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OTAR3088
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BioData-CellLine_annotated

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PMC6934009
Scutellaria belongs to Labiatae family consisting around 400 species of annual and perennial herbs (7).
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PMC11025866
The sequencing data as fastq files were uploaded to the Galaxy web platform at www.usegalaxy.org .
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PMC11615743
It is believed that the high stability of L‐DNA and the high efficiency of the devices for labeling cell subpopulations will have broad applications in the life sciences, biomedical engineering, and personalized medicine.
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PMC11487720
When COS7 cells were exposed to UV and incubated at room temperature for 2 h, the cells failed to exclude trypan blue (see red arrows; Fig. S2A).
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PMC11590870
Regarding the use of antioxidant molecules, natural ones are preferred over chemically synthesized ones.
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PMC10745221
In the ADMA immunoblot, a histone band near 15 kDa appears more strongly in the 143B-P cells than in the 143B-R cells (Fig 4).
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PMC10988555
DMSO at 0.1% (v/v) was used as the negative control and 0.4 μM DOX and 5 μM cisplatin were used as positive controls.
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PMC11612508
The reaction was controlled to stay under 35 ◦C by gradually introducing 11 g of KClO3.
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PMC11763126
C GO analysis (biological process).
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PMC11633763
Expectedly, USP22 knockdown decreased β‐catenin levels in 143B cells, whereas USP22 overexpression in U2OS cells increased β‐catenin levels (Figure 6D,E).
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PMC11638255
Schematic created in BioRender.
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PMC11657695
A Gene expression (Log2 normalized expression) of genes encoding voltage-dependent potassium channels (KCNA1, KCNA2, KCNA3, KCNA4, KCNA5, KCNA6, KCNA7 and KCNA10) in Ewing sarcoma patients (117 patients) (Kruskal–Wallis and Dunn’s tests).
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PMC11279598
Tamoxifen is widely used in the clinic as an antiestrogen therapy, with evidence showing a significant reduction in BC mortality in ER-positive early BC.
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PMC11767793
As shown in Figure 4b, the spectrum of the supernatant after the first CF shows a shoulder between 300 nm and 350 nm and further absorbance below 300 nm, which corresponded to the elevated absorbance of the test suspension of the Au-PEI@NIST in the same range (Figure 4a).
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PMC10812665
Such data have contributed to the development and testing of the adverse outcome pathway (AOP) on complex I (c-I) inhibitors leading to parkinsonian motor deficits (AOP:3) .
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PMC11247842
On BTA2, the MTAG_SCS did not identify a genome-wide significant association, but detected one QTL for CM, which was similar to the MR-MEGA_CM result.
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PMC10955424
The immunoblot experiments were performed twice with comparable results.
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PMC11564405
Table 1Relationships between RILPL2 expression and clinicopathologic features in 140 patients with primary NSCLCVariablesNo.
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PMC5308810
All the aforementioned studies suggest that CXCR4 can be an important target for OVC treatment.
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PMC4277423
Briefly, we downloaded a BED file from the UCSC Genome Browser (http://genome.ucsc.edu/cgi-bin/hgGateway).
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PMC11792090
Evaluation of expanding folds of SAP UCAR-T cells generated from small scale and large scale production. (
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PMC11805741
A scratch wound healing assay was performed to assess the wound healing effect of pigment on MDA-MB-231 cells.
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PMC11222184
Wolvetang et al. demonstrated that overexpression of ETS2 induces p53-dependent apoptosis .
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PMC11640476
Following an overnight (ON) incubation under standard culture conditions to ensure a firm attachment to the plate, the medium was gently removed, and 100 µL of resazurin WS was added to each well.
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PMC10607604
Additional studies are now required to determine the fine mechanism of this platinum sensitization and to define the value of PTPN13 as a predictive marker of response to platinum salts and to therapies targeting DNA damage repair, such as PARP inhibitors.
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PMC6461034
In substrate‐centric analyses; instead, substrate phosphorylation is used to deduce kinase activity indirectly through kinase–substrate relationships (based on either experimental knowledge in PhosphoSitePlus or motif‐based prediction by NetworKIN).
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PMC9813422
More recently, Tang et al. showed alterations in the episomal tethering sites of the host chromosomes caused by the HBV-ΔX mutation.
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PMC11750165
By treating PEX1::Tg[hsp70-Mib:EGFP] zebrafish with retinoic acid at several stages, the formation of secondary motor neurons and KA” neurons could be observed.
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PMC11258145
Intermediate positions along the acyl chain are less affected.
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PMC9895440
The purified RNA was quality-checked on the Bioanalyzer instrument (Agilent Technologies, Santa Clara, CA, USA) using the RNA 6000 Pico Chip (Agilent, Cat# 5067-1513).
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PMC11033180
∗p < 0.05 Kruskal-Wallis test, supplemented by Dunn’s post-hoc test.
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PMC9429973
Mouse studies using the murine analog (RAP-536) was shown to promote erythropoietin (EPO)-independent maturation of late-stage erythroid cells and to increase RBC and hemoglobin (Hb) in a dose-dependent manner (Suragani et al., 2014).
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PMC11714165
The cells also secrete large amounts of cellular factors, including interleukin (IL)‐6, 8, 11, and matrix metalloproteinases (MMPs), which activate the differentiation and hyperfunction of osteoclasts, weakening the bone‐forming capability of osteoblasts.
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PMC10213179
Bands were quantified using ImageJ. Aptamer serum stability was measured in 50% human serum at the indicated times (A) At each time point, RNA-serum samples were collected and evaluated by electrophoresis in a 15% denaturing polyacrylamide gel.
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PMC4270159
A. Loading control.
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PMC11754094
P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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PMC11506827
This highlights the potential of GEFs to sensitize RCC cells to TRAIL-induced apoptosis and offers a promising therapeutic strategy.
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PMC10669128
Visceral sarcomas mainly occur in adults and include several histotypes, including liposarcoma (LPS) and angiosarcoma (AS), as well as some leiomyosarcomas (LMSs) and undifferentiated pleomorphic sarcomas (UPSs).
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PMC9503669
Hck is expressed in macrophages and other HIV target cells , and Nef-mediated Hck activation drives multiple Nef functions including replication enhancement and MHC-I downregulation as described above .
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PMC11001582
Here, we generated C9orf72 DPR knock-in mouse models characterized by expression of either polyGR or polyPR combined with heterozygous C9orf72 reduction, to more accurately model DPR-induced dysfunction in C9ALS/FTD.
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PMC10907726
The RNA sequencing data that support the findings of this study are accessible in the NCBI Sequence Read Archive (SRA) and can be found at https://www.ncbi.nlm.nih.gov/sra.
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PMC9429973
Methods: All individuals above >18 years old with available myeloid and lymphoid peripheral blood counts were selected to study myeloid skewing (n=144676).
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PMC11269933
All statistical analyses were performed using GraphPad Prism version 8.0.2 for Windows.
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PMC2196094
To address these questions, cDNA libraries were constructed from freshly isolated rat peritoneal MCs and from the rat mucosal MC line RBL-1.
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PMC9429973
Image: Summary/Conclusion: In our FL series, the combined “PET/CT or BMB positive” was the only BMI variable that showed an independent prognostic value in FL.
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PMC9429973
A prediction rule could be useful to improve test utilization.
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PMC11529598
Glioblastomas are also a major cause of brain tumor related deaths .
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PMC11574029
Data are presented as the mean ± SEM of three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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PMC11748335
Our results suggest that long LOCKs may be associated with inhibitory effects on the genes within them.
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PMC8996378
Compounds 55 and 57 showed very strong activity compared with the positive control verapamil (FAR = 110.4 and 216.8 at 4 μg/ml, respectively) (Duarte et al., 2007).
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PMC11551844
AuNPs have been successfully synthesized using hexane (JDH), ethyl acetate (JDE) and sterols (JC-2) obtained from the marine sponge Jaspis diastra under new synthesis conditions.
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PMC11388384
Additionally, observation of molecules that transition between the “free” population and alternative SHH-specific biochemical populations suggests that molecules in all populations are structurally intact, and do not reflect a cleaved Halo tag or free fluorophore.
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PMC11673128
After washing with PBS, tumoral cells were resuspended at a concentration of 20 × 10/mL and labeled with 10 μM of CFSE for 10 min in the dark at 37 °C; the reaction was then stopped with RPMI 1640, supplemented with 10% FBS, for 5 min in the dark at room temperature; cells were finally washed twice with PBS and resuspended with serum-free IMDM.
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PMC11535726
Bootstrap support values for Maximum Likelihood (ML) equal to or greater than 75% and Bayesian posterior probabilities (PP) equal to or greater than 0.95 are shown above the nodes.
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PMC6461034
Carefully remove most supernatant while staying away from the bead pellet, allowing some supernatant to remain on the beads.
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PMC11467964
Patients with high risk scores have lower OS in age (p < .001 for >60 years and p = .006 for ≤60 years), gender (p < .001 for female and p = .002 for male), margin status (p = .003 for negative and p < .001 for positive), metastasis (p < .001 for no and p = .010 for yes), and new tumor event (p < .001 for no and p= .003 for yes) (Supporting Information S1: Figure S5a–j).
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PMC11750161
Rmax average cAMP level/10 cells.
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PMC6799808
Collectively, these results suggest that GLPT inhibits mTORC1 in part by activating AMPK and inhibiting Rheb in addition to suppressing the IGFR-PI3K pathway.
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PMC11365427
K, L) Representative 3D micro-CT images and bone parameters of the distal femur and lumbar vertebrae from each group.
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PMC9822769
The mother solutions were diluted in a complete medium to the required concentration.
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PMC11291490
Our findings unequivocally established the evolutionary conservation of dusCD40L across avian species.
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PMC11680049
The results of the fungicidal activity studies of the extract samples against F. oxisporum at the tested concentrations are presented in Table 2.
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PMC11335267
Despite these striking similarities, we observed that Alx3-deficient mice exhibit increased expression of Mc3r in the hypothalamus, and confirmed that these receptors are functional as indicated by the transient increase in food intake observed after administration of the selective MC3R agonist D-Trp8-γMSH, consistent with previous observations .
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PMC11730000
In particular, it is a natural antioxidant that can compete with unsaturated fatty acids for binding to lipid peroxyl groups to terminate the chain reaction of lipid peroxidation and reduce the rate of lipid peroxidation.
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PMC11680049
Lyophilized samples were dissolved in 96% ethanol to a final concentration of 100 mg/mL based on dry weight.
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PMC11363012
In leaves, we observed a subpopulation of cells that specifically accumulate loganic acid (1) (Figure 5a).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "leaves", ",...
PMC9429973
We present results of a follow-up on patients treated in the safety run-in phase.
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PMC9429973
Summary/Conclusion: There was a moderately high prevalence of undiagnosed beta-thalassemia minor, and presently the uptake of the current voluntary screening program is limited in India.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8481254
Additionally, Senexin B treatment resulted in a significant suppression of OGT, YAP, and O-GlcNAcylation levels, cell proliferation, and colony-formation capacity in both Bel-7402 and Bel-7404 cells (Fig. 6F, G).
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PMC10914904
In contrast, vtRNA 2-1 can sequester the PKR protein, inhibiting activation of the NF-κB signaling pathway.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", ...
PMC10470467
Meanwhile, we explore whether these molecules are essential for ES cell line growth through the DepMap, a resource of genome-wide CRISPR-Cas9 knockout screens in hundreds of cancer cell lines.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10094992
Despite scientific advances, treatment options for MPM remain limited, with no approved second line therapies available.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "scientific", "advances", ",", ...
PMC9429973
C. Carlo-Stella, S. Ansell, P. L Zinzani, J. Radford, K. Maddocks, A. Pinto, G. P. Collins, V. Bachanova, N. Bartlett, I. Bence-Bruckler, M. Hamadani, J. Kline, J. Mayer, K. J. Savage, R. Advani, P. Caimi, R.-O. Casasnovas, T. Feldman, B. Hess, M. Bastos-Oreiro, S. Iyengar, S. Eisen, Y. Negievich, L. Wang, J. Wuerthner, A. F. Herrera Department of Oncology and Hematology, Humanitas Clinical and Research Center - IRCCS and Humanitas University, Rozzano, Milano, Italy; Division of Hematology, Mayo Clinic, Division of Hematology, Minnesota, United States of America; Hematology, Institute of Hematology Seràgnoli University of Bologna, Bologna, Italy; NIHR Clinical Research Facility, the Christie NHS Foundation Trust and University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Division of Hematology, Ohio State University Medical Center, Columbus, United States of America; Fondazione G. Pascale, IRCCS, Istituto Nazionale Tumori, Naples, Italy; Oxford Cancer and Haematology Centre, NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, United Kingdom; Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis; Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, United States of America; Ottawa-Hospital General Campus, The Ottawa Hospital-General Campus, Ottawa, Canada; Medical College of Wisconsin, BMT & Cellular Therapy Program, Department of Medicine, Milwaukee; Department of Medicine, The University of Chicago, Chicago, United States of America; Internal Medicine, University Hospital and Masaryk University, Brno, Czechia; Department of Medical Oncology, BC Cancer and University of British Columbia, Vancouver, Canada; Division of Oncology, Department of Medicine, Stanford University, Stanford; Cancer Center, Cleveland Clinic/Case Comprehensive Cancer Center, Cleveland, United States of America; Department of Hematology, University Hospital F. Mitterrand and Inserm UMR 1231, Dijon, France; John Theurer Cancer Center, Hackensack Meridian Health, Hackensack; Division of Hematology and Medical Oncology, Department of Medicine, Medical University of South Carolina, Charleston, United States of America; Haematology Department, Gregorio Marañón Health Research Institute, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Royal Marsden Hospital, London, United Kingdom; ADC Therapeutics SA, Epalinges, Switzerland; ADC Therapeutics America, Inc, Murray Hill; Department of Hematology & Hematology & Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, United States of America Background: Camidanlumab tesirine (Cami), an antibody-drug conjugate comprising a human IgG1 anti-CD25 monoclonal antibody conjugated to a pyrrolobenzodiazepine (PBD) dimer, displayed antitumor activity and manageable toxicity in a phase 1 trial in lymphoma, including R/R cHL (Hamadani et al. 2021).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5261804
The gene symbols for the PID pathway were first mapped to the official HUGO symbols to resolve ambiguity and aid in integration with the Achilles dataset.
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PMC11768927
The majority of these cell lines were sensitive to VSV; however, 12 out of the 33 retained a functional IFN pathway and were resistant to VSV.
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PMC9592219
Serum-free medium was used for cell starvation for 24 h. HCC cells 2 × 10 cells in 200 μl serum-free media were implanted in the upper chamber (8.0 μm pore size; Corning, Inc.) that was precoated for 8 h with 90 μl Matrigel (BD Biosciences) at 37°C.
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PMC11185260
During the treatment period (between days 8 and 26), there was significant inhibition of tumor growth in animals receiving scL-SMARCB1 (1.6-fold increase from their initial tumor volume) compared to animals without any treatment (3.5-fold increase from their initial size) (Figure 4B).
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PMC11686380
Total dendritic length was also significantly reduced in the knocked-down neurons (Fig. 4C).
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PMC10297204
Accumulated reliable data on the anti-tumor effects of ethanol and its toxicity are lacking in orthopedic oncology and are necessary to establish its pros and cons.
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PMC11788920
As c-Myc is critical for cell proliferation and is upregulated in diverse cancers, effective suppression of its expression is desirable.
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PMC9844987
E–F) Average nucleosome fuzzy score across all 7 LCLs, split by variability quartiles (E) and minimum correlation between contained decomposed promoter pairs (high Pearson’s correlation >0.39: solid colors, low Pearson’s correlation ≤ 0.39: faded colors) (F).
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PMC11727062
The inclusion criteria encompass randomized controlled trials (RCTs), cohort studies, case-control studies, and both prospective and retrospective analyses that investigate the application of TCM monomers for melanoma treatment, with participants being patients with confirmed melanoma diagnoses.
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PMC9532503
Finally, the luminescence was measured in the BioTek Synergy H1 plate reader (Biotek, USA) and the results were analyzed using customized PLA software.
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PMC11116779
Milan, Italy), following the manufacturer’s protocol, as previously reported (28–32).
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PMC9429973
To generate total quality-adjusted life years (QALYs), these health state utilities and AE disutilities were applied to the relative efficacy data.
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PMC11342785
Two-tailed Student t test; statistical differences: ∗∗∗∗, p < 0.0001; ∗∗∗ p < 0.001; n.s.,
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PMC11781181
Ferroptosis has been recently associated with severe pathological conditions, including carcinogenesis, stroke, kidney ischemia/reperfusion (I/R) injury, and degenerative diseases 6.
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PMC11774251
Statistical significance is indicated as *P <0.05, **P <0.01, ***P <0.001, ****P <0.0001, ns = not significant.
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PMC9429973
Aims: To analyze the frequency and clinical significance of overexpression of the BAALC gene in patients with AML.
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PMC3995603
The detection wavelength was set at 254 nm (I) for hyperoside (3) and isoquercitrin (4), at 320 nm (II) for chlorogenic acid (1), caffeic acid (2), and isochlorogenic acid A (5) and at 340 nm (III) for scoparone (6).
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PMC9429973
Results to date have revealed the diagnosis of 2 ASMD and 4 GD patients derived from the epidemiological program.
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PMC11706776
Western-blots of SK1 and EWS::FLI1 (right panel) in A-673/TR/shEF cell line after doxycycline treatment (1 µg/mL) (N = 2).
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PMC9776316
CellTiter-Glo Luminescent Viability Assay (Promega) was applied to determine the cell viability after 2 days.
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PMC9621239
To dectect the ubiquitination level of MYC, the plasmid expressing MYC-Flag was also co-transfected with the plasmids expressing HBx-WT, HBx-SM, HBx-DM or HBx-TM into Huh 7 cells for 48 h. Then, the proteasome inhibitor MG-132 (HY-13259, MedChemExpress, USA) was added at a final concentration of 20 μM for 6 h before lysis, followed by co-IP and western blot analysis.
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PMC11285179
Data with error bars are shown as mean ± SEM.
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PMC11321678
ATOH1, which is a transcription factor required for GCPs formation and regarded as the marker, expresses in SHH subgroup specifically.
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PMC11594641
Moreover, the high basal level of Rab27A observed in SkMel28 cells did not influence its commitment to sEV release.
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PMC6803987
As shown in Figure 4, treatment of HepG2.2.15 cells with various esculetin concentrations for 9 days resulted in significant reduction secretion of Hepatitis B surface antigen (HBsAg) and Hepatitis Be Antigen (HBeAg) in a time- and dose-dependent manner.
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PMC9926039
All-important active sites of amino acids were involved in the grid box.
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PMC9621239
Therefore, understanding the evolution of the HBV X gene in the HCC microenvironment and investigating the tumour-promoting phenotypes of mutant HBx proteins could contribute to elucidating the pathogenesis of HBV-related HCC.
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