OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11742864	Yuanyuan Liu et al. revealed that the levels of pro-apoptotic factors BAX and Caspase-3 were upregulated after DHA and EPA treatments while downregulating the anti-apoptotic factors Bcl-2 and Bcl-xl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8996378	Some lathyrane-type diterpenoids, including compounds 52–54, were isolated from Euphorbia lagascae (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "lathyrane-type", "diterpenoids", ",", "in...
PMC11367146	Then, the refined core proteins and core compounds were uploaded to the PyRx tool for docking.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "refined", "core", "prot...
PMC10443665	All experiments were conducted with cells in the logarithmic growth phase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "conducted", "with", "cells", "in", "the", "logarithmic", ...
PMC11773391	The transcriptional activity of the MGMT promoter can be reflected by luciferase expression (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transcriptional", "activity", "of", "the",...
PMC10125312	Hek293 also had lower uptake than the other noncancerous cell lines studied, showing a trend in kidney cells with a lower uptake of AuNR-PEG in vitro compared with lung or liver cell lines under the same conditions.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653533	Ordinarily; fruits, airborne roots, bark, and leaves as well as entire trees are traditionally related to diarrhea, dysentery, menorrhagia, anxious, and tonic properties; but, concurring to Ayurveda it is primarily utilized for the treatment of diabetes (Verma et al., 2015).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747139	Inside the tumor, Ru(III) is proposed to be activated by its reduction to Ru(II) due to prevalent reductive conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inside", "th...
PMC4277423	In the present study, we silenced CCR5 via CRISPR associated protein 9 (Cas9) and single guided RNAs (sgRNAs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC8633974	U1 and JLat cells contain one or more integrated copies of the viral genome in each cell.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "U1", "and", "JLat", "cells", "contain", ...
PMC11803918	After 1 h, tumor tissues were irradiated for 10 min using red light LED (650 nm, 100 mW/cm, 10 min).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11407042	•Incorrect wavelength of the plate reader may lead to low absorbance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "•Incorrect", "wavelength", "of", "the", "plate", "reader", "may", "lead", "to", "low"...
PMC11742864	Here we present the key roles of ω-3 LCPUFAs as dietary supplementations in lung cancer, comprehensively review the recent progress on the underlying mechanisms of cancer cell regulation by ω-3 LCPUFAs, and introduce the application of ω-3 LCPUFAs in the clinical management of lung cancer and its malignant complications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	Moreover, UPR is involved in mutant protein folding, which also indicates that UPR might be involved in ERQC bypass and Golgi retention of MT-KIT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11387401	Altogether, our small-scale ASO-mediated screen to probe the functional effects of HIV-1 protein-interacting RNAs on HIV-1 replication indicates that this HIV-1 protein–host RNA dataset is a valuable source for HIV-1 research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8526701	The rate of apoptotic induction using 0.5 μM GSK602 was considerably lower in PUMA-KO cells than in WT GIST-882 cells (Fig. 3E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "token...
PMC11023271	We have previously shown that down-regulation of RIPK4 led to enhanced cell proliferation in keratinocyte- or SCC-derived cell lines .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "previously", "shown...
PMC10606998	A weak radiosensitizing effect was found only in the Gl-Tr line for the 1.2 MeV gamma irradiation and there was no radiosensitizing effect in both lines for the 200 MeV proton irradiation at the Bragg peak.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10938336	The substantial degree of connectivity associated with these hub genes underscores their prominence in the PPI network and suggests their indispensable roles in mediating interactions between various proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9841531	A PI/Annexin V-FITC double staining method was used to carry out a flow cytometry-based apoptosis assay, as reported earlier.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "PI/Annexin", "V-FITC", ...
PMC11502962	The MIF/CXCR4 axis could contribute to drug resistance in tumor invasion and metastasis (41, 43).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "MIF/CXCR4", "axis", "could", "c...
PMC11721277	The volume of the aliquot applied to the column is 3.00 μL. The detection of compounds was carried out in the mode of detecting positively charged ions during heated electrospray ionization (HESI).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786704	By reducing the generation of ROS, the PC capsule effectively protects cells from oxidative stress damage, which in turn promotes cell survival and wound healing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11674441	The purity of the isolated CD8-positive and CD4-positive T cells was determined via flow cytometry and exceeded 97%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "purity", "of", "the", ...
PMC9429973	The median OS and DFS of the entire cohort were respectively 41.9 and 37.6 months, with an OS and DFS at 5 years of 43% and 39%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10669128	As a result, FUS expression in CHOP transgenic mice restored liposarcoma development, indicating that the FUS and CHOP domains cooperate in mutual liposarcoma restoration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11633763	OCR values of USP22 silenced 143B cells with and without HK2 overexpression. *	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OCR", "values", "of", "USP22", "silenced", "143B", "cells", "with"...
PMC11402217	This research presents the anticancer agent XD23, which modulates DKK1, thereby influencing Wnt/β-catenin signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "research", "presents", "the", "anticancer", "a...
PMC9429973	Limited data is available on the relationship between the SARS-CoV-2 vaccine and the development of aplastic anemia (AA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Limited", "data", "is", ...
PMC10818573	Nfo was added to cut off the C3-Spacer of the 3′ end of the probe to obtain a new target fragment with both labels and eliminate the interference of the primer dimer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11401350	mean (SD); (A,B) No vector d3 n = 4, d6 n = 4; PGK-GFP d3 n = 5, d6 n = 3; PGK-CAR d3 n = 7, d6 n = 4; EF1a-GFP d3 n = 3, d6 n = 3; EF1a-CAR d3 n = 3, d6 n = 3 n = 4; p < 0.01; (C,D), No vector d3 n = 7, d6 n = 6; PGK-GFP d3 n = 5, d6 n = 5; PGK-CAR d3 n = 7, d6 n = 4; EF1a-GFP d3 n = 3, d6 n = 3; EF1a-CAR d3 n = 3, d6 n = 3; p < 0.01, ***p < 0.001; multiple t-test). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740399	Mechanistic studies showed that 3025@ML inhibited the PI3K/AKT/mTOR signaling pathway and reduced the expression of key metabolic regulators PKM2 and FASN.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanistic", "studies"...
PMC9429973	In each group patients received 60mg of elemetal iron.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "each", "group", "patients", "received", "60", "mg", "of", "elemetal", "iron", "." ...
PMC10858941	However, in the case of the A-172 cell line, which exhibited higher on-chip metabolic activity than the U-251 MG line (Suppl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O"...
PMC11762280	Human skin samples of sun-exposed and non-exposed areas were collected and performed immunohistochemical studies for N-GSDMD, cleaved PARP, and p-MLKL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Human", "ski...
PMC9219615	Approximately 20,000 events (cells) were acquired per sample.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Approximately", "20,000", "events", "(", "cells", ")", "were", "acquired", "per", "sample", ...
PMC9429973	There is no gold standard intensive CIT regimen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "no", "gold", "standard", "intensive", "CIT", "regimen", "." ] } ]
PMC11796104	KEGG pathway enrichment analysis indicated that several pathways were significantly enriched, including Metabolic pathways (p = 2.17E-12), RNA transport (p = 9.92E-11), Ubiquitin mediated proteolysis (p = 3.32E-09) and Amyotrophic lateral sclerosis (p = 1.79E-08) (Fig. 3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502962	Human GIST cells GIST882 with a mutation in KIT exon 13 were provided by Jonathan Fletcher (Dana-Farber Cancer Institute, Boston, MA) (19, 20).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: We hypothesised that impairment of T cell receptor (TCR) signalling through off-target binding of Src kinases, including Lck, would be an additional mechanism of immune dysfunction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721064	Morphological analysis revealed pronounced fibroblast contamination in cultures using dKSFM and SHEM, while SKCs maintained a relatively uniform keratinocyte morphology and predominant growth in KSFM (Additional file 1: Fig. S2B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	Overall, the addition of TETA to anti-GD2 therapy significantly extended survival when compared to the respective monotherapy arms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "the", "addition",...
PMC5673955	N = 4.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "N", "=", "4", "." ] } ]
PMC11803918	Antibodies used for immunofluorescence and flow cytometry and their origin were listed in Table S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antibodies", "used", "for", "immunofluorescence", "and", "flow", ...
PMC11665584	This study demonstrates that PITX1 is a powerful driver of an oral keratinocyte transcriptional program that has pleiotropic effects on keratinocyte lineage and interactions with other tissue-resident cells and on overall tissue morphology.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774112	The inhibitory effect of PHRD-DTIC was greater than that of free DTIC at almost all concentrations, probably due to the rapid uptake of nanocarriers with a size of ~150 nm and the sustained release of DTIC from PHRD-DTIC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6627640	Importantly, repression of H3K27 methylation conferred cisplatin resistance to parental cells while induction of H3K27 methylation resulted in an increased cisplatin sensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importa...
PMC11126803	Ethical Approval and consent to participate Ethical consent was approved by the Human Subjects Research Ethics Review Committee of the Tianjin Third Central Hospital affiliated to Nankai University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The methods of descriptive (mean ± standard deviation, median (range), frequency (%)) and analytic statistics (Student’s t-test, chi-squared test) were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11650848	The ZFP57 protein and its cofactor KAP1 recruit the H3K9 methyltransferase SETDB1 and DNA methyltransferase (DNMT) enzymes to maintain histone and DNA methylation marks at ICRs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	E. Dann, T. Inbar, T. Mashiach, J. Eisa, S. Ringelstein-Harlev, N. Horowitz Rambam Health Care Campus; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel Background: In patients (pts) with hematological malignancies, COVID-19 is considered to be associated with a high risk of severe morbidity and mortality.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7504302	Suggestive of a therapeutic role, ERβ silencing sensitized REN cells to Gefitinib treatment .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Suggestive", "of", "a", "therapeutic", "role", ",", "ERβ", ...
PMC11748335	No significant motifs were found in the NE2 vs KYSE510 group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "significant", "motifs", "were", "found", "in", "the", "NE2", "vs", "KYSE510", ...
PMC11476666	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH, forward primer 5’-TGGTATCGTGGAAGGACTCATGAC-3’, reverse primer 5’-ATGCCAGTGAGCTTCCCGTTCAGC-3’) was used as internal reference and co-amplified with target samples using identical experimental conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4369959	Ginger and its components have been shown to modulate a wide range of signaling molecules (Figure 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ginger", "and", "its", "component...
PMC9429973	Aims: DREAMM-6 (NCT03544281) Arm A is evaluating belamaf in combination with LenDex in patients with RRMM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "DREAMM-6", "(", ...
PMC11782780	Cells were cultured at 37°C with 5% CO2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "cultured", "at", "37", "°", "C", "with", "5", "%", "CO2", ...
PMC6742971	The effector to melanoma cell ratios were 30:1, 10:1, 3:1, 1:1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effector", "to", "melanoma", "cell", "ratios", "were", "3...
PMC11627398	ROC curves verified the diagnostic value of SLC31A1, MTF1, LIAS and LIPT1 genes in the GSE26640 cohort. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ROC", "curves", "verified", ...
PMC11541409	As the landscape of GIST treatment continues to evolve, an integrated, multifaceted approach involving novel TKIs, combination therapy and metabolic inhibition, may overcome drug resistance, yield significant therapeutic outcomes for patients with GIST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10955424	Crizotinib at 2 μM was combined in the appropriate samples as indicated (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Crizotinib", "at", "2", "μM", "was", "combined", "in", ...
PMC11237030	As expected, unstimulated CHO-K1/AQP5 showed a visible AQP5 staining at the plasma membrane but less strong compared to cells stimulated with cpt-cAMP but also an AQP5 intracellular staining that was less visible for the cpt-cAMP stimulated cells (Fig. 5).Figure 5Effect of cpt-cAMP on the sub-cellular distribution of AQP5 in CHO-K1/AQP5 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727306	The plates were subjected to an overnight incubation at 37 °C in a 5% CO2 incubator to facilitate attachment of the Vero cells to the plate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC10965315	The result of gene expression revealed that harmaline could reduce the invasiveness of A2780 cells by downregulating MMP‐2 and MMP‐9 genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "result"...
PMC11126803	D, results of 3D collagen I-induced tube formation assay show that overexpressed LncRNA-SERB can increase cell length of tubules, while knocking down ERβ can reverse it in A498 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9985266	Gokey et al. showed that in IPF epithelial cells, the most improved lncRNA is lncRNA maternally expressed gene 3 (MEG3), which plays an important role in regulating the function of basic progenitor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8193813	Concentrations were collected and recorded at 1Hz.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Concentrations", "were", "collected", "and", "recorded", "at", "1Hz", "." ] } ]
PMC11679892	These results support the critical role of oxidative stress in inducing apoptosis in neuroblastoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "support", "the", "critical", "role", "o...
PMC11732523	To enhance clarity, Table 2 summarizes and the key aspects of the case.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "enhance", "clarity", ",", "Table", "2", "summarizes", "and...
PMC2614416	Oxidoreductase scavenger enzyme systems of catalase (CAT), superoxide-dismutase (SOD), and glutathione peroxidase (GSH-Px) are the most important enzymatic free radical defense mechanisms that protect cells from apoptosis and other damaging effects oxidative stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772449	The control small interfering RNA si-NC and si-p38γ were transfected into PLC/PRF/5 (A-C), Huh-7 (D-F) and BEL-7404 (G-I), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O"...
PMC11322866	In the present study, we focused on the role of EZH2 in the induction of senescence in MM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "present", ...
PMC11361748	RNA isolation was then performed using Qiagen RNeasy mini kit (Qiagen #74104) following the manufacturer’s protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "isolation", "was", ...
PMC11770199	To uncover the mechanisms of p14-induced cell–cell fusion leading to cell death, HCT8 cells were transfected with PCDH-GFP-p14 plasmids for 20 h and RNA-sequencing (RNA-seq) analysis was performed to examine the content of differentially expressed genes (DEGs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11024707	However, no statistically significant difference was found in the logistic regression analysis performed with demographic data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "no", "statistically", "significan...
PMC10495912	Previous studies have reported TQ therapeutic potential against oxidative damage by xenobiotic agents in various tissues (Nili-Ahmadabadi et al., 2018; Bilgiç et al., 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786767	Scale bars represent (A) pre-Ex: 1 μm; post-Ex: 5 μm; (B) whole cells: 10 μm; enlarged segment: 2.5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Small molecule inhibitors that block the interaction between MLL1 and its adaptor protein Menin have been shown to impair binding of MLL1 to a subset of its target genes and to inhibit leukemia cell proliferation and self renewal.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8427838	We incubated whole cell lysate derived from 786-0 renal carcinoma cells with the agarose resin bound with GST-TMIGD1 and analyzed the GST-TMIGD1 captured proteins via liquid chromatography–tandem mass spectrometry (LC–MS/MS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	T. Dragojević, O. Mitrović Ajtić, M. Diklić, T. Subotički, D. Đikić, E. Živković, V. Čokić, M. Vukotić Department of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, Belgrade, Serbia Background:: Hydroxyurea (HU) is a chemotherapeutic agent that reduces ribonucleotide reductase, stops DNA synthesis and repar, and therefore causes cell proliferation inhibition and apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11700247	One-tailed Mann-Whitney test or 2-tailed Student t tests were used to compare data sets when indicated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One-tailed", "Mann-Whitney", "test", "or", "2-tailed", ...
PMC3203927	Members of these families act as potent mitogens for multipotential neural progenitors and have been implicated in the regulation of several aspects of neurogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10955424	Malignant ascites untreated (n = 8), cirrhosis ascites (n = 3) and chemoresistance-inducing cirrhosis ascites (n = 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Overall, 134 patients (36.4%) died.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "134", "patients", "(", "36.4", "%", ")", "died", "." ] } ]
PMC9479186	Briefly, four groups of cell lines, BEL-7404, BEL-7404, SK-HEP-1, SK-HEP-1, were incubated separately.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ...
PMC10135767	The interaction between integrin α4β7 and MAdCAM-1 was found to effectively trigger calcium signaling in firmly adhered RPMI 8226 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "The", "interacti...
PMC11367146	Bar plot of top 10 GO terms enrichment analysis of the biological process, cellular components and molecular functions, respectively. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bar", "plot"...
PMC11777207	Upon limiting amounts of CD80, such as in the absence of proper activation, PD-L1 monomer is available for interaction with PD-1 (6, 11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4005030	PCA treatments also reduced the levels of interleukin-6 and tumor necrosis factor-α in heart and kidney.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PCA", "treatments", "also", "reduced", "the", "levels"...
PMC10847511	Large-scale, high-throughput screens databases for cancer cell lines from diverse backgrounds may have fundamental difficulties in reproducing clinical tumor sensitivities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Large-scale", ",", ...
PMC11224020	RNA extraction was performed using an RNeasy Micro RNA kit (Qiagen), according to the manufacturer’s protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "extraction", "was", ...
PMC10522430	The activation of caspase-9 further stimulates the activation of caspase-3 , which orchestrates apoptosis by cleaving and activating proteins crucial for the proteolytic degradation of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	With a median follow-up of 17 months, 65% of the patients had ongoing response, with 57% ongoing in CR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", ...
PMC10988555	A2780 cells were seeded at a density of 2 × 10 cells/well in 6-well plates and incubated for 24 h. After that time, the medium was replaced by medium mixed with complexes 2–4 at their IC50.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8097906	Additionally, the VSM extract was incubated on a further RMA cell line HA-OH1, to verify the results got by RH-30.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC8922418	The modified CD4 T cells were resistant to X4 and/or R5-tropic HIV-1 infection and exhibited a selective advantage over unmodified cells (Liu et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11791478	RLU, relative light unit.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "RLU", ",", "relative", "light", "unit", "." ] } ]
PMC11637276	In addition, integrins and stress responses have been linked to therapy resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "integrins", "and", "stress", "responses", "have", ...
PMC9429973	Key to successful therapy is effective disease control whilst maintaining a competent anti-infection response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Key", "to", "successful", "therapy", "is", "effective", "disease", ...
PMC11781181	The levels of MDA, 4-HNE and PTGS2 reduced significantly in the plasma and skin lesions of patients with SJS/TEN after 2 weeks of system corticosteroids treatment (P < 0.05) (Fig. 1L-M).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742864

Yuanyuan Liu et al. revealed that the levels of pro-apoptotic factors BAX and Caspase-3 were upregulated after DHA and EPA treatments while downregulating the anti-apoptotic factors Bcl-2 and Bcl-xl.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8996378

Some lathyrane-type diterpenoids, including compounds 52–54, were isolated from Euphorbia lagascae (Table 2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "lathyrane-type", "diterpenoids", ",", "in...

PMC11367146

Then, the refined core proteins and core compounds were uploaded to the PyRx tool for docking.

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PMC10443665

All experiments were conducted with cells in the logarithmic growth phase.

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PMC11773391

The transcriptional activity of the MGMT promoter can be reflected by luciferase expression (Figure 1B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "transcriptional", "activity", "of", "the",...

PMC10125312

Hek293 also had lower uptake than the other noncancerous cell lines studied, showing a trend in kidney cells with a lower uptake of AuNR-PEG in vitro compared with lung or liver cell lines under the same conditions.

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PMC11653533

Ordinarily; fruits, airborne roots, bark, and leaves as well as entire trees are traditionally related to diarrhea, dysentery, menorrhagia, anxious, and tonic properties; but, concurring to Ayurveda it is primarily utilized for the treatment of diabetes (Verma et al., 2015).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10747139

Inside the tumor, Ru(III) is proposed to be activated by its reduction to Ru(II) due to prevalent reductive conditions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inside", "th...

PMC4277423

In the present study, we silenced CCR5 via CRISPR associated protein 9 (Cas9) and single guided RNAs (sgRNAs).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...

PMC8633974

U1 and JLat cells contain one or more integrated copies of the viral genome in each cell.

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PMC11803918

After 1 h, tumor tissues were irradiated for 10 min using red light LED (650 nm, 100 mW/cm, 10 min).

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PMC11407042

•Incorrect wavelength of the plate reader may lead to low absorbance.

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PMC11742864

Here we present the key roles of ω-3 LCPUFAs as dietary supplementations in lung cancer, comprehensively review the recent progress on the underlying mechanisms of cancer cell regulation by ω-3 LCPUFAs, and introduce the application of ω-3 LCPUFAs in the clinical management of lung cancer and its malignant complications.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10589262

Moreover, UPR is involved in mutant protein folding, which also indicates that UPR might be involved in ERQC bypass and Golgi retention of MT-KIT.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11387401

Altogether, our small-scale ASO-mediated screen to probe the functional effects of HIV-1 protein-interacting RNAs on HIV-1 replication indicates that this HIV-1 protein–host RNA dataset is a valuable source for HIV-1 research.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8526701

The rate of apoptotic induction using 0.5 μM GSK602 was considerably lower in PUMA-KO cells than in WT GIST-882 cells (Fig. 3E).

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PMC11023271

We have previously shown that down-regulation of RIPK4 led to enhanced cell proliferation in keratinocyte- or SCC-derived cell lines .

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PMC10606998

A weak radiosensitizing effect was found only in the Gl-Tr line for the 1.2 MeV gamma irradiation and there was no radiosensitizing effect in both lines for the 200 MeV proton irradiation at the Bragg peak.

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PMC10938336

The substantial degree of connectivity associated with these hub genes underscores their prominence in the PPI network and suggests their indispensable roles in mediating interactions between various proteins.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9841531

A PI/Annexin V-FITC double staining method was used to carry out a flow cytometry-based apoptosis assay, as reported earlier.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "PI/Annexin", "V-FITC", ...

PMC11502962

The MIF/CXCR4 axis could contribute to drug resistance in tumor invasion and metastasis (41, 43).

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PMC11721277

The volume of the aliquot applied to the column is 3.00 μL. The detection of compounds was carried out in the mode of detecting positively charged ions during heated electrospray ionization (HESI).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11786704

By reducing the generation of ROS, the PC capsule effectively protects cells from oxidative stress damage, which in turn promotes cell survival and wound healing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11674441

The purity of the isolated CD8-positive and CD4-positive T cells was determined via flow cytometry and exceeded 97%.

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PMC9429973

The median OS and DFS of the entire cohort were respectively 41.9 and 37.6 months, with an OS and DFS at 5 years of 43% and 39%, respectively.

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PMC10669128

As a result, FUS expression in CHOP transgenic mice restored liposarcoma development, indicating that the FUS and CHOP domains cooperate in mutual liposarcoma restoration .

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PMC11633763

OCR values of USP22 silenced 143B cells with and without HK2 overexpression. *

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PMC11402217

This research presents the anticancer agent XD23, which modulates DKK1, thereby influencing Wnt/β-catenin signaling.

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PMC9429973

Limited data is available on the relationship between the SARS-CoV-2 vaccine and the development of aplastic anemia (AA).

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PMC10818573

Nfo was added to cut off the C3-Spacer of the 3′ end of the probe to obtain a new target fragment with both labels and eliminate the interference of the primer dimer.

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PMC11401350

mean (SD); (A,B) No vector d3 n = 4, d6 n = 4; PGK-GFP d3 n = 5, d6 n = 3; PGK-CAR d3 n = 7, d6 n = 4; EF1a-GFP d3 n = 3, d6 n = 3; EF1a-CAR d3 n = 3, d6 n = 3 n = 4; **p < 0.01; (C,D), No vector d3 n = 7, d6 n = 6; PGK-GFP d3 n = 5, d6 n = 5; PGK-CAR d3 n = 7, d6 n = 4; EF1a-GFP d3 n = 3, d6 n = 3; EF1a-CAR d3 n = 3, d6 n = 3; **p < 0.01, ***p < 0.001; multiple t-test). (

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PMC11740399

Mechanistic studies showed that 3025@ML inhibited the PI3K/AKT/mTOR signaling pathway and reduced the expression of key metabolic regulators PKM2 and FASN.

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PMC9429973

In each group patients received 60mg of elemetal iron.

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PMC10858941

However, in the case of the A-172 cell line, which exhibited higher on-chip metabolic activity than the U-251 MG line (Suppl.

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PMC11762280

Human skin samples of sun-exposed and non-exposed areas were collected and performed immunohistochemical studies for N-GSDMD, cleaved PARP, and p-MLKL.

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PMC9219615

Approximately 20,000 events (cells) were acquired per sample.

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PMC9429973

There is no gold standard intensive CIT regimen.

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PMC11796104

KEGG pathway enrichment analysis indicated that several pathways were significantly enriched, including Metabolic pathways (p = 2.17E-12), RNA transport (p = 9.92E-11), Ubiquitin mediated proteolysis (p = 3.32E-09) and Amyotrophic lateral sclerosis (p = 1.79E-08) (Fig. 3D).

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PMC11502962

Human GIST cells GIST882 with a mutation in KIT exon 13 were provided by Jonathan Fletcher (Dana-Farber Cancer Institute, Boston, MA) (19, 20).

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PMC9429973

Aims: We hypothesised that impairment of T cell receptor (TCR) signalling through off-target binding of Src kinases, including Lck, would be an additional mechanism of immune dysfunction.

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PMC11721064

Morphological analysis revealed pronounced fibroblast contamination in cultures using dKSFM and SHEM, while SKCs maintained a relatively uniform keratinocyte morphology and predominant growth in KSFM (Additional file 1: Fig. S2B).

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PMC11638255

Overall, the addition of TETA to anti-GD2 therapy significantly extended survival when compared to the respective monotherapy arms.

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PMC5673955

N = 4.

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PMC11803918

Antibodies used for immunofluorescence and flow cytometry and their origin were listed in Table S1.

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PMC11665584

This study demonstrates that PITX1 is a powerful driver of an oral keratinocyte transcriptional program that has pleiotropic effects on keratinocyte lineage and interactions with other tissue-resident cells and on overall tissue morphology.

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PMC11774112

The inhibitory effect of PHRD-DTIC was greater than that of free DTIC at almost all concentrations, probably due to the rapid uptake of nanocarriers with a size of ~150 nm and the sustained release of DTIC from PHRD-DTIC.

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PMC6627640

Importantly, repression of H3K27 methylation conferred cisplatin resistance to parental cells while induction of H3K27 methylation resulted in an increased cisplatin sensitivity.

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PMC11126803

Ethical Approval and consent to participate Ethical consent was approved by the Human Subjects Research Ethics Review Committee of the Tianjin Third Central Hospital affiliated to Nankai University.

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PMC9429973

The methods of descriptive (mean ± standard deviation, median (range), frequency (%)) and analytic statistics (Student’s t-test, chi-squared test) were used.

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PMC11650848

The ZFP57 protein and its cofactor KAP1 recruit the H3K9 methyltransferase SETDB1 and DNA methyltransferase (DNMT) enzymes to maintain histone and DNA methylation marks at ICRs .

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PMC9429973

E. Dann, T. Inbar, T. Mashiach, J. Eisa, S. Ringelstein-Harlev, N. Horowitz Rambam Health Care Campus; The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel Background: In patients (pts) with hematological malignancies, COVID-19 is considered to be associated with a high risk of severe morbidity and mortality.

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PMC7504302

Suggestive of a therapeutic role, ERβ silencing sensitized REN cells to Gefitinib treatment .

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PMC11748335

No significant motifs were found in the NE2 vs KYSE510 group.

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PMC11476666

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH, forward primer 5’-TGGTATCGTGGAAGGACTCATGAC-3’, reverse primer 5’-ATGCCAGTGAGCTTCCCGTTCAGC-3’) was used as internal reference and co-amplified with target samples using identical experimental conditions.

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PMC4369959

Ginger and its components have been shown to modulate a wide range of signaling molecules (Figure 3).

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PMC9429973

Aims: DREAMM-6 (NCT03544281) Arm A is evaluating belamaf in combination with LenDex in patients with RRMM.

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PMC11782780

Cells were cultured at 37°C with 5% CO2.

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PMC6742971

The effector to melanoma cell ratios were 30:1, 10:1, 3:1, 1:1.

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PMC11627398

ROC curves verified the diagnostic value of SLC31A1, MTF1, LIAS and LIPT1 genes in the GSE26640 cohort. (

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PMC11541409

As the landscape of GIST treatment continues to evolve, an integrated, multifaceted approach involving novel TKIs, combination therapy and metabolic inhibition, may overcome drug resistance, yield significant therapeutic outcomes for patients with GIST.

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PMC10955424

Crizotinib at 2 μM was combined in the appropriate samples as indicated (B).

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PMC11237030

As expected, unstimulated CHO-K1/AQP5 showed a visible AQP5 staining at the plasma membrane but less strong compared to cells stimulated with cpt-cAMP but also an AQP5 intracellular staining that was less visible for the cpt-cAMP stimulated cells (Fig. 5).Figure 5Effect of cpt-cAMP on the sub-cellular distribution of AQP5 in CHO-K1/AQP5 cells.

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PMC11727306

The plates were subjected to an overnight incubation at 37 °C in a 5% CO2 incubator to facilitate attachment of the Vero cells to the plate.

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PMC10965315

The result of gene expression revealed that harmaline could reduce the invasiveness of A2780 cells by downregulating MMP‐2 and MMP‐9 genes.

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PMC11126803

D, results of 3D collagen I-induced tube formation assay show that overexpressed LncRNA-SERB can increase cell length of tubules, while knocking down ERβ can reverse it in A498 cells.

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PMC9985266

Gokey et al. showed that in IPF epithelial cells, the most improved lncRNA is lncRNA maternally expressed gene 3 (MEG3), which plays an important role in regulating the function of basic progenitor cells.

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PMC8193813

Concentrations were collected and recorded at 1Hz.

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PMC11679892

These results support the critical role of oxidative stress in inducing apoptosis in neuroblastoma cells.

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PMC11732523

To enhance clarity, Table 2 summarizes and the key aspects of the case.

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PMC2614416

Oxidoreductase scavenger enzyme systems of catalase (CAT), superoxide-dismutase (SOD), and glutathione peroxidase (GSH-Px) are the most important enzymatic free radical defense mechanisms that protect cells from apoptosis and other damaging effects oxidative stress.

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PMC11772449

The control small interfering RNA si-NC and si-p38γ were transfected into PLC/PRF/5 (A-C), Huh-7 (D-F) and BEL-7404 (G-I), respectively.

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PMC11322866

In the present study, we focused on the role of EZH2 in the induction of senescence in MM cells.

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PMC11361748

RNA isolation was then performed using Qiagen RNeasy mini kit (Qiagen #74104) following the manufacturer’s protocol.

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PMC11770199

To uncover the mechanisms of p14-induced cell–cell fusion leading to cell death, HCT8 cells were transfected with PCDH-GFP-p14 plasmids for 20 h and RNA-sequencing (RNA-seq) analysis was performed to examine the content of differentially expressed genes (DEGs).

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PMC11024707

However, no statistically significant difference was found in the logistic regression analysis performed with demographic data.

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PMC10495912

Previous studies have reported TQ therapeutic potential against oxidative damage by xenobiotic agents in various tissues (Nili-Ahmadabadi et al., 2018; Bilgiç et al., 2023).

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PMC11786767

Scale bars represent (A) pre-Ex: 1 μm; post-Ex: 5 μm; (B) whole cells: 10 μm; enlarged segment: 2.5 μm.

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PMC9429973

Small molecule inhibitors that block the interaction between MLL1 and its adaptor protein Menin have been shown to impair binding of MLL1 to a subset of its target genes and to inhibit leukemia cell proliferation and self renewal.

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PMC8427838

We incubated whole cell lysate derived from 786-0 renal carcinoma cells with the agarose resin bound with GST-TMIGD1 and analyzed the GST-TMIGD1 captured proteins via liquid chromatography–tandem mass spectrometry (LC–MS/MS).

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PMC9429973

T. Dragojević, O. Mitrović Ajtić, M. Diklić, T. Subotički, D. Đikić, E. Živković, V. Čokić, M. Vukotić Department of Molecular Oncology, Institute for Medical Research, National Institute of Republic of Serbia, Belgrade, Serbia Background:: Hydroxyurea (HU) is a chemotherapeutic agent that reduces ribonucleotide reductase, stops DNA synthesis and repar, and therefore causes cell proliferation inhibition and apoptosis.

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PMC11700247

One-tailed Mann-Whitney test or 2-tailed Student t tests were used to compare data sets when indicated.

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PMC3203927

Members of these families act as potent mitogens for multipotential neural progenitors and have been implicated in the regulation of several aspects of neurogenesis.

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PMC10955424

Malignant ascites untreated (n = 8), cirrhosis ascites (n = 3) and chemoresistance-inducing cirrhosis ascites (n = 1).

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PMC9429973

Overall, 134 patients (36.4%) died.

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PMC9479186

Briefly, four groups of cell lines, BEL-7404, BEL-7404, SK-HEP-1, SK-HEP-1, were incubated separately.

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PMC10135767

The interaction between integrin α4β7 and MAdCAM-1 was found to effectively trigger calcium signaling in firmly adhered RPMI 8226 cells.

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PMC11367146

Bar plot of top 10 GO terms enrichment analysis of the biological process, cellular components and molecular functions, respectively. (

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PMC11777207

Upon limiting amounts of CD80, such as in the absence of proper activation, PD-L1 monomer is available for interaction with PD-1 (6, 11).

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PMC4005030

PCA treatments also reduced the levels of interleukin-6 and tumor necrosis factor-α in heart and kidney.

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PMC10847511

Large-scale, high-throughput screens databases for cancer cell lines from diverse backgrounds may have fundamental difficulties in reproducing clinical tumor sensitivities.

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PMC11224020

RNA extraction was performed using an RNeasy Micro RNA kit (Qiagen), according to the manufacturer’s protocol.

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PMC10522430

The activation of caspase-9 further stimulates the activation of caspase-3 , which orchestrates apoptosis by cleaving and activating proteins crucial for the proteolytic degradation of cancer cells.

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PMC9429973

With a median follow-up of 17 months, 65% of the patients had ongoing response, with 57% ongoing in CR.

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PMC10988555

A2780 cells were seeded at a density of 2 × 10 cells/well in 6-well plates and incubated for 24 h. After that time, the medium was replaced by medium mixed with complexes 2–4 at their IC50.

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PMC8097906

Additionally, the VSM extract was incubated on a further RMA cell line HA-OH1, to verify the results got by RH-30.

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PMC8922418

The modified CD4 T cells were resistant to X4 and/or R5-tropic HIV-1 infection and exhibited a selective advantage over unmodified cells (Liu et al., 2017).

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PMC11791478

RLU, relative light unit.

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PMC11637276

In addition, integrins and stress responses have been linked to therapy resistance .

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PMC9429973

Key to successful therapy is effective disease control whilst maintaining a competent anti-infection response.

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PMC11781181

The levels of MDA, 4-HNE and PTGS2 reduced significantly in the plasma and skin lesions of patients with SJS/TEN after 2 weeks of system corticosteroids treatment (P < 0.05) (Fig. 1L-M).

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