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OTAR3088
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BioData-CellLine_annotated

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PMC6461034
A scatter plot is created for kinases observed and/or inferred in the sample, with the INKA score on the vertical axis and the skew parameter value on the horizontal axis, respectively.
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PMC8494202
To improve the prognosis of patients with glioma, many scientists have made unremitting efforts to form the standardized therapeutic principles that have been developed to maximize tumor resection, reduce tumor load, and administer adjuvant radiotherapy and chemotherapy .
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PMC11488203
Fig. S4) and therefore, 0.3 µl lipofectamine/1000 cells was used throughout according to the manufacturers recommendation.
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PMC9926039
Merz-Kollman charges were calculated and nonpolar hydrogens were merged with the adjacent carbon atoms.
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PMC10988555
All solutions were incubated for 24 h at 37 °C and then analyzed.
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PMC11248911
Variable selection was then performed utilizing forward selection (FS) provided in RapidMiner.
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PMC8524093
Other infection routes occur in epidermal and muscle cells.
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PMC11655536
The human MM cell line RPMI-8226 were s.c.
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PMC6337547
For example, the monomer caffeic acid is the basic phenolic acid compound.
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PMC11683130
Silencing of TEAD4 in keratinocytes leads to reduced expression of SerpinB3/4, which suggests TEAD4 can transcriptionally regulate the expression of SerpinB3/4 (76).
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PMC9429973
Despite the cell number reduction, CDK4/CDK6 HSCs displayed an enhanced self-renewal potential during serial BMT.
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PMC10994876
The percentage of cells in the S-phase of the cell cycle is approximately twice as high in OE-YAP5SA cell lines compared to Mock control cells (P-value < 0.0001) (Fig. 6).
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PMC9429973
Aims: We characterized blood and bone marrow samples from the precursor stage, MGUS and from MM patients to determine whether EV content can discriminate between diagnosis and predict patient prognosis.
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PMC9429973
A KRS score has no predictive value in AML; 2.
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PMC11643491
Analysis revealed that the spherical and ellipsoidal particles exhibited ARs of 1.0 ± 0.02 and 1.3 ± 0.14, and roundness values of 0.93 ± 0.02 and 0.78 ± 0.7, respectively (Figure 5B).
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PMC9429973
Further, the abundant CD201 myeloid-bias HSC clusters were characterized by an inflammatory gene signature.
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PMC7553912
The sections were then incubated with Cy2-conjugated or Cy3-conjugated secondary antibodies (Jackson ImmunoResearch) at room temperature for 1 h. The sections were counterstained with 4′, 6-diamino-2-phenylindole (DAPI).
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PMC11045125
EBV+ BLs contain fewer cellular mutations in apoptotic pathways compared to EBV-negative BLs, suggesting that latent EBV infection inhibits Myc-induced apoptosis.
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PMC11092382
However, most of those studies focused only on one aspect, and it is necessary to evaluate whether sophocarpine can exert multifaceted effects on various types of tumors.
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PMC8193813
The O2 analyzer uses a zirconium oxide cell with a measurement range of 0% to 25% and a reported t95 of < 10s.
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PMC7723249
Hence, there were significantly higher levels of IL-6, IL-10 and TNF-α in supernatant from CCHFV infected moDC compared to in supernatant from HAZV infected moDCs (Fig 4).
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PMC11577421
When combining HepIII and Chase, cell uptake decreased by approximately 2.1-fold for NP_BSA and 3.3-fold for NP_BSA+.
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PMC11543885
Polyclonal selection of stable cell line.a.24 h after transfection, change the medium to remove the cell debris.b.48 h after transfection, split the cells to less than 25% confluency in fresh medium containing hygromycin B.Note: In the case of Flp-In T-REx HEK293, the concentration of hygromycin B is 300 μg/mL. For other cell lines, the minimum concentration is to be determined by testing a range of concentrations.c.
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PMC11591794
Our other cell line is the HaCat cell line, which was obtained from Germany (CLS 300493, DKFZ, Heidelberg, Germany).
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PMC11708541
They discovered that 4-AP completely corrected trauma-induced alterations in muscle fibre type composition and greatly improved muscle morphology, cross-sectional area, and minimum ferret diameter from post-injury day 7.
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PMC11463018
Three most sensitive cell lines were RPMI-8226, SR, HS 578 T and NCI-H522 with GI50 values of 0.10 μM, 0.10 μM, 0.14 μM and 0.10 μM, respectively.
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PMC8358176
No data are hitherto available on human cancer owing to exposure to MWCNTs.
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PMC11519077
The adipose sample was minced several times with a PBS solution in order to eliminate blood cells and debris.
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PMC7887261
Notably, in the 15q25.1 region that shows the most significant and consistent genetic signal, a missense p.D398N and a 22-bp deletion (del) in the core promoter region of CHRNA5 have been identified that affect the function and expression.
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PMC9429973
Timely identification of these disorders leads to heightened surveillance for malignancies, specific treatment regimens, donor selection, transplant conditioning regimens, cascade testing in family members and supportive care.
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PMC10482220
Whole-cell extracts prepared from Cos cells transfected with GFP, GFP-G3BP wild type, phosphorylation mutants S149A, S232A, S232E, and BCD-mutant lacking A domain were immunoprecipitated with anti-GFP antibodies.
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PMC11633763
Osteosarcoma cells stably expressing USP22 or shUSP22 were screened using purithromycin (1–5 μg/mL, Sigma).
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PMC6600253
Moreover, elevated expression of p19ARF, p53, and PAI-1is observed in senescent cells serve as senescence biomarkers .
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PMC11530949
Therefore, there is a great interest in investigating controlled drug release, targeted therapy, and decreasing adverse effects associated with anticancer drugs in cancer treatment (6, 7).In this context, the field of nanotechnology, which integrates knowledge from materials science, engineering, chemistry, biology, and medicine has opened up promising avenues in nanomedicine for the diagnosis, prevention, and treatment of cancer (8, 9).
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PMC11607764
PTBP1 can also be used as a potential cancer therapeutic target for inhibiting the growth and metastasis of cancer cells.
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PMC11499381
Statistical significance was accepted when P < 0.05, and is indicated by an * (asterisk).
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PMC9429973
Other causes of death were: 1 ischemic stroke and 5 progression of hematologic malignancies or cancer.
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PMC11476222
CerP, Cer, Hex2cer, GD2, GD3, Hex3Cer, and GD1 were the most abundant, and their percentage relative abundance levels were 28.20 ± 0.91, 16.0 ± 0.9, 13.0 ± 0.6, 10.0 ± 0.2, 9.2 ± 0.2, 7.80 ± 0.05, and 4.8 ± 0.8, respectively.
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PMC11594641
Therefore, targeting the genes driving these processes can support melanoma therapy.
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PMC11615828
Cells possess several distinct MT subtypes that regulate different activities.
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PMC11653533
Mainly, the bark is traditionally utilized in the treatment of diabetes, ulcers, burning sensation, hemorrhages, leprosy, itching, liver disorder, toothache fever, and dysentery (Padal et al., 2013, Nair and Mahesh, 2016;5(5):102.,
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PMC11746948
f Cell death analysis in A375 cells pre-treated with 2-BP and various depalmitoylase inhibitors for 24 h, followed by RSL3 treatment for 48 h, with or without Fer-1.
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PMC11635519
Briefly, when a potential peptide activator stimulates GLP-1R, there is an intracellular boost of cAMP levels.
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PMC8073654
The ethyl acetate extract showed greater activities in this four-assay system compared to those of the petroleum ether and chloroform extracts of the plant.
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PMC11629461
UVA activation of NOX2 results in O2 generation, to subsequently activate the signaling pathway of receptor tyrosine kinase–phospholipase Cγ–inositol 1,4,5‐trisphosphate (IP3)–IP3 receptor (IP3R)–Ca, to trigger persistent Ca oscillation. ,
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PMC9429973
Image: Summary/Conclusion: Our results showed that daratumumab plus bortezomib and dexamethasone had favorable safety and potential advantage among patients with AL amyloidosis presenting severe cardiac involvement.
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PMC11790971
e Plot of the numbers and ratios of cells in artificial pools and monoclonal wells across all passages.
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PMC9429973
Although a rare occurrence dental assessment may identify patients who should not proceed to transplant as planned and in doing so may help to prevent adverse outcome of this intervention.
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PMC11794847
Firstly, sh-NC and sh-HVEM were used to transfect the Jurkat cells.
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PMC10218459
Control cells were treated only with cytostatic agents and incubated for 120 h. The number of live cells was determined after 4, 24, 28, 72, 96, and 120 h using the CASY cell counter and analyzer.
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PMC9429973
In pts with higher-risk MDS, initial response to HMA therapy (7.2 mo in responders vs 2.7 mo in non-responders, p=0.011) and stem cell transplantation at HMA-F (4.7 mo in non-transplanted vs not reached in transplanted, p<0.001) were associated with improved survival.
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PMC11267830
h PCR analysis of THOC1 in J.gamma1 and Jurkat cells treated with indisulam.
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PMC9874064
The cell survival rate of BEL-7404, BEL-7404DPP and A549, A549DPP after 48 ​h treatment with cisplatin, NP-Pt and NP-Pt-USP1i by an MTT assay.
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PMC11700247
CTR, control.
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PMC11194678
All specimens’ statistics in this figure represent the results from three independent batches of experiments are presented as mean ± SD; ns, not significant, *P < 0.05, **P < 0.01, ***P < 0.001 using one-way ANOVA with Tukey’s multiple comparison test.
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PMC11596967
A clonogenic assay was conducted as previously described .
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PMC11723947
Interestingly, while we do not identify a role for HP1β in the crosstalk between Th cell and Treg, we observe that the α and γ isoforms critically and differently regulate Th cell behavior in response to suppressive signals.
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PMC9429973
All other 11 SARS-CoV-2 nucleotide sequences were unique.
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PMC11777207
Crystal structure of the extracellular domain of human PD-L1 interacting with the heavy chain of atezolizumab depicting the amino acid residues in contact.
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PMC11708541
The freshly synthesized s compounds were screened at 50 μM to see if they could bind to JAK2 (Scheme 9 and Table 7).
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PMC11782780
Earlier research has demonstrated the role of miR-301b-3p in promoting cell proliferation and migration in various cancers.
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PMC11394112
The rapid disease progression of VAL-Luc NSG-IL6-xenografted mice relative to the U2932-Luc NSG-IL6-xenografted mice corresponded to a poorer survival (Figure 2A; p = 0.0001; median survival 24 days vs. 49 days).
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PMC11476837
However, we identified K67, RA, and ML-385 as promising candidates for further investigations on the reversal of doxorubicin resistance in leukemia in vivo models and clinical trials.
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PMC11513011
The change over time in the healing area ratio after making the wound is shown, calculated from the healing area divided by the wound area at 0 h. Regarding the KK-47 cell lines, significant differences between the control and DIB treatments were seen with 50nM DIB.
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PMC9429973
OS was also significantly longer following axi-cel infusion than following tisa-cel infusion (1-yr OS 63% versus 49%; HR=1.58, 95% CI, 1.13-2.21; P=0.0072).
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PMC11763111
CAR-T cells were pre-treated with JSH-23 (MCE, HY-13982) for 12 h. 5 × 10CAR-T cells were co-cultured with 5 × 10 CCRF-CEM cells in the presence of CD38 antibody for 30 min.
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PMC11352746
Incorporating these approaches can complement live-cell imaging, especially in the development of training sets for artificial intelligence (AI)-assisted approaches.
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PMC8864075
The invasion-inhibiting ability of reTFAE on A549 cells (n = 3). (
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PMC9429973
Patients with and without adverse events showed similar ETP (1615 vs 1486; P=0.257).
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PMC10813895
Since endocrine-therapy-resistant cells tend to induce ELF5 expression, ER+ cancer cells deriving from ER− luminal epithelial cells progenitors may be predisposed to developing resistance.
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PMC10747160
Spectra were collected at 25 °C on a four-channel 600-MHz Bruker Avance III spectrometer.
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PMC11678368
A2780cis cells were cultured in an RPMI + GLUTAMAX medium (GIBCO) with 10% FBS (HyClone) and 0.3 µg/mL cisplatin (cisplatin 1 mg/mL Concentrate for Solution for Infusion, Accord Healthcare Polska, Pabianice, Poland).
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PMC9429973
Bridging therapy was allowed.
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PMC11012313
Nevertheless, the idea of regulating HIF-1α from the EBV’s point of view makes sense.
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PMC11665555
Gene expression by staging was obtained from R2 (http://r2.amc.nl).
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PMC11753949
Goal of this study was to begin addressing these questions.
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PMC11551844
Ionization was achieved using the electron impact mode at 70 eV. JDH (3.83 mg), JDE (3.36) and JC-2 (3.24 mg) were dissolved in ethyl acetate (1 mL), and then absolute ethanol (3 mL) was added and mixed vigorously using a vortex for complete solubility.
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PMC11661040
KEGG and GO enrichment analyses of the DEGs revealed a significant association between CGREF1 and the wnt signaling pathway, suggesting its potential involvement in β-catenin-mediated molecular functions and biological processes (Fig. 4B, D).
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PMC11721064
To further optimize this process, we focused on differentiating keratinocyte progenitor cells (KPCs) enriched from primary SKCs into corneal epithelial cells rather than utilizing the entire SKCs population.
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PMC11555465
When infected, oocysts break in the gut, releasing sporozoites into the lumen.
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PMC9429973
In the pediatric cohort, for every 10 mmHg increase in PoS, the likelihood of >1 acute complication increased; the aOR was 1.65 (p=0.006).
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PMC11745823
Moreover, oeRIT1 facilitated tumour growth in vivo.
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PMC11367146
Osteoarthritis (OA) is one of the most prevalent degenerative age-related joint diseases, affecting nearly 300 million individuals worldwide .
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PMC11012012
In DLBCL, a sporadic expression of SAP (3/115) was observed .
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PMC9587298
The data showed clearly the formation of both mono- and di-adducts for cyanidin-3-glucoside, cyanidin-3-sambubioside, quercetin-3-glucoside, and quercetin-3-rutinoside.
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PMC8193046
Amongst these multitarget ABCB1, ABCC1, and ABCG2 inhibitors, compound 23 showed promising inhibitory activities against ABCB1 (4.01 µM), ABCC1 (14.8 µM), and ABCG2 (9.27 µM), almost qualifying it as a class 7 compound (Fig. 3).
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PMC11462673
Additionally, flow cytometry revealed that MBZ treatment caused a higher number of cells undergoing apoptosis in positively correlation with the dosage. (
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PMC5941560
But at the turn of the 21st century, some expression irregularities were observed, raising doubts about how closely the cell line paralleled normal human T cells.
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PMC11377827
Quantification of HIF-1α enrichment within the nuclear fraction in HeLa control or following 14-3-3 siRNA-mediated depletion.
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PMC9429973
Median peak C-reactive protein (CRP) value was 20.1 mg/dL, and CRP value greater than 10 mg/dL was present in a median of 4.5 days.
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PMC11705067
Earlier work has reported that the hereditary genetic polymorphisms of ATG5 serves as a prognostic predictor in patients with esophageal squamous cell carcinoma40.
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PMC8097906
1 nM) treatment for 2 days compared to the control (0.1% DMSO).
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PMC8427838
The graph represents three independent experiments ***p < 0.001.
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PMC9351137
RNAi knockdown experiments were performed by transfecting S2 cells with specific siRNAs against each protein (see “Methods”).
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PMC11095939
To this aim, we generated hepatocyte-specific Mecp2 conditional knockout mice (Mecp2-cKO) by crossing control mice containing Loxp sites flanking exons 2 and 3 of the Mecp2 gene (Mecp2) with albumin (Alb)-Cre mice expressing Cre recombinase under the Alb promoter (Figure 2—figure supplement 1A).
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PMC8348645
The leaves of Camellia sinensis, Withania somnifera and the seeds of Vitis vinifera were collected and methanolic extracts were prepared.
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PMC11786156
P < 0.05 The representative results of two separate experiments are shown.
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PMC11547972
A total of 10,000 events were collected for each sample.
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PMC9429973
The study also showed that the Prothrombin Yukuhashi mutation was not prevalent in our cohort.
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PMC10747139
The two Ru(III) and Ru(II) complexes, namely, BOLD-100 and RAPTA-C, are presently being studied in a clinical trial and preclinical studies evaluation, respectively, as anticancer agents.
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