5\tchronic\nkidney\tdisease,\tischemic\tstroke,\tsuggesting\ta\tpossible\trelationship\tbetween\tthese\tconditi... | [
-0.013203699141740799,
-0.08475401997566223,
-0.00048368980060331523,
0.022571885958313942,
-0.10206081718206406,
-0.0028191031888127327,
0.0980796366930008,
0.07268612086772919,
-0.07172336429357529,
0.06301341205835342,
0.05061707645654678,
-0.032915160059928894,
-0.03900125250220299,
0.... |
clinical\ttrials\tare\tneeded\tto\tdefine\tthis\trelationship\t(\nXun\tet\tal,\t2018\n;\t\nPerduca\tet\tal,\t2018\n;\t\nKlisić\tet\tal,\n2017\n;\t\nZhou\tet\tal,\t2017\n). | [
-0.04975448548793793,
0.013224148191511631,
0.021445956081151962,
-0.08234037458896637,
-0.08942373842000961,
0.03844280168414116,
-0.0010720903519541025,
0.1059420257806778,
0.004907670430839062,
0.029682261869311333,
0.05606057494878769,
-0.024736624211072922,
-0.019580185413360596,
0.09... |
Transferrin\nTransferrin\n\tis\ta\tglobulin\tprotein\tthat\ttransports\tiron\tto\tthe\tbone\tmarrow\tfor\tproduction\tof\nhemoglobin\t(Hgb)\n.\tThe\tplasma\ttransferrin\tlevel\tis\tcontrolled\tby\tthe\tsize\tof\tthe\tiron\tstorage\tpool.\nWhen\tiron\tstores\tare\tdepleted,\ttransferrin\tsynthesis\tincreases.\tIt\thas\t... | [
-0.06282453238964081,
-0.0736120417714119,
-0.005818899255245924,
-0.06112176924943924,
-0.021327706053853035,
0.0343790166079998,
0.06910178810358047,
0.05481495335698128,
0.012047067284584045,
0.04160253703594208,
0.10757733136415482,
-0.02743137814104557,
-0.009665471501648426,
0.048008... |
than\talbumin.\tLevels\tdiminish\twith\tacute\tinflammatory\treactions,\tmalignancies,\tcollagen\n\tvascular\ndiseases,\tand\tliver\tdiseases.\tTransferrin\tlevels\treflect\tinflammation\tand\tare\tnot\tuseful\tas\ta\tmeasure\nof\tprotein\tstatus.\nImmunocompetence\nInflammation-related\tmalnutrition\tis\tassociated\tw... | [
0.012440820224583149,
-0.07238554954528809,
0.042562589049339294,
-0.0075411018915474415,
-0.11622177064418793,
0.005705188028514385,
0.08144886046648026,
0.0732569694519043,
-0.011399535462260246,
0.035890255123376846,
0.09343282133340836,
-0.033711571246385574,
-0.0018623232608661056,
0.... |
depressed\tcell-mediated\timmunity,\tphagocyte\tdysfunction,\tdecreased\tlevels\tof\tcomplement\ncomponents,\treduced\tmucosal\tsecretory\tantibody\tresponses,\tand\tlower\n\tantibody\taffinity.\tAssessing\nimmunocompetence\t(i.e.,\teosinophils)\tis\talso\tuseful\tin\tthe\tpatient\twho\tis\tbeing\ttreated\tfor\tallergi... | [
-0.006327563431113958,
0.012654799036681652,
0.03456861898303032,
0.060652222484350204,
-0.08932898193597794,
0.02782198041677475,
0.08509686589241028,
0.07792137563228607,
0.03418039157986641,
-0.0014876862987875938,
0.02363050915300846,
-0.019418319687247276,
0.020932944491505623,
0.0186... |
(see\t\nChapter\t25\n).\nThere\tis\tno\tsingle\tmarker\tfor\timmunocompetence\texcept\tfor\tthe\tclinical\toutcome\tof\tinfection\tor\nallergic\tresponse.\tLaboratory\tmarkers\twith\ta\thigh\tdegree\tof\tsensitivity\tinclude\tvaccine-specific\nserum\tantibody\tproduction,\tdelayed-type\thypersensitivity\n\tresponse,\tv... | [
0.0056663150899112225,
-0.039836425334215164,
0.030321523547172546,
-0.04895772412419319,
-0.02402474731206894,
-0.007672078441828489,
0.08583901077508926,
0.02539428323507309,
-0.005587726831436157,
0.08792499452829361,
0.09099425375461578,
-0.03172425180673599,
0.047318778932094574,
0.06... |
response,\tvaccine-specific\tor\ttotal\nsecretory\timmunoglobulin\tA\tin\tsaliva,\tand\tthe\tresponse\tto\tattenuated\tpathogens.\tLess\tsensitive\nmarkers\tinclude\tnatural\tkiller\tcell\tcytotoxicity,\toxidative\tburst\tof\tphagocytes,\tlymphocyte\nproliferation,\tand\tthe\tcytokine\tpattern\tproduced\tby\tactivated\... | [
0.0023226416669785976,
-0.07405690848827362,
0.025280380621552467,
-0.047391392290592194,
-0.08824976533651352,
0.017522364854812622,
0.07206905633211136,
0.0802907794713974,
0.010697009973227978,
0.11234506964683533,
0.04873345047235489,
-0.05051976069808006,
0.035672761499881744,
0.08755... |
markers\tis\tcurrently\tthe\tbest\tapproach\tto\tmeasuring\timmunocompetence.\nAssessment\tfor\tnutritional\tanemias\nAnemia\tis\ta\tcondition\tcharacterized\tby\ta\treduction\tin\tthe\tnumber\tof\terythrocytes\tper\tunit\tof\tblood\nvolume\tor\ta\tdecrease\tin\tthe\tHgb\tof\tthe\tblood\tto\tbelow\tthe\tlevel\tof\tusua... | [
-0.005391754675656557,
-0.06536444276571274,
-0.006001895759254694,
-0.02970784530043602,
-0.06862444430589676,
0.03319824859499931,
0.0914735496044159,
0.05747262388467789,
-0.05414485186338425,
0.06051414832472801,
0.07899438589811325,
-0.03490794077515602,
-0.009279165416955948,
0.03014... |
convention,\tanemia\tis\tdefined\tas\tHgb\tconcentration\tbelow\tthe\t95th\tpercentile\tfor\thealthy\treference\npopulations\tof\tmen,\twomen,\tor\tage-grouped\tchildren.\tAnemia\tis\tnot\ta\tdisease\n\tbut\ta\tsymptom\tof\nvarious\tconditions,\tincluding\textensive\tblood\tloss,\texcessive\tblood\tcell\tdestruction,\t... | [
0.004648589063435793,
-0.04715563729405403,
-0.03918961435556412,
-0.041920606046915054,
-0.0870075449347496,
-0.010503065772354603,
0.07073792815208435,
0.05531936138868332,
0.026062823832035065,
0.05465530604124069,
0.07114990800619125,
-0.031165484338998795,
0.01647438108921051,
0.03315... |
blood\tcell\tformation.\tIt\tis\tobserved\tin\tmany\thospitalized\tpatients\tand\tis\toften\ta\tsymptom\tof\ta\tdisease\nprocess;\tits\tcause\tshould\tbe\tinvestigated.\tClinical\tnutritionists\tmust\tdistinguish\tbetween\tanemia\ncaused\tby\tnutritional\tinadequacies\tand\tthat\tcaused\tby\tother\tfactors\t(i.e.,\tdeh... | [
0.017582010477781296,
-0.04179910197854042,
0.049047064036130905,
-0.008304687216877937,
-0.10125847905874252,
0.00947583094239235,
0.09449072182178497,
0.02269848994910717,
-0.03427483141422272,
0.038741584867239,
0.0809824988245964,
-0.006167227402329445,
-0.010157127864658833,
0.0402068... |
masking\nfalsely\tlow\tblood\tvalues).\tSee\t\nChapter\t31\n\tfor\tdiscussion\tof\tthe\tmanagement\tof\tanemias.\nClassification\tof\tanemia\nNutritional\tdeficits\tare\ta\tmajor\tcause\t\nof\tdecreased\tHgb\tand\terythrocyte\tproduction.\tThe\tinitial\ndescriptive\tclassification\tof\tanemia\tis\tderived\tfrom\tthe\t\... | [
-0.010628513060510159,
-0.0009418396512046456,
0.018280427902936935,
-0.013272980228066444,
-0.01755605824291706,
0.0270155668258667,
0.08557315170764923,
0.03846815600991249,
-0.04619971662759781,
0.04915981367230415,
0.05856519564986229,
-0.05005332827568054,
-0.015804927796125412,
0.028... |
hematocrit\t(Hct)\n\tvalue\tor\tCBC\tas\texplained\nin\t\nTable\t5.2\n.\tAnemias\tassociated\twith\ta\tmean\tRBC\tvolume\tof\tless\tthan\t80\n\tfl\t(femtoliters)\tare\nmicrocytic;\tthose\twith\tvalues\tof\t80\tto\t99\tfl\tare\tnormocytic;\tthose\tassociated\twith\tvalues\tof\t100\tfl\tor\nmore\tare\tmacrocytic\t(see\t\... | [
-0.017496177926659584,
-0.02741609700024128,
-0.00868394784629345,
-0.002970897825434804,
-0.05608215183019638,
0.0063885911367833614,
0.06771625578403473,
0.09593265503644943,
-0.007089676801115274,
0.021913563832640648,
0.04524010419845581,
-0.015679694712162018,
0.01577715203166008,
0.0... |
).\tData\tfrom\tthe\tCBC\tare\thelpful\tin\tidentifying\tnutritional\ncauses\tof\tanemia.\t\nMicrocytic\tanemia\n\tis\tassociated\tmost\toften\twith\tiron\tdeficiency,\twhereas\nmacrocytic\tanemia\n\tgenerally\tis\tcaused\tby\teither\tfolate-\tor\tvitamin\tB\n12\n–deficient\terythropoiesis. | [
-0.02249358780682087,
-0.027622031047940254,
-0.020327748730778694,
0.00986882857978344,
-0.06632966548204422,
0.03929057717323303,
0.07974319905042648,
0.06896038353443146,
-0.0629219263792038,
0.058340806514024734,
0.04036959260702133,
-0.022679578512907028,
-0.014105303213000298,
0.0214... |
12\n–deficient\terythropoiesis.\nHowever,\tbecause\tof\tthe\tlow\tspecificity\tof\tthese\tindexes,\tadditional\tdata\tare\tneeded\tto\tdistinguish\nbetween\tthe\tvarious\tnutritional\tcauses\tand\tnonnutritional\tcauses,\tsuch\tas\tthalassemia\ttrait\tand\nchronic\trenal\tinsufficiency.\tNormocytic\tanemia\tis\tassocia... | [
0.037398811429739,
-0.015547303482890129,
0.004181043244898319,
0.01927640289068222,
-0.09091035276651382,
0.03029286116361618,
0.0694064125418663,
0.07896048575639725,
-0.07629598677158356,
0.06355976313352585,
0.09891272336244583,
0.016503501683473587,
0.004949602298438549,
0.02920680679... |
anemia\tof\tchronic\tand\ninflammatory\tdisease\t(ACD)\n.\tThis\ttype\tof\tanemia\tis\tassociated\twith\tautoimmune\tdiseases,\nrheumatic\tdiseases,\n\tchronic\theart\tfailure,\tchronic\tinfection,\tHodgkin’s\tdisease\tand\tother\ttypes\tof\ncancer,\tinflammatory\tbowel\tdisease,\tkidney\tdisease\tand\tother\tchronic\t... | [
0.01549138780683279,
-0.06290678679943085,
0.039706502109766006,
0.016248341649770737,
-0.08907733857631683,
0.0330626517534256,
0.10991813987493515,
0.04499758034944534,
-0.030548254027962685,
0.07668066024780273,
0.05690078064799309,
-0.025768019258975983,
0.012898978777229786,
0.0444057... |
severe\ttissue\tinjury,\tand\tmultiple\tfractures.\tACD\tdoes\tnot\trespond\tto\tiron\tsupplementation.\nOther\tinformation\tfrom\tthe\tCBC\tthat\thelps\tdifferentiate\tthe\tnonnutritional\tcauses\tof\tanemia\nincludes\tleukocyte,\treticulocyte,\tand\n\tplatelet\tcounts.\tWhen\tlevel\tof\tleukocytes,\treticulocytes,\ta... | [
0.010000697337090969,
-0.034031469374895096,
0.008651962503790855,
-0.01908119022846222,
-0.10414239764213562,
0.009515063837170601,
0.11183373630046844,
0.10966910421848297,
-0.047137774527072906,
0.06886162608861923,
0.031107334420084953,
0.008994183503091335,
0.0027937781997025013,
0.02... |
platelet\tcounts.\tWhen\tlevel\tof\tleukocytes,\treticulocytes,\tand\nplatelet\tcounts\tare\tlow,\tthe\tpattern\tof\tresults\tsuggests\tmarrow\tfailure.\tElevated\tlevels\tof\tleukocytes,\nreticulocytes,\tand\tplatelet\tcounts\tare\tassociated\twith\tanemia\tand\tlikely\tcaused\tby\tleukemia\tor | [
-0.0028800207655876875,
-0.031030166894197464,
0.010614164173603058,
-0.05512635409832001,
-0.0726160779595375,
0.018975084647536278,
0.09610316902399063,
0.1000039353966713,
-0.007488108240067959,
0.05993518605828285,
0.06892771273851395,
-0.02917146123945713,
-0.004114465322345495,
0.028... |
infection.\tESR\ttesting\tis\tordered\twhen\tsymptoms\tare\tnonspecific\tand\tif\tinflammatory\tautoimmune\ndiseases\tare\tsuspected.\tReticulocytes\tare\tlarge,\n\tnucleated,\timmature\tRBCs\tthat\tare\treleased\tin\nsmall\tnumbers\twith\tmature\tcells.\tWhen\tRBC\tproduction\trates\tincrease,\treticulocyte\tcounts\ta... | [
0.0032452831510454416,
-0.06824727356433868,
0.014967057853937149,
-0.08271466940641403,
-0.08403442800045013,
-0.004827503580600023,
0.09007533639669418,
0.09895208477973938,
-0.008907011710107327,
0.09362760931253433,
0.07205784320831299,
-0.0056440578773617744,
0.020224643871188164,
0.1... |
increase.\tAny\ttime\tanemia\tis\taccompanied\tby\ta\thigh\treticulocyte\tcount,\televated\terythropoietic\nactivity\tin\tresponse\tto\tbleeding\tshould\tbe\tconsidered.\tIn\tsuch\tcases,\tstool\tspecimens\tcan\tbe\ttested\nfor\toccult\tblood\tto\trule\tout\tchronic\tGI\tblood\tloss.\tOther\tcauses\n\tof\ta\thigh\treti... | [
0.05971197783946991,
-0.06609787046909332,
0.060980767011642456,
-0.001473891083151102,
-0.1316819041967392,
-0.019543712958693504,
0.1363353729248047,
0.016646115109324455,
-0.06587912887334824,
0.08709964901208878,
0.06147808954119682,
-0.03308180347084999,
0.012850331142544746,
0.045747... |
of\ta\thigh\treticulocyte\tcount\tinclude\nintravascular\themolysis\tsyndromes\tand\tan\terythropoietic\tresponse\tto\ttherapy\tfor\tiron,\tvitamin\tB\n12\n,\nor\tfolate\tdeficiencies.\nNormocytic\tor\tmicrocytic\tanemia\tmay\tbe\tcaused\tby\tchronic\tor\tacute\tblood\tloss,\tsuch\tas\tfrom | [
0.04161493852734566,
-0.013896229676902294,
0.013251202180981636,
-0.023243771865963936,
-0.09791503101587296,
-0.021147647872567177,
0.07533899694681168,
0.075808085501194,
-0.07751108705997467,
0.06710678339004517,
0.03460058197379112,
-0.0074967509135603905,
-0.0013129196595400572,
0.03... |
recent\tsurgery,\tinjury,\tor\tfrom\tthe\tGI\ttract\tas\tindicated\tby\ta\tpositive\toccult\tstool\ttest.\tNote\tthat\tin\nthose\twith\themolytic\tanemias\tand\tearly\tiron\n\tdeficiency\tanemia,\tthe\tRBC\tsize\tmay\tstill\tbe\tnormal.\nMacrocytic\tanemias\tinclude\tfolate\tdeficiency\tand\tvitamin\tB\n12\n\tdeficienc... | [
0.020429305732250214,
-0.027889318764209747,
0.03777756914496422,
0.0030916661489754915,
-0.0769835039973259,
0.028782673180103302,
0.09911338239908218,
0.04571826756000519,
-0.024506624788045883,
0.07373097538948059,
0.08309517055749893,
0.0021710447035729885,
-0.0013884201180189848,
0.02... |
12\n\tdeficiency.\tThe\tpresence\tof\tmacrocytic\nRBCs\trequires\tevaluation\tof\tfolate\tand\tvitamin\tB\n12\n\tstatus.\tDNA\tsynthesis\tis\taffected\tnegatively\tby\ndeficiencies\tof\tfolic\tacid\tand\tvitamin\tB\n12,\n\tresulting\tin\timpaired\tRBC\tsynthesis\tand\tmaturation\tof\nRBCs.\tThese\tchanges\tcause\tlarge... | [
0.03542839735746384,
-0.09601002931594849,
0.0131649449467659,
-0.039037030190229416,
-0.11940094083547592,
0.025050530210137367,
0.04637749493122101,
0.00831884890794754,
-0.020051131024956703,
0.1100781187415123,
0.07998382300138474,
-0.017807213589549065,
0.02065647579729557,
0.02289257... |
to\tbe\treleased\tinto\tthe\tcirculation.\tAlthough\nvitamin\tB\n12\n–related\tanemia\tis\tcategorized\tas\ta\tmacrocytic\tnormochromic\tanemia,\tapproximately\n40%\tof\tthe\tcases\tare\tnormocytic.\nMarkers\tof\tiron\tdeficiency\tanemias | [
0.005387721583247185,
-0.04146836698055267,
-0.03738701716065407,
0.004080460872501135,
-0.05087867006659508,
0.02733275294303894,
0.09846577048301697,
0.09446331858634949,
-0.07164447009563446,
0.014299444854259491,
0.03984105959534645,
-0.016300329938530922,
0.016224760562181473,
0.02770... |
Hematocrit\tor\tpacked\tcell\tvolume\tand\themoglobin\nHct\tand\tHgb\tare\tpart\tof\ta\troutine\tCBC\tand\tare\tused\ttogether\tto\tevaluate\tiron\tstatus.\tHct\tis\tthe\nmeasure\tof\tthe\tpercentage\tof\tRBCs\tin\ttotal\n\tblood\tvolume.\tUsually\tthe\tHct\tpercentage\tis\tthree\ttimes\nthe\tHgb\tconcentration\tin\tgr... | [
0.015589764341711998,
-0.04715956747531891,
0.022652607411146164,
-0.02490767277777195,
-0.08457379788160324,
0.01226838305592537,
0.10976859927177429,
0.029767315834760666,
-0.014889094978570938,
0.06338533759117126,
0.06361190974712372,
-0.027515104040503502,
0.00641950499266386,
0.00780... |
count\tand\thydration\tstatus.\tIndividuals\tliving\tin\thigh\taltitudes\toften\thave\tincreased\tvalues.\tIt\tis\ncommon\tfor\tindividuals\tolder\tthan\tage\t50\tto\thave\tslightly\tlower\tlevels\tthan\tyounger\tadults.\nThe\tHgb\tconcentration\tis\ta\tmeasure\tof\tthe\ttotal\tamount\n\tof\tHgb\tin\tthe\tperipheral\tb... | [
0.030729351565241814,
-0.018735041841864586,
0.06490267813205719,
-0.049218859523534775,
-0.05478137359023094,
0.013421876356005669,
0.10931258648633957,
-0.03226609155535698,
-0.0007235174416564405,
0.10344139486551285,
0.08812392503023148,
-0.04888158664107323,
0.06176574155688286,
0.013... |
of\tHgb\tin\tthe\tperipheral\tblood.\tIt\tis\ta\nmore\tdirect\tmeasure\tof\tiron\tdeficiency\tthan\tHct\tbecause\tit\tquantifies\ttotal\tHgb\tin\tRBCs\trather\tthan\na\tpercentage\tof\ttotal\tblood\tvolume.\tHgb\tand\tHct\tare\tbelow\tnormal\tin\tthe\tfour\ttypes\tof\tnutritional\nanemias\tand\talways\tshould\tbe\teval... | [
0.021158386021852493,
-0.03993982449173927,
0.04160046577453613,
-0.008589339442551136,
-0.05873808264732361,
0.0030128727667033672,
0.10043579339981079,
0.006201361306011677,
-0.004115122836083174,
0.08258593827486038,
0.058934006839990616,
-0.012774682603776455,
0.03058473952114582,
0.03... |
history\t(see\t\nChapter\t31\n).\nSerum\tferritin\nFerritin\tis\tthe\tstorage\n\tprotein\tthat\tsequesters\tthe\tiron\tnormally\tgathered\tin\tthe\tliver\n(reticuloendothelial\tsystem),\tspleen,\tand\tmarrow.\tAs\tthe\tiron\tsupply\tincreases,\tthe\tintracellular\tlevel\nof\tferritin\tincreases\tto\taccommodate\tiron\t... | [
0.003907657228410244,
-0.06191364675760269,
0.04922514036297798,
-0.03514491766691208,
-0.10762526094913483,
0.005033837631344795,
0.05212032049894333,
0.04960886761546135,
0.015654753893613815,
0.0857759341597557,
0.09480641782283783,
-0.012058737687766552,
-0.005147629417479038,
0.075425... |
circulation.\tThis\tferritin\tcan\tbe\tmeasured\tby\tassays\tthat\tare\tavailable\tin\tmost\tclinical\tlaboratories.\nIn\tindividuals\twith\tnormal\n\tiron\tstorage,\t1\tng/mL\tof\tserum\tferritin\tis\tabout\t8\tmg\tof\tstored\tiron.\tIn\nhealthy\tadults,\tthe\tmeasurement\tof\tferritin\tthat\thas\tleaked\tinto\tthe\ts... | [
0.020464450120925903,
-0.032267965376377106,
0.028865138068795204,
-0.034463200718164444,
-0.09926556050777435,
-0.028406305238604546,
0.045405395328998566,
0.010753090493381023,
-0.013482756912708282,
0.04390034079551697,
0.08451733738183975,
-0.026532351970672607,
0.0851026102900505,
0.0... |
the\tsize\tof\tthe\tbody’s\tiron\tstorage\tpool.\nACD\tis\tthe\tprimary\tcondition\tin\twhich\tferritin\tfails\tto\tcorrelate\twith\tiron\tstores.\tACD,\ta\tcommon\nform\tof\tanemia\tin\thospitalized\tpatients,\toccurs\tin\tthose\twith\tcancer\tor\tinflammatory\n\tor\tinfectious\ndisorders.\tIt\toccurs\tduring\tinflamm... | [
0.02091471664607525,
-0.057739268988370895,
0.00009481694723945111,
-0.037837397307157516,
-0.09394935518503189,
-0.008105888962745667,
0.0896722748875618,
0.03199896961450577,
0.009283158928155899,
0.06997019797563553,
0.12002027779817581,
-0.00833110511302948,
0.05347242206335068,
0.0492... |
inadequate\tmobilization\tof\tiron\tfrom\tits\tstorage\tsites.\tIn\tthose\twith\tchronic\tinflammatory\tconditions\n(i.e.,\tarthritis)\tdepletion\tof\tstored\tiron\tdevelops\tpartly\tbecause\tof\treduced\tabsorption\tof\tiron\tfrom\nthe\tgut\tdue\tto\trelease\tof\thepcidin.\tAlso\tthe\tregular\tuse\tof\tnonsteroidal\ta... | [
0.040536992251873016,
-0.10068033635616302,
0.018670646473765373,
-0.013017836958169937,
-0.10022488981485367,
-0.034057602286338806,
0.06588702648878098,
0.060242585837841034,
-0.003742844332009554,
0.0882955864071846,
0.08490155637264252,
-0.03863832727074623,
0.021165695041418076,
0.076... |
drugs\tcan\ncause\toccult\tGI\tblood\tloss.\tACD\thas\tmany\tforms\tand\tmust\tbe\tdistinguished\tfrom\tiron\tdeficiency\nanemia\tso\tthat\tinappropriate\tiron\tsupplementation\tis\tnot\tinitiated.\nSerum\tiron\nSerum\tiron\n\tmeasures\tthe\tamount\tof\tcirculating\tiron\tthat\tis\tbound\tto\ttransferrin.\tHowever,\tit... | [
-0.0011994426604360342,
-0.0859968513250351,
0.02847982384264469,
-0.07296805828809738,
-0.11442531645298004,
0.030596766620874405,
0.08832661062479019,
0.02987348847091198,
-0.010987509973347187,
0.10298813134431839,
0.07668829709291458,
0.008851631544530392,
0.02956833690404892,
0.030587... |
relatively\tpoor\tindex\tof\tiron\tstatus\tbecause\tof\tlarge\tday-to-day\tchanges,\teven\tin\thealthy\tindividuals.\nDiurnal\n\tvariations\talso\toccur,\twith\tthe\thighest\tconcentrations\toccurring\tmidmorning\t(from\t6\tam\tto\n10\tam),\tand\ta\tnadir,\taveraging\t30%\tless\tthan\tthe\tmorning\tlevel,\toccurring\tm... | [
0.015844978392124176,
-0.04802276939153671,
0.06932787597179413,
-0.056936074048280716,
-0.11718754470348358,
-0.013731573708355427,
0.08749467879533768,
-0.00008083946886472404,
-0.02476027049124241,
0.03616243228316307,
0.11810265481472015,
-0.059826429933309555,
0.052934885025024414,
0.... |
should\tbe\tevaluated\tin\tlight\tof\tother\tlaboratory\tvalues\tand\trecent\tmedical\thistory\tto\tassess\tiron\nstatus.\nTotal\tiron-binding\tcapacity\tand\ttransferrin\tsaturation\nTotal\tiron-binding\tcapacity\t(TIBC)\n\tis\ta\tdirect\n\tmeasure\tof\tall\tproteins\tavailable\tto\tbind\tmobile\tiron | [
-0.02486012503504753,
-0.05178367346525192,
0.025521093979477882,
-0.06415808945894241,
-0.1184963807463646,
0.007888322696089745,
0.069742850959301,
0.03485758602619171,
-0.01563180796802044,
0.06778170168399811,
0.08096107095479965,
-0.04316490516066551,
0.04095848649740219,
0.0827122703... |
is\ta\tdirect\n\tmeasure\tof\tall\tproteins\tavailable\tto\tbind\tmobile\tiron\nand\tdepends\ton\tthe\tnumber\tof\tfree\tbinding\tsites\ton\tthe\tplasma\tiron-transport\tprotein\ttransferrin.\nIntracellular\tiron\tavailability\tregulates\tthe\tsynthesis\tand\tsecretion\tof\ttransferrin\t(i.e.,\ttransferrin\nconcentrati... | [
-0.008743977174162865,
-0.0852244645357132,
0.013845229521393776,
-0.03636367246508598,
-0.09092245995998383,
0.013773626647889614,
0.0631883516907692,
0.03515368327498436,
-0.003471044357866049,
0.06185932829976082,
0.1205039992928505,
-0.0034231527242809534,
0.03936799243092537,
0.077160... |
concentration\tincreases\tin\tthose\twith\tiron\tdeficiency).\nTransferrin\tsaturation\treflects\tiron\tavailability\tto\ttissues\t(bone\tmarrow\terythropoiesis).\n\tIt\tis\ndetermined\tby\tthe\tfollowing\tequation:\nIn\taddition,\twhen\tthe\tamount\tof\tstored\tiron\tavailable\tfor\trelease\tto\ttransferrin\tdecreases... | [
0.0003190388670191169,
-0.10699170082807541,
0.03298884630203247,
-0.006543473806232214,
-0.09976480156183243,
-0.001976827858015895,
0.09053144603967667,
0.0181718822568655,
0.0045308806002140045,
0.08865340054035187,
0.09543878585100174,
0.0004178121162112802,
0.024007057771086693,
0.082... |
dietary\tiron\tintake\tis\tlow,\tsaturation\tof\ttransferrin\tdecreases.\nThere\tare\texceptions\tto\tthe\tgeneral\trule\tthat\ttransferrin\n\tsaturation\tdecreases\tand\tTIBC\tincreases\nin\tpatients\twith\tiron\tdeficiency.\tFor\texample,\tTIBC\tincreases\tin\tthose\twith\thepatitis.\tIt\talso\tincreases | [
-0.001283561927266419,
-0.07732708007097244,
0.03620785474777222,
0.008027439005672932,
-0.077740877866745,
-0.00979394931346178,
0.06409066915512085,
0.10402756184339523,
-0.05515339598059654,
-0.0037532015703618526,
0.08038729429244995,
-0.016717731952667236,
-0.02622424066066742,
0.0498... |
in\tpeople\twith\thypoxia,\twomen\twho\tare\tpregnant,\tor\tthose\ttaking\toral\tcontraceptives\tor\treceiving\nestrogen\treplacement\ttherapy.\tOn\tthe\tother\thand,\tTIBC\tdecreases\tin\tthose\twith\tmalignant\tdisease,\nnephritis,\tand\themolytic\tanemias.\tFurthermore,\tthe\tplasma\tlevel\n\tof\ttransferrin\tmay\tb... | [
-0.004339881706982851,
-0.009855227544903755,
0.013053832575678825,
-0.026560088619589806,
-0.07005906850099564,
0.00958154909312725,
0.048727311193943024,
0.027406038716435432,
0.0006443588063120842,
0.06751985102891922,
0.10533106327056885,
0.00403179507702589,
0.03948723524808884,
0.004... |
of\ttransferrin\tmay\tbe\tdecreased\tin\nthose\twith\tmalnutrition,\tfluid\toverload,\tand\tliver\tdisease.\tThus\talthough\tTIBC\tand\ttransferrin\nsaturation\tare\tmore\tspecific\tthan\tHct\tor\tHgb\tvalues,\tthey\tare\tnot\tperfect\tindicators\tof\tiron\tstatus.\nAn\tadditional\tconcern\tabout\tthe\tuse\tof\tserum\t... | [
-0.025152599439024925,
-0.044132404029369354,
0.00702018104493618,
-0.04570448026061058,
-0.05812826752662659,
-0.010963608510792255,
0.10175789147615433,
0.018881283700466156,
0.016976967453956604,
0.046119578182697296,
0.06795336306095123,
-0.020778149366378784,
0.04471772909164429,
0.02... |
normal\tvalues\tpersist\tuntil\tfrank\tdeficiency\tactually\tdevelops.\tThus\n\tthese\ttests\tcannot\tdetect\ndecreasing\tiron\tstores\tand\tiron\tinsufficiencies.\nTests\tfor\tmacrocytic\tanemias\tfrom\tB\tvitamin\tdeficiencies\nMacrocytic\tanemias\tinclude\tfolate\tdeficiency\tand\tvitamin\tB\n12\n\tdeficiency.\tThe\... | [
0.032144587486982346,
-0.041437432169914246,
0.01591636799275875,
0.015999112278223038,
-0.0634925439953804,
-0.00476016104221344,
0.06359099596738815,
0.05508119985461235,
-0.06615713983774185,
0.06762396544218063,
0.10120046138763428,
-0.03734083101153374,
-0.006664821412414312,
0.042302... |
12\n\tdeficiency.\tThe\tnutritional\tcauses\tof\nmacrocytic\tanemia\tare\trelated\tto\tthe\tavailability\tof\tfolate\tand\tvitamin\tB\n12\n\tin\tthe\tbone\tmarrow\tand\nrequire\tevaluation\tof\tboth\tnutrient\tlevels\tand\tmethyl\tmalonic\n\tacid,\tan\tintermediate\tmetabolites\tof\nvitamin\tB\n12\n\tmetabolism.\tBoth\... | [
0.017080917954444885,
-0.06273026764392853,
0.027468817308545113,
-0.020920949056744576,
-0.04860260337591171,
0.033121105283498764,
0.06634002178907394,
0.03042645938694477,
-0.03235267102718353,
0.05806703120470047,
0.09689123183488846,
-0.03121195174753666,
0.0014037953224033117,
0.0256... |
thymidine\tmonophosphate.\tFolate\tand\tvitamin\tB\n12\n\tare\tused\tat\tdifferent\tsteps\tof\tthe\tsynthetic\npathway.\tImpaired\tRBC\tsynthesis\toccurs\tand\tlarge,\tnucleated\tRBCs\tthen\tare\treleased\tinto\tthe\ncirculation\t(see\t\nChapter\t31\n).\nAssessing\tfolate\tand\tvitamin\tB\n12\n\tstatus\nEvaluation\n\tf... | [
-0.023997578769922256,
-0.05827837437391281,
0.0388643853366375,
-0.04676802083849907,
-0.03487872704863548,
0.029957620427012444,
0.07867944985628128,
0.0516798309981823,
-0.047877006232738495,
0.10192208737134933,
0.07514192909002304,
-0.026279814541339874,
0.026629814878106117,
0.013926... |
12\n\tdeficiency\tin | [
0.051108360290527344,
-0.0233549103140831,
-0.06329597532749176,
-0.023073045536875725,
-0.10238576680421829,
0.03579401597380638,
0.11782094836235046,
0.06013519689440727,
-0.03266448527574539,
0.04212464392185211,
0.05018199607729912,
-0.04657450318336487,
-0.023943481966853142,
0.029302... |
blood.\tThey\tcan\tbe\tassayed\tusing\ttests\tof\tthe\tability\tof\tthe\tpatient’s\tblood\tspecimen\tto\tsupport\tthe\ngrowth\tof\tmicrobes\tthat\trequire\teither\tfolate\tor\tvitamin\tB\n12\n,\tor\tradiobinding\tassays,\tor\nimmunoassays.\nSerum\thomocysteine.\nFolate\tand\tvitamin\tB\n12\n\tare\trequired\tfor\tthe\ts... | [
-0.014285690151154995,
-0.06587424874305725,
-0.0014430521987378597,
-0.054208915680646896,
-0.15372683107852936,
0.020266547799110413,
0.04691511392593384,
0.04739084094762802,
0.00690104253590107,
0.05685111880302429,
0.08250320702791214,
0.023982500657439232,
0.003544305684044957,
0.040... |
are\trequired\tfor\tthe\tsynthesis\tof\tS-adenosylmethionine\t(SAM),\n\tthe\nbiochemical\tprecursor\tinvolved\tin\tthe\ttransfer\tof\tone-carbon\t(methyl)\tgroups\tduring\tmany\nbiochemical\tsyntheses.\tSAM\tis\tsynthesized\tfrom\tthe\tamino\tacid\tmethionine\tby\ta\treaction\tthat\nincludes\tthe\taddition\tof\ta\tmeth... | [
-0.03815632686018944,
-0.07236853241920471,
0.012165497988462448,
-0.07246990501880646,
-0.09757405519485474,
0.03967900201678276,
0.038951326161623,
0.016506806015968323,
-0.0013953042216598988,
0.10609723627567291,
0.09960820525884628,
-0.06880404055118561,
0.0053639099933207035,
0.02151... |
or\tATP).\tFor\texample,\twhen\tSAM\tdonates\ta\tmethyl\tgroup\tfor\tthe\tsynthesis\tof\tthymidine,\tcholine,\ncreatine,\tepinephrine,\n\tand\tprotein\tand\tDNA\tmethylation,\tit\tis\tconverted\tto\tS-adenosylhomocysteine.\nAfter\tlosing\tthe\tadenosyl\tgroup,\tthe\tremaining\t\nhomocysteine\n\tcan\tbe\tconverted\teith... | [
0.027429282665252686,
-0.10897079110145569,
-0.014769372530281544,
-0.04747761785984039,
-0.06371697038412094,
0.027394704520702362,
0.01434377022087574,
0.012790756300091743,
0.029237346723675728,
0.06525528430938721,
0.12606945633888245,
-0.02531932294368744,
0.0014931515324860811,
0.039... |
homocysteine\n\tcan\tbe\tconverted\teither\tto\tcysteine\tby\nthe\tvitamin\tB\n6\n–dependent\ttranssulfuration\tpathway\tor\tback\tto\tmethionine\tin\ta\treaction\tthat\tdepends\non\tadequate\tfolate\tand\tvitamin\tB\n12\n.\nWhen\teither\tfolate\tor\tvitamin\tB\n12\n\tis\tlacking,\tthe\thomocysteine-to-methionine\treac... | [
0.004139301832765341,
-0.0963452160358429,
0.007217650301754475,
-0.0018039245624095201,
-0.09999453276395798,
0.06544262915849686,
0.04551784694194794,
0.01715061068534851,
0.00855252891778946,
0.03600984066724777,
0.11099071800708771,
0.01132249180227518,
0.009341752156615257,
0.02260593... |
12\n\tis\tlacking,\tthe\thomocysteine-to-methionine\treaction\n\tis\tblocked,\ncausing\thomocysteine\tto\tbuild\tup\tin\tthe\taffected\ttissue\tand\tspill\tinto\tthe\tcirculation.\tThe\tvitamin\tB\n6\n–\ndependent\ttranssulfuration\tpathway\tcan\tmetabolize\texcess\thomocysteine.\tHomocysteine\thas\tbeen\nshown\tto\tbe... | [
0.07006112486124039,
-0.08925586193799973,
0.037242718040943146,
-0.02030906453728676,
-0.17585623264312744,
0.030200693756341934,
0.0775671899318695,
-0.00017481061513535678,
0.0030875953380018473,
0.04230125620961189,
0.06986812502145767,
-0.00310921436175704,
0.03196879103779793,
0.0170... |
shown\tto\tbe\tsensitive\tto\tfolate\tand\tvitamin\tB\n12\n\tdeficiency.\nTherefore\tan\televated\thomocysteine\tlevel\tindicates\teither\tgenetic\tdefects\tinvolved\tin\tthe\tenzymes\nthat\tcatalyze\tthese\treactions,\n\tor\ta\tdeficiency\tin\tfolate,\tvitamin\tB\n12\n,\tor\tvitamin\tB\n6\n.\tResearch\tindicates | [
0.06884242594242096,
-0.05063093081116676,
0.045287806540727615,
-0.036636386066675186,
-0.0693974643945694,
0.03882995620369911,
0.08395615965127945,
-0.01074786763638258,
0.012802602723240852,
0.09466271847486496,
0.08937069028615952,
-0.031031183898448944,
0.04344344139099121,
0.0661655... |
12\n,\tor\tvitamin\tB\n6\n.\tResearch\tindicates\nthat\tseveral\tfolate\tgene\tpolymorphisms\taffecting\tthe\tmethylation\tof\tfolate\tand\tB\n12\n\tcontribute\trisk\tfor\nseveral\tchronic\tcardiovascular\tand\tneurologic\tdisorders\t(\nKagawa\tet\tal,\t2017\n;\tsee\t\nChapters\t6\n\tand\n42\n).\nFolate\tassessment.\nF... | [
-0.027157651260495186,
-0.012730460613965988,
0.049530044198036194,
-0.0399307981133461,
-0.05189145356416702,
0.048057667911052704,
0.0566253624856472,
0.009370705112814903,
-0.01381436362862587,
0.07406016439199448,
0.12852682173252106,
-0.07368217408657074,
-0.021923761814832687,
0.0381... |
and\n42\n).\nFolate\tassessment.\nFolate\tmost\toften\tis\tmeasured\t\nsimultaneously\tin\twhole\tblood\twith\tits\tcombined\tamount\tfrom\tplasma\nand\tblood\tcells,\tand\tin\tthe\tserum\talone.\tThe\tdifference\tbetween\t\nwhole-blood\tfolate\tand\tserum\tfolate\nlevels\tthen\tis\tused\tto\tcalculate\ttotal\tRBC\tfol... | [
0.04777808487415314,
-0.012273155152797699,
0.046256471425294876,
-0.053709037601947784,
-0.12727871537208557,
-0.04794170334935188,
0.053207188844680786,
-0.02746342122554779,
-0.005686817225068808,
0.0685596838593483,
0.0989956259727478,
-0.032482683658599854,
0.019113842397928238,
0.012... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.