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PMC9545714
Olfactory receptors are G‐protein coupled receptors.
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PMC10631132
Our group previously developed engineered murine OCs (iRANK cells) by transfecting OC precursors with a viral construct containing an intracellular receptor activator of nuclear κB (RANK) signaling domain linked to a fusion protein (FKBP12) that provides a binding site for the chemical inducer of dimerization (CID), allowing for a drug-controlled cell differentiation independent of receptor activator of nuclear factor κB ligand (RANKL) and osteoprotegerin (OPG) .
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PMC11615743
The stability of L‐DNA probes in biological samples could enable more reliable detection of biomarkers or pathogens.
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PMC10024132
The resulting construct was transformed into E. coli TOP10 (Invitrogen) for amplification and then purified using a Maxiprep plasmid purification kit (Qiagen).
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PMC8469018
The thiols level did not differ from the level observed in the control cells.
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PMC10734950
Following exposure, the data was obtained via densitometry and normalized according to the protocol data analysis.
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PMC11738017
Taken together, we showed in this study that anti-BCMA TCE cytotoxicity is dependent on the ratio of T-cell engagement per mBCMA molecules, which is factorized by the combinatorial effect of sBCMA, mBCMA, E:T ratio, and TCE dosing (Figure 7A).
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PMC11499381
Colony PCR using T7 and BGH primers followed by gel electrophoresis was performed to investigate whether colonies contained the insert of interest.
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PMC6650823
A new opportunity towards this end was now opened upon the disclosure of fosmidomycin-inspired prodrugs as antimalarial and antitubercular leads, by Courtens et al. .
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PMC11487720
Increased NO production was shown (stained with green fluorescent DAF).
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PMC11783017
The results show that the TME-responsive nanocomposite hydrogel possesses enhanced anti-tumor efficacy in MYC-amplified OS, which supports further development of rational combination therapy for MYC-amplified tumor treatment.
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PMC11267830
This elevated expression of RBM39 was further validated through Western blotting in various T-ALL cell lines, including Jurkat, J.gamma1, 6T-CEM, CCRF-CEM, MOLT-4, and HUT-78 (Fig. 4b).
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PMC11422497
Total RNAs from each sample were extracted using the RNeasy Mini Kit (Qiagen, Hilden, Germany).
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PMC11424574
The expression of Ki-67 and MTA2 in the lung tissue sections was determined using immunohistochemical analysis.
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PMC6034753
MSB-1 is one of the first such cell lines established , and has since been studied extensively to understand the molecular basis of MDV latency .
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PMC10810426
Primary antibodies used were mouse anti-NUP358 (sc-74518, Santa Cruz), mouse anti-NUP62 (610498, BD Biosciences), rabbit anti-NUP88 (AB231187, Abcam), rabbit anti-NUP153 (E316Z, Cell signaling), and rabbit anti-NUP214 (AB70497, Abcam).
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PMC9910796
No pEP84R-Flag band was detected when anti-V5 antibody was omitted or replaced by an irrelevant antibody, nor when anti-V5 antibody was incubated with cell lysates expressing only pEP84R-Flag.
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PMC6163708
Colorectal cell lines LoVo, SW480, HCT116 were from ATCC.
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PMC11721096
For the final wash, 30% methanol was used as the desorption solvent to extract the potential ligands designated as mS5.
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PMC10329074
P < 0.001.
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PMC11422497
However, further investigation into the precise mechanisms by which circ_SMA4 mediates oncogenesis in GISTs is imperative to fully realize its clinical implications and therapeutic potential.
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PMC11680982
The cell cycle assay was performed in HR/HER2-low breast cancer cells administered the triple combination of 125 nM neratinib, CDK4/6 inhibitor (100 nM, palbociclib), and endocrine therapy (100 nM, ET, fulvestrant).
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PMC11612794
DNA was stained with DAPI.
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PMC9918897
The diagnosis was a high-grade, immature, solid carcinoma.
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PMC11441402
Absorbance was read at 570 nm on the Multiskan SkyHigh Microplate spectrophotometer.
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PMC9688728
Thus, no significant changes were found in the state of the culture on days 0 and 20.
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PMC11665555
Chemotherapy is often combined with surgery for muscle invasive and nonmuscle invasive bladder cancer (BCa).
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PMC11515150
NK cells and T cells were incubated with PE-Labeled Human CD5 protein, His Tag (ACROBiosystems, China) for CD5-CAR expression.
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PMC7171147
FAO inhibitors, such as etomoxir, perhexiline, and ranolazine, have been approved by FDA and/or EMA for heart diseases and are currently being evaluated in various stages of clinical trials as anticancer agents.
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PMC11711871
An increase in the active form of linoleic hydroxyoctadecadienoic acid 9-HODE and in the inactive forms, namely, 9(10)-DiHOME, 12(13)-DiHOME, 9-KODE, and 13-KODE, was observed in the 10-week-old GR rats (Fig. 3A–D).
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PMC11473843
Hierarchical clustering (Pearson Correlation, average linkage) of genes with standard deviation at top 5% showing a clear separation between A549 cells treated with VS-4718 (2.5 µM) for 12 h (acute) or rendered VS-4718 tolerant as described in (A); n = 3. (
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PMC9429973
Response is evaluated by investigator and by independent oncologic response adjudication (IORA; primary assessment) using Lugano Classification with LYRIC modification.
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PMC11129910
To test this, we chose the following oncogenes: H-RASV12G, H-RAS61L, and IGF1-R; around 50% of breast tumors express activated IGF1-R .
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PMC6835428
Other reviews have covered additional delivery systems .
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PMC11412721
Quantifications are relative to actin.
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PMC11721277
The temperature of the column thermostat is 40 °C.
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PMC11012012
Similar results were also reported by de Salort et al. (2011) who observed that SLAMF3/CD229 was positive in Daudi (80–100% positive cells) and partially positive in Namalwa (40–60%), Raji (60–80%), and Ramos (20–40%) cells .
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PMC9429973
Safety endpoints were incidence of treatment-emergent adverse events (TEAEs) and AEs of special interest.
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PMC9429973
Methods: Multicenter retrospective study that included patients ≥ 18 years of age with NDMM who received upfront ASCT as consolidation between 2015 and 2020 at six transplant centers in Mexico.
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PMC9429973
Four patients were treated with tyrosine kinase inhibitor (TKI) alone with the achievement of complete remission (CR) in 3/4 of the cases while one patient was treated with the combination TKI and chemotherapy with good evolution.
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PMC11792090
Additionally, flow cytometry analysis confirmed that knockout efficiency was maintained during the scale-up process ( Figure 8E ).
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PMC11676674
Thus, in the present study, we aimed to evaluate the cytotoxic, genotoxic, and antigenotoxic effects of a methanolic extract of C. monspeliensis leaves in vitro using the Chinese Hamster Ovarian K1 (CHO-K1) rodent mammalian cell line in the absence or in the presence of a well-known genotoxic agent, namely mitomycin C (MMC).
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PMC11224020
Such a regulatory mechanism could limit the number of DCs that acquire CCR7 expression and migrate to lymph nodes as a result of shape sensing during environment patrolling, thereby increasing their time of tissue residency.
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PMC9429973
Summary/Conclusion: BM Tfr2 deletion and RAP-536 treatment had additive effect in correcting IE and anemia in β-thalassemic mice.
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PMC9429973
RG6234 is a T-cell engaging bispecific antibody targeting GPRC5D with a novel 2:1 format.
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PMC11684297
Nanoparticles have an enormously high surface area to volume ratio that imparts an effective role at an ultra-low concentration compared to their bulk counterpart .
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PMC10055960
Yield: 0.051 g, 76%.
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PMC9429973
Summary/Conclusion: High-risk characteristics including DHL/THL and DEL are significantly associated with progressive disease during frontline treatment, suggesting that MYC-signaling may mediate chemoresistance.
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PMC11228511
The numbers of cells scored in three independent experiments (circles) are shown in parentheses.
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PMC11321678
Enrichment of ATAC‐seq accessibility at TSSs was used to quantify data quality.
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PMC11507371
B, left) Also, A431 cells exhibited significantly reduced levels of NF-κB after CAP treatment. (
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PMC11653533
On the other hand, plant-based medications are increasingly acknowledged for their powerful therapeutic advantages and reduced negative responses.
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PMC9429973
Aims: Evaluate the response rates and prognostic factors of GI-GVHD patients Methods: GI-GVHD was diagnosed clinically and/or histologically and graded by MAGIC criteria.
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PMC9856122
BBR was also found to be effective against severe post-COVID conditions such as pulmonary fibrosis and reduced inflammation during COVID-19 pneumonia .
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PMC11731614
Jeffrey N. Savas: Writing – review & editing, Supervision, Resources, Methodology.
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PMC10891340
To detect the ability of CCCP on mitophagy in DEF, we tested a variety of mitochondrial proteins, selecting mitochondrial proteins (TOM20, MFN2) as well as autophagy proteins (LC3-Ⅰ, LC3-Ⅱ).
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PMC6799808
To elucidate how GLPT inhibits lung cancer cell proliferation, cell cycle analysis was conducted.
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PMC11766309
Furthermore, mutations in the YKT6 gene were the most common type of genetic change in uterine corpus endometrial carcinoma (>1%) and skin cutaneous melanoma (>1%), whereas substantial deletions were observed in esophageal adenocarcinoma.
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PMC11609529
There were no significant differences between MAML2-KO and control cells in terms of viable cell numbers, apoptotic cells, or cell cycle profiles (Figures 5B–5D).
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PMC11518702
To assess effects of HGAL on DLBCL tumorigenesis, human DLBCL and Burkitt lymphoma cell lines have been assessed in xenograft studies (NOD/SCID mice) (10).
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PMC11334037
The opposite result was noted after IGF2 knockdown (Figure 3B, P < 0.01, P < 0.001).
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PMC8751435
As a dietary therapy, CME exerts mild anticancer effect with validated and potential targets, refinement is needed through enriching bioactive component according to our findings.
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PMC11695623
The results show that DCUN1D5 contributes significantly to the prediction of OS in the nomogram model (Fig. 4A).
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PMC11021472
The region where these ends are linked is known as the back-splice junction (BSJ) region.
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PMC11394227
The results of the KEGG enrichment analysis indicated that the KEGG pathway (map04141) exhibited a relatively complete array of ER activities, encompassing the correct protein processing, endoplasmic reticulum-associated degradation (ERAD), and the UPR signaling pathway (Supplementary Figure S2).
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PMC11609529
We constructed a YM fusion consisting of YAP1 (1–328 aa) and MAML2 (172–1153 aa) tagged with GFP at its N terminus and transfected this GFP-tagged YM fusion into COS7 cells.
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PMC9352806
In accordance with Lin's findings (Lin et al., 2020), the ability of momordica saponins extracts improving lifespan was attributed to the stress resistance effect.
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PMC9429973
L. Zhang, J. Mao, Y. Lian, Q. Liang, H. Pan, Z. Gao, W. Li, J. Zhao, L. Fang, Y. Chu, W. Yuan, J. Shi Regenerative Medicine Clinic; Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China Background: Aplastic anemia (AA) is a bone marrow failure syndrome attacked by autologous T cells.
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PMC10976516
Nevertheless, when lung cancer presents itself in its most deadly metastasizing form, OV therapy can only secure some efficacy after systemic application.
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PMC9844987
Variability of promoters grouped by their number of predicted non-overlapping ETS binding sites split based on promoter expression level quartiles.
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PMC11653533
In a study, six phytochemicals including cinnamic acid, lactose, quercetin, caffeic acid and stigmasterol obtained from F. benjamina leaves, barks, and fruits were screened for antimicrobial activity against B. cereus and P. aeruginosa, and cytotoxic activity against T-lymphoblastic leukemia (CEM-SS) cell line.
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PMC11116779
The day before PS-NP treatment, cells were seeded at a density of 500,000/well and grown under standard culture conditions in 6-well plates.
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PMC11528603
The extracts were prepared from fresh fruits and the phytochemical contents were evaluated by biochemical assays and HPLC method.
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PMC8735881
As noted, GPI-10E8-modified cells completely blocked the infection of divergent HIV-1 subtypes, except for the pseudovirus CNE55, which infected the cells with an average infection rate of 1%.
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PMC9118379
Moreover, OMS against SuperPep_V (light green bar), i.e., the combined search, had a decrease of 13.2–28.4% variant PSMs compared with OMS against RefP_V (light blue bar).
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PMC11681005
Informed consent was obtained from all subjects.
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PMC7762347
p < 0.05, ** p < 0.01, *** p < 0.001 and **** p < 0.0001).
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PMC2777936
With the discovery of more Wnt receptors, non-Wnt ligands and Wnt-independent Frizzled activation, a new view of the Wnt pathway is being proposed: that it is the receptor and downstream effector context, in addition to ligand identity, which determines ultimate signalling output .
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PMC11188874
E, Chemical structure of clinically relevant HDAC6 inhibitors.
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PMC11400680
The use of FCN for cell segmentation from unstained microscopic images can be seen in References (12-16).
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PMC9429973
L. Sanchez-Paz, M. J. Solaeta Gómez, N. Varona Torralvo, P. Molina Mejías, E. Valencia Ospina, M. A. Rodriguez Calderita, V. Díez Viñas, V. Ramos de Ascanio, C. Muñoz Novas, J. Churruca, M. S. Infante, E. Landete, K. Marín, M. Á. Foncillas, J.-Á. Hernández-Rivas, I. González-Gascón-y-Marín Hematology Department; Day-Hospital Unit, Infanta Leonor University Hospital, Madrid, Spain Background: In the last few years the widespread use of peripherally inserted central catheter (PICCS) has provided a benefit for patients with hematological disorders.
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PMC7724160
In this article, we provide four data sets for an industrial Chinese Hamster Ovary (CHO) cell line producing antibodies during a 14-day bioreactor run.
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PMC11767817
Therefore, for further studies, we selected 5637 cells and the most potent compound, 2a-B, along with compound 2a, its counterpart without the BF2 group.
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PMC11464982
The frequency of cells with micronuclei was not statistically significantly different to the negative controls at all concentrations tested.
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PMC11736898
Keratinocytes were released from epidermis using trypsin digestion and were cultured initially in collagen-coated flasks in keratinocyte growth medium consisting of MCDB-153 with 0.06 mM CaCl2 supplemented with 1 ng/ml epidermal growth factor (PeproTech, Rocky Hill, NJ), 0.5 μg/ml hydrocortisone (Sigma Aldrich, St. Louis, MO), 5 μg/ml human insulin (Sigma Aldrich), 0.2% bovine pituitary extract (Hammond Cell Tech, Windsor, CA) and 1X Penicillin–Streptomycin–Fungizone (Thermo Fisher Scientific, Waltham, MA).
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PMC11543935
Both devices were set to deliver 8 rectangular pulses with 1000 V/cm, 160 µs pulse length and 25 cycles.
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PMC11291697
After reads alignment, variant calling, annotation, and removal of possible artefacts was done as previously reported .
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PMC11478724
Specifically, after being exposed to PMX, the cells in A549 showed a significant increase in the production of ROS.
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PMC11011837
This result could also indicate a variation in the activity of enzymes involved in this pathway, such as ornithine transcarbamylase and argininosuccinate synthase 1.
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PMC11789597
This drug has been approved by the FDA for treating acute lymphoblastic leukemia, lymphoma, and other immune‐related diseases.
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PMC10713411
Then, the proteins were transferred onto a PVDF membrane where they were totally blocked with a blocking buffer.
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PMC11683240
Importantly, purified α1AT is already in use clinically as an intravenous augmentation therapy for those with genetic α1AT deficiency and could be repurposed to clinical management of pertussis.
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PMC9429973
The negative predictive value of PETINT results was 96%.
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PMC10854447
After the reaction was completed (monitored with TLC), the excess solvent evaporated under reduced pressure.
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PMC11222184
The anti-GAPDH (1:5000) primary antibody was used for normalization.
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PMC7841067
Thus, AKAP4 may act as a potential therapeutic target for human thyroid cancer.
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PMC11721064
B GSEA enrichment analysis of corneal versus skin cells.
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PMC8978939
This result suggests that the novel pVHL variants might have a different behavior compared to WT pVHL under more physiologically challenging conditions.
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PMC9429973
Aims: To report updated results from an ongoing multicenter, phase 2, open-label study of the phosphoinositide 3-kinase-δ inhibitor parsaclisib in patients (pts) with AIHA (NCT03538041).
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PMC11612315
This finding was further validated by the absence of blood glucose changes in wild-type mice following the administration of exendin 20–29 at effective doses, in contrast with the hypoglycemic effect observed with exendin-4.
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