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PMC9429973
J. Rojas, H. Jaramillo, F. Avalos, P. Velasco Hematology, Hospital Metropolitano, Quito, Ecuador Background: Convalescent plasma as a therapeutic alternative in COVID-19 could provide passive immunity creating neutralizing antibodies, potentially decreasing viral entry into host cells; however, the exact mechanism of viral elimination in COVID 19 is not yet known and the clinical data are not conclusive.
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PMC11753435
We computed the mean Hamming distance between generated peptides and their source peptides as we varied the value of k. We did this for an ensemble of 100 source 18-nucleotide oligomer peptides, creating 500 generated peptides for each.
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PMC10719213
At effective concentration of cladribine, we did not detect any alterations in mitochondrial protein synthesis or steady-state protein levels (Fig. 2) in either cell line.
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PMC11119602
The TG2 protein sequence (UniProt accession n. P21980) was scanned for potential functional sites using the Eukaryotic Linear Motif (ELM) prediction webserver.
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PMC11472639
indicates a significant difference from post-exercise at p < 0.01.
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PMC9454852
Red (ex = 535, em = 590 nm) and green (ex = 485, em = 535) fluorescence values were acquired, and red/green ratios were calculated to indicate the mitochondrial membrane potential.
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PMC6461034
The activation loop peptide contribution was left unchanged.
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PMC8481254
Cell viability was measured using a CCK8 (Beyotime, Shanghai, China).
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PMC11502066
The stimulation of GPR30 by 17β-estradiol (E2) can regulate cell survival, proliferation, migration, and invasion in estrogen-responsive tumors but is involved also in the development of resistance to conventional antiestrogens like tamoxifen .
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PMC3203927
Because of this, claims of “physiologically more relevant” are readily made for cells cultured on any surface or scaffold that provides loosely defined 3D geometry, either at the nano- or micro- structure levels or their combinations, as long as the resulting cell phenotypes are different between the 2D and 3D geometries.
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PMC11549062
And PTP1B modulates PDGFR‐β signaling via Rab5‐mediated endocytosis.
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PMC11615101
To validate the role of α-Taxilin, primary cells (RAFLS) were treated with different doses of recombinant α-Taxilin, and NF-kB p65 levels were assessed using WB.
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PMC9429973
Levels of plasma iron, transferrin saturation and ferritin are increased in hemochromatosis C282Y homozygous individuals.
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PMC9429973
Both datasets had been processed using Almac’s claraT platform, a software-driven solution which provides a comprehensive overview of tumour profiles using gene expression signatures.
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PMC11627398
Next, the hub gene-miRNAs-lncRNAs network and gene-TFs network were constructed.
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PMC11519077
Therefore, the upregulation of NOD2 expression in CD patients may be a generic reaction to bacterial invasion and a futile attempt to reestablish the damaged epithelial barrier.
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PMC11442172
To address this issue, several next-generation culture platforms have been developed.
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PMC5673060
For instance, the dasatinib-resistant cells harboured additional gains on chromosome 17 and losses in chromosome 13 which were not observed in the pazopanib-resistant line .
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PMC3164356
Viral infections can contaminate cell culture processes, thus affecting the quality and yield of recombinant protein production.
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PMC11670407
These observations demonstrate that OTULIN confers cisplatin resistance in vivo.
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PMC5417661
In the later time points, the MI of NOV202 treated OvCar-8 and OvCar-4 cell populations dropped dramatically that was likely due to the short transient M phase arrest and increasing cell death.
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PMC9429973
Progression-free (PFS) and overall survival (OS) was poor in the ‘aplastic’ patients (Fig. 1, 1-yr PFS 24%, 1-yr OS 48%).
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PMC10996034
Subsequently, the cells were blocked with 3% BSA for 30 min (Wuhan Servicebio Technology Co., Ltd.), washed three times with PBS and incubated with the primary antibody (same as aforementioned immunohistochemistry antibodies) overnight.
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PMC8956657
The Epstein‐Barr virus nuclear antigen leader protein (EBNA‐LP) was shown to bind using a highly similar interaction, in which a P0 Arg binds at the canonical P2 site (Supplementary Fig. 3).
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PMC11344246
Error bars represent range of the averages of n = 3–4 wells from n = 2 biological replicates.
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PMC11075223
It protected the brain from I/R injury in rats by reducing the levels of oxidative stress, inflammatory factors and activating the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) signal pathway .
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PMC10094712
Ligation was carried out at 4 °C for 16 h or 3 h at room temperature, and then the ligation mixture was used to transform the bacterial strain Top 10.
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PMC11621493
All members of the PLA2G4 family, except PLA2G4C, possess a Ca-binding C2-domain, which can mediate the targeting of proteins to cell membranes or lipid substrates.
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PMC11064533
For complementation of deletion mutants, only mutants exhibiting altered adhesion in initial experiments, i.e., flgH, ffp, yggT, spnT, and pilV, were cloned from the wild-type strain 4972 into expression vector pBAD33 as described previously (36).
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PMC11413393
Follow up dose–response experiments comparing the inhibition of type I PRMTs by MS023 to the activity of a chemically similar but inactive compound, MS094, demonstrated high specificity and potency for type I PRMT inhibition (Fig. 1b and Supplementary Fig. 2a–f).
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PMC11792888
For the cell cycle analysis, cells were fixed in ice-cold methanol (100%) for 1 h at -20°C.
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PMC11443022
In this patient, the observed phenotype was male, with a chromosomal examination of peripheral blood indicating a ratio of 25% 45,X and 75% 46,XY.
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PMC11400680
And, the last component, the mask decoder, maps the image and prompt embeddings to the output segmentation masks.
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PMC8903741
Schematic representation of the production of CHO cell-based anti-hMMP9 monoclonal antibody.
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PMC9436459
8Structures of dehydroprenyldihydroflavone type MDAAs (Type E) Structures of dehydroprenyldihydroflavone type MDAAs (Type E) Among the reported type E-I MDAAs, all compounds having the diene moiety on ring B (all at C-3′) are trans–trans configuration.
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PMC11040965
Band intensities were normalized to β-actin and then to values for untransfected cells (dotted line).
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PMC11638288
In conclusion, in many tumors, the expression levels of NKp46 are typically closely associated with PFS and overall survival OS of patients, providing novel therapeutic targets for various cancers (Fig. 4 and Table 2).Fig.
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PMC11612508
Therefore, the present work uses graphene oxide (GO) to control the aggregation of magnetic NPs.
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PMC10196713
AmpliSeq libraries were created using the Ion AmpliSeq Transcriptome Human Gene Expression Kit (Thermo Fisher Scientific, Inc.), which was designed by amplifying over 20,000 human genes simultaneously in a single primer pool.
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PMC6835428
In the works described where the IP route was chosen (Table 5, Table 6 and Table 7), particle size was 100–395 nm, and thus not optimal for long peritoneum persistence.
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PMC11761919
The procedure is shown in Fig. S3.
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PMC9429973
Diagnosis was based according to WHO classification criteria (2016).
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PMC9429973
Hematological AEs °III/IV occurred in 6 and 2 pts during V1 and V2, tumor lysis syndromes °III in 2 and 3 pts and infections °III/IV in 2 each.
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PMC11714165
Subsequently, we examined the internalization mechanism of NBD‐F (Figure 2H).
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PMC10988555
As observed in Table 1, all the evaluated complexes are slightly selective for cancer cells over fibroblasts, with selectivity indexes ranging from 5.0 to 21.
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PMC10777969
They result from the Michael addition of the 1,3,4-thiadiazole and 2-thiazoline moieties to levoglucosenone.
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PMC11678130
The in ovo irritation assay was conducted on fertilized chicken eggs (Gallus gallus domesticus) by following the method described in a previous publication .
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PMC5673955
Decreased telomerase activity and the length of telomeres in Jurkat and CD4 cells during cultivation with RrA. TRAP gel electrophoresis for (A) Jurkat and (B) CD4 cells. (
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PMC9581083
Wind, cold, and heat are three common pathogens that can enter the human body from the outside.
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PMC9429973
Aims: The main objective of this study is to identify patients with idiopathic splenomegaly or splenectomy as well as to promote awareness and knowledge of ASMD and GD and their diagnosis algorithm through a national medical education program.
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PMC7185206
Combined ADAM10/ADAM17/PD-L1 immunohistochemistry and serum sPD-L1 may thus better select patients for PD-(L)1 inhibitor therapy in future studies.
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PMC11767793
The Au-PEI@NIST showed exceptional colloidal stability over the entire pH range (in 50 mmol/L HCl (pH 1.2) and 50 mmol/L NaOH (pH 12)) for at least 24 h (Figure S5a–c), while the Au-PEG-COOH@NIST (Figure S5d–f) was destabilized in extremely acidic or basic solutions.
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PMC11206251
The levels of TNF-α, IL-1β, and IL-6 in the cell supernatant were detected by an ELISA kit (Elabscience, Wuhan, China).
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PMC10033453
With an in vitro infection MOI of 10, the canine sarcoma line OSCA-71 exhibited the highest viability 72 hpi with a mean viability of 15% by MTS assay.
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PMC11194678
Representative immunofluorescence images showing the distribution of TFEB in WT (STHdh), HD (STHdh), STHdh-STAU1-KD, and DOX-induced STHdh-STAU1-KD/GFP-STAU1 or GFP-STAU1 5KE cells.
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PMC11347429
Functional analysis using GO term enrichment for the down-regulated DEGs from the contrast of infected versus healthy controls.
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PMC10654497
Consensus clustering was used to categorize the SFRGs into two subgroups based on their expression.
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PMC7823217
Hence, the “one‐size‐fits‐all” treatment approach can have limited effectiveness, identifying a clinical need for more personalized/precision treatment regimens specific to an individual or a subset of patients.
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PMC11269933
Additionally, the ERK inhibitor SCH772984 (HY- 50846; MCE, USA) in DMSO was prediluted with complete media and then added to the cells to reach a final concentration of 50, 100, 200 and 300 nM for 8 hours to inhibit the CgERK activity.
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PMC11742231
This allows MGATAF to capture the cross-correlation between the drug and cancer cell line representations and provide an efficient final representation for predicting the IC50 value.
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PMC10809689
GDH mRNA expression changes in HL-60 cells showed a significant difference between the PMA + Gal-9 group and the control group at 24 and 48 h (p = 0.02) and the most significant difference was achieved at 72 h (p = 0.0001) (b.).
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PMC11317131
To exclude the influence of incomplete transfection efficiency, top evolved variants were assayed in HEK293T cells and sorted for DsRed expression.
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PMC8922418
Once the latent provirus is reactivated by stimuli, new viruses can be produced to infect adjacent cells, and new latent reservoirs can be established (Xiao et al., 2019b).
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PMC9429973
Results: BCL11A (rs4671393) SNP showed higher hemoglobin and HbF levels when induced with HU, with significantly higher increment in HbF level post HU therapy as well as a milder clinical phenotype in our Sβ patients’ group.
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PMC10198699
Accordingly, although the research institution would be in possession of the tissue sample, the donation agreement would be unlawful and hence void, and ownership of the sample would not transfer to the research institution.
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PMC11143482
Biopsy were carried out to collect the primary and metastatic tumours and further preserved in 10% formalin for histological study.
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PMC11365427
Phenylalanine and tyrosine standards were diluted to a series of gradient concentrations with a 50% methanol aqueous solution.
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PMC8873393
DNA profiles of MRC5_VA cells were analyzed by FACS at the indicated time after release from G1/S phase.
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PMC10957991
Besides affecting lineage-specific differentiation of the mammary epithelial cells, we found that TRPV4 was important in the maintenance of normal cell–cell junctions (Figs. 3, S5).
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PMC3035438
Isolated clones (1–15) were grown for 1 week after selection.
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PMC9429973
Image: Summary/Conclusion: Safety and tolerability of sabatolimab + AZA + VEN were comparable at 2 dose levels (400 and 800 mg) of sabatolimab and were overall comparable to the reported safety profile of VEN + AZA doublet therapy.
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PMC11471157
Organization of cell spheroids by HaCaT cells on Day 3.
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PMC11519583
Control and Ror2 cKO mice were injected with either cardiotoxin (Ctx) or glycerol in the TA muscles after intermittent intraperitoneal injection of tamoxifen as indicated.
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PMC8875242
Atazanavir (20 µM), darunavir (50 µM), etravirine (20 µM), lopinavir (5 µM), and ritonavir (20 µM) and DAA asunaprevir (20 µM), elbasvir (5 µM), grazoprevir (20 µM), and ledipasvir (50 µM) also significantly inhibited [H]-digoxin, albeit to a lesser extent, giving rPapp values of 2.75 to 5.88.
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PMC9429973
Median follow-up time was 5 years.
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PMC9429973
These data suggest possible biological vulnerabilities that could be leveraged to overcome resistance to venetoclax.
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PMC11291490
CD40L is prominently expressed on activated antigen presentation cells (APCs), CD4 T cells, and CD8 T cells, emphasizing the inseparable connection between cellular immune responses and CD40L signaling.
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PMC4485648
All of these pathways were individually associated with SFN in earlier studies, but here we detected they simultaneous modulation, in agreement with the known pleiotropic anticancer activity of SFN.
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PMC9429973
Risk stratification done as per revised IPSET (International Prognostic Scoring for thrombosis in Essential Thrombocythemia) score.
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PMC9429973
PBMCs were cultured with or without T cells (in a specific CLL:T cell ratio to mimic the LN composition), or PBMCs were co-cultured with primary lymph node fibroblasts.
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PMC11441402
This is most likely due to loss of cells during the cell fixation step for the SRB assay, and the centrifugation and media removal step for the MTT assay.
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PMC5417661
Paclitaxel and vincristine were used as controls with known high tubulin affinity.
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PMC9429973
The median overall survival for all patients was 3 months (1-38 months).
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PMC11566417
Biologics are produced in microorganisms or mammalian cells, as opposed to being generated by chemical manufacturing processes .
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PMC9541067
In this article, the author would like to correct the duplication in Figs. 4 and 6 as mentioned below.
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PMC11723947
In line with our initial working hypothesis, we showed that HP1α is critically involved in Treg-mediated Th cell suppression through a process implicating heterochromatin-dependent silencing of Th1 and Th17 genes.
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PMC5916734
Factor IX protein secreted by the 3B12-86 cell line was purified by three consecutive chromatography rounds to a specific activity of up to 230 IU/mg, with the overall yield > 30%.
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PMC11320834
Alternative treatments, including combination therapy, represent the most promising strategies seeking to improve oncological outcomes and quality of life for patients with these aggressive diseases.
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PMC7961460
The tight interaction between cancer cells and their microenvironment at the biochemical level is an emerging area of research.
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PMC9429973
MRD was defined as variant allele frequency (VAF) ≥2% for ASXL1 & ≥0.05% for all other analyzed mut.
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PMC11281366
As shown in Figure 7C, expression levels of miRNA-26 were downregulated in cells infected with the different mutant HIV-1 viruses to a comparable extent to those in cells infected with WT HIV-1, suggesting that a reduction in miRNA-26a expression during HIV-1 infection appears to be independent of Vpr, Vpu or/and Nef expression.
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PMC11742431
They can be used to prepare highly sensitive diagnostic reagents for disease treatment, targeted drug delivery, and so forth.
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PMC11589157
Chromosome numbers; (B) Genomic landscape of the pseudochromosomes, with scales indicating chromosome lengths; The sexual chromosomes X and Y are highlighted in blue and red, respectively; (C) Gene density; (D) Repeat coverage; (E) ncRNA density; (F) GC ratio; (G) GC skew; (H) Synteny relationship between pseudochromosomes.
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PMC9424261
P < 0.01; ***P < 0.001; ****P < 0.0001.
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PMC9429973
In 9 patients alloantibody type could not be determined.
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PMC9776316
Repair of DSB by homologous recombination (HR) and nonhomologous end joining (NHEJ) is frequently associated with platinum resistance in ovarian cancer.
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PMC11746942
p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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PMC11267830
The T-ALL data is from GSE110637 and the normal data is from whole blood in GTEx.
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PMC11155445
Compound (139) and Cu complex produced rod-like nano-objects due to coordination interaction and self-assembly of the complex.
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PMC9429973
Aims: To determine whether online continuing medical education (CME) could improve the knowledge, competence and confidence of clinicians regarding clinical aspects of BCMA-directed therapies.
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