OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11626627	The survival analysis data were obtained from Kaplan-Meier plotter (https://kmplot.com, accessed on 15 July 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "survival", "analysis", "data", "were", "obtained", "from", "Kaplan-Meier", "plotter", "(", "https://kmplot.com", ",", "accessed", "on", "15", "July", "2022", ")", "." ] } ]
PMC11451940	calcd. (%)	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "calcd", ".", "(", "%", ")" ] } ]
PMC8759873	In recent years, ultrasound has attracted much attention.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "years", ",", "ultrasound", "has", "attracted", "much", "attention", "." ] } ]
PMC10938377	X-ray crystallographic analysis was conducted using NCP assembled with recombinant Homo sapiens histones and a 145 bp DNA fragment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "X-ray", "crystallographic", "analysis", "was", "conducted", "using", "NCP", "assembled", "with", "recombinant", "Homo", "sapiens", "histones", "and", "a", "145", "bp", "DNA", "fragment", "." ] } ]
PMC9105697	Calculations showed a correlation coefficient of 0.55 with a p value of 0.0276.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calculations", "showed", "a", "correlation", "coefficient", "of", "0.55", "with", "a", "p", "value", "of", "0.0276", "." ] } ]
PMC9429973	Disease-related complications related to β-thal were experienced by all patients (total 1089 [median 5 (range, 1–21)]; 22.1% were Grade ≥3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Disease-related", "complications", "related", "to", "β-thal", "were", "experienced", "by", "all", "patients", "(", "total", "1089", "[", "median", "5", "(", "range", ",", "1–21", ")", "]", ";", "22.1", "%", "were", "Grade", "≥3", ")", "." ] } ]
PMC11740907	To dissolve the cells, the slides were submerged in a pH-10 lysis solution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "dissolve", "the", "cells", ",", "the", "slides", "were", "submerged", "in", "a", "pH-10", "lysis", "solution", "." ] } ]
PMC11699465	The symbol ∗ indicates p < 0.05; ∗∗ indicates p < 0.01; ∗∗∗indicates p < 0.001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "symbol", "∗", "indicates", "p", "<", "0.05", ";", "∗∗", "indicates", "p", "<", "0.01", ";", "∗∗∗indicates", "p", "<", "0.001", "." ] } ]
PMC11538390	Supporting this conclusion, the rs570516915 variant shows a significant association with CP alone, while rs642961 is strongly associated with CL and modestly associated with CLP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Supporting", "this", "conclusion", ",", "the", "rs570516915", "variant", "shows", "a", "significant", "association", "with", "CP", "alone", ",", "while", "rs642961", "is", "strongly", "associated", "with", "CL", "and", "modestly", "associated", "with", "CLP", "." ] } ]
PMC11612315	Among the exendin 9–39 fragments, exendin 20–29 specifically binds to TRPV1, alleviating pain in both acute and chronic pain models without interfering with GLP-1R function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "exendin", "9–39", "fragments", ",", "exendin", "20–29", "specifically", "binds", "to", "TRPV1", ",", "alleviating", "pain", "in", "both", "acute", "and", "chronic", "pain", "models", "without", "interfering", "with", "GLP-1R", "function", "." ] } ]
PMC11377827	Alternatively, 14-3-3 proteins may assist with the nuclear translocation due to their ability to enable free shuttling between the nucleus and cytoplasm (Brunet et al, 2002), or through ligand binding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alternatively", ",", "14", "-", "3", "-", "3", "proteins", "may", "assist", "with", "the", "nuclear", "translocation", "due", "to", "their", "ability", "to", "enable", "free", "shuttling", "between", "the", "nucleus", "and", "cytoplasm", "(", "Brunet", "et", "al", ",", "2002", ")", ",", "or", "through", "ligand", "binding", "." ] } ]
PMC11756937	When Versene was used, 2 mL of growth medium was added for a wash.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "Versene", "was", "used", ",", "2", "mL", "of", "growth", "medium", "was", "added", "for", "a", "wash", "." ] } ]
PMC11063646	Andrographolide concentration in emulgel was measured by UV spectrophotometer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Andrographolide", "concentration", "in", "emulgel", "was", "measured", "by", "UV", "spectrophotometer", "." ] } ]
PMC9429973	Patients were considered as fit when CIRS(cumulative illness rating skill) was inferior to six.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "were", "considered", "as", "fit", "when", "CIRS(cumulative", "illness", "rating", "skill", ")", "was", "inferior", "to", "six", "." ] } ]
PMC9926039	The interaction between methadone and active site of toll-like receptor 4 and MD-2 visualized by Discovery Studio 2016 In the current study, a significant increase in the level of TLR4 expression was observed in the methadone-treated A549 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "interaction", "between", "methadone", "and", "active", "site", "of", "toll-like", "receptor", "4", "and", "MD-2", "visualized", "by", "Discovery", "Studio", "2016", "In", "the", "current", "study", ",", "a", "significant", "increase", "in", "the", "level", "of", "TLR4", "expression", "was", "observed", "in", "the", "methadone-treated", "A549", "cells", "." ] } ]
PMC10589262	One-way ANOVA with a post-hoc test was performed to compare multiple means (p < 0.05, p < 0.01, **p < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One-way", "ANOVA", "with", "a", "post-hoc", "test", "was", "performed", "to", "compare", "multiple", "means", "(", "", "p", "<", "0.05", ",", "", "", "p", "<", "0.01", ",", "", "", "", "p", "<", "0.001", ")", "." ] } ]
PMC11599565	However, it remains unclear whether the acquisition of neuroepithelial features in OC corresponds to more aggressive tumor types or persistent chemotherapy refraction of dormant OC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "remains", "unclear", "whether", "the", "acquisition", "of", "neuroepithelial", "features", "in", "OC", "corresponds", "to", "more", "aggressive", "tumor", "types", "or", "persistent", "chemotherapy", "refraction", "of", "dormant", "OC", "cells", "." ] } ]
PMC11462673	2 × 10 cells were incubated with cold Nuclear Extract Buffer for 10 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2", "×", "10", "cells", "were", "incubated", "with", "cold", "Nuclear", "Extract", "Buffer", "for", "10", "min", "." ] } ]
PMC9541067	f–h Quantitative description to (e) and (g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "–", "h", "Quantitative", "description", "to", "(", "e", ")", "and", "(", "g", ")", "." ] } ]
PMC7185206	Flow cytometry of extracellular vesicles (EVs) was performed on isolated supernatants from cell culture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "of", "extracellular", "vesicles", "(", "EVs", ")", "was", "performed", "on", "isolated", "supernatants", "from", "cell", "culture", "." ] } ]
PMC11190538	As a result, C-phycocyanin did not influence starting culture development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "C-phycocyanin", "did", "not", "influence", "starting", "culture", "development", "." ] } ]
PMC9429973	Costs were obtained from a Canadian public health payer’s perspective (CAN$1=US$0.78) and inflation-adjusted for 2022.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Costs", "were", "obtained", "from", "a", "Canadian", "public", "health", "payer", "’s", "perspective", "(", "CAN$1=US$0.78", ")", "and", "inflation-adjusted", "for", "2022", "." ] } ]
PMC6034753	The CtBP and BZIP-domains are not involved in interaction with apoptin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CtBP", "and", "BZIP-domains", "are", "not", "involved", "in", "interaction", "with", "apoptin", "." ] } ]
PMC8609870	Additionally, the cell component (CC) changes of DELs were obviously enriched in transcription factor complex, axon part, postsynaptic specialization, histone methyltransferase complex, clathrin-coated pit, MLL1/2 complex, hemoglobin complex, MLL1 complex, haptoglobin-hemoglobin complex and exocyst.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", "cell", "component", "(", "CC", ")", "changes", "of", "DELs", "were", "obviously", "enriched", "in", "transcription", "factor", "complex", ",", "axon", "part", ",", "postsynaptic", "specialization", ",", "histone", "methyltransferase", "complex", ",", "clathrin-coated", "pit", ",", "MLL1/2", "complex", ",", "hemoglobin", "complex", ",", "MLL1", "complex", ",", "haptoglobin-hemoglobin", "complex", "and", "exocyst", "." ] } ]
PMC11611077	Average cell area.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Average", "cell", "area", "." ] } ]
PMC9681981	The PCR results of cpa, etx, and 16S rRNA genes were shown in Fig. 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PCR", "results", "of", "cpa", ",", "etx", ",", "and", "16S", "rRNA", "genes", "were", "shown", "in", "Fig.", "4", "." ] } ]
PMC11453018	Gene expression analyses revealed a significant upregulation of PI3K, mTOR, MCL-1, and ERBB2, and a reduction of BCL-2 and SRC2 (Fig. 5E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "expression", "analyses", "revealed", "a", "significant", "upregulation", "of", "PI3", "K", ",", "mTOR", ",", "MCL-1", ",", "and", "ERBB2", ",", "and", "a", "reduction", "of", "BCL-2", "and", "SRC2", "(", "Fig.", "5E", ")", "." ] } ]
PMC9429973	All grades CRS occurred in 89%, including ≥grade 3 in 2.7%, median time to onset was 3 days (min-max 0-14) and median duration 6 days (min-max 1-17).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "grades", "CRS", "occurred", "in", "89", "%", ",", "including", "≥grade", "3", "in", "2.7", "%", ",", "median", "time", "to", "onset", "was", "3", "days", "(", "min-max", "0", "-", "14", ")", "and", "median", "duration", "6", "days", "(", "min-max", "1", "-", "17", ")", "." ] } ]
PMC11732628	Osteosarcoma cells are characterized by high drug resistance and metastasis, which are clinically considered as the leading cause of recurrence and distant metastasis in patients with osteosarcoma (17).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Osteosarcoma", "cells", "are", "characterized", "by", "high", "drug", "resistance", "and", "metastasis", ",", "which", "are", "clinically", "considered", "as", "the", "leading", "cause", "of", "recurrence", "and", "distant", "metastasis", "in", "patients", "with", "osteosarcoma", "(", "17", ")", "." ] } ]
PMC9031474	Especially, the cinnamoyl derivatives 18 and 19 exhibited increased cytotoxic activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Especially", ",", "the", "cinnamoyl", "derivatives", "18", "and", "19", "exhibited", "increased", "cytotoxic", "activities", "." ] } ]
PMC11612626	NuPAGE MES SDS running buffer (Invitrogen, #NP0002) was used for resolving small- to medium-sized proteins and NuPAGE MOPS SDS running buffer (Invitrogen, #NP0001) used to resolve medium-large–sized proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NuPAGE", "MES", "SDS", "running", "buffer", "(", "Invitrogen", ",", "#", "NP0002", ")", "was", "used", "for", "resolving", "small-", "to", "medium-sized", "proteins", "and", "NuPAGE", "MOPS", "SDS", "running", "buffer", "(", "Invitrogen", ",", "#", "NP0001", ")", "used", "to", "resolve", "medium-large", "–", "sized", "proteins", "." ] } ]
PMC5941560	The damaged genes affecting T-cell receptor signaling are PTEN, INPP5D, CTLA4, and SYK.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "damaged", "genes", "affecting", "T-cell", "receptor", "signaling", "are", "PTEN", ",", "INPP5D", ",", "CTLA4", ",", "and", "SYK", "." ] } ]
PMC9014716	Total RNA was collected for quantitative real-time polymerase chain reaction (qRT-PCR) analysis and the protein content was collected for western blot analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "RNA", "was", "collected", "for", "quantitative", "real-time", "polymerase", "chain", "reaction", "(", "qRT-PCR", ")", "analysis", "and", "the", "protein", "content", "was", "collected", "for", "western", "blot", "analysis", "." ] } ]
PMC2944824	Thapsigargin and tunicamycin induce apoptosis by stressing the ER whereas staurosporine induces apoptosis by acting directly on the mitochondria .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thapsigargin", "and", "tunicamycin", "induce", "apoptosis", "by", "stressing", "the", "ER", "whereas", "staurosporine", "induces", "apoptosis", "by", "acting", "directly", "on", "the", "mitochondria", "." ] } ]
PMC11171319	Recently our group reported that human astrocytes chronically infected and transformed by oncogenic HR-HCMV strains (HCMV-DB strain and HCMV strains isolated from glioblastoma patients) generated spheroids that resulted in the appearance of glioblastoma-like tumors in xenografted mice .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", "our", "group", "reported", "that", "human", "astrocytes", "chronically", "infected", "and", "transformed", "by", "oncogenic", "HR-HCMV", "strains", "(", "HCMV-DB", "strain", "and", "HCMV", "strains", "isolated", "from", "glioblastoma", "patients", ")", "generated", "spheroids", "that", "resulted", "in", "the", "appearance", "of", "glioblastoma-like", "tumors", "in", "xenografted", "mice", "." ] } ]
PMC9429973	BM fibrosis improvement by ≥1 grade was achieved in 31% (16/52) and 25% (9/36) pts in Arm 3 and 2, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BM", "fibrosis", "improvement", "by", "≥1", "grade", "was", "achieved", "in", "31", "%", "(", "16/52", ")", "and", "25", "%", "(", "9/36", ")", "pts", "in", "Arm", "3", "and", "2", ",", "respectively", "." ] } ]
PMC11634027	Quantifications for western blots are presented as mean±s.e.m.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantifications", "for", "western", "blots", "are", "presented", "as", "mean±s.e.m", "." ] } ]
PMC11705630	Further studies to develop a specific inhibitor of GLDC are also necessary.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "studies", "to", "develop", "a", "specific", "inhibitor", "of", "GLDC", "are", "also", "necessary", "." ] } ]
PMC11594641	The RAB27A/B double knockout moderately decreased the migratory capacity of A375 cells without disturbing their invasiveness.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RAB27A/B", "double", "knockout", "moderately", "decreased", "the", "migratory", "capacity", "of", "A375", "cells", "without", "disturbing", "their", "invasiveness", "." ] } ]
PMC10582049	The results of our research show that ADH1B CAFs correlate with LUAD behavior and can be used for the prediction of tumor aggressiveness at an early stage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "of", "our", "research", "show", "that", "ADH1B", "CAFs", "correlate", "with", "LUAD", "behavior", "and", "can", "be", "used", "for", "the", "prediction", "of", "tumor", "aggressiveness", "at", "an", "early", "stage", "." ] } ]
PMC11794568	Cells were then fixed, permeabilized and stained according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "then", "fixed", ",", "permeabilized", "and", "stained", "according", "to", "the", "manufacturer", "’s", "instructions", "." ] } ]
PMC11320834	Topotecan-related DSBs induce multiple types of DNA damage, and olaparib diminishes the PARP enzyme's ability to repair it.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Topotecan-related", "DSBs", "induce", "multiple", "types", "of", "DNA", "damage", ",", "and", "olaparib", "diminishes", "the", "PARP", "enzyme", "'s", "ability", "to", "repair", "it", "." ] } ]
PMC11544771	Whether the discrepancy is related to the different concentrations of PRE used needs to be further investigated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whether", "the", "discrepancy", "is", "related", "to", "the", "different", "concentrations", "of", "PRE", "used", "needs", "to", "be", "further", "investigated", "." ] } ]
PMC10024132	This research was funded by Manysmart Therapeutics Inc. C.M.L. is a founder of Manysmart Therapeutics Inc. C.H.L. is an employee and a cofounder of Manysmart Therapeutics Inc. S.J.W. and C.T.L. declare no competing interests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "research", "was", "funded", "by", "Manysmart", "Therapeutics", "Inc.", "C.M.L.", "is", "a", "founder", "of", "Manysmart", "Therapeutics", "Inc.", "C.H.L.", "is", "an", "employee", "and", "a", "cofounder", "of", "Manysmart", "Therapeutics", "Inc.", "S.J.W.", "and", "C.T.L.", "declare", "no", "competing", "interests", "." ] } ]
PMC11285179	CCL28 significantly increased the migration distance of pericytes compared to the control group (Fig. 2E, right panel).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CCL28", "significantly", "increased", "the", "migration", "distance", "of", "pericytes", "compared", "to", "the", "control", "group", "(", "Fig.", "2E", ",", "right", "panel", ")", "." ] } ]
PMC11352877	Four subtypes of angiopoietins (ANG1, ANG2, ANG3, and ANG4) have previously been described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "subtypes", "of", "angiopoietins", "(", "ANG1", ",", "ANG2", ",", "ANG3", ",", "and", "ANG4", ")", "have", "previously", "been", "described", "." ] } ]
PMC3888431	Two pipelines to extend and improve the CHO cell line transcripts were established.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "pipelines", "to", "extend", "and", "improve", "the", "CHO", "cell", "line", "transcripts", "were", "established", "." ] } ]
PMC9429973	To ameliorate patients’ outcome there is an urgent need to discover new treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "ameliorate", "patients", "’", "outcome", "there", "is", "an", "urgent", "need", "to", "discover", "new", "treatments", "." ] } ]
PMC4485648	There are only few studies on SFN effect in hypoxic cancer cells (11–13).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "are", "only", "few", "studies", "on", "SFN", "effect", "in", "hypoxic", "cancer", "cells", "(", "11–13", ")", "." ] } ]
PMC11775197	Hence, there is positive feedback between PPARβ/δ, COX-2, and PGE2, which is a key factor in promoting tumorigenesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "there", "is", "positive", "feedback", "between", "PPARβ/δ", ",", "COX-2", ",", "and", "PGE2", ",", "which", "is", "a", "key", "factor", "in", "promoting", "tumorigenesis", "." ] } ]
PMC11185260	N = 4–6/group.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "N", "=", "4–6/group", "." ] } ]
PMC11496491	The results of this study showed that all samples were qualified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "of", "this", "study", "showed", "that", "all", "samples", "were", "qualified", "." ] } ]
PMC9878562	To get a better insight we sorted ACKR3 and ACKR3 VAL cells and analyzed their migratory properties in chemotaxis assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "get", "a", "better", "insight", "we", "sorted", "ACKR3", "and", "ACKR3", "VAL", "cells", "and", "analyzed", "their", "migratory", "properties", "in", "chemotaxis", "assays", "." ] } ]
PMC7987994	L929 cell line derived from murine fibroblasts (ATCC CCL-1™) and U-2 OS cell line derived from human osteosarcoma (ATCC HTB-96™) were maintained in MEM (Minimal Essential Medium, Sigma, M0446) and DMEM (Dulbecco’s Modified Eagle’s Medium, Sigma, D0819), respectively with 10% FBS at standard conditions of 37 °C, 5% CO2 and 100% relative humidity.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "L929", "cell", "line", "derived", "from", "murine", "fibroblasts", "(", "ATCC", "CCL-1", "™", ")", "and", "U-2", "OS", "cell", "line", "derived", "from", "human", "osteosarcoma", "(", "ATCC", "HTB-96", "™", ")", "were", "maintained", "in", "MEM", "(", "Minimal", "Essential", "Medium", ",", "Sigma", ",", "M0446", ")", "and", "DMEM", "(", "Dulbecco", "’s", "Modified", "Eagle", "’s", "Medium", ",", "Sigma", ",", "D0819", ")", ",", "respectively", "with", "10", "%", "FBS", "at", "standard", "conditions", "of", "37", "°", "C", ",", "5", "%", "CO2", "and", "100", "%", "relative", "humidity", "." ] } ]
PMC9275501	In vivo antitumor experiments showed that HA-GEM-BCL NLCs had the strongest antitumor effect on pancreatic cancer animals compared with other liposomes, and had less systemic toxicity to tumor treatment in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vivo", "antitumor", "experiments", "showed", "that", "HA-GEM-BCL", "NLCs", "had", "the", "strongest", "antitumor", "effect", "on", "pancreatic", "cancer", "animals", "compared", "with", "other", "liposomes", ",", "and", "had", "less", "systemic", "toxicity", "to", "tumor", "treatment", "in", "vivo", "." ] } ]
PMC11543853	MgCl2 was added to a final concentration of 5 mM, and the sample was subjected to DNAse (10 μg/mL final concentration) and RNAse (10 μg/mL final concentration) treatment for 30 min at ambient temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MgCl2", "was", "added", "to", "a", "final", "concentration", "of", "5", "mM", ",", "and", "the", "sample", "was", "subjected", "to", "DNAse", "(", "10", "μg/mL", "final", "concentration", ")", "and", "RNAse", "(", "10", "μg/mL", "final", "concentration", ")", "treatment", "for", "30", "min", "at", "ambient", "temperature", "." ] } ]
PMC11477621	HRMS (ESI), m/z: calcd for C14H21N2O3: 265.1558 [M − H]; found: 265.1557.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HRMS", "(", "ESI", ")", ",", "m/z", ":", "calcd", "for", "C14H21N2O3", ":", "265.1558", "[", "M", "−", "H", "]", ";", "found", ":", "265.1557", "." ] } ]
PMC9429973	Furthermore, RGFP966 exhibited a significant in-vivo antileukemic effect as measured by the burden of disease in the bone marrow of NSG mice transplanted with SKNO1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Furthermore", ",", "RGFP966", "exhibited", "a", "significant", "in-vivo", "antileukemic", "effect", "as", "measured", "by", "the", "burden", "of", "disease", "in", "the", "bone", "marrow", "of", "NSG", "mice", "transplanted", "with", "SKNO1", "cells", "." ] } ]
PMC11705862	Our immunofluorescent staining revealed some colocalization between IRIS-1 and 2 and the astrocyte marker GFAP, evident as white puncta (Fig. 1E, F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "immunofluorescent", "staining", "revealed", "some", "colocalization", "between", "IRIS-1", "and", "2", "and", "the", "astrocyte", "marker", "GFAP", ",", "evident", "as", "white", "puncta", "(", "Fig.", "1E", ",", "F", ")", "." ] } ]
PMC2118063	Genechips were scanned on a high-resolution Affymetrix scanner using GCOS software (version 1.2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genechips", "were", "scanned", "on", "a", "high-resolution", "Affymetrix", "scanner", "using", "GCOS", "software", "(", "version", "1.2", ")", "." ] } ]
PMC9429973	3D imaging of cleared organoids was performed to analyze invasion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3D", "imaging", "of", "cleared", "organoids", "was", "performed", "to", "analyze", "invasion", "." ] } ]
PMC9429973	CAN106 exposure (Cmax and AUC) was dose-proportional, linear, and had low inter-subject variability (<20% CV).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CAN106", "exposure", "(", "Cmax", "and", "AUC", ")", "was", "dose-proportional", ",", "linear", ",", "and", "had", "low", "inter-subject", "variability", "(", "<", "20", "%", "CV", ")", "." ] } ]
PMC10243817	Concomitantly, we discovered that MEX3B modulated TGF-β2 signaling activation in nasal epithelial cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Concomitantly", ",", "we", "discovered", "that", "MEX3B", "modulated", "TGF-β2", "signaling", "activation", "in", "nasal", "epithelial", "cells", "." ] } ]
PMC11476004	In healthy people, the level of DNA damage in the study cited was low—up to 6 (%T DNA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "healthy", "people", ",", "the", "level", "of", "DNA", "damage", "in", "the", "study", "cited", "was", "low", "—", "up", "to", "6", "(", "%", "T", "DNA", ")", "." ] } ]
PMC10142392	The second stage of degradation was followed by a decrease in crystallinity, as the PCL chains in the copolymers were degraded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "second", "stage", "of", "degradation", "was", "followed", "by", "a", "decrease", "in", "crystallinity", ",", "as", "the", "PCL", "chains", "in", "the", "copolymers", "were", "degraded", "." ] } ]
PMC11548041	These findings show that MNVs functionalized with the EpCAM-binding aptamer PLD01 can be used to generate targeted therapeutic cargo delivery vehicles that retain the ability to deliver functional siRNA to EpCAM-expressing cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "show", "that", "MNVs", "functionalized", "with", "the", "EpCAM-binding", "aptamer", "PLD01", "can", "be", "used", "to", "generate", "targeted", "therapeutic", "cargo", "delivery", "vehicles", "that", "retain", "the", "ability", "to", "deliver", "functional", "siRNA", "to", "EpCAM-expressing", "cells", "." ] } ]
PMC11345828	We selected four compounds (25, 26, 27, and 29) to evaluate in dog IV PK studies, that covered a range of mouse PK dispositions and ether structural variety (Table 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "selected", "four", "compounds", "(", "25", ",", "26", ",", "27", ",", "and", "29", ")", "to", "evaluate", "in", "dog", "IV", "PK", "studies", ",", "that", "covered", "a", "range", "of", "mouse", "PK", "dispositions", "and", "ether", "structural", "variety", "(", "Table", "3", ")", "." ] } ]
PMC9592219	High TOP2A expression is a favorable prognostic factor in colorectal cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", "TOP2A", "expression", "is", "a", "favorable", "prognostic", "factor", "in", "colorectal", "cancer", "." ] } ]
PMC8701144	Chemiluminescent detection was performed with the ECL Prime Western blotting Detection Reagent (Amersham–GE Healthcare, Chicago, IL, USA) and the ChemiDoc Touch Imaging System (Bio-Rad, Hercules, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemiluminescent", "detection", "was", "performed", "with", "the", "ECL", "Prime", "Western", "blotting", "Detection", "Reagent", "(", "Amersham", "–", "GE", "Healthcare", ",", "Chicago", ",", "IL", ",", "USA", ")", "and", "the", "ChemiDoc", "Touch", "Imaging", "System", "(", "Bio-Rad", ",", "Hercules", ",", "CA", ",", "USA", ")", "." ] } ]
PMC8345486	After reaction completion (usually 24 h), the solvent was evaporated under vacuum.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "reaction", "completion", "(", "usually", "24", "h", ")", ",", "the", "solvent", "was", "evaporated", "under", "vacuum", "." ] } ]
PMC11297139	Source data are provided as a Source Data file.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", "data", "are", "provided", "as", "a", "Source", "Data", "file", "." ] } ]
PMC9429973	Importantly, patients with a TKI treatment duration <6 years and a low D-PCR result were found to have a clinically acceptable MolR rate (48%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "patients", "with", "a", "TKI", "treatment", "duration", "<", "6", "years", "and", "a", "low", "D-PCR", "result", "were", "found", "to", "have", "a", "clinically", "acceptable", "MolR", "rate", "(", "48", "%", ")", "." ] } ]
PMC2614416	Digestion was carried out by adding 6 μL of 0.40 μg/μL = 2.4 μg of Promega Sequencing Grade trypsin and incubating in Eppendorf Thermomixer R for 20 hr at 37.4°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Digestion", "was", "carried", "out", "by", "adding", "6", "μL", "of", "0.40", "μg/μL", "=", "2.4", "μg", "of", "Promega", "Sequencing", "Grade", "trypsin", "and", "incubating", "in", "Eppendorf", "Thermomixer", "R", "for", "20", "hr", "at", "37.4", "°", "C", "." ] } ]
PMC9429973	20% of patients were diagnosed with lymphoma within 1 year of AIDS diagnosis and antiviral therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "20", "%", "of", "patients", "were", "diagnosed", "with", "lymphoma", "within", "1", "year", "of", "AIDS", "diagnosis", "and", "antiviral", "therapy", "." ] } ]
PMC10955424	Most chemicals were obtained from Sigma Aldrich Israel Ltd. (Rehovot, Israel), otherwise the vendor is specified.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "chemicals", "were", "obtained", "from", "Sigma", "Aldrich", "Israel", "Ltd.", "(", "Rehovot", ",", "Israel", ")", ",", "otherwise", "the", "vendor", "is", "specified", "." ] } ]
PMC9822769	In the present paper, the cytotoxic activity in a panel of seven human tumor cell lines, including a cisplatin-resistant subtype, of the three simple cisplatin-based Pt(IV) models 1–3 (Figure 1) is discussed with respect to its lipophilicity, membrane affinity, reduction potentials, and reduction kinetics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "present", "paper", ",", "the", "cytotoxic", "activity", "in", "a", "panel", "of", "seven", "human", "tumor", "cell", "lines", ",", "including", "a", "cisplatin-resistant", "subtype", ",", "of", "the", "three", "simple", "cisplatin-based", "Pt(IV", ")", "models", "1–3", "(", "Figure", "1", ")", "is", "discussed", "with", "respect", "to", "its", "lipophilicity", ",", "membrane", "affinity", ",", "reduction", "potentials", ",", "and", "reduction", "kinetics", "." ] } ]
PMC11470381	B. Background signal correction involves selecting an ROI in the background region, measuring its average intensity, and subtracting the signal from the original image.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B.", "Background", "signal", "correction", "involves", "selecting", "an", "ROI", "in", "the", "background", "region", ",", "measuring", "its", "average", "intensity", ",", "and", "subtracting", "the", "signal", "from", "the", "original", "image", "." ] } ]
PMC11489175	Thus, ssDNA gap accumulation may be exploited as a biomarker of response to USP1 inhibitors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "ssDNA", "gap", "accumulation", "may", "be", "exploited", "as", "a", "biomarker", "of", "response", "to", "USP1", "inhibitors", "." ] } ]
PMC11615828	Prior to bleaching, an initial image was captured to establish a baseline for fluorescence intensity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Prior", "to", "bleaching", ",", "an", "initial", "image", "was", "captured", "to", "establish", "a", "baseline", "for", "fluorescence", "intensity", "." ] } ]
PMC6182045	Additionally, expression of rgp120 in the MGAT1–CHO cell expression system reduces heterogeneity in net charge as compared to CHO-expressed rgp120.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Additionally", ",", "expression", "of", "rgp120", "in", "the", "MGAT1–CHO", "cell", "expression", "system", "reduces", "heterogeneity", "in", "net", "charge", "as", "compared", "to", "CHO-expressed", "rgp120", "." ] } ]
PMC11588008	During this period, take a new EP tube, add 500 μL of isopropanol, and precool on ice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "this", "period", ",", "take", "a", "new", "EP", "tube", ",", "add", "500", "μL", "of", "isopropanol", ",", "and", "precool", "on", "ice", "." ] } ]
PMC9429973	Fusions were validated by RT-PCR and/or FISH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fusions", "were", "validated", "by", "RT-PCR", "and/or", "FISH", "." ] } ]
PMC6222726	On the other hand, the results on the antimutagenic potential of this compound showed a strong inhibitory effect against some direct and indirect-acting mutagens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "the", "results", "on", "the", "antimutagenic", "potential", "of", "this", "compound", "showed", "a", "strong", "inhibitory", "effect", "against", "some", "direct", "and", "indirect-acting", "mutagens", "." ] } ]
PMC9351137	B The graph summarized the results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "The", "graph", "summarized", "the", "results", "." ] } ]
PMC9429973	The incidence of adverse events (AEs) was reported cumulatively from baseline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "incidence", "of", "adverse", "events", "(", "AEs", ")", "was", "reported", "cumulatively", "from", "baseline", "." ] } ]
PMC10926885	Real‐time quantitative PCR was performed via an Applied Biosystems SYBR Green Mix Kit and an ABI 7900 Real‐Time PCR System (Applied Biosystems Life Technologies, Foster City, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Real‐time", "quantitative", "PCR", "was", "performed", "via", "an", "Applied", "Biosystems", "SYBR", "Green", "Mix", "Kit", "and", "an", "ABI", "7900", "Real‐Time", "PCR", "System", "(", "Applied", "Biosystems", "Life", "Technologies", ",", "Foster", "City", ",", "CA", ",", "USA", ")", "." ] } ]
PMC11306331	However, few tools are available to perform the converse function – dissolving a condensate of interest on demand.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "few", "tools", "are", "available", "to", "perform", "the", "converse", "function", "–", "dissolving", "a", "condensate", "of", "interest", "on", "demand", "." ] } ]
PMC11757230	Notably, in two mice treated with high doses of cADSCs (2/6, 33 %), no bioluminescence signal was detected in the lungs (Fig. 6b and c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "in", "two", "mice", "treated", "with", "high", "doses", "of", "cADSCs", "(", "2/6", ",", "33", "%", ")", ",", "no", "bioluminescence", "signal", "was", "detected", "in", "the", "lungs", "(", "Fig.", "6b", "and", "c", ")", "." ] } ]
PMC11448304	Methods for establishing radioresistant cell lines have been introduced in several articles [3–5], in brief, Cells were exposed to fractionated X-ray treatments, after which the surviving cells were cultured and selected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", "for", "establishing", "radioresistant", "cell", "lines", "have", "been", "introduced", "in", "several", "articles", "[", "3–5", "]", ",", "in", "brief", ",", "Cells", "were", "exposed", "to", "fractionated", "X-ray", "treatments", ",", "after", "which", "the", "surviving", "cells", "were", "cultured", "and", "selected", "." ] } ]
PMC11474209	In California, domestic animal poisonings have been linked to blooms of Microcystis sp .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "California", ",", "domestic", "animal", "poisonings", "have", "been", "linked", "to", "blooms", "of", "Microcystis", "sp", "." ] } ]
PMC11699042	All cell lines were routinely tested for mycoplasma contamination by nested PCR, and cell line purity and authenticity were confirmed by STR profiling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "cell", "lines", "were", "routinely", "tested", "for", "mycoplasma", "contamination", "by", "nested", "PCR", ",", "and", "cell", "line", "purity", "and", "authenticity", "were", "confirmed", "by", "STR", "profiling", "." ] } ]
PMC11574271	These cell lines were inoculated into thymic nude mice and tumor growth was monitored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "cell", "lines", "were", "inoculated", "into", "thymic", "nude", "mice", "and", "tumor", "growth", "was", "monitored", "." ] } ]
PMC10812665	The area under the peak was quantified using the ChromStar version 7.0 software (SCPA, Weyhe-Leehste, Germany) and by comparison to reference standards, the concentration was determined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "area", "under", "the", "peak", "was", "quantified", "using", "the", "ChromStar", "version", "7.0", "software", "(", "SCPA", ",", "Weyhe-Leehste", ",", "Germany", ")", "and", "by", "comparison", "to", "reference", "standards", ",", "the", "concentration", "was", "determined", "." ] } ]
PMC11092382	The Kaihoujian recipe originates from Miao traditional medicine in China and has a long history.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Kaihoujian", "recipe", "originates", "from", "Miao", "traditional", "medicine", "in", "China", "and", "has", "a", "long", "history", "." ] } ]
PMC11792090	In addition, elevated IL-6 levels are considered as the hallmark of cytokine-release syndrome (CRS) (40), a common side effect of CAR-T therapy, and the reduced IL-6 releasing observed in SAP UCAR-T cells suggested a lower risk of safety issues ( Figure 5E ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "elevated", "IL-6", "levels", "are", "considered", "as", "the", "hallmark", "of", "cytokine-release", "syndrome", "(", "CRS", ")", "(", "40", ")", ",", "a", "common", "side", "effect", "of", "CAR-T", "therapy", ",", "and", "the", "reduced", "IL-6", "releasing", "observed", "in", "SAP", "UCAR-T", "cells", "suggested", "a", "lower", "risk", "of", "safety", "issues", "(", "Figure", "5E", ")", "." ] } ]
PMC10944868	Besides the above mentioned result on the A549 cell line, it also showed second best result among all the studied compounds on the BT20 cell line with an IC50 = 9.89 ± 0.25 and in HCT116 cell line with an IC50 = 16.10 ± 1.20 (Figure 2; Table 1, entry 24).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", "the", "above", "mentioned", "result", "on", "the", "A549", "cell", "line", ",", "it", "also", "showed", "second", "best", "result", "among", "all", "the", "studied", "compounds", "on", "the", "BT20", "cell", "line", "with", "an", "IC50", "=", "9.89", "±", "0.25", "and", "in", "HCT116", "cell", "line", "with", "an", "IC50", "=", "16.10", "±", "1.20", "(", "Figure", "2", ";", "Table", "1", ",", "entry", "24", ")", "." ] } ]
PMC11703992	G WB of inflammatory factors TNF-α in culture of DDIT4-OE and PMA induced Jurkat cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "G", "WB", "of", "inflammatory", "factors", "TNF-α", "in", "culture", "of", "DDIT4-OE", "and", "PMA", "induced", "Jurkat", "cells", "." ] } ]
PMC11477621	Starting from ethyl 7-bromoheptanoate (1d) (1.21 g, 5.10 mmol) and indole (497 mg, 4.25 mmol), the title compound was obtained following the procedure previously described for compound 2a.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Starting", "from", "ethyl", "7-bromoheptanoate", "(", "1d", ")", "(", "1.21", "g", ",", "5.10", "mmol", ")", "and", "indole", "(", "497", "mg", ",", "4.25", "mmol", ")", ",", "the", "title", "compound", "was", "obtained", "following", "the", "procedure", "previously", "described", "for", "compound", "2a", "." ] } ]
PMC2777936	Gene expression profiles were determined in cells treated with +/- RA for 4 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "expression", "profiles", "were", "determined", "in", "cells", "treated", "with", "+", "/-", "RA", "for", "4", "days", "." ] } ]
PMC11591794	KEGG pathway enrichment analysis of target genes was performed with the Shiny 0.80 program.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KEGG", "pathway", "enrichment", "analysis", "of", "target", "genes", "was", "performed", "with", "the", "Shiny", "0.80", "program", "." ] } ]

PMC11626627

The survival analysis data were obtained from Kaplan-Meier plotter (https://kmplot.com, accessed on 15 July 2022).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "survival", "analysis", "data", "were", "obtained", "from", "Kaplan-Meier", "plotter", "(", "https://kmplot.com", ",", "accessed", "on", "15", "July", "2022", ")", "." ] } ]

PMC11451940

calcd. (%)

[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "calcd", ".", "(", "%", ")" ] } ]

PMC8759873

In recent years, ultrasound has attracted much attention.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "years", ",", "ultrasound", "has", "attracted", "much", "attention", "." ] } ]

PMC10938377

X-ray crystallographic analysis was conducted using NCP assembled with recombinant Homo sapiens histones and a 145 bp DNA fragment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "X-ray", "crystallographic", "analysis", "was", "conducted", "using", "NCP", "assembled", "with", "recombinant", "Homo", "sapiens", "histones", "and", "a", "145", "bp", "DNA", "fragment", "." ] } ]

PMC9105697

Calculations showed a correlation coefficient of 0.55 with a p value of 0.0276.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calculations", "showed", "a", "correlation", "coefficient", "of", "0.55", "with", "a", "p", "value", "of", "0.0276", "." ] } ]

PMC9429973

Disease-related complications related to β-thal were experienced by all patients (total 1089 [median 5 (range, 1–21)]; 22.1% were Grade ≥3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Disease-related", "complications", "related", "to", "β-thal", "were", "experienced", "by", "all", "patients", "(", "total", "1089", "[", "median", "5", "(", "range", ",", "1–21", ")", "]", ";", "22.1", "%", "were", "Grade", "≥3", ")", "." ] } ]

PMC11740907

To dissolve the cells, the slides were submerged in a pH-10 lysis solution.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "dissolve", "the", "cells", ",", "the", "slides", "were", "submerged", "in", "a", "pH-10", "lysis", "solution", "." ] } ]

PMC11699465

The symbol ∗ indicates p < 0.05; ∗∗ indicates p < 0.01; ∗∗∗indicates p < 0.001.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "symbol", "∗", "indicates", "p", "<", "0.05", ";", "∗∗", "indicates", "p", "<", "0.01", ";", "∗∗∗indicates", "p", "<", "0.001", "." ] } ]

PMC11538390

Supporting this conclusion, the rs570516915 variant shows a significant association with CP alone, while rs642961 is strongly associated with CL and modestly associated with CLP.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Supporting", "this", "conclusion", ",", "the", "rs570516915", "variant", "shows", "a", "significant", "association", "with", "CP", "alone", ",", "while", "rs642961", "is", "strongly", "associated", "with", "CL", "and", "modestly", "associated", "with", "CLP", "." ] } ]

PMC11612315

Among the exendin 9–39 fragments, exendin 20–29 specifically binds to TRPV1, alleviating pain in both acute and chronic pain models without interfering with GLP-1R function.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "exendin", "9–39", "fragments", ",", "exendin", "20–29", "specifically", "binds", "to", "TRPV1", ",", "alleviating", "pain", "in", "both", "acute", "and", "chronic", "pain", "models", "without", "interfering", "with", "GLP-1R", "function", "." ] } ]

PMC11377827

Alternatively, 14-3-3 proteins may assist with the nuclear translocation due to their ability to enable free shuttling between the nucleus and cytoplasm (Brunet et al, 2002), or through ligand binding.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alternatively", ",", "14", "-", "3", "-", "3", "proteins", "may", "assist", "with", "the", "nuclear", "translocation", "due", "to", "their", "ability", "to", "enable", "free", "shuttling", "between", "the", "nucleus", "and", "cytoplasm", "(", "Brunet", "et", "al", ",", "2002", ")", ",", "or", "through", "ligand", "binding", "." ] } ]

PMC11756937

When Versene was used, 2 mL of growth medium was added for a wash.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "Versene", "was", "used", ",", "2", "mL", "of", "growth", "medium", "was", "added", "for", "a", "wash", "." ] } ]

PMC11063646

Andrographolide concentration in emulgel was measured by UV spectrophotometer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Andrographolide", "concentration", "in", "emulgel", "was", "measured", "by", "UV", "spectrophotometer", "." ] } ]

PMC9429973

Patients were considered as fit when CIRS(cumulative illness rating skill) was inferior to six.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "were", "considered", "as", "fit", "when", "CIRS(cumulative", "illness", "rating", "skill", ")", "was", "inferior", "to", "six", "." ] } ]

PMC9926039

The interaction between methadone and active site of toll-like receptor 4 and MD-2 visualized by Discovery Studio 2016 In the current study, a significant increase in the level of TLR4 expression was observed in the methadone-treated A549 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "interaction", "between", "methadone", "and", "active", "site", "of", "toll-like", "receptor", "4", "and", "MD-2", "visualized", "by", "Discovery", "Studio", "2016", "In", "the", "current", "study", ",", "a", "significant", "increase", "in", "the", "level", "of", "TLR4", "expression", "was", "observed", "in", "the", "methadone-treated", "A549", "cells", "." ] } ]

PMC10589262

One-way ANOVA with a post-hoc test was performed to compare multiple means (*p < 0.05, **p < 0.01, ***p < 0.001).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One-way", "ANOVA", "with", "a", "post-hoc", "test", "was", "performed", "to", "compare", "multiple", "means", "(", "*", "p", "<", "0.05", ",", "*", "*", "p", "<", "0.01", ",", "*", "*", "*", "p", "<", "0.001", ")", "." ] } ]

PMC11599565

However, it remains unclear whether the acquisition of neuroepithelial features in OC corresponds to more aggressive tumor types or persistent chemotherapy refraction of dormant OC cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "remains", "unclear", "whether", "the", "acquisition", "of", "neuroepithelial", "features", "in", "OC", "corresponds", "to", "more", "aggressive", "tumor", "types", "or", "persistent", "chemotherapy", "refraction", "of", "dormant", "OC", "cells", "." ] } ]

PMC11462673

2 × 10 cells were incubated with cold Nuclear Extract Buffer for 10 min.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2", "×", "10", "cells", "were", "incubated", "with", "cold", "Nuclear", "Extract", "Buffer", "for", "10", "min", "." ] } ]

PMC9541067

f–h Quantitative description to (e) and (g).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "–", "h", "Quantitative", "description", "to", "(", "e", ")", "and", "(", "g", ")", "." ] } ]

PMC7185206

Flow cytometry of extracellular vesicles (EVs) was performed on isolated supernatants from cell culture.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "of", "extracellular", "vesicles", "(", "EVs", ")", "was", "performed", "on", "isolated", "supernatants", "from", "cell", "culture", "." ] } ]

PMC11190538

As a result, C-phycocyanin did not influence starting culture development.

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PMC9429973

Costs were obtained from a Canadian public health payer’s perspective (CAN$1=US$0.78) and inflation-adjusted for 2022.

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PMC6034753

The CtBP and BZIP-domains are not involved in interaction with apoptin.

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PMC8609870

Additionally, the cell component (CC) changes of DELs were obviously enriched in transcription factor complex, axon part, postsynaptic specialization, histone methyltransferase complex, clathrin-coated pit, MLL1/2 complex, hemoglobin complex, MLL1 complex, haptoglobin-hemoglobin complex and exocyst.

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PMC11611077

Average cell area.

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PMC9681981

The PCR results of cpa, etx, and 16S rRNA genes were shown in Fig. 4.

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PMC11453018

Gene expression analyses revealed a significant upregulation of PI3K, mTOR, MCL-1, and ERBB2, and a reduction of BCL-2 and SRC2 (Fig. 5E).

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PMC9429973

All grades CRS occurred in 89%, including ≥grade 3 in 2.7%, median time to onset was 3 days (min-max 0-14) and median duration 6 days (min-max 1-17).

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PMC11732628

Osteosarcoma cells are characterized by high drug resistance and metastasis, which are clinically considered as the leading cause of recurrence and distant metastasis in patients with osteosarcoma (17).

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PMC9031474

Especially, the cinnamoyl derivatives 18 and 19 exhibited increased cytotoxic activities.

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PMC11612626

NuPAGE MES SDS running buffer (Invitrogen, #NP0002) was used for resolving small- to medium-sized proteins and NuPAGE MOPS SDS running buffer (Invitrogen, #NP0001) used to resolve medium-large–sized proteins.

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PMC5941560

The damaged genes affecting T-cell receptor signaling are PTEN, INPP5D, CTLA4, and SYK.

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PMC9014716

Total RNA was collected for quantitative real-time polymerase chain reaction (qRT-PCR) analysis and the protein content was collected for western blot analysis.

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PMC2944824

Thapsigargin and tunicamycin induce apoptosis by stressing the ER whereas staurosporine induces apoptosis by acting directly on the mitochondria .

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PMC11171319

Recently our group reported that human astrocytes chronically infected and transformed by oncogenic HR-HCMV strains (HCMV-DB strain and HCMV strains isolated from glioblastoma patients) generated spheroids that resulted in the appearance of glioblastoma-like tumors in xenografted mice .

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PMC9429973

BM fibrosis improvement by ≥1 grade was achieved in 31% (16/52) and 25% (9/36) pts in Arm 3 and 2, respectively.

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PMC11634027

Quantifications for western blots are presented as mean±s.e.m.

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PMC11705630

Further studies to develop a specific inhibitor of GLDC are also necessary.

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PMC11594641

The RAB27A/B double knockout moderately decreased the migratory capacity of A375 cells without disturbing their invasiveness.

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PMC10582049

The results of our research show that ADH1B CAFs correlate with LUAD behavior and can be used for the prediction of tumor aggressiveness at an early stage.

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PMC11794568

Cells were then fixed, permeabilized and stained according to the manufacturer’s instructions.

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PMC11320834

Topotecan-related DSBs induce multiple types of DNA damage, and olaparib diminishes the PARP enzyme's ability to repair it.

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PMC11544771

Whether the discrepancy is related to the different concentrations of PRE used needs to be further investigated.

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PMC10024132

This research was funded by Manysmart Therapeutics Inc. C.M.L. is a founder of Manysmart Therapeutics Inc. C.H.L. is an employee and a cofounder of Manysmart Therapeutics Inc. S.J.W. and C.T.L. declare no competing interests.

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PMC11285179

CCL28 significantly increased the migration distance of pericytes compared to the control group (Fig. 2E, right panel).

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PMC11352877

Four subtypes of angiopoietins (ANG1, ANG2, ANG3, and ANG4) have previously been described.

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PMC3888431

Two pipelines to extend and improve the CHO cell line transcripts were established.

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PMC9429973

To ameliorate patients’ outcome there is an urgent need to discover new treatments.

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PMC4485648

There are only few studies on SFN effect in hypoxic cancer cells (11–13).

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PMC11775197

Hence, there is positive feedback between PPARβ/δ, COX-2, and PGE2, which is a key factor in promoting tumorigenesis .

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PMC11185260

N = 4–6/group.

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PMC11496491

The results of this study showed that all samples were qualified.

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PMC9878562

To get a better insight we sorted ACKR3 and ACKR3 VAL cells and analyzed their migratory properties in chemotaxis assays.

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PMC7987994

L929 cell line derived from murine fibroblasts (ATCC CCL-1™) and U-2 OS cell line derived from human osteosarcoma (ATCC HTB-96™) were maintained in MEM (Minimal Essential Medium, Sigma, M0446) and DMEM (Dulbecco’s Modified Eagle’s Medium, Sigma, D0819), respectively with 10% FBS at standard conditions of 37 °C, 5% CO2 and 100% relative humidity.

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PMC9275501

In vivo antitumor experiments showed that HA-GEM-BCL NLCs had the strongest antitumor effect on pancreatic cancer animals compared with other liposomes, and had less systemic toxicity to tumor treatment in vivo.

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PMC11543853

MgCl2 was added to a final concentration of 5 mM, and the sample was subjected to DNAse (10 μg/mL final concentration) and RNAse (10 μg/mL final concentration) treatment for 30 min at ambient temperature.

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PMC11477621

HRMS (ESI), m/z: calcd for C14H21N2O3: 265.1558 [M − H]; found: 265.1557.

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PMC9429973

Furthermore, RGFP966 exhibited a significant in-vivo antileukemic effect as measured by the burden of disease in the bone marrow of NSG mice transplanted with SKNO1 cells.

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PMC11705862

Our immunofluorescent staining revealed some colocalization between IRIS-1 and 2 and the astrocyte marker GFAP, evident as white puncta (Fig. 1E, F).

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PMC2118063

Genechips were scanned on a high-resolution Affymetrix scanner using GCOS software (version 1.2).

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PMC9429973

3D imaging of cleared organoids was performed to analyze invasion.

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PMC9429973

CAN106 exposure (Cmax and AUC) was dose-proportional, linear, and had low inter-subject variability (<20% CV).

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PMC10243817

Concomitantly, we discovered that MEX3B modulated TGF-β2 signaling activation in nasal epithelial cells.

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PMC11476004

In healthy people, the level of DNA damage in the study cited was low—up to 6 (%T DNA).

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PMC10142392

The second stage of degradation was followed by a decrease in crystallinity, as the PCL chains in the copolymers were degraded.

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PMC11548041

These findings show that MNVs functionalized with the EpCAM-binding aptamer PLD01 can be used to generate targeted therapeutic cargo delivery vehicles that retain the ability to deliver functional siRNA to EpCAM-expressing cells.

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PMC11345828

We selected four compounds (25, 26, 27, and 29) to evaluate in dog IV PK studies, that covered a range of mouse PK dispositions and ether structural variety (Table 3).

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PMC9592219

High TOP2A expression is a favorable prognostic factor in colorectal cancer .

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PMC8701144

Chemiluminescent detection was performed with the ECL Prime Western blotting Detection Reagent (Amersham–GE Healthcare, Chicago, IL, USA) and the ChemiDoc Touch Imaging System (Bio-Rad, Hercules, CA, USA).

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PMC8345486

After reaction completion (usually 24 h), the solvent was evaporated under vacuum.

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PMC11297139

Source data are provided as a Source Data file.

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PMC9429973

Importantly, patients with a TKI treatment duration <6 years and a low D-PCR result were found to have a clinically acceptable MolR rate (48%).

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PMC2614416

Digestion was carried out by adding 6 μL of 0.40 μg/μL = 2.4 μg of Promega Sequencing Grade trypsin and incubating in Eppendorf Thermomixer R for 20 hr at 37.4°C.

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PMC9429973

20% of patients were diagnosed with lymphoma within 1 year of AIDS diagnosis and antiviral therapy.

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PMC10955424

Most chemicals were obtained from Sigma Aldrich Israel Ltd. (Rehovot, Israel), otherwise the vendor is specified.

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PMC9822769

In the present paper, the cytotoxic activity in a panel of seven human tumor cell lines, including a cisplatin-resistant subtype, of the three simple cisplatin-based Pt(IV) models 1–3 (Figure 1) is discussed with respect to its lipophilicity, membrane affinity, reduction potentials, and reduction kinetics.

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PMC11470381

B. Background signal correction involves selecting an ROI in the background region, measuring its average intensity, and subtracting the signal from the original image.

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PMC11489175

Thus, ssDNA gap accumulation may be exploited as a biomarker of response to USP1 inhibitors.

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PMC11615828

Prior to bleaching, an initial image was captured to establish a baseline for fluorescence intensity.

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PMC6182045

Additionally, expression of rgp120 in the MGAT1–CHO cell expression system reduces heterogeneity in net charge as compared to CHO-expressed rgp120.

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PMC11588008

During this period, take a new EP tube, add 500 μL of isopropanol, and precool on ice.

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PMC9429973

Fusions were validated by RT-PCR and/or FISH.

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PMC6222726

On the other hand, the results on the antimutagenic potential of this compound showed a strong inhibitory effect against some direct and indirect-acting mutagens.

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PMC9351137

B The graph summarized the results.

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PMC9429973

The incidence of adverse events (AEs) was reported cumulatively from baseline.

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PMC10926885

Real‐time quantitative PCR was performed via an Applied Biosystems SYBR Green Mix Kit and an ABI 7900 Real‐Time PCR System (Applied Biosystems Life Technologies, Foster City, CA, USA).

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PMC11306331

However, few tools are available to perform the converse function – dissolving a condensate of interest on demand.

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PMC11757230

Notably, in two mice treated with high doses of cADSCs (2/6, 33 %), no bioluminescence signal was detected in the lungs (Fig. 6b and c).

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PMC11448304

Methods for establishing radioresistant cell lines have been introduced in several articles [3–5], in brief, Cells were exposed to fractionated X-ray treatments, after which the surviving cells were cultured and selected.

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PMC11474209

In California, domestic animal poisonings have been linked to blooms of Microcystis sp .

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PMC11699042

All cell lines were routinely tested for mycoplasma contamination by nested PCR, and cell line purity and authenticity were confirmed by STR profiling.

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PMC11574271

These cell lines were inoculated into thymic nude mice and tumor growth was monitored.

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PMC10812665

The area under the peak was quantified using the ChromStar version 7.0 software (SCPA, Weyhe-Leehste, Germany) and by comparison to reference standards, the concentration was determined.

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PMC11092382

The Kaihoujian recipe originates from Miao traditional medicine in China and has a long history.

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PMC11792090

In addition, elevated IL-6 levels are considered as the hallmark of cytokine-release syndrome (CRS) (40), a common side effect of CAR-T therapy, and the reduced IL-6 releasing observed in SAP UCAR-T cells suggested a lower risk of safety issues ( Figure 5E ).

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PMC10944868

Besides the above mentioned result on the A549 cell line, it also showed second best result among all the studied compounds on the BT20 cell line with an IC50 = 9.89 ± 0.25 and in HCT116 cell line with an IC50 = 16.10 ± 1.20 (Figure 2; Table 1, entry 24).

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PMC11703992

G WB of inflammatory factors TNF-α in culture of DDIT4-OE and PMA induced Jurkat cells.

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PMC11477621

Starting from ethyl 7-bromoheptanoate (1d) (1.21 g, 5.10 mmol) and indole (497 mg, 4.25 mmol), the title compound was obtained following the procedure previously described for compound 2a.

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PMC2777936

Gene expression profiles were determined in cells treated with +/- RA for 4 days.

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PMC11591794

KEGG pathway enrichment analysis of target genes was performed with the Shiny 0.80 program.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KEGG", "pathway", "enrichment", "analysis", "of", "target", "genes", "was", "performed", "with", "the", "Shiny", "0.80", "program", "." ] } ]