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PMC11683130
The differentiation of keratinocytes affects the formation of the cornified envelope that is an insoluble protein and lipid structure with barrier functional properties (131, 132).
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PMC9784246
The binding affinity values of the compounds with the active site showed high affinities ranging from −23.6583 to −6.8037 kcal/mol.
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PMC10654497
Lung adenocarcinoma, the most frequent type of lung cancer, is the leading cause of cancer-related deaths worldwide.
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PMC9429973
Flow cytometry was used to detect different myeloid and TBNK cell populations along with Clever-1, HLA-DR, PD-(L)1 and Granzyme B protein expression.
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PMC9105697
We therefore employed library preparation kits that are optimized for challenging cfDNA samples and performed a double target capture of the libraries .
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PMC10048572
Yu et al. conducted a meta-analysis to investigate whether ITH can serve as a valuable prognostic indicator in solid tumors.
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PMC11604015
Because CD7-KO human hematopoietic stem cells (HSCs) permitted normal T cell development and function.
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PMC7887261
To measure the cumulative effect of the rare deleterious variants within the gene, we performed collapsing tests using the CMC and the KBAC tests.
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PMC11730311
Peptide identities and purities were determined by LC–MS on an ACQUITY UPLC H-Class Series with an SQD2 single quadrupole mass detector (Waters, Tåstrup, Denmark) equipped with an ACQUITY Premier Peptide CSH C18 Column (1.7 µm, 2.1 × 100 mm, 130Å, Waters).
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PMC11300639
RNF26 is a member of the RING finger protein family and is located in the human chromosome 11q23 region.
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PMC9429973
Summary/Conclusion: This approach allows the acquisition of deeper insights into the molecular mechanisms underlying the development and maintenance of leukemia with CEBPA mutations.
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PMC11700165
Structure and function correlation of the fusion kinases.
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PMC10440586
The immune checkpoint blockade (ICB) resistance level demonstrated in Supplementary Figure 5 was predicted using the TIDE method on the webserver (http://tide.dfci.harvard.edu/).
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PMC11794568
HR (95% CI) Univariate analysisP value Univariate analysisHR (95% CI) Multivariate analysisP value Multivariate analysis Pathologic T stage 362T1&T2119ReferenceReferenceT3&T42432.099 (1.511–2.914)< 0.0010.894 (0.509–1.570)0.697 Pathologic N stage 403N0225ReferenceReferenceN1&N2&N31781.760 (1.310–2.365)< 0.0012.259 (1.527–3.343)< 0.001 Pathologic M stage 431M0407ReferenceReferenceM1241.902 (1.032–3.506)0.0392.046 (0.818–5.118)0.126 Melanoma ulceration 314No147ReferenceReferenceYes1672.099 (1.506–2.927)< 0.0011.404 (0.934–2.111)0.103 Melanoma Clark level 316I&II&III96ReferenceReferenceIV&V2202.184 (1.520–3.137)< 0.0011.390 (0.858–2.249)0.181 Tumor tissue site 357Extremities191ReferenceTrunk1660.943 (0.695–1.280)0.707 Gender 457Female173ReferenceMale2841.180 (0.885–1.574)0.261 Age 457<= 60247ReferenceReference> 602101.663 (1.256–2.201)< 0.0011.184 (0.798–1.757)0.402 Weight 249<= 7072Reference> 701770.649 (0.389–1.083)0.098 Height 244< 170112Reference>= 1701320.855 (0.556–1.316)0.477 BMI 241<= 2579Reference> 251620.827 (0.513–1.333)0.436 Breslow depth 356<= 3181ReferenceReference> 31752.665 (1.948–3.644)< 0.0011.890 (1.126–3.172)0.016 CRIP1 4570.492 (0.366–0.659)< 0.0010.518 (0.347–0.774)0.001 Univariate and multivariate Cox proportional hazards analysis for CRIP1 expression.
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PMC7090062
Equal amounts of protein (40 µg) were separated by 10% sodium dodecyl sulfate-polyacrylamide gel electrophoresis and then transferred to polyvinylidene difluoride membranes (Millipore, Bedford, MA, USA) by electroblotting.
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PMC7039683
Interestingly, in a single mouse embryo with 8 copies of the SNP2 transgene construct, reporter expression was clearly detected in external periderm.
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PMC9429973
Occurrence of G3 liver toxicity in patients receiving combination therapy deserves attention and further studies.
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PMC11389534
Both UFSP2 and ODR4 contain an Mpr1p and PAD1p N‐terminal (MPN) domain, allowing them to form a dimeric complex.
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PMC9429973
A positive T-cell response was defined as IFN-ɣ release > 200 mIU/mL. Data on diagnoses were obtained through medical records, and data on vaccination status were obtained from the Danish Vaccination Register.
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PMC10419319
The results demonstrated that isoalantolactone effectively inhibited the growth of cisplatin-resistant OC cells, particularly A2780 and SNU-8 cells.
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PMC9780037
In the cytoplasm of cancer cells, the reductive chemical environment induces the cleavage of the disulfide bond and consequent release of cyt c. (B) Nanoparticle-based delivery systems are usually coated with ligands (represented in red) that recognize cancer cells through surface makers (represented in brown).
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PMC10507284
As present in Figures 7G and H, the wound healing assay indicates that the mean percentage wound healing of SW982 at 24 and 48 h in the TROAP‐NC group are 62.51 and 86.29%, while those in the TROAP‐siRNA group are 27.90 and 48.70%, respectively.
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PMC8711270
With the increasing number of cell and gene therapies being developed (Rittié et al., 2019; Lapteva et al., 2020), we will see a corresponding growth in the use of HEK293 in viral vector production.
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PMC11787355
Since the complete open reading frame (ORF) of PTPRZ1 is large (~7kbp), we generated a well-characterized HLA-A*02 glioblastoma cell line (U87) stably expressing a tandem minigene (TMG) encoding several antigens derived from the GAPVAC-101 and IMA950 trials, including the PTPRZ1 antigens of interest (Supplementary Fig. 4a, b, Supplementary Table 1).
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PMC11381192
We examined the expression levels of genes in the CSI signature under different scenarios.
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PMC11352311
Interestingly, we observed differential IC50 values for esculin in the two RCC cell lines.
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PMC11687663
The measurement of absorbance was conducted at wavelengths of 570 nm and 630 nm .
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PMC11371627
Our patient with the novel XK deletion (F) showed no restriction in expression of the KEL gene on RNA level.
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PMC11768281
CD8+ T cells are essential for liver-stage immunity (pre-erythrocytic phase), while CD4+ T cells dominate during the erythrocytic stage by supporting cytokine production and antibody responses .
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PMC11483468
The TAT sequence was inserted into pGEX-6p-1 (Addgene, Watertown, MA, USA) to generate the recombinant plasmid pGEX-6p-1-TAT, and then the cDNA encoding LPTS290-328 was cloned and inserted into the pGEX-6p-1-TAT vector to generate the plasmid GST-TAT-LPTS290-328 by the primers (F: 5'-CGGGATCCACCCTGAAGCCCAAAAAG-3'; R: 5'-CCCTCGAGTTTGGAATCTTTCTTCTTCTTC-3').
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PMC11591030
NO.
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PMC9388315
Soumya et al. showed that in cervical cancer cells aqueous extract of Cinnamon increases intracellular calcium signaling and alters the permeability of mitochondrial potential consequently inducing apoptosis .
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PMC11746948
The ESI source conditions were set as following: sheath gas flow rate as 30 Arb, Aux gas flow rate as 10 Arb, capillary temperature 320 °C (positive), 300 °C (negative), full MS resolution as 70,000, MS/MS resolution as 17,500, collision energy as 15/30/45 in NCE mode, spray Voltage as 5 kV (positive) or –4.5 kV (negative), respectively.
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PMC11626627
Despite advances in medical technology enabling early diagnosis of smaller kidney tumors, approximately 30 % of ccRCC patients are still diagnosed at an advanced stage.
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PMC6182045
Indeed, site-specific glycan analysis of gp140 proteins identified up to 70 unique glycoforms occupying a single N-linked glycosylation site (37).
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PMC11635087
For example, kinetic analyses may be conducted and selected substances may be tracked by incorporating isotope-labeled chloroplasts.
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PMC11765879
There was a significant upregulation in the expression of the pro-apoptotic marker Bax, with no significant changes in the expression pattern of the anti-apoptotic marker Bcl-2 in both cell lines.
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PMC10938336
The Cytoscape platform to integrate compound–target information significantly can enhance the understanding of interaction networks and potential synergistic effects.
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PMC11670407
Images of the scratches were taken using an inverted microscope (Evos flauto, Life technologies, USA) at × 10 magnification at 0 and 24 h of incubation.
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PMC11352746
Suspend the cells initially with BrainBits NbActiv media (Cat# NbActiv1 500) and count the cells using a hemocytometer and Gibco Neurobasal plus media (Cat. #
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PMC11453018
Clustering of patients was executed using NMF (version 0.27).
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PMC11420784
The stained cells or bladders were imaged with a Zeiss LSM800 confocal microscope.
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PMC11770746
Percentage body weight changes over time as an indicator for general toxicity. (
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PMC11643361
These coordination compounds have a widespread use, starting from their applications as catalysts for polymerization, oxidation, and nitrene transfer reactions to bioorganic and medicinal chemistry for modeling enzyme, antimicrobial, antioxidant, and anticancer activity .
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PMC11638288
Inhibition of NKp46 in NK cells reduces their degranulation, thereby implicating NKp46 in the recognition of RA-FLS by NK cells.
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PMC10033453
B–E) Tumor infiltrating lymphocyte (TIL) subsets were compared between VMG and PBS control mice by flow cytometry.
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PMC11747467
The tumor volume was calculated using the formula: volume = 0.52 * L * W. After approximately 3 to 4 weeks, all the mice were euthanized, the tumors were isolated, and the subsequent analyses were conducted.
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PMC7189327
We also observed that CDC20 exhibited a good performance for BCC diagnosis based on a ROC analysis.
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PMC8922418
The above studies lay a foundation for the design of CRISPR/SaCas9 in human HIV-1/AIDS clinical trials.
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PMC9429973
The severity degree of COVID-19 at the onset was defined by the need of Continuous Positive Airway Pressure devices (C-PAP) or tracheal intubation as compared to no-oxygen need, or use of nasal flow, reservoir mask, or Venturi Mask.
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PMC11549062
In the context of live cell imaging, cells labeled with fluorescent markers were cultured on glass‐bottomed MatTek dishes until reaching 70% confluency.
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PMC7351993
By tracking Raman shifts accompanied by cellular incorporation of an added stable isotope probe enables evaluation and comparison of intracellular metabolic activity at a given time.
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PMC8992508
The NBD is located within cytoplasm; ATP binding and hydrolysis supply the energy for the transport of substrates across the membrane.
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PMC5854676
Table 1Values of different constants used in the model given in Eq. (3) and indicators of curve fitness.
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PMC11437637
P < 0.05 (in bold) was considered to be statistically significant Abbreviations: NK Natural Killer cell, NKT Natural Killer T cell, PBL Peripheral Blood Lymphocyte, EC endometrial carcinoma Gynecological tumor studies, including those by our group, have reported lymphocytes changes in patients with ovarian and cervical cancers.
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PMC9341513
The height of the orange shaded region represents the relative frequency at which that position interacts with the viewpoint.
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PMC11703896
After incubation, biomass of S. hygroscopicus was ruptured using ultrasonication and removed by centrifugation at 8000 rpm for 6 min followed by filtration using Whatman filter paper and the supernatant was collected.
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PMC11394227
Finally, the total antioxidant capacity per milligram or gram of protein was calculated in mmol/mg or mmol/g.
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PMC9429973
A subset of hypermethylated enhancers in monosomy 7 was in accordance with repression of their respective target genes, almost totally located on chromosome 7 (ARPC1A, CCZ1, IKZF1, PMS2, RBAK, RBM33, RHEB, RNF216P1, ZNF12 and ZNF853).
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PMC11612794
CENP-T is shown as a cartoon.(B) Localization of GFP-Dsn1.
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PMC10969097
Currently, medical priorities are centred on finding new therapeutic strategies with fewer side effects.
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PMC11216402
DNA CN changes in Mes-like and Epi-like GC cell lines. (
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PMC11661040
Results from three experiments are summarized in a histogram format.
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PMC11216402
All raw and processed sequencing data generated in this study have been submitted to the NCBI Gene Expression Omnibus (GEO; https://www.ncbi.nlm.nih.gov/geo/) under accession numbers GSE264550 and GSE266159.
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PMC11719944
Memory T cells can hold onto their protective function against familiar threats for many years without needing to be reminded of those threats .
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PMC5535901
Phosphorylation was very rapid and was captured at 10 min for p-IκB-α and 30 min for p-NF-κB-p65, following PMA/ionomycin incubation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phosphorylation", "was", "very", "rapid", "and", "was", "captured", "at", "10", "min", "for", "p-IκB-α", "and", "30", "min", "for", "p-NF-κB-p65", ",", "following", "PMA/ionomycin", "incubation", "." ] } ]
PMC8357004
This article was supported by the adjutancy of research of Jahrom medical University-Iran.
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PMC11759543
Primary antibodies for β-actin (A5441; 1:10000) were purchased from Sigma-Aldrich (St. Louis, USA).
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PMC10203589
Effects of FGF18 on tissue and cell aspects of CRC.
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PMC11012012
Shi et al. (2018) used immunohistochemistry to analyze 20 PBL cases, including 11 PBL not otherwise specified (PBL NOS), 5 HIV+ PBL, 2 ALK+ large B cell lymphomas (LBCL), 1 primary effusion lymphoma, and 1 PBL with angioimmunoblastic T cell lymphoma (AITL).
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PMC11727907
Differences were considered statistically significant when p < 0.05.
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PMC11064533
Leading logFC values were used to generate an MDS plot using ggplot2 (23).
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PMC11698348
E74-like factor 5 (Elf5) is a member of the E26 transformation specific (ETS) family of transcription factors, which is expressed predominantly in epithelial cells and it has a wide spectrum of biological and physiological roles in epithelial development .
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PMC9429973
There is limited literature on the patient and procedure related factors associated with the pain.
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PMC11381192
ANXA2 promotes proliferation, inhibits apoptosis, and enhances angiogenesis in MM cells.
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PMC11755467
Using this approach, some structures of class of fluoroquinolone antibiotics emerged due to their reported protection of HIV-1-induced cytopathic effects and inhibition of virus replication in MT-4 T-cells .
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PMC5925824
Panel e: Gene expression analysis of tumor sample was performed using QuantiGene Plex assay.
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PMC9429973
WU-NK-101 is an ‘off-the-shelf’ Memory NK cell therapy product derived from healthy donor cells, generated using Wugen’s proprietary MONETA™ process and scaled for commercial utility.
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PMC5925824
Canine PD-L1-Fc and its mutants were expressed transiently in Expi293F cells following transfection using ExpiFetamine 293.
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PMC11190062
TLR4 and TLR9 activation protects against PI-induced cytotoxicity. (
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PMC11697065
Venn diagrams were plotted using VennDiagram package in R (4.3.1).
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PMC11594074
For the docking simulations, the X-ray crystallographic structure of human DNMT1 was extracted from the Protein Data Bank (PDB) (https://www.rcsb.org/, accessed on 4 July 2024, PDB ID 4WXX).
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PMC11406030
Viability of cells was determined by the TACS MTT proliferation assay kit. (
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PMC11463018
In this research, the rationale for the dual-inhibitor design originated from our sweeping investigations on reported X-ray crystal structure of Filgotinib bound to JAK2 (Figure 3(A)).
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PMC9884169
The dilution ratios of the above secondary antibodies were 1 : 5000.
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PMC11732635
Our case report shows that CAR T-cell therapy is relatively safe for treating CAEBV in children, and the degree of cytokine release syndrome (CRS) is relatively milder than that of malignant tumors.
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PMC9429973
Multivariate analysis of 71 IgD patients who received ‘novel therapies’ identified that R-ISS stage Ⅲ, complex karyotypes and deletion of 13q were independent adverse factors for OS, whereas complex karyotypes and thrombocytopenia were independent adverse factors for PFS.
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PMC11467964
Moreover, ROC of the nomogram was 0.739, 0.832, and 0.853 in 1‐, 3‐ and 5‐year, respectively.
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PMC10808409
Whereas a positive coefficient of X23 indicated a synergistic effect between those 2 variables.
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PMC10380508
The re-expression of PAX2 has been suggested to be required for renal tubular regeneration, proliferation, and repair .
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PMC2614415
Treatment of 1A9 and PTX10 cells with VE-465 resulted in a dose-dependent increase in Caspase 3 and Caspase 7 activity that was inhibited by pretreatment with the general caspase inhibitor Z-VAD (Fig. 3C and 3D).
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PMC11803918
The successful fusion between γδ-T exosomes and liposomes was determined by small particle detection and the Förster resonance energy transfer (FRET) effect.
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PMC6803987
The mixture was subjected to cell counting in the same manner as described above.
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PMC9429973
Given that tamibarotene plus aza has been generally well tolerated, with no increase in myelosuppression compared to single agent aza (de Botton 2020), it is anticipated that tamibarotene can be administered safely in combination with ven/aza.
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PMC11320084
a–d) Lithium chloride (LiCl) partially restored the EMT‐related and Wnt/β‐catenin pathway‐related protein expression in LC cells with knockdown of TNNT1.
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PMC11697703
We used unpaired Student’s t-tests, Fisher’s exact test, or ANOVA followed by Tukey post hoc test for statistical comparison.
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PMC11509224
A total of 17 diterpenes were obtained from Acanthella sponges.
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PMC11486946
M indicates molecular weight marker.
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PMC11640419
It is noteworthy that the role of JNK is still a topic of considerable debate among researchers.
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PMC11225860
After blocking slides were washed three times with TBS-T and then stained with DAPI and rabbit CENP-B (Cell signaling Technology).
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