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OTAR3088
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BioData-CellLine_annotated

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PMC11626627
The survival analysis data were obtained from Kaplan-Meier plotter (https://kmplot.com, accessed on 15 July 2022).
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PMC11451940
calcd. (%)
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PMC8759873
In recent years, ultrasound has attracted much attention.
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PMC10938377
X-ray crystallographic analysis was conducted using NCP assembled with recombinant Homo sapiens histones and a 145 bp DNA fragment.
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PMC9105697
Calculations showed a correlation coefficient of 0.55 with a p value of 0.0276.
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PMC9429973
Disease-related complications related to β-thal were experienced by all patients (total 1089 [median 5 (range, 1–21)]; 22.1% were Grade ≥3).
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PMC11740907
To dissolve the cells, the slides were submerged in a pH-10 lysis solution.
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PMC11699465
The symbol ∗ indicates p < 0.05; ∗∗ indicates p < 0.01; ∗∗∗indicates p < 0.001.
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PMC11538390
Supporting this conclusion, the rs570516915 variant shows a significant association with CP alone, while rs642961 is strongly associated with CL and modestly associated with CLP.
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PMC11612315
Among the exendin 9–39 fragments, exendin 20–29 specifically binds to TRPV1, alleviating pain in both acute and chronic pain models without interfering with GLP-1R function.
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PMC11377827
Alternatively, 14-3-3 proteins may assist with the nuclear translocation due to their ability to enable free shuttling between the nucleus and cytoplasm (Brunet et al, 2002), or through ligand binding.
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PMC11756937
When Versene was used, 2 mL of growth medium was added for a wash.
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PMC11063646
Andrographolide concentration in emulgel was measured by UV spectrophotometer.
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PMC9429973
Patients were considered as fit when CIRS(cumulative illness rating skill) was inferior to six.
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PMC9926039
The interaction between methadone and active site of toll-like receptor 4 and MD-2 visualized by Discovery Studio 2016 In the current study, a significant increase in the level of TLR4 expression was observed in the methadone-treated A549 cells.
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PMC10589262
One-way ANOVA with a post-hoc test was performed to compare multiple means (*p < 0.05, **p < 0.01, ***p < 0.001).
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PMC11599565
However, it remains unclear whether the acquisition of neuroepithelial features in OC corresponds to more aggressive tumor types or persistent chemotherapy refraction of dormant OC cells.
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PMC11462673
2 × 10 cells were incubated with cold Nuclear Extract Buffer for 10 min.
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PMC9541067
f–h Quantitative description to (e) and (g).
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PMC7185206
Flow cytometry of extracellular vesicles (EVs) was performed on isolated supernatants from cell culture.
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PMC11190538
As a result, C-phycocyanin did not influence starting culture development.
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PMC9429973
Costs were obtained from a Canadian public health payer’s perspective (CAN$1=US$0.78) and inflation-adjusted for 2022.
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PMC6034753
The CtBP and BZIP-domains are not involved in interaction with apoptin.
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PMC8609870
Additionally, the cell component (CC) changes of DELs were obviously enriched in transcription factor complex, axon part, postsynaptic specialization, histone methyltransferase complex, clathrin-coated pit, MLL1/2 complex, hemoglobin complex, MLL1 complex, haptoglobin-hemoglobin complex and exocyst.
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PMC11611077
Average cell area.
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PMC9681981
The PCR results of cpa, etx, and 16S rRNA genes were shown in Fig. 4.
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PMC11453018
Gene expression analyses revealed a significant upregulation of PI3K, mTOR, MCL-1, and ERBB2, and a reduction of BCL-2 and SRC2 (Fig. 5E).
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PMC9429973
All grades CRS occurred in 89%, including ≥grade 3 in 2.7%, median time to onset was 3 days (min-max 0-14) and median duration 6 days (min-max 1-17).
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PMC11732628
Osteosarcoma cells are characterized by high drug resistance and metastasis, which are clinically considered as the leading cause of recurrence and distant metastasis in patients with osteosarcoma (17).
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PMC9031474
Especially, the cinnamoyl derivatives 18 and 19 exhibited increased cytotoxic activities.
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PMC11612626
NuPAGE MES SDS running buffer (Invitrogen, #NP0002) was used for resolving small- to medium-sized proteins and NuPAGE MOPS SDS running buffer (Invitrogen, #NP0001) used to resolve medium-large–sized proteins.
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PMC5941560
The damaged genes affecting T-cell receptor signaling are PTEN, INPP5D, CTLA4, and SYK.
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PMC9014716
Total RNA was collected for quantitative real-time polymerase chain reaction (qRT-PCR) analysis and the protein content was collected for western blot analysis.
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PMC2944824
Thapsigargin and tunicamycin induce apoptosis by stressing the ER whereas staurosporine induces apoptosis by acting directly on the mitochondria .
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PMC11171319
Recently our group reported that human astrocytes chronically infected and transformed by oncogenic HR-HCMV strains (HCMV-DB strain and HCMV strains isolated from glioblastoma patients) generated spheroids that resulted in the appearance of glioblastoma-like tumors in xenografted mice .
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PMC9429973
BM fibrosis improvement by ≥1 grade was achieved in 31% (16/52) and 25% (9/36) pts in Arm 3 and 2, respectively.
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PMC11634027
Quantifications for western blots are presented as mean±s.e.m.
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PMC11705630
Further studies to develop a specific inhibitor of GLDC are also necessary.
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PMC11594641
The RAB27A/B double knockout moderately decreased the migratory capacity of A375 cells without disturbing their invasiveness.
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PMC10582049
The results of our research show that ADH1B CAFs correlate with LUAD behavior and can be used for the prediction of tumor aggressiveness at an early stage.
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PMC11794568
Cells were then fixed, permeabilized and stained according to the manufacturer’s instructions.
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PMC11320834
Topotecan-related DSBs induce multiple types of DNA damage, and olaparib diminishes the PARP enzyme's ability to repair it.
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PMC11544771
Whether the discrepancy is related to the different concentrations of PRE used needs to be further investigated.
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PMC10024132
This research was funded by Manysmart Therapeutics Inc. C.M.L. is a founder of Manysmart Therapeutics Inc. C.H.L. is an employee and a cofounder of Manysmart Therapeutics Inc. S.J.W. and C.T.L. declare no competing interests.
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PMC11285179
CCL28 significantly increased the migration distance of pericytes compared to the control group (Fig. 2E, right panel).
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PMC11352877
Four subtypes of angiopoietins (ANG1, ANG2, ANG3, and ANG4) have previously been described.
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PMC3888431
Two pipelines to extend and improve the CHO cell line transcripts were established.
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PMC9429973
To ameliorate patients’ outcome there is an urgent need to discover new treatments.
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PMC4485648
There are only few studies on SFN effect in hypoxic cancer cells (11–13).
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PMC11775197
Hence, there is positive feedback between PPARβ/δ, COX-2, and PGE2, which is a key factor in promoting tumorigenesis .
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PMC11185260
N = 4–6/group.
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PMC11496491
The results of this study showed that all samples were qualified.
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PMC9878562
To get a better insight we sorted ACKR3 and ACKR3 VAL cells and analyzed their migratory properties in chemotaxis assays.
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PMC7987994
L929 cell line derived from murine fibroblasts (ATCC CCL-1™) and U-2 OS cell line derived from human osteosarcoma (ATCC HTB-96™) were maintained in MEM (Minimal Essential Medium, Sigma, M0446) and DMEM (Dulbecco’s Modified Eagle’s Medium, Sigma, D0819), respectively with 10% FBS at standard conditions of 37 °C, 5% CO2 ...
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PMC9275501
In vivo antitumor experiments showed that HA-GEM-BCL NLCs had the strongest antitumor effect on pancreatic cancer animals compared with other liposomes, and had less systemic toxicity to tumor treatment in vivo.
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PMC11543853
MgCl2 was added to a final concentration of 5 mM, and the sample was subjected to DNAse (10 μg/mL final concentration) and RNAse (10 μg/mL final concentration) treatment for 30 min at ambient temperature.
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PMC11477621
HRMS (ESI), m/z: calcd for C14H21N2O3: 265.1558 [M − H]; found: 265.1557.
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PMC9429973
Furthermore, RGFP966 exhibited a significant in-vivo antileukemic effect as measured by the burden of disease in the bone marrow of NSG mice transplanted with SKNO1 cells.
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PMC11705862
Our immunofluorescent staining revealed some colocalization between IRIS-1 and 2 and the astrocyte marker GFAP, evident as white puncta (Fig. 1E, F).
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PMC2118063
Genechips were scanned on a high-resolution Affymetrix scanner using GCOS software (version 1.2).
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PMC9429973
3D imaging of cleared organoids was performed to analyze invasion.
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PMC9429973
CAN106 exposure (Cmax and AUC) was dose-proportional, linear, and had low inter-subject variability (<20% CV).
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PMC10243817
Concomitantly, we discovered that MEX3B modulated TGF-β2 signaling activation in nasal epithelial cells.
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PMC11476004
In healthy people, the level of DNA damage in the study cited was low—up to 6 (%T DNA).
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PMC10142392
The second stage of degradation was followed by a decrease in crystallinity, as the PCL chains in the copolymers were degraded.
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PMC11548041
These findings show that MNVs functionalized with the EpCAM-binding aptamer PLD01 can be used to generate targeted therapeutic cargo delivery vehicles that retain the ability to deliver functional siRNA to EpCAM-expressing cells.
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PMC11345828
We selected four compounds (25, 26, 27, and 29) to evaluate in dog IV PK studies, that covered a range of mouse PK dispositions and ether structural variety (Table 3).
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PMC9592219
High TOP2A expression is a favorable prognostic factor in colorectal cancer .
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PMC8701144
Chemiluminescent detection was performed with the ECL Prime Western blotting Detection Reagent (Amersham–GE Healthcare, Chicago, IL, USA) and the ChemiDoc Touch Imaging System (Bio-Rad, Hercules, CA, USA).
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PMC8345486
After reaction completion (usually 24 h), the solvent was evaporated under vacuum.
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PMC11297139
Source data are provided as a Source Data file.
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PMC9429973
Importantly, patients with a TKI treatment duration <6 years and a low D-PCR result were found to have a clinically acceptable MolR rate (48%).
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PMC2614416
Digestion was carried out by adding 6 μL of 0.40 μg/μL = 2.4 μg of Promega Sequencing Grade trypsin and incubating in Eppendorf Thermomixer R for 20 hr at 37.4°C.
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PMC9429973
20% of patients were diagnosed with lymphoma within 1 year of AIDS diagnosis and antiviral therapy.
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PMC10955424
Most chemicals were obtained from Sigma Aldrich Israel Ltd. (Rehovot, Israel), otherwise the vendor is specified.
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PMC9822769
In the present paper, the cytotoxic activity in a panel of seven human tumor cell lines, including a cisplatin-resistant subtype, of the three simple cisplatin-based Pt(IV) models 1–3 (Figure 1) is discussed with respect to its lipophilicity, membrane affinity, reduction potentials, and reduction kinetics.
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PMC11470381
B. Background signal correction involves selecting an ROI in the background region, measuring its average intensity, and subtracting the signal from the original image.
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PMC11489175
Thus, ssDNA gap accumulation may be exploited as a biomarker of response to USP1 inhibitors.
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PMC11615828
Prior to bleaching, an initial image was captured to establish a baseline for fluorescence intensity.
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PMC6182045
Additionally, expression of rgp120 in the MGAT1–CHO cell expression system reduces heterogeneity in net charge as compared to CHO-expressed rgp120.
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PMC11588008
During this period, take a new EP tube, add 500 μL of isopropanol, and precool on ice.
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PMC9429973
Fusions were validated by RT-PCR and/or FISH.
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PMC6222726
On the other hand, the results on the antimutagenic potential of this compound showed a strong inhibitory effect against some direct and indirect-acting mutagens.
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PMC9351137
B The graph summarized the results.
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PMC9429973
The incidence of adverse events (AEs) was reported cumulatively from baseline.
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PMC10926885
Real‐time quantitative PCR was performed via an Applied Biosystems SYBR Green Mix Kit and an ABI 7900 Real‐Time PCR System (Applied Biosystems Life Technologies, Foster City, CA, USA).
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PMC11306331
However, few tools are available to perform the converse function – dissolving a condensate of interest on demand.
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PMC11757230
Notably, in two mice treated with high doses of cADSCs (2/6, 33 %), no bioluminescence signal was detected in the lungs (Fig. 6b and c).
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PMC11448304
Methods for establishing radioresistant cell lines have been introduced in several articles [3–5], in brief, Cells were exposed to fractionated X-ray treatments, after which the surviving cells were cultured and selected.
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PMC11474209
In California, domestic animal poisonings have been linked to blooms of Microcystis sp .
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PMC11699042
All cell lines were routinely tested for mycoplasma contamination by nested PCR, and cell line purity and authenticity were confirmed by STR profiling.
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PMC11574271
These cell lines were inoculated into thymic nude mice and tumor growth was monitored.
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PMC10812665
The area under the peak was quantified using the ChromStar version 7.0 software (SCPA, Weyhe-Leehste, Germany) and by comparison to reference standards, the concentration was determined.
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PMC11092382
The Kaihoujian recipe originates from Miao traditional medicine in China and has a long history.
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PMC11792090
In addition, elevated IL-6 levels are considered as the hallmark of cytokine-release syndrome (CRS) (40), a common side effect of CAR-T therapy, and the reduced IL-6 releasing observed in SAP UCAR-T cells suggested a lower risk of safety issues ( Figure 5E ).
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PMC10944868
Besides the above mentioned result on the A549 cell line, it also showed second best result among all the studied compounds on the BT20 cell line with an IC50 = 9.89 ± 0.25 and in HCT116 cell line with an IC50 = 16.10 ± 1.20 (Figure 2; Table 1, entry 24).
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PMC11703992
G WB of inflammatory factors TNF-α in culture of DDIT4-OE and PMA induced Jurkat cells.
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PMC11477621
Starting from ethyl 7-bromoheptanoate (1d) (1.21 g, 5.10 mmol) and indole (497 mg, 4.25 mmol), the title compound was obtained following the procedure previously described for compound 2a.
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PMC2777936
Gene expression profiles were determined in cells treated with +/- RA for 4 days.
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PMC11591794
KEGG pathway enrichment analysis of target genes was performed with the Shiny 0.80 program.
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