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PMC6742971
All animal experiments were conducted in accordance with guidelines of the Animal Care and Use Committee of the Swiss Law and under animal protocols approved by the Veterinary Service of the Canton Vaud.
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PMC9220170
It has been shown that SELENOT interacts with keratinocyte-associated protein 2 (KSR 2) and other subunits of the OST complex, which may indicate its involvement in the regulation of N-glycosylation .
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PMC11765988
Out of the 1594 vitreous proteins, VRL had 1571, ocular sarcoidosis had 1425, and control patients had 1163.
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PMC10850553
Meanwhile, in humans, C5 may also be cleaved to generate C5a through complement cascades.
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PMC9844987
Notably, these promoters are also associated with a fuzzy +1 nucleosome positioning across cells within an individual.
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PMC11682172
Coronin 1A-IF FOC intensity-levels in the breast cancer cell lines before and after 72 h of co-culture with activated T lymphocytes.
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PMC11261875
Particularly, we focused on the relationship bwtween GIST and imatinib, a representative drug for treating GIST.
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PMC11401350
LTR: HIV long terminal repeat; EF1a: Elongation factor 1 alpha promoter, PGK: phosphoglycerate kinase 1 promoter; mCD4scFv: single chain variable fragment of a murine anti-CD4 antibody; 4-1BB: T cell costimulatory domain; CD3ζ: CD3 signaling domain; T2A: peptide permitting co-expression of two proteins; hCD34: epitope ...
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PMC9143157
Then, the cells were washed twice with PBS, resuspended in 500 μL PBS, followed by sonication for 30 s (UR-21P (TOMY Co. Ltd., Tokyo, Japan)).
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PMC10988555
Images were analyzed with the ImageJ MRO Wound Healing Tool or with the scratch assay measurement of the CytoSMART cloud portal for the Lux system.
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PMC10988808
The detailed protocols for Western blot, Co-immunoprecipitation, Nuclear Extraction are described in Additional file 1.
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PMC11593713
In MRC-5 cells, infection with HRV A caused a significant depletion in the GPx activity when compared to the control cells.
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PMC10996034
ZYX interacted with paxillin (PXN) and vinculin (VCL) (Fig. 2D).
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PMC9429973
According to MFC of bone marrow malignant PCs, the presence of CD319 is detected in 90% of patients (n=16).
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PMC8526701
The expression of genes was assessed through SYBR Premix Ex TaqTM (TaKaRa) on a StepOnePlus™ Real-Time PCR System, and the 2 method was used for calculations.
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PMC11640247
Cell selection and trace assessment for all cell imaging studies were performed in a blinded manner utilizing ImageJ software.
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PMC8143558
Experimental work that reported antimicrobial activity of crude plant extracts was not considered in this review because crude extracts contain a greater variety of phytochemical compounds, other than saponins, compared to saponin-enriched extracts.
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PMC10362265
Analysis of the radii of the hydrophobic residues at the interface is shown in (b), and distance distributions of the salt bridges (E35-R105: orange, red; K34-D122: green, blue).Fig.
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PMC11345828
Prior to examining modifications of the 5-position, we directed our attention to the 1,3,5-trimethylpyrazole substituent.
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PMC9429973
Major symptoms were pedal edema (37%), shortness of breath (22.2%), frothy urine (11.1%) and fatigue (11.1%).
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PMC10178190
The flavonoids fisetin and quercetin were active in restoring ERK phosphorylation, as well as sensitivity to platinum compounds .
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PMC11549612
The BP terms included endometrial cancer, based cell carcinoma, colorectal cancer, TGF-beta signaling pathway, and signaling pathways regulating pluripotency of the stem cell, and more (Figure 4C&D). -
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PMC9587298
Evaluation of cytoprotective effect promoted by pre- or co-incubation of Caco-2 cells with elderberry extracts [(elderberry extract (E), rich-phenolic extract (M), and non-phenolic extract (H)], from Sabugueiro (So), Sabugueira (Sa) and Bastardeira (Ba) cultivars, against 3 mM MGO.
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PMC9164404
The anticancer effect of AbPlatin was investigated in vitro and in vivo.
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PMC10858941
In normoxic conditions, prolyl hydroxylases (PH) hydroxylate proline residues of HIF-1α, resulting in its ubiquitination and its subsequent proteasomal degradation .
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PMC9429973
Peripheral blood CD34+ progenitors from the MK-ITP group and MK-Control group were differentiated into megakaryocytes in vitro.
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PMC9509578
Minko et al. demonstrated that doxorubicin conjugated with an HPMA copolymer has the potential to reverse drug resistance by inhibiting the drug detoxification system, inducing apoptosis by enhancing DNA damage and also suppressing UDP and glutathione expression .
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PMC7154001
For example, the cytotoxic activity of the M3 metabolite of fisetin, a plant polyphenol, against Lewis carcinoma (LLC) cell line was shown to be about 2-fold of fisetin itself (IC50 or 50% inhibitory concentrations of 24 vs. 59 µM).
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PMC10778532
Type 1 is characterized by ccRCC and hemangioblastomas, and is associated with disruptive mutations and gross deletions in VHL .
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PMC11533140
Most previous SAR studies focused on position 4 or 6 of the pyrimidine scaffolds of BKM-120 (Fairhurst et al., 2022).
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PMC11592008
To measure inflammasome activation in irradiated cells, we first performed Western blotting to visualize processed and/or secreted inflammasome proteins in cell lysates and cell supernatants (Figure 2).
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PMC7802142
For miRNA sequencing, RNA was isolated by Trizol (Life Technologies) extraction from ReN-NV and 293-NV.
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PMC11747467
Our study found that ERBB2, the target of RC48, is highly enriched in luminal bladder cancer.
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PMC11180402
The results indicated that MMP-2 and MMP-9 were dramatically decreased in 5637 cells after ISO treatment, while PTEN was markedly increased in 5637 cells following ISO treatment (Fig. 2A).
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PMC11194678
Scale bars: 10 μm. (
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PMC10605143
Studies carried out on HSF1-deficient cells and mice revealed its role in different developmental processes associated with growth , fertility , immune response and inflammation .
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PMC10502403
Mice were treated with total body irradiation (TBI) (2 Gy) and then infused with (dotted lines, n = 3) or without (solid lines, n = 3) NE1-GMCs.
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PMC8633974
Then we treated U1 and JLat cells with luciferase and GFP LNP at a dose of 2 ug per million cells.
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PMC11531735
Data is presented as Mean ± S.D., statistical significance was calculated using Student t test (*p < 0.05).
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PMC9503669
One successful approach to this problem has involved coupling of Nef to activation of the Src-family kinase Hck, a well-characterized Nef binding partner and host cell effector protein .
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PMC9429973
On the other hand, lenalidomide, as a proven effective agent for iNHL and MCL, have immune modulatory function.
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PMC10253973
The Pt(IV)-Ru(II) compounds are soluble in water.
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PMC8978939
We assessed fibronectin mRNA levels in the 786-0 and 786-0-derived cell lines expressing VHL-WT-Venus, VHL-P138R-Venus, and VHL-L163R-Venus by RT-qPCR.
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PMC9429973
NPM1 (28.6%) and FLT3 (40.5%) mutations were significantly more frequent in younger patients (χ p=0.017 and p=0.013 respectively), than in >60 years (10% and 17.1%, respectively).
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PMC6642070
Total and phosphorylated MDM2 (Ser166) protein levels with fluvastatin (10 μΜ) treatment in A-204 cells for 48 h. (c) Cytosolic extract of A-204 cells treated with fluvastatin (10 μΜ) for 48 h were immunoprecipitated (IP) with control IgG or anti-p53 antibody.
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PMC10813895
ELF5’s expression decreases in luminal epithelia with age, coinciding with DNA methylation changes in its promoter .
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PMC11610461
Additionally, some researchers have found that mutations in PSENEN are inextricably linked to the development of hidradenitis suppurative/acne inversa and Dowling-Degos disease (Xiao et al., 2020; Ralser et al., 2017; Pavlovsky et al., 2018).
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PMC11087766
Strikingly, in cells where both fluorescent fusions were detected, PicA-mCherry and stalled chimera-sfGFP colocalize on the nuclear periphery in 99.3% of infections (n = 149) (Fig. 3K and SI Appendix, Fig. S9).
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PMC11756937
Afterwards, the cells were resuspended in 1 mL of freezing medium per each well of a six-well plate, making sure that each vial had 1−2 × 10 cells.
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PMC9219615
A decrease in the G2/M phase was seen in HL-60 cells treated with Tpz-1, revealing an inverse relationship between Tpz-1 treated cells in the sub-G0/G1 and G2/M stages of cell division (Figure 4).
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PMC9429973
Notably, increased DUSP6 mRNA expression was linked to a poor clinical outcome, as evidenced by a shorter time to treatment (p=0.0109; Log-rank Test) and overall survival (p=0.0075; Log-rank Test).
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PMC9817179
Here, a fast relative overall fixation rate can either be caused by slow protein–protein interaction dynamics (low ) or fast absolute fixation rates (high ).
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PMC9509578
Nanomedicine approaches provide an efficient drug delivery platform to overcome the limitations of conventional chemotherapy and improve therapeutic effectiveness.
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PMC5415764
The cellular PTX accumulation in both sensitive A2780 and nonsenstive A2780/PTX cells was further evaluated.
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PMC11767725
Emerging therapies targeting lipid metabolism and the skin microbiome present exciting opportunities for SD management.
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PMC9429973
Image: Summary/Conclusion: In this study, we show that CAR-T cells has heterogeneous morphology identified in PBS.
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PMC11748335
We next assessed the H3K27me3 intensity and DNA methylation level of the three groups of long LOCKs.
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PMC9429973
In the clinic RAS/MAPK modulation combined with Aza reverses bone marrow failure in MDS.
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PMC11486946
CHO-K1, A431, and HeLa cells (RIKEN BRC through the National Bio-Resource Project of the MEXT, Japan) were grown at 37 °C in Ham’s F-12 medium (CHO-K1) or Dulbecco’s modified Eagle’s medium (A431, HeLa; DMEM, FUJIFILM Wako Pure Chemical, Japan); both media were supplemented with 10% fetal bovine serum (FBS).
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PMC9429973
Physical examination revealed extramedullary involvement in 4 patients: 2 had splenomegaly, one had hepatomegaly and one had lymphadenopathy.
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PMC9105697
This improved assay enables real-time monitoring of tumor activity even in localized, small tumors, independent of their anatomic location.
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PMC8735881
Among several GPI-anchored constructs, the first-generation antibody X5, which targets the gp120 co-receptor-binding site, was found to endow cells with relatively higher resistance when tested against divergent HIV-1 strains .
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PMC11655536
Data are presented as the mean ± SD of at least three independent experiments, and comparisons were evaluated by two-tailed Student’s t test. ***
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PMC11106977
The first strategy involves the targeting of O-GlcNAcylation modifying enzymes, OGT and OGA.
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PMC11607764
P < 0.001.
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PMC9621239
Serum HBsAg, HBsAb, HBeAg, HBeAb and HBcAb were measured using the automatic immune fluorescence analyser Abbott Type i4000 (Abbott Laboratories, USA), following the manufacturer’s instructions.
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PMC11790971
The Manders overlap coefficient (MOC) of 3PF intensity and phasor mean lifetime was the second most important feature in passage 2 (Fig. 5a).
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PMC9096373
The green was mainly mechanisms of APA.
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PMC7351993
At the focal point of the objective lens, the full width at half maximum along the long and short axes is 24 µm and 1 µm, respectively.
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PMC10747139
Complexes 46 and 47 reduced the cell viability to 50% at approximate concentrations of 10 µM against HepG2 cell lines.
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PMC9429973
In LR-MDS (n=8), ≥grade 3 AEs included thrombocytopenia (n=2), and neutropenia (n=2).
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PMC10831439
Two-way ANOVA.
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PMC4270159
1 µM PD173074 + no ligand [additional].
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PMC11354225
Statistical significance was established at the p < 0.05 level.
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PMC11617590
Mia PaCa‐2 cells were seeded at 1 × 10 cells/200 μL/well and were treated for 24, 48, and 72 h with sulforaphane (SFN) at concentrations of 0, 10, 25, 50, and 100 μM. 5‐Fluorouracil (5‐FU) was used as a positive control.
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PMC11301242
Notably, 38 of these are currently recognized as cancer-related genes (Fig. 2C).
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PMC11461025
phospho-ERK1/2 and GAPDH were simultaneously detected with rabbit anti-ERK and mouse anti-GAPDH antibodies and the membranes were stripped and re-probed with mouse anti-ERK antibody to detect total ERK.
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PMC9429973
The number of CG clones were similar, but the number of CG abnormalities were higher in t-MDS pts (p=0.025).
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PMC11206251
Flavonoids, diterpenoids, triterpenoids, alkaloids, lignans, and sesquiterpenoids were the identified classes of constituents in the PEIM.
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PMC11783017
KEGG pathway enrichment analysis showed that the affected proteins primarily participated in autophagy-related pathways, including downregulation of cancer pathways such as JAK-STAT3, mTOR, cAMP and PI3K-Akt, among others (Figs. S12A–C).
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PMC9429973
As a consequence, given the possibility that cancer will progress to the stage of chronic illness, the post management and regular hospital visit of MM patients are particularly important.
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PMC10142392
The study aimed to evaluate their ability to deliver a plasmid and doxorubicin, an anticancer drug.
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PMC11530949
This was followed by the chemically synthesized Ag-doped CuO NPs, which demonstrated moderate compatibility, and the Ephedra intermedia extract, which had slightly higher cytotoxicity.
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PMC8358006
Although Polycomb-dependent chromatin looping contributes to gene silencing have also been described, the relationship between higher-order chromatin structure and GSDs remains unclear.
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PMC11650848
Bipolar electrodes tracked eye movements and heartbeat rhythms, and head movement was recorded through a head–position indicator with coils placed on the child’s scalp.
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PMC3019555
HeLa–GFP-Ago2 cells treated with 25 µM 2ME2 or 25 nM TX overnight, lysed, and immunoprecipitated (IP) using an anti-GFP antibody.
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PMC11585254
Role of β-arrestins in agonist-stimulated internalization of CXCR5. (
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PMC6190245
Apoptosis was assessed by flow cytometry following propidium iodide staining.
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PMC11672617
When compared to carbonyl cyanide m-chlorophenylhydrazone, it can be observed that it causes a significantly greater dissipation of the mitochondrial membrane than compounds 3a, 3b, 4a, 4b, 5a, and 5b.
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PMC9587866
Virtual screening revealed two compounds (Sorbifolin and 1,7-dihydroxy-3-methylanthracene-9.10-dione), which can interact with the active residues via hydrogen bonding.
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PMC3915447
At present, survivin is validated as a cancer therapeutic target (21).
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PMC11543935
While the cell-laden hydrogel measures a volume of 1 cm, the healthy tissue phantom has a size of 60 cm.
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PMC6643347
The pathogenetic process of HIV infection also involves antigen-presenting cells, macrophages and dendritic cells [15-18] which possess virus-specific receptors and are capable of actively circulating in the blood and penetrating various lymphoid and non-lymphoid tissues.
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PMC6102174
Ethyl 3,4-dihydroxybenzoate and ethyl 2,5-dihydroxybenzoate also showed inhibition on HBsAg secretion with IC50 values of 0.14 (SI > 41.6) and 0.23 (SI > 32.3) mM; 2-C-β-d-glucopyranosyl-1,3,7-trihydroxyxanthone could suppress HBeAg secretion with an IC50 value of 0.04 mM (SI = 47.8) [35–37].
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PMC11190062
Infections are a major complication of MM and the underlying cause of many deaths (11–14).
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PMC10502403
In contrast, compared to NE1-GMCs, TCRγδ-specific agonistic mAb (clone IMMU510)-stimulated NGMCs remained at a similar frequency (Figure S4A) and showed similar cell proliferation (Figure S4D).
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PMC10852540
In addition, the long-term survival rate for ovarian cancer has decreased, and the rate of recurrence has increased12.
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PMC9918897
As heterotopic models, 4 × 10 BALB/c nude immunosuppressed mice (without thymus), each of them 4–7 weeks old, were investigated.
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PMC10547921
Carmaphycins can be divided into four distinct parts (P1–P4).
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PMC11127909
This suggested that EFHD1 could fix ANT3 in the m-state to prevent ANT3 from forming the mPTP complex.
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