Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Three could not be matched, 2 with T-PLL treated with alemtuzumab and one with plasmablastic lymphoma and newly diagnosed HIV infection.
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PMC11522251
Post 4 h, the culture media was thrown away, and then each well received 150 μl of Dimethyl sulfoxide (DMSO) to dissolve the formaldehyde dimethyl sulfoxide.
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PMC9429973
Methods: We enrolled a series of 20 consecutive patients who suffered from various hematological malignancies with profound B-cell lymphopenia and COVID-19 pneumonia between December 2020 and May 2021.
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PMC11047729
Angelica sinensis polysaccharide (ASP) is a water-soluble substance that can be found in Angelica sinensis and is used in traditional Chinese medicine.
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PMC11615828
Data are shown as mean ± SEM.
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PMC11261875
GLUT play a significant role in GIST progression and response to treatment.
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PMC11472639
Myeloma is characterised by the accumulation of clonal plasma cells in the bone marrow (Kyle et al., 2003) and likely develops from asymptomatic precursor conditions known as monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM) (Kyle et al., 2002; Landgren et al., 2009).
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PMC11422497
Subsequently, PBS was employed to remove any cellular debris, and the cells were cultured in McCoy’s 5 A medium with low serum at 37 ℃ and 5% CO2.The widths of the scratches were observed and documented at 0-, 24-, and 48- hours post-scratching using an inverted biological microscope (CX53, Olympus, Japan).
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PMC7351993
The microchannels including the inlets, outlets, and on-chip dual-membrane pumps were patterned by the deep reactive ion etching (DRIE) technique.
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PMC9503669
Infection of these animals with HIV-1 results in viremia and rapid depletion of CD4 T cells from both the blood and tissue compartments.
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PMC11638288
Fig. 1Molecular structures of NKp46.
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PMC10919056
GJA5 and GJB1, which are GRPS markers of ccRCC patients, were identified through LASSO and Cox regression models.
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PMC11389534
During EBV replication in Burkitt lymphoma cell lines, the EBV‐encoded BILF1 mediates MAVS UFMylation, targeting it for lysosomal degradation and potentially disrupting RIG‐I‐MAVS‐driven NLRP3 inflammasome activation and IRF3 responses.
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PMC11756514
The culture was grown at 37°C with agitation to an OD550 ≈ 0.5, followed by 1 mM isopropyl-beta-D-thiogalactoside (IPTG) induction.
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PMC11225860
Combination treatment maintained a low level of 16n aneuploid cells at both time points (4% each), and increased levels of 8n aneuploid cells between days three and five (2% and 12%).
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PMC11206502
It promotes genomic instability, which stimulates tumorigenesis and metastasis, and decreases susceptibility to anticancer therapy .
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PMC11643361
as opposed to homoscorpionates, where donor atoms come from equivalent moieties.
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PMC6835428
Unfortunately, no data about the effects on animal survival were reported.
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PMC7887261
FCS files were analyzed by FlowJo 10.5 software.
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PMC11040965
A Levels of miR29b and DNMT3B mRNA in immunomagnetically purified plasma cells (CD138) from bone marrow of MGUS (n = 20) and MM (n = 25) patients.
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PMC11502327
It was found that compared with previous synthetic polymer micelles encapsulated ceramides, the new nanomicelles not only promoted drug delivery to OC cells, but also overcame tissue barriers, inhibited glycosylation, better participating in restoring tumor suppressor activity in OC cells carrying p53 mutations.
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PMC9429973
Methods: A retrospective cross-sectional study was performed on adult patients who had a BMAB in a day procedure operating theatre over the period from 1 July 2018 to 30 March 2019.
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PMC3995603
Glacial acetic acid was of analytical reagent grade and was procured from Junsei (Tokyo, Japan).
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PMC9712534
G180 is located in the ATP-lid structure (Fig. 1b), and the G180I substitution abolishes ATP-binding of TOP2B and consequently prevents the formation of the closed clump structure of ICRF-bound TOP2B on DNA strands.
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PMC10870498
HEK-293T cells were maintained in the DMEM (Thermo Fisher Scientific, Waltham, MA, USA) containing 10% FBS and 1% penicillin/streptomycin.
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PMC9429973
At diagnosis, cytogenetic and molecular analysis were not done in our patients.
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PMC9429973
In thalassemia, RBCs have an imbalance in the ratio of α/β globin chains and aggregated, unpaired globin chains increase metabolic demands.
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PMC3675084
We followed the cell cycle progression in both parental and paclitaxel-resistant cells after BPR0L075 treatment.
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PMC11775197
These effects are strongly linked to E-cadherin, β-catenin, and Drg-1 .
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PMC11682172
Analysis of coronin-1A protein in primary breast cancer samples clearly showed significantly higher coronin-1A expression levels in primary breast cancer samples of patients who developed brain metastasis than those observed in breast cancer tissue samples of patients who had metastases in organs other than brain (p = 0.0035; Fig. 5a-c).
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PMC11477621
H NMR (400 MHz, CDCl3) δ 7.42 (s, 1H), 7.22 (d, J = 8.3 Hz, 1H), 7.05–7.00 (overlap, 2H), 6.39 (d, J = 3.0 Hz, 1H), 4.03 (t, J = 7.0 Hz, 2H), 2.46 (s, 3H), 1.96 (t, J = 7.5 Hz, 2H), 1.80–1.70 (m, 2H), 1.56–1.46 (m, 2H), 1.28–1.20 (overlap, 4H).
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PMC7887261
GO enrichment analysis highlighted genes involved in replicative senescence (which triggers a DNA damage response); whereas KEGG pathway analysis revealed that genes were involved in small cell LC (Supplementary Table 5).
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PMC9429973
Aims: The purpose of this paper is to describe the patient profiles, aetiologies and survival outcomes of adult patients with secondary HLH in a tertiary hospital in Singapore.
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PMC11461874
The lysate was centrifuged (5 min, 14,000 rpm), and the precipitate was rinsed by buffer A and centrifuged (5 min, 14,000 rpm).
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PMC9786247
Control cells were mock inoculated with NaCl solution (negative controls) or stimulated with E. coli O111:B4 LPS (5 µg/mL; Sigma-Aldrich) as positive controls.
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PMC9325715
bLTF is the protein belonging to the transferrin family, which are the non-heme iron-binding proteins.
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PMC8633974
Primary human monocyte derived macrophages were infected using HIV-1ADA at an MOI of 0.01.
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PMC11755519
Another hallmark of cancer is increased genomic instability, which was assessed by examining the expression levels of the antioxidant stress gene: SOD and the DDR genes GADD45A, GADD45B, GADD45G, and RAD50.
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PMC11618052
The impact of compound 8g on cell cycle progression and apoptosis induction was examined in A-549 cells.
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PMC9429973
Results: Overall, 59 patients were enrolled, 50 patients completed year 1 visit, and 32 patients completed the final visit (9 died, 9 discontinued, and 9 were lost to follow-up).
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PMC11706776
RNA-seq data for A-673/TR/SHEF without induction (day 0) and with induction of the shRNA targeting EWS::FLI1 (day 7) came from Gene Expression Omnibus (GEO) GSE164373 , also in triplicates for each condition.
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PMC7602170
The downregulation of p-mTOR and mTOR was observed in HBV-associated HCC.
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PMC4395774
To determine if perforin gene transfer could restore cytotoxic function in primary effector cells, splenic NK and T cells derived from perforin-deficient mice (prf) were transduced with either the PGK.PRF or PRF.PRF vector.
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PMC11754432
Psoriasis is a chronic inflammatory skin disease affecting approximately 3% of the population worldwide .
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PMC8557138
For example, during the process of fabrication, micro-molds, sacrificial materials, liquid templates provide support to geometries inside hydrogel materials (McNulty et al. 2019).
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PMC11518702
HGAL attenuation of DLBCL and Burkitt lymphoma cell migration (as mediated via a PDZ-RhoGEF, RhoA Rock pathway)—studies of DLBCL and Burkitt lymphoma cell line migration (in response to SDF1) are summarized.
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PMC10914904
This activation subsequently leads to an increase in the phosphorylation of IκB, followed by its degradation and the activation of NF-κB .
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PMC10891340
These data indicated that CCCP can therapeutically inhibit virus infection in DEFs.
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PMC11240571
Blots were blocked using 5% nonfat dry milk for 1 h at room temperature and incubated overnight at 4 °C with the corresponding primary antibody at the dilution recommended by the supplier, followed by incubation with an HRP-labeled secondary antibody (Dako, Santa Clara, CA, USA, cat.
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PMC9429973
Beyond this threshold, there were also important questions about wide-ranging topics, including physical activity, genetic testing, cognitive and immune functioning, minimal residual disease, and familial screening (see Table).
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PMC11594641
The membranes were incubated with primary antibodies overnight at 4 °C.
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PMC11075223
The crude extracts and monomers of Cimicifugae Rhizoma exhibit extensive pharmacological activity, including anti-inflammatory, antitumor, antiviral, anti-osteoporosis, antioxidant, neuroprotective, angiogenesis and analgesic activities .
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PMC11545868
They initiate the cell death process by cleaving and activating downstream effector caspases.
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PMC11748335
In addition to H3K27me3, H3K9me3 is also a histone modification associated with gene suppression.
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PMC11683130
Ang II interacts with AT1R to play a pro-inflammatory role, while Ang II and AT2R play an anti-inflammatory role (47, 170).
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PMC10899471
These findings indicated that BATF2 was downregulated in sarcoma and negatively associated with the prognosis of sarcoma patients.
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PMC9429973
Median time to response was 1 month and all patients achieved their best response within 3 months.
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PMC9516447
DNA oligos with sequences specifically targeting GRP78 were synthesized by Integrated DNA Technologies (Coralville, IA) and annealed in NEB Buffer 2.
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PMC11295144
We have demonstrated previously that stable expression of synaptic α1β2γ2-GABAARs in HEK293 cells promotes the adhesion of GABAergic axons and the formation of functional synapses when these cells are co-cultured with the GABAergic medium spiny neurons (Fuchs et al., 2013; Brown et al., 2014, 2016).
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PMC11804588
Moreover, it can be extended to single-cell resolution, to enable detection of distinct cell types within heterogeneous tissues and assess TF footprints genome-wide in each of the cellular populations.
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PMC10761218
Changes in cell morphology were observed using an inverted microscope.
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PMC11769522
In vitro models mimicking the features of skin inflammation in humans by keratinocyte activation using cytokine cocktails have been reported .
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PMC9429973
F. Modemann, L. Ramke, J. Muschhammer, L. Behrmann, V. Thaden, M. Schoof, C. Göbel, S. Neyazi, C. Bokemeyer, J. Wellbrock, U. Schüller, W. Fiedler Department of Oncology and Hematology, University Medical Center Hamburg-Eppendorf; Mildred Scheel Cancer Career Center, University Medical Center Hamburg-Eppendorf; Research Institute Children’s Cancer Center Hamburg; Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Background: SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a) is the central ATPase containing enzyme in the SWI/SNF- (switch/sucrose non-fermentable) complex, which influences gene transcription by regulating chromatin accessibility.
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PMC11155445
The nature of halide ions also affects the emission energy of complexes mainly due to the involvement of a halide-to-ligand charge transfer (XLCT) in excited states.
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PMC10940855
One hour after antibody injection, mice were euthanized and femurs were collected.
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PMC9429973
In particular, there was an association between ALL diagnosis and the aforementioned alleles of these three genes studied (G for Casp8, T for Casp10, G for FAS).
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PMC10988808
Quantification of protein expression revealed that overexpression of YAP reversed the reduction of ITGA3 and CCND1 caused by CCDC25 overexpression.
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PMC10890307
Hence, our results provide an understanding of metabolic responses that tumor cells develop to survive under stressful conditions, providing clues for developing promising opportunities to improve traditional cancer therapies.
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PMC7823217
These bioprinted cancer models can also complement human clinical trials where the effectiveness and mechanisms of drug candidates can be tested on individual basis taking into the account not just the molecular subtype of the tumor but also the differences in age, sex and ethnicity as well as identifying the most optimal doses of chemotherapeutic agents .
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PMC11095939
WB of Mecp2, pRb, Cyclin D1, Cyclin E1, Cyclin A2, and Cyclin B1 in control and Mecp2 OE 3T3 cells released from SS-induced quiescence at the indicated time points. (
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PMC11574271
E Transfection of 5637-shRON cells with a HIF-2α plasmid and J82-oeRON cells with HIF-2α-targeting siRNA was performed, followed by western blot analysis to assess the expression levels of HIF-2α and MMP12.
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PMC11774112
Characterization of Co-PHRD micelles. (
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PMC9119314
These data are consistent with the previous work (Oluwafemi et al., 2009), in which 2 was shown to have potent, selective activity against T. brucei (strain 427) in vitro as well as oral activity against T. brucei infection in rats, while 1 was 100-fold less potent than 2 against T. brucei in vitro.
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PMC10142392
Amphiphilic micelles of a multi-armed copolymer based on PCL/PEG and cyclodextrin developed by Xiufang Li et al. , have shown great efficiency in encapsulating DOX due to the adequate space present in this system.
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PMC9429973
We recommend all qualified centers to evaluated clonality relatedness of RS DLBCL patients.
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PMC11461833
Gene-gene interaction network among STXBP5, LMNA and LMNB1.
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PMC11761919
The cytokine levels in the Micro-E/Fiber 2-PINs group were higher than those in the Micro-E/Fiber 2-inulin group (p < 0.01) (Fig. 4E).
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PMC6684588
Although the role of satellite cells in muscle hypertrophy remains controversial, a decline in satellite cells has a major impact on myogenic competence, and inhibition of ActRIIB-pathway signaling with ActRIIB-Fc restores the regenerative potential of a reduced satellite cell population.
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PMC8701144
As seen in Figure 2, the majority of E1B-55k protein indeed accumulated in large cytoplasmic aggregates that co-localized with the TNKS stained cytoplasmic bodies.
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PMC11697703
Library concentrations were in the nano-molar range.
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PMC5330095
Based on the activity of the single dose, a dose-response assay was carried out to determine the IC50.
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PMC11591794
After the statistical determination of the IC50 value, the viability of the HeLa cell line decreased significantly.
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PMC11768281
Directing an advanced, boosted immunity against malaria does not imply stimulating all T-cells.
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PMC11592008
We found a correlation between the mRNA and protein expression profiles of NLRP1, IL-1β, and caspase-1.
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PMC9429973
PPP1R15A in AML compared to controls was 12-fold up-regulated in responders [p=0.001] and 16-fold up-regulated in non-responders [p=0.001]. (
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PMC11700247
All animal studies were approved by the Institutional Animal Care and Use Committee (IACUC) and the University Laboratory Animal Resources at the University of Pennsylvania.
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PMC11738017
Our study also included a data set generated by the Multiple Myeloma Research Foundation Personalized Medicine Initiative (https://research.themmrf.org) with newly diagnosed patients with MM who were enrolled in the CoMMpass trial (phs000748.v1.p1).
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PMC11593031
Additionally, deletions in the short arm of chromosome 1 (1p), also one of the most common chromosomal alterations in NBs, are associated with an unfavorable prognosis .
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PMC10878518
Moreover, hTERT expression was positive in 46% of bone and soft-tissue sarcomas and 13% of benign bone and soft-tissue tumors .
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PMC9596868
Fig. 4A shows the images of the colonies obtained upon individual and combination treatment with quercetin and MST-312 and Fig. 4 B–D shows their quantification.
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PMC11637820
Cells were then transferred to RPMI 1640 media and cultured for another 24 h. Positive controls were included by treating the cells in similar conditions with 500 ng/ml lipopolysaccharide, and the feed gas-treated cells served as a negative control.
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PMC11049548
This observation is difficult to rationalize; it has been reported that inosine released by dead and dying cells mediates tumor cell proliferation via purinergic receptors , but here, we could only observe increased intracellular levels and not release into the media.
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PMC11087055
The initiation of the polonaise movements was set as Time 0 (t=0). (
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PMC5810978
We could not detect any substantial increase of BoNoV RNA levels in primary calf cells from ileal mucosa under the test conditions.
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PMC10988555
The superposition of the experimental spectra with the calculated excitations is exceptional for complexes 1–3, while for complex 4, the agreement is much worse.
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PMC11012313
Briefly, the BJAB cell lines were stably transfected using electroporation with a vector that provided for selection with gentamycin and hygromycin and included a gene encoding LMP2A (LMP2A1.1) or the vector alone (Vector.1) .
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PMC9429973
A series of ChIP-seq assays were performed in multiple AML cell lines to profile chromatin occupancy by Fibrillarin (FBL), a catalytic component of C/D box ribonucleoproteins (snoRNPs), as well as to observe the remodelling of chromatin states marked by H3K27ac and H3K9me3 upon shRNA-mediated knockdown of FBL.
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PMC11545737
Pyroptosis activation in epithelia does not always favour bacterial crossing, but can also contrast it.
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PMC9429973
Summary/Conclusion: CsA is an immunosuppressive drug widely used in aplastic anemia and other bone marrow failure syndromes, due to suppression of haematopoiesis by autoreactive T- lymphocytes.
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PMC11768927
By downregulating Mx1, they observed increased VSV sensitivity, indicating that targeting Mx1 could improve oncolytic efficacy.
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