Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC2196094
We can from these data conclude that the transcription factors and cell surface markers tested are expressed at much lower levels compared to the most abundant granule components.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "can", "from", "these", "data", "conclude", "that", "the", "transcription", "factors", "and", "cell", "surface", "markers", "tested", "are", "expressed", "at", "much", "lower", "levels", "compared", "to", "the", "most", "abundant", "granule", "components", "." ] } ]
PMC8728081
The NIH3T3 (mouse fibroblast) cell line was obtained from National Centre for Cell Science, Pune, India.
[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "NIH3T3", "(", "mouse", "fibroblast", ")", "cell", "line", "was", "obtained", "from", "National", "Centre", "for", "Cell", "Science", ",", "Pune", ",", "India", "." ] } ]
PMC9429973
Detection of CAR-T was superior with the FFM platform (median difference per PBS - 2, IQR 0-6, p<0.001).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Detection", "of", "CAR-T", "was", "superior", "with", "the", "FFM", "platform", "(", "median", "difference", "per", "PBS", "-", "2", ",", "IQR", "0", "-", "6", ",", "p<0.001", ")", "." ] } ]
PMC9429973
Results: Our workflow excelled at predicting patient responses to first line treatment, with an overall predictive power of 85% accuracy and a diagnostic odds ratio of 47.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Our", "workflow", "excelled", "at", "predicting", "patient", "responses", "to", "first", "line", "treatment", ",", "with", "an", "overall", "predictive", "power", "of", "85", "%", "accuracy", "and", "a", "diagnostic", "odds", "ratio", "of", "47", "." ] } ]
PMC11322866
In this work, GSK126 (an EZH2 inhibitor) induced cellular senescence by promoting ERK1/2 phosphorylation, while RRM2 overexpression also inhibited EZH2 and promoted ERK1/2 phosphorylation and cellular senescence.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "work", ",", "GSK126", "(", "an", "EZH2", "inhibitor", ")", "induced", "cellular", "senescence", "by", "promoting", "ERK1/2", "phosphorylation", ",", "while", "RRM2", "overexpression", "also", "inhibited", "EZH2", "and", "promoted", "ERK1/2", "phosphorylation", "and", "cellular", "senescence", "." ] } ]
PMC11686380
The role of GAP43 in dendritic development in the developing central nervous system remains unclear.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "role", "of", "GAP43", "in", "dendritic", "development", "in", "the", "developing", "central", "nervous", "system", "remains", "unclear", "." ] } ]
PMC11786156
Adhesion assay revealed that HBL-2 showed more frequent adhesion in the 10 μg/mL and 100 μg/mL LFA1/(CD11a/CD18)-coated microplates than the negative controls at 0 μg/mL. In the WST-1 assay, 10 μg/mL and 100 μg/mL LFA1-treated HBL-2 showed significantly more viability than the negative controls at 48 h, suggesting cell proliferation.
[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adhesion", "assay", "revealed", "that", "HBL-2", "showed", "more", "frequent", "adhesion", "in", "the", "10", "μg/mL", "and", "100", "μg/mL", "LFA1/(CD11a/CD18)-coated", "microplates", "than", "the", "negative", "controls", "at", "0", "μg/mL.", "In", "the", "WST-1", "assay", ",", "10", "μg/mL", "and", "100", "μg/mL", "LFA1-treated", "HBL-2", "showed", "significantly", "more", "viability", "than", "the", "negative", "controls", "at", "48", "h", ",", "suggesting", "cell", "proliferation", "." ] } ]
PMC11637284
The C-terminal p166 segment D1466-L1499 is shown in green. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "C-terminal", "p166", "segment", "D1466-L1499", "is", "shown", "in", "green", ".", "(" ] } ]
PMC10998613
PIE-FCCS data were analyzed using MATLAB (MathWorks) and Excel spreadsheet.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PIE-FCCS", "data", "were", "analyzed", "using", "MATLAB", "(", "MathWorks", ")", "and", "Excel", "spreadsheet", "." ] } ]
PMC11322866
OIS is a persistent antiproliferative response that acts as a barrier against malignant transformation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OIS", "is", "a", "persistent", "antiproliferative", "response", "that", "acts", "as", "a", "barrier", "against", "malignant", "transformation", "." ] } ]
PMC10440586
Kaplan-Meier curves of the Schalper dataset; patient groups were divided by pre-treatment CD99 expression level. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan-Meier", "curves", "of", "the", "Schalper", "dataset", ";", "patient", "groups", "were", "divided", "by", "pre-treatment", "CD99", "expression", "level", ".", "(" ] } ]
PMC10387886
Western blot analysis was performed as previously described .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", "was", "performed", "as", "previously", "described", "." ] } ]
PMC11467964
F–K) Relationships between risk score and chemotherapeutic sensitivity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "–", "K", ")", "Relationships", "between", "risk", "score", "and", "chemotherapeutic", "sensitivity", "." ] } ]
PMC11612508
The resulting Graphene Oxide (GO) precipitate was first washed multiple times with a 5% HCl solution to eliminate sulfate ions (confirmed by the BaCl2 test) and then repeatedly rinsed with UP water to remove chloride ions (verified by the AgNO3 test).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resulting", "Graphene", "Oxide", "(", "GO", ")", "precipitate", "was", "first", "washed", "multiple", "times", "with", "a", "5", "%", "HCl", "solution", "to", "eliminate", "sulfate", "ions", "(", "confirmed", "by", "the", "BaCl2", "test", ")", "and", "then", "repeatedly", "rinsed", "with", "UP", "water", "to", "remove", "chloride", "ions", "(", "verified", "by", "the", "AgNO3", "test", ")", "." ] } ]
PMC11740399
These vesicles were incubated with 3025@L at 37°C for 15 minutes and then ultrasonicated on ice for 3 minutes to completely fuse the liposome (Lipo) and tumor membrane (Mem), forming 3025@ML.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "vesicles", "were", "incubated", "with", "3025@L", "at", "37", "°", "C", "for", "15", "minutes", "and", "then", "ultrasonicated", "on", "ice", "for", "3", "minutes", "to", "completely", "fuse", "the", "liposome", "(", "Lipo", ")", "and", "tumor", "membrane", "(", "Mem", ")", ",", "forming", "3025@ML", "." ] } ]
PMC11486946
The stability and internalization of EGFR were further examined in the EGFR-expressing cell lines by immunofluorescence microscopy, in which the photophysical effect of verteporfin need not be considered.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "stability", "and", "internalization", "of", "EGFR", "were", "further", "examined", "in", "the", "EGFR-expressing", "cell", "lines", "by", "immunofluorescence", "microscopy", ",", "in", "which", "the", "photophysical", "effect", "of", "verteporfin", "need", "not", "be", "considered", "." ] } ]
PMC6222726
Pentacyclic triterpenoids are largely present in the resin of several species, and the study of triterpenoidic composition of resins is important to define the botanical origin of archaeological samples of copal .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pentacyclic", "triterpenoids", "are", "largely", "present", "in", "the", "resin", "of", "several", "species", ",", "and", "the", "study", "of", "triterpenoidic", "composition", "of", "resins", "is", "important", "to", "define", "the", "botanical", "origin", "of", "archaeological", "samples", "of", "copal", "." ] } ]
PMC11540664
In conclusion, our study revealed that peripheral blood lymphocyte count is an objective and simple indicator to identify which patients with advanced HCC should receive TKI+PD1 as a first-line systemic therapy rather than TKI alone.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "our", "study", "revealed", "that", "peripheral", "blood", "lymphocyte", "count", "is", "an", "objective", "and", "simple", "indicator", "to", "identify", "which", "patients", "with", "advanced", "HCC", "should", "receive", "TKI+PD1", "as", "a", "first-line", "systemic", "therapy", "rather", "than", "TKI", "alone", "." ] } ]
PMC11473843
Combined genetic or pharmacological inhibition of ERK5 and CDK5 triggered ROS-induced DNA damage and apoptosis in cancer cells and mouse models of KRAS-driven lung adenocarcinoma, recapitulating FAK pharmacological inhibition.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combined", "genetic", "or", "pharmacological", "inhibition", "of", "ERK5", "and", "CDK5", "triggered", "ROS-induced", "DNA", "damage", "and", "apoptosis", "in", "cancer", "cells", "and", "mouse", "models", "of", "KRAS-driven", "lung", "adenocarcinoma", ",", "recapitulating", "FAK", "pharmacological", "inhibition", "." ] } ]
PMC11588008
In this study, we found that HUC-MSCs may regulate the ERK pathway to impact GSH expression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "found", "that", "HUC-MSCs", "may", "regulate", "the", "ERK", "pathway", "to", "impact", "GSH", "expression", "." ] } ]
PMC11727306
The exact cause of GBS is unknown, but it is sometimes triggered after respiratory infections, stomach flu or staphylococcal infections .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exact", "cause", "of", "GBS", "is", "unknown", ",", "but", "it", "is", "sometimes", "triggered", "after", "respiratory", "infections", ",", "stomach", "flu", "or", "staphylococcal", "infections", "." ] } ]
PMC11767725
Oral administration of probiotics has been linked to reduced systemic inflammation and oxidative stress, factors that exacerbate acne severity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Oral", "administration", "of", "probiotics", "has", "been", "linked", "to", "reduced", "systemic", "inflammation", "and", "oxidative", "stress", ",", "factors", "that", "exacerbate", "acne", "severity", "." ] } ]
PMC11653533
Comprehensive double-blind, placebo-controlled clinical trials are essential to validate the efficacy and safety of Ficus-based therapies in larger patient populations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comprehensive", "double-blind", ",", "placebo-controlled", "clinical", "trials", "are", "essential", "to", "validate", "the", "efficacy", "and", "safety", "of", "Ficus-based", "therapies", "in", "larger", "patient", "populations", "." ] } ]
PMC11612626
Caliper measurements indicated that co-treatment with compound A and T cells significantly reduced tumor volume compared with the other treatment groups (Supplementary Fig. S8D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Caliper", "measurements", "indicated", "that", "co-treatment", "with", "compound", "A", "and", "T", "cells", "significantly", "reduced", "tumor", "volume", "compared", "with", "the", "other", "treatment", "groups", "(", "Supplementary", "Fig.", "S8D", ")", "." ] } ]
PMC10291556
For this purpose, cells were treated with concentrations of Pt-complexes that have been shown not to reduce the level of COX-2 protein (IC50,72h, Figure 5B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "this", "purpose", ",", "cells", "were", "treated", "with", "concentrations", "of", "Pt-complexes", "that", "have", "been", "shown", "not", "to", "reduce", "the", "level", "of", "COX-2", "protein", "(", "IC50,72h", ",", "Figure", "5B", ")", "." ] } ]
PMC11740207
Most HGP data was derived from the peripheral blood lymphocytes of anonymous donors, serving as a representative human reference genome.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "HGP", "data", "was", "derived", "from", "the", "peripheral", "blood", "lymphocytes", "of", "anonymous", "donors", ",", "serving", "as", "a", "representative", "human", "reference", "genome", "." ] } ]
PMC9429973
To the best of our knowledge, this is the first evidence in the context of the pathological role of DIS3 in MM.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "the", "best", "of", "our", "knowledge", ",", "this", "is", "the", "first", "evidence", "in", "the", "context", "of", "the", "pathological", "role", "of", "DIS3", "in", "MM", "." ] } ]
PMC9351137
DAPI staining is shown in blue, α-tubulin in green.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "DAPI", "staining", "is", "shown", "in", "blue", ",", "α-tubulin", "in", "green", "." ] } ]
PMC9545474
Untreated cells were used as a negative control, and cells treated with cisplatin were used as a positive control.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Untreated", "cells", "were", "used", "as", "a", "negative", "control", ",", "and", "cells", "treated", "with", "cisplatin", "were", "used", "as", "a", "positive", "control", "." ] } ]
PMC9429973
Median follow up time for the entire study cohort was 36.5 months.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "follow", "up", "time", "for", "the", "entire", "study", "cohort", "was", "36.5", "months", "." ] } ]
PMC10900886
Flow cytometry was performed using BD FACS Lyric (BD Biosciences, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "was", "performed", "using", "BD", "FACS", "Lyric", "(", "BD", "Biosciences", ",", "USA", ")", "." ] } ]
PMC8751435
GSDME will be valuable target for refining CME as dietary therapy, and likewise, upstream regulation of GSDME is worth exploring as well.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSDME", "will", "be", "valuable", "target", "for", "refining", "CME", "as", "dietary", "therapy", ",", "and", "likewise", ",", "upstream", "regulation", "of", "GSDME", "is", "worth", "exploring", "as", "well", "." ] } ]
PMC11477621
Starting from ethyl 8-bromooctanoate (1e) (379 mg, 1.51 mmol) and 2-acetyl pyrrole (137 mg, 1.26 mmol), the title compound was obtained following the procedure previously described for compound 2a.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Starting", "from", "ethyl", "8-bromooctanoate", "(", "1e", ")", "(", "379", "mg", ",", "1.51", "mmol", ")", "and", "2-acetyl", "pyrrole", "(", "137", "mg", ",", "1.26", "mmol", ")", ",", "the", "title", "compound", "was", "obtained", "following", "the", "procedure", "previously", "described", "for", "compound", "2a", "." ] } ]
PMC11638764
RPMI1640 containing 5% FBS and 1% Penicillin-Streptomycin was used as cell viability assay medium.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RPMI1640", "containing", "5", "%", "FBS", "and", "1", "%", "Penicillin-Streptomycin", "was", "used", "as", "cell", "viability", "assay", "medium", "." ] } ]
PMC9429973
Summary/Conclusion: This real-life investigation shows that ponatinib dose reductions were mainly performed in the absence of reported toxicity rather than owing to the occurrence of adverse reactions.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "This", "real-life", "investigation", "shows", "that", "ponatinib", "dose", "reductions", "were", "mainly", "performed", "in", "the", "absence", "of", "reported", "toxicity", "rather", "than", "owing", "to", "the", "occurrence", "of", "adverse", "reactions", "." ] } ]
PMC11023271
A: RIPK4 was knocked down by two shRNAs in HaCaT cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "A", ":", "RIPK4", "was", "knocked", "down", "by", "two", "shRNAs", "in", "HaCaT", "cells", "." ] } ]
PMC9429973
J. Petiti, F. Itri, C. Fava, D. Cilloni Dept.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "J.", "Petiti", ",", "F.", "Itri", ",", "C.", "Fava", ",", "D.", "Cilloni", "Dept", "." ] } ]
PMC9429973
We evaluated the frequencies of germline ATM variants in different hematologic neoplasms.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "evaluated", "the", "frequencies", "of", "germline", "ATM", "variants", "in", "different", "hematologic", "neoplasms", "." ] } ]
PMC9429973
Notably, 80% of SF3B1nent showed AML transformations in comparison to 20% of SF3B1ent (median follow-up: 122 and 112 months).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "80", "%", "of", "SF3B1nent", "showed", "AML", "transformations", "in", "comparison", "to", "20", "%", "of", "SF3B1ent", "(", "median", "follow-up", ":", "122", "and", "112", "months", ")", "." ] } ]
PMC9429973
Aims: We performed a prospective, observational study assessing for hypercoagulability, endotheliopathy and inflammation in recovered COVID-19 patients beyond 6 months of recovery.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "We", "performed", "a", "prospective", ",", "observational", "study", "assessing", "for", "hypercoagulability", ",", "endotheliopathy", "and", "inflammation", "in", "recovered", "COVID-19", "patients", "beyond", "6", "months", "of", "recovery", "." ] } ]
PMC9429973
The primary endpoints are safety and maximum tolerated dose (Phase 1a) and objective response rate (Phase 1b) of NX-1607.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "endpoints", "are", "safety", "and", "maximum", "tolerated", "dose", "(", "Phase", "1a", ")", "and", "objective", "response", "rate", "(", "Phase", "1b", ")", "of", "NX-1607", "." ] } ]
PMC11317131
PE optimization and PhiC31 integrase targeted insertion into the human genome. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PE", "optimization", "and", "PhiC31", "integrase", "targeted", "insertion", "into", "the", "human", "genome", ".", "(" ] } ]
PMC11742670
To overcome these limitations, engineered craft by implementation of Artificial Intelligence (AI) tools is more accurate, faster, and affordable cost.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "overcome", "these", "limitations", ",", "engineered", "craft", "by", "implementation", "of", "Artificial", "Intelligence", "(", "AI", ")", "tools", "is", "more", "accurate", ",", "faster", ",", "and", "affordable", "cost", "." ] } ]
PMC11365427
Bone parameters were then calculated using Inveon Research Workplace software, which included bone density parameters and bone structure parameters.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bone", "parameters", "were", "then", "calculated", "using", "Inveon", "Research", "Workplace", "software", ",", "which", "included", "bone", "density", "parameters", "and", "bone", "structure", "parameters", "." ] } ]
PMC11803149
Age-associated defects in T cell-mediated immunity can increase the risk of cancers, but how aging influences adoptive T-cell therapy (ACT) for cancers remains unclear.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Age-associated", "defects", "in", "T", "cell-mediated", "immunity", "can", "increase", "the", "risk", "of", "cancers", ",", "but", "how", "aging", "influences", "adoptive", "T-cell", "therapy", "(", "ACT", ")", "for", "cancers", "remains", "unclear", "." ] } ]
PMC7154001
The primary enzyme system involved in phase I metabolism is cytochrome P450 (CYP), and the major enzymes involved in phase II are UDP-glucuronosyltransferase (UGT), sulfotransferase (SULT), glutathione-S-transferase (GST), N-acetyltransferase (NAT), and methyltransferase (MT).12 Drug metabolism plays a crucial role in determining the efficiency and safety of drugs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "enzyme", "system", "involved", "in", "phase", "I", "metabolism", "is", "cytochrome", "P450", "(", "CYP", ")", ",", "and", "the", "major", "enzymes", "involved", "in", "phase", "II", "are", "UDP-glucuronosyltransferase", "(", "UGT", ")", ",", "sulfotransferase", "(", "SULT", ")", ",", "glutathione-S-transferase", "(", "GST", ")", ",", "N-acetyltransferase", "(", "NAT", ")", ",", "and", "methyltransferase", "(MT).12", "Drug", "metabolism", "plays", "a", "crucial", "role", "in", "determining", "the", "efficiency", "and", "safety", "of", "drugs", "." ] } ]
PMC11766309
HEK cells were maintained in a DMEM/F12K medium.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HEK", "cells", "were", "maintained", "in", "a", "DMEM/F12", "K", "medium", "." ] } ]
PMC9429973
These aberrations had not been described before in pediatric AML.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "aberrations", "had", "not", "been", "described", "before", "in", "pediatric", "AML", "." ] } ]
PMC4443654
Accurate models of higher-order chromatin state built from locus-level features.(A) Model predictions (Predicted eig) are compared to observed values (Empirical eig).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accurate", "models", "of", "higher-order", "chromatin", "state", "built", "from", "locus-level", "features.(A", ")", "Model", "predictions", "(", "Predicted", "eig", ")", "are", "compared", "to", "observed", "values", "(", "Empirical", "eig", ")", "." ] } ]
PMC11541409
HK inhibitor (3-bromopyruvate) and LDHA inhibitor gossypol effectively inhibited glycolysis, reduced cell viability and induced apoptosis .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HK", "inhibitor", "(", "3-bromopyruvate", ")", "and", "LDHA", "inhibitor", "gossypol", "effectively", "inhibited", "glycolysis", ",", "reduced", "cell", "viability", "and", "induced", "apoptosis", "." ] } ]
PMC10329074
Additionally, YBX3 activation of Kirsten rat sarcoma viral oncogenes attenuated breast cancer progression (Qin et al. 2021).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "YBX3", "activation", "of", "Kirsten", "rat", "sarcoma", "viral", "oncogenes", "attenuated", "breast", "cancer", "progression", "(", "Qin", "et", "al.", "2021", ")", "." ] } ]
PMC11467800
We first stained the K562 cells with fluorescent dye and treated with 20 μM (high dose), 5 μM (clinical median peak plasma concentration) and 0 μM IM in cell culture.
[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "first", "stained", "the", "K562", "cells", "with", "fluorescent", "dye", "and", "treated", "with", "20", "μM", "(", "high", "dose", ")", ",", "5", "μM", "(", "clinical", "median", "peak", "plasma", "concentration", ")", "and", "0", "μM", "IM", "in", "cell", "culture", "." ] } ]
PMC11774747
Moreover, CAR-VSTs may provide additional regulatory and safety benefits compared to TCR knockdown strategies using CRISPR-Cas9 or other gene modification techniques, as these approaches carry a potentially increased risk of genotoxicity and malignant transformation (79, 80).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "CAR-VSTs", "may", "provide", "additional", "regulatory", "and", "safety", "benefits", "compared", "to", "TCR", "knockdown", "strategies", "using", "CRISPR-Cas9", "or", "other", "gene", "modification", "techniques", ",", "as", "these", "approaches", "carry", "a", "potentially", "increased", "risk", "of", "genotoxicity", "and", "malignant", "transformation", "(", "79", ",", "80", ")", "." ] } ]
PMC11746942
Scale bars: 50 μm.
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ":", "50", "μm", "." ] } ]
PMC11265931
Human hepatoma (Hep3B), human neuroblastoma (SH-SY5Y), human pancreatic adenocarcinoma (Panc-1a), human glioblastoma (U87), prostate cancer (PC-3), and human umbilical vein endothelial (HUVEC) cell lines were treated with garlic SEVs to examine their anticancer properties.
[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "hepatoma", "(", "Hep3B", ")", ",", "human", "neuroblastoma", "(", "SH-SY5Y", ")", ",", "human", "pancreatic", "adenocarcinoma", "(", "Panc-1a", ")", ",", "human", "glioblastoma", "(", "U87", ")", ",", "prostate", "cancer", "(", "PC-3", ")", ",", "and", "human", "umbilical", "vein", "endothelial", "(", "HUVEC", ")", "cell", "lines", "were", "treated", "with", "garlic", "SEVs", "to", "examine", "their", "anticancer", "properties", "." ] } ]
PMC9592219
The TOP2A expression levels in T3 and T4 samples were higher than those in T1 and T2 samples (Figure S2D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "TOP2A", "expression", "levels", "in", "T3", "and", "T4", "samples", "were", "higher", "than", "those", "in", "T1", "and", "T2", "samples", "(", "Figure", "S2D", ")", "." ] } ]
PMC11321678
This information was used to construct a directed TF regulatory network using the R package igraph, where each vertex represents a TF or target gene, and each edge represents a putative regulate event.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "information", "was", "used", "to", "construct", "a", "directed", "TF", "regulatory", "network", "using", "the", "R", "package", "igraph", ",", "where", "each", "vertex", "represents", "a", "TF", "or", "target", "gene", ",", "and", "each", "edge", "represents", "a", "putative", "regulate", "event", "." ] } ]
PMC11535726
In this study, we introduce three novel Kirschsteiniothelia species (K.bulbosapicalis, K.dendryphioides and K.longirostrata) and describe a new host record for K.atra, based on morphology and multi-gene phylogenetic analyses of a concatenated ITS, LSU and SSU rDNA sequence data.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "introduce", "three", "novel", "Kirschsteiniothelia", "species", "(", "K.bulbosapicalis", ",", "K.dendryphioides", "and", "K.longirostrata", ")", "and", "describe", "a", "new", "host", "record", "for", "K.atra", ",", "based", "on", "morphology", "and", "multi-gene", "phylogenetic", "analyses", "of", "a", "concatenated", "ITS", ",", "LSU", "and", "SSU", "rDNA", "sequence", "data", "." ] } ]
PMC11528603
When interacting with PCNA, p21 blocks its activity, therefore inhibiting DNA replication.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "interacting", "with", "PCNA", ",", "p21", "blocks", "its", "activity", ",", "therefore", "inhibiting", "DNA", "replication", "." ] } ]
PMC11696659
This was reflected in a lower proportion of long telomeres, in the overall distribution of telomere lengths, and in the overrepresentation of short telomeres over long telomeres in these patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was", "reflected", "in", "a", "lower", "proportion", "of", "long", "telomeres", ",", "in", "the", "overall", "distribution", "of", "telomere", "lengths", ",", "and", "in", "the", "overrepresentation", "of", "short", "telomeres", "over", "long", "telomeres", "in", "these", "patients", "." ] } ]
PMC10197932
Under 2T sonication treatments, all myeloid leukemia cells undergo apoptosis/necrosis events.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Under", "2", "T", "sonication", "treatments", ",", "all", "myeloid", "leukemia", "cells", "undergo", "apoptosis/necrosis", "events", "." ] } ]
PMC10094712
Protein expression was quantified using ImageJ software (Java 1.6.0_12, RRID: SCR_003070, LOCI, University of Wisconsin, Madison, WI, USA).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "expression", "was", "quantified", "using", "ImageJ", "software", "(", "Java", "1.6.0_12", ",", "RRID", ":", "SCR_003070", ",", "LOCI", ",", "University", "of", "Wisconsin", ",", "Madison", ",", "WI", ",", "USA", ")", "." ] } ]
PMC6799808
Having observed GLPT-induced apoptosis in lung cancer cells (Fig. 1f, g), we wondered whether this apoptosis was caspase-dependent.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Having", "observed", "GLPT-induced", "apoptosis", "in", "lung", "cancer", "cells", "(", "Fig.", "1f", ",", "g", ")", ",", "we", "wondered", "whether", "this", "apoptosis", "was", "caspase-dependent", "." ] } ]
PMC9622879
where is the selling profit (or energy cost) which all selling homes receive from all buying homes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "where", "is", "the", "selling", "profit", "(", "or", "energy", "cost", ")", "which", "all", "selling", "homes", "receive", "from", "all", "buying", "homes", "." ] } ]
PMC11713679
Given the multifactorial nature of AD, therapeutic strategies need to focus on disease‐specific biochemical pathways.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Given", "the", "multifactorial", "nature", "of", "AD", ",", "therapeutic", "strategies", "need", "to", "focus", "on", "disease‐specific", "biochemical", "pathways", "." ] } ]
PMC11718817
The detection reagent of the CellEvent™ Caspase-3/7 kit (Invitrogen, catalog no. C10430) consists of a nucleic acid binding dye conjugated to a four amino acid peptide (DEVD).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "detection", "reagent", "of", "the", "CellEvent", "™", "Caspase-3/7", "kit", "(", "Invitrogen", ",", "catalog", "no.", "C10430", ")", "consists", "of", "a", "nucleic", "acid", "binding", "dye", "conjugated", "to", "a", "four", "amino", "acid", "peptide", "(", "DEVD", ")", "." ] } ]
PMC10728200
The dosages of IM and RSL3 were determined based on previous studies and our own preliminary experimental results.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dosages", "of", "IM", "and", "RSL3", "were", "determined", "based", "on", "previous", "studies", "and", "our", "own", "preliminary", "experimental", "results", "." ] } ]
PMC11502327
Studies have shown that 32% of small-molecule drugs approved globally in the last 40 years were derived from natural products and their derivatives (6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Studies", "have", "shown", "that", "32", "%", "of", "small-molecule", "drugs", "approved", "globally", "in", "the", "last", "40", "years", "were", "derived", "from", "natural", "products", "and", "their", "derivatives", "(", "6", ")", "." ] } ]
PMC11066331
Heat map with hierarchical clustering analysis (Ward metric) of the 75 m/z signals (C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heat", "map", "with", "hierarchical", "clustering", "analysis", "(", "Ward", "metric", ")", "of", "the", "75", "m/z", "signals", "(", "C", ")", "." ] } ]
PMC9429973
In the overall population (n=80), FTF was significantly associated with reason for switch to ASC (p=0.006), and there was a trend toward association of FTF with disease phase (p=0.08) and ponatinib therapy (p=0.12), but not with ABL1 kinase domain mutation (p=0.402), additional cytogenetic abnormality (p=0.908), nor cardiovascular risk profile (p=0.345).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "overall", "population", "(", "n=80", ")", ",", "FTF", "was", "significantly", "associated", "with", "reason", "for", "switch", "to", "ASC", "(", "p=0.006", ")", ",", "and", "there", "was", "a", "trend", "toward", "association", "of", "FTF", "with", "disease", "phase", "(", "p=0.08", ")", "and", "ponatinib", "therapy", "(", "p=0.12", ")", ",", "but", "not", "with", "ABL1", "kinase", "domain", "mutation", "(", "p=0.402", ")", ",", "additional", "cytogenetic", "abnormality", "(", "p=0.908", ")", ",", "nor", "cardiovascular", "risk", "profile", "(", "p=0.345", ")", "." ] } ]
PMC11506670
To assess the reproducibility of the observed results in a model that approximates the spatial organization of tumor cells, HCT116 cells transfected with constructs of the NRAS mutants, along with the wild-type, vector-only, and NRAS Q61K canonical mutant controls, were cultured as 3D spheroids.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "assess", "the", "reproducibility", "of", "the", "observed", "results", "in", "a", "model", "that", "approximates", "the", "spatial", "organization", "of", "tumor", "cells", ",", "HCT116", "cells", "transfected", "with", "constructs", "of", "the", "NRAS", "mutants", ",", "along", "with", "the", "wild-type", ",", "vector-only", ",", "and", "NRAS", "Q61", "K", "canonical", "mutant", "controls", ",", "were", "cultured", "as", "3D", "spheroids", "." ] } ]
PMC11519788
GSEA further revealed a significant correlation between SPOP loss and STAT3 activation, which is involved in both cancer stemness and immune regulation (Figure 4C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSEA", "further", "revealed", "a", "significant", "correlation", "between", "SPOP", "loss", "and", "STAT3", "activation", ",", "which", "is", "involved", "in", "both", "cancer", "stemness", "and", "immune", "regulation", "(", "Figure", "4C", ")", "." ] } ]
PMC9429973
Derived response was defined as 2017 ELN response based on bone marrow findings and complete blood count (CBC) results available in the EHR.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Derived", "response", "was", "defined", "as", "2017", "ELN", "response", "based", "on", "bone", "marrow", "findings", "and", "complete", "blood", "count", "(", "CBC", ")", "results", "available", "in", "the", "EHR", "." ] } ]
PMC9046263
However, HML6 expression was an order of magnitude higher in A172 relative to expression in M059J (B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "HML6", "expression", "was", "an", "order", "of", "magnitude", "higher", "in", "A172", "relative", "to", "expression", "in", "M059J", "(", "B", ")", "." ] } ]
PMC6600253
LY2603618 is a selective and potent ATP-competitive CHK1 inhibitor.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LY2603618", "is", "a", "selective", "and", "potent", "ATP-competitive", "CHK1", "inhibitor", "." ] } ]
PMC9429973
Daratumumab, a monoclonal kappa chain antibody against CD38 is routinely used in multiple myeloma treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Daratumumab", ",", "a", "monoclonal", "kappa", "chain", "antibody", "against", "CD38", "is", "routinely", "used", "in", "multiple", "myeloma", "treatment", "." ] } ]
PMC11224020
NF-κB (P65) is in gray, and nuclei are in red; scale bar, 10 µm; Gaussian blur of 0.5 µm.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NF-κB", "(", "P65", ")", "is", "in", "gray", ",", "and", "nuclei", "are", "in", "red", ";", "scale", "bar", ",", "10", "µm", ";", "Gaussian", "blur", "of", "0.5", "µm", "." ] } ]
PMC11469524
PI3K inhibitor was chosen as it represents a central hub in the deduced network model with mTORC1 the target of rapamycin being a major downstream mediator, whereas the p38 inhibition was included to get an unbiased insight into the downstream effects of p38 in BCR signaling as well as to extend the understanding of the p38-MEK/ERK crosstalk in B cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PI3", "K", "inhibitor", "was", "chosen", "as", "it", "represents", "a", "central", "hub", "in", "the", "deduced", "network", "model", "with", "mTORC1", "the", "target", "of", "rapamycin", "being", "a", "major", "downstream", "mediator", ",", "whereas", "the", "p38", "inhibition", "was", "included", "to", "get", "an", "unbiased", "insight", "into", "the", "downstream", "effects", "of", "p38", "in", "BCR", "signaling", "as", "well", "as", "to", "extend", "the", "understanding", "of", "the", "p38-MEK/ERK", "crosstalk", "in", "B", "cells", "." ] } ]
PMC9611901
Available literature reports indicate that these compounds can cause primary DNA damage.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Available", "literature", "reports", "indicate", "that", "these", "compounds", "can", "cause", "primary", "DNA", "damage", "." ] } ]
PMC9429973
Results: Most of the immunophenotypic markers in our flow cytometry panel showed homogeneous expression patterns in KG1a cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Results", ":", "Most", "of", "the", "immunophenotypic", "markers", "in", "our", "flow", "cytometry", "panel", "showed", "homogeneous", "expression", "patterns", "in", "KG1a", "cells", "." ] } ]
PMC11473843
The PTK2 point mutants sequences were designed and ordered from GenScript, amplified and cloned into pWZL-Hygro using the sequence- and ligation-independent cloning (SLIC) method (Li and Elledge, 2012).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PTK2", "point", "mutants", "sequences", "were", "designed", "and", "ordered", "from", "GenScript", ",", "amplified", "and", "cloned", "into", "pWZL-Hygro", "using", "the", "sequence-", "and", "ligation-independent", "cloning", "(", "SLIC", ")", "method", "(", "Li", "and", "Elledge", ",", "2012", ")", "." ] } ]
PMC9429973
The primary objective of the study is to determine independently for each cohort/indication, the optimal biological dose (OBD)/ recommended Phase 2 dose (RP2D) of BMF-219 oral monotherapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "objective", "of", "the", "study", "is", "to", "determine", "independently", "for", "each", "cohort/indication", ",", "the", "optimal", "biological", "dose", "(OBD)/", "recommended", "Phase", "2", "dose", "(", "RP2D", ")", "of", "BMF-219", "oral", "monotherapy", "." ] } ]
PMC11335267
Dysfunction of any of these mechanisms frequently results in two of the most common metabolic disorders, obesity, and diabetes, which in turn trigger the development of important complications.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dysfunction", "of", "any", "of", "these", "mechanisms", "frequently", "results", "in", "two", "of", "the", "most", "common", "metabolic", "disorders", ",", "obesity", ",", "and", "diabetes", ",", "which", "in", "turn", "trigger", "the", "development", "of", "important", "complications", "." ] } ]
PMC11394730
In addition, According to reports, anthocyanins have the ability to regulate the expression and secretion of inflammatory factors by blocking the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) via a variety of mechanisms .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "According", "to", "reports", ",", "anthocyanins", "have", "the", "ability", "to", "regulate", "the", "expression", "and", "secretion", "of", "inflammatory", "factors", "by", "blocking", "the", "transcription", "factor", "nuclear", "factor", "kappa-light-chain-enhancer", "of", "activated", "B", "cells", "(", "NF-κB", ")", "via", "a", "variety", "of", "mechanisms", "." ] } ]
PMC11026382
By quantifying the change in the relative frequency of individual mutants over time with next generation sequencing, we obtained a growth rate difference relative to WT DHFR for nearly all mutations in the library (Fig. 3a, Supplementary Data 1, see methods for details).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "By", "quantifying", "the", "change", "in", "the", "relative", "frequency", "of", "individual", "mutants", "over", "time", "with", "next", "generation", "sequencing", ",", "we", "obtained", "a", "growth", "rate", "difference", "relative", "to", "WT", "DHFR", "for", "nearly", "all", "mutations", "in", "the", "library", "(", "Fig.", "3a", ",", "Supplementary", "Data", "1", ",", "see", "methods", "for", "details", ")", "." ] } ]
PMC10024132
Blinatumomab is the first T cell-engaging bsAb in clinical use and is approved to treat patients with relapsed and refractory B cell-acute lymphoblastic leukemia (ALL) , , .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blinatumomab", "is", "the", "first", "T", "cell-engaging", "bsAb", "in", "clinical", "use", "and", "is", "approved", "to", "treat", "patients", "with", "relapsed", "and", "refractory", "B", "cell-acute", "lymphoblastic", "leukemia", "(", "ALL", ")", ",", ",", "." ] } ]
PMC11657695
Proliferation and cell count assessment were performed using cell biology approaches.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Proliferation", "and", "cell", "count", "assessment", "were", "performed", "using", "cell", "biology", "approaches", "." ] } ]
PMC5925824
The absolute number of T cells and CD4+ and CD8+ subsets were calculated based on relative beads collected compared to total number provide by manufacturer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "absolute", "number", "of", "T", "cells", "and", "CD4", "+", "and", "CD8", "+", "subsets", "were", "calculated", "based", "on", "relative", "beads", "collected", "compared", "to", "total", "number", "provide", "by", "manufacturer", "." ] } ]
PMC8540692
Since the gene expression changes observed in our study were not caused by complete promoter demethylation, we wanted to verify, if the analyzed compounds had an impact on the key epigenetic regulator—UHRF1 (ubiquitin-like with plant homeodomain and really interesting new gene finger domain 1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "the", "gene", "expression", "changes", "observed", "in", "our", "study", "were", "not", "caused", "by", "complete", "promoter", "demethylation", ",", "we", "wanted", "to", "verify", ",", "if", "the", "analyzed", "compounds", "had", "an", "impact", "on", "the", "key", "epigenetic", "regulator", "—", "UHRF1", "(", "ubiquitin-like", "with", "plant", "homeodomain", "and", "really", "interesting", "new", "gene", "finger", "domain", "1", ")", "." ] } ]
PMC9878278
p < 0.05; **p < 0.01.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05", ";", "*", "*", "p", "<", "0.01", "." ] } ]
PMC11792888
Therefore, the release of cleaved AIF results from mitochondrial membrane potential destabilization, leading to mitochondrial outer membrane permeabilization, loss of mitochondrial function, and ultimately causing DNA degradation during apoptotic cell death.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "release", "of", "cleaved", "AIF", "results", "from", "mitochondrial", "membrane", "potential", "destabilization", ",", "leading", "to", "mitochondrial", "outer", "membrane", "permeabilization", ",", "loss", "of", "mitochondrial", "function", ",", "and", "ultimately", "causing", "DNA", "degradation", "during", "apoptotic", "cell", "death", "." ] } ]
PMC7887261
The color vertical bars represent different types of variants: ClinVar pathogenic variants (bold blue: POMC W84* stop-gain, ATM Q414* stop-gain, and MPZL2 M1T* start-loss), previous reported LC-associated variants (blue: ATM P1054R and L2307F, and MPZL2 deletion rs13915729), and ClinVar variants of uncertain significance (black).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "color", "vertical", "bars", "represent", "different", "types", "of", "variants", ":", "ClinVar", "pathogenic", "variants", "(", "bold", "blue", ":", "POMC", "W84", "*", "stop-gain", ",", "ATM", "Q414", "*", "stop-gain", ",", "and", "MPZL2", "M1", "T", "*", "start-loss", ")", ",", "previous", "reported", "LC-associated", "variants", "(", "blue", ":", "ATM", "P1054R", "and", "L2307F", ",", "and", "MPZL2", "deletion", "rs13915729", ")", ",", "and", "ClinVar", "variants", "of", "uncertain", "significance", "(", "black", ")", "." ] } ]
PMC9429973
Nevertheless, there was a 5.9-fold (95% CI 2.8–10.8) increased risk of Multiple Myeloma (MM).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "there", "was", "a", "5.9-fold", "(", "95", "%", "CI", "2.8–10.8", ")", "increased", "risk", "of", "Multiple", "Myeloma", "(", "MM", ")", "." ] } ]
PMC11648299
The comorbidities of patients with DD included schizophrenia, hypothyroidism (three patients), heart failure and type I diabetes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "comorbidities", "of", "patients", "with", "DD", "included", "schizophrenia", ",", "hypothyroidism", "(", "three", "patients", ")", ",", "heart", "failure", "and", "type", "I", "diabetes", "." ] } ]
PMC6934009
It has been recognized that ROS serves as an anti-tumor molecule (6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "recognized", "that", "ROS", "serves", "as", "an", "anti-tumor", "molecule", "(", "6", ")", "." ] } ]
PMC10734950
The cells were incubated for 8 h and stained with NucView 488 caspase-3/7 substrate.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "incubated", "for", "8", "h", "and", "stained", "with", "NucView", "488", "caspase-3/7", "substrate", "." ] } ]
PMC9429973
Consortium Program and performed clinical, immunohistochemical, and genetic analyses with a focus on cyclin D1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consortium", "Program", "and", "performed", "clinical", ",", "immunohistochemical", ",", "and", "genetic", "analyses", "with", "a", "focus", "on", "cyclin", "D1", "." ] } ]
PMC11300639
g A498 cells were transfected with indicated plasmids for 48 h and subjected to western blotting analysis.
[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "A498", "cells", "were", "transfected", "with", "indicated", "plasmids", "for", "48", "h", "and", "subjected", "to", "western", "blotting", "analysis", "." ] } ]
PMC11656657
H The 143B wild-type control (dark grey), 143B CXCL8 (white), 143B G-CSF (light gray) cells were co-cultured for 5 days with NT or GD2.CAR T-cells at E: T = 1:1 ratio.
[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "The", "143B", "wild-type", "control", "(", "dark", "grey", ")", ",", "143B", "CXCL8", "(", "white", ")", ",", "143B", "G-CSF", "(", "light", "gray", ")", "cells", "were", "co-cultured", "for", "5", "days", "with", "NT", "or", "GD2.CAR", "T-cells", "at", "E", ":", "T", "=", "1:1", "ratio", "." ] } ]
PMC9429973
Induction of the iMLL-AF9 fusion did not result in significant changes in numbers of Evi1+ cells nor levels of Evi1 mRNA expression in the LT-HSC and MPP1 compartments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Induction", "of", "the", "iMLL-AF9", "fusion", "did", "not", "result", "in", "significant", "changes", "in", "numbers", "of", "Evi1", "+", "cells", "nor", "levels", "of", "Evi1", "mRNA", "expression", "in", "the", "LT-HSC", "and", "MPP1", "compartments", "." ] } ]