Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11532793
observed type 1 error rate for the different DTE methods calculated as the proportion of transcripts with unadjusted P-values <0.05 in null simulations (without differential expression) quantified with Gibbs sampling.
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PMC11301242
MF: molecular function; CC: cellular component; BP: biological process. (
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PMC9429973
Moreover, 3 individuals with c.-140C>G variant were diagnosed with the oncologic disorder: 2 with essential thrombocythemia and 1 with multiple myeloma.
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PMC11451940
Electronic spectra of complex 1 were measured using a Jasco V-750 UV-vis spectrophotometer (Jasco, Easton, MD, USA).
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PMC11092418
SRC/c-kit/Abl inhibitor dasatinib inhibited the growth of all four HBCCLs with IC50 of ≤ 3 µM. Interestingly, treatment with dasatinib was more effective in inhibiting the growth of HBCCLs when they were growing at slower rate (i.e., in medium containing lower serum concentration).
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PMC11594074
This evidence prompted us to investigate the induction of apoptosis via DNMT1 inhibition in CCRF-CEM leukemia cells.
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PMC6034753
Representative IncuCyte live cells images illustrating evolution of apoptotic cells (green) at 0, 60 and 90 h. Transfection control, Caspase 3/7 positive control and negative control cells were used as controls.
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PMC8633974
Third, optimal combination gRNAs must minimize any emergence of CRISPR-resistant escape mutants .
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PMC11543853
The reactions of virions of rhinovirus 14 to the genome-inducing environmental stimuli were shown to be heterogeneous – some of the virions remained in native form, while others converted to activated particles or released their genomes.
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PMC11541409
: p. 1219-1226.This reference is of importance because it reports that lower blood glucose concentration is beneficial for improving the therapy outcome.
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PMC8270637
Subsequently, the results showed that the level of NFATc1 in the nucleus of T cells was significantly increased after stimulation with TGF-β1.
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PMC11453018
DAPI (blue) was used to stain the nuclei.
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PMC11721064
D Expression levels of STAT family characteristic genes in corneal and skin cells, with boxes representing the median and interquartile ranges.
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PMC11676670
Cell viability was determined using MTT reagent (Sigma-Aldrich, St. Louis, MO, USA).
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PMC9429973
Methods: Using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER)-18, we conducted a retrospective study with patients diagnosed with FL (ICD-0-3 code 9690/3) between 2012 and 2018.
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PMC10705095
Taken together, these findings support the crucial involvement of HBQ1 in the development and progression of lung adenocarcinoma and its potential as a therapeutic target.
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PMC10094992
MCSs were generated according to a published protocol of 1% agarose in sterile water solution.
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PMC11519788
The duality underscores the context-dependent roles of SPOP in cancers.
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PMC11064533
Both alignment and feature counting were performed using the R package Rsubread (20).
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PMC9429973
These clinical features could be also critical factors that guide the diagnostic process.
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PMC9848491
In this study, we established a predictive signal based on ER stress-related lncRNAs; identified its value for prognosis, diagnosis, tumor immune infiltration, and chemotherapy response in UCEC patients; and performed internal validation.
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PMC11621493
Alternatively, it has been proposed that DIESL possesses acyl-CoA–dependent MGAT and DGAT activity (38).
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PMC11429241
Both ovarian cancer cell lines adhered to all the scaffolds no matter what kind of material they were made of.
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PMC11657695
The current density of these 10 cells was also significantly decreased compared to control cells with a 42% reduction in current density at + 60 mV (Fig. 2E, upper panel).
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PMC11741906
Extensive preclinical and large-scale clinical validation is necessary to confirm their efficacy and safety .
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PMC11285179
Each symbol represents data from a replicate.
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PMC9429973
Reasons for voxelotor prescription (n, %) included reducing the following: anemia (151, 69.9%), pain (51, 23.6%), frequency of vaso-occlusive crises (45, 20.8%), and the need for blood transfusions (17, 7.9%); multiple reasons may have been selected.
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PMC6684588
In addition to mature myofibers, this niche consists of satellite (stem) cells and their activated progeny (myoblasts), interstitial cells such as fibroadipogenic progenitors, blood vessel-associated cells (pericytes), motor neurons, and immune cells such as macrophages.
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PMC11634794
In migration and invasion experiments, cell migration ability significantly weakens after LAMP1 overexpression along with decreased penetration into matrix glue.
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PMC10452486
This treatment did not remove B2m-associated HCs on the cell surface.
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PMC3915447
These results indicate that FA based SPIO-NPs have potential uses as anticancer drug carriers and also have an enhanced anticancer effect.
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PMC11765678
ADR was dissolved in double-distilled water and stored at −80 °C.
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PMC9429973
Their epidemiological, clinical and prognostic characteristics were recorded, and the efficacy and tolerance of the therapies used were evaluated.
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PMC11790599
The scale bar is 100 μm. (
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PMC7685376
Figure 1Identification of proteins regulated by Huaier in HCC cells. (
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PMC9429973
To this end, we consider hematometric characterization of the heterozygous alpha gene triplication (ααα).
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PMC11448304
In this study, we aim to help uncover the mechanisms of radioresistance in lung adenocarcinoma by combining transcriptome, proteome, and 2-hydroxyisobutyrylome analyses to generate a comprehensive molecular profile.
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PMC11257203
Data represent the mean ± SD of three separate experiments. **
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PMC11549062
Lentiviruses for knockdown or overexpression of human PTP1B, PDGFR‐β, and Rab5 were constructed by GeneChem (Shanghai, China).
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PMC6133382
Proteins were purified using an N-terminal affinity tag derived from type 1 herpes simplex virus glycoprotein D (gD) as previously described .
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PMC10094992
One hypothesis is that cellular changes that are pro-senescent are actively anti-apoptotic and that senescent cells are resistant to apoptosis .
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PMC9429973
Standard or enhanced lymphodepletion with fludarabine and cyclophosphamide was followed by infusion of ThisCART19A at a dose range of 0.2-60x10 cells/kg.
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PMC9454852
Its activation leads to an IP3-induced Ca release (IICR) that plays a central role in the regulation of many cellular processes, including cell survival or cell death.
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PMC9429973
The correlation between autoimmune hemolysis and presence of complement on RBCs in wAIHA patients suggests a role for the complement system in the pathogenesis of wAIHA, which can be triggered by C1q binding to autoantibodies bound to RBCs.
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PMC10996034
Focal adhesions are subcellular structures that provide strong adhesion to the extracellular matrix (ECM) and serve as scaffolds for a number of signaling pathways involving integrins or mechanical forces applied to cells.
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PMC11470999
The binding of PF‐Biotin to the various purified proteins was then detected by Coomassie blue staining. (
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PMC11552389
Immunofluorescent staining revealed increased autophagic activity in drug-resistant melanoma cells, and FOXN3 was found to preferentially localize to distinct cell compartments in response to Vemurafenib resistance.
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PMC11499955
The choice of the MS-tag is of prime importance as its structure impacts both on signal improvement, by 10 – to 10 – fold depending on the type of tag, and on the possibilities of isotope incorporation, and thus on multiplexed analyse capacities.
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PMC11627060
Lane 1: M – molecular weight of marker of 1 kb ladder, Lane 2: S – sample after 24 h of treatment. (
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PMC9429973
This approach can be considered as a worthy alternative to donor.
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PMC11794847
Using lung metastasis model, we aimed to gauge the effect of activated T cells on the metastatic potential of NSCLC (Fig. 3F).
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PMC11499381
Intensity was compared by two-way repeated measures ANOVA with Fisher's LSD test, comparing fixed and live cells within and between fusion orientations.
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PMC11092418
All purchased and inhouse antibodies were solubilized in sterile phosphate buffered saline (PBS) and stored at 4 °C in the fridge for short-term use, at stock concentrations of 1 mg/mL for inhouse antibodies, and 0.5 mg/mL for purchased antibodies.
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PMC11763126
C Western blot analysis of USP5 protein levels after treatment with CBDP1.
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PMC11365427
All samples were treated using the same procedures as those employed in untargeted metabolomics analysis.
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PMC9164404
C Particle size of Abplatin following incubation in PBS for 7 days.
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PMC11711345
The servers indicated that none of the terpenes studied may be substrates or inhibitors (probability < 70%) of 8 among 13 CYP enzymes investigated.
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PMC7433824
Therefore, the reduction of a protein involved in the maintenance of telomeres may associate with the P4‐induction of senescence in gliomas.
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PMC11794588
The cytotoxic activity of all three solanaceous plant extracts was examined by using different solvents from low polarity to high polarity (hexane, chloroform, acetone, ethanol, and water).
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PMC9429973
Liquid biopsies, such as extracellular vesicles (EV) from peripheral blood, may overcome these limitations.
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PMC9780037
This protective mechanism may create an obstacle to the therapeutic action of an endocyted drug.
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PMC11194678
Consistent with the above results, mass spectrometry data analysis revealed that in U251 cells overexpressing STAU1, several downstream target genes of TFEB were downregulated, including subunits of the vacuolar ATPase (v-ATPase) (Fig. S4 D), which are essential for lysosome acidification (Wang et al., 2024).
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PMC11201245
Each recording to be evaluated is created as a seven-layer Z-stack so that no signals are lost in the three-dimensional core.
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PMC11756514
First, we cannot confirm the strict dependency of the β-GlcNAc orientation as compared to the α-GlcNAc orientation for both the langerin ECD and with langerin-expressing HEK293 cells, since we do not observe a difference in the interaction with the JE2ΔtarM and JE2ΔtarS mutants.
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PMC11348300
Interestingly, our observations consistently show that reoxygenation times are longest at the tumor center, where pressure is presumed to be highest during palpation.
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PMC11604768
However, off-the-shelf availability is extremely limited, often necessitating the in-house development of new promoters with desired characteristics (e.g., high dynamic range, defined basal activity, short length, etc.).
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PMC11661040
After incubation at 37℃ for 2 h, the absorbance of the solution at 450 nm wavelength was detected with an microplate reader (Thermo Fisher, USA).
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PMC9895440
NY-ESO-1 TCR specific T cells were plated at 0.125 mio/ml specific cells.
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PMC11707577
Collectively the results indicate that phage‐templated synthesis of organic nanoparticles represents a general strategy, exploitable in many diagnostic and therapeutic fields based on targeted imaging and light mediated cell ablation.
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PMC9031474
A possible reason is also the enhanced membrane mobility of the bis-acetals because of the less polar structure compared to polygodial (2).
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PMC11218145
After anesthetization by inhalation of isoflurane (Induction phase: 3,5% in O2, Maintenance phase: 1–2% in O2) continuously dispensed for the duration of the procedure, mice were i.p.
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PMC6889484
pROD12 is a full-length infectious molecular clone of HIV-2 (a gift from Keith Peden).
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PMC9429973
Questionnaires were administered pre-dose on cycle (C) 1 Day (D) 1, on C1D15, C2D1, C2D15, and on D1 of every odd cycle thereafter until the end of treatment.
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PMC9429973
At the date of data censoring 4 patients with MF/SS were alive in CR and relapse/GVHD free, while 1 patient was alive but in PR after the second relapse treated with pembrolizumab 39 months after alloHSCT Summary/Conclusion: Due to the rarity of the studied lymphoma subtypes our cohort was small and proper statistical analysis of data could not be done safely.
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PMC9430052
Pts had received a median of 2 (range 2-3) prior lines of therapy.
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PMC11594806
They further observed that CD73 contributes to PDAC metastasis by binding to the E3 ligase Tripartite Motif-Containing 21 (TRIM21) and competing with Snail for the binding site.
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PMC10944868
Concerning our tested compounds, it is worth noting that none meet the necessary criteria to be considered substrates of P-glycoprotein (PGP).
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PMC9611901
Looking at the composition of the substances used for vegetable tanning, it becomes clear that it is a very complex mixture of potentially reactive chemicals.
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PMC11733919
acetylacetonate (Fe(acac)3), oleic acid (OA), PMAO (MW: 30,000–50,000 g/mol), 1,2-dihydroxybenzene-3,5-disulfonic acid (Tiron), sulfo-N-hydroxysuccinimide (S-NHS), Amicon ultracentrifugal filters and mixed cellulose esters (MCE) membrane (GSWP04700) were purchased from Merck KGaA (Darmstadt, Germany).
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PMC11703992
The colors indicate the significance of the effect.
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PMC9429973
No significant differences were found in progression-free survival (PFS) (p=0.3) between the 14 patients with CR and the 48 patients who showed PR or less in the interim imaging.
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PMC7582629
Raman mapping rather than single-point spectral analysis could benefit surgeons, allowing a more complete visualization of the cancer cells.
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PMC11507371
Quantification cycles (Cq) between 5 and 35 were considered relevant for further analysis.
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PMC11013014
159–160 °C.
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PMC7887261
Interestingly, the MAF of p.I24M fs*22del in the AJ population was 5-fold higher than the general population in gnomAD.
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PMC10502403
The number of infused NE1-GMCs was 5×10 cells/mouse.
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PMC11754432
t tests (tissue) and two-way ANOVA (cells) were performed; significance denoted by *P < 0.05, **P < 0.01, ***P < 0.001.
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PMC8740518
Isoleucine is an essential amino acid (EAA) for mammals, used for biosynthesis, energy production, and as a mediator of redox balance (Lieu et al., 2020).
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PMC11596967
Given that many bacteria produce antimicrobial peptides (AMPs), these organisms are potential sources of antioxidant AMPs.
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PMC10582049
Using graph-based uniform manifold approximation and projection algorithm (UMAP) and Leiden clustering algorithm, 26 cell clusters were identified.
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PMC11267830
Whether RBM39 has prognostic value in T-ALL is currently unclear.
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PMC9429973
QLQ-AA/PNH Cognitive Functioning (CF) median score was 0 (IQR 0-25), Emotional Functioning 20 (IQR 5-35), Fatigue (FA) 20 (IQR 10-30), Illness Intrusiveness (II) 11 (IQR 4-32), other symptoms (OS) 11 (0-21), Physical Functioning (PF) 17 (0-33), Role Functioning (RF) 14 (9-32), Stigmatisation (ST) 12 (0-25) and Fear of Progression (PAF) 123 (4-29).
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PMC11348300
The ratio is utilized as a way to self-normalize the PpIX fluorescence signal, effectively removing concentration as a variable.
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PMC8567602
SS18–SSX and Smarcb1 compete in the balance between sarcomagenesis and tumor suppression, driving different phenotypes.
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PMC10975211
While promising, translating buforin-containing bioconjugates from preclinical studies to clinical applications requires rigorous evaluation.
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PMC11347429
MDGA1 (MAM Domain Containing Glycosylphosphatidylinositol Anchor 1) affects type I IFN in epithelial cells (69).
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PMC9784246
Gallocatechin and epigallocatechin gallate, two derivatives of the flavan-3-ol, significantly reduced the proliferation of L. amazonensis promastigotes while having little to no cytotoxicity on murine macrophages and human RBCs .
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PMC11541409
Since the enzyme (kinase) activity of KIT/PDGFRA involves transferring phosphate group from ATP to other tyrosine residues, TKIs and ATP compete to occupy the ATP-binding site in the catalytic center (Fig. 2B).
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PMC10728200
However, STUB1 overexpression was no longer able to reduce the expression of GPX4 after treatment of the cells with the proteasome inhibitor MG132 (Fig. 4C).
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PMC11518702
Mutations in additional genes implicated as secondary DLBCL drivers (62) were further defined, with a GC-B DLBCL lymphoma sub-type indicated in these important new mouse models.
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