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OTAR3088
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BioData-CellLine_annotated

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PMC11551844
The UV spectra of AuNPs-JDH, AuNPs-JDE and AuNPs-JC-2 showed a shift in the wavelength in comparison with the control (Fig. 3A).
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PMC9429973
The characteristic is presented in Table.
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PMC10158546
PrP amyloid seeding activity in ReN cell lysates was measured via RT-QuIC at each time point post-inoculation with the four prion isolates. (
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PMC11359735
Figure 2Metabolic labeling of P. berghei sporozoites with [H]-palmitic acid and [H]-ethanolamine.
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PMC6163708
All other cell lines were purchased also from ATCC: G-401 and A-204 (rhabdoid tumors), U-2 OS and Saos-2 (osteosarcomas), HeLa S3 and C33A (cervical carcinomas), 293 (renal carcinoma), HT-1080 (connective tissue fibrosarcoma), SW-13 (adrenal gland carcinoma), T98G (glioblastoma), IMR90 and WI-38 (normal human fibroblasts), Jurkat (T-cell leukemia), Hep-G2 (hepatocellular carcinoma), SK-N-SH and SH-N-MC (neuroblastomas), PANC-1, PA-TU-8902, MIA PaCa-2, and BxPC-3 (pancreatic carcinomas).
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PMC11721587
The reaction was terminated by adding 2× SDS loading buffer.
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PMC8864075
To investigate whether TWIST1 played an important role in reTFAE’s effect on the EMT process, we applied the small interfering RNA (siRNA) method to knock down the TWIST1 gene in A549 cells.
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PMC11727062
Furthermore, these extracts activate the expression of key death-related proteins within the cytoplasm of melanoma cells, including p53, caspase-3, caspase-9, cytochrome c, and Bax, which are crucial for the induction of apoptosis.
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PMC8345486
The baseline expression of ac-p53 in the OVCAR-3 cells was at a marginal level of detection (Figure 7C); therefore, the effect of compound 2 was significant (p < 0.01, Figure 7C).
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PMC9473868
RA shows abnormal proliferation, apoptosis and invasion in Fibroblast-like synoviocytes (FLSs).
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PMC11224020
Box plots show the minimum to maximum range (N = 3; n = 100 cells in 4 µm (DMSO), n = 93 cells in 3 µm (DMSO), n = 97 cells in 3 µm (CK666)).
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PMC11469524
Fig 2D shows the best fit and consistency statistics for the transferred networks (transfer) in comparison to the literature-based starting network (literature) and the adjusted literature-based network (adjusted).
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PMC9429973
These characteristics challenge both the initial molecular diagnostics and MRD monitoring in ALs with KMT2A-r.
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PMC10452486
The treatment of IMR-32 cells with retinoic acid (RA) induced the cells to differentiate with morphological changes.
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PMC11082662
Additionally, several studies have demonstrated that ACER2 is associated with the proliferation, apoptosis, DNA damage, and autophagy in various cancer cells (25-28).
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PMC11519077
The seeded cells were rinsed multiple times with PBS before being cultured for 2 days in the new DMEM+FBS medium+Pen/Strep medium.
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PMC11746948
This screening was repeated three times, and the average data were taken.
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PMC11774112
The combination of DTIC and miRNA 34a significantly inhibited the growth of A375 cells.
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PMC11792090
This maybe because lack of HLA molecules can increase the rejection from natural killer (NK) cells (16).
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PMC11394227
For the Western blot analysis of antibodies, the primary antibody was not incubated, and the secondary antibody, HRP-Goat Anti-Human IgG (H + L) (Proteintech), was incubated for 1 h after closure and cleaning with a dilution ratio of 1:10,000.
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PMC9429973
Figure 1) Image: Summary/Conclusion: GADD45A controls the balance between apoptosis and autophagy via the p38 and JNK/MAPK pathways and PPP1R15A participates in growth arrest and apoptosis in response to DNA damage by attenuating the translational elongation of key transcription factors.
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PMC4685341
The cultivation without selective pressure resulted in the lowest non-fucose levels.
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PMC11286266
To extract total RNA, cells were treated with TRIzol Reagent (Invitrogen) for 10 min and then transferred to a new tube.
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PMC10698968
We know that the tumour of origin infiltrated the adjacent bone tissue, and we can speculate that this contact might have influenced the ECM production program of the tumour cells.
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PMC9429973
Hematopoietic stem cell transplantation (HSCT) was performed in only 2 patients.
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PMC9429973
Results: We reported expansion of PD1+CD244+, PD1+CD160+, PD1+CD57- cytotoxic T cell populations from MF patients, together with increased expression of all the IRs assessed on both total CD3+CD8+ T cells and PD1+CD57- T cells fraction.
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PMC11395280
Differences in the internalization of CCR7 ligands have been reported in naïve and activated CD4+ and CD8+ T-cells, dendritic cells, and CCR7 transfected cells .
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PMC9429973
Methods: In dose escalation, cohorts of up to 12 patients each will receive ascending oral doses of HMPL-760.
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PMC9250505
The yellow triangle points to the start of the treatment.
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PMC10093184
We speculate that the slight differences in migration capacities of other COS cells observed between scratch- and cell culture insert-based assay can be attributed to differences in cell plasticity necessary to cross the pores in the insert membrane.
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PMC11723947
e Number of differentially-accessible peaks (DAP) between WT and HP1α-deficient T cells.
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PMC9429973
RedCapp was utilized to organize demographic, clinical, laboratory, therapeutic, and outcome data.
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PMC10850553
Data are shown as mean ± s.e.m.
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PMC11779876
The distinction between TRBC1 and TRBC2, differing by only two amino acids at the accessible epitope, is a remarkable achievement complementing the group’s success in targeting TRBC1.
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PMC6114978
Some reports have addressed the possibility that the Hippo pathway is primarily silenced through promoter hypermethylation [43–45] or ubiquitin mediated degradation , however this has not been investigated in a comprehensive manner.
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PMC9429973
The median progression-free survival (PFS) was 23.6 months (95% CI, 13.4 to 43.2; Figure 1C), and median overall survival (OS) was not reached; at 45 months, 85% of patients were alive (95% CI, 0.72 to 0.92; Figure 1D).
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PMC3888431
Therefore the combined assemblies, with about 4 million sequences were used for the following steps.
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PMC11783017
Afterward, we systematically monitored the biodistribution of the liposomes during the treatment process.
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PMC8873393
B The percentage of RNA sequencing reads mapping to intronic and exonic regions for all samples.
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PMC11448304
We annotate protein pathways based on the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, and identify proteins through BLAST comparison (blastp, evalue ≤ 1e-4), for each sequence, the annotation is based on the top-scoring comparison result.
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PMC3203927
Another study by the same group showed that when the same cells were grown in Matrigel (lrBM) there was up-regulation of cytokines when compared to 2D.
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PMC11769516
Six hours after exposure to mycotoxin, a significant increase in caspase-3 activity was observed.
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PMC9429973
With successive decision trees the data set is split until as many individuals with the same HbF level are grouped.
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PMC11530949
The cellular results also exhibited the high cytotoxicity of Ag-doped CuO NPs on HepG2 cells.
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PMC9429973
54,86% were male and the median age at diagnosis was 73 years old.
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PMC11129910
Metaphase cells that were analyzed by G-banding showed an abnormal complex karyotype (Figure 8(a)).
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PMC8584319
During this period, the decrease in protein synthesis by co-treatment with AZD8055 and refametinib was not significantly different from that observed after treatment with AZD8055 alone, suggesting that down-regulation of ERK1/2 activity enhances AZD8055 function (Figure 4c).
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PMC9429973
Among relapsed patients without curative treatment, only one was vivant (neurological relapse).
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PMC11684269
For instance, butyrate, a specific type of short-chain fatty acid (SCFA), could improve FAO in Treg cells, which in turn enhances its differentiation, thereby attenuating autoimmune response (53).
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PMC7802142
After 3, 6, 12 or 24 h of incubation, DPCs were washed, fixed and immunostained with α-SMA (a marker for DPCs).
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PMC11615828
Scale bar, 2 µm.
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PMC10847511
During cell culture of the pancreatic cancer cell line CAPAN-1 with a BRCA2 mutation, the addition of cisplatin induced the emergence of subclones with a BRCA2 reversion mutation, resulting in resistance to cisplatin and the PARP inhibitor AG-14361.
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PMC11545737
Shigella infection triggers the apoptotic signal of the Tumor protein p53 (TP53) in epithelial cells, but the bacterium can prevent the induction of apoptosis by cleaving the calpain inhibitor calpastatin through the VirA factor.
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PMC11676169
Overall, our findings suggest that BCAT1 regulates DNA repair and that targeting BCAT1 could represent a promising therapeutic option, especially in combination with DNA-damaging agents, in T-ALL patients with NOTCH-1 activating mutations presenting high levels of BCAT1, mostly included in the cortical (CD1a) immunophenotypical subgroup.
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PMC11787381
We have complied with all relevant ethical regulations for animal use.
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PMC11588008
In our study, we found that HUC-MSCs increased GSH levels and decreased GSSG levels in granulosa cells through the expression increase of γ-GCS (Figure 6a).
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PMC11730311
In this study, we applied the peptide drug discovery platform, streaMLine, to study hCGRP-R antagonism of a comprehensive series of lipidated hαCGRP8-37 analogues.
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PMC9429973
Transcripts of the interviews were analysed and barriers and facilitators were identified and categorized according to the frameworks.
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PMC3019555
In contrast, TX treatment did not affect HIF-1α translation in 1A9/PTX10 cells, as >90% of HIF-1α mRNA was associated with translating polysomes in both untreated and treated cells (Fig. 2 B and Table I).
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PMC11335267
The contribution of Alx3 as a regulator of metabolic homeostasis has been associated to date with the pancreatic islet dysfunction observed in adult Alx3-deficient mice, and fittingly, no other readily detectable metabolic defects have been described in these animals.
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PMC11209164
Our findings demonstrate that the TPF treatment leads to a significant downregulation of the above antiviral and pro-inflammatory genes as shown in (Figure 4A).
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PMC11754432
ML351 treatment in 2D keratinocyte cultures reduced oxidation of BODIPY C11 (Fig. S4A) suggesting ML351 can limit lipid peroxidation in keratinocytes.
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PMC9684669
The heated samples were centrifuged at 20,000 × g for 20 min at 4 °C to remove the precipitates from the soluble fractions.
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PMC7823217
Recently, a rational integration of microfluidic systems with extrusion printing was adopted to attain rapid deposition of bioink (Fig. 2-B).
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PMC7724160
Following deglyslylation, the glycan species were purified, fluorescently-labelled, and separated using a UPLC column connected to a fluorescence detector.
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PMC8839885
Platinum intracellular concentration is regulated by the copper transporters CTR1, CTR2, ATP7A, and ATP7B that are essential for uptake and efflux of platinum into cells .
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PMC11394730
The procedures that turn food carbon into FAs are part of lipid synthesis.
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PMC11321678
To this end, the research on heterogeneities among different tumors and within the same tumor subtype is essential.
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PMC11730311
CHO-K1 cells expressing the hCGRP-R were exposed to increasing concentrations of antagonist and a fixed concentration of hαCGRP corresponding to EC90 (24 pM).
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PMC11766309
This investigation is not without its limitations.
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PMC9429973
We recently described a targeting strategy based on the mutually exclusive expression of T cell receptor beta-chain constant domains 1 and 2 (TRBC1 and TRBC2) (Maciocia, PM.
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PMC11286266
The alignment was performed using the MacVector programme. (
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PMC8303372
The encapsulation efficiency was calculated according to the following formula:GA entrapment efficiency = [mg GA entrapped/mg GA initial] × 100 The in vitro release studies were performed by dispersing 3.0 mg of GA-NPs (containing 1.22 mg GA) in (2 mL) of phosphate buffer solutions (PBS, 0.1 M, pH 7.4) under magnetic stirring (300 rpm).
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PMC9429973
SMARCA4 knockdown in AML cell lines resulted in significantly lower proliferation rate in three different AML cell lines compared to controls, whereas SMARCA4 overexpression led to higher proliferation rates.
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PMC10452486
The anti-HC antibodies, which recognize Face-2 and their dimers, minimize spontaneous arthropathies.
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PMC11756514
However, the precise downstream processes after langerin binding are not clear since langerin only has a short cytoplasmic tail and no classical signaling motifs.
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PMC9874064
Here, the influence of USP1 on DNA damage response pathway in patients with liver cancer was first explored by bioinformatics analysis.
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PMC11679033
Overall results of this pilot in vitro study suggest that CIT diminished the beneficial effects of CBD at the cell level.
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PMC7823217
3Bioprinted breast cancer models.
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PMC9429973
Methods: In the double-blind, placebo-controlled phase 3 AGILE study, patients (pts) were randomized 1:1 to IVO 500 mg QD + AZA 75 mg/m SC or IV for 7 days in 28-day cycles, or placebo+AZA.
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PMC11543935
A larger model would enable electrodes with more needles used for larger ablation area.
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PMC11802855
Statistical analyses were performed using R, version 4.3.3 (http://cran.r-project.org).
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PMC10823017
Similar to drug treatment, siRNA treatment, in both the Caki-1 and 786-0 cells caused about a 75% (P<0.001) and a 61% (P<0.001) knockdown of PKC-ι, respectively, triggering the downstream deactivation of Akt1 and ERK1/2.
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PMC11687663
The phytoconstituents B8, B11, B13, B15 and B16 showed the optimal CaCO2 permeability value (higher than −5.15 cm/s), but remaining 12 phytoconstituents showed a value lower than the optimal range (Table 5).
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PMC11588008
Using PD98059, we found the impaction of MSCs on GSH was destroyed.
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PMC2777936
These cells share many features in common with embryonic stem (ES) cells and their induced differentiation mimics critical stages of early embryogenesis .
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PMC5600151
Such construction provides a surface with a high density of primary amines in binding with nucleic acid molecules.
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PMC11699465
TIP cellular component enrichment analysis led us to consider the potentiality of TMEM199 nuclear localization.
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PMC8345486
The analysis of the effects of the compounds on cell viability and the ability to accumulate in cells was performed with special focus on the type of metal ion in the cluster and the position of modification in adenine nucleosides as well as the importance of the presence of a nucleoside in conjunction with a metalla bis(dicarbollide) ion.
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PMC11243198
GANT61, discovered by small-molecule screening in a Gli reporter cell-based assay , was shown to directly block GLI-mediated transcriptional activity .
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PMC9429973
Whether patients with DLBCL, FL or MM share the same trait as patients with CLL remains unknown.
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PMC9429973
There was no clinically significant leukocytosis, anemia, thrombocytopenia, extramedullary involvement including central nervous system.
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PMC8010066
Oue analysis revealed a significant strain-dependent effect of S. aureus on the virulence of P. aeruginosa (P-value The studies by Kim et al. (2015), Radlinski et al. (2017), and Yang et al. (2011) confirmed that the virulence of P. aeruginosa altered by interaction with S. aureus.
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PMC11591030
The contents of antioxidant indicators (SOD, GPx, CAT, T-AOC, MDA, 8-OHdG, PC, and ROS activity or content) in the culture medium, as well as the expression of genes related to the NF-κB and Nrf2 pathways, were measured.
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PMC11545737
Among these processes, pyroptosis plays a crucial role in bacterial infections.
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PMC6889484
Error bars represent SD.
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PMC11321678
We used unsupervised clustering methods and silhouette plots to determine the optimal cluster number.
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PMC11298021
Jurkat cells (T-cell acute lymphoblastic leukemia cell lines) carrying early activating mutations in NOTCH1 was acquired from the Iranian Biological Resource Center in Tehran, Iran.
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PMC9599726
It is of note that non-epithelial (hematopoietic and lymphoid, bone tissue, ovary, soft tissue, etc.)
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PMC11661024
Cervical cancer is the third most frequent form of malignancy among women and the fourth cause of mortality among women worldwide [1–3].
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