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OTAR3088
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PMC11206251
Five duplicate wells were set for each concentration.
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PMC11770130
The metabolism of ceramide is extremely complicated, as these lipids can be synthesized and degraded by a large collection of enzymes in various pathways.
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PMC11352311
Specifically, the addition of 100 μM, 150 μM, and 200μM esculin reduced the closure rate of 786-O to 77.21 ± 1.52%, 61.89 ± 3.52%, and 23.08 ± 2.45%, respectively (Figure 4C).
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PMC11720808
Quantification of OS cell proliferation shown in (C). (
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PMC11335267
No differences in food intake were observed during the first 30 min of food availability (Fig. 8B), but then Alx3-deficient mice ceased eating for approximately two hours, whereas wild type mice went on feeding so that cumulative food intake increased progressively during this period (Fig. 8B).
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PMC11683240
For this, the server Mutabind2 was used following three different approaches (1), mutate all residues for alanine at the same time (2), separate the residues in three specific clusters and mutate all the residues from each cluster; cluster 1: E75, E78, T309, K310, and S313; cluster 2: K174, E175, L176, D177, R178, and D179; and, cluster 3: Q44, S45, S301, and Q305.
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PMC11476222
These results are consistent with findings previously reported by Eggers et al., 2016, where the percent recovery for the Folch method was also above 90% .
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PMC11686380
These abnormalities are likely to lead to a haploinsufficiency condition similar to our case.
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PMC10366908
EMab-300 recognized CHO/mEGFR cells dose-dependently at 10, 1, 0.1, and 0.01 μg/mL (Figure 2A).
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PMC11680578
Statistical analyses were conducted using GraphPad Prism version 7.0.
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PMC10165258
non-significant; ∗: .
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PMC9545474
These observations are consistent with the proposed MoA for these complexes, which is based on the disruption of the cellular redox balance.
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PMC11321678
In addition, scATAC‐seq profiles show periodic fragment length distributions and enrichment of fragments around TSS (Figure S1A, Supporting Information).
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PMC9847912
Approximately 18 hours after the addition of DNA, the supernatant in each well was removed and replaced with 2 ml of fresh, complete DMEM.
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PMC10578720
Globally, an estimated 250 million individuals are chronically infected with HBV, and about 1 million individuals die each year from HBV-related liver disease.
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PMC11502066
These findings are of great interest for further development of novel agents for colon cancer therapy.
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PMC7823217
Fig. B is reproduced from Ref.
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PMC11764090
Plants have evolved various strategies to cope with cold stress.
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PMC11377827
Representative of three biological replicates. (
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PMC11300639
Ring finger protein 26 (RNF26) is an E3 ubiquitin ligase belonging to the RING finger domain protein family.
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PMC9429973
Dose escalation continues as an MTD has not yet been reached in any dose-escalation cohort.
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PMC5941560
The Jurkat cell line has an extensive history as a model of T cell signaling.
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PMC11799620
Briefly, the cells (1×10 cells/ml) seeded in a flask of 75 cm.
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PMC11422497
Schematic representation of potential binding sites between miR-494-3p and KIT. (
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PMC11787355
N(Tumor only)=4, N(Flu TCR-T cell)=8, and N(PTPRZ1 TCR-T cell)=7.
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PMC11670407
Taken together, our results indicate that OTULIN knockdown facilitates mitochondrial pathway apoptosis, but not ferroptosis, in cisplatin-treated osteosarcoma cells.
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PMC11467964
We further investigated the distribution of somatic mutations and found that TP53 and ATRX were the most mutated genes in the high‐risk group.
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PMC11723947
i, j Percentage of CD73FR4 (i) or Foxp3 (j) cells among WT or HP1α KO TCR Vβ6CD4 T cells, as determined in the spleen 21 days after engraftment.
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PMC11684821
The conservation of TRAJ42 use across all donors suggests that these T cells respond to the same or similar MR1-restricted ligand.
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PMC11474209
This increased response of mtDNA to oxidative lesions could either be due to the vicinity of the mitochondrial membrane region where ROS are produced or because of the asymmetric replication process of mtDNA.
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PMC5874706
This demonstrated that the MTT assay worked properly for the determination of cell viability of A427 cells.
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PMC6133382
Catalog Number 12149).
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PMC8633974
Macrophages are ubiquitous as they are found in all lymphoid and non-lymphoid tissues and contribute both to cell homeostasis while serving as reservoirs for replication competent HIV-1 .
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PMC11013014
4-(2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)acetyl)-N-(4-fluorophenyl)piperazine-1-carboxamide (18).
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PMC10297204
Macroscopically, most mice had recurrence within four weeks after the operation, and only one mouse had recurrence after four weeks (Figure 5).
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PMC11748618
While not statistically significant, rs7525622-G-A had the same direction of effect as GTEx tissues in the MESA (β = 0.056, FDR ≥ 0.19) and AFGR cohort (β = 0.19, p ≤ 0.0042); suggesting that larger sample sizes are necessary for concluding an effect in these cell types.
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PMC11770199
The area outlined by the black dashed line indicated the unfolded syncytia, and those outlined by the red dashed line indicated the shape of shrunk syncytia. (
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PMC10547921
Agensys recently introduced the azide group to the P2 and P4 subunits, resulting in a compound 23 with an IC50 of 0.057 nmol/L in MOLM13 cells.
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PMC11055323
To test this hypothesis, we analyzed several candidate biomacromolecular complexes like BRG1/BAF we previously reported .
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PMC11591038
These transgenic mice overexpress the human 4R/2N tau isoform bearing the P301L mutation under the control of the neuron-specific murine Thy1 promoter with an accumulation of hyperphosphorylated tau, which serves as a transgenic model for AD and frontotemporal dementia (FTD).
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PMC9429973
28 person-hours of interview material was analysed using pre-established criteria.
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PMC9684669
ABCB1 Western blot analysis in MDR cells treated with the indicated terfenadine (Ter) concentration.
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PMC11585994
Peripheral blood (PB) samples from healthy individuals (HIs) and bone marrow (BM) samples from T-ALL patients were obtained from the First Affiliated Hospital of Jinan University.
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PMC11377827
Volcano plots of differential mRNA expression in control 1 versus 21% oxygen (left), or HIF1β KO cells compared with control cells in 1% oxygen (right).
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PMC5839394
Cells were seeded at a density of 200, 400 and 800 cells in 6-well plates.
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PMC10440586
Gene set enrichment analysis (GSEA) was performed using the “clusterProfiler” R package .
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PMC11188874
The HTS also detected known proteasome inhibitors, for example, bortezomib and carfilzomib, as well as agents that previously not been shown to inhibit proteasomes (Supplementary Table S2; Supplementary Fig. S4B).
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PMC10976516
In a preclinical experiment using athymic mice implanted with lung cancer, Chai et al. showed that a reverse genetics system based on the oncolytic NDV D90 strain (rNDV-GFP, recombinant NDV carrying an enhanced green fluorescent protein gene), as well as the parental D90 virus, significantly suppressed body weight loss and tumor growth (Table 2).
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PMC11461874
The cells were treated with MG132, and DBP proteins were immunoprecipitated and subjected to immunoblotting with an anti-HA antibody to detect ubiquitinated DBP.
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PMC9712534
A small area of the nucleus (shown with a white arrow) was photobleached, and fluorescence images were captured at the indicated time points. (
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PMC11247842
Before meta-analysis, we performed the following quality control on summary statistics from each partner in order to check inconsistencies, for example, to identify problems with allele frequencies or strand, level of breed stratification (lambda values) etc.
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PMC11627398
Cuproptosis is a new form of cell death that is triggered by copper overload.
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PMC10748106
It is noteworthy that the most cytotoxic iridoids (Figure 3A,B) exhibit a higher electrostatic distribution in the aldehydic substituent at C4, which also features a hydroxyl at C8.
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PMC4270159
Repeat independently two additional times.
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PMC9429973
Patient characteristics were assessed at T0.
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PMC11533140
Apoptosis was evaluated using the One-Step TUNEL Apoptosis Assay Kit (FITC) (cat.
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PMC11400680
The first step, the prompt generator, aims to detect all possible locations of cells and nuclei and return the detected bounding boxes as prompts.
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PMC11429241
This study aims to address the current knowledge gap in cell culture development by exploring cancer cell spheroid formation on 3D scaffolds printed via TPP.
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PMC9429973
The median age at diagnosis was 53 years (range 23-79) and 54 (37%) were male.
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PMC10440586
Each column represents a sample in the TCGA dataset.
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PMC11394730
Key enzymes involved in glycolysis and glucose uptake are inhibited by QUE’s metabolic effect on cancer through disruption of the PI3K/Akt/mTOR pathways.
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PMC11185260
N = 4–5/group.
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PMC6835428
Thus, PCL is often combined with PEI and/or PEG.
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PMC9429973
Aims: We evaluated the efficacy and safety/tolerability of gilteritinib vs SC in Asian pts with R/R FLT3 AML after first-line therapy.
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PMC10154881
We observed that rMV‐SLAMblind cancer therapy elicited the activation of NK cells, CD4 T cells, and tumor antigen‐specific CD8 T cells.
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PMC7081114
KIF21B plays an important role in HCC progression and may be a potential diagnostic and prognostic marker for HCC.
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PMC11224206
Uniquely, in the preimplantation embryo, while the nuclear material is duplicated during the cleavages of the zygote, the cellular contents (including the mitochondria) are not.
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PMC11714165
Additionally, the zeta potential and hydrodynamic size of the assembled nanoparticles were determined using a Zetasizer Nano ZS90 (Malvern, UK) For the preparation of co‐assembled bone‐targeted fluorous NBD (denoted as DN‐F), NBD‐F (5 mg) and D‐NBD‐F (2.33 mg) were dissolved in methanol (1.2 mL).
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PMC11269933
The phosphorylation level at the CgERK1/2 T187 site increased in C. angulata and decreased in C. gigas.
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PMC9429973
To correct for those differences between methods, we applied a correction factor to the DIHRMS data using the formula (1/Ht)*(1-Ht/1), correcting for the RBC volume (1/Ht) and the plasma volume (1-Ht/1).
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PMC11741906
Whereas SK-OV-3 cell line was grown in McCoy's 5a containing 15 % FBS, 2 mM glutamine, and 0.1 mg/ml of penicillin/streptomycin.
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PMC11334037
OE-IGF2 transfected-GIST-T1 cell lines were injected into the spleen.
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PMC3888431
Two experimental setups of cultivation were done, where cells were exposed to either temperature stress or pH-shift to obtain a broad range of diverse transcripts.
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PMC9429973
Cladribine based regimen in treatment of r/r AML proved to be effective,while the total rate of response is limited.
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PMC11754436
Differential expression of DHRS4-AS1 in human osteoblast cell line and three OS cell lines, *Represent comparison with the hFOB1.19 group. (
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PMC11243198
In GLI-dependent cancer cell models, treatment with BAS 07019774 significantly reduced cell viability in both U87MG and T98G glioblastoma cell lines.
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PMC9250505
For in vitro assays, the statistical differences between the treatment groups were compared using a one-way ANOVA followed by a Tukey’s multiple comparison test.
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PMC11678841
Each year, a significant number of newly discovered natural compounds necessitate systematic efforts to understand their effectiveness and roles as bioactive components or templates for drug development.
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PMC9111184
Cells were passed every 48–72 ​h before reaching confluence.
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PMC11694066
For the analysis, initiation, termination, and cluster patterns of replicative forks were considered to measure fork velocity.
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PMC11711663
A limitation of this study is the difference in clinical distributions between the training and independent set, such as the absence of AJCC stage IV patients in the independent cohort.
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PMC11519788
As for the non-contact co-culture system, UBC cells and U937 cells (ratio 1:1) were cultured in the bottom and upper chamber of 6-well transwell plate (0.4 μm pore size, #3450; Corning, USA) for 96 h before seeding into 96-well plate.
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PMC9429973
Cell viability was analyzed by Resazurin assay after 72 h of incubation.
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PMC11462673
In comparison to the control group, mice subjected to MBZ treatment demonstrated significantly reduced infiltration in the liver, spleen, and bone marrow (Fig. 7D and Fig. S11D).
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PMC9429973
Grade 1-2 ICANS was observed in 3 patients.
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PMC3164356
The samples were treated with DNase in the presence of RNase inhibitor before cDNA synthesis.
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PMC9919300
The goal of the co-administration of the two phytochemicals is represented by the maintenance of the beneficial effects in terms of lipid and ROS reduction together with the cytoprotective effect andrographolide mediated.
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PMC9429973
Here, we report outcomes of patients with HN presenting with COVID19 infection in the setting of high vaccination rates and effective COVID19 therapies, in a population that had low prior exposure to COVID19 due to national border controls and strict isolation measures.
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PMC11764090
Phytohormone signaling mediates abiotic stress responses through multiple mechanisms, including abscisic acid (ABA), gibberellin (GA), jasmonic acid (JA), salicylic acid (SA), brassinosteroids (BR), ethylene (ET), and melatonin (MET).
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PMC11204465
They are highly toxic, mutagenic, carcinogenic, immunosuppressive compounds with severe detrimental effects on the human liver .
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PMC8956657
Our structural data showed that the ORF4b NLS bound to IMPαs using a novel interaction geometry (Fig. 2).
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PMC11657744
Representative immunofluorescence images of cilia from Cep89 wild-type (Cep89) and mutant (Cep89) MEFs.
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PMC11699465
For this purpose, we constructed TMEM199 overexpression and knockdown plasmids.
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PMC11306019
The treatment day was indicated by the black arrow. (
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PMC11612794
3xFLAG-CENP-T or 3xFLAG-CENP-T was expressed in AID-based CENP-T conditional knockdown CENP-C/Dsn1 cells or CENP-C/Dsn1 cells, treated with IAA for 12 h, and added nocodazole.
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PMC8427838
Total number of cases 530.
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PMC9429973
Furthermore, we studied beta-defensin expression in two independent acute GVHD patient cohorts and in mice with acute GVHD.
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PMC5673060
6Comparative assessment of PazR and DasR cells. (
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PMC8701144
However, both AXIN1 and TNKS displayed increased fluorescent staining intensity following G007-LK treatment, thus indicating G007-LK mediated stabilization of AXIN1 and TNKS protein levels (Figure 1, row II, right column) as previously demonstrated upon TNKS inhibition in HEK293 cells .
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PMC11138140
Therefore, we utilized the HOLOMONITOR App Suite software and its Single Cell Tracking module to quantify the three-dimensional optical volumes of individual cardiomyocytes and non-cardiomyocytes at the start (0 h) and finish (24 h) of our live imaging experiments (Figure 1D,E).
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