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BioData-CellLine_annotated

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PMC3035438
Compared to the parental sequence of CX13 before expansion, 100% of the sequence patterns analyzed at the IgL locus and 54% at the IgH locus showed alterations, the majority of which could be attributed to gene conversion events (Figure 2D).
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PMC10547921
Among them, the asymmetric ligand 2,3 cGAMP has the highest binding affinity with STING (Fig. 16B).
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PMC7081114
A and B: Fluorescence images of cells for each day post-transfection.
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PMC11522251
Furthermore, it has been demonstrated that, in a small percentage of patients, KRAS amplification is the cause of cetuximab resistance, which is linked to a low response to anti-EGFR treatment .
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PMC11424574
Specific cDNAs were amplified using the GoTaq qPCR Master Mix reagent (Thermo Fisher Scientific) using specific PCR primers for MTA2, uPA, and GAPDH with the following sequences: MTA2-Forward, 5’- TGTACCGGGTGGGAGATTAC-3’; MTA2-Reverse, 5’-TGAGGCTACTAG AAATGTCCCTG-3’; uPA-Forward, 5’-CCGCTTTCTTGCTGGTTGTC-3’; uPA-Reverse, 5’- TATTGTCGTTCGCCCTGGTG-3’; GAPDH-Forward, 5’-CATCATCCCTGCCTCTACTG -3’; GAPDH-Reverse, 5’-GCC TGCTTCACCACCTTC-3’.
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PMC11574271
Luciferase reporter constructs containing either the wild-type or mutated RON 3β€²UTR were introduced into 293 T cells in conjunction with miR-659-3p mimics or control mimics, and luciferase activity was measured 24 h after transfection.
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PMC11683240
As such, this mouse strain was used to determine the effect of B. pertussis infection on Ξ±1AT expression and the impact of exogenous Ξ±1AT administration in infant disease.
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PMC9429973
The overall response rate (ORR, assessed by investigator) and progression-free survival (PFS) were estimated 1 and 2 years after the first intake of VEN in patients with at least one follow-up visit in the study (evaluable population).
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PMC9429973
Primer walking and breakpoint spanning PCR were used to validate newly detected aberrations by OGM in selected cases.
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PMC11697703
Overall, miRs-193b-365 LoF in deep-layer neuron cultures results in increased MAPK8 signal, and miRs-193b-365 GoF in superficial-layer neurons results in decreased MAPK8 signal (Figure 2O).
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PMC11738017
Dot plot representing the ratio of sBCMA (ng/mL) to membrane BCMA (mBCMA) MFI levels at 48- and 96-hour time point. (
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PMC10470467
p < 0.01; ****p < 0.0001.
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PMC11680982
The current investigation demonstrated a significant relationship between hsa-miR-23a-5p expression in low HR/HER2-low breast cancer and neratinib, affecting CDK4/6 inhibitor and endocrine therapy.
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PMC9429973
Results: The genotypes have been classified into three groups according to the number of Ξ± globin genes and the severity of the alteration in the Ξ² globin gene.
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PMC11350568
This underscores the pronounced efficacy of AptG-1 in degrading the target protein.
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PMC5925824
Panel a: Jurkat-NFAT reporter assay: Each data point represents the average of two technical replicates, with error bars representing the SD.
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PMC9429973
Methods: In 118 patients with IE, regularly followed in our surgery, we used a gene panel for NGS composed by fifteen genes: JAK2, EGLN1 (PHD2), EPO-R, FTL, FTH, ASXL1, HFE, HFE2, TFR2, HAMP, SLC40A1, SLC11A2, VHL, BPMG, EPAS1 (HIF-2Ξ±).
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PMC7868205
The average crystalline size of the AgNPs was calculated using the Debye–Scherrer’s equation: D = KΞ»/Ξ² cosΙ΅.
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PMC11635519
Following that, cells were exposed to puromycin selection for 48 h to eliminate cells that were not infected.
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PMC10024132
VAL cells were pre-treated with 2.5 ΞΌM zoledronic acid (ZA) for 24 h and then used as target cells at an E/T ratio of 3:1 (D); data are shown as mean Β± SD from three different experiments. *
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PMC8633974
CRISPR Transgene expression was measured by reverse-transcriptase quantitative PCR (RT-qPCR) and determined to be above detection limits (Figure 3a).
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PMC11723947
e Volcano plot showing results of differential gene expression analyses between Treg that had been co-injected with WT or HP1Ξ± KO naive CD4 T cells.
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PMC11541409
For wild-type GISTs, ADC (DS-6157a) and kinase inhibitor (Olverembatinib) provide potential to treat these TKI-resistant GISTs.
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PMC9777812
These results were consistent with the previous studies.
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PMC3995603
The data processor used LC Solution software (version 1.24, Shimadzu Co., Kyoto, Japan).
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PMC7192625
We demonstrate the approach using published epigenomic and chromatin structure datasets in haematopoietic cells, including a collection of gene expression, DNA methylation and histone modifications data in primary healthy myeloid cells from hundreds of individuals.
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PMC11686380
All protocols for animal handling and treatment were reviewed and approved by the Animal Care and Use Committee of the Institute for Developmental Research, Aichi Developmental Disability Center (approval number: 2019–013).
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PMC11387401
The identified RNA interaction partners per protein were used as input for the webtool DAVID 2021 (Sherman et al, 2022) for gene ontology enrichment analysis with GO BP_DIRECT, CC_DIRECT, and MF_DIRECT.
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PMC9429973
Furthermore, AML-LTS had significantly impaired kidney function, as assessed by the glomerular filtration rate (eGFR) estimated using the CKD-EPI-formula.
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PMC9429973
Multivariate analysis is ongoing.
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PMC11727000
Biotinylation and BioID pulldowns were performed in duplicate as described .
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PMC10079526
Hypomethylating drug 5-Aza-2’-deoxycytidine (5-Aza-2’) enhances transcription of tumor suppressor genes and induces replication errors via entrapment of DNMT1, yielding DNA-protein crosslinks.
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PMC6901583
b Flow cytometric analysis and quantification of the expressions of CD206/HLA-DR in macrophages treated with medium collected from the indicated cells for 24 h. c Flow cytometric analysis and quantification of the expressions of CD163/CD86 in macrophages treated with medium collected from the indicated cells for 24 h. d IHC staining evaluating macrophages with anti-F4/80 as indicating in tumor of nude mice.
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PMC11618052
Yield: 0.25 g (72%), white solid, m.p: 148–150 Β°C, Rf.
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PMC9352806
For the impacts of BMS on worm size, locomotive activities, growth rate and lifespan, L1 worms were treated with BMS (100 ΞΌg/mL and 200 ΞΌg/mL) for 48 h. Worm length(C) and worm width (D) were analyzed by Image J software (n > 30 worms per group).
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PMC9250505
Hence, the densitometric analysis showed that the ratio of pBADS99/BAD decreased after the forced expression of pBADS99A.
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PMC8041314
From these 48 triple ABCB1, ABCC1, and ABCG2 inhibitors, 35 could be categorized into six different scaffolds: (i) 4-anilinopyrimidine, (ii) pyrrolo[3,2-d]pyrimidine, (iii) pyrimido[5,4-b]indole, (iv) quinazoline, (v) quinoline, and (vi) thieno[2,3-b]pyridine.
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PMC10996034
no. AF0231; Beyotime Institute of Biotechnology; anti-ZYX: 1:100 dilution; cat.
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PMC11462673
Moreover, the identification and targeting of enhancers provide additional treatment approaches.
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PMC11547972
Superior efficacy of co-treatment, compared to monodrug exposure, was also seen for cell cycling, with an enhanced G0/G1 and diminished G2/M phase in A498 cells.
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PMC11190538
The amino acid content of C-PC was analyzed via Agilent 1260 series HPLC analysis according to Campanella et al. and Jajić et al. .
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PMC9964654
TBA[Au(cdc)2] analysis was performed in a SUPELCO column (Discovery, Seattle, WA, USA) BIO Wide Pore 300 Γ…, C18; 25 cm Γ— 4.6 mm, 5 Β΅m (Sigma-Aldrich, St. Louis, MI, USA) at a flow rate of 1 mL/min, using a gradient method: from 60%A/40%B to 10%A/90%B in 15 min.
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PMC4485786
Figure 3.Influence of FcIL-7, NHS-IL12/FcIL-7, and NHS-IL12/IL-2MAB602 on innate immunity. (
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PMC9878278
As seen in Figure 1C, ZIKV induced the mRNA expression of PRRs including MDA5, RIG-I, and TLR3 in SC that correlated with significant induction in IFN-Ξ².
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PMC11621493
Data of experiments performed in triplicate or more are presented as mean Β± SD.
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PMC11791432
The flowchart of the present study is shown in Fig. 1.
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PMC11786704
Apoptosis detection by flow cytometry and TUNEL assay: NIH3T3 cells were incubated in 24-well plates for 24 h, treated with 850 mM Hβ‚‚Oβ‚‚ for 12 h, and then incubated with varying concentrations of PC capsules for another 12 h. Cells were collected, washed with PBS, stained with Annexin V-FITC and PI, and analyzed by flow cytometry using FlowJo software.
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PMC9429973
None of the analyzed amino acid positions in HLA-DRB1 pockets was statistically enriched neither in ALL or AML.
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PMC11538390
Briefly, HEKn cells were electroporated using the Amaxa Cell Line Nucleofector Kit V (Lonza, Catalog no. VCA-1003) and the Nucleofector I instrument (Lonza) program T-25.
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PMC11703992
The study incorporated a total of 2.1 million SNP loci and 35 blood and urine metabolites for a comprehensive genome-wide association analysis.
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PMC11806106
This might support the conclusion that more than one conformation is induced by these agonists as previously reported based on single molecule FRET assays in purified MOR.
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PMC9739791
The active catalyst particle was determined by measuring riboflavin fluorescence lifetime in the MES buffer and in the presence or absence of Pt(IV) prodrug.
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PMC11486946
The intensity of the anti-phosphorylated antibody was normalized to that of the anti-protein antibody.
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PMC9119314
No toxicity was seen for any of the analogues up to the highest dose of 100 mg/kg/dose (Supplementary Figure S8 ).
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PMC9895440
Next, we re-analyzed published single-cell RNA sequencing data of melanoma TILs.
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PMC11472569
The transfer of multiple molecules, such as miRNAs, gangliosides, and proteins, by EVs has been found to affect neurodegeneration.
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PMC11785489
For this, we examined a different antigen, the β€œNLV-” peptide from the cytomegalovirus (CMV) antigen pp65 presented on HLA-A*02:01.
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PMC10976516
Therefore, it is essential to develop new methods for early lung cancer diagnosis as well as novel efficient therapies to treat lung cancers in their advanced stages.
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PMC9532503
Experiments were started with an initial seed culture of 0.5 Γ— 10 cells/mL in cell culture volume of 3750 mL comprising 10 mL/L U1 feed, 2.5 mL/L U2 feed, 20 mL/L CHO feed, 1 mL/L TE mix, and 1 mL/L lipid mix on day 0.
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PMC11478724
It is important to note that after 48 h of treatment, the ROS produced was found to be 2.342 times higher than after 24 h of treatment with PMX (P < 0.0001) [Figure 2b].
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PMC8913139
Cell proliferation, migration, and invasion were detected by CCK-8 assay and Transwell assay.
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PMC11721295
We confirmed these changes in 2 additional lung cancer cell lines, derived either from the L-iKRAS model (LC3-545), or from the KP GEMM (KPL-86), depicted in Supplemental Figure 5, B and C, respectively.
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PMC11412721
RT-qPCR analysis of indicated DEGs from spleens of 4–6-week-old Trp53 EΞΌ-Myc males, Trp53 EΞΌ-Myc males, Trp53 EΞΌ-Myc females, and Trp53 EΞΌ-Myc females.
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PMC6024716
After two days, cell culture media were replaced with selection media (culture media supplemented with zeocin 200 Β΅g/mL), and samples were collected for analysis on day three and day five.
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PMC9429973
Summary/Conclusion: As the largest adult LCH cohort with thyroid gland involvement to date, we found that patients with thyroid gland involvement had different clinical characteristics, genetic profiles and outcomes than patients without thyroid gland involvement.
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PMC11576293
The results are shown in Table 3.
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PMC9429973
The primary endpoint was RBC transfusion independence (RBC-TI) β‰₯8 wk during wk 1–24.
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PMC11759543
Vorinostat were dissolved in dimethyl sulfoxide (DMSO) at stock concentration of 100 mM. Z-VAD-FMK, Z-IETD-FMK, and Ac-LEHD-CMK were dissolved in DMSO at stock concentration of 40 mM. Cell viability was performed using 3-(4,5-dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium (MTT; USB, Austria).
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PMC9429973
Summary/Conclusion: We demonstrate that TLX3 cooperates with FLT3-ITD in vivo and in vitro in a pro-T-cell context.
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PMC11748363
Ten compounds had solubility issues and precipitated in the testing medium, making the determination of their exact IC50 and accurate SI values not feasible.
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PMC11519583
g Fluorescence intensity of SPiDER-Ξ²Gal in MPs treated with the indicated siRNAs was monitored by flow cytometric analysis (n = 3).
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PMC9429973
Aims: We hypothesized that dual CRLF2 targeting with ruxolitinib and cellular immunotherapy could improve anti-leukemia activity against CRLF2-rearranged (R) DS-ALL.
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PMC11495567
Fluorescence intensities increased as the concentration of the PCAIs increased with NSL-YHJ-2-27 (3 ΞΌM) significantly increasing active caspase levels by 124 Β± 35% (Fig 5D).
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PMC9261184
Investigators detected methane concentrations within this nitrogen purge in two out of the four loading arms, but there was insufficient time to quantify prior to disconnection.
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PMC11394730
Poor Man’s Treacle is a member of the Amaryllidaceae family, which includes garlic (Allium sativum L.).
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PMC9119314
Compounds were then added at a range of concentrations to each well, and the plates were then incubated for a further 96 h. After 96 h, the culture medium was removed and 200 ΞΌL of 0.5 mg ml MTT solution (Sigma) in the complete medium was added to each well.
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PMC10565698
Hence, we selected circUSP10 for follow-up studies.
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PMC9583612
Averaging emissions from each site across all measurements, we calculate average tank emission rates of 597 and 239 scfh in basin A and basin B, respectively.
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PMC5600151
Tri-block modifications combine different blocks with different properties together, utilizing their advantages, while minimizing some of their pitfalls.
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PMC11673128
In fact, antibodies against ALK were found in patients with ALK-rearranged ALCL and NSCLC, and a CD8 cytotoxic T lymphocyte (CTL)-mediated response to ALK peptides was documented in peripheral blood lymphocytes (PBLs) from healthy donors .
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PMC11745823
Currently, RIT1 has been found to be crucial in neuron morphogenesis, differentiation, survival and development .
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PMC8759873
Repeat step f-times.
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PMC7757104
All experiments were performed in triplicate.
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PMC9429973
Summary/Conclusion: CC-99282 monotherapy showed a manageable safety profile and demonstrated promising efficacy in heavily pretreated pts with R/R NHL.
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PMC11740399
However, no study has reported the relationship between SRT3025 and PKM2.
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PMC11641532
Our trajectory analysis revealed that HSD3B7 expression was upregulated in the later stages of pseudotime, suggesting its involvement in tumor progression.
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PMC11604015
C: For autologous CAR-T cells, CAR molecules can also be transfected to the contaminated tumor cells, which may cause antigen escape Challenges of CAR-T cell therapy for T cell-derived malignancies.
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PMC9429973
The most common adverse events (AEs) were hematological toxicities; grade 3/4 neutropenia was detected in 6 patients (40%), thrombocytopenia in 3 patients (20%), lymphopenia in 4 patients (27%) and leukopenia in 2 patients (13%).
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PMC11267830
This study aimed to evaluate the therapeutic potential of indisulam in T-ALL, elucidate its underlying mechanisms and explore the role of the RBM39 gene.
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PMC11699042
We additionally combined our transcriptomic data with that of Liu et al. and observed a specific clustering of our HeLa strains with their HeLa-CCL2 strains, indicating a likely common origin (Fig. 1g).
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PMC11535726
Our phylogenetic analyses reveal that our new species belong to Kirschsteiniothelia with stable support values and, in particular, is closely related to K.crustacea.
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PMC9429973
Therapy includes redcelltransfusion, iron chelation therapy, interferon alpha(INF alpha) and allogenic stem cell transplantation.
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PMC7602170
Most GISTs are strongly positive for CD117 (Figure 1D), 10% of them are weakly or focally positive, and less than 5% of them may be negative .
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PMC10538569
Recombinant lentivirus titers were determined as previously described (37).
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PMC11568601
To further confirm our findings, IRE1 was overexpressed in 143B cells, which enhanced the expression of CHOP and apoptosis-associated proteins, cleaved caspase-3 and cleaved PARP1.
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PMC11541241
The involvement of BcFKBP12 in host colonization may diverge between different strains.
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PMC11763126
USP5 is a deubiquitinase that can inhibit the ubiquitination and degradation of substrate proteins .
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PMC10213179
Functional effect of ATOP on EphA2 tumor cell lines (A) Quantification of the colony formation assay.
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PMC5600151
Compared to linear PLLs with the same amount of lysine residues, dendritic PLLs have a much higher transfection efficiency, even though linear PLLs condense DNA molecules better.
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PMC9812014
The analysis of all these literature materials resulted in shortlisting over a hundred different alkaloids of both natural and synthetic nature which were active against Twenty-Eight (28) different pathogenic viruses.
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