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OTAR3088
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BioData-CellLine_annotated

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PMC11707577
The possibility that the irradiation itself may cause tissue damages was tested by irradiating for the same periods living polyps in absence of any phage treatment.
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PMC11306331
A pHR expression plasmid and lentiviral packaging plasmids were co-transfected using the Fugene HD transfection reagent (Promega).
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PMC11228511
High-magnification images of the boxed areas are shown to the Right. (
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PMC11760643
A mouse multiple myeloma cell line producing an IgG2b isotype control mAb (clone MPC‐11) was obtained from CellBank Australia (Westmead, Australia) and maintained in DMEM (Sigma Aldrich) containing 20% horse serum (Sigma Aldrich) and 2 mM GlutaMAX.
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PMC11549062
The lysosomal transport led to a phenotypic switch of the VSMCs toward a foam cell‐like cell phenotype, which was suspected to reduce plaque stabilizing properties of VSMCs .
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PMC11489351
High CD70 expression is associated with EMT of breast epithelial cells (71), a process associated with increased pHi (21), though no known pH-dependent molecular drivers of EMT are characterized.
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PMC11190538
The mixture was allowed to stand for 30 min in the dark at room temperature before the absorbance was measured at 725 nm using a spectrophotometer (model 2010, Cecil Instr.
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PMC9429973
Methods: We analyzed 545 AML pts (median age at diagnosis 62, range 21-77 years) consolidated by reduced-intensity (23%) or non-myeloablative (77%) allogeneic HSCT.
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PMC9920575
The translocation of phosphatidylserine, indicated by annexin V coupled to FITC, showed that exposure of HeLa cells to S. chinantlense extract increased early apoptotic cells (lower-right quadrants) to 51.7% vs. 5.8% in the control and increased late apoptotic cells (upper -right quadrants) to 41.2% vs. 10.7% in the control; in contrast, this effect was minimal in HaCaT cells, with early apoptotic cells to 2.86% vs. 1.64% in the control and late apoptotic cells to 5.80 vs. 5.26 in the control.
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PMC8567602
SMARCB1 knockdown in synovial sarcoma cells also reduced the stability of the CBAF-specific subunit, DPF2, which only assembles into SMARCB1-containing CBAF complexes (26).
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PMC9429973
Data presented are from key cycles (7 and 13), corresponding to 6 and 12 months of treatment, respectively.
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PMC11785489
When screening for Jurkat activation following coculture with 293T cells, Jurkat cells were sorted from 293T cells based on CD40 expression (APC anti-mouse CD40 clone 3/23), and then stained for CD69 expression (PE anti-human CD69, clone FN50).
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PMC11536589
The ultimate concentration of DMSO did not exceed 0.1%.
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PMC11127909
A The proliferation of 143B-V and 143B-EFHD1 cells was detected by EdU staining, N = 3.
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PMC11487720
By fluorescent immunostaining, UV/cold shock-induced nuclear co-localization of endogenous WWOX with TRAF2 occurred in COS7 cells (Fig. 7A).
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PMC11367146
Statistical significance were calculated by using one way ANOVA followed by Tukey test.
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PMC3995603
Moreover, it has been reported various compounds including coumarins (scoparone, scopoletin, scopolin, etc.),
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PMC9429973
Four pts were excluded from analysis due to incomplete data.
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PMC10940855
Heat map is relative to the maximum and minimum reads for each gene.
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PMC10873328
The cell proliferation (c), migration (d) and invasion (e) after knocking down TGFBI in 3AO cell line.
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PMC11055323
f A Model for condensate remodeling as a driver for synovial sarcoma.
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PMC6835762
An interesting chemical variation of the PGA backbone during the contact period of the reaction mixture with lipase has been introduced by the Hutcheon and Saleem groups.
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PMC9727330
Therefore, this study demonstrates that NNDAsp, an Asp analog, can disrupt colon cancer cell proliferation without affecting the normal human colon mucosal epithelial cell line.
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PMC9429973
Interestingly, the number of CD34CD38 leukemic cells in AML1 was hardly affected by chemotherapy, whereas treatment significantly reduced the number of these cells in AML2 (Figure 1B bottom), indicating that leukemic CD34CD38 cells residing within different patients have a heterogeneous response to polychemotherapy.
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PMC8973725
The quantitative real-time polymerase chain reaction (qRT-PCR) was carried out using the SYBR® Premix Dimer Eraser Kit (TaKaRa, Dalian, China) on an Applied Biosystems 7,500 Real-Time PCR System.
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PMC9429973
Importantly, the combination therapy of vamifeport and BTs resulted in lower proportion of immature erythrocytes and higher percentage of mature erythrocytes as compared to either treatment alone, suggesting additive effects of vamifeport and repeated BTs.
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PMC11216402
Normalization and the DE gene analysis were performed similar to what described above (FDR < 0.01, log2FC > 2), in which 982 and 5611 genes are upregulated in Mes-like GC and ENCODE fibroblast samples, respectively.
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PMC9429973
After multivariable Cox analysis including previous anti-SARS-Cov-2 vaccine, need for hospitalization, age≥70 and male sex, OS to COVID-19 was significantly improved in pts who had previously received anti-SARS-Cov-2 vaccine (HR=0.10, p=0.02) (Fig.1), in pts with COVID-19 not requiring hospitalization (HR=0.19, p=0.03) and in patients <70 yrs (HR=0.38, p=0.03).
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PMC11695623
H–J) Relationship between NDC1, DEPDC1, and CENPA expression and patient OS in the TCGA-LUAD dataset. *
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PMC11650848
We discovered a single-nucleotide polymorphism (SNP) within the ZFP57 promoter/DMR that dictates methylation of the surrounding region.
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PMC9429973
Image: Summary/Conclusion: Single doses of nipocalimab, when administered at doses up to 60 mg/kg and infusion rates up to 4 mg/kg/min were safe and well-tolerated in healthy adults.
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PMC8526701
E WT and PUMA-KO GIST-882 cells were treated with 0.5 μM GSK602 for 24 h. Apoptosis was analyzed by fragment nuclei assay.
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PMC11453018
Cont” refers to untreated cells, “siCont” indicates cells treated with scramble siRNA, and “siCBP/P300” refers to cells treated with siRNA targeting both CBP and P300.
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PMC11633763
To confirm our hypothesis, we examined HK2 protein and mRNA expression in osteosarcoma cells following USP22 knockdown and overexpression.
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PMC11138140
Detailed information regarding the statistical methods employed and the sample sizes assessed can be found in the respective figure legends.
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PMC11548041
The PLD01-EpEX monomer complex was stable throughout the MD simulation, as indicated by maintaining a magnitude RMSD x ≤ 4 Å and achieving a highly stable conformation at ~100 ns (Figure 2A).
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PMC10956161
Diagnostic efficacy of the peroxiredoxin 6 (PRDX6) gene in lung adenocarcinoma (LUAD) patients: (a) overall cohort; and in those analysed according to smoking history (b), sex (c) and race (d).
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PMC9429973
The median age of patients at the time of collection was 63 years.
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PMC11787651
Histone post-translational modifications (PTMs) regulate gene expression patterns through epigenetic mechanisms.
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PMC11672617
Jurkat cells were incubated for four hours with the test substances at concentrations corresponding to their 24-h CC50 in these cells, after which they were analyzed by flow cytometry (NovoCyte Flow Cytometry™).
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PMC9581083
Overview of TNRICM101 ingredients and the therapeutic efficacies of each ingredient Lin et al. (2007).
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PMC11792766
The combination of methanol and acetone was preferred over methanol and DMSO, as acetone is less polar than DMSO, covering a wider range of apolar chemicals predicted to be present in FCMs and PPPO.
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PMC11343332
Data are presented as mean standard deviations (n = 3); * when compared to the control blank group, p< 0.05.
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PMC6627640
Alterations in traditional mechanisms of cisplatin sensitivity or resistance in other solid tumors have been generally rejected as explanations for the inherent sensitivity of TGCTs .
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PMC10976516
Mechanisms of OV therapy (A) OVs either naturally or after genetic manipulation selectively multiply in cancerous cells.
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PMC11786156
After 0 h (immediately after treatment with LFA1), 24 h, 48 h, and 72 h, HBL-2 cells were incubated with the cell proliferation reagent WST-1 for 1 h. The OD at 450 nm was measured to quantify the viability of HBL-2.
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PMC7215832
To determine the effect of RX-3117 treatment on p16 expression we exposed SW1573 cells to 1-10 µM RX-3117, which led to re-activation of suppressed p16 (Figure 2D).
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PMC8358176
The following program was executed on a BIO-RAD CFX96 system (Bio-Rad, USA) for PCR amplification: at first, one cycle (95 °C for 15 min) and then 40 cycles (95 °C, 60 °C, and 72 °C for 30 s for each temperature).
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PMC11461833
Figure 2STXBP5 regulated progerin expression. (
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PMC9841531
Intermediate 13 precipitated after stirring for 1 h at room temperature, which was filtered, dried, and used without further purification and characterization.
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PMC9429973
Therapy was well tolerated with no reported treatment-related mortality.
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PMC9386809
In order to determine the optimum reaction conditions, we examined the influence of the temperature, solvent, reaction time, and the amounts of catalyst 2 on a model reaction between p-chlorobenzaldehyde (1 mmol) and indole (2 mmol).
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PMC5811757
As shown in Figure 3, ABCB1 gene expression was considerably downregulated (fold change 0.001) in cells transfected with sgRNAs ABCB1 compared to that in the cells transfected with scramble vector and untransfected control cells (***, P<0.001).
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PMC10729469
This resulted in the deletion of TCRs on more than 95% of Tregs.
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PMC11413393
3PRMT1 knockdown inhibits ccRCC proliferation and overexpression results in MS023 resistance.a Western blot analysis of PRMT1 expression (top) and asymmetric dimethylarginine (aDMA) changes using the ASYM25 antibody (bottom) in 786-0 and RCC 243 cells.
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PMC11476264
To explore the physiological role of FBXO11 and ZEB1 in vivo, we transplanted A549 cells into nude mice (Balb/c-nu/nu) with an immunodeficient system suitable for tumor transplantation and immunology research (Figure 6A).
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PMC9917080
A-172 cells (Human brain glioblastoma cell line) were purchased from ATCC (Manassas, VA, USA) and were grown on round coverslips for 48 h in a CO2-incubator in DMEM medium supplemented with 10% fetal bovine serum until a confluence of 80–95% was achieved.
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PMC11792766
After 24 h of exposure, 50 µL of the exposure medium was collected from each well into another 96‐well plate for the LDH assay.
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PMC11323699
Furthermore, in the CD47 group, a significant increase in CD4 cell (threefold, p = 0.032) and CD8 cell (2.4-fold, p = 0.011) tumor infiltration was observed after NACT (Fig. 3c).
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PMC9429973
This study highlights the need for national-specific plans for effective management strategies and allocation of resources.
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PMC9454178
A Immunoblotting analysis of CDK7 expression after targeting siRNA-mediated CDK7 knockdown in GIST-T1 and GIST-882 cells.
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PMC11718809
Five cDNA libraries were constructed for circRNA-seq to detect circRNA in yak mammary glands.
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PMC11348300
This allows for malignancy detection through reoxygenation time imaging.
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PMC9966931
In the present work, we have also amply demonstrated reliable, cost-effective, and industrially scalable chemical synthesis methods for EO-based hybrids.
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PMC9429973
In addition, we have generated a bone marrow transplant model of MYCN-driven T cell lymphoma, and we performed a thorough characterization of this model using RNA-sequencing and ChIP-sequencing.
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PMC11640476
In detail, the results showed a mean relative repeatability of 4.3% and a mean relative reproducibility of 6.9%.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "detail", ",", "the", "results", "showed", "a", "mean", "relative", "repeatability", "of", "4.3", "%", "and", "a", "mean", "relative", "reproducibility", "of", "6.9", "%", "." ] } ]
PMC4685407
The CRISPR targeting sequence was determined from the BAC clone Cg0031N14, which contained the chromosome O sequence.
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PMC11697065
These included one known ETE monoclonal antibody (mAb1), two known DTE bispecific antibodies (BisAb1 and BisAb2), and a monovalent control for each of the bispecific antibodies (MonoAb1 and MonoAb2, respectively) whose expression levels were unknown (Fig. 1A).
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PMC7723249
RNA was extracted from cell lysate using Directzole RNA extraction kit (Zymo Research).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "was", "extracted", "from", "cell", "lysate", "using", "Directzole", "RNA", "extraction", "kit", "(", "Zymo", "Research", ")", "." ] } ]
PMC11310713
The combination of progesterone with estrogen is used to prevent the occurrence of endometrial carcinoma in women with an intact uterus .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "of", "progesterone", "with", "estrogen", "is", "used", "to", "prevent", "the", "occurrence", "of", "endometrial", "carcinoma", "in", "women", "with", "an", "intact", "uterus", "." ] } ]
PMC9388315
Because MIR317 causes the activation of glutaminase GLS1, which helps to reactivate mTOR by hydrolyzing glutamine.
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PMC11467964
Furthermore, the box plot indicated marked differences in gene expression levels between two gene clusters (Figure 4E).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "box", "plot", "indicated", "marked", "differences", "in", "gene", "expression", "levels", "between", "two", "gene", "clusters", "(", "Figure", "4E", ")", "." ] } ]
PMC11762280
In human primary keratinocytes, accompanied with UVB-induced upregulation of N-GSDMD, cleaved-PARP, cleaved caspase-3, and p-MLKL, the level of ZBP1 was also elevated (Fig. 6B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "human", "primary", "keratinocytes", ",", "accompanied", "with", "UVB-induced", "upregulation", "of", "N-GSDMD", ",", "cleaved-PARP", ",", "cleaved", "caspase-3", ",", "and", "p-MLKL", ",", "the", "level", "of", "ZBP1", "was", "also", "elevated", "(", "Fig.", "6B", ")", "." ] } ]
PMC9429973
There were no statistically significant differences in OS by the route of AZA administration, insurance category, county metropolitan status, or county poverty level.
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PMC11411004
On the day before transfection, the cells were seeded at a concentration of 300,000 per milliliter, and the liposome transfection process was started when the cells had grown to 70% coverage on the second day: 50 μL basal DMEM/F12 medium and 0.8 μg ADM plasmid were gently mixed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "day", "before", "transfection", ",", "the", "cells", "were", "seeded", "at", "a", "concentration", "of", "300,000", "per", "milliliter", ",", "and", "the", "liposome", "transfection", "process", "was", "started", "when", "the", "cells", "had", "grown", "to", "70", "%", "coverage", "on", "the", "second", "day", ":", "50", "μL", "basal", "DMEM/F12", "medium", "and", "0.8", "μg", "ADM", "plasmid", "were", "gently", "mixed", "." ] } ]
PMC9429973
The results were consistent for each testing method.
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PMC9429973
Safety was manageable, however, more data on additional patients and longer observation time are needed to evaluate the efficacy of KO7 CAR-T products further.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Safety", "was", "manageable", ",", "however", ",", "more", "data", "on", "additional", "patients", "and", "longer", "observation", "time", "are", "needed", "to", "evaluate", "the", "efficacy", "of", "KO7", "CAR-T", "products", "further", "." ] } ]
PMC11535726
Based on our phylogeny, species with sporidesmium-like and dendryphiopsis-like morphs do constitute distinct clades.
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PMC8345486
After reaction completion, the solvents were evaporated and the crude products were purified silica gel column chromatography.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "reaction", "completion", ",", "the", "solvents", "were", "evaporated", "and", "the", "crude", "products", "were", "purified", "silica", "gel", "column", "chromatography", "." ] } ]
PMC6468656
In addition to the modulation of cancer invasion, the ghrelin-ghrelin receptor signaling axis is pivotal in regulating cell motility and cell-cell adhesion, which led to cancer metastasis in many types of cancer .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "the", "modulation", "of", "cancer", "invasion", ",", "the", "ghrelin-ghrelin", "receptor", "signaling", "axis", "is", "pivotal", "in", "regulating", "cell", "motility", "and", "cell-cell", "adhesion", ",", "which", "led", "to", "cancer", "metastasis", "in", "many", "types", "of", "cancer", "." ] } ]
PMC10093184
Increased levels of ERBB2 were found in canine osteosarcoma cell lines and tissue samples compared with normal bone .
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PMC10421378
Additionally, the development of new tissue and organ models makes it possible to better represent the structural architecture of the intestinal tissues using 3d designs and allows for obtaining a multilayered system incorporating all types of cells found in the intestines.
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PMC8010066
Biofilm and planktonic co-culture of P. aeruginosa and S. aureus were performed in the A549 cell line.
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PMC11755467
Since Enoxacin is a proven anti-cancer drug, we intended to rule out whether the treatment eventually flawed its anti-HIV-1 effect in CEM-SS cells by reducing cell viability.
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PMC8041314
The same accounts for a compound that was classified as “inactive” in one assay and associated with a definite IC50 value in another assay.
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PMC11787355
A 10-µl Hamilton micro-syringe driven by a dine step stereotactic device (Stoelting) was employed for injection.
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PMC11665555
This highly heterogeneous disease is further characterized into luminal and basal molecular subtypes with invasive and noninvasive lesions that affect clinical care decisions (3).
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PMC11767817
One of the well-known biochemical hallmarks of apoptosis is the generation of oligo- and mononucleosomes due to chromatin cleavage by endonucleases .
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PMC11772585
Glucose uptake was assessed using the Glucose Assay Kit (A154-2-1, Nanjing JianCheng Bioengineering Institute).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glucose", "uptake", "was", "assessed", "using", "the", "Glucose", "Assay", "Kit", "(", "A154", "-", "2", "-", "1", ",", "Nanjing", "JianCheng", "Bioengineering", "Institute", ")", "." ] } ]
PMC9429973
Image: Summary/Conclusion: This first prospective study of real-life current SOC in triple-class exposed patients with RRMM reported limited gains in HRQoL, most notably in pain symptoms.
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PMC11708541
A novel set of kojic acid derivatives conjugated to amino pyridine intended to investigate its tyrosinase-inhibiting potential was presented.
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PMC7338939
After tumor development (about 1 week), mice were classified randomly in four groups.
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PMC9429973
While previous studies have described several features of der(1;7), the understanding of der(1;7)+ MDS/AML is largely limited due to their small study size.
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PMC11591794
Complementary DNA synthesis was performed to enable the RNAs obtained after the synchronization process to be amplified by PCR.
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PMC11551844
FTIR spectroscopy was performed using a Bruker Alpha ATR Infrared Spectrometer, where 32 scans were collected.
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PMC9429973
20 patients received no iron support (group B).
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PMC9812014
Research articles, Review articles, and Patents mentioning the antiviral mode of alkaloids from 1960 till mid 2022 were accessed from all of these sources and then subjected to further analysis.
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PMC5311252
Patients were split into two groups using the two main clusters defined by the hierarchical clustering based on the oncomotif-miRNA signature.
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PMC6617630
a–f WT-MYC (U2932), DHL (LY1), and THL (Val) DLBCL cell lines were treated with I-BET alone, SAHA alone, and combination of both and proliferation and survival analyzed by H-thymidine incorporation and annexin/PI, respectively.
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PMC9429973
In total, the disease progression occurred in 18% (45/249).
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