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OTAR3088
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BioData-CellLine_annotated

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PMC11532793
Hence, we expected to observe improvements in regard to statistical power and computing time in this analysis of the human adenocarcinoma cell lines data with edgeR-v4 and Gibbs sampling.
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PMC11407042
Set up at least triplicate wells treated with 10× Lysis Solution (provided by the Promega CytoTox 96 Non-Radioactive Cytotoxicity Assay Kit) to generate a maximum LDH release as a positive control.
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PMC11700340
The cells were cultured in RPMI-1640 medium (Sigma Chemicals, England) supplemented with 10% fetal calf serum (FBS) and 100 U/mL penicillin-streptomycin (100 μg/mL streptomycin) .
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PMC11429241
no. 11875093), supplemented with 10% fetal bovine serum (FBS) (Gibco™, cat.
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PMC9096373
Protein expressions of Ki-67, γ-H2AX and apoptosis (×400, red arrows, claybank or brown in the nucleus) among groups.
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PMC11727062
It has been reported that HHT enhances the sensitivity of A375R to vemurafenib in BRAF-mutant melanoma cells that have become resistant, specifically the A375R cells.
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PMC9622879
Figure 12Trade-off between benefits of homes in community with our proposed CEMS under different values of .
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PMC11612508
Biodegradable and synthetic polymeric microspheres are medication delivery systems for malignancies such as colon and GB.
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PMC11794847
Next, we found that HVEM knockdown had no influence on the mRNA expression level of FOXA2 (Fig. 8I).
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PMC10092581
With the Se(IMes)‐ and Se(IPr)‐based Au(I) complexes, complete displacement was observed after 24 h, and the new compounds, [Au(H2O)]Cl, appeared to be stable even after 9 days (Figures S9 and S11).
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PMC11742670
All results are presented in the next section.
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PMC10158546
Sanger sequencing was used to confirm the successful insertion of each PrP sequence into pCDH813A.
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PMC11747885
The compounds were further assessed for cytotoxicity in HEK293 cells.
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PMC11727145
The tissues were incubated overnight, washed with 1× PBS, and stored at 4 °C in 70% ethanol until paraffin embedding.
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PMC10899471
Western blot was performed as we described (24).
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PMC11489351
In summary, our RNA-Seq analyses show that normal mammary epithelial cells exhibit pH-dependent transcription of Notch1 pathway members involved in the cell cycle, metabolism, apoptosis, and proteostasis.
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PMC9429973
Three pts were initially MRD+ but turned negative, all of which had chronic GVHD (cGVHD).
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PMC11143482
This model will also help to address other issues in cancer therapy, e.g., in the gene therapy field which are still in their infancy to be translated to clinical setting.
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PMC11224020
Sample groups under different confinement conditions are represented by different forms.
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PMC11656657
Data of TGCA and GTEX datasets showed expression level of B4GALNT1 in both normal tissues (green) and tumor patients with solid tumours (red).
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PMC11489275
According to two different lymphocyte grouping methods in our study, the 1-month mortality was also significantly higher in the severe lymphopenia patients than in the mild lymphopenia and normal patients.
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PMC11126803
A, the qRT-PCR was performed to detect the expression of LncRNA-SERB in different cell lines.
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PMC9577200
Each reaction was carried out three times.
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PMC11599565
These proteins have been widely reported to be highly fusogenic in addition to their elucidated involvement in immune escape, which is mediated by the immunosuppressive domain (ISD).
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PMC10898159
For example, miRNA sponges is a kind of artificial transcripts that contains multiple miRNA binding sites to trap and sequester it .
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PMC11509278
All the experiments were performed in triplicate except for untargeted metabolomic effects of propolis on the proliferation of A431 cells, and the results are expressed as the means ± standard errors.
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PMC11413393
This assay was performed in RCC243 cells under neutral conditions to specifically quantify the removal of DSBs.
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PMC10926885
T24 cells were first lysed using mild cell lysate under nondenaturing conditions, followed by addition of agarose beads conjugated to the relevant antibody to the cell lysate and incubation.
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PMC11473750
The cell pellet was resuspended in 200 µl RIPA buffer containing protease inhibitor (Sigma-Aldrich, NSW, Australia) and centrifuged at 13,000 rpm at 4 °C for 10 min.
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PMC11779993
They contribute to the immunological and inflammatory process, migrate, and proliferate in association with wound closure mechanism via re-epithelialization, and tissue maturation.
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PMC9429973
MRD negativity was confirmed in 50% (5/10) of CRc cases.
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PMC11756907
Data were analyzed with GraphPad Prism Software version 8.0.1 using bidirectional ANOVA with Tukey’s multiple comparison tests; **p < 0.01, ***p < 0.001, ****p < 0.0001 versus control.
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PMC11443022
While the pregnancy is progressing well, fetal sex determination has not yet been performed in the early stages.
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PMC11592837
Especially in dividing cells, these events are of major importance for tumor suppression and are evolutionary highly conserved, which renders γH2AX as a critical mediator of genomic integrity, cell cycle checkpoints and cell death .
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PMC11095939
In the Mecp2 floxed allele, Mecp2 exons 2 and 3 were flanked with loxp sites.
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PMC10094712
Preliminarily, total RNA was isolated from human embryonic kidney (HEK 293) cell line and used in a reverse transcription reaction.
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PMC9429973
One of the indicators reflecting the functioning of donor hematopoietic tissue is posttransplant chimerism.
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PMC9429973
Median durations of post-remission Gr ≥3 neutropenia and FN in VIALE-C were 15 d and 6 d (Ven+LDAC+G-CSF), and 12.5 d and 29 d (Ven+LDAC+non-G-CSF).
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PMC6461034
The INKA analysis pipeline is available as a web service at http://www.inkascore.org, where the latest updated version is maintained and can be downloaded, while the current code is provided here as a zip file (Code EV1).
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PMC11377827
n = 5 biologically independent samples, mean ± sd. ****
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PMC10874773
jiadifengpi(Kubo et al., 2009)57(2S)-Hydroxy-3,4-dehydroneomajucinNeuroprotectionI. lanceolatumMehta, Shinde, & Kumaran, 201258Dehydro-neomajucinI. verum Hook.f.
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PMC8526701
with 5 × 10 WT or PUMA-KO GIST-882 cells.
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PMC11392912
We, therefore, focused our research work on validating, and quantitating the presence of Clo-miR-14 in the human plasma samples, checked its thermal stability at 100°C followed by in vitro studies using SW982 cells, rheumatoid arthritis fibroblast-like synovial cells (RAFLS).
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PMC10170482
Emerging evidence suggests that such platforms show improved capabilities of inducing in-vivo-like cell fates for distinct physiological and pathophysiological process research.
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PMC11650848
Confirmation that some transcripts began at exon 2 in that tissue was obtained from a Shashimi plot (Fig. 4E): these correspond with the original RefSeq transcript extending from exons 2–5.
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PMC7642379
As four out of the 38 differentially expressed genes (LOX, SMAD7, ID1 & TXNIP) have previously been shown to have a role in the epithelial to mesenchymal transition (EMT) pathway, we evaluated the role of this pathway in the transition from adherent to suspension cell growth of these HEK293 cell lines.
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PMC11802855
J The mm03 subset exhibited a strong correlation with the “B cell proliferation” and “osteoclast signaling” pathways.
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PMC11361748
Transient factors present 24 h but not 48 h after a priming event may be required for TAR to develop in full.
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PMC8839885
Moreover, levels of some ABC transporters such as ABCC1 and ABCG2 were reported to be upregulated by platinum compounds , thus we also monitored levels of ABCC1, ABCB1, and ABCG2.
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PMC9910796
After gradient fractionation, aliquots were analyzed by Western immunoblotting with an anti-p72 antibody to identify the virus-containing fractions, which were pooled and stored at—70°C until use.
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PMC11756514
In the host, another interplay exists between different PRRs.
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PMC11286266
Two-dimensional contour plots of BiP::sfGFP and XBP1s::mCherry signals in XC45-6S obtained after each sort of enrichment (R1: round 1; R2: round 2) in the screen designed to identify ATF6α activators.
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PMC11792888
Cancer cell cycle and cell death results for IC50 doses of scorpion venom alone, etoposide alone, and combined venom/etoposide were determined through flow cytometry as described above.
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PMC6643347
Studying the reproducibility of HIV-infection inhibition by SBF-HS Comparative efficiency assessment of six batches of SBF-HS in an experimental HIV infection CEM SS/HIV- 1-Bru Since stability is an important factor contributing to drug efficacy, we further studied whether the activity of SBF-HS differs between different batches of the preparation.
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PMC8143558
Mangifera indica L. and Kampferia galanga L. were categorized under the Data deficient (DD) category because, according to the IUCN, the information available on these plants is inadequate for direct or indirect determination of whether the species are at risk of extinction.
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PMC11786767
Within 15 min of washing away nocodazole, more than 30% of the control cells progressed from prometaphase into metaphase.
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PMC9429973
Five pts (50%) experienced very rapid disease progression as indicated by a median of 46.2% increase of tumor burden from screening to Cycle 1 Day 1.
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PMC7757104
Briefly, ACRP, OVCar-8 Dox, A2780 OPNc cells or A2780 cells transfected with the pCR3.1 empty vector were seeded in 96-well plates (1×10 cells/well).
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PMC11742290
LGR5 overexpression promoted the formation and proliferation of CRC spheroids .
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PMC11697703
ANOVA-Tukey, p values are presented as follows; ∗p < 0.05, ∗∗p < 0.01.
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PMC11640419
All synthesized compounds have been observed to exhibit higher levels of cytotoxicity than the original oleanolic acid.
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PMC11672881
A live/dead analysis of the A375 MCTSs was performed after 24 h of treatment with 25 µM CU, 10 µM TQ, and their combination, using dual-fluorescence staining with Calcein-AM and PI dyes (Figure 4A).
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PMC5839394
Information on reactivity of AgNPs and the release of Ag(I) species at the AgNPs-EPS/water interface was obtained by combining SECM and voltammetric experiments .
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PMC11730305
Finally, the product (Co3O4@Glu-Ellagic acid) was collected separated by centrifugation at 6000 rpm, rinsed by ethanol, and freeze-dried for 24 h. Fig. 1Schematic representation of Co3O4 nanoparticles binding to Carbon and Ellagic acid.
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PMC11743975
COS-7 cells were transfected with both Tom20-CIBN-GFP and mCherry-CRY2clust (Opto-MitoA).
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PMC11696576
For comparison purposes, previously published data for the inhibitor GK470 are included.
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PMC11409031
The expression heatmap of genes with simulated time values shows that genes with similar expression trends converge to form different clusters.
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PMC8170755
On the other hand, the expression of metastatic tumor indicators, CD44v6, MMP-2, and MMP-9 decreased in A549 cells exposed to VPA.
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PMC11474209
At this level, the potential health risk to humans is considered moderate .
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PMC10823017
A western blot analysis revealed that the combination drug treatment induced the downregulation of phospho-vimentin and vimentin, which coincided with the elevated expression of E-cadherin in the Caki-1 cell line.
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PMC10999934
CCK-8 assays were performed to determine the survival rates of A2780 and A2780/siFBXO2 cells after treatment with cisplatin for 48 h. (C) CCK-8 assays were performed to determine the survival rates of SKOV3 and SKOV3/siFBXO2 cells after treatment with cisplatin for 48 h.Fig. 8 Western Blot experiment. (
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PMC10969097
We searched the PubMed, Web of Science and Scopus databases, following the PRISMA guidelines, and registered on PROSPERO.
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PMC10154881
After 9 dpi.,
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PMC11391695
The cDNAs were amplified using a Plus SYBR real-time PCR mixture (BioTeke, Beijing, China) on a Light Cycler 480 instrument (Roche, Germany).
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PMC11679326
By identifying hotspots in the glycosylation landscapes of carcinomas and gliomas, we propose that lectins and lectin-like proteins specific to the tumor surface of carcinomas can be repositioned for selective recognition of gliomas, and after defining their fine carbohydrate specificity through the identification of preferred carbohydrate ligands, it is possible to create precision molecular labeling tools that differentiate glioma cell populations depending on the cell surface glycosylation status for improved diagnostics and the selection of further therapeutic strategies.
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PMC9583612
A detailed study of temporal variations in methane emissions suggests the potential impact of measurement time on emission estimates, where one-time events like liquids unloading preferentially occur during certain periods of the work-day.
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PMC6600253
Traditional cancer therapy attempts to kill cancer cells by inducing extensive DNA damage using high doses of drugs or irradiation, but this kind of treatment causes severe side effects during cancer therapy.
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PMC11704135
The mass spectra (MS) were recorded on GCMS/QP 1000 Ex mass spectrometer at 70 eV (National Research Centre, Dokki Giza, Egypt).
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PMC9693627
The human mitochondrial genome contains 13 protein-coding genes, all of which encode subunits of electron transport chains .
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PMC9429973
Summary/Conclusion: According to our analysis of a large cohort of newly diagnosed MM patients UHR myeloma, was the strongest independent predictor for OS, supervening the prognostic value of R-ISS.
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PMC11775197
They elucidated that PPARβ/δ overexpression in colon epithelial cells significantly enhances colon cancer susceptibility by promoting the expression of pro-tumorigenic genes, including IFITM3 and NRG1 .
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PMC9822769
Based on its structure, which is intermediate between those of 1 and 3 (Table 1), 2 is expected to be rather ineffective as an antiproliferative agent, as its congeners are.
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PMC9429973
Methods: The morphology of ZnO NPs was characterized by transmission electron microscopy (TEM), and the inhibitory and apoptotic effect of ZnO NPs on human MM cells was monitored by a CCK-8 method and an Annexin V-FITC/PI assay.
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PMC11513011
The tumor volume change rate was calculated with the tumor volume before drug administration in each group set as 1.
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PMC9985266
P < 0.05, **P < 0.01, ***P < 0.001; values are expressed as the mean ± standard deviation (n = 3) IL-27 attenuates TGF-β1-induced fibrosis in MRC-5 cells by activating autophagy through inhibition of the ERK/p38 signaling pathway.
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PMC11714165
Then, Siemens Biograph micro‐CT system (Skyscan 1272, Belgium) was used to scan the excised tibias.
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PMC11476837
Each tested inhibitor, except for ML-385 at 5 μM, significantly increased the population of apoptotic cells.
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PMC11747467
Downregulation of target surface protein expression serve as a resistance mechanism to ADC treatment.
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PMC11449273
When co-expressed, plakoglobin increased the nuclear pool of NPM by 89% and 55% in H1299-p53-175 and -273 cells, respectively (Fig 5B).
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PMC9429973
In acute myeloid leukemia (AML) patients, enhanced ALC recovery after intensive chemotherapy (IC) has been associated with superior OS and leukemia-free survival (LFS).
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PMC11768927
The combination of VSV with other therapeutic modalities is also being explored in other trials.
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PMC11635087
This suggests that the significant decrease in φII can be attributed to the complete disintegration of thylakoid membranes, resulting in a non-functional electron transport chain at 4 days after the co-cultivation.
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PMC11740207
If damaged or stressed, differentiated cells may activate apoptotic pathways, thereby modulating cell growth and preventing the overpopulation of undifferentiated cells.
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PMC10222971
Apoptosis, or programmed cell death, is characterized by numerous morphological and biochemical changes to the cellular architecture.
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PMC11530949
An accelerating voltage of 15 kV, the FEI NOVA NANOSEM 450 Field emission scanning electron microscopy (FESSEM) and the Zeiss EM900 TEM (Transmission Electron Microscope) (Germany) were used to determine the shape and size of NPs.
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PMC7612475
Alternatively, GFP-RNH1 was induced for 24 hours with 1 μg/mL doxycycline, after which, nonbound GFP-RNH1 was extracted with extraction buffer (20 mmol/L Hepes, 20 mmol/L NaCl, 5 mmol/L MgCl2, 1 mmol/L ATP, 0.5% NP40) at 4°C for 2 minutes before fixation with 4% PFA.
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PMC10944868
Structure-Activity Relationship (SAR) analysis is a fundamental approach that investigates the links between the structure of chemical compounds and their observed biological or physicochemical properties.
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PMC9964654
The gold compound TBA[Au(cdc)2] was prepared as tetrabutyl ammonium (TBA) salt according to a previously described method .
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PMC11216402
Plots and P-values were produced using the survminer (https://github.com/kassambara/survminer), ggsurvfit (https://github.com/pharmaverse/ggsurvfit), and survival (https://github.com/therneau/survival) R packages.
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PMC11352666
CERES dependency is a computational method of estimating gene dependency in genome-scale CRISPR-Cas9 essentiality screens that decreases false positive results from copy-number-specific effects due to Cas9-mediated DNA cleavage .
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