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OTAR3088
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BioData-CellLine_annotated

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PMC11271278
For HiChIP data from NCIH2170 cells with and without CRISPRi-mediated MYC promoter repression, we presented and compared their virtual 4C signal anchored at MYC or ERBB2 promoters.
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PMC11243198
In contrast, high concentrations of GANT61 did appear to be cytotoxic for these cells.
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PMC10748106
This electron density pattern is observed in Artselaenin A, which was the most similar to D9, D35, and D56 (Figure S8A,C,F).
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PMC8557138
DelNero et al. constructed an alginate-based 3D vascularized tumor model capable of maintaining a homogenous oxygen level.
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PMC9065483
Given this homeostasis, vanadium maintains the phosphorylated state of multiple cellular substrates, typically resulting in the persistent activation of their downstream signal transduction pathways.
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PMC9429973
A. Ben Hamza, C. Welters, M. Brüggemann, K. Dietze, L. Bullinger, T. H. Brümmendorf, J. Strobel, H. Hackstein, K. Dornmair, F. Beier, L. Hansmann Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, Berlin; Department of Medicine II, Hematology and Oncology, University Hospital Schleswig Holstein, Kiel; German Cancer Consortium (DKTK), partner site Berlin, and German Cancer Research Center (DKFZ), Heidelberg; Department of Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University; Center for Integrated Oncology, Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen; Department of Transfusion Medicine and Haemostaseology, University Hospital of Erlangen, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen; Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilian-University Munich, Munich, Germany Background: Acquired aplastic anemia is a hematological disease characterized by hypocellular bone marrow with insufficient hematopoiesis and pancytopenia.
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PMC11680982
and triple therapy consisting of standard dose of neratinib group (40 mg/kg, i.g.),
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PMC9031474
Selectivity toward tumor cells preventing off-target effects plays an important role in clinical approval.
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PMC10958426
We analyzed the scRNA-seq data of total 36 samples from 12 CRC patients after integrating data from Lee et al. .
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PMC11388384
Each agent was assigned to a population randomly, such that 5% of the molecules were assigned to the “free” fraction and 95% to the “constrained” fraction.
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PMC11786767
PS is an anionic glycerophospholipid.
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PMC11122631
The similar ECD trends (Figure 5) manifested between compounds 2 and 3 shared the same absolute configuration at those chiral centers.
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PMC11707577
In addition, several other components of the receptor tyrosine kinase family and relative signaling pathway components have been identified, showing considerable structural similarities with their human homologues, , that is the presence of three extracellular immunoglobulin domains (D1‐D3), a transmembrane domain and an intracellular tyrosine kinase domain.
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PMC11267830
h Flow cytometry analysis indicated that the depletion of THOC1 led to a notable increase in apoptosis.
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PMC11745600
As expected, male Ins1 NOG mice had normal sperm motility and fertilization ability (Table 1), allowing the maintenance of homozygous mice using in vitro fertilization.
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PMC11413393
It has been known for some time that biallelic inactivation of the von Hippel Lindau gene (VHL) gene occurs in most cases of ccRCC, leading to complete loss of pVHL and a constitutive activation of the cell’s hypoxia response.
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PMC9429973
V. Paintsil, K. Marfo, F. Adisa, S. Khan, L. M. Tshilolo Kwame Nkrumah University of Science and Technology/Komfo Anokye Teaching Hospital, Kumasi, Ghana; Novartis Pharma AG, Switzerland, Basel, Switzerland; Novartis Pharmaceuticals Inc., United states, Cambridge, United States of America; Novartis Healthcare Pvt Ltd, Hyderabad, India; Centre Hospitalier Mère-Enfant, CEFA/Monkole, Kinshasa, Democratic Republic of the Congo, Kinshasa, Congo, The Democratic Republic of the Background: Clinical trials conducted in Africa have demonstrated the safe and effective use of hydroxyurea (HU) for sickle cell disease (SCD) children in low-resource settings.
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PMC9429973
Aims: PILOT (NCT03483103) evaluated liso-cel, an autologous, CD19-directed chimeric antigen receptor (CAR) T cell product, as second-line treatment in patients with R/R LBCL not intended for HSCT.
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PMC11774251
E-G) Downregulated pathways detected by Gene Set Enrichment Analysis (GSEA).
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PMC11541409
Li, J., et al., Phase 1 study of NB003, a broad-spectrum KIT/PDGFRα inhibitor, in patients with advanced gastrointestinal stromal tumors (GIST).
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PMC8526701
P < 0.05; **P < 0.01.
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PMC10454535
Piceatannol (PIC), a hydroxylated RES derivative, is a known Syk tyrosine kinase inhibitor with anti-cancer and anti-inflammatory effects .
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PMC4112127
The median age of the patients at the time of the resection was 61 years, with an interquartile range (IQR) of 51-75 years (Table 1).
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PMC11409031
Thus, a comprehensive examination of the underlying mechanisms concerning T cells in OV can unveil pivotal immune evasion pathways and novel therapeutic targets.
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PMC11015054
U, V) SMMC‐7721 and HepG2 cell line and HL‐60 cell line cocultured with HL‐60 cell line collected after HL‐60 cells stained with PADI4 protein expression level. *
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PMC5600151
Though cytotoxicity of such PAMAM was more severe than PEI or PLL at the same concentration, the author thought that with some modification there was still a possibility of applying them as a gene delivery platform .
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PMC7519871
The binary combination of cisplatin with WDL in all three sequences of administration resulted in synergistic (0/4 and 4/0 administration) or nearly synergistic (0/0) outcome (Table 2; Supplementary Table for more explanation).
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PMC11413393
c RCC243 cells were treated with indicated doses of MS023, DNA-PK-inhibitor NU7441 or DMSO followed by 10 Gy of irradiation and allowed to recover for the indicated times.
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PMC11783017
Western blotting of Arg-1, CD206, and iNOS in RAW264.7 cells. (
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PMC11747885
Molecular docking studies of 1 with Haemophilus haemolyticus cytosine-5 DNA methyltransferase (MHhal C5 DNMT) demonstrated that SGI-1027 (1) fits within the enzyme's catalytic pocket with its R and R moieties.
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PMC11742231
As shown in Fig. 2, the proposed adaptive fusion module integrates multiple input representations from both representations into a single output.
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PMC11683240
Hence, our results provide the base for further research into details of α1AT expression regulation upon B. pertussis infection.
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PMC11604830
Any effect due to the partial magnetization recovery between the sequence pulses was attenuated by adding two dummy scans before each acquisition.
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PMC10778532
Therapeutical approaches targeting HIF such as VEGF inhibitors are the first-line treatments for ccRCC, but the clinical outcome was disappointing given the drug resistance issue .
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PMC9429973
Complete remission (CR) was defined using standard criteria.
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PMC11564405
These strict procedural adjustments highlight the careful organization of our study within an ethical and diagnostic framework that ensures the credibility and precision of the study.
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PMC6600592
Colorless liquid, yield 81.5%.
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PMC10237474
Although the CHO-K1 host is generally very effective due to its robust growth properties and potential to generate high protein expression titers, clipping of recombinant proteins is sometimes observed.
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PMC11640555
It is known that brain cancer is characterized by uncontrolled cell growth and resistance to cell death, and although NFs are essential for cell growth and differentiation in the CNS , and NFs generated by the tumor cells themselves can stimulate tumor growth .
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PMC11129910
Around 6000 cells were seeded in each well of a six-well plate, and cells were allowed to reach a monolayer confluency.
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PMC9429973
41/45 pts completed 12 cycles of treatment (4 pts came off study prior to C12).
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PMC11612794
Phosphorylated residues of CENP-T may interact with Mis12C basic surface, helping to preclude the mask by increasing the overall affinity of the CENP-T-Mis12C interaction.
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PMC11543885
Plot these terms based on their strength (Log10 [observed/expected]) and false discovery rate (FDR) (interaction score ≥0.7).d.
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PMC11730311
Vasodilative actions of hαCGRP were successfully antagonized by hαCGRP8-37 analogues carrying a C20 diacid at position 25.
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PMC11694066
.
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PMC11429241
The same printing parameters were used as in the case of the basic scaffolds.
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PMC11732635
The gray area indicates the normal range.
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PMC9429973
Aims: In this study, we characterize the functional and mechanistic implications of the long non-coding RNA LINC01547 in acute myeloid leukemia (AML).
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PMC11240448
The values 1/IC50 represent sensitivity of cells to inhibition of the appropriate node, so we expected a positive correlation between global responses of and 1/IC50.
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PMC11451940
Dark-red solid: 32.5 mg (yield 52%).
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PMC9429973
Then the effect of CD16 monocytes on T cells function were elaborated.
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PMC11653533
F. microcarpa is indigenous from Sri Lanka, to southern China, Japan, Australia, and Modern Caledonia, commonly found in coastal zones and topographically disseminated from South, Southeast, and East Asia through Australia and the Pacific Islands (Chan et al., 2017, Lin et al., 2008).
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PMC11574271
HIF-2α serves as a transcription factor for MMP12, promoting its expression and ultimately enhancing the migration and invasion of bladder cancer cells.
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PMC11335267
Food intake was automatically monitored for four consecutive days while the mice were in the metabolic chambers using specific weight sensors connected to the hanging food basket in each cage.
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PMC11755467
A strong reciprocal interdependence has been demonstrated between HIV-1 infection and changes of the intrinsic cellular miRNA milieu.
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PMC11525028
Correlation analysis of NAT10 expression with each of the overlapping 9 genes from (E) in the RNA-seq analysis of osteosarcoma patient samples.
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PMC11727062
Not only that, NRF2 can facilitate tumor cell immune evasion by inducing the metabolism and efflux of chemotherapeutic agents, thereby potentially undermining the effectiveness of immunotherapies (Harder et al. 2017).
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PMC8009078
It can be seen that all molecules follow the LoF and Veber’s rule.
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PMC10362265
Region I showed high fluctuations for all IL18 structures except the computed models (Fig. 2a).
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PMC11638288
Following glucose stimulation, the NKp46 ligand translocates to the cell membrane, leading to the interaction between NK cell-expressed NKp46, and its ligand, which subsequently induces degranulation of NK cells.
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PMC11739504
The NIH/3T3 cells were grown to confluence.
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PMC11297139
n = 10 technical replicate of wound closures.
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PMC11471157
Image showing NIH/3T3 cell spheroids stained for the myofibroblast marker αSMA.
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PMC11806106
We further applied a saturating concentration of DAMGO for normalization, fitted concentration-response curves (Fig. 2E), and calculated EC50-values for each agonist (Table 1).
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PMC11592837
This accumulation can be detected with γH2AX-specific antibodies applying quantitative assays such as Western blotting, Fluorescence-activated Cell Sorting (FACS) or automated fluorescence microscopy .
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PMC8382973
Overall, our data suggest that the safety and ability of 2P23 gels to inhibit HIV infection is independent of rectal and vaginal microbiome differences.
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PMC10936243
An informed consent document was developed, approved and used for the study so that all participants were made aware of the study’s purpose, understood how their data were to be used and handled and understood they could withdraw their data right up until the date of completion of the PhD thesis.
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PMC11747885
RNA integrity was assessed by analyzing the 28S and 18S rRNA, with an RNA 28S : 18S ratio of 2 or greater indicating high quality.
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PMC11185260
To determine the therapeutic potential of scL-SMARCB1 in ATRT, we assessed the response of ATRT xenografts to scL-SMARCB1 treatment.
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PMC11401358
Observations of ROS scavenging in NIH3T3 cells with different polymers using confocal microscopy (Scale bar = 100 μm). (
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PMC11525028
Given that NAT10 may be a potential therapeutic target for osteosarcoma treatment, further exploration of inhibitors would be of great significance for the clinic.
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PMC10812665
A shift from cell differentiation towards continued proliferation (or de-differentiation) is a frequently observed, but unspecific response to toxicant stress.
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PMC11802929
We probed for potential relationships between the physicochemical properties of putative epitopes and the antigenicity of those epitopes.
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PMC10174970
Although they all belonged to the same group, the genomic similarity between cell lines and tumor tissue varied greatly in the same pathway.
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PMC10705095
In contrast, HBQ1, which has been reported to not be expressed in erythrocyte tissues , is a promising candidate for ROS-targeted cancer therapy.
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PMC11711063
HME‐hTert cells exposed to ZG16B‐containing supernatant markedly increased proliferation, which was mitigated by a ZG16B‐specific antibody (Figure 2B).
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PMC11777207
Furthermore, dissociating the cis PD-L1:CD80 heterodimers with the intention of retaining DCs in peripheral tissues is a promising therapeutic avenue in disease contexts where DC-driven downstream adaptive immune responses are unfavorable, such as in the context of transplantation and autoimmune disease, like psoriasis (76, 77).
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PMC11746942
C Immunoblotting and quantification of S1PR3 and P-STAT3 levels in HaCaT cells transfected with a constitutively active STAT3 (STAT3C) plasmid for 48 h. D Chromatin accessibility profile of the S1PR3 promoter region in keratinocytes showing DNase hypersensitivity and histone modifications from ChIP-seq data in the GEO database.
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PMC10957991
Unspecific/low signal was avoided by using thresholding.
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PMC11321678
Then the MB subgrouping result by CpG sites methylation pattern was compared with that by scATAC‐seq data, with principal component analysis and unsupervised clustering (“pheatmap” R package, default clustering parameters).
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PMC10747139
The mechanism of action of these compounds was also deepened by using a colony-formation assay for the SW1573 cells and cell-death-mechanism assay for the HeLa cells.
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PMC7841067
Silencing of AKAP4 inhibited cell migration and invasion.
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PMC11240571
Exosomal PD-L1 exhibited an inhibitory effect on PBMC activation.
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PMC10568263
The Mo 3d5/2 and Mo 3d3/2 peaks with binding energies of 228.8 and 231.8 eV, respectively, are attributed to Mo in 1T-MoS2 for MoS2 materials.
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PMC9429973
Data were collected from April–July 2021.
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PMC9844987
Cross-correlation analysis was performed on either pooled CAGE data (across all 108 LCLs) versus pooled MNase-seq data (across all 7 LCLs) or using only CAGE and MNase data from one LCL (GM18516).
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PMC7823217
These simple cancer models have also played a significant role in pharmaceutical testing.
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PMC11731614
Keratinocyte-derived extracellular vesicles alter their small RNA cargo in painful diabetic neuropathy.
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PMC9429973
However, other studies have raised doubts about high-dose VitC therapy.
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PMC11591794
According to the cell viability results from the MTT analysis, the IC50 values of the vehicle group and the tested groups were calculated using a statistical program.
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PMC7685376
Inhaled carbon dioxide was used to kill the animals while under deep anesthesia with sodium pentobarbital (250 mg/kg, intraperitoneally) at 35 days.
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PMC11423992
Collectively, these results underscore the potential of TFAB002s as a highly promising therapeutic approach for selectively depleting CD20-positive B cells, thereby warranting further clinical evaluation as a viable treatment option for CD20-expressing B-cell malignancies.
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PMC9509578
Their findings indicate that drug-conjugated magnetic nanoformulation activates multiple mechanisms to overcome drug resistance.
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PMC10831439
Altogether, this work reinforces that CAR-iNKT cells are an attractive alternative to CAR-T cells to prevent or treat relapse after allogeneic HCT with the advantage of GVHD prevention and allowing immunostimulatory approaches such as checkpoint inhibition to further strengthen GVL effects.
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PMC9429973
The study was approved by the Institutional Ethics Committee, in compliance with the Helsinki Declaration.
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PMC8316344
The immunoprecipitates that pulled down by IgG antibodies were parallel examined by anti-TFRC antibodies.
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PMC11763764
When ovarian cancers recur, they are usually widespread in the peritoneal cavity and have developed resistance to currently available therapies.
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PMC11604768
Our MPRA plasmid library can be used to survey over five hundred thousand barcoded plasmids representing 6144 synthetic promoters of less than 250 bp in length, containing candidate TREs derived from the ex vivo binding motifs of 229 human and mouse TFs.
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PMC9895440
h Expression of CCR7 measured by flow cytometry antibody staining in Tex.
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PMC11451940
Found (%): C 57.6, H 4.1, N 8.7.
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