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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
The majority of patients with available data (20/21 [95%]) received intensive, myeloablative conditioning.
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PMC11739504
Acetylated α-tubulin and γ-tubulin were stained for primary cilia (green).
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PMC9872547
The anticancer activity of curcumin against cervical cells was due to the regulation of telomerase activity, Ras and ERK signaling pathways, cyclin D1, COX-2, and iNOS activity, and mitochondrial pathway.
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PMC9429973
Interestingly, in the ELISPOT assay, 4 out the 7 pts showed a significant response towards the ARG peptide, 2 showed a response towards IDO peptide and in 4 of the patients there was a significant response towards the TGFβ peptide.
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PMC11672881
Here, we test the hypothesis that dietary supplements such as thymoquinone (TQ) and curcumin (CU) cooperatively modulate cancer-associated cellular mechanisms to inhibit melanoma progression.
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PMC9429973
Results: According to IMWG criteria, after a median follow-up of 9 months (r.2-18), ORR was 68,2% (28/41: 9 CR, 12 VGPR, 7 PR) with 5 progressive diseases (PD) and 8 patients in stable disease (SD): this can be considered as an impressive result in this subset of rrMM patients, refractory to lenalidomide.
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PMC9429973
Divergently, the now 8-year-old brother who is also carrying the same variant has no clinically apparent phenotype until now.
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PMC11216402
TCGA-STAD mutation rates were downloaded from cBioPortal (Cerami et al. 2012; Gao et al. 2013; https://www.cbioportal.org/study/summary?id=stad_tcga_pan_can_atlas_2018).
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PMC8481254
However, overexpression or knockdown of OGT had no effect on CDK19 expression (Supplementary Fig. 5E).
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PMC11321678
We took two parallel approaches to search for the upstream regulators of key neuron transmitter receptor genes.
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PMC10968586
Glioma, a neoplastic lesion arising from glial cells, is the most frequent tumor of the central nervous system, and glioblastoma multiforme accounts for the large majority of all gliomas.
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PMC10955424
There are five different types of EOC: mucinous, low, and high-grade serous ovarian cancer (HGSOC), endometroid, clear cells, and unspecified.
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PMC11655498
Post-translational modifications (PTMs), such as phosphorylation, ubiquitination, sumoylation, and other covalent modifications are capable of regulating the associated activity of Zta or Rta (Walsh et al., 2005).
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PMC11705547
Yu et al. showed that cisplatin induced G2/M checkpoint arrest and apoptosis in kidney cancer cells, and activated the cGAS-STING signaling pathway by increasing the level of cytoplasmic dsDNA .
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PMC8481254
Scale bars: 20 μm.
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PMC11127909
As Fig. 5E shows, the ADP/ATP exchange rate of the WT group was significantly reduced compared with that of the vector group, while both the ΔN mutant and the ΔE1 mutant reversed this inhibitory effect.
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PMC8143558
The hemolytic concentration of a plant extract also shows its hemolytic strength.
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PMC11721096
For the stability of the recombinant cells, we monitored the enzymatic activity in a consecutive period of 7 days.
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PMC10362265
This mobile region corresponding to the small surface helix almost froze in the computational models, fluctuating less than 2 Å. The computed models did not show any increased fluctuations almost for the entire complex except the C-termini of their decoys (Fig. 2a).
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PMC11224020
Of note, we do not exclude that ARP2/3-dependent forces might also open nuclear pores to enhance cPLA2 translocation from the cytoplasm to the nucleus, similar to what had been shown for YAP/TAZ, thereby contributing to nuclear accumulation of the enzyme.
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PMC11766174
PBMCs were isolated from PLWH on cART using either leukapheresis or whole blood via Ficoll-gradient centrifugation.
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PMC9429973
UCART22 at DL2 and DL2i administered after FCA LD regimen was well tolerated.
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PMC11381192
In the high CSI group, upregulated genes were mainly enriched in cell division events, such as mitotic nuclear division, chromosome segregation, and DNA replication.
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PMC11705547
The development of cisplatin resistance primarily depends on three intracellular adaptive mechanisms: decreased uptake or increased efflux of the drug, inactivation of the drug, or activation of DNA damage repair pathways [90–95].
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PMC11144200
n = 3, ****P < 0.0001.
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PMC10538569
TZM.bl reporter cells were used to evaluate trans-infection by iDC-captured HIV-1.
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PMC9509578
Two modifications were prepared for the purpose of disrupting the tumor detoxification system and overcoming drug resistance in oral squamous carcinoma SCC15/CBP and SCC15/PYM resistant cells, pingyangmycin (MPEG-PLA-SS-ECA/PYM) and carboplatin (MPEG-PLA-SS-ECA/CBP) .
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PMC11705901
SNPs rs2254298 and rs237887 are both associated with ASD .
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PMC10940855
Error bars, SD. **,
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PMC11791478
Remarkably, complete tumor regression was observed in the cervical cancer and head and neck squamous cell carcinoma models within 30 days of treatment.
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PMC9429973
Off note, both patients with COVID19 pneumonia (haploidentical and autologous HSCT respectively) were discharged from ICU and remain alive to date, without major complications.
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PMC9250505
At termination, viability and apoptosis were determined using the ApoTox-Glo Triplex Assay Kit (G6320, Promega, China).
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PMC4485786
Indeed, several studies have shown improved survival of patients with increased frequencies of IFN-γ-producing T cells after allogeneic hematopoietic stem cell transplantation (SCT).
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PMC9429973
In our study, most of them believe new technologies are accessible, useful, and the preferred way to use them is the mobile phone.
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PMC11623887
Their research revealed that increasing FAM122A levels inhibits the generation of red blood cells in both primary human hematopoietic progenitor cells and erythroleukemia cells.
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PMC11172027
Increasing the concentration to 250, 375, and 500 µg/mL NASeLM did not decrease mitochondrial activity any further.
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PMC9681981
According to the findings of the present study, 2 h of bacterial contact with Caco-2 cells could stimulate etx gene expression in the C. perfringens type D vaccine strain.
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PMC10850553
The square in the demagnified image corresponds to the area shown in the magnified images.
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PMC9596868
no. L9283) were purchased from Sigma-Aldrich Co. MST-312 was prepared in 20 mM stock solution and luteolin was prepared in 50 mM stock solution by dissolving them in DMSO.
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PMC7553912
For multiple group comparisons, ANOVA followed by the post hoc Bonferroni test was used.
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PMC11478724
Cell viability was measured at 100% with no intervention and at varying doses using the following formula: To evaluate the cytotoxicity of PMX, the release of LDH into the culture medium as an indicator of cell death was monitored.
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PMC11515150
Sufficient cell expansion and large amount of cells are the crucial issues for clinical application of NK cells.
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PMC6450504
To prepare fluorescently labeled liposomes, Rhod-PE was added in the preparation of the lipid film at a final concentration of 0.1% (%mol of total lipids).
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PMC7823217
Generating bioprinted constructs with well-developed vasculature is particularly important in GBM, tumor characterized by pronounced angiogenesis.
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PMC11768281
Natural Killer T (NKT) cells, traditionally classified as part of the innate immune system, also exhibit characteristics typical of adaptive immune T-cells, highlighting their functional versatility.
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PMC11257203
As the distribution of all data was normal, statistical significance was determined using the one-way analysis of variance (ANOVA) test followed by the Tukey post hoc test.
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PMC11591030
Notably, the LPS + PDTC + AOP group showed significantly lower Keap1 gene expression compared to both the LPS + AOP and LPS + PDTC groups (p < 0.05).
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PMC10154097
Finally, RNA was isolated from beads to estimate relative enrichment .
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PMC11395280
We concluded that CCL198-83 at 200 nM should be able to inhibit CCL19-medicated CNS invasion of T-ALL across the BBB but not CCL21.
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PMC10551595
A p‐value ≤ 0.05 was considered statistically significant.
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PMC9429973
Reversal of hematological parameters during dosing interruption further confirms the effect of Rusfertide on both iron homeostasis and erythrocytosis.
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PMC9429973
Peripheral blood mononuclear cells (PBMCs) isolated from healthy donors were stimulated with AML blasts and morphogenetic protein 2 (BMP2) to validate clinical phenotypes.
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PMC10944868
This explains some of the side effects associated with these drugs, such as bone marrow suppression, peripheral neuropathy, and gastrointestinal problems (Dumontet et al., 2010).
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PMC11754291
Melanocyte protein extraction was performed using a lysis buffer containing 1% (v/v) NP40 (Biobasic, Markham, Ontario, Canada), 1% (v/v) Triton-X-100 (Bio-Rad, Hercules, CA, United States), 0.1% (w/v) SDS (Bio-Rad, Hercules, CA, United States), and 0.5% (w/v) Sodium Deoxycholate (Fisher Chemical, Waltham, MA, United States) in PBS.
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PMC11547972
Then, protein bands were analyzed using the Fusion FX7 system (Peqlab, Erlangen, Germany).
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PMC8708099
At subsequent time points, FXF and osthole did not significantly increase cell proliferation (with the exception of 300 ng/mL osthole at 48 h).
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PMC7090062
Specifically, we confirm that in GIST cells, beclin-1 is a target of miR-30, which is consistent with reports of other cancer types.
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PMC11477621
The results were displayed as Mean ± SD.
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PMC11092382
Using different mouse models, such as carrageenan-induced rat hind paw edema, xylene-induced mouse ear edema and acetic acid-induced mouse vascular permeation, sophocarpine was found to possess analgesic and anti-inflammatory properties (Gao et al., 2009) and anti-inflammatory activities via the possible mechanism of affecting Ca influx and inhibiting the secretion of inflammatory factors (Wang et al., 2021b).
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PMC11743975
COS-7 cells were transfected with Tom20-CIBN-GFP and mCherry-CRY2clust plasmids.
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PMC11437637
We found that Mets also had an impact on immune function in patients with EC.
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PMC11472639
indicates a significant difference from pre-exercise at p < 0.01.
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PMC11345828
Structural studies were performed as previously described.
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PMC11583010
After three washes with PBS 0.05% with Tween 20, the wells were saturated with PBS BSA for 2 hours at 25°C and then washed three times with PBS 0.05% with Tween 20.
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PMC10968586
This result matched another report documenting that the consumption of HT-enriched biscuits (containing 5.25 mg HT) determined the appearance of HT metabolites in the volunteers’ plasma between 30 min and 1 h .
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PMC11789597
A heatmap showing the expression of cell metabolism‐related genes in MM cells expressing shNC or shCAV1.
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PMC11680982
We knocked down HER2 in HR/HER2-low breast cancer cells and found no difference in the inhibitory effects of the three-agent regimen including CDK 4/6 inhibitor, endocrine therapy combined with neratinib on cell proliferation.
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PMC9014716
P < .05, **P < 0.05 represents statistically difference.
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PMC9429973
At registry enrollment, median hemoglobin (range) in the M/M, M/NM, and NM/NM cohorts was 9.9 g/dL (7.1–14.2), 9.1 g/dL (6.7–14.1), and 7.3 g/dL (6.9–8.1), respectively.
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PMC9429973
Most patients (87.3%) trusted in the safety of clinical trials.
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PMC11463018
This result establishes 19 to be a JAK1/2 inhibitor.
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PMC11756514
no. 7406404, Lampire biological laboratories) in HBS+, 1% goat serum and washed twice with HBS+, 0.2% goat serum.
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PMC11734514
The extracted protein samples (10 µL/lane) were separated by 10% SDS-PAGE in the electrophoresis tank (Invitrogen) and were subsequently transferred to a nitrocellulose membrane by adopting a blot transfer device (Invitrogen).
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PMC9444294
PLA detects close physical proximity between target proteins, by conjugating two protein-specific antibodies (derived from two different species) to oligonucleotides that, if their targets are in proximity, can subsequently be ligated and amplified using fluorophore-labelled primer sequences.
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PMC11388384
Transition probability per 6 ms frame as a function of SCUBE1 concentration.
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PMC11779605
Our study contributes new information that FGF7 protein also has prognostic significance for patients with ovarian cancer.
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PMC11502066
These effects can be achieved by either modulating the expression levels of GPCRs in cell membrane or behaving as competitive antagonists impeding the binding of endogenous ligands to their receptors and inhibiting the subsequent tumor-promoting activities .
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PMC11766174
To determine the standard curve, HIV RNA was extracted from the MOLT IIIB cell line and quantified using the QuantStudio 3D digital real-time PCR system (QuantStudio 3D Analysis Suite Cloud Software, 15 April 2016, Thermo Fisher Scientific, Carlsbad, CA, USA).
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PMC9429973
Results: As of April 2021, 193 patients enrolled in EXPLORER (n=86) and PATHFINDER (n=107) were included in analyses with centrally confirmed diagnoses of aggressive SM (n=29), SM with an associated hematologic neoplasm (n=119), mast cell leukemia (n=28), indolent SM (n=14), smoldering SM (n = 2) or CMML (n=1).
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PMC11727062
Additionally, it downregulates the expression of glucose transporters GLUT1 and GLUT3, along with key glycolytic enzymes, suggesting an inhibitory effect on melanoma cell glycolysis.
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PMC9592219
TOP2A overexpression reversed the effect of miR-22-5p.
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PMC9429973
Results: 381 pts with MF were identified, 29 (8%) of whom were SF3B1.
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PMC11306331
Together, these results show that OptoMBP-based dissolution generalizes outside of the FET family to additional types of condensate-forming proteins in both the nucleus and cytoplasm.
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PMC10362265
MDAnalysis was used to plot all-to-all RMSD heatmaps , .
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PMC5417661
All animal assays and handling were approved by and conducted in compliance with the policies of the Institutional animal care committees of the Experimental Pharmacology & Oncology Berlin-Buch GmbH (Berlin, Germany) and In Vivo Design AB (Uppsala, Sweden) that fully meet the ethical and legal requirements as defined in the 2010/63/EU directive and national animal protection laws of German and Sweden.
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PMC10213179
In recent years, accumulated evidence has suggested that EphA2 and its ligands influence human cancer initiation, tumor growth, and metastasis.
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PMC10362265
This change approximately corresponded to a Cα-RMSD of 8 Å. The viral decoy from ectromelia virus (3f62) also showed high mobility (Fig. S1a).
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PMC11794847
Metabolic reprogramming is not solely a hallmark of tumor cells; it is crucial for various immune cells, including T cells.
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PMC11564405
Dominating the landscape of lung malignancies, NSCLC commands a formidable presence, encompassing an overwhelming 85% of reported cases, and adds to this daunting scenario.
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PMC11802929
Fig. 4Pep-Groups associate with different T cell phenotypes.a Illustration of the mapping of peptide physicochemical properties on to T cell gene expression profiles.
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PMC11754094
It is possible for variant candidate read pairs to be present in non-treated samples, primarily due to inherent biases associated with PCR amplification.
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PMC9429973
Aims: to compare morphological consistency and immunohistochemical characteristics of PCM substrate in bone marrow trephines and bone plasmacytomas biopsy specimens.
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PMC10849234
We analyze primary granule exocytosis, as well as markers for other secretory organelles, and we examine both a classical and newer differentiation protocol to generate the NLCs.
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PMC11502066
The role of flavonoids is shown by red color.
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PMC10761218
This gap persists despite the extensive utilization of W. somnifera in various studies pertaining to anticancer properties.
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PMC9895440
Cells were then washed twice in FACS buffer and then fixed with 4% PFA in PBS and incubated for 20 min at RT.
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PMC11591030
However, their application in animal husbandry still demands extensive research and development.
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PMC8956657
The region responsible for nuclear localization is contained with the N-terminus and spans two sites within residues 19-39.
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PMC11351758
Coenzyme Q10 (CoQ10) is another mitochondrial antioxidant that is not easily absorbed by the body, with a significant amount of it not reaching the mitochondria when taken as supplements.
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PMC11745600
Blue, red, and purple lines indicate mice implanted with 3 (male; M1 and M2), 2 (female; F1), and 1 (female; F2 and F3) insulin tablets, respectively.
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