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PMC7039683
This network model raises additional testable hypotheses, including that GRHL transcription factors regulate expression of the other transcription factors enriched in periderm.
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PMC11588085
We investigated whether a transition from M-CSC to E-CSC occurs in ovarian cancer cells under hypoxia.
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PMC9516447
Total RNA was extracted and subjected to reverse transcription and real-time PCR to measure the mRNA levels of GRP78 and KRAS with GAPDH serving as control.
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PMC11352877
To analyze angiogenic properties based on in vitro cell migration, a wound healing assay (Figure 6) was performed on the control cell line with normal angiogenesis, HME1; the ectopic endometriosis cell line, 12Z; endometrioid adenocarcinoma, A2780; and malignant tumor cells of uterine endometrium, RL-95-2 and SK-UT-1.
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PMC9429973
Analysis of the primary endpoint (GRFS) will take place after 86 events are known to have occurred.
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PMC11634027
The D motif also associates with other factors important to Ds-Fat signaling, including Dachs, Sple, Fat and MyoID (Myo31DF), and by making smaller deletions of the D motif the effects of Lft could be partially separated from other requirements for this motif.
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PMC6642070
Mitochondrial dysfunction is the most privileged hypotheses of SAMS.
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PMC9429973
RAS/MAPK mutations appear to drive both primary and secondary resistance.
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PMC11672881
ZP4 also appears to play a role in immune modulation.
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PMC11548041
The predicted interacting residues differed between the EpEX monomer and homodimer, emphasizing the importance of performing the simulations with both.
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PMC9454178
The results showed that OSR1 was uniquely overexpressed in GIST and prostate cancer compared with other cancer types.
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PMC9895440
f Percentage of SNX9+ cells among CD8 T cells for each sample before treatment with ICI.
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PMC11155445
All derivatives inhibited AChE and BChE much better than standard Tacrine (TAC), except compound (8e).
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PMC11519077
Inflammatory bowel disease (IBD), as a set of illnesses characterized by a complex and multifaceted disease, is linked to genetics, environment, intestinal microbes, and mucosal immune responses that are out of balance [1–4].
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PMC11678448
A correlation coefficient analysis was performed on the central genes (Figure 7C).
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PMC11089031
To validate the KM survival analysis results, we performed receiver operating characteristic (ROC) analysis using the “survival” package in R. As shown in Fig. 1C, the AUC was 0.675 with 1< 0.05, suggesting that ZNF692 may be a possible prognostic factor.
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PMC11001582
Tissues were dissected and flash-frozen.
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PMC9429973
Aims: To explored the risk factors of GI bleeding and the efficacy of CAR-T cell therapy for GI lymphoma.
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PMC11683130
Clade E (3 members) are located on chromosome 2, 7 and 13.
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PMC9325715
The d–d transitions result in a weak absorption band.
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PMC11365983
Cells overexpressing Foxc1 exhibit increased basal levels of Gli1, Gli2 and Ptch1 mRNA (n = 3). (
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PMC11680049
The results show a significant presence of secondary metabolites in the conducting tissues of the Sequoia stem, particularly within the cell walls of the xylem vessels and the phloem.
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PMC11714165
Schematic diagram of the experimental procedure.
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PMC11502962
We aimed to discover the infiltration cell types and the relationship between the infiltrating-immune cells and the progression of GIST.
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PMC11365983
The Foxc1 embryos carrying the null Foxc1 mutation were generated and genotyped as previously described.
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PMC11655498
BGLF4, an EBV-encoded protein kinase, not only activates the expression of BGLF3, but together they control post-replication processes and regulate the expression of late genes (El-Guindy et al., 2014).
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PMC11401350
BM was then put in culture for 5 days to allow differentiation in bone marrow derived macrophages (BMDM) in RPMI GLUTAMAX medium (Life Technology) supplemented with 10% FCS, 50 μg/ml of penicillin/streptomycin (Invitrogen, Fisher scientific—Illkirch, France), gentamycin (Thermofisher, 15,750–045) and murine M-CSF (macrophage colony stimulating factor; Miltenyi, 130–101-704).
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PMC10578720
To verify the effect of SIRT3 downregulation induced by HBV on macrophage phenotype, human THP-1 macrophages were infected with a control lentivirus (vector) or lentivirus (Flag-SIRT3) to overexpress SIRT3 (Supplemental Figure S4A, http://links.lww.com/HC9/A586).
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PMC11772585
n = 5. **
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PMC8557138
However, in pathological conditions, studies have shown reprogramming of endothelial cell metabolism due to (epi)genetic changes and also as a consequence of continuous interactions with other cell types.
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PMC9429973
In addition we are complementing this transcriptional profiling with functional metabolic assays.
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PMC11770199
These findings indicated a direct and potent cell-killing effect of cell–cell fusion, which was sufficient to kill cancer cells, even without the cytopathic effect of the oncolytic virus.
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PMC11472639
Additionally, our in vitro assay showed an increase in daratumumab-mediated ADCC activity when PBMCs isolated from participants were incubated with RPMI-8226 plasmacytoma cells, which was then nullified in the presence of antibodies blocking CD16 and CD32 receptors.
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PMC7757104
Similar to ACRP cells in which OPNc was silenced, A2780 OPNc cells were also more sensitive to CDDP treatment compared with the control cells.
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PMC11774251
Representative histograms of PI staining for cell cycle analysis. (
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PMC9429973
Despite the acceptable results concerning remission rate but survival rates remain lower than those observed in the literature, this is explained mainly by the high rate of relapse (29% vs ≃15%).
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PMC11673902
One of its major advantages over other methods of studying cell mechanics is that it is simple and straightforward to operate, but it suffers from the problems of bulky equipment and low throughput.
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PMC10291556
Digital images were taken by the QuickPHOTO MICRO 3.1 program (PROMICRA, Prague, Czech Republic) and processed with the TScratch analysis software (ETH Zürich, Switzerland).
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PMC11806182
Multiple testing corrections were applied where appropriate, using methods such as the Benjamini–Hochberg false discovery rate.
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PMC9429973
The frequency of known patients with high-risk mutations in RUNX1, ASXL1, and TP53 was similar for both treatment groups.
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PMC9429973
T. De Vos, T. Putteman, M. Lavaert, A. Kuchmiy, J. Philippé, T. Taghon Diagnostic sciences, UGent, Gent, Belgium; Laboratory of genome integrity, National cancer institute, Bethesda, United States of America; eTheRNA Immunotherapies NV, Niel, Belgium Background: The Notch signaling pathway is an important regulator of normal hematopoiesis and is often involved in leukemia.
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PMC10812665
levels were at >200% of normal.
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PMC11806106
However, the main problem was the membrane expression of these MOR-based constructs.
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PMC10142392
The micelles were loaded with Paclitaxel (PTX), an anticancer drug.
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PMC6133382
Many of these recognize epitopes consisting of both amino acid and glycan residues.
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PMC11597291
The release profile of PCT from the nCGO-PEG/PCT particles was obtained under sink conditions in 1xPBS buffer pH 7.4 and 6.0.
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PMC11413393
1An epigenetic chemical probe screen identifies type I PRMT inhibitor MS023 as an inhibitor of ccRCC cell proliferation.a Heat map showing the average cell proliferation values in the presence of the indicated epigenetic chemical probe after seven days exposure in eight ccRCC cell lines (data shown as mean of n = 3 technical replicates).
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PMC11765243
Furthermore, whereas both p110α-(A66) and p110δ-specific (IC87114) PI3K inhibitors inhibited the elongation of Tfh from WT cells, only a p110δ-specific PI3K inhibitor inhibited p110αKD-T Tfh cell elongation, confirming the specificity of the effect (Figure 7B).
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PMC10079526
Upon 5-Aza-2’and TAK981 treatment, DNMT1 remains entrapped at the DNA.
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PMC11739504
TTBK2 is a ciliary gene that is involved in the early stages of ciliogenesis.
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PMC11392912
Further, the stability of Clo-miR-14 at cooking temperature was checked by incubating clo-mir-14 at several time points (0, 20, 30, 40, 50, and 60 min) at 100°C (Figure 2C), running PCR product on 1% agarose gel, and by analyzing PCR product (Figure 2D).
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PMC11750165
Primary antibodies used were as follows: anti-Myc antibody (Sigma-Aldrich, St. Louis, MO, USA), anti-Flag M2 antibody (Sigma-Aldrich) and zn5/DM-GRASP antibody (Developmental Studies Hybridoma Bank, Iowa City, IA, USA).
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PMC9429973
While graft versus host disease and relapse-free survival (GRFS) is used as a favorable composite outcome after alloSCT, a widely accepted measurement for treatment success after IST is missing.
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PMC11754291
As a result, despite the inherent limitations of in vitro research, our findings provide a robust foundation for understanding melanogenic responses to blue light.
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PMC11407042
Note: The absorbance should be read within 1 h after adding the stop solution.
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PMC9065483
Densitometry following western blotting uncovered that the phosphorylation ratios of EGFR and the downstream extracellular signal-regulated kinase 1/2 (ERK1/2) were increased with vanadate and VSVΔ51 combinational treatment compared with all other conditions (Figures 1D and S3).
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PMC11129910
Our results show that the cooccurrence of the loss of RAB25 and the expression of mutant H-RAS61L is necessary for cells to transform.
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PMC11770130
The DESeq2 R package (25) was finally used as an expression analysis tool to analyze the differences between the two groups.
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PMC5839394
Moreover, it has been documented that autophagy may act as enabler of apoptosis, contributing in certain morphological and cellular events that take place in apoptotic cell death .
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PMC10114490
Preprocessing of data for untargeted analyte profile including peak detection, deconvolution, alignment and integration was performed by XCMS v 3.4.2 software in R v 3.5.0.
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PMC11699465
CD274, also commonly referred to as programmed death ligand 1 (PD-L1) is an essential immune checkpoint protein.
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PMC5716223
Moreover, we confirmed that NGF promotes myogenic fusion and expression of the structural protein myosin heavy chain while modulating NFκB activation and the content of sHSPs correlated with the differentiation process.
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PMC9268620
Damnacanthal and nordamnacanthal (Figure 1) are two naturally occurring anthraquinones present in M. elliptica that have been reported to possess good anticancer properties.
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PMC9621239
Further, the transactivation activity of wild-type HBx could play a negative regulatory role on cell transformation; however, on the alteration of the aa residues of HBx protein, such as COOH-terminal truncation, HBx could exhibit a proliferation-promoting effect.
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PMC9429973
Dose reduction may be required for some patients to improve tolerability.
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PMC9429973
Bone pain was the most common presenting complaint observed in 65% of the cases.
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PMC10818573
Mammalian cell lines, such as Chinese hamster ovary cells, hybridoma cells, human embryonic kidney cells, and young hamster kidney cells, are commonly used for the development of antibodies and other drugs .
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PMC9454852
Cells were plated in a 96-well plate, allowed to attach overnight, and then loaded with DHR-123 (30 µM) in a loading buffer, at room temperature in the dark over 30 min .
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PMC2614415
We sought to establish gene expression profiles of ovarian cancer patients in order to determine genes whose expression was significantly different between carcinoma, adenoma and tumors pretreated with chemotherapy.
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PMC11359735
Lower panels show representative images of CSP-stained sporozoites and their associated trails.
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PMC9454852
In order to determine if ER is the source of calcium observed into the cytosol during [Ca]i variation due to BOLD-100 treatment, the time-lapse observation for BOLD-100 treatment was thus repeated after 30 min of pretreatment with 5 µM thapsigargin, a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca ATPase (SERCA) .
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PMC11397654
It could be argued that although the N-acyl-proline derivatives are active against cancer cells, their cytotoxicity may hinder their usage as selective drugs in antitumour therapy.
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PMC9429973
Two versions of a questionnaire were developed: one for adult patients and another for caregivers providing unpaid care to a patient.
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PMC9429973
However, even in the presence of the maximum dose of anti-CD44 (5µg/mL)), 46% of KG1a and 48% of OCI-AML3 cells remained persistently adhered.
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PMC11519567
These results indicate that the formation of SS18-SSX condensates depends on the binding of the acidic region of C-SSX to the widely distributed histone modification H2AK119ub.
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PMC11402217
Most strikingly, XD23 treatment yielded pronounced cortical bone thickening and structural reinforcement, suggesting a role for the compound in halting OS growth and reducing bone loss.
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PMC11761919
PBLs cultured with RPMI1640 medium alone served as controls.
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PMC9429973
HbSS/HbSβ genotype was present in 54.3% (n = 70) of the patients and HbSC/HbSβ genotype was present in 45.7% (n = 59).
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PMC10747139
The suppression of Grp78 transcription is a mechanism described for antiviral activity, which has also been demonstrated against SARS-CoV-2 .
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PMC8978939
Total RNA from the different cell lines was extracted with Direct-Zol RNA Kit (Zymo Research, Irvine, CA, USA) following manufacturer’s protocol.
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PMC9096373
The mean tumor volumes (TVs) were calculated using TVs = dmax × dmin/2 and TGIR was calculated using TGIR (%) = (Reference Group TVs – Experimental Group TVs)/Reference Group TVs × 100%.
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PMC11063646
The spreadability of an emulgel is crucial for its application.
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PMC8864075
Relative expression of target protein = target protein band/β-Actin band.
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PMC9429973
Serious infections were reported in 7 (31.8%) pts, including one pt with sepsis due to streptococcus pneumoniae.
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PMC10495912
Then, 100 µl of dimethyl sulfoxide (DMSO) solvent was added to each well to dissolve the formazan crystals, and the absorbance changes were read at a wavelength of 570 nm using a microplate reader (Synergy HTX, Biotek, USA).
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PMC9454178
Subsequently, studies indicated that the SE domain was essential for c-KIT gene expression and tumorigenesis, including FOXF1, HAND1 and BARX1 .
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PMC9429973
By this research, we can get closer to understanding, recognizing and treating diseases as a result of immunodeficiency.
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PMC9429973
Median time on Ven was 27.4 (range, 0–79.3) mo.
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PMC11687167
③ NF-κB signaling pathway.
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PMC9429973
22% were refractory to a proteosomal inhibitor, 68% to an ImiD and and 5% to an anti-CD38 antibody.
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PMC9622879
Another research direction is to develop a cooperative strategy for many communities, whereby a community can buy or sell energy from another community.
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PMC9429973
Previously reported ORR with hypomethylating agents such as azacitidine alone is less than 30%.
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PMC11539788
54 Paired BCa samples and adjacent normal tissues were collected from Renmin Hospital of Wuhan University.
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PMC9429973
Aims: The purpose of this study was to investigate the association between DR and outcome in overweight patients with AML.
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PMC11502327
Yan et al. (40) demonstrated that Baicalein can inhibit the expression of matrix metalloproteinases (MMPs) in OC cells and significantly inhibit the invasion of OC cells.
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PMC11746948
Through ischemia-reperfusion experiments, we elucidated the protective role of GPX4 palmitoylation-mediated resistance to ferroptosis, with the APT2 inhibitor ML349 significantly reducing liver injury caused by ischemia-reperfusion.
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PMC11547917
The low phenol content suggests that other molecules with a different polarity, likely generated by hydrolysis, and other cleavage events may be responsible for the high antioxidant effect that has been experimentally obtained.
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PMC6600253
These two chaperone proteins are involved in the assembly of the catalytic domains of telomerase on their RNA templates.
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PMC11680982
To confirm RNA stability, the RNA decay test was performed with actinomycin D (ActD) (MCE, USA, HY-1559).
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PMC11789597
The integral membrane protein caveolin‐1 (CAV‐1) is a primary component of lipid rafts and mediates cellular processes dependent on lipid raft structures.
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