Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC10734950
Our results indicate that F8 can downregulate members of the Jak/Stat pathway, suggesting a possible mechanism for induction of cell death.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "results", "indicate", "that", "F8", "can", "downregulate", "members", "of", "the", "Jak/Stat", "pathway", ",", "suggesting", "a", "possible", "mechanism", "for", "induction", "of", "cell", "death", "." ] } ]
PMC7823217
Further, upon treatment with different anti-cancer drugs, such as 5-Fluorouracil, mitomycin and both, 3D models exhibited substantially different HepG2 cell behaviors compared to 2D cell models indicating the closer physiological relevance of bioprinted liver cancer models for in vitro drug screening.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", ",", "upon", "treatment", "with", "different", "anti-cancer", "drugs", ",", "such", "as", "5-Fluorouracil", ",", "mitomycin", "and", "both", ",", "3D", "models", "exhibited", "substantially", "different", "HepG2", "cell", "behaviors", "compared", "to", "2D", "cell", "models", "indicating", "the", "closer", "physiological", "relevance", "of", "bioprinted", "liver", "cancer", "models", "for", "in", "vitro", "drug", "screening", "." ] } ]
PMC10878518
As a single tumor cell is approximately 10 μm in diameter, the number of tumor cells on the surface area of each tissue specimen (2 × 2 × 2 mm) was estimated as 2.4 × 10 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "single", "tumor", "cell", "is", "approximately", "10", "μm", "in", "diameter", ",", "the", "number", "of", "tumor", "cells", "on", "the", "surface", "area", "of", "each", "tissue", "specimen", "(", "2", "×", "2", "×", "2", "mm", ")", "was", "estimated", "as", "2.4", "×", "10", "cells", "." ] } ]
PMC9792775
CCK8 assays demonstrated that LFU alone did not effectively suppressed the proliferation of sarcoma cell line for all groups (p < 0.05).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CCK8", "assays", "demonstrated", "that", "LFU", "alone", "did", "not", "effectively", "suppressed", "the", "proliferation", "of", "sarcoma", "cell", "line", "for", "all", "groups", "(", "p", "<", "0.05", ")", "." ] } ]
PMC9429973
The need for routine typing of certain blood group antigens in addition to ABO and RhD was also evaluated.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "need", "for", "routine", "typing", "of", "certain", "blood", "group", "antigens", "in", "addition", "to", "ABO", "and", "RhD", "was", "also", "evaluated", "." ] } ]
PMC5600151
The use of dendrimer-based systems for antitumor therapy is advantageous, and much remains to be explored and addressed to validate their clinical use with the aim of improvement in the efficacy of treatment and safety for patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use", "of", "dendrimer-based", "systems", "for", "antitumor", "therapy", "is", "advantageous", ",", "and", "much", "remains", "to", "be", "explored", "and", "addressed", "to", "validate", "their", "clinical", "use", "with", "the", "aim", "of", "improvement", "in", "the", "efficacy", "of", "treatment", "and", "safety", "for", "patients", "." ] } ]
PMC9164404
D Pt-DNA adducts of cells treated with cisplatin, CisPt(IV), and Abplatin via ICP-MS.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Pt-DNA", "adducts", "of", "cells", "treated", "with", "cisplatin", ",", "CisPt(IV", ")", ",", "and", "Abplatin", "via", "ICP-MS", "." ] } ]
PMC10940855
These results suggest that EFNB2 does not augment multiple myeloma growth via forward signaling through EPHB4.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", "that", "EFNB2", "does", "not", "augment", "multiple", "myeloma", "growth", "via", "forward", "signaling", "through", "EPHB4", "." ] } ]
PMC8956657
NLS nuclear localization signal, IMPα importin alpha, HA haemagglutinin epitope tag.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NLS", "nuclear", "localization", "signal", ",", "IMPα", "importin", "alpha", ",", "HA", "haemagglutinin", "epitope", "tag", "." ] } ]
PMC9429973
With the Lymphoma Study Association LYSA, we previously published that strong c-Rel DNA-binding activity was mostly found in GCBs and was associated with increased REL mRNA expression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "Lymphoma", "Study", "Association", "LYSA", ",", "we", "previously", "published", "that", "strong", "c-Rel", "DNA-binding", "activity", "was", "mostly", "found", "in", "GCBs", "and", "was", "associated", "with", "increased", "REL", "mRNA", "expression", "." ] } ]
PMC10747160
This was not surprising since the N protein is localized to the interior of the virion; it is, thus, unable to be recognized by cell surface receptors; similarly, the E protein is poorly expressed and incorporated on the surface of viral particles, meaning that it would not provide a drastic increase in glycan epitopes on the surface of the virion .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was", "not", "surprising", "since", "the", "N", "protein", "is", "localized", "to", "the", "interior", "of", "the", "virion", ";", "it", "is", ",", "thus", ",", "unable", "to", "be", "recognized", "by", "cell", "surface", "receptors", ";", "similarly", ",", "the", "E", "protein", "is", "poorly", "expressed", "and", "incorporated", "on", "the", "surface", "of", "viral", "particles", ",", "meaning", "that", "it", "would", "not", "provide", "a", "drastic", "increase", "in", "glycan", "epitopes", "on", "the", "surface", "of", "the", "virion", "." ] } ]
PMC11786156
Regarding pathological aspects (Table 2), the number of non-GCB cases (31 cases, 77.5%) according to the Hans classification was higher than the number of GCB cases (nine cases, 22.5%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regarding", "pathological", "aspects", "(", "Table", "2", ")", ",", "the", "number", "of", "non-GCB", "cases", "(", "31", "cases", ",", "77.5", "%", ")", "according", "to", "the", "Hans", "classification", "was", "higher", "than", "the", "number", "of", "GCB", "cases", "(", "nine", "cases", ",", "22.5", "%", ")", "." ] } ]
PMC9261184
First, stack gas emission rates for methane and CO2 (in kg/h) were determined from the concentration measurements using the standard US EPA Method 19.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", ",", "stack", "gas", "emission", "rates", "for", "methane", "and", "CO2", "(", "in", "kg/h", ")", "were", "determined", "from", "the", "concentration", "measurements", "using", "the", "standard", "US", "EPA", "Method", "19", "." ] } ]
PMC11349530
IL-33, an alarmin cytokine of the IL-1 family (61), is produced by various cells, including cancer cells (62, 63).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IL-33", ",", "an", "alarmin", "cytokine", "of", "the", "IL-1", "family", "(", "61", ")", ",", "is", "produced", "by", "various", "cells", ",", "including", "cancer", "cells", "(", "62", ",", "63", ")", "." ] } ]
PMC9739791
complex then quickly reduces into the Pt(II) oxaliplatin complex.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "complex", "then", "quickly", "reduces", "into", "the", "Pt(II", ")", "oxaliplatin", "complex", "." ] } ]
PMC9429973
Ineffective erythropoiesis is linked to FeO in patients (pts) with hemolytic anemias.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ineffective", "erythropoiesis", "is", "linked", "to", "FeO", "in", "patients", "(", "pts", ")", "with", "hemolytic", "anemias", "." ] } ]
PMC10142392
In contrast, the enzymatic degradation rate using cutinase generally decreased with an increase in PEG content in the case of PEG (PCL)2-b-PEG-b-(PCL)2, indicating that PEG chains slowed down the degradation effect of PCL in copolymers and that PCL was the only one subjected to enzymatic degradation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "the", "enzymatic", "degradation", "rate", "using", "cutinase", "generally", "decreased", "with", "an", "increase", "in", "PEG", "content", "in", "the", "case", "of", "PEG", "(PCL)2-b-PEG-b-(PCL)2", ",", "indicating", "that", "PEG", "chains", "slowed", "down", "the", "degradation", "effect", "of", "PCL", "in", "copolymers", "and", "that", "PCL", "was", "the", "only", "one", "subjected", "to", "enzymatic", "degradation", "." ] } ]
PMC10854447
Found: C, 53.66; H, 3.40; N, 18.59.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Found", ":", "C", ",", "53.66", ";", "H", ",", "3.40", ";", "N", ",", "18.59", "." ] } ]
PMC11026382
The gray dotted line indicates x = y. Color coding is identical to (d).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gray", "dotted", "line", "indicates", "x", "=", "y.", "Color", "coding", "is", "identical", "to", "(", "d", ")", "." ] } ]
PMC11787355
The highlighted overlapped peptide is PTPRZ1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "highlighted", "overlapped", "peptide", "is", "PTPRZ1", "." ] } ]
PMC11549062
Images of the cells within the scratch were captured at 0 h and 12 h using a microscope.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Images", "of", "the", "cells", "within", "the", "scratch", "were", "captured", "at", "0", "h", "and", "12", "h", "using", "a", "microscope", "." ] } ]
PMC11063646
Initially, the nanoemulsions were prepared by solvent evaporation and sonication thereafter (Hernandez-Giottonini et al., 2020) followed by gel preparation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Initially", ",", "the", "nanoemulsions", "were", "prepared", "by", "solvent", "evaporation", "and", "sonication", "thereafter", "(", "Hernandez-Giottonini", "et", "al.", ",", "2020", ")", "followed", "by", "gel", "preparation", "." ] } ]
PMC10968586
Incubation of human amelanotic melanoma cell line C32 with 100 μM, 400 μM, and 1000 μM OLE for 72 h promoted cell viability .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Incubation", "of", "human", "amelanotic", "melanoma", "cell", "line", "C32", "with", "100", "μM", ",", "400", "μM", ",", "and", "1000", "μM", "OLE", "for", "72", "h", "promoted", "cell", "viability", "." ] } ]
PMC10938336
The resultant PPI network was then subjected to Cytoscape version 3.8 to identify hub genes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resultant", "PPI", "network", "was", "then", "subjected", "to", "Cytoscape", "version", "3.8", "to", "identify", "hub", "genes", "." ] } ]
PMC11438317
P < 0.05 and **P < 0.01 for comparison of cells transfected with different plasmids and cells transfected with empty vector (pEF) C Activation of a luciferase reporter gene driven by the IL-2 minimal promoter in wild type and 494 Jurkat cells transfected with LYP and SLP76 as indicated.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", "and", "*", "*", "P", "<", "0.01", "for", "comparison", "of", "cells", "transfected", "with", "different", "plasmids", "and", "cells", "transfected", "with", "empty", "vector", "(", "pEF", ")", "C", "Activation", "of", "a", "luciferase", "reporter", "gene", "driven", "by", "the", "IL-2", "minimal", "promoter", "in", "wild", "type", "and", "494", "Jurkat", "cells", "transfected", "with", "LYP", "and", "SLP76", "as", "indicated", "." ] } ]
PMC5261804
We used the context-specific networks to compute the essentialities of 7906 PPIs in 206 cell lines from the project Achilles dataset and have reported these in S1 Table.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "the", "context-specific", "networks", "to", "compute", "the", "essentialities", "of", "7906", "PPIs", "in", "206", "cell", "lines", "from", "the", "project", "Achilles", "dataset", "and", "have", "reported", "these", "in", "S1", "Table", "." ] } ]
PMC10994876
As a transcriptional co-activator, YAP interacts with the TEAD transcription factor to promote the transcription of genes associated with cell proliferation and survival, such as c-MYC, CTGF, and CYR61.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "transcriptional", "co-activator", ",", "YAP", "interacts", "with", "the", "TEAD", "transcription", "factor", "to", "promote", "the", "transcription", "of", "genes", "associated", "with", "cell", "proliferation", "and", "survival", ",", "such", "as", "c-MYC", ",", "CTGF", ",", "and", "CYR61", "." ] } ]
PMC11628904
Strikingly, we found that 93% ± 5.8% of zone 2 keratinocytes remained viable 72 hpb demonstrating that cells in this zone were protected from death (Figure 2E).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Strikingly", ",", "we", "found", "that", "93", "%", "±", "5.8", "%", "of", "zone", "2", "keratinocytes", "remained", "viable", "72", "hpb", "demonstrating", "that", "cells", "in", "this", "zone", "were", "protected", "from", "death", "(", "Figure", "2E", ")", "." ] } ]
PMC9429973
Results: We defined reference values for known leukemia-associated immunophenotypes using normal bone marrow.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "We", "defined", "reference", "values", "for", "known", "leukemia-associated", "immunophenotypes", "using", "normal", "bone", "marrow", "." ] } ]
PMC11806182
Heat maps were generated to visualize cellular subtype abundance differences between high and low miR-330 expression samples.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heat", "maps", "were", "generated", "to", "visualize", "cellular", "subtype", "abundance", "differences", "between", "high", "and", "low", "miR-330", "expression", "samples", "." ] } ]
PMC11790971
First, due to constraints in availability, our investigation focused on a specific set of CHO cell lines used in mAbs production.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "First", ",", "due", "to", "constraints", "in", "availability", ",", "our", "investigation", "focused", "on", "a", "specific", "set", "of", "CHO", "cell", "lines", "used", "in", "mAbs", "production", "." ] } ]
PMC9429973
We observed significantly lower numbers of IFN-γ spot forming units after stimulation with peptides from both the S protein (p=0.0068) and the M plus N proteins (p=0.0067; Figure 1B) in the transplant group as opposed to the control group.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "observed", "significantly", "lower", "numbers", "of", "IFN-γ", "spot", "forming", "units", "after", "stimulation", "with", "peptides", "from", "both", "the", "S", "protein", "(", "p=0.0068", ")", "and", "the", "M", "plus", "N", "proteins", "(", "p=0.0067", ";", "Figure", "1B", ")", "in", "the", "transplant", "group", "as", "opposed", "to", "the", "control", "group", "." ] } ]
PMC11001582
On DIV 3, neural progenitor cells were dissociated with accutase and replated onto poly-l-ornithine (Merck) and laminin-coated plates in neuronal maintenance media: Neurobasal (Gibco), supplemented with 1 × B27 (Gibco), 10 ng ml BDNF (PeproTech), 10 ng ml NT-3 (PeproTech) and 1 µg ml laminin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "DIV", "3", ",", "neural", "progenitor", "cells", "were", "dissociated", "with", "accutase", "and", "replated", "onto", "poly-l-ornithine", "(", "Merck", ")", "and", "laminin-coated", "plates", "in", "neuronal", "maintenance", "media", ":", "Neurobasal", "(", "Gibco", ")", ",", "supplemented", "with", "1", "×", "B27", "(", "Gibco", ")", ",", "10", "ng", "ml", "BDNF", "(", "PeproTech", ")", ",", "10", "ng", "ml", "NT-3", "(", "PeproTech", ")", "and", "1", "µg", "ml", "laminin", "." ] } ]
PMC11025866
Two genes upregulated by the lytic cycle inhibitors, CHAC1 and SLC7A11, are related to redox status and the iron-dependent cell death pathway ferroptosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "genes", "upregulated", "by", "the", "lytic", "cycle", "inhibitors", ",", "CHAC1", "and", "SLC7A11", ",", "are", "related", "to", "redox", "status", "and", "the", "iron-dependent", "cell", "death", "pathway", "ferroptosis", "." ] } ]
PMC10565698
CircRNAs and miRNAs bind to AGO2 molecules, which are indicator proteins for circRNAs that exert sponge actions .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CircRNAs", "and", "miRNAs", "bind", "to", "AGO2", "molecules", ",", "which", "are", "indicator", "proteins", "for", "circRNAs", "that", "exert", "sponge", "actions", "." ] } ]
PMC11264242
FYN is a tyrosine kinase that promotes cancer growth, metastasis and therapeutic resistance, but SS18-SSX appears to negatively regulate FYN expression in synovial sarcoma cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FYN", "is", "a", "tyrosine", "kinase", "that", "promotes", "cancer", "growth", ",", "metastasis", "and", "therapeutic", "resistance", ",", "but", "SS18-SSX", "appears", "to", "negatively", "regulate", "FYN", "expression", "in", "synovial", "sarcoma", "cells", "." ] } ]
PMC8916024
The results showed that the abundance of microbes of all functions was significantly lower in the sediment than in the gut (P < 0.05).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "showed", "that", "the", "abundance", "of", "microbes", "of", "all", "functions", "was", "significantly", "lower", "in", "the", "sediment", "than", "in", "the", "gut", "(", "P", "<", "0.05", ")", "." ] } ]
PMC10969097
This systematic review aimed to explore the role of mushroom extracts in enhancing chemotherapy and reversing chemoresistance in cancer cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "systematic", "review", "aimed", "to", "explore", "the", "role", "of", "mushroom", "extracts", "in", "enhancing", "chemotherapy", "and", "reversing", "chemoresistance", "in", "cancer", "cells", "." ] } ]
PMC11733919
The effects of senolytic drugs alone were mild to moderate, and the addition of 17-DMAG as a component of functionalized nanoplatform significantly potentiated necrosis-based morphotypes of cell death in both fibroblast cell lines (Figure 3b).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effects", "of", "senolytic", "drugs", "alone", "were", "mild", "to", "moderate", ",", "and", "the", "addition", "of", "17-DMAG", "as", "a", "component", "of", "functionalized", "nanoplatform", "significantly", "potentiated", "necrosis-based", "morphotypes", "of", "cell", "death", "in", "both", "fibroblast", "cell", "lines", "(", "Figure", "3b", ")", "." ] } ]
PMC5925824
Human CD45 cells were also gated and enumerated, followed by subsequent gating on CD3cells, followed by CD4 cell and CD8 cell gating and enumeration, and finally PD-1 expressing cells were identified using appropriate IgG control.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "CD45", "cells", "were", "also", "gated", "and", "enumerated", ",", "followed", "by", "subsequent", "gating", "on", "CD3cells", ",", "followed", "by", "CD4", "cell", "and", "CD8", "cell", "gating", "and", "enumeration", ",", "and", "finally", "PD-1", "expressing", "cells", "were", "identified", "using", "appropriate", "IgG", "control", "." ] } ]
PMC10376064
Eventually, 40 µL of an MTT solution (5 mg/mL; Alfa Aesar) was added to each well, followed by incubation of 1 h. The supernatant was removed, and 100 µL of DMSO was added to each well.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eventually", ",", "40", "µL", "of", "an", "MTT", "solution", "(", "5", "mg/mL", ";", "Alfa", "Aesar", ")", "was", "added", "to", "each", "well", ",", "followed", "by", "incubation", "of", "1", "h.", "The", "supernatant", "was", "removed", ",", "and", "100", "µL", "of", "DMSO", "was", "added", "to", "each", "well", "." ] } ]
PMC6650823
The results showed that incorporation of the two important pharmacophoric groups of the two original molecules celecoxib and combretastatin A-4 in a single hybrid molecule leads to better biological activities of the new coxib-hybrided compounds.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "showed", "that", "incorporation", "of", "the", "two", "important", "pharmacophoric", "groups", "of", "the", "two", "original", "molecules", "celecoxib", "and", "combretastatin", "A-4", "in", "a", "single", "hybrid", "molecule", "leads", "to", "better", "biological", "activities", "of", "the", "new", "coxib-hybrided", "compounds", "." ] } ]
PMC11676674
The plate was centrifuged at 1500 rpm for 10 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "plate", "was", "centrifuged", "at", "1500", "rpm", "for", "10", "min", "." ] } ]
PMC11711663
The performance of our Cox model was assessed using log-likelihood ratio and score tests.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "performance", "of", "our", "Cox", "model", "was", "assessed", "using", "log-likelihood", "ratio", "and", "score", "tests", "." ] } ]
PMC11525028
ASNS promoted Asn biosynthesis, providing abundant amino acids for protein and nucleotide synthesis in osteosarcoma cells, and facilitated tumor proliferation and metastasis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ASNS", "promoted", "Asn", "biosynthesis", ",", "providing", "abundant", "amino", "acids", "for", "protein", "and", "nucleotide", "synthesis", "in", "osteosarcoma", "cells", ",", "and", "facilitated", "tumor", "proliferation", "and", "metastasis", "." ] } ]
PMC11314247
The results show that HO-AAVPA in MCF-7 at 5 h induced more apoptosis (68.4%) than no treatment (16.2%) and with DMSO (16.6%) (p ˂ 0.05) (Figure 1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "show", "that", "HO-AAVPA", "in", "MCF-7", "at", "5", "h", "induced", "more", "apoptosis", "(", "68.4", "%", ")", "than", "no", "treatment", "(", "16.2", "%", ")", "and", "with", "DMSO", "(", "16.6", "%", ")", "(", "p", "˂", "0.05", ")", "(", "Figure", "1", ")", "." ] } ]
PMC6742971
The compiled data from four independent experiments show that the differences were statistically significant, i.e., that the low avidity clones indeed exerted weaker killing as compared to the mixed clones as in comparison to the high avidity clones (Figure 1C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "compiled", "data", "from", "four", "independent", "experiments", "show", "that", "the", "differences", "were", "statistically", "significant", ",", "i.e.", ",", "that", "the", "low", "avidity", "clones", "indeed", "exerted", "weaker", "killing", "as", "compared", "to", "the", "mixed", "clones", "as", "in", "comparison", "to", "the", "high", "avidity", "clones", "(", "Figure", "1C", ")", "." ] } ]
PMC10729469
Although, this approach was effectively used in manipulating human Treg cells, mouse Treg cells are extremely difficult to transduce .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", ",", "this", "approach", "was", "effectively", "used", "in", "manipulating", "human", "Treg", "cells", ",", "mouse", "Treg", "cells", "are", "extremely", "difficult", "to", "transduce", "." ] } ]
PMC11306019
Conclusion: Due to the potential for these polyphenols to reduce the effectiveness of BTZ, it is advisable for MM patients undergoing BTZ treatment to reduce their consumption of foods high in VDM-containing polyphenols.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conclusion", ":", "Due", "to", "the", "potential", "for", "these", "polyphenols", "to", "reduce", "the", "effectiveness", "of", "BTZ", ",", "it", "is", "advisable", "for", "MM", "patients", "undergoing", "BTZ", "treatment", "to", "reduce", "their", "consumption", "of", "foods", "high", "in", "VDM-containing", "polyphenols", "." ] } ]
PMC11621493
Western blotting analysis of total (1,000 g supernatant), cytosolic (100,000 g supernatant), and membrane fractions (100,000 g pellet) of COS7 cells overexpressing His-tagged mPLA2G4D.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blotting", "analysis", "of", "total", "(", "1,000", "g", "supernatant", ")", ",", "cytosolic", "(", "100,000", "g", "supernatant", ")", ",", "and", "membrane", "fractions", "(", "100,000", "g", "pellet", ")", "of", "COS7", "cells", "overexpressing", "His-tagged", "mPLA2G4D", "." ] } ]
PMC9325715
The vibrational bands ν(C–O) of serine, aspartic, and glutamic acid appeared at 1159 cm and 1129 cm on a spectrum of native bLTF.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "vibrational", "bands", "ν(C", "–", "O", ")", "of", "serine", ",", "aspartic", ",", "and", "glutamic", "acid", "appeared", "at", "1159", "cm", "and", "1129", "cm", "on", "a", "spectrum", "of", "native", "bLTF", "." ] } ]
PMC9429973
Aims: This abstract, based on the interim analysis of the ALPINE trial, describes the effects of zanubrutinib monotherapy and ibrutinib monotherapy on the health-related quality of life (HRQoL).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "This", "abstract", ",", "based", "on", "the", "interim", "analysis", "of", "the", "ALPINE", "trial", ",", "describes", "the", "effects", "of", "zanubrutinib", "monotherapy", "and", "ibrutinib", "monotherapy", "on", "the", "health-related", "quality", "of", "life", "(", "HRQoL", ")", "." ] } ]
PMC10958426
The low cell-cell variation of cancer cells may be due to cancer cells were derived from the clone expansion of one or a few mutated cells, thus the cancer cells had a few states.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "low", "cell-cell", "variation", "of", "cancer", "cells", "may", "be", "due", "to", "cancer", "cells", "were", "derived", "from", "the", "clone", "expansion", "of", "one", "or", "a", "few", "mutated", "cells", ",", "thus", "the", "cancer", "cells", "had", "a", "few", "states", "." ] } ]
PMC11484188
The cells were incubated at 37˚C in a culture chamber for 48 h. Dual-Lumi™ dual-luciferase reporter gene detection kit (Beyotime Institute of Biotechnology) was used for detection and fluorescence value was recorded using a multifunctional microplate reader (TECAN-Spark; Tecan Group, Ltd.) comparing the Renilla luciferase activity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "incubated", "at", "37˚C", "in", "a", "culture", "chamber", "for", "48", "h.", "Dual-Lumi", "™", "dual-luciferase", "reporter", "gene", "detection", "kit", "(", "Beyotime", "Institute", "of", "Biotechnology", ")", "was", "used", "for", "detection", "and", "fluorescence", "value", "was", "recorded", "using", "a", "multifunctional", "microplate", "reader", "(", "TECAN-Spark", ";", "Tecan", "Group", ",", "Ltd.", ")", "comparing", "the", "Renilla", "luciferase", "activity", "." ] } ]
PMC11577421
Both native and cationized albumin variants have been extensively utilized in various drug delivery and gene therapy applications.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "native", "and", "cationized", "albumin", "variants", "have", "been", "extensively", "utilized", "in", "various", "drug", "delivery", "and", "gene", "therapy", "applications", "." ] } ]
PMC9812014
During natural infection, rabies lyssavirus retrograde axonal transport to the central nervous system (CNS) is a critical phase in pathogenesis .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "natural", "infection", ",", "rabies", "lyssavirus", "retrograde", "axonal", "transport", "to", "the", "central", "nervous", "system", "(", "CNS", ")", "is", "a", "critical", "phase", "in", "pathogenesis", "." ] } ]
PMC9429973
According to this data, it would be more fruitful consider the vaccination at least 6 months from the last rituximab administration, even though it’s necessary to take into account patient conditions and the epidemiological context.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "this", "data", ",", "it", "would", "be", "more", "fruitful", "consider", "the", "vaccination", "at", "least", "6", "months", "from", "the", "last", "rituximab", "administration", ",", "even", "though", "it", "’s", "necessary", "to", "take", "into", "account", "patient", "conditions", "and", "the", "epidemiological", "context", "." ] } ]
PMC11697189
We explored the prognostic value of HSP110, HSP90, HSP70 and HSP60 families in ccRCC and their role in tumor immune microenvironment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "explored", "the", "prognostic", "value", "of", "HSP110", ",", "HSP90", ",", "HSP70", "and", "HSP60", "families", "in", "ccRCC", "and", "their", "role", "in", "tumor", "immune", "microenvironment", "." ] } ]
PMC9516447
A427, HCT116, and PANC-1 cells were treated with either DMSO, HA15 (10μM) or YUM70 (10μM) for 48 hr.
[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A427", ",", "HCT116", ",", "and", "PANC-1", "cells", "were", "treated", "with", "either", "DMSO", ",", "HA15", "(", "10μM", ")", "or", "YUM70", "(", "10μM", ")", "for", "48", "hr", "." ] } ]
PMC11757131
Data are shown as mean ± standard error of mean; means not sharing the same letter are different (p < 0.05).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "mean", "±", "standard", "error", "of", "mean", ";", "means", "not", "sharing", "the", "same", "letter", "are", "different", "(", "p", "<", "0.05", ")", "." ] } ]
PMC9532503
As per the previous reports, 8X UMG increase the galactosylation up to 21% .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "per", "the", "previous", "reports", ",", "8X", "UMG", "increase", "the", "galactosylation", "up", "to", "21", "%", "." ] } ]
PMC11040965
U266 and RPMI 8226 cells were transfected with 10 µM miRNA mimic negative control (miR-NC) or miR29b mimic (miR29b) for 72 h. A Levels of miR29b in transfected cells normalized to RNU44 and expressed as fold change relative to the average value for untransfected cells (real-time PCR and 2 method).
[ { "tags": [ "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "U266", "and", "RPMI", "8226", "cells", "were", "transfected", "with", "10", "µM", "miRNA", "mimic", "negative", "control", "(", "miR-NC", ")", "or", "miR29b", "mimic", "(", "miR29b", ")", "for", "72", "h.", "A", "Levels", "of", "miR29b", "in", "transfected", "cells", "normalized", "to", "RNU44", "and", "expressed", "as", "fold", "change", "relative", "to", "the", "average", "value", "for", "untransfected", "cells", "(", "real-time", "PCR", "and", "2", "method", ")", "." ] } ]
PMC9019892
Briefly, the cells were washed with cold PBS and lysed in RIPA buffer (Beyotime, Shanghai, China) with a protease inhibitor cocktail (CST).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "the", "cells", "were", "washed", "with", "cold", "PBS", "and", "lysed", "in", "RIPA", "buffer", "(", "Beyotime", ",", "Shanghai", ",", "China", ")", "with", "a", "protease", "inhibitor", "cocktail", "(", "CST", ")", "." ] } ]
PMC10154881
After transplantation of the NECTIN4‐expressing tumor cells, rMV‐SLAMblind significantly suppressed tumor growth in immunocompetent mice.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "transplantation", "of", "the", "NECTIN4‐expressing", "tumor", "cells", ",", "rMV‐SLAMblind", "significantly", "suppressed", "tumor", "growth", "in", "immunocompetent", "mice", "." ] } ]
PMC9429973
Studies show that eHealth is helpful in providing patient empowerment through e.g. providing high quality and timely information, enabling self-monitoring and shared decision making, but dropout rates are high and guidance for optimal implementation is lacking.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Studies", "show", "that", "eHealth", "is", "helpful", "in", "providing", "patient", "empowerment", "through", "e.g.", "providing", "high", "quality", "and", "timely", "information", ",", "enabling", "self-monitoring", "and", "shared", "decision", "making", ",", "but", "dropout", "rates", "are", "high", "and", "guidance", "for", "optimal", "implementation", "is", "lacking", "." ] } ]
PMC9429973
Those 4 patients who didn’t achieve PR received autologous CAR-T therapy afterwards and had responses better than PR (1 CR, 1 VGPR, 2 PR).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Those", "4", "patients", "who", "did", "n’t", "achieve", "PR", "received", "autologous", "CAR-T", "therapy", "afterwards", "and", "had", "responses", "better", "than", "PR", "(", "1", "CR", ",", "1", "VGPR", ",", "2", "PR", ")", "." ] } ]
PMC11258145
To investigate the influence of curcumin on model membrane systems, the following lipids were employed: phospholipids: 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine (DOPC); 1-hexacosanoyl-d4-2-hydroxy-sn-glycero-3-phosphocholine (Lyso PC); 1,2-dioleoyl-sn-glycero-3-phosphocholine (POPC); l-α-phosphatidylethanolamine (PE, Brain); 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), sphingomyelin (SM, Brain), 1,2-dipalmitoyl-sn-glycero-3-phospho-l-serine (DPPS), cholesterol (Chol).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "investigate", "the", "influence", "of", "curcumin", "on", "model", "membrane", "systems", ",", "the", "following", "lipids", "were", "employed", ":", "phospholipids", ":", "1,2-dipalmitoyl-sn-glycero-3-phosphocholine", "(", "DPPC", ")", ",", "1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine", "(", "DOPC", ")", ";", "1-hexacosanoyl-d4", "-", "2-hydroxy-sn-glycero-3-phosphocholine", "(", "Lyso", "PC", ")", ";", "1,2-dioleoyl-sn-glycero-3-phosphocholine", "(", "POPC", ")", ";", "l-α-phosphatidylethanolamine", "(", "PE", ",", "Brain", ")", ";", "1,2-dioleoyl-sn-glycero-3-phosphoethanolamine", "(", "DOPE", ")", ",", "sphingomyelin", "(", "SM", ",", "Brain", ")", ",", "1,2-dipalmitoyl-sn-glycero-3-phospho-l-serine", "(", "DPPS", ")", ",", "cholesterol", "(", "Chol", ")", "." ] } ]
PMC9000591
Interestingly, the SE4 fraction presented a very poor impact against Mino cells, as only 22.0% of apoptosis cells were recognized—even lower than the proportion of LCL cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "the", "SE4", "fraction", "presented", "a", "very", "poor", "impact", "against", "Mino", "cells", ",", "as", "only", "22.0", "%", "of", "apoptosis", "cells", "were", "recognized", "—", "even", "lower", "than", "the", "proportion", "of", "LCL", "cells", "." ] } ]
PMC9250505
On the second day, after three PBS washings, cells were subsequently incubated for 1 h with secondary antibodies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "second", "day", ",", "after", "three", "PBS", "washings", ",", "cells", "were", "subsequently", "incubated", "for", "1", "h", "with", "secondary", "antibodies", "." ] } ]
PMC11045125
Furthermore, we found that stable cell lines derived from the ΔEBNA2 + Myc lymphomas (grown off the feeder layer) also often express one or more pre-B cell and/or pro-B cell associated proteins (S4 Fig) and respond to IL7 cytokine treatment by inducing STAT5 tyrosine phosphorylation (Fig 7C), indicating that the IL7R is functional.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "found", "that", "stable", "cell", "lines", "derived", "from", "the", "ΔEBNA2", "+", "Myc", "lymphomas", "(", "grown", "off", "the", "feeder", "layer", ")", "also", "often", "express", "one", "or", "more", "pre-B", "cell", "and/or", "pro-B", "cell", "associated", "proteins", "(", "S4", "Fig", ")", "and", "respond", "to", "IL7", "cytokine", "treatment", "by", "inducing", "STAT5", "tyrosine", "phosphorylation", "(", "Fig", "7C", ")", ",", "indicating", "that", "the", "IL7R", "is", "functional", "." ] } ]
PMC11052306
More interestingly, a synergistic effect was observed in the combination of 2-G3-Cu48 with doxorubicin, ongoing from ca.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "interestingly", ",", "a", "synergistic", "effect", "was", "observed", "in", "the", "combination", "of", "2-G3-Cu48", "with", "doxorubicin", ",", "ongoing", "from", "ca", "." ] } ]
PMC10253973
The value for compound 45 was 1.5–1.6 µM after one hour of incubation and 1.2 µM after four hours .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "value", "for", "compound", "45", "was", "1.5–1.6", "µM", "after", "one", "hour", "of", "incubation", "and", "1.2", "µM", "after", "four", "hours", "." ] } ]
PMC11366496
In this study, we found that RNF122 is highly expressed in GBM and is closely related to the progression or prognosis of the disease, so it may become a new therapeutic target.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "found", "that", "RNF122", "is", "highly", "expressed", "in", "GBM", "and", "is", "closely", "related", "to", "the", "progression", "or", "prognosis", "of", "the", "disease", ",", "so", "it", "may", "become", "a", "new", "therapeutic", "target", "." ] } ]
PMC11489351
B, measured pHi (see Methods) in normal human mammary epithelial cells (MCF10A) that were left untreated (control) or treated for 24 h with complete media containing 25 μM EIPA (EIPA) to lower pHi or 30 mM NH4Cl (NH4Cl) to raise pHi.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "measured", "pHi", "(", "see", "Methods", ")", "in", "normal", "human", "mammary", "epithelial", "cells", "(", "MCF10A", ")", "that", "were", "left", "untreated", "(", "control", ")", "or", "treated", "for", "24", "h", "with", "complete", "media", "containing", "25", "μM", "EIPA", "(", "EIPA", ")", "to", "lower", "pHi", "or", "30", "mM", "NH4Cl", "(", "NH4Cl", ")", "to", "raise", "pHi", "." ] } ]
PMC11756514
Fractions in the peak signal were analyzed by SDS-PAGE, and fractions D7-E1 were pooled, as shown in Supplementary Figures S2A, B .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fractions", "in", "the", "peak", "signal", "were", "analyzed", "by", "SDS-PAGE", ",", "and", "fractions", "D7-E1", "were", "pooled", ",", "as", "shown", "in", "Supplementary", "Figures", "S2A", ",", "B", "." ] } ]
PMC10938336
To assess druglikeness, the compounds were screened based on their oral bioavailability (OB) values, with those exceeding 0.30 being considered.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "druglikeness", ",", "the", "compounds", "were", "screened", "based", "on", "their", "oral", "bioavailability", "(", "OB", ")", "values", ",", "with", "those", "exceeding", "0.30", "being", "considered", "." ] } ]
PMC10890307
The cell lines grew in monolayers and were harvested by trypsinization.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "lines", "grew", "in", "monolayers", "and", "were", "harvested", "by", "trypsinization", "." ] } ]
PMC8632470
Our result is in accordance with that of Dugan .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "result", "is", "in", "accordance", "with", "that", "of", "Dugan", "." ] } ]
PMC11257988
Chen et al. found that SHP2 is activated by peptides and proteins containing appropriately spaced phosphotyrosine residues, which bind the N-terminal and C-terminal SH2 domains in a bidentate manner, releasing it from the self-inhibitory interface, and make the active site available for substrate recognition and turnover.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chen", "et", "al.", "found", "that", "SHP2", "is", "activated", "by", "peptides", "and", "proteins", "containing", "appropriately", "spaced", "phosphotyrosine", "residues", ",", "which", "bind", "the", "N-terminal", "and", "C-terminal", "SH2", "domains", "in", "a", "bidentate", "manner", ",", "releasing", "it", "from", "the", "self-inhibitory", "interface", ",", "and", "make", "the", "active", "site", "available", "for", "substrate", "recognition", "and", "turnover", "." ] } ]
PMC11371747
Trizol and RT-qPCR kit were from Invitrogen/Thermo Fisher Scientific (Bleiswijk, the Netherlands).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Trizol", "and", "RT-qPCR", "kit", "were", "from", "Invitrogen/Thermo", "Fisher", "Scientific", "(", "Bleiswijk", ",", "the", "Netherlands", ")", "." ] } ]
PMC11674146
In our current study, so far as we are concerned, we firstly proved the oncogenic effects of CLP36 on lymphoma.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "our", "current", "study", ",", "so", "far", "as", "we", "are", "concerned", ",", "we", "firstly", "proved", "the", "oncogenic", "effects", "of", "CLP36", "on", "lymphoma", "." ] } ]
PMC11754436
Tunel results showing apoptosis level for MG63 cells in each group. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tunel", "results", "showing", "apoptosis", "level", "for", "MG63", "cells", "in", "each", "group", ".", "(" ] } ]
PMC11088135
These findings suggest that lncRNA NUTM2A-AS1 negatively regulates the expression of miR-376a-3p in glioma cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "that", "lncRNA", "NUTM2A-AS1", "negatively", "regulates", "the", "expression", "of", "miR-376a-3p", "in", "glioma", "cells", "." ] } ]
PMC9429973
Methods: Gene expression profiling of HSCs from th3 mice was assessed by RNAseq.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Gene", "expression", "profiling", "of", "HSCs", "from", "th3", "mice", "was", "assessed", "by", "RNAseq", "." ] } ]
PMC11126803
Mechanism dissection of how ERβ alters ZEB1 expression: via transcriptional regulation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanism", "dissection", "of", "how", "ERβ", "alters", "ZEB1", "expression", ":", "via", "transcriptional", "regulation", "." ] } ]
PMC11769516
In various studies determining the pathogenesis of neurotoxicity, neuroblastoma (SH-SY5Y) is used as a cell model .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "various", "studies", "determining", "the", "pathogenesis", "of", "neurotoxicity", ",", "neuroblastoma", "(", "SH-SY5Y", ")", "is", "used", "as", "a", "cell", "model", "." ] } ]
PMC11591794
The reason why the time-dependent IC50 values of GA detected in this study differ from the IC50 values obtained in other cancer studies is due to the fact that the MTT test, which has been used in cancer research for over 30 years, is rarely consistent for a given chemical.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reason", "why", "the", "time-dependent", "IC50", "values", "of", "GA", "detected", "in", "this", "study", "differ", "from", "the", "IC50", "values", "obtained", "in", "other", "cancer", "studies", "is", "due", "to", "the", "fact", "that", "the", "MTT", "test", ",", "which", "has", "been", "used", "in", "cancer", "research", "for", "over", "30", "years", ",", "is", "rarely", "consistent", "for", "a", "given", "chemical", "." ] } ]
PMC11040965
GAPDH was chosen over β2m and TBP because it resulted to be the most stable housekeeping gene under our experimental conditions, according to the NormFinder algorithm .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GAPDH", "was", "chosen", "over", "β2", "m", "and", "TBP", "because", "it", "resulted", "to", "be", "the", "most", "stable", "housekeeping", "gene", "under", "our", "experimental", "conditions", ",", "according", "to", "the", "NormFinder", "algorithm", "." ] } ]
PMC11711345
Cuminaldehyde has induced cancer cell death in vitro and in vivo in COLO 205 (colorectal adenocarcinoma) (IC50 16.31 µM, and a 48.9 - 69.4% reduction in tumors) , NCI-H520 (lung squamous carcinoma, with an IC50 33.29 µM, and ~45%) , and A549 (IC50 18.33 μM, ~50%), which act on topoisomerases 1 and 2 and suppress, in a dose-dependent manner (≤ 0.25 mM), the formation of melanin in B16-F10 cells without affecting cell growth .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cuminaldehyde", "has", "induced", "cancer", "cell", "death", "in", "vitro", "and", "in", "vivo", "in", "COLO", "205", "(", "colorectal", "adenocarcinoma", ")", "(", "IC50", "16.31", "µM", ",", "and", "a", "48.9", "-", "69.4", "%", "reduction", "in", "tumors", ")", ",", "NCI-H520", "(", "lung", "squamous", "carcinoma", ",", "with", "an", "IC50", "33.29", "µM", ",", "and", "~45", "%", ")", ",", "and", "A549", "(", "IC50", "18.33", "μM", ",", "~50", "%", ")", ",", "which", "act", "on", "topoisomerases", "1", "and", "2", "and", "suppress", ",", "in", "a", "dose-dependent", "manner", "(", "≤", "0.25", "mM", ")", ",", "the", "formation", "of", "melanin", "in", "B16-F10", "cells", "without", "affecting", "cell", "growth", "." ] } ]
PMC11700340
The Discovery Studio visualizer generated three-dimensional (3D) and two-dimensional (2D) interactive images.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Discovery", "Studio", "visualizer", "generated", "three-dimensional", "(", "3D", ")", "and", "two-dimensional", "(", "2D", ")", "interactive", "images", "." ] } ]
PMC11543935
A systematic review by Hogenes et al. showed that the quality of studies investigating the effect of electroporation was mainly low for 14 out of 18 studies (78 %).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "systematic", "review", "by", "Hogenes", "et", "al.", "showed", "that", "the", "quality", "of", "studies", "investigating", "the", "effect", "of", "electroporation", "was", "mainly", "low", "for", "14", "out", "of", "18", "studies", "(", "78", "%", ")", "." ] } ]
PMC11787381
Indeed, these drugs have undergone Chemistry, Manufacturing, and Controls (CMC) studies, as well as regulatory toxicological studies, making them liable to be safely produced and developed as medications, since they are already available in the market.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Indeed", ",", "these", "drugs", "have", "undergone", "Chemistry", ",", "Manufacturing", ",", "and", "Controls", "(", "CMC", ")", "studies", ",", "as", "well", "as", "regulatory", "toxicological", "studies", ",", "making", "them", "liable", "to", "be", "safely", "produced", "and", "developed", "as", "medications", ",", "since", "they", "are", "already", "available", "in", "the", "market", "." ] } ]
PMC9429973
Methods: Pts aged ≥ 65 years, enrolled between May 2013 and November 2014 from 183 sites across all geographical regions, were stratified by simplified MIPI score (low vs intermediate vs high risk) and were randomized 1:1 to Ibr (560 mg orally daily) or placebo (Pbo), plus 6 cycles of B (90 mg/m) and R (375 mg/m).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Pts", "aged", "≥", "65", "years", ",", "enrolled", "between", "May", "2013", "and", "November", "2014", "from", "183", "sites", "across", "all", "geographical", "regions", ",", "were", "stratified", "by", "simplified", "MIPI", "score", "(", "low", "vs", "intermediate", "vs", "high", "risk", ")", "and", "were", "randomized", "1:1", "to", "Ibr", "(", "560", "mg", "orally", "daily", ")", "or", "placebo", "(", "Pbo", ")", ",", "plus", "6", "cycles", "of", "B", "(", "90", "mg/m", ")", "and", "R", "(", "375", "mg/m", ")", "." ] } ]
PMC9856122
The anti-HIV activity of salsolinol, tetrahydropapaveroline, and N, N-dimethylsalsolinol was performed on Raji cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "anti-HIV", "activity", "of", "salsolinol", ",", "tetrahydropapaveroline", ",", "and", "N", ",", "N-dimethylsalsolinol", "was", "performed", "on", "Raji", "cells", "." ] } ]
PMC11392912
Band showing Clo-miR-14 PCR product run on 1.5% agarose gel from HC (N=8), RA (N=8), and Curcuma longa (turmeric). (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Band", "showing", "Clo-miR-14", "PCR", "product", "run", "on", "1.5", "%", "agarose", "gel", "from", "HC", "(", "N=8", ")", ",", "RA", "(", "N=8", ")", ",", "and", "Curcuma", "longa", "(", "turmeric", ")", ".", "(" ] } ]
PMC11767817
As a result, we presented two curcumin derivatives with modified aryl side moieties and a seven-carbon linker.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "we", "presented", "two", "curcumin", "derivatives", "with", "modified", "aryl", "side", "moieties", "and", "a", "seven-carbon", "linker", "." ] } ]
PMC11612315
The analgesic potential of exendin 9–39 was confirmed in an acute pain mouse model, followed by an assessment of its effectiveness in a chronic pain model.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "analgesic", "potential", "of", "exendin", "9–39", "was", "confirmed", "in", "an", "acute", "pain", "mouse", "model", ",", "followed", "by", "an", "assessment", "of", "its", "effectiveness", "in", "a", "chronic", "pain", "model", "." ] } ]
PMC11087301
The VM could be established either in patterned matrix or tubular form.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "VM", "could", "be", "established", "either", "in", "patterned", "matrix", "or", "tubular", "form", "." ] } ]
PMC11687167
SREBP2 had been shown to upregulate PCSK9 expression in several previous studies [110–112].
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SREBP2", "had", "been", "shown", "to", "upregulate", "PCSK9", "expression", "in", "several", "previous", "studies", "[", "110–112", "]", "." ] } ]
PMC6461034
The tube should not be warm or cold.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tube", "should", "not", "be", "warm", "or", "cold", "." ] } ]