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PMC11144200
In the meantime, the low PDI of these liposomes (Supplementary Table S1) suggests a very homogeneous dispersion of them.
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PMC11704135
Different letters within the same column represent significant differences at P < 5% DPPH radical scavenging activity (%) of the synthesized pyrimidine derivatives.
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PMC10713411
In KIRC cohort, the differential expression and prognosis prediction performance of 9 PRPCDGs, and the survival difference corresponded with the results described previously (Figure 4A–4C).
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PMC9429973
Aims: The objective of the present study was to analyze the efficacy and safety of Gilteritinib and Quizartinib in R/R FLT3-mutated AML in real-life context.
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PMC4485786
K01/07 and K06/11).
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PMC7987994
The 100% value represents the mean value of these control measurements.
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PMC9473868
BAI significantly inhibited colony formation ability of SW982 cells at the concentration of 25 μM, 50 μM, 75 μM, and 100 μM. These results suggested that BAI could significantly inhibit cell proliferation and viability in human synovial sarcoma SW982 cells.
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PMC8913139
In addition, ROCK1 expression was inhibited by miR-448 upregulation and promoted by miR-448 downregulation in A-172MG cells (P < 0.01, Figure 3(c)).
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PMC9429973
Results: Median age was 64 years, 8% were over 70 years old and 68% were male.
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PMC10470467
Furthermore, due to the lack of accurate prognostic statistical tools (3), diagnosing and treating ES patients remains difficult.
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PMC11011837
From 13 to 15 min, an isocratic gradient was maintained, with A at 52% and B at 48%.
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PMC9532503
The synthetic DNA fragments of the LC and HC of the antibody were linked to human T-cell leukemia virus (HTLV) 5′-UTR and cloned separately into the expression vectors pMOZ-G62 and pMOZ-G82, which are modified vectors based on pSV2-neo (ATCC®37149) and pSV2-dhfr (ATCC®37146) vectors respectively.
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PMC11723947
i, k Percentage of activated T cells expressing PD-1 (i) or LAG3 (k) (left) and average immune checkpoint expression per cell (right).
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PMC10329074
E and F) The proportion of apoptotic cells in ACHN cell line was assessed by flow cytometry.
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PMC11653552
Lastly, the preliminary data suggest that TAZ overexpression negatively regulates Che-1 expression, supporting the hypothesis of an inverse correlation between these proteins in MM.
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PMC11033180
Mutant mice expressing a truncated form of Sema5A exhibit increased defecation, suggesting the involvement of Sema5A in the regulation of gut motility.
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PMC10142392
Similarly, X. Zhang and colleagues have successfully synthesized linear-hyperbranched amphiphilic block copolymers, mPEG-(hb-PG)-g-PCL, with multiple arms using a simple two-step ring-opening polymerization strategy.
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PMC11803918
Photosensitive hybrid γδ-T exosomes induced synergistic cancer cell death. (
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PMC11269933
Therefore, we suggest that the phosphorylation of PK can rapidly activate the C. angulata energy metabolism to mediate differential heat tolerance.
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PMC11412721
A minimum of 10 backcrosses with C57Bl/6J mice of both sexes (Charles River Laboratories) were performed before establishing the cohorts of Trp53 and Trp53 littermate mice used in this study.
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PMC9429973
Median time from allo-SCT to relapse was 4.7 months (0.43-88.6).
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PMC11420784
After 1 hour, cells were washed and treated with Roswell Park Memorial Institute (RPMI) 1640 medium containing 100 μg/mL gentamicin for 1 hour to kill all extracellular bacteria.
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PMC11155445
Investigation of the synthesized composites showed that the increase of copper content increased the kinetics of polymerization and DBCs at specific concentrations of the acyl thiourea (163) and CHP.
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PMC11530949
The results of this research propose that modifying the surface of synthetic NPs with specific targeting agents could improve their performance in cancer treatment and detection.
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PMC9784246
M199 and Dulbecco’s Modified Eagle’s Media, kanamycin, dimethyl sulfoxide (DMSO), etoposide, miltefosine, fetal bovine serum, and MTT were obtained from Nacalai Tesque in Kyoto, Japan.
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PMC11345828
We next evaluated compound 26 in an Mcl-1 sensitive non-small cell lung cancer cell line A427 both as a single agent and in combination with a standard of care chemotherapeutic agent, docetaxel (Figure 5).
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PMC11267036
As shown in Fig. 2A, RIG-I mRNA expressionin tumor plasma was notably lower than those in normal plasma (p < 0.05).
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PMC9118379
SG-D).
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PMC9509578
Also, a dysfunctional TP53 gene results in attenuated apoptosis in multidrug-resistant cancer cells .
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PMC11453018
The following day, iP300w or its stereoisomers were administered as part of the therapeutic regimen.
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PMC11171319
Similar to HPV disease pathophysiology , although even healthy individuals might be at risk of HCMV-induced oncogenesis, immunocompromised individuals could develop persistent, treatment-refractory, and progressive HCMV-linked cancers.
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PMC11286266
Samples were harvested and lysed in the presence of 20 mM N-ethylmaleimide (NEM), immunoprecipitated (IP) using GFP-Trap Agarose (ChromoTek) and analysed by immunoblot (IB) using an anti-FLAG M2 antibody to detect ATF6α.
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PMC11552389
Five fields of view were analyzed per section.
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PMC11650848
Umbilical cord blood samples were collected at delivery.
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PMC11394730
Beyond this business standpoint, anthocyanins have also been suggested as therapeutic agents for the prevention of cancer, heart disease, and some metabolic conditions like type 2 diabetes and obesity .
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PMC11703896
The positive control crizotinib (-8.6 Kcal/mol) exhibited a higher docking affinity.
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PMC11095939
Right: representative peptides of Nedd4 identified by mass spectrometry. (
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PMC7022782
The ICG concentration was chosen on the basis of the results obtained in the experiment reported above.
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PMC11727907
Moreover, photoreceptors and the retinal pigment epithelium (RPE) are engaged in crosstalk, and mutually influence each other .
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PMC11541409
The result from this reference also correlates with in vitro data.
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PMC10154097
U6 and GAPDH served as control of the nucleus and cytoplasm, respectively.
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PMC11291490
The ducks were sacrificed at 7 dpi.
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PMC11622247
The combined photon absorption results in exceptionally bright FIT probes.
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PMC10538569
Two additional donors, Donor 2 (blue) and Donor 3 (purple), were evaluated for GPI-scFv X5 modified CD8 T cell mediated trans protection of CD4 T cells.
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PMC11092382
They can be obtained from various species ranging from mosses to flowering plants, animals, or microorganisms and have offered unique chemical templates or novel scaffolds for drug discovery (Atanasov et al., 2021).
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PMC11279598
Ovariectomized nude mice with estradiol supplements were implanted with ER-positive MCF-7 tumor cells subcutaneously in the flanks and treated with MH or control dextrose administered by oral gavage after tumors achieved a size of 50–75 cm.
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PMC11476004
Pereira et al. tested DNA integrity in the sperm of dogs, using the comet test to determine the level of oxidative damage.
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PMC11674146
While trying to link CLP36/PDLIM1 with malignancies, it should be noticed that CLP36 is involved in the apoptosis and proliferation of chronic myelogenous leukemia cells (Li, Luo & Song, 2020).
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PMC9429973
Summary/Conclusion: No hypercoagulable state elicited by COVID-19 vaccination was observed, contrarily we detected an overall persistent reduction of coagulation activation over time.
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PMC10812665
A high correlation (R = 0.8) was observed (Figure 7C).
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PMC8336407
03< 0.001E2.02.44 ± 0.
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PMC9429973
In North America patients will be enrolled in the PedAL Screening Protocol - APAL2020SC.
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PMC11707577
A431 cells, seeded in 96 well plates (Sarsted) were incubated for 45 min in the presence of 3D‐TNP, M13EGFR(TNP), and HSA‐TM at different concentrations.
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PMC9429973
The PDC and rate of non-adherence were analyzed by means of descriptive statistics.
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PMC9429973
Only diabetes as a comorbidity correlated with severity grade in SCD (p=0.01) and hypertension in THAL (p=0.009).
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PMC10955424
The human XL cytokine array kit (#ARY022B, R&D Systems, Minneapolis, Minnesota, USA) was used to detect relative levels of 105 different human cytokines, chemokines, growth factors and adipokines.
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PMC8526701
Detection of the bands was performed using ECL solution.
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PMC11684297
This indicated that the synthesized ZnO-NFs could elicit the cancer cell-killing effect at a very low concentration.
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PMC9559528
At a one-week follow-up, only post-inflammatory hyperpigmented patches remained, but the crusts and erosions had resolved (Figure 2).
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PMC11502066
The activation of cognate receptors, ARs α1, α2, β1, β2 and β3, by these neurotransmitters can promote the process of malignant progression and metastasis, inducing cell migration, invasion, angiogenesis, extravasation, and colonization .
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PMC9429973
Some physicians advocated more intensified regimens such as R-DA-EPOCH, R-HYPERCVAD, VACOP-B/MACOP-B or the BFM ALL protocol.
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PMC11583010
Sections were arranged on the slides and fixed in acetone at −20°C for 10 minutes.
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PMC11323699
The table (lower part of panel) presents fluorescent quantification on plasma collected at T0.
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PMC9429973
Mavorixafor alone reduced IgM secretion, blocked CXCL12-induced cell migration and Ca mobilization and disrupted the adhesion of WM cells to established BMSCs.
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PMC9429973
Longer follow-up and larger multicenter studies are needed to confirm the efficacy of this regimen.
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PMC11453018
Moreover, RT-qPCR analysis at 24 h post-iP300w treatment revealed a significant downregulation of EWS::FLI1 target genes, notably NKX2.2, NR0B1 and C-MYC (Fig. 2E, Supplementary Fig. 1C).
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PMC10589262
Cancer cells alleviate ER stress by initiating the UPR system that usually leads to mutant protein degradation by ERQC.
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PMC10170482
The open-source software Icy (https://icy.bioimageanalysis.org) was used for 3D reconstruction and 4D visualization.
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PMC9429973
All had molecular confirmation of disease.
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PMC6222635
The expression level of the apoptosis-related genes NF-κB, Bcl-2, p38, ERK, and JNK was determined by Q-PCR equipment (CFX96 Touch™ Real-Time PCR Detection System, Bio-rad Laboratories, Inc., Hercules, CA, USA).
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PMC10849234
After confirming differentiation of the cells (Fig 1A and 1B), we began comparing degranulation conditions for differentiated NLCs.
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PMC11064533
E. coli strain 4972 was present within a clade corresponding to phylogroup A (14) containing strains isolated from human fecal samples with diverse lifestyles, including commensal, enteroinvasive E. coli (EIEC), EAEC, enterohemorrhagic E. coli (EHEC), and enterotoxigenic E. coli (ETEC) pathotypes.
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PMC11754291
The LEDs are positioned above the cell culture plates to ensure uniform irradiation.
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PMC11310713
Data are means ± SEM. *
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PMC11723947
It is not only activating signals that regulate T cell activation.
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PMC8389560
Similarly, the expression level of the P2Y12 gene encoding P2Y-purinoreceptors, a key receptor in the signaling of SeNP, increased 3.2 times after incubation with SeNP and 2.6 times against the background of Gap26+SeNPs.
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PMC11766309
Gene mutation and amplification were explored via the cBioPortal database (https://www.cbioportal.org/).
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PMC11534377
DNA methylation, a critical epigenetic mechanism, plays a significant role in regulating gene expression .
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PMC11525293
From the data obtained, we hypothesized that the observed protection might be due to the diminished viral re-entry due to ACE2 downmodulation upon Thal treatment as a consequence of ΔNp63α degradation.
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PMC11678448
The sequencing data, detailed in Supplementary Table S3, comprised six samples (three experimental groups and three control groups) and generated 242 million raw reads.
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PMC9429973
Reads were aligned to the human reference genome (GRCh37, Ensembl annotation, Isaac aligner) and variants were called using Strelka Somatic Variant Caller v2.4.7.
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PMC10813895
However, genetically high-risk women show on average higher levels of progesterone than average-risk women , and ELF5 expression nevertheless decreases at a rate that is 10 to 40 times faster than average risk women .
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PMC9429973
Two reviewers appraised the quality of trials and extracted data.
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PMC11806106
The following function was used:[12pt] $$}=(}}_-}})* (-}* })+}}$$=(Y0−NS)*exp(−K*X)+NSwith Y0 being the activation at time zero (in units of the Y axis), NS the nonspecific binding at infinite times (in units of the Y axis) and K the rate constant in inverse units of the X axis.
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PMC11635519
Genetic construction that encodes the fusion protein used to display library peptides on the cell surface. (
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PMC11622247
The signaling mechanism is based on FRET between brightly emitting donor dyes and a fluorescent base surrogate, such as quinoline blue (QB) or thiazole orange (TO).
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PMC9681981
Primary genomic evaluation of studied strain Initially, provided standard strain of C. perfringens type D by Ahvaz Branch of RVSRI, was evaluated for the presence of α- and ε-toxin genes and absence of β-toxin gene by conventional PCR.
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PMC7504302
The study by Goto et al. defined that a number of genes silenced in MPM samples were enriched for the repressive histone H3 lysine methylation (H3K27me3) mark , which is a downstream target of PRC2 (the polycomb repressive complex 2).
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PMC11656657
4In vivo experiments of NSG mice bearing GD2 + sarcoma cells (RD, 143B or U-2OS) treated with NT or CAR.GD2 T-cells.
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PMC11700340
Multiple studies have provided evidence in acceptance of this idea.
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PMC11047729
They are involved in the creation of cell membranes, the regulation of blood pressure, and inflammatory responses.
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PMC9960565
Aquated cisplatin (0.10 g 0.39 mmol, 32.5 eq. mol) was dispersed in 90 mL of UPW.
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PMC9024365
Coverslips were then transferred to a recovery buffer (aCSF w/Mg; no drugs) for 20 min at 37C.
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PMC11637276
p38 MAPK is a family of 4 serine/threonine-specific protein kinases: p38α or MAPK14, p38β or MAPK11, p38γ or MAPK12, and p38δ or MAPK13 .
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PMC11701801
To identify the consequences of SS18–SSX protein expression, we analyzed ChIP-seq data obtained after SS18–SSX fusion–specific (shSSX) knockdown.
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PMC7570809
Angiogenesis is required for invasive tumor growth and metastasis and constitutes a key process in the control of cancer progression, thus elucidating its tight correlation with tumor cell invasion and migration.
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PMC11742231
Despite their utility, these approaches often struggle to capture the full complexity of molecular interactions, leading to limited prediction accuracy.
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PMC11507371
NF-κB exhibits a broad spectrum of signal-, context-, and cell-type-specific effects since a number of stimuli activate different NF-κB subunits, resulting in diverse cellular responses.
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PMC9429973
In this single-arm, single center, dose-finding, investigator initiated trial (IIT) (ChiCTR2100051028), its safety and efficacy in relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) patients were explored.
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PMC11569208
On the other hand, phosphatases are much harder to target with specificity given that (1) a highly conserved active site or phosphatase binding pocket makes specificity difficult, and (2) the positively charged active site challenges cell membrane permeability.
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