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PMC10919056
Differential analysis of clinicopathological parameters between the high-RS subgroup and the low-RS subgroup.
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PMC11774112
After preparation, the product was lyophilized.
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PMC10698968
In this work, we present a novel spontaneously immortalised MFS-patient-derived cell line, named MF-R 3, that recapitulates in 2D and 3D clinically relevant features of the original tumour.
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PMC9621239
Three dimensional structures of wild-type HBx, mutant HBx and MYC are displayed respectively at the top of the panel.
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PMC11697703
However, in neurons expressing both miR-193b and -365, there was a significant increase in spine density in basal and apical dendrites compared to scrambled controls (Figures 5B and 5D).
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PMC11381192
Kaplan–Meier curves showed that the OS outcomes of high‐risk patients were significantly inferior to those of low‐risk patients within five stress models (all p < 0.001, Figure 1B–F).
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PMC10759659
The immune infiltration level was estimated by single-sample GSEA using the Gene Set Variation Analysis (GSVA) program against the gene signatures representing immune cell populations (Supplementary file S2).
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PMC11707832
Implication of MAN2B1 in diverse diseases AD, alzheimer′s disease; BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; COAD, colon adenocarcinoma; DLB, dementia with Lewy body; FTD, frontotemporal dementia; Mut, mutation; NA, not attention; SLE, systemic lupus erythematosus.
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PMC5173112
Hence, these two lines were chosen for the functional characterization of USP21. (
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PMC10565698
B. Database-dependent prediction of miRNAs that can bind to circUSP10.
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PMC11411131
Chemiluminescence images were acquired using a ChemiDoc Touch system (Bio-Rad Laboratories, Hercules, California, United States of America).
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PMC11684269
cannot be excluded (141).
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PMC11247842
Similar to the meta-analysis for CM, we observed an increase in the number detected QTL by using MR-MEGA (Fig. 2b) compared to METAL (see Additional file 2: Figure S5) for SCS.
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PMC11655498
CRISPRi and CRISPRa can also be employed to modulate non-coding RNAs (ncRNAs).
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PMC11506827
Research has highlighted the potential therapeutic effects of various natural products against RCC.
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PMC11634794
Moreover, patients with lower LAMP1 expression exhibited worse prognosis.
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PMC9964635
Upon completion, the reaction was acidified to pH 4–5 with conc.
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PMC11763126
KEGG analysis indicated that these peptides could play roles in cancer-related pathways such as necroptosis and viral carcinogenesis (Fig. 1D).
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PMC10761571
Mohammad Rezaei: Resources.
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PMC9429973
Nanobody technology open new avenues in the detection capability of MRD flow cytometry studies in the era of immunotherapy.
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PMC4816271
The phenomenon of lower MFI at day 7 compared with Day 3 is observed equally in vectors containing or not containing the C to S mutation suggesting that non-specific activation of the suicide gene is not responsible for this silencing.
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PMC7192625
Thus FitHiC returns a P-value for each detected contact.
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PMC7022782
In cells treated with both unloaded and ICG-loaded NPs, specific relationships between coated vesicles and a particularly extended cytoplasmic membrane system suggested a complex dynamic mechanism, where endoplasmic reticulum and Golgi apparatus are realistically involved.
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PMC7351993
Since the differentiation and lipogenesis of adipocytes are a highly heterogeneous process, enrichment of adipocytes with unique spatial features (e.g., spatial distribution or localization of cytoplasmic lipid droplets, cell area, total lipid amount) is required for detailed analysis of the cells.
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PMC11770199
This analysis revealed activation of inflammatory pathways and regulation of the transcription levels of caspase family members.(Fig.
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PMC11583010
Total antibody concentration decreased steadily from 170 to 18 μg/mL at day 21 (504 hours) in tumor-free control mice (Fig. 4A).
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PMC8481254
As expected, no change in the proliferation ability of cells cultured in l-glucose was observed (Supplementary Fig. 3B–D).
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PMC11634794
LAMP1 is a promising target for the treatment of ccRCC.Renal cell carcinoma (RCC) is a highly prevalent neoplasm of the urinary system, exhibiting an escalating global incidence and mortality rate (1).
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PMC9429973
The median duration of defibrotide treatment was 15.0 (range: 3, 55) days.
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PMC11726848
No statistically significant differences were observed after HDR irradiation (Figure 5D).
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PMC11519583
Right graph shows proportion of cells with blebbed nuclear membrane (n = 3).
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PMC11727638
Lymphoma is a type of blood cancer classified into two types: Hodgkin lymphoma and non-Hodgkin lymphoma.
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PMC5854676
Beside this aforementioned process, there are many synthesis techniques that researchers have applied in different semiconductor devices and in studies on thermoelectric properties.
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PMC9429973
V. Egor, A. Yuliya, K. Brenning, A. Itov, D. Abramov, A. Sharlai, M. Senchenko, D. Konovalov, G. Novichkova, N. Miakova Oncohematology; Pathology, Dmitry Rogachev National Medical Research Center Of Pediatric Hematology, Oncology and Immunology, Moscow, Russia Background: Reduced-intensity rituximab-based therapy leads to long-term remission in more than 80-85% of pediatric patients with B-cell non-Hodgkin lymphoma (B-NHL), but in case of relapse or refractoriness the prognosis in poor with less then 20% survival rate.
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PMC9844987
This indicates that additional information influencing variability may be encoded within the promoter sequence.
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PMC11779960
a Median frequency of the top 2 TCRβ clonotypes in AITL, CTCL, PTCL and TPLL cohorts (Thiele et al., Liu et al., Suma et al. ).
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PMC10671321
As shown in Figure 2, both the WT and mutated cDNAs were transcribed and translated in COS cells (Figure 2A) and muscle cells (Figure 2B), although at different levels depending on the cell system used for expression.
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PMC11644761
These characteristics, coupled with reduced toxicity relative to other stilbenoids, make pterostilbene a promising drug candidate for various pathological conditions .
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PMC11752767
The latter acts by inducing apoptosis in cancer cells or virus-infected cells via the expression of FasL (ligand of Fas receptor, or CD95, tumor necrosis factor receptor superfamily member 6) or TRAIL (TNF-related apoptosis-inducing ligand) molecules on their surface.
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PMC9341513
ChIP-seq data for CTCF is used to identify direction-dependent anchor sites for loop extrusion.
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PMC8839885
Briefly, cells were plated at 5 × 10 cells/mL, and on the following day the compound RJY13 (5 μM) was added for 6 h. Cells were collected, washed four times with cold PBS and re-suspended in dH2O.
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PMC11499381
The resulting DNA was sequence verified by Sanger sequencing (performed by the DNA sequencing facility at the Centre for Genomics, Proteomics, and Metabolomics at the University of Auckland School of Biological Sciences).
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PMC9429973
Image: Summary/Conclusion: Zanubrutinib may be a viable therapeutic option for pts who are intolerant to acalabrutinib—80% of pts received clinical benefit, and most did not experience recurrence of their prior intolerance events.
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PMC11361748
Sections of WT and Krt17 mouse skin 6 h after double TPA Tx, 24 h apart, were immuno-stained for phospho-PKCα (T638), K14, and nuclei (DAPI).
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PMC9429973
Patients who relapse from or are refractory to 1 line therapy face dismal prognosis.
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PMC5261804
Thus, combinations of computational and experimental methods will be critical to enable identification of the most promising PPIs that are essential to the survival of cancer cells.
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PMC11782508
SDS-PAGE of azurin fractions.
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PMC11648299
In these analyses, individuals with use of immunosuppressive drugs and/or retinoids were excluded from the HR analyses.
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PMC6160470
Moreover, the results uncover the importance of side-chain length, whereby the compound with two carbon atoms in the linkage has the best inhibitory activity (i.e. DAC-2Amide).
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PMC10530622
For instance, a pilot study involving CaOx stones formers and healthy subjects reported higher levels of IL-6 in stones formers .
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PMC11746942
The shaved skin on the back was selected as the injection area.
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PMC11544122
Endocytosis was calculated as a fractional decrease in cell surface receptors in CXCL12-treated cells compared with vehicle-treated cells after background subtraction, which was assessed in parallel using an isotype control antibody.
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PMC11775197
The objective is to develop novel PPAR agonists and antagonists for more stable and practical application in clinical settings.
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PMC9596868
E-F) Isobologram analysis and CI versus FA plot for the eight drug combinations of quercetin and MST-312 in OVCAR3 cells.
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PMC11632064
PLK1-targeting approaches included gene knockout by CRISPR/Cas9, gene silencing by RNA interference, and PLK1 inhibitors: BI 6727, BI 2536, GSK-461364, HMN-214, NMS-1286937, and GW-843682X (Fig 7A).
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PMC8358176
The expression levels of TNFRSF11B and TNFRSF1A did not differ meaningfully between the groups (p = 0.091 and p = 0.128, respectively).
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PMC11592837
The results, shown in Figure 1, demonstrate a dose-dependent increase in the proportion of fluorescence-positive cells with ETP-concentration, with a significant difference (p < 0.05) of the mean value over DMSO controls starting at 5 µM ETP.
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PMC11599565
Trypsin treatment was neutralized using DMEM containing 10% FCS and again centrifuged at 500×g for 10 min.
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PMC11387401
NC nucleocapsid, MA matrix, IN integrase, PR protease, CA capsid.
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PMC11568601
Meanwhile, TGT dramatically upregulated the expression levels of cleaved caspase-3 and cleaved PARP1 in osteosarcoma 143B cells (Fig. 5B).
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PMC11545737
In THP-1 cells secretion of IL-1β is also induced by N. cinerea and N. flavescens but these commensal species are weak inductors compared to N. gonorrhoeae .
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PMC8806312
Mutations in prognosis-related IRGs A PI was developed based on MCR analytical results.
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PMC9429973
In a unifactorial analysis, for all MDS patients progression to AML was significantly associated with mutations in the RUNX1 (p=0.001) and SRSF2 (p=0.0026) genes.
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PMC11334037
P < 0.05; P < 0.01; P < 0.001.
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PMC11762280
P < 0.001.
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PMC9429973
Our findings reinforce that triage decisions solely based on the age or type of HO disease are not justified, but instead should be based on a multidisciplinary approach with intensivists and experienced hemato-oncologists.
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PMC11381192
Differential expression was observed in UBE2T, RNF121, UBE2G2, ANXA2, ENO1 and ALDH2 between C1 and C2 subtypes (Figure 8A).
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PMC11720107
Briefly, the cells were incubated with increasing concentrations of garlic cultivar extracts for 6, 24, or 48 h. The medium was then replaced with fresh medium containing 10% resazurin and 1% FBS.
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PMC11541241
Plant diseases caused by fungal pathogens directly cause huge losses in the yield of staple crops and economically important commodity crops.
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PMC11766350
The particular miRNA was chosen due to it being highly expressed in HEK293 cells, thus silencing the transgene mRNA during rAAV production, but not in the patient target tissue .
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PMC11748335
Given that (i) common PMDs and common HMDs exhibit distinct DNA methylation profiles, (ii) the significant impact of DNA methylation on the distribution of H3K27me3, we conducted independent analyses on long LOCKs within these regions.
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PMC11489351
The background was subtracted using the straight-line tool, and the area under the enclosed curve was determined.
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PMC9684669
To determine if blocking CREB1 would similarly resensitize MDR cells to doxorubicin, A2780-ADR cells were treated with the selective CREB1 inhibitor 3i (also known as 666-15 (44).
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PMC11680391
Effective communication will only become more important because even though automation and the increased application of milking robots and sensor technology will remove the need to align with some operational staff, clear communication and establishing specific and realistic goals with the dairy farmer is still essential.
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PMC9503669
Nevertheless, this study provides additional support for the development of Nef antagonists that reverse MHC-I downregulation as part of a strategy to boost the host immune response to clear HIV-infected cells.
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PMC7823217
These cell models can be overall divided into: (i) co-culture systems, (ii) multicellular spheroids, and (iii) cells loaded or cultured in an ECM mimetic biopolymeric scaffold (Fig. 1).
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PMC11461874
Similar results were obtained by monitoring decay of bioluminescence signals derived from DBP-Luciferase (DBP-LUC) fusion protein (Fig. 1b).
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PMC8992508
By the comparison between activity and calculated logP values a tendency of higher activity with greater lipophilicity was observed.
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PMC11306019
For instance, Figure 2 demonstrates that 1.56 μM PGG is needed to counteract 12.5 nM BTZ, and only 0.78 μM PGG is required for 6.25 nM BTZ.
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PMC11291490
Data were presented as means ± s.d. (
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PMC11742231
Finally, an attention mechanism is applied and fully connected layer as follows:15[12pt] $$ e_ = ( }^T [ } }_i } }_j ] ) $$=LeakyReLUaTWhi‖Whjwhere represents the attention score between node i and node j, is the weight vector, is the weight matrix, and are the feature vectors of nodes i and j, and denotes concatenation.
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PMC11476004
Heaton et al. used the comet assay to identify oxidative damage in the leukocytes of healthy dogs.
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PMC10969097
Cancer cells develop characteristics known as “hallmarks of cancer” which contribute to the growth and progression of tumours.
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PMC3765139
Surprisingly, the expression of CD133 on WM115 cells was not detectable under the conditions used in this study.
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PMC11637284
All cell lines derive from a single marker T. brucei 427 cell line grown at 27°C in SDM-79 supplemented with 5% (v/v) fetal calf serum.
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PMC11773391
Although related studies have assessed the molecular mechanism regulating MGMT in glioblastoma, the signal transduction pathway regulating MGMT in melanoma cells has not been elucidated.
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PMC11731161
C Quantitative analysis of tumor volume in the different groups.
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PMC5025404
Therefore, a tedious and labor-intensive effort for DHFR-mediated gene amplification is required to obtain recombinant CHO (rCHO) cell clones with a high expression level of the target gene.
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PMC9429973
Downregulation of BCL11A is mechanistically distinct from the current standard of care, Hydroxyurea, and pre-clinical HbF induction via FTX-6058 exceeds that observed with Hydroxyurea.
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PMC8526701
The scale used to assess the staining intensity was negative (0), weak (1), moderate (2), and strong (3).
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PMC11721587
The cells were subjected to centrifugation, and the pellet was resuspended in cold Farnham lysis buffer.
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PMC11371747
Alternatively, in order to study side effects of MTX, adequate in vitro models such as a clonogenic assay for bone marrow toxicity (Jolivet et al., 1994) can be used.
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PMC9111184
Although the presence of hydroxycinnamic acid derivatives decreased cholesterol permeation, the treatment with EZ showed the most important decrease in cholesterol permeability and it was statistically different from m-CA; ChA and RA at a critic level of 5%.
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PMC11575040
Among these, four cell lines, A375, A2058, RPMI 795, and RPMI 7951, carry the BRAF V600E mutation, while the MeWo cell line possesses the wild-type BRAF gene.
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PMC11543853
Membranes of a sub-population of endosomes in non-infected cells were also warped, indicating that this is a natural cellular process (Fig. 3a, Supplementary Fig. 7, Supplementary Table 1).
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PMC9429973
Acknowledgements: This work was partially supported by a GACR grant 22-18300S and institutional funding from the IMG CAS (RVO 68378050).
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PMC11468365
This process is repeated across parallel attention heads, and the resulting vectors from each head are concatenated to produce the final vector, as described in Eq. (8).
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PMC11766332
To evaluate the simultaneous involvement of multiple ASD-miRNAs acting to tune one individual glycosylation pathway and to identify their target genes, we extended the set of miRNAs (N = 25), performing extra functional analysis through the reconstruction of their regulatory networks.
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PMC10728200
The results are displayed as a ratio of oxidized/reduced C11-BODIPY.
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PMC9429973
T-LBCL develops in an immune privileged site behind the blood-testis barrier and has a molecular profile similar to primary central nervous system lymphoma (PCNSL).
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