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PMC9000591
Among the tested fractions, SE2 was the most selective fraction in inhibiting KMS11 cells, with an SI of 4.20.
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PMC11742047
Only lipids with q-value < 0.05 and VIP > 1 are shown. (
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PMC11775197
Based on mouse models constructed from the colon cancer cell line CT26 and breast cancer cell line 4T1, the PPARγ agonist rosiglitazone was found to remodel the tumor vasculature system and limit tumor-associated macrophage (TAM) infiltration.
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PMC11401358
CD characterization of (GAGSGA)2. (
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PMC11332076
Immunocytochemical analysis demonstrated AKT phosphorylation in Cos-7 cells expressing myc-tagged F-iIR or F-iIGF1R (arrows).
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PMC11225860
Similarly, this endomitotic DNA replication was not observed with Aurkin A (TPX2/AK-A inhibitor) or alisertib plus Aurkin A combination DLBCL cells.
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PMC6163708
The plates were then fixed in 3% paraformaldehyde solution in 1× PBS and stained with 1% crystal violet and photodocumented.
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PMC11290772
When the NK cells were resuspended and added to the wells or flasks, they displayed a tendency to self-assemble into clustered formations during the subsequent culturing or lysis period.
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PMC9509578
These nanomaterials help to overcome MDR achieved by both efflux pump-mediated and efflux pump-independent mechanisms .
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PMC11754436
The results suggested that, compared with in human osteoblasts, DHRS4-AS1 was significantly downregulated in three OS cell lines.
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PMC11803149
TotalSeq-C0301 (Biolegend, 155861) and TotalSeq-C0302 (Biolegend, 155863) hashtag antibodies were used to stain aged and young cell suspensions, respectively, for 30 min at 4°C.
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PMC11763111
These results highlight the potential of targeting CD38 as a strategy to optimize CAR-T cell therapy outcomes.
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PMC11240571
Anti-PD-1 therapy efficacy in bone and soft tissue sarcomas is controversial.
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PMC11612315
Two-tailed unpaired t test (****p < 0.0001, compared with each control CAP).
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PMC5673955
Enzymatic activity of β‐Gal was elevated at day 15 of cultivation and remained high until day 20 (Fig. 5F).
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PMC11792740
Higher risk of compounded toxicities. -
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PMC10847511
All statistical analyses were performed using Python (3.8.8).
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PMC9429973
Results were expressed as the ratio between values obtained after responding/before treatment with TPO-RA.
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PMC11650848
While methylation varies by site, with CpG4 showing highest levels overall, and CpG5 lowest, it can be seen that the C/C homozygotes tend to have methylation at the lower end of the range, while G/G are at the high end (Fig. 3A).
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PMC9856122
Furthermore, CEP in combination with the 8-difluoromethoxy-1-ethyl-6-fluoro-1,4-dihydro-7-[4-(2-methoxyphenyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic acid (K-12) also reduced viral infection by inhibiting NF-κB and TNF-α in U1 cells .
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PMC11052306
The result of the reaction of the dendrons bearing an alkyne at the core (dendrons 7a,b,c-G1, Figure 10) with graphene oxide functionalized with azides is shown in Figure 11.
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PMC10812665
Modern technologies are required for follow-up strategies linking screen hits to the AOP.
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PMC11496728
An online design website (crispor.tefor.net) was used to design sgRNA targets for the Apaf1 gene.
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PMC11093197
We also evaluated the expression of chromatin licensing and DNA replication factor 1 (CDT1) in cells overexpressing c‐Myc.
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PMC11544122
This hypothesis is supported by the fact that CXCL12-stimulated SNX9 or β-arr1 recruitment to CXCR4 is virtually abolished following over-expression of β-arrestins or SNX9, respectively (Supplementary Fig. S9a–d).
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PMC9429973
No tumor lysis syndrome has occurred to date.
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PMC9429973
E. J. van Beers, H. Al-Samkari, R. F. Grace, W. Barcellini, A. Glenthøj, M. P. Judge, P. A. Kosinski, R. Xu, V. Beynon, B. McGee, J. B. Porter, K. H. M. Kuo Van Creveldkliniek, Department of Internal Medicine, University Medical Center Utrecht, Utrecht, Netherlands; Division of Hematology, Massachusetts General Hospital, Harvard Medical School; Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, Boston, MA, United States of America; Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Haematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Agios Pharmaceuticals, Inc., Cambridge, MA, United States of America; Haematology Department, University College London Hospitals, London, United Kingdom; Division of Hematology, University of Toronto, Toronto, ON, Canada Background: Pyruvate kinase (PK) deficiency is a rare hereditary disease resulting in chronic hemolytic anemia, which is associated with serious complications, including iron overload (FeO).
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PMC11740207
They achieve this through several mechanisms that enable them to bypass cellular aging.
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PMC9429973
Results: As of Nov 1, 2021, enrollment was complete (N=117).
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PMC10565698
We then sequenced the qRT-PCR product of circUSP10 by sanger method and found that the "GA" site was the cyclization site of circUSP10 (Fig. 1C).
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PMC11267036
Trans-well chambers were utilize to evaluate cell migration and invasion.
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PMC11792766
No. CM0067B), d‐glucose (Sigma Aldrich, Cat.
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PMC9429973
The control group (CG) consisted of 200 healthy individuals of the same origin.
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PMC11095939
In response to extrinsic stimuli, such as injury and mitogenic stimulation, the protein levels of Mecp2 are acutely decreased by both transcriptional repression and Nedd4-mediated ubiquitination.
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PMC6889484
An IRDye 800CW-labeled goat anti-rabbit secondary antibody (catalog #926-32211, LI-COR, Lincoln, NE, USA) was used at a 1:10,000 dilution to detect rabbit primary antibodies, and an IRDye 680-labeled goat anti-mouse secondary antibody (catalog #926-68070, LI-COR) was used at a 1:10,000 dilution to detect mouse primary antibodies.
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PMC11496491
The results of GO enrichment analysis in cell components showed that differential genes were most significantly enriched in cytoplasm, intracellular and cytosol terms.
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PMC9429973
Aims: To dissect the role of the Calcineurin/NFAT axis in Bortezomib (BTZ) treatment response and explore the therapeutic potential by combining Bortezomib and Calcineurin/NFAT inhibitors in MM.
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PMC9429973
Methods: We initiate a prospective, single arm, phase II clinical trial.
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PMC10745221
For Fig 3, the 143B-P and 143B-R histones contained 1.6 mg/mL and 2.1 mg/mL, respectively, so 15 μL 143B-P histones and 11 μL 143B-R histones (19 μg) were loaded onto the gel.
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PMC10218459
These CPP-induced apoptosis mechanisms have also been demonstrated for bone cancer cells such as osteosarcoma , Ewing’s sarcoma , and chondrosarcoma The combination treatment with CPP and cytostatics led to varying degrees of activation of apoptosis in the individual bone cancer cell lines.
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PMC9429973
Along the myeloid pathway, CMP can differentiate into either granulocyte-monocyte progenitors (GMP) or megakaryocyte-erythroid progenitors (MEP).
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PMC10758402
All other cell lines used in this study including 786-0 (human renal cell adenocarcinoma), HT29 (human colon carcinoma), 4T1 (mouse breast carcinoma), CT26.wt (mouse colon carcinoma), S-180 (mouse sarcoma), CT2A (mouse glioma), Vero (African Green Monkey Kidney, CCL81).
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PMC11753949
Contractile and non-contractile actin meshworks are known to be implicated in the dynamics of subcellular organelles.
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PMC10604092
The following parameters were calculated: distance travelled: total distance travelled; locomotor activity: number of times the infrared beam sensor responded; and resting time: the total amount of time the infrared beam sensor was unresponsive.
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PMC9429973
Neither extended-spectrum beta-lactamases nor carbapenemase-producing microorganisms were detected (table 2).
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PMC11697189
Then, we compared the differences of 22 immune cells between groups based on the risk score.
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PMC11670407
c Transfected 143B cells were pretreated with 10 μM inhibitor (fer-1, lip-1, nec-1, or Z-VAD-FMK) for 1 h and then treated with cisplatin (10 μM) for 24 h. Cell viability was assayed by CCK8 assays.
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PMC9429973
Aims: The aim of this study was to determine whether NUC-7738 regulates β-catenin and the expression of its target genes in AML cells Methods: AML cell lines KG1a, OCI-AML3, HL-60 and U937 were treated with NUC-7738 for 48 or 72 hours.
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PMC11673128
Dose–response curves were produced using GraphPad Prism 10, and the IC50 value was defined as the concentration of the drug able to inhibit 50% of the vehicle-treated control response (absolute IC50).
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PMC7342409
At imatinib concentrations of 0.05–5 μm, there was no significant effect on the growth of GIST-ir cells (Figure 1A and B).
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PMC8751435
LTD.
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PMC11045125
Thus, our results suggest a model in which LMP1 activates its own transcription in cells with type II latency by enhancing STAT3 activity, and Myc over-expression blocks this effect by reducing expression of STAT3 and Src.
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PMC6024716
Mouse anti-β-actin monoclonal antibodies (Sigma # A2228) and HRP conjugated goat anti-mouse antibodies (KPL # 474–1806, Gaithersburg, MD, USA) were used to detect β-actin in identical samples.
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PMC11532793
Analyses were performed with Salmon and 100 resamples.
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PMC7685376
To explore the targets of Huaier, we then performed proteomics analysis with or without Huaier treatment.
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PMC9429973
O. Shukhov, A. Turkina, E. Lomaia, E. Morozova, A. Petrova, T. Chitanava, Y. Vlasova, E. Chelysheva, E. Kuzmina, I. Nemchenko, A. Bykova, M. Gurianova, A. Kohno, E. Parovichnikova National Medical Research Center for Hematology, Moscow; Almazov National Medical Research Centre; Raisa Gorbacheva Memorial Research Institute of Children’s Oncology, Saint-Petersburg, Russia Background: Asciminib is aa ABL kinase inhibitor that works by Specifically Targeting the ABL Myristoyl Pocket (STAMP) that has shown efficacy and a good safety profile in phase I and III studies in patients with Ph-positive leukemia failing prior TKIs.
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PMC10344560
Leucocyte count of effluent, culture, and antimicrobial treatment.
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PMC10443665
CCRF-CEM and CCERF-CEM/R cells treated with MTX at 0.1 and 0.6 μM, respectively were considered positive controls.
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PMC11695546
Following the incubation procedure, the extra color was again eliminated by rinsing with sterile distilled water a further three times.
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PMC11033180
∗p < 0.05 Mann-Whitney test for each time group.
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PMC6024716
Seven T-25 flasks per cell line were each inoculated with 7 × 10 cells in 5 mL culture media and incubated, as described above.
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PMC11695623
E,F) Effect of down-regulation of DCUN1D5 on cell invasion ability. (
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PMC7504302
FGF9 and its receptors FGFR1 and FGFR3 were found to be upregulated in the nonresponders, in comparison to the responders.
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PMC11742670
In a review by F. Doshi-Velez, various methods are explored, particularly in the context of cancer biology and immunomodulation, to uncover opportunities for repurposing drugs in the treatment of oncologic diseases.
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PMC11748335
Since H3K27me3 tends to localize in areas of low DNA methylation, our findings suggest that studies on the content of oncogenes in BGRDs can be improved after taking account of their genomic localization.
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PMC8751435
Effect of Cordyceps militaris extract (CME) on the viability of A549 cells and observation on cytotoxicity. (
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PMC6642070
Nonetheless, it has been challenged [, , , ], and supplementation of CoQ10 is inconclusive.
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PMC11640476
Top layer: Fibrin gel with cells.
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PMC11676169
All infections of T-ALL cells were performed by spinoculation.
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PMC8740518
Twenty female nude mice were randomly divided into two groups, 10 for the MM CDX model and 10 controls.
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PMC11206251
However, both targeted therapy and immunotherapy have disadvantages.
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PMC10079526
The small molecule inhibitors form irreversible adducts with SUMO in an ATP dependent manner facilitated by the SAE itself.
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PMC11709639
Furthermore, MCUB overexpression mitigated mCa overload, preserved crucial mitochondrial bioenergetic functions including oxidative phosphorylation (OXPHOS) and ATP production, and prevented neuronal cell loss.
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PMC11574271
Moreover, it is noteworthy that the level of RON expression was markedly elevated in cases of invasive bladder cancer compared to non-invasive bladder cancer (Fig. 1A, C).
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PMC10047551
However, the results also show that in the context of NSCLC tumors, the negative correlation between PD-L1 DNA methylation and expression is weak, and this could reflect the fact that, e.g., the IFN-γ-mediated induction of PD-L1 expression does not result in DNA methylation level changes.
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PMC11697065
To investigate cellular adaptations that occur in response to the expression of ETE and DTE biotherapeutics, we generated a panel of monoclonal and bispecific antibodies with differential expression properties.
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PMC6379402
For a given gene and for a given expression threshold, we stratify cancer patients into two subgroups: the group of patients whose expressions of the considered gene in the cancer tissues are lower than or equal to the threshold, and the group of patients whose expressions of the considered gene in the cancer tissues are higher than the threshold.
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PMC11627133
Equilibrium of spirocyclic rhodamine (SpyRho) between the colorless, non‐fluorescent spirocyclic form and the colored, fluorescent quinoid form.
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PMC11786767
To investigate this possibility, we monitored microtubule patterning in cells expressing Ki67-miR, examining whether chromosome collapse and aggregation caused by Ki-67 knockdown were associated with impaired microtubule arrangement.
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PMC11568601
C TGT suppressed the invasion ability of osteosarcoma cells according to the transwell assay.
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PMC11723947
HP1α-deficiency also did not alter the Treg-induced conversion of Tconv into anergic and regulatory T cells (Fig. 2i, j).
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PMC3675084
The inability to overcome drug resistance and inhibit metastasis represents the major cause of treatment failure .
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PMC9895440
As a proof-of-concept, we showed that Snx9 KO improved the antitumor efficacy of adoptively transferred TCR-transgenic T cells and human CAR T cells.
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PMC9429973
The study is planning to enroll 250 patients (220 with MM and 30 with AL amyloidosis).
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PMC11126803
Here, we demonstrate that the LncRNA-SERB can promote ERβ expression by binding to promoter region of LncRNA-SERB and that a high level of ERβ can lead to the formation of VM through transcriptional regulation of ZEB1.
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PMC4685341
For this purpose a method was established in collaboration with Roche Diagnostics to quantify the gene expression level of the glycosylation enzymes using RT-qPCR based on the RealTime ready technology.
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PMC11286266
Both the association and dissociation phases were fitted to a single exponential association-dissociation model, yielding a KD within the range of 1 µM, a concentration that was consisted with the estimated CRT concentration in the ER of CHO-K1 cells obtained through quantitative immunoblotting (~7 µM) (Figure 4—figure supplement 1).
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PMC4369959
Terpene components of ginger include zingiberene, β-bisabolene, α-farnesene, β-sesquiphellandrene, and α-curcumene, while phenolic compounds include gingerol, paradols, and shogaol (Figure 2).
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PMC9429973
Methods: We have performed the karyotype staining the chromosomes by G-banding and the results were reported according to the International System for Human Cytogenetic Nomenclature (ISCN, 2020).
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PMC10587429
We isolated hCD34 HSCs from fresh cord blood units and found that the recovery rate of CD34 HSCs was around 1% of the number of mononuclear cells ( Figure 2A ).
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PMC11779605
Gene symbols from the dataset were mapped to this reference package, and associated pathways were generated using the clusterProfiler package gseGO function.
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PMC11731161
Alexa Fluor® 488 Goat Anti-Rabbit IgG H&L (ab150077) was purchased from Abcam.
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PMC11747467
A lower gDS indicates that the gene is more important for cell viability.
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PMC9429973
Image: Summary/Conclusion: Using fresh CSF sample with lyse-no wash protocol enabled us to detect approximately 10x higher blast count (0.24ev/µL in FC+CNS1 and 1.25ev/µL in FC+CNS2/3) than was recently published (0.015ev/µL in FC+CNS1 and 0.073ev/µL in FC+CNS2/3 in Thastrup et al., 2020), and thus it better correlates to cytomorphological data.
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PMC10291556
Samples were analyzed by flow cytometer BD FACS Verse.
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PMC3765139
Results are shown in Table 1.
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PMC11750696
The intricate interplay among IRE1, PERK, and ATF6 involves multiple layers of regulation, allowing these proteins to respond to immediate cellular demands during ER stress and to modulate long-term adaptations that enable the cell to manage chronic stress.
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PMC11700247
Activation of STING pathway in A20 tumors treated with CART-19 alone or combination of CART-19 and RT.
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PMC11127909
After cells grew in medium with 0.5 µg/ml cisplatin, they were designated as cisplatin-less sensitive cell line and termed 143BR.
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PMC9429973
NOD/SCID mice receiving CD9+ AML exhibited a drastic reduction of leukemic load by 70.7-91.8%.
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