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PMC11720808
All animal experiments were performed in accordance with the welfare and ethics guidelines set by the Ethics Committee of the Affiliated Hospital of Jining Medical University for the care and use of animals, following a protocol reviewed and approved by the Ethics Committee of the Affiliated Hospital of Jining Medical University (Approval Number: 2022–11-B001).
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PMC7452526
Then the resulting supernatant was filtered by Whatman No.1 filter paper and stored into a dark container at refrigerator temperature.
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PMC10891340
The CHv strain used in this study is a virulent DPV strain that has been isolated and identified at research center.
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PMC11610461
and “****” indicate p < 0.05, p < 0.01, p < 0.001 and p < 0.0001, respectively.
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PMC11760643
contamination using the Myco Alert Mycoplasma Detection Kit (Lonza, Switzerland) as per the manufacturer's instructions and were found to be routinely negative.
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PMC11653533
Juice of stem barks of F. auriculata is a folk remedy in Nepal ordinarily used to treat loose bowels, dysentery, cuts, and wounds (Shilpakar, 2009).
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PMC9812014
NDV is a zoonotic virus that infects all species of birds and is a member of the paramyxoviridae family.
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PMC11240571
In contrast, irradiation to 143B tumor cells did not show significant histological upregulation of cellular PD-L1 (Figure 5B).
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PMC11750712
Circulating engraftment might be improved by administration of more intensive lymphodepletion and improving manufacture by, for example, shortening the process, and/or adding dasatinib to the AUTO4 cells during the manufacture expansion phase.
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PMC9872547
Equal volumes of protein samples (40 μg) were disrupted at 90°C for 5 min, subjected to SDS-PAGE, and transferred to polyvinylidene difluoride (PVDF) filter membranes.
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PMC11461833
Therefore, decreasing STXBP5 expression is a potential new therapeutic strategy for treating ageing-related phenotypes in patients with HGPS.Hutchinson-Gilford progeria syndrome (HGPS) was first described by Drs.
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PMC9275501
A summary of the researches of polymer micelles used to co-deliver chemotherapy drugs and natural active ingredients is shown in Table 6.
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PMC11750712
Median with 95% CI calculated from PROC LIFETEST output.
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PMC11395280
Downstream of CCR7 binding to a ligand, we have shown that CCL19 and CCL21 activate phospholipase Cγ1 (PLCγ1) , which can mediate cleavage of phosphatidylinositol (4,5)-bisphosphate (PIP2), leading to the production of IP3 and the resultant mobilization of Ca from intracellular stores in lymphocytes .
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PMC9429973
Methods: We analyzed the association between GFI1-36N and chromosomal aberrations in human AML samples.
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PMC11401350
In agreement, spleens from the CAR group contained twofold higher percentages of CD8 T cells than the control group, while the CD4 + T cells followed an inverse pattern meaning significant CD4 + T cell elimination for the CAR treated group (Fig. 5E).
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PMC8996378
Their effects on the reversal of MDR were examined on mouse lymphoma cells.
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PMC11736898
Gene expression was analyzed by quantitative PCR, and expression levels were normalized to expression in control, untreated cells of the same type, normal or keloid, as indicated (white, open bars).
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PMC9429973
Real-world equivalent (based on EHR only) of these endpoints were also derived.
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PMC5386478
It is therefore necessary to acquire new insights into the pathobiology of this disease to improve diagnosis and provide targets for more effective therapeutic strategies.
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PMC6617630
PCR was performed according to the HotStar Taq Master Mix kit instructions.
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PMC11467964
Kaplan–Meier curves for OS of two distinct molecular subtypes (log‐rank tests, p = .153). (
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PMC9429973
Results: Increased glycolysis, which was characterized by elevated PFKFB3, as well as higher rates of glucose consumption and lactate production in aGvHD T cells.
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PMC10291556
COX activity was determined with a COX Activity Assay Kit (Abcam).
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PMC11782780
WB demonstrated that oe-EBF3 considerably repressed HK2, PFKP, and PKM2 levels in MDA-MB-231 cells (Fig. 3B).
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PMC3019555
Vinblastine and MG-132 were obtained from EMD, and paclitaxel was obtained from Sigma-Aldrich.
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PMC10291556
The cells were incubated for 30 min at 37 °C and then harvested using trypsin.
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PMC9429973
Treatment with the RCHOP regimen is standard of care and can be administered either every 3 weeks (RCHOP-21) or dose-dense biweekly (RCHOP-14).
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PMC10607604
On the other hand, wild-type KURAMOCHI cells expressed less PARP than Kura-B1 (KO for PTPN13) cells, and we also observed a rapid PARP degradation in wild-type cells (supplementary Figure S5).
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PMC11514418
As revealed in studies on its primary structure, the main chain has a 1,3-linked-β-D-Gal residue, and its branches contain multiple monosaccharide residues, mainly comprising β-Glc, 1,6-linked-α-Gal, 1,5-linked-β-Xyl, 1,4-linked-β-Gal, β-D-Gal, 1,2-linked-α-Rha, and 1,2,4-linked-α-Rha.
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PMC11024707
RPE solution (0.5 ml) was added to the spin column, and it was centrifuged at 12,000 g for 30 seconds.
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PMC11790599
The plate was cultured at 37°C and 5% CO2 for various time points or concentrations, after which, histocultures were harvested for the desired downstream analysis (Centenera et al., 2022; Holliday et al., 2013).
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PMC11406030
Most patients had equivalent nuclear and cytoplasmic staining intensities (69.5%), while 22.3% had stronger nuclear than cytoplasmic staining, and only 8.1% exhibited stronger cytoplasmic staining than nuclear staining.
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PMC9910796
Interestingly, immunogold labeling within the virus particles was mostly detected in close proximity to the interface between the viral core shell and the inner envelope (Fig 1F, lower panels) in both immature (left) and mature (middle) particles at the assembly sites as well as in mature budding particles at the PM (right).
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PMC11715644
When cells encounter an interface between soft and stiff regions, they undergo ‘durotaxis’ and quickly migrate into the stiffer side due to higher forces.
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PMC9429973
Seventy-seven patients were enrolled from January 1, 2008 to November 31, 2019.
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PMC11467964
In comparison, cluster B was enriched significantly in some metabolism pathways, such as one carbon pool by folate, butanoate metabolism, and propanoate metabolism (Figure 3A, Supporting Information S2: Table S6).
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PMC11711127
This supports a consensus that prolonged contact tends towards T cell activation, regardless of contact phenotype, i.e. synapse vs. kinapse, provided there is sufficient recruitment of signalling machinery (52).
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PMC11787355
i and j were measured with LDH release, and 1 unit equals to 75 ×10 cells in.
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PMC11718031
This suggests that lactate and ammonia accumulation in these cases might influence productivity and peak viable cell count.
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PMC8270637
Flow cytometry was used to detect the expression of CTLA-4 on T cells. (
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PMC11190538
Due to the limited growth and activity of Lactobacillus over the 21-day storage period, neither the pH of the control yoghurt nor the pH of the C-phycocyanin-enriched yoghurt decreased considerably.
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PMC10571053
Bottom row: Cells were incubated with rhodamine 123 (0.5 µg/mL) with or without 10 µM valspodar for 30 min, after which media was removed and replaced with substrate-free medium continuing with or without inhibitor for an additional 1 h. Cell autofluorescence (control) is denoted by red histograms, rhodamine efflux by blue histograms, and cells with rhodamine and inhibitor are denoted by orange histograms.
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PMC11802929
d For each peptide, conventional anchor positions (R2, R9) and non-anchor residues are assigned.
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PMC10158546
The lack of PrP conversion we observed in this paradigm is also counterintuitive, given the capacity of ReN cells to replicate misfolded proteins in models of Alzheimer’s disease [25–28].
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PMC9712534
Given the role of TOP2B in neuronal gene expression, the H58Y substitution may perturb the gene expression patterns during neural development, which may eventually lead to autism.
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PMC11283030
The spindle-shaped and less scattering cell morphology was observed after transfection with siRNA targeting ACLY (Fig. 6a).Fig.
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PMC6181431
mTOR is a serine threonine kinase which occurs in cells in two large multi-component complexes termed mTORC1 and mTORC2 .
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PMC11026382
Together, these two rounds of PCR yielded a final product of size: 315 bp (SL1), 308 bp (SL2), 298 bp (SL3), 304 bp (SL4).
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PMC11317131
Each chemostat was maintained at 200–250 ml at a OD600 of 0.3–0.7 (flow rate ∼3–5 ml/min) and replaced with fresh arabinose sensitive host cells every 2 days.
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PMC11407042
Set up at least triplicate wells with untreated cells to serve as a negative control.24.Culture at 37°C with 5% CO2 and 95% humidity for 4 h.Note: For the first experiment, co-culture at different time points is recommended.
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PMC8409415
Correlation between CD70 expression levels and clinicopathological characteristics in serous ovarian carcinoma CD70 high CD70 low/negative Median (IQR) or number (percentage per column) is shown.
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PMC6337547
The results demonstrated that caffeic acids have beneficial effects on aberrant platelet activation-related diseases.
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PMC11047729
This substance acts as an antioxidant and has immunomodulatory, anti-cancerous, anti-inflammatory, and hepatoprotective effects .
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PMC9429973
Twelve patients (64%) were refractory to last treatment.
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PMC11748335
In embryonic stem cells, over 85% of H3K27me3-marked promoters are poised promoters, containing both H3K4me3 and H3K27me3 marks .
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PMC10178190
Intestinally, CM derived from MSC grown as a monolayer was potent in conferring platinum chemoresistance to OV-90 cells (Figure 1C), while the same CM was less effective in promoting platinum chemoresistance to A2780 or A2780CisR cells (Figure 1A,B).
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PMC11502066
About one third of all FDA-approved drugs indeed interact with one or more GPCRs, suggesting that this class of receptors possesses an enormous clinical relevance .
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PMC9429973
However, upfront resistance and relapse remain major obstacles.
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PMC11472639
Due to an unavailable blood sample within 3-min after completion of the exercise bout, n = 1 SMM data were excluded from subsequent analysis.
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PMC11772449
Different from other ways of death, in the physiological state, the cell itself has a background autophagy process, also known as basic autophagy, which is a normal physiological phenomenon.
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PMC11752740
This finding is consistent with research by Clemens et al., which demonstrated that CFZ similarly downregulated MDR1 expression in other cancer cell lines, highlighting its potential to mitigate multidrug resistance in tumor cells .
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PMC7342409
Abnormal or non-uniform variance data were used for statistics in the rank sum test.
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PMC10589262
Moreover, previous studies have suggested that sustained activation of ATF6 is a prosurvival mechanism in various cancer types such as melanoma, glioblastoma, and hepatocellular carcinoma [35–37].
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PMC11502962
Immunofluorescence showed that MIF expression is present both inside and outside GIST cells. (
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PMC11476837
In the case of ML-385 at 50 µM, we observed 2.2-fold increase (p < 0.001).
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PMC6889484
RRE, Rev response element; Ψ, HIV-1 RNA packaging signal; cPPT, central polypurine tract. (
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PMC9592219
This study was approved by the Ethical Review Committee of Shanxi Bethune Hospital (no.: SBQLL-2020-038).
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PMC10899471
In vitro and in vivo experiments revealed that miR-939-3p enhanced sarcoma proliferation through suppressing BATF2 expression via binding to its 3’ UTR.
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PMC10988808
The expression of CCDC25, a notably underexpressed gene in many tumors, has been understudied in ccRCC.
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PMC11678841
GA, differently from α-TOH, significantly reduced the C. albicans-induced activation of p38-SAPK while increasing pro-survival MAPK ERK1/2 activity.
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PMC4695073
We also performed subgroup survival analysis to evaluate the value of XPA expression on prognostic prediction (OS and PFS) of patient subgroups stratified by gender, age, T classification, N classification, VCA-IgA, EA-IgA and treatment strategy.
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PMC10747160
To do so, we produced N-labeled WT-Grft and Q-Grft (as described in the Materials and Methods Section 2.2 above) and then assessed both proteins by NMR HSQC (Figure 1D).
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PMC11680562
The gels were deposited onto aluminum foil and desiccated under vacuum conditions to produce a PXFCu gel thin film.
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PMC11750161
Plasmid DNA (160 μg) and FreeStyle MAX reagent (160 μL) were mixed gently with 1.2 mL of OptiPRO serum-free medium and media samples were mixed and incubated for 5 min at RT.
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PMC10820104
Most notably, our analysis of the fungal genome of A. chevalieri, which is described for the first time, revealed the ability of this fungus to synthesize prenyltransferases as tailoring enzymes involved in the production of prenylated compounds, as evidenced by the isolation of different prenylated indole DKPs from the fungus.
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PMC9429973
Publically available scRNA-seq data from 5 healthy donors (HD) were also integrated as controls.
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PMC9429973
KB predictions 3 years after diagnosis were retrospectively calculated by using the adapted transplant strategy and compared to the observed outcomes using receiver operating characteristics (ROC) curves.
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PMC7757104
After adhesion, the cells were exposed to 10, 20, 40, 60 and 100 µM CDDP or drug-free complete medium for 24 or 96 h. Drug-free medium was added to the control wells.
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PMC11470999
Luciferase‐expressing brain seeking B16 cell line B16Br‐luc was obtained via the following procedure.
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PMC11803149
This revealed that adoptive transfer of young OT-I TCR-T cells significantly inhibited tumor growth in young mice, whereas aged OT-I TCR-T cells did not affect tumor growth in aged mice ( Figure 3A ), suggesting that aging reduces anti-tumor activity of CD8 TCR-T cells in vivo.
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PMC5874706
All chemicals and phosphate buffer solution were purchased from Acros Organics or Sigma Aldrich and used without further purification.
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PMC11721587
The RNA transcripts were extracted with TRIzol and chloroform and then redissolved in ribonuclease-free water and treated with 10 U of DNase I at 37°C for another 20 min.
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PMC7504302
Similarly, subcutaneous tumors formed by the inoculation of the MPM cell line expressing sALCAM resulted in significantly prolonged survival in mice, offering therapeutic utility of this cell adhesion molecule in MPM .
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PMC6190245
Co-administration of F. gummosa and radiotherapy, showed that this plant at non-toxic low doses, could result in almost 5-fold increment in sensitization of cells towards radiation-induced toxicity.
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PMC11471176
IBM SPSS Statistics 26.0 was used to graph data and generate error bars with 95 % confidence intervals (95 % CI) and/or standard errors of the mean (SEM).
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PMC11721587
For protein purification using the baculovirus system, Sf9 cells were infected with corresponding baculovirus at the density of 1 to 2 × 10/ml, and infected cells were collected 2 days after the infection.
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PMC11707832
Additionally, the novel insights presented in this review may aid in understanding the role of MAN2B1 in immune cells, thereby paving the way for targeted therapeutic interventions in immune-related disorders.
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PMC11306331
A Schematic of approach.
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PMC2362953
Transfected cells generated IL-2 in the range of 330–1800 pg 10 cells 24 h with a mean of 836 pg 10 cells 24 h. Ten patients received 1–5 intravenous infusions of IL-2-transfected CIK cells; five infusions with transfected CIK cells were given.
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PMC11747467
The concentration of the supernatant was determined using the bicinchoninic acid assay (BCA) (Solarbio, Beijing).
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PMC11612315
The remaining currents between the arrows were CAP-induced currents inhibited by BCTC or exendin 9–39.
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PMC11615828
Moreover, FKBP tagging on VOIs did not affect their motility as evidenced by the similar velocities of VOIs with and without FKBP tagging (Figure S1g,h and Video S1, Supporting Information).
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PMC7602170
In GISTs, the activation mutation of the upstream c-KIT and PDGFRA is the initial mechanism of the PI3K/AKT/mTOR signal activation .
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PMC11794588
Lupeol’s apoptosis-inducing activity in A549 cells is key to its anticancer effects.
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PMC11634027
Conversely, complete ICD deletion, or deletion of just the D motif, resulted in a completely penetrant mis-looped phenotype like that of ds mutants (Fig. 8C,E,I).
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PMC6312945
The expression levels of miR-101 and miR-345 in the MHCC97-L pSUPER.neo-miR-101 and MHCC97-L pSUPER.neo-miR-345 groups were significantly higher than those in the MHCC97-L pSUPER.neo-101 and MHCC97-L pSUPER.neo-345 groups (P<0.05) (Figs. 1 and 2).
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PMC9429973
S. Colucci, V. Venturi, F. Nicole, D. Jové Solavera, M. Zimon, P. Richter-Pechanska, G. Hernandez, S. Unal, F. Gumruk, A. Diaz-Conradi, L. Romero-Cortadellas, X. Ferrer-Cortès, M. Olivella, M. Erlacher, C. Niemeyer, T. Wiesel, R. Pepperkok, M. D. Fleming, A. E. Kulozik, M. Sanchez, M. U. Muckenthaler Department of Pediatric Oncology, Hematology, and Immunology, Heidelberg University; Molecular Medicine Partnership Unit (MMPU), Heidelberg, Germany; Department of Basic Sciences, Iron metabolism: Regulation and Diseases, Universitat Internacional de Catalunya (UIC), Sant Cugat del Vallès, Spain; European Molecular Biology Laboratory (EMBL), Heidelberg, Germany; BloodGenetics S.L. Diagnostics in Inherited Blood Diseases, Esplugues de Llobregat, Spain; Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey; Hospital de Nens de Barcelona, Barcelona; Biosciences Department, Faculty of Sciences and Technology (FCT), University of Vic - Central University of Catalonia, Vic, Spain; Department of Pediatrics and Adolescent Medicine, Medical Center, University of Freiburg, Freiburg; Vestische Kinder- und Jugendklinik Datteln, University Witten/Herdecke, Datteln, Germany; Department of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, United States of America Background: Anemia affects ~25% of the world population and is frequently caused by iron deficiency as a consequence of malnutrition or inflammation.
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PMC9429973
For the CCPS, the percentages of low-, intermediate-, and high-risk patients were 64.9%, 20.5%, and 14.6%, respectively (Table 1).
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PMC10898159
The ATP-binding pocket, encoded by exon 13 and 14, whose mutations directly interfere with IM binding, or the activation ring, where mutations can stabilize the KIT's active conformation .
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