OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC10507284	Generally, tumor immune cell infiltration is recognized as an independent predictor of tumor immune status and survival.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Generally", ",", "tumor", "immune", "cell", "infiltration", "is", "recognized", "as", "an", "independent", "predictor", "of", "tumor", "immune", "status", "and", "survival", "." ] } ]
PMC9727330	NNDAsp stimulates IL-1α and IL-1β expression in colon cancer cells To determine the correlation between NNDAsp treatment and produced inflammatory cytokines from treated cells, IL-1α and IL-1β were measured in a time-course experiment using ELISA assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NNDAsp", "stimulates", "IL-1α", "and", "IL-1β", "expression", "in", "colon", "cancer", "cells", "To", "determine", "the", "correlation", "between", "NNDAsp", "treatment", "and", "produced", "inflammatory", "cytokines", "from", "treated", "cells", ",", "IL-1α", "and", "IL-1β", "were", "measured", "in", "a", "time-course", "experiment", "using", "ELISA", "assay", "." ] } ]
PMC3734024	Intriguingly, despite the vast difference in their killing activity there is no consistent difference in FasL protein levels (on a per cell basis) between B cells stimulated with IL-5 and CD40L and those stimulated with IL-4, IL-5, and CD40L (Figure 8B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intriguingly", ",", "despite", "the", "vast", "difference", "in", "their", "killing", "activity", "there", "is", "no", "consistent", "difference", "in", "FasL", "protein", "levels", "(", "on", "a", "per", "cell", "basis", ")", "between", "B", "cells", "stimulated", "with", "IL-5", "and", "CD40L", "and", "those", "stimulated", "with", "IL-4", ",", "IL-5", ",", "and", "CD40L", "(", "Figure", "8B", ")", "." ] } ]
PMC11462673	The T-ALL cell lines utilized in our experiments include Jurkat, 6 T-CEM, J.gamma1, Molt4, PF-382, and others.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "The", "T-ALL", "cell", "lines", "utilized", "in", "our", "experiments", "include", "Jurkat", ",", "6", "T-CEM", ",", "J.gamma1", ",", "Molt4", ",", "PF-382", ",", "and", "others", "." ] } ]
PMC11098378	We envision that our screening methodology can further identify unique IEPs targeting conserved pathways for a variety of pathogen-encoded proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "envision", "that", "our", "screening", "methodology", "can", "further", "identify", "unique", "IEPs", "targeting", "conserved", "pathways", "for", "a", "variety", "of", "pathogen-encoded", "proteins", "." ] } ]
PMC11747949	Lastly, we show the benefits of the tumor cell‐PBMC coculture model as a tool to better delineate the tumor cell phenotypes compared to mono‐cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lastly", ",", "we", "show", "the", "benefits", "of", "the", "tumor", "cell‐PBMC", "coculture", "model", "as", "a", "tool", "to", "better", "delineate", "the", "tumor", "cell", "phenotypes", "compared", "to", "mono‐cultures", "." ] } ]
PMC10998613	The PIE-FCCS results we reported here reveal a more complicated interaction scheme than a simple monomer-dimer equilibrium for CXCR4 and β2AR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PIE-FCCS", "results", "we", "reported", "here", "reveal", "a", "more", "complicated", "interaction", "scheme", "than", "a", "simple", "monomer-dimer", "equilibrium", "for", "CXCR4", "and", "β2AR", "." ] } ]
PMC11772585	However, further investigation is needed to understand the differential expression of METTL1 in cSCC and the role of m7G modification in the development of this tumor type.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "further", "investigation", "is", "needed", "to", "understand", "the", "differential", "expression", "of", "METTL1", "in", "cSCC", "and", "the", "role", "of", "m7", "G", "modification", "in", "the", "development", "of", "this", "tumor", "type", "." ] } ]
PMC11694625	Based on this, we chose the liver and kidneys for biochemical experiments, where the evaluation indicators for the liver were ALT and AST, and the evaluation indicators for the kidneys were urea and creatinine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "this", ",", "we", "chose", "the", "liver", "and", "kidneys", "for", "biochemical", "experiments", ",", "where", "the", "evaluation", "indicators", "for", "the", "liver", "were", "ALT", "and", "AST", ",", "and", "the", "evaluation", "indicators", "for", "the", "kidneys", "were", "urea", "and", "creatinine", "." ] } ]
PMC11694066	siRNA-mediated knockdown of PARP1 conferred resistance to PARPi in JN1 but not R cells (Supplementary Fig. S4B–S4E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "siRNA-mediated", "knockdown", "of", "PARP1", "conferred", "resistance", "to", "PARPi", "in", "JN1", "but", "not", "R", "cells", "(", "Supplementary", "Fig.", "S4B", "–", "S4E", ")", "." ] } ]
PMC11366496	Kaplan–Meier analysis showed a poorer prognosis for patients with RNF122 overexpression (Figure 1F,G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan", "–", "Meier", "analysis", "showed", "a", "poorer", "prognosis", "for", "patients", "with", "RNF122", "overexpression", "(", "Figure", "1F", ",", "G", ")", "." ] } ]
PMC9429973	1-year survival rates were 61.1% (95% CI: 42.9, 75.0) overall, 66.8% (95% CI: 32.4, 86.6) for HCT, and 57.4% (95% CI: 35.2, 74.5) for SOT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1-year", "survival", "rates", "were", "61.1", "%", "(", "95", "%", "CI", ":", "42.9", ",", "75.0", ")", "overall", ",", "66.8", "%", "(", "95", "%", "CI", ":", "32.4", ",", "86.6", ")", "for", "HCT", ",", "and", "57.4", "%", "(", "95", "%", "CI", ":", "35.2", ",", "74.5", ")", "for", "SOT", "." ] } ]
PMC9429973	Summary/Conclusion: In our study histological subtype and type of treatment, but not antiviral therapies, had prognostic impact on the outcome of SARS COV 2 infection in patients with lymphoproliferative disorders during the current phase of pandemic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "In", "our", "study", "histological", "subtype", "and", "type", "of", "treatment", ",", "but", "not", "antiviral", "therapies", ",", "had", "prognostic", "impact", "on", "the", "outcome", "of", "SARS", "COV", "2", "infection", "in", "patients", "with", "lymphoproliferative", "disorders", "during", "the", "current", "phase", "of", "pandemic", "." ] } ]
PMC11596967	This is achieved by improving the peptide’s solubility in lipid environments and accessibility to fat-soluble ROS and polyunsaturated fatty acids .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "achieved", "by", "improving", "the", "peptide", "’s", "solubility", "in", "lipid", "environments", "and", "accessibility", "to", "fat-soluble", "ROS", "and", "polyunsaturated", "fatty", "acids", "." ] } ]
PMC9966931	At 0.125%, (4) nearly lost its activity completely, but it became clear which hybrids from cinnamic acid exerted higher antifungal effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "0.125", "%", ",", "(", "4", ")", "nearly", "lost", "its", "activity", "completely", ",", "but", "it", "became", "clear", "which", "hybrids", "from", "cinnamic", "acid", "exerted", "higher", "antifungal", "effects", "." ] } ]
PMC9412887	Nanomedicines under 5 nm mainly accumulate in kidney.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nanomedicines", "under", "5", "nm", "mainly", "accumulate", "in", "kidney", "." ] } ]
PMC9341513	From the images, we obtain the 3D volumes of the probes; a similar measure is obtained from the simulations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "the", "images", ",", "we", "obtain", "the", "3D", "volumes", "of", "the", "probes", ";", "a", "similar", "measure", "is", "obtained", "from", "the", "simulations", "." ] } ]
PMC11672617	The release of cytochrome c and other pro-apoptotic proteins into the cytosol is a key event in the initiation of the intrinsic (mitochondrial) pathway of cell death, which is triggered by the induction of various types of apoptosis and related events, namely, mitochondrial depolarization and cardiolipin peroxidation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "release", "of", "cytochrome", "c", "and", "other", "pro-apoptotic", "proteins", "into", "the", "cytosol", "is", "a", "key", "event", "in", "the", "initiation", "of", "the", "intrinsic", "(", "mitochondrial", ")", "pathway", "of", "cell", "death", ",", "which", "is", "triggered", "by", "the", "induction", "of", "various", "types", "of", "apoptosis", "and", "related", "events", ",", "namely", ",", "mitochondrial", "depolarization", "and", "cardiolipin", "peroxidation", "." ] } ]
PMC11615828	a,d) The fluorescence images show the distribution of the indicated vesicles in COS7 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "a", ",", "d", ")", "The", "fluorescence", "images", "show", "the", "distribution", "of", "the", "indicated", "vesicles", "in", "COS7", "cells", "." ] } ]
PMC11295144	It is now evident that together with many other proteins, GABAARs and NL2 undergo complex interactions to facilitate synaptic contact formation but how these interactions are coordinated in time and space to lead to the establishment of fully functional inhibitory synapses remains to be described in detail.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "now", "evident", "that", "together", "with", "many", "other", "proteins", ",", "GABAARs", "and", "NL2", "undergo", "complex", "interactions", "to", "facilitate", "synaptic", "contact", "formation", "but", "how", "these", "interactions", "are", "coordinated", "in", "time", "and", "space", "to", "lead", "to", "the", "establishment", "of", "fully", "functional", "inhibitory", "synapses", "remains", "to", "be", "described", "in", "detail", "." ] } ]
PMC11486946	d Immuno-fluorescent images of EGFR in A431, Ba/F3 expressing EGFR, and HeLa cells acquired at 1 h after the compound treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Immuno-fluorescent", "images", "of", "EGFR", "in", "A431", ",", "Ba/F3", "expressing", "EGFR", ",", "and", "HeLa", "cells", "acquired", "at", "1", "h", "after", "the", "compound", "treatment", "." ] } ]
PMC10547921	In a HER2 expressing mouse xenograft model (SK-OV-3ip), a single intravenous ADC dose (5 mg/kg) can cause tumor growth to stop for 3 weeks, better than Kadcyla (5 mg/kg).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "a", "HER2", "expressing", "mouse", "xenograft", "model", "(", "SK-OV-3ip", ")", ",", "a", "single", "intravenous", "ADC", "dose", "(", "5", "mg/kg", ")", "can", "cause", "tumor", "growth", "to", "stop", "for", "3", "weeks", ",", "better", "than", "Kadcyla", "(", "5", "mg/kg", ")", "." ] } ]
PMC11746948	a Schematic of the workflow for identifying palmitoylated proteins using the click chemistry assay and LC-MS/MS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", "Schematic", "of", "the", "workflow", "for", "identifying", "palmitoylated", "proteins", "using", "the", "click", "chemistry", "assay", "and", "LC-MS/MS", "." ] } ]
PMC10969097	All references were exported to the Rayyan systematic review data management platform (https://www.rayyan.ai) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "references", "were", "exported", "to", "the", "Rayyan", "systematic", "review", "data", "management", "platform", "(", "https://www.rayyan.ai", ")", "." ] } ]
PMC10758402	786-0 cells were treated with 150 μM of DMF at various times before or after infection with HSV.n212 (MOI: 0.01) or untreated.	[ { "tags": [ "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "786", "-", "0", "cells", "were", "treated", "with", "150", "μM", "of", "DMF", "at", "various", "times", "before", "or", "after", "infection", "with", "HSV.n212", "(", "MOI", ":", "0.01", ")", "or", "untreated", "." ] } ]
PMC11787651	For the transition settings, precursor and product ion mass were set as monoisotopic, with filters for precursor charges 2 to 4, product ion charge 1, and ion types y, b, and p. A minimum of m/z 50 and a maximum of m/z 1500 with a method-match tolerance of m/z 0.055 were used for the instrument settings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "transition", "settings", ",", "precursor", "and", "product", "ion", "mass", "were", "set", "as", "monoisotopic", ",", "with", "filters", "for", "precursor", "charges", "2", "to", "4", ",", "product", "ion", "charge", "1", ",", "and", "ion", "types", "y", ",", "b", ",", "and", "p.", "A", "minimum", "of", "m/z", "50", "and", "a", "maximum", "of", "m/z", "1500", "with", "a", "method-match", "tolerance", "of", "m/z", "0.055", "were", "used", "for", "the", "instrument", "settings", "." ] } ]
PMC10253973	The results also suggested that a high number of intercalating aromatic rings increased the binding affinity towards the DNA receptors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "also", "suggested", "that", "a", "high", "number", "of", "intercalating", "aromatic", "rings", "increased", "the", "binding", "affinity", "towards", "the", "DNA", "receptors", "." ] } ]
PMC9429973	C. Almeida, R. Costa e Sousa, C. Afonso, A. Roque, D. Luis, L. Araujo, C. Geraldes Hematology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal Background: Hairy cell leukemia (HCL) is an indolent and uncommon chronic B cell lymphoproliferative disorder.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C.", "Almeida", ",", "R.", "Costa", "e", "Sousa", ",", "C.", "Afonso", ",", "A.", "Roque", ",", "D.", "Luis", ",", "L.", "Araujo", ",", "C.", "Geraldes", "Hematology", "Department", ",", "Centro", "Hospitalar", "e", "Universitário", "de", "Coimbra", ",", "Coimbra", ",", "Portugal", "Background", ":", "Hairy", "cell", "leukemia", "(", "HCL", ")", "is", "an", "indolent", "and", "uncommon", "chronic", "B", "cell", "lymphoproliferative", "disorder", "." ] } ]
PMC9848491	As far as diagnostic efficacy is concerned, their results are comparable to ours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "far", "as", "diagnostic", "efficacy", "is", "concerned", ",", "their", "results", "are", "comparable", "to", "ours", "." ] } ]
PMC2196094	Blotting with a VacuBlot unit (Pharmacia, Uppsala, Sweden) was completed in 3 h and the DNA was cross-linked to the membrane by UV-irradiation (GS Gene Linker; BioRad Laboratories, Hercules, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blotting", "with", "a", "VacuBlot", "unit", "(", "Pharmacia", ",", "Uppsala", ",", "Sweden", ")", "was", "completed", "in", "3", "h", "and", "the", "DNA", "was", "cross-linked", "to", "the", "membrane", "by", "UV-irradiation", "(", "GS", "Gene", "Linker", ";", "BioRad", "Laboratories", ",", "Hercules", ",", "CA", ")", "." ] } ]
PMC8409415	A significantly higher percentage of mitotic cells was observed in the CD70‐ADC‐treated than in the control‐ADC group (6.40% [IQR 4.85%‐7.0%] vs 3.48% [IQR 3.0%‐4.0%], P < .01) (Figure 6G, H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "significantly", "higher", "percentage", "of", "mitotic", "cells", "was", "observed", "in", "the", "CD70‐ADC‐treated", "than", "in", "the", "control‐ADC", "group", "(", "6.40", "%", "[", "IQR", "4.85%‐7.0", "%", "]", "vs", "3.48", "%", "[", "IQR", "3.0%‐4.0", "%", "]", ",", "P", "<", ".01", ")", "(", "Figure", "6", "G", ",", "H", ")", "." ] } ]
PMC9541067	d Quantitative analysis to (c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Quantitative", "analysis", "to", "(", "c", ")", "." ] } ]
PMC11525028	For puromycin assay, cells were treated with puromycin at a final concentration of 1 μM for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "puromycin", "assay", ",", "cells", "were", "treated", "with", "puromycin", "at", "a", "final", "concentration", "of", "1", "μM", "for", "30", "min", "." ] } ]
PMC11711347	The presence of a C=N group is revealed by a peak at 1595 cm .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "presence", "of", "a", "C", "=", "N", "group", "is", "revealed", "by", "a", "peak", "at", "1595", "cm", "." ] } ]
PMC9429973	Figure 1).	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Figure", "1", ")", "." ] } ]
PMC11588008	This result indicated that the ERK–Nrf2–HO-1 pathway mediated the protective effects of HUC-MSCs on PM-injured cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "This", "result", "indicated", "that", "the", "ERK", "–", "Nrf2–HO-1", "pathway", "mediated", "the", "protective", "effects", "of", "HUC-MSCs", "on", "PM-injured", "cells", "." ] } ]
PMC11650848	A further area of exploration could be into the evolutionary timeline of these ZFP57 isoforms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "further", "area", "of", "exploration", "could", "be", "into", "the", "evolutionary", "timeline", "of", "these", "ZFP57", "isoforms", "." ] } ]
PMC11531744	This heatmap consisted of blue blocks along the diagonal with the white background.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "heatmap", "consisted", "of", "blue", "blocks", "along", "the", "diagonal", "with", "the", "white", "background", "." ] } ]
PMC9895440	FindMarkers in Seurat was used to calculate differentially expressed genes for each cluster and for all cells in total between Snx9 KO and intergenic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FindMarkers", "in", "Seurat", "was", "used", "to", "calculate", "differentially", "expressed", "genes", "for", "each", "cluster", "and", "for", "all", "cells", "in", "total", "between", "Snx9", "KO", "and", "intergenic", "." ] } ]
PMC11629461	The miniSOG after absorbing blue light (LED 450 nm) produces O2 at a ФΔ of ≥0.03. ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "miniSOG", "after", "absorbing", "blue", "light", "(", "LED", "450", "nm", ")", "produces", "O2", "at", "a", "ФΔ", "of", "≥0.03", ".", "," ] } ]
PMC9429973	However, between 5-40% of patients fail to obtain an adequate collection of hematopoietic progenitor cells (HPCs), this is known as mobilization failure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "between", "5", "-", "40", "%", "of", "patients", "fail", "to", "obtain", "an", "adequate", "collection", "of", "hematopoietic", "progenitor", "cells", "(", "HPCs", ")", ",", "this", "is", "known", "as", "mobilization", "failure", "." ] } ]
PMC11769522	Accordingly, 100 µL of the cell culture supernatant was used for the analysis of IL-6 concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Accordingly", ",", "100", "µL", "of", "the", "cell", "culture", "supernatant", "was", "used", "for", "the", "analysis", "of", "IL-6", "concentrations", "." ] } ]
PMC11802855	The observations also revealed that the expression levels of MMP2, MMP9, and MMP13 in the bone tissue of mice in the OE group were significantly elevated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "observations", "also", "revealed", "that", "the", "expression", "levels", "of", "MMP2", ",", "MMP9", ",", "and", "MMP13", "in", "the", "bone", "tissue", "of", "mice", "in", "the", "OE", "group", "were", "significantly", "elevated", "." ] } ]
PMC10919056	Finally, 400 μL of binding buffer was added to the culture tube, which was subsequently analyzed after 10 to 15 minutes using flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "400", "μL", "of", "binding", "buffer", "was", "added", "to", "the", "culture", "tube", ",", "which", "was", "subsequently", "analyzed", "after", "10", "to", "15", "minutes", "using", "flow", "cytometry", "." ] } ]
PMC6024716	Improved protein expression is often accompanied by undesirable side effects, such as growth and metabolic disadvantages , caused by increased metabolic load on the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Improved", "protein", "expression", "is", "often", "accompanied", "by", "undesirable", "side", "effects", ",", "such", "as", "growth", "and", "metabolic", "disadvantages", ",", "caused", "by", "increased", "metabolic", "load", "on", "the", "cells", "." ] } ]
PMC10547921	This research provides a new understanding of the factors controlling DNA alkylation rates by these compounds and the importance of DNA-binding-induced activation of the alkylation reaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "research", "provides", "a", "new", "understanding", "of", "the", "factors", "controlling", "DNA", "alkylation", "rates", "by", "these", "compounds", "and", "the", "importance", "of", "DNA-binding-induced", "activation", "of", "the", "alkylation", "reaction", "." ] } ]
PMC9429973	After a median follow-up of 9 months (1-24) from the start of HMAs therapy, 144 (63%) pts died and 86 (37%) were alive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "a", "median", "follow-up", "of", "9", "months", "(", "1", "-", "24", ")", "from", "the", "start", "of", "HMAs", "therapy", ",", "144", "(", "63", "%", ")", "pts", "died", "and", "86", "(", "37", "%", ")", "were", "alive", "." ] } ]
PMC10988808	E Representative images and bar graphs of Transwell migration assays of Caki-1 and 786–0 cells after overexpression CCDC25 (p < 0.01, *p < 0.001,).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "Representative", "images", "and", "bar", "graphs", "of", "Transwell", "migration", "assays", "of", "Caki-1", "and", "786–0", "cells", "after", "overexpression", "CCDC25", "(", "", "", "p", "<", "0.01", ",", "", "", "*", "p", "<", "0.001", ",", ")", "." ] } ]
PMC9429973	Multiparametric flow cytometry was applied to explore surface marker expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Multiparametric", "flow", "cytometry", "was", "applied", "to", "explore", "surface", "marker", "expression", "." ] } ]
PMC11585254	Parental HEK293 cells and β-arrestin1 and β-arrestin2 double-knockout (DKO) HEK293 cells were from Dr. Asuka Inoue (Tohoku University, Japan).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Parental", "HEK293", "cells", "and", "β-arrestin1", "and", "β-arrestin2", "double-knockout", "(", "DKO", ")", "HEK293", "cells", "were", "from", "Dr.", "Asuka", "Inoue", "(", "Tohoku", "University", ",", "Japan", ")", "." ] } ]
PMC11655536	Interestingly, HA treatment didn’t show a prominent effect on mice body weights, alanine aminotransferase, total protein and creatine kinase (Fig. S5B, C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "HA", "treatment", "did", "n’t", "show", "a", "prominent", "effect", "on", "mice", "body", "weights", ",", "alanine", "aminotransferase", ",", "total", "protein", "and", "creatine", "kinase", "(", "Fig.", "S5B", ",", "C", ")", "." ] } ]
PMC8358006	In conclusion, by exploring epigenetic changes associated with tumorigenesis in ESCC cell line, we discovered that for carcinogenic sets, characterized by loss of grand H3K27me3 domains, their expression levels are raised in cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "by", "exploring", "epigenetic", "changes", "associated", "with", "tumorigenesis", "in", "ESCC", "cell", "line", ",", "we", "discovered", "that", "for", "carcinogenic", "sets", ",", "characterized", "by", "loss", "of", "grand", "H3K27me3", "domains", ",", "their", "expression", "levels", "are", "raised", "in", "cancer", "." ] } ]
PMC11790971	While this study has provided valuable insights into the applicability of multimodal optical imaging for biopharmaceutical cell line classification, several limitations must be noted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "this", "study", "has", "provided", "valuable", "insights", "into", "the", "applicability", "of", "multimodal", "optical", "imaging", "for", "biopharmaceutical", "cell", "line", "classification", ",", "several", "limitations", "must", "be", "noted", "." ] } ]
PMC11502327	As a natural medicine widely studied in clinical studies, the challenges restricting the clinical application of curcumin mainly come from its low stability and low solubility in solution, as well as poor absorption in the intestines and rapid metabolism after oral administration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "natural", "medicine", "widely", "studied", "in", "clinical", "studies", ",", "the", "challenges", "restricting", "the", "clinical", "application", "of", "curcumin", "mainly", "come", "from", "its", "low", "stability", "and", "low", "solubility", "in", "solution", ",", "as", "well", "as", "poor", "absorption", "in", "the", "intestines", "and", "rapid", "metabolism", "after", "oral", "administration", "." ] } ]
PMC11519077	Furthermore, the NOD2 gene's expression level diminished when comparing the MB-CM group to the control group, although this difference is not statistically significant (0.93 ± 0.501; p = 0.903).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "NOD2", "gene", "'s", "expression", "level", "diminished", "when", "comparing", "the", "MB-CM", "group", "to", "the", "control", "group", ",", "although", "this", "difference", "is", "not", "statistically", "significant", "(", "0.93", "±", "0.501", ";", "p", "=", "0.903", ")", "." ] } ]
PMC9024365	Additional experiments will address this possibility.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "experiments", "will", "address", "this", "possibility", "." ] } ]
PMC9878562	However, the reduced migration of VAL-ko could also result from the lower number of VAL-wt migrating in the mixture.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "reduced", "migration", "of", "VAL-ko", "could", "also", "result", "from", "the", "lower", "number", "of", "VAL-wt", "migrating", "in", "the", "mixture", "." ] } ]
PMC8357004	The mammalian cell cycle is controlled and governed by the kinase complexes including cyclin, as a regulatory subunit, and the cyclin-dependent kinase (CDK), as a catalytic subunit together named cyclin-CDK complexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mammalian", "cell", "cycle", "is", "controlled", "and", "governed", "by", "the", "kinase", "complexes", "including", "cyclin", ",", "as", "a", "regulatory", "subunit", ",", "and", "the", "cyclin-dependent", "kinase", "(", "CDK", ")", ",", "as", "a", "catalytic", "subunit", "together", "named", "cyclin-CDK", "complexes", "." ] } ]
PMC11518702	Possible effects on cell adhesion (and contributing proteins) will also be meaningful to investigate, together with assessments of primary human DLBCL B-cell migration using B cells from patients with high vs. moderate HGAL expression levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Possible", "effects", "on", "cell", "adhesion", "(", "and", "contributing", "proteins", ")", "will", "also", "be", "meaningful", "to", "investigate", ",", "together", "with", "assessments", "of", "primary", "human", "DLBCL", "B-cell", "migration", "using", "B", "cells", "from", "patients", "with", "high", "vs.", "moderate", "HGAL", "expression", "levels", "." ] } ]
PMC9429973	Statistical analysis was done by using Mann-Whitney and Wilcoxon tests, differences between groups were considered significant if p<0.05.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analysis", "was", "done", "by", "using", "Mann-Whitney", "and", "Wilcoxon", "tests", ",", "differences", "between", "groups", "were", "considered", "significant", "if", "p<0.05", "." ] } ]
PMC11803918	In summary, this project offers a promising approach by combining γδ-T exosomes with PDT for potent photoimmunotherapy and expands the potential clinical applications of γδ-T exosome therapy in cancer patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "summary", ",", "this", "project", "offers", "a", "promising", "approach", "by", "combining", "γδ-T", "exosomes", "with", "PDT", "for", "potent", "photoimmunotherapy", "and", "expands", "the", "potential", "clinical", "applications", "of", "γδ-T", "exosome", "therapy", "in", "cancer", "patients", "." ] } ]
PMC11760643	Written informed consent has been obtained from the donors to publish this paper.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Written", "informed", "consent", "has", "been", "obtained", "from", "the", "donors", "to", "publish", "this", "paper", "." ] } ]
PMC10093184	Indeed, by comparing migration and invasion abilities, the invasion index was calculated as follows: 71% (COS3600), 77% (COS3600B), 46% (COS4074), 61% (COS4288), and finally 87% (D-17).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Indeed", ",", "by", "comparing", "migration", "and", "invasion", "abilities", ",", "the", "invasion", "index", "was", "calculated", "as", "follows", ":", "71", "%", "(", "COS3600", ")", ",", "77", "%", "(", "COS3600B", ")", ",", "46", "%", "(", "COS4074", ")", ",", "61", "%", "(", "COS4288", ")", ",", "and", "finally", "87", "%", "(", "D-17", ")", "." ] } ]
PMC11650848	In untreated cells, the average methylation was 60% which decreased to below 40% after Aza treatment (red bars, p = 0.014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "untreated", "cells", ",", "the", "average", "methylation", "was", "60", "%", "which", "decreased", "to", "below", "40", "%", "after", "Aza", "treatment", "(", "red", "bars", ",", "p", "=", "0.014", ")", "." ] } ]
PMC7823217	Laser-based bioprinting facilitates high-precision patterning or fabrication of tissue constructs with the help of laser energy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Laser-based", "bioprinting", "facilitates", "high-precision", "patterning", "or", "fabrication", "of", "tissue", "constructs", "with", "the", "help", "of", "laser", "energy", "." ] } ]
PMC5716223	Here, we verified the role of NGF in the growth, survival and differentiation of p75-expressing L6C5 myogenic cells, specifically inquiring for the putative involvement of the nuclear factor κB (NFκB) and the small heat shock proteins (sHSPs) αB-crystallin and Hsp27 in these processes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "verified", "the", "role", "of", "NGF", "in", "the", "growth", ",", "survival", "and", "differentiation", "of", "p75-expressing", "L6C5", "myogenic", "cells", ",", "specifically", "inquiring", "for", "the", "putative", "involvement", "of", "the", "nuclear", "factor", "κB", "(", "NFκB", ")", "and", "the", "small", "heat", "shock", "proteins", "(", "sHSPs", ")", "αB-crystallin", "and", "Hsp27", "in", "these", "processes", "." ] } ]
PMC9429973	The PROGENy analysis of the basal activity of selected cancer-related pathways in untreated cells pointed to the different regulation of the hypoxic pathway: the activity of hypoxic pathway in profile II samples was in between high levels found in TP53 mutants and low levels in profile I. Finally, we have found ATM locus/gene defects more frequently in profile II.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PROGENy", "analysis", "of", "the", "basal", "activity", "of", "selected", "cancer-related", "pathways", "in", "untreated", "cells", "pointed", "to", "the", "different", "regulation", "of", "the", "hypoxic", "pathway", ":", "the", "activity", "of", "hypoxic", "pathway", "in", "profile", "II", "samples", "was", "in", "between", "high", "levels", "found", "in", "TP53", "mutants", "and", "low", "levels", "in", "profile", "I.", "Finally", ",", "we", "have", "found", "ATM", "locus/gene", "defects", "more", "frequently", "in", "profile", "II", "." ] } ]
PMC11525028	The primers used are listed in Table S8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primers", "used", "are", "listed", "in", "Table", "S8", "." ] } ]
PMC11612315	g Mean normalized 340/380 ratios of sequential CAP-induced calcium increases (mean ± S.E.M.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", "Mean", "normalized", "340/380", "ratios", "of", "sequential", "CAP-induced", "calcium", "increases", "(", "mean", "±", "S.E.M.", ")", "." ] } ]
PMC11698348	SCs were then wash in PBS and fixed with 4% PFA for 1 hour at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SCs", "were", "then", "wash", "in", "PBS", "and", "fixed", "with", "4", "%", "PFA", "for", "1", "hour", "at", "room", "temperature", "." ] } ]
PMC11001582	n = 3 independent biological replicates, one-way ANOVA, Bonferroni’s multiple comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "3", "independent", "biological", "replicates", ",", "one-way", "ANOVA", ",", "Bonferroni", "’s", "multiple", "comparison", "." ] } ]
PMC9712534	The graphs of WT and H58Y are same as those in Fig. 2C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "graphs", "of", "WT", "and", "H58Y", "are", "same", "as", "those", "in", "Fig.", "2C", "." ] } ]
PMC5925824	The clinical validation of targeting the PD-1/PD-L1 axis demonstrated by inhibition of the PD-1 receptor, has also led to the clinical development and regulatory approval of multiple molecules that block the PD-L1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "clinical", "validation", "of", "targeting", "the", "PD-1/PD-L1", "axis", "demonstrated", "by", "inhibition", "of", "the", "PD-1", "receptor", ",", "has", "also", "led", "to", "the", "clinical", "development", "and", "regulatory", "approval", "of", "multiple", "molecules", "that", "block", "the", "PD-L1", "." ] } ]
PMC11300639	In addition, abemaciclib alone or in combination with sunitinib led to the regression of 786-O xenografts, and tumor regression was also observed when abemaciclib was added after sunitinib pretreatment .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "abemaciclib", "alone", "or", "in", "combination", "with", "sunitinib", "led", "to", "the", "regression", "of", "786-O", "xenografts", ",", "and", "tumor", "regression", "was", "also", "observed", "when", "abemaciclib", "was", "added", "after", "sunitinib", "pretreatment", "." ] } ]
PMC11577421	NP_BSA+ dispersed in PBS buffer was injected into the flow at concentrations ranging from 0.00625 to 0.2 nM, and the flow rate was 60 μL min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NP_BSA+", "dispersed", "in", "PBS", "buffer", "was", "injected", "into", "the", "flow", "at", "concentrations", "ranging", "from", "0.00625", "to", "0.2", "nM", ",", "and", "the", "flow", "rate", "was", "60", "μL", "min", "." ] } ]
PMC11727062	This, in turn, inhibits the invasiveness of BRAF-mutant melanomas, thereby exerting an antitumor effect (de Souza et al. 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ",", "in", "turn", ",", "inhibits", "the", "invasiveness", "of", "BRAF-mutant", "melanomas", ",", "thereby", "exerting", "an", "antitumor", "effect", "(", "de", "Souza", "et", "al.", "2020", ")", "." ] } ]
PMC11680562	Clinical studies are essential for assessing the gel's efficacy in real-life situations and determining the most appropriate dose and frequency of administration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clinical", "studies", "are", "essential", "for", "assessing", "the", "gel", "'s", "efficacy", "in", "real-life", "situations", "and", "determining", "the", "most", "appropriate", "dose", "and", "frequency", "of", "administration", "." ] } ]
PMC11746942	It has been reported that the S1P level in the serum of psoriasis patients is increased , and S1PR1-3 is ubiquitously expressed .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "reported", "that", "the", "S1P", "level", "in", "the", "serum", "of", "psoriasis", "patients", "is", "increased", ",", "and", "S1PR1", "-", "3", "is", "ubiquitously", "expressed", "." ] } ]
PMC9429973	Estimated PFS at 24 months was 90.8% (95% CI 82.0%-99.6%) (Figure).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Estimated", "PFS", "at", "24", "months", "was", "90.8", "%", "(", "95", "%", "CI", "82.0%-99.6", "%", ")", "(", "Figure", ")", "." ] } ]
PMC5673955	Genomic DNA was isolated using PureLink Genomic DNA Mini Kit (Thermo Scientific Inc.) and real‐time PCR was performed 28.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genomic", "DNA", "was", "isolated", "using", "PureLink", "Genomic", "DNA", "Mini", "Kit", "(", "Thermo", "Scientific", "Inc.", ")", "and", "real‐time", "PCR", "was", "performed", "28", "." ] } ]
PMC11095939	Subsequently, AAV vector particles were purified by ultracentrifugation in an iodixanol density gradient at 350,000 × g for 2 hr at 18°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "AAV", "vector", "particles", "were", "purified", "by", "ultracentrifugation", "in", "an", "iodixanol", "density", "gradient", "at", "350,000", "×", "g", "for", "2", "hr", "at", "18", "°", "C", "." ] } ]
PMC11594588	The same adduct was later also found in human breast and leukocytes by Vaca et al. .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "same", "adduct", "was", "later", "also", "found", "in", "human", "breast", "and", "leukocytes", "by", "Vaca", "et", "al.", "." ] } ]
PMC8164677	Cell survival fraction values at different administered doses of cisplatin and wedelolactone in the case of all three cell lines are given in Figure 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "survival", "fraction", "values", "at", "different", "administered", "doses", "of", "cisplatin", "and", "wedelolactone", "in", "the", "case", "of", "all", "three", "cell", "lines", "are", "given", "in", "Figure", "3", "." ] } ]
PMC11640476	The images clearly showed that as the number of treatments with resazurin increases, the number of cells decreases, and their morphology worsens (Figure 6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "images", "clearly", "showed", "that", "as", "the", "number", "of", "treatments", "with", "resazurin", "increases", ",", "the", "number", "of", "cells", "decreases", ",", "and", "their", "morphology", "worsens", "(", "Figure", "6C", ")", "." ] } ]
PMC11644761	Among the stilbenoids, resveratrol (trans-3,5,4′-trihydroxystilbene) and pterostilbene (trans-3,5-dimethoxy-4′-hydroxystilbene) are the most well-known representatives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "the", "stilbenoids", ",", "resveratrol", "(", "trans-3,5,4′-trihydroxystilbene", ")", "and", "pterostilbene", "(", "trans-3,5-dimethoxy-4′-hydroxystilbene", ")", "are", "the", "most", "well-known", "representatives", "." ] } ]
PMC11696576	In whole blood, bacterial lipopolysaccharide (LPS) stimulated the release of PGE2, thromboxane B2 (TXB2), and 15-hydroxyeicosatetraenoic acid (HETE).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "whole", "blood", ",", "bacterial", "lipopolysaccharide", "(", "LPS", ")", "stimulated", "the", "release", "of", "PGE2", ",", "thromboxane", "B2", "(", "TXB2", ")", ",", "and", "15-hydroxyeicosatetraenoic", "acid", "(", "HETE", ")", "." ] } ]
PMC11240052	Down-regulation of circ-0008285 caused cell proliferation suppuration in the A2780 cell line. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Down-regulation", "of", "circ-0008285", "caused", "cell", "proliferation", "suppuration", "in", "the", "A2780", "cell", "line", ".", "(" ] } ]
PMC10999934	The differentially expressed genes (DEGs) between malignant epithelial cells associated with chemoresistance and those not associated with chemoresistance. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "differentially", "expressed", "genes", "(", "DEGs", ")", "between", "malignant", "epithelial", "cells", "associated", "with", "chemoresistance", "and", "those", "not", "associated", "with", "chemoresistance", ".", "(" ] } ]
PMC9516401	Before 2010 when selective IDE inhibitors were developed (Leissring et al., 2010 ▶), compelling lines of studies used non-specific inhibitors of IDE such as zinc-chelators, thiol-alkylating compounds, and the cyclic peptide bacitracin to reduce the activity of IDE (Leissring et al., 2021 ▶).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Before", "2010", "when", "selective", "IDE", "inhibitors", "were", "developed", "(", "Leissring", "et", "al.", ",", "2010", "▶", ")", ",", "compelling", "lines", "of", "studies", "used", "non-specific", "inhibitors", "of", "IDE", "such", "as", "zinc-chelators", ",", "thiol-alkylating", "compounds", ",", "and", "the", "cyclic", "peptide", "bacitracin", "to", "reduce", "the", "activity", "of", "IDE", "(", "Leissring", "et", "al.", ",", "2021", "▶", ")", "." ] } ]
PMC9429973	Of these, 1 pt had been vaccinated (Moderna, 2 doses; >6 months prior to infection) and 3 pts received concomitant medication to treat COVID-19 infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "these", ",", "1", "pt", "had", "been", "vaccinated", "(", "Moderna", ",", "2", "doses", ";", ">", "6", "months", "prior", "to", "infection", ")", "and", "3", "pts", "received", "concomitant", "medication", "to", "treat", "COVID-19", "infection", "." ] } ]
PMC11772449	J-K: Knockdown of ATG5 can enhance the inhibitory effect of Sora on the proliferation of hepatocellular carcinoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "J-K", ":", "Knockdown", "of", "ATG5", "can", "enhance", "the", "inhibitory", "effect", "of", "Sora", "on", "the", "proliferation", "of", "hepatocellular", "carcinoma", "cells", "." ] } ]
PMC11657744	Our findings demonstrate the specialized roles of DA proteins in ciliary assembly and disassembly, with a particular link between CEP89/FBF1 and Aurora A kinase regulation in disassembly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "demonstrate", "the", "specialized", "roles", "of", "DA", "proteins", "in", "ciliary", "assembly", "and", "disassembly", ",", "with", "a", "particular", "link", "between", "CEP89/FBF1", "and", "Aurora", "A", "kinase", "regulation", "in", "disassembly", "." ] } ]
PMC10440586	For analyses requiring assignment to a single subtype for each sample, we considered the subtype with the lowest P value.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "analyses", "requiring", "assignment", "to", "a", "single", "subtype", "for", "each", "sample", ",", "we", "considered", "the", "subtype", "with", "the", "lowest", "P", "value", "." ] } ]
PMC11787651	The lysate was centrifuged, and the pellet was washed to remove detergent and cytoplasmic contents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "lysate", "was", "centrifuged", ",", "and", "the", "pellet", "was", "washed", "to", "remove", "detergent", "and", "cytoplasmic", "contents", "." ] } ]
PMC11756907	The post-reaction suspension was diluted with water, and then hydrogen peroxide was added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "post-reaction", "suspension", "was", "diluted", "with", "water", ",", "and", "then", "hydrogen", "peroxide", "was", "added", "." ] } ]
PMC9429973	P. Ntziachristos, Q. Jin, B. Gutierrez Ghent University, Ghent, Belgium; MD Anderson, Houston; Northwestern University, Chicago, United States of America Background: Dysregulation of kinase signaling pathways via mutations favors tumor cell survival and resistance to therapy and it is common in cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P.", "Ntziachristos", ",", "Q.", "Jin", ",", "B.", "Gutierrez", "Ghent", "University", ",", "Ghent", ",", "Belgium", ";", "MD", "Anderson", ",", "Houston", ";", "Northwestern", "University", ",", "Chicago", ",", "United", "States", "of", "America", "Background", ":", "Dysregulation", "of", "kinase", "signaling", "pathways", "via", "mutations", "favors", "tumor", "cell", "survival", "and", "resistance", "to", "therapy", "and", "it", "is", "common", "in", "cancer", "." ] } ]
PMC9429973	SM-AHN patients were identified using inclusion/exclusion criteria similar to the EXPLORER and PATHFINDER trials.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SM-AHN", "patients", "were", "identified", "using", "inclusion/exclusion", "criteria", "similar", "to", "the", "EXPLORER", "and", "PATHFINDER", "trials", "." ] } ]
PMC11783017	However, it observed that the internalization of both Lipo and Lipo-IL11 was more obvious in 143B cells than that in L929 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "However", ",", "it", "observed", "that", "the", "internalization", "of", "both", "Lipo", "and", "Lipo-IL11", "was", "more", "obvious", "in", "143B", "cells", "than", "that", "in", "L929", "cells", "." ] } ]
PMC11206251	In order to further study the mechanism of the PEIM against HCC, Western blot assay was used to detect the expression of TLR4/MyD88/NF-κB, JAK2/STAT3, P53/P21/MDM2, and mitochondrial apoptosis pathway-related proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "order", "to", "further", "study", "the", "mechanism", "of", "the", "PEIM", "against", "HCC", ",", "Western", "blot", "assay", "was", "used", "to", "detect", "the", "expression", "of", "TLR4/MyD88/NF-κB", ",", "JAK2/STAT3", ",", "P53/P21/MDM2", ",", "and", "mitochondrial", "apoptosis", "pathway-related", "proteins", "." ] } ]
PMC6222635	We therefore advise that the planting mode of Dendrobium officinale should be improved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "therefore", "advise", "that", "the", "planting", "mode", "of", "Dendrobium", "officinale", "should", "be", "improved", "." ] } ]

PMC10507284

Generally, tumor immune cell infiltration is recognized as an independent predictor of tumor immune status and survival.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Generally", ",", "tumor", "immune", "cell", "infiltration", "is", "recognized", "as", "an", "independent", "predictor", "of", "tumor", "immune", "status", "and", "survival", "." ] } ]

PMC9727330

NNDAsp stimulates IL-1α and IL-1β expression in colon cancer cells To determine the correlation between NNDAsp treatment and produced inflammatory cytokines from treated cells, IL-1α and IL-1β were measured in a time-course experiment using ELISA assay.

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PMC3734024

Intriguingly, despite the vast difference in their killing activity there is no consistent difference in FasL protein levels (on a per cell basis) between B cells stimulated with IL-5 and CD40L and those stimulated with IL-4, IL-5, and CD40L (Figure 8B).

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PMC11462673

The T-ALL cell lines utilized in our experiments include Jurkat, 6 T-CEM, J.gamma1, Molt4, PF-382, and others.

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PMC11098378

We envision that our screening methodology can further identify unique IEPs targeting conserved pathways for a variety of pathogen-encoded proteins.

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PMC11747949

Lastly, we show the benefits of the tumor cell‐PBMC coculture model as a tool to better delineate the tumor cell phenotypes compared to mono‐cultures.

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PMC10998613

The PIE-FCCS results we reported here reveal a more complicated interaction scheme than a simple monomer-dimer equilibrium for CXCR4 and β2AR.

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PMC11772585

However, further investigation is needed to understand the differential expression of METTL1 in cSCC and the role of m7G modification in the development of this tumor type.

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PMC11694625

Based on this, we chose the liver and kidneys for biochemical experiments, where the evaluation indicators for the liver were ALT and AST, and the evaluation indicators for the kidneys were urea and creatinine.

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PMC11694066

siRNA-mediated knockdown of PARP1 conferred resistance to PARPi in JN1 but not R cells (Supplementary Fig. S4B–S4E).

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PMC11366496

Kaplan–Meier analysis showed a poorer prognosis for patients with RNF122 overexpression (Figure 1F,G).

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PMC9429973

1-year survival rates were 61.1% (95% CI: 42.9, 75.0) overall, 66.8% (95% CI: 32.4, 86.6) for HCT, and 57.4% (95% CI: 35.2, 74.5) for SOT.

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PMC9429973

Summary/Conclusion: In our study histological subtype and type of treatment, but not antiviral therapies, had prognostic impact on the outcome of SARS COV 2 infection in patients with lymphoproliferative disorders during the current phase of pandemic.

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PMC11596967

This is achieved by improving the peptide’s solubility in lipid environments and accessibility to fat-soluble ROS and polyunsaturated fatty acids .

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PMC9966931

At 0.125%, (4) nearly lost its activity completely, but it became clear which hybrids from cinnamic acid exerted higher antifungal effects.

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PMC9412887

Nanomedicines under 5 nm mainly accumulate in kidney.

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PMC9341513

From the images, we obtain the 3D volumes of the probes; a similar measure is obtained from the simulations.

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PMC11672617

The release of cytochrome c and other pro-apoptotic proteins into the cytosol is a key event in the initiation of the intrinsic (mitochondrial) pathway of cell death, which is triggered by the induction of various types of apoptosis and related events, namely, mitochondrial depolarization and cardiolipin peroxidation.

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PMC11615828

a,d) The fluorescence images show the distribution of the indicated vesicles in COS7 cells.

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PMC11295144

It is now evident that together with many other proteins, GABAARs and NL2 undergo complex interactions to facilitate synaptic contact formation but how these interactions are coordinated in time and space to lead to the establishment of fully functional inhibitory synapses remains to be described in detail.

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PMC11486946

d Immuno-fluorescent images of EGFR in A431, Ba/F3 expressing EGFR, and HeLa cells acquired at 1 h after the compound treatment.

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PMC10547921

In a HER2 expressing mouse xenograft model (SK-OV-3ip), a single intravenous ADC dose (5 mg/kg) can cause tumor growth to stop for 3 weeks, better than Kadcyla (5 mg/kg).

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PMC11746948

a Schematic of the workflow for identifying palmitoylated proteins using the click chemistry assay and LC-MS/MS.

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PMC10969097

All references were exported to the Rayyan systematic review data management platform (https://www.rayyan.ai) .

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PMC10758402

786-0 cells were treated with 150 μM of DMF at various times before or after infection with HSV.n212 (MOI: 0.01) or untreated.

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PMC11787651

For the transition settings, precursor and product ion mass were set as monoisotopic, with filters for precursor charges 2 to 4, product ion charge 1, and ion types y, b, and p. A minimum of m/z 50 and a maximum of m/z 1500 with a method-match tolerance of m/z 0.055 were used for the instrument settings.

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PMC10253973

The results also suggested that a high number of intercalating aromatic rings increased the binding affinity towards the DNA receptors.

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PMC9429973

C. Almeida, R. Costa e Sousa, C. Afonso, A. Roque, D. Luis, L. Araujo, C. Geraldes Hematology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal Background: Hairy cell leukemia (HCL) is an indolent and uncommon chronic B cell lymphoproliferative disorder.

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PMC9848491

As far as diagnostic efficacy is concerned, their results are comparable to ours.

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PMC2196094

Blotting with a VacuBlot unit (Pharmacia, Uppsala, Sweden) was completed in 3 h and the DNA was cross-linked to the membrane by UV-irradiation (GS Gene Linker; BioRad Laboratories, Hercules, CA).

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PMC8409415

A significantly higher percentage of mitotic cells was observed in the CD70‐ADC‐treated than in the control‐ADC group (6.40% [IQR 4.85%‐7.0%] vs 3.48% [IQR 3.0%‐4.0%], P < .01) (Figure 6G, H).

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PMC9541067

d Quantitative analysis to (c).

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PMC11525028

For puromycin assay, cells were treated with puromycin at a final concentration of 1 μM for 30 min.

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PMC11711347

The presence of a C=N group is revealed by a peak at 1595 cm .

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PMC9429973

Figure 1).

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PMC11588008

This result indicated that the ERK–Nrf2–HO-1 pathway mediated the protective effects of HUC-MSCs on PM-injured cells.

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PMC11650848

A further area of exploration could be into the evolutionary timeline of these ZFP57 isoforms.

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PMC11531744

This heatmap consisted of blue blocks along the diagonal with the white background.

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PMC9895440

FindMarkers in Seurat was used to calculate differentially expressed genes for each cluster and for all cells in total between Snx9 KO and intergenic.

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PMC11629461

The miniSOG after absorbing blue light (LED 450 nm) produces O2 at a ФΔ of ≥0.03. ,

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PMC9429973

However, between 5-40% of patients fail to obtain an adequate collection of hematopoietic progenitor cells (HPCs), this is known as mobilization failure.

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PMC11769522

Accordingly, 100 µL of the cell culture supernatant was used for the analysis of IL-6 concentrations.

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PMC11802855

The observations also revealed that the expression levels of MMP2, MMP9, and MMP13 in the bone tissue of mice in the OE group were significantly elevated.

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PMC10919056

Finally, 400 μL of binding buffer was added to the culture tube, which was subsequently analyzed after 10 to 15 minutes using flow cytometry.

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PMC6024716

Improved protein expression is often accompanied by undesirable side effects, such as growth and metabolic disadvantages , caused by increased metabolic load on the cells.

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PMC10547921

This research provides a new understanding of the factors controlling DNA alkylation rates by these compounds and the importance of DNA-binding-induced activation of the alkylation reaction.

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PMC9429973

After a median follow-up of 9 months (1-24) from the start of HMAs therapy, 144 (63%) pts died and 86 (37%) were alive.

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PMC10988808

E Representative images and bar graphs of Transwell migration assays of Caki-1 and 786–0 cells after overexpression CCDC25 (**p < 0.01, ***p < 0.001,).

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PMC9429973

Multiparametric flow cytometry was applied to explore surface marker expression.

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PMC11585254

Parental HEK293 cells and β-arrestin1 and β-arrestin2 double-knockout (DKO) HEK293 cells were from Dr. Asuka Inoue (Tohoku University, Japan).

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PMC11655536

Interestingly, HA treatment didn’t show a prominent effect on mice body weights, alanine aminotransferase, total protein and creatine kinase (Fig. S5B, C).

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PMC8358006

In conclusion, by exploring epigenetic changes associated with tumorigenesis in ESCC cell line, we discovered that for carcinogenic sets, characterized by loss of grand H3K27me3 domains, their expression levels are raised in cancer.

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PMC11790971

While this study has provided valuable insights into the applicability of multimodal optical imaging for biopharmaceutical cell line classification, several limitations must be noted.

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PMC11502327

As a natural medicine widely studied in clinical studies, the challenges restricting the clinical application of curcumin mainly come from its low stability and low solubility in solution, as well as poor absorption in the intestines and rapid metabolism after oral administration.

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PMC11519077

Furthermore, the NOD2 gene's expression level diminished when comparing the MB-CM group to the control group, although this difference is not statistically significant (0.93 ± 0.501; p = 0.903).

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PMC9024365

Additional experiments will address this possibility.

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PMC9878562

However, the reduced migration of VAL-ko could also result from the lower number of VAL-wt migrating in the mixture.

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PMC8357004

The mammalian cell cycle is controlled and governed by the kinase complexes including cyclin, as a regulatory subunit, and the cyclin-dependent kinase (CDK), as a catalytic subunit together named cyclin-CDK complexes.

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PMC11518702

Possible effects on cell adhesion (and contributing proteins) will also be meaningful to investigate, together with assessments of primary human DLBCL B-cell migration using B cells from patients with high vs. moderate HGAL expression levels.

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PMC9429973

Statistical analysis was done by using Mann-Whitney and Wilcoxon tests, differences between groups were considered significant if p<0.05.

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PMC11803918

In summary, this project offers a promising approach by combining γδ-T exosomes with PDT for potent photoimmunotherapy and expands the potential clinical applications of γδ-T exosome therapy in cancer patients.

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PMC11760643

Written informed consent has been obtained from the donors to publish this paper.

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PMC10093184

Indeed, by comparing migration and invasion abilities, the invasion index was calculated as follows: 71% (COS3600), 77% (COS3600B), 46% (COS4074), 61% (COS4288), and finally 87% (D-17).

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PMC11650848

In untreated cells, the average methylation was 60% which decreased to below 40% after Aza treatment (red bars, p = 0.014).

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PMC7823217

Laser-based bioprinting facilitates high-precision patterning or fabrication of tissue constructs with the help of laser energy.

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PMC5716223

Here, we verified the role of NGF in the growth, survival and differentiation of p75-expressing L6C5 myogenic cells, specifically inquiring for the putative involvement of the nuclear factor κB (NFκB) and the small heat shock proteins (sHSPs) αB-crystallin and Hsp27 in these processes.

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PMC9429973

The PROGENy analysis of the basal activity of selected cancer-related pathways in untreated cells pointed to the different regulation of the hypoxic pathway: the activity of hypoxic pathway in profile II samples was in between high levels found in TP53 mutants and low levels in profile I. Finally, we have found ATM locus/gene defects more frequently in profile II.

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PMC11525028

The primers used are listed in Table S8.

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PMC11612315

g Mean normalized 340/380 ratios of sequential CAP-induced calcium increases (mean ± S.E.M.).

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PMC11698348

SCs were then wash in PBS and fixed with 4% PFA for 1 hour at room temperature.

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PMC11001582

n = 3 independent biological replicates, one-way ANOVA, Bonferroni’s multiple comparison.

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PMC9712534

The graphs of WT and H58Y are same as those in Fig. 2C.

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PMC5925824

The clinical validation of targeting the PD-1/PD-L1 axis demonstrated by inhibition of the PD-1 receptor, has also led to the clinical development and regulatory approval of multiple molecules that block the PD-L1.

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PMC11300639

In addition, abemaciclib alone or in combination with sunitinib led to the regression of 786-O xenografts, and tumor regression was also observed when abemaciclib was added after sunitinib pretreatment .

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PMC11577421

NP_BSA+ dispersed in PBS buffer was injected into the flow at concentrations ranging from 0.00625 to 0.2 nM, and the flow rate was 60 μL min.

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PMC11727062

This, in turn, inhibits the invasiveness of BRAF-mutant melanomas, thereby exerting an antitumor effect (de Souza et al. 2020).

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PMC11680562

Clinical studies are essential for assessing the gel's efficacy in real-life situations and determining the most appropriate dose and frequency of administration.

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PMC11746942

It has been reported that the S1P level in the serum of psoriasis patients is increased , and S1PR1-3 is ubiquitously expressed .

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PMC9429973

Estimated PFS at 24 months was 90.8% (95% CI 82.0%-99.6%) (Figure).

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PMC5673955

Genomic DNA was isolated using PureLink Genomic DNA Mini Kit (Thermo Scientific Inc.) and real‐time PCR was performed 28.

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PMC11095939

Subsequently, AAV vector particles were purified by ultracentrifugation in an iodixanol density gradient at 350,000 × g for 2 hr at 18°C.

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PMC11594588

The same adduct was later also found in human breast and leukocytes by Vaca et al. .

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PMC8164677

Cell survival fraction values at different administered doses of cisplatin and wedelolactone in the case of all three cell lines are given in Figure 3.

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PMC11640476

The images clearly showed that as the number of treatments with resazurin increases, the number of cells decreases, and their morphology worsens (Figure 6C).

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PMC11644761

Among the stilbenoids, resveratrol (trans-3,5,4′-trihydroxystilbene) and pterostilbene (trans-3,5-dimethoxy-4′-hydroxystilbene) are the most well-known representatives.

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PMC11696576

In whole blood, bacterial lipopolysaccharide (LPS) stimulated the release of PGE2, thromboxane B2 (TXB2), and 15-hydroxyeicosatetraenoic acid (HETE).

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PMC11240052

Down-regulation of circ-0008285 caused cell proliferation suppuration in the A2780 cell line. (

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PMC10999934

The differentially expressed genes (DEGs) between malignant epithelial cells associated with chemoresistance and those not associated with chemoresistance. (

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PMC9516401

Before 2010 when selective IDE inhibitors were developed (Leissring et al., 2010 ▶), compelling lines of studies used non-specific inhibitors of IDE such as zinc-chelators, thiol-alkylating compounds, and the cyclic peptide bacitracin to reduce the activity of IDE (Leissring et al., 2021 ▶).

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PMC9429973

Of these, 1 pt had been vaccinated (Moderna, 2 doses; >6 months prior to infection) and 3 pts received concomitant medication to treat COVID-19 infection.

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PMC11772449

J-K: Knockdown of ATG5 can enhance the inhibitory effect of Sora on the proliferation of hepatocellular carcinoma cells.

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PMC11657744

Our findings demonstrate the specialized roles of DA proteins in ciliary assembly and disassembly, with a particular link between CEP89/FBF1 and Aurora A kinase regulation in disassembly.

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PMC10440586

For analyses requiring assignment to a single subtype for each sample, we considered the subtype with the lowest P value.

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PMC11787651

The lysate was centrifuged, and the pellet was washed to remove detergent and cytoplasmic contents.

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PMC11756907

The post-reaction suspension was diluted with water, and then hydrogen peroxide was added.

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PMC9429973

P. Ntziachristos, Q. Jin, B. Gutierrez Ghent University, Ghent, Belgium; MD Anderson, Houston; Northwestern University, Chicago, United States of America Background: Dysregulation of kinase signaling pathways via mutations favors tumor cell survival and resistance to therapy and it is common in cancer.

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PMC9429973

SM-AHN patients were identified using inclusion/exclusion criteria similar to the EXPLORER and PATHFINDER trials.

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PMC11783017

However, it observed that the internalization of both Lipo and Lipo-IL11 was more obvious in 143B cells than that in L929 cells.

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PMC11206251

In order to further study the mechanism of the PEIM against HCC, Western blot assay was used to detect the expression of TLR4/MyD88/NF-κB, JAK2/STAT3, P53/P21/MDM2, and mitochondrial apoptosis pathway-related proteins.

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PMC6222635

We therefore advise that the planting mode of Dendrobium officinale should be improved.

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